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JAMA Psychiatry

Barbara Stanley, Gregory K Brown, Lisa A Brenner, Hanga C Galfalvy, Glenn W Currier, Kerry L Knox, Sadia R Chaudhury, Ashley L Bush, Kelly L Green
Importance: Suicidal behavior is a major public health problem in the United States. The suicide rate has steadily increased over the past 2 decades; middle-aged men and military veterans are at particularly high risk. There is a dearth of empirically supported brief intervention strategies to address this problem in health care settings generally and particularly in emergency departments (EDs), where many suicidal patients present for care. Objective: To determine whether the Safety Planning Intervention (SPI), administered in EDs with follow-up contact for suicidal patients, was associated with reduced suicidal behavior and improved outpatient treatment engagement in the 6 months following discharge, an established high-risk period...
July 11, 2018: JAMA Psychiatry
Olivera Story Jovanova, Ivana Nedeljkovic, Spieler Derek, Rosie M Walker, Chunyu Liu, Michelle Luciano, Jan Bressler, Jennifer Brody, Amanda J Drake, Kathryn L Evans, Rahul Gondalia, Sonja Kunze, Brigitte Kuhnel, Jari Lahti, Rozenn N Lemaitre, Riccardo E Marioni, Brenton Swenson, Jayandra Jung Himali, Hongsheng Wu, Yun Li, Allan F McRae, Tom C Russ, James Stewart, Zhiying Wang, Guosheng Zhang, Karl-Heinz Ladwig, Andre G Uitterlinden, Xiuqing Guo, Annette Peters, Katri Räikkönen, John M Starr, Melanie Waldenberger, Naomi R Wray, Eric A Whitsel, Nona Sotoodehnia, Sudha Seshadri, David J Porteous, Joyce van Meurs, Thomas H Mosley, Andrew M McIntosh, Michael M Mendelson, Daniel Levy, Lifang Hou, Johan G Eriksson, Myriam Fornage, Ian J Deary, Andrea Baccarelli, Henning Tiemeier, Najaf Amin
Importance: Depressive disorders arise from a combination of genetic and environmental risk factors. Epigenetic disruption provides a plausible mechanism through which gene-environment interactions lead to depression. Large-scale, epigenome-wide studies on depression are missing, hampering the identification of potentially modifiable biomarkers. Objective: To identify epigenetic mechanisms underlying depression in middle-aged and elderly persons, using DNA methylation in blood...
July 11, 2018: JAMA Psychiatry
Yoonho Chung, Jean Addington, Carrie E Bearden, Kristin Cadenhead, Barbara Cornblatt, Daniel H Mathalon, Thomas McGlashan, Diana Perkins, Larry J Seidman, Ming Tsuang, Elaine Walker, Scott W Woods, Sarah McEwen, Theo G M van Erp, Tyrone D Cannon
Importance: Altered neurodevelopmental trajectories are thought to reflect heterogeneity in the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these trajectories are associated with future psychosis is unclear. Objective: To investigate distinct neuroanatomical markers that can differentiate aberrant neurodevelopmental trajectories among clinically high-risk (CHR) individuals. Design, Setting, and Participants: In this prospective longitudinal multicenter study, a neuroanatomical-based age prediction model was developed using a supervised machine learning technique with T1-weighted magnetic resonance imaging scans of 953 healthy controls 3 to 21 years of age from the Pediatric Imaging, Neurocognition, and Genetics (PING) study and then applied to scans of 275 CHR individuals (including 39 who developed psychosis) and 109 healthy controls 12 to 21 years of age from the North American Prodrome Longitudinal Study 2 (NAPLS 2) for external validation and clinical application...
July 3, 2018: JAMA Psychiatry
Hamdi Eryilmaz, Kevin F Dowling, Franklin C Huntington, Anais Rodriguez-Thompson, Thomas W Soare, Lauren M Beard, Hang Lee, Jeffrey C Blossom, Randy L Gollub, Ezra Susser, Ruben C Gur, Monica E Calkins, Raquel E Gur, Theodore D Satterthwaite, Joshua L Roffman
Importance: Presently, 81 countries mandate the fortification of grain products with folic acid to lessen the risk of neural tube defects in the developing fetus. Epidemiologic data on severe mental illness suggest potentially broader effects of prenatal folate exposure on postnatal brain development, but this link remains unsubstantiated by biological evidence. Objective: To evaluate associations among fetal folic acid exposure, cortical maturation, and psychiatric risk in youths...
July 3, 2018: JAMA Psychiatry
Tomáš Paus
No abstract text is available yet for this article.
July 3, 2018: JAMA Psychiatry
Charles B Nemeroff
No abstract text is available yet for this article.
June 27, 2018: JAMA Psychiatry
Jerome A Yesavage, J Kaci Fairchild, Zhibao Mi, Kousick Biswas, Anne Davis-Karim, Ciaran S Phibbs, Steven D Forman, Michael Thase, Leanne M Williams, Amit Etkin, Ruth O'Hara, Gerald Georgette, Tamara Beale, Grant D Huang, Art Noda, Mark S George
Importance: Treatment-resistant major depression (TRMD) in veterans is a major clinical challenge given the high risk for suicidality in these patients. Repetitive transcranial magnetic stimulation (rTMS) offers the potential for a novel treatment modality for these veterans. Objective: To determine the efficacy of rTMS in the treatment of TRMD in veterans. Design, Setting, and Participants: A double-blind, sham-controlled randomized clinical trial was conducted from September 1, 2012, to December 31, 2016, in 9 Veterans Affairs medical centers...
June 27, 2018: JAMA Psychiatry
Thibault Deschamps
No abstract text is available yet for this article.
June 27, 2018: JAMA Psychiatry
Dost Öngür
No abstract text is available yet for this article.
June 27, 2018: JAMA Psychiatry
Benjamin L Willis, David Leonard, Carolyn E Barlow, Scott B Martin, Laura F DeFina, Madhukar H Trivedi
Importance: Cardiorespiratory fitness (hereinafter referred to as fitness) as estimated by exercise testing is a modifiable risk factor independently associated with chronic diseases, cardiovascular disease (CVD) events, and mortality, but the association of fitness at midlife with incidence of later-life depression and the risk of CVD mortality after a depression diagnosis is unknown. Objective: To determine whether fitness measured in midlife would be inversely associated with later-life CVD mortality with antecedent depression...
June 27, 2018: JAMA Psychiatry
Katharina Dohm, Dario Zaremba, Udo Dannlowski
No abstract text is available yet for this article.
June 27, 2018: JAMA Psychiatry
Lucía Colodro-Conde, Baptiste Couvy-Duchesne, John B Whitfield, Fabian Streit, Scott Gordon, Kathryn E Kemper, Loic Yengo, Zhili Zheng, Maciej Trzaskowski, Eveline L de Zeeuw, Michel G Nivard, Marjolijn Das, Rachel E Neale, Stuart MacGregor, Catherine M Olsen, David C Whiteman, Dorret I Boomsma, Jian Yang, Marcella Rietschel, John J McGrath, Sarah E Medland, Nicholas G Martin
Importance: Urban life has been proposed as an environmental risk factor accounting for the increased prevalence of schizophrenia in urban areas. An alternative hypothesis is that individuals with increased genetic risk tend to live in urban/dense areas. Objective: To assess whether adults with higher genetic risk for schizophrenia have an increased probability to live in more populated areas than those with lower risk. Design, Setting, and Participants: Four large, cross-sectional samples of genotyped individuals of European ancestry older than 18 years with known addresses in Australia, the United Kingdom, and the Netherlands were included in the analysis...
June 23, 2018: JAMA Psychiatry
Hannah E Jongsma, Peter B Jones
No abstract text is available yet for this article.
June 23, 2018: JAMA Psychiatry
Mark Olfson, Stephen Crystal, Melanie Wall, Shuai Wang, Shang-Min Liu, Carlos Blanco
Importance: A recent increase in patients presenting with nonfatal opioid overdoses has focused clinical attention on characterizing their risks of premature mortality. Objective: To describe all-cause mortality rates, selected cause-specific mortality rates, and standardized mortality rate ratios (SMRs) of adults during their first year after nonfatal opioid overdose. Design, Setting, and Participants: This US national longitudinal study assesses a cohort of patients aged 18 to 64 years who were Medicaid beneficiaries and experienced nonfatal opioid overdoses...
June 20, 2018: JAMA Psychiatry
Paul Oliver Wilkinson
No abstract text is available yet for this article.
June 20, 2018: JAMA Psychiatry
Elizabeth McCauley, Michele S Berk, Joan R Asarnow, Molly Adrian, Judith Cohen, Kathyrn Korslund, Claudia Avina, Jennifer Hughes, Melanie Harned, Robert Gallop, Marsha M Linehan
Importance: Suicide is a leading cause of death among 10- to 24-year-old individuals in the United States; evidence on effective treatment for adolescents who engage in suicidal and self-harm behaviors is limited. Objective: To evaluate the efficacy of dialectical behavior therapy (DBT) compared with individual and group supportive therapy (IGST) for reducing suicide attempts, nonsuicidal self-injury, and overall self-harm among high-risk youths. Design, Setting, and Participants: This randomized clinical trial was conducted from January 1, 2012, through August 31, 2014, at 4 academic medical centers...
June 20, 2018: JAMA Psychiatry
Nicoline Hemager, Kerstin J Plessen, Anne Thorup, Camilla Christiani, Ditte Ellersgaard, Katrine Søborg Spang, Birgitte Klee Burton, Maja Gregersen, Anne Søndergaard, Aja Neergaard Greve, Ditte Lou Gantriis, Gry Poulsen, Larry J Seidman, Ole Mors, Merete Nordentoft, Jens Richardt Møllegaard Jepsen
Importance: Children at familial high risk of schizophrenia spectrum disorders (FHR-SZ) or bipolar disorder (FHR-BP) exhibit neurocognitive impairments. Large studies of neurocognition in young children at familial high risk at the same age are important to differentiate the pathophysiology and developmental trajectory of these 2 groups. Objective: To characterize neurocognitive functions in 7-year-old children with FHR-SZ or FHR-BP and a control population. Design, Setting, and Participants: This multisite population-based cohort study collected data from January 1, 2013, to January 31, 2016, in the first wave of the Danish High Risk and Resilience Study VIA 7 at 2 university hospital research sites in Copenhagen and Aarhus using Danish registries...
June 20, 2018: JAMA Psychiatry
Saul Shiffman, Brenda F Kurland, Sarah M Scholl, Jason M Mao
Importance: The US Food and Drug Administration is considering limiting cigarettes to very low nicotine levels. Cigarette consumption of nondaily intermittent smokers (ITS), who compose one-third of US adult smokers, could feasibly increase or could be unaffected if their smoking is not motivated by nicotine seeking. Objective: To compare cigarette consumption in ITS receiving very low-nicotine-content cigarettes (VLNCCs) or identical normal-nicotine-content cigarettes (NNCCs)...
June 14, 2018: JAMA Psychiatry
Marc De Hert, Johan Detraux
No abstract text is available yet for this article.
June 13, 2018: JAMA Psychiatry
Dheeraj Rai, Iryna Culpin, Hein Heuvelman, Cecilia M K Magnusson, Peter Carpenter, Hannah J Jones, Alan M Emond, Stanley Zammit, Jean Golding, Rebecca M Pearson
Importance: Population-based studies following trajectories of depression in autism spectrum disorders (ASD) from childhood into early adulthood are rare. The role of genetic confounding and of potential environmental intermediaries, such as bullying, in any associations is unclear. Objectives: To compare trajectories of depressive symptoms from ages 10 to 18 years for children with or without ASD and autistic traits, to assess associations between ASD and autistic traits and an International Statistical Classification of Diseases, 10th Revision (ICD-10) depression diagnosis at age 18 years, and to explore the importance of genetic confounding and bullying...
June 13, 2018: JAMA Psychiatry
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