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JAMA Psychiatry

Magdalena Janecka, Arad Kodesh, Stephen Z Levine, Shari I Lusskin, Alexander Viktorin, Rayees Rahman, Joseph D Buxbaum, Avner Schlessinger, Sven Sandin, Abraham Reichenberg
Importance: Prenatal exposure to certain medications has been hypothesized to influence the risk of autism spectrum disorders (ASD). However, the underlying effects on the neurotransmitter systems have not been comprehensively assessed. Objective: To investigate the association of early-life interference with different neurotransmitter systems by prenatal medication exposure on the risk of ASD in offspring. Design, Setting, and Participants: This case-control study included children born from January 1, 1997, through December 31, 2007, and followed up for ASD until January 26, 2015, within a single Israeli health maintenance organization...
October 31, 2018: JAMA Psychiatry
Richard G Frank, Rebecca L Haffajee
No abstract text is available yet for this article.
October 31, 2018: JAMA Psychiatry
Elinore F McCance-Katz, Brett P Giroir
No abstract text is available yet for this article.
October 31, 2018: JAMA Psychiatry
Xinyu Zhou, Yuqing Zhang, Toshiaki A Furukawa, Pim Cuijpers, Juncai Pu, John R Weisz, Lining Yang, Sarah E Hetrick, Cinzia Del Giovane, David Cohen, Anthony C James, Shuai Yuan, Craig Whittington, Xiaofeng Jiang, Teng Teng, Andrea Cipriani, Peng Xie
Importance: Anxiety disorders are common in children and adolescents, and uncertainty remains regarding the optimal strategy of psychotherapies in this population. Objective: To compare and rank the different types of psychotherapies and the different ways of delivering psychological treatments for anxiety disorders in children and adolescents. Data Sources: PubMed, Cochrane Central Register of Controlled Trials, EMBASE, PsycINFO, Web of Science, CINAHL (Cumulative Index to Nursing and Allied Health Literature), ProQuest Dissertations, LILACS (Literatura Latino Americana em Ciências da Saúde), international trial registers, and US Food and Drug Administration reports were searched from inception to November 30, 2017...
October 31, 2018: JAMA Psychiatry
Diana Schendel, Jakob Christensen, Dheeraj Rai
No abstract text is available yet for this article.
October 31, 2018: JAMA Psychiatry
Nicole R Karcher, Deanna M Barch, Catherine H Demers, David A A Baranger, Andrew C Heath, Michael T Lynskey, Arpana Agrawal
Importance: Previous research indicates that cannabis use is associated with psychotic-like experiences (PLEs). However, it is unclear whether this association results from predispositional (ie, shared genetic) factors or individual-specific factors (eg, causal processes, such as cannabis use leading to PLEs). Objectives: To estimate genetic and environmental correlations between cannabis use and PLEs, and to examine PLEs in twin and nontwin sibling pairs discordant for exposure to cannabis use to disentangle predispositional from individual-specific effects...
October 17, 2018: JAMA Psychiatry
Ana Gómez-Carrillo, Timothé Langlois-Thérien, Laurence J Kirmayer
No abstract text is available yet for this article.
October 17, 2018: JAMA Psychiatry
Jordan W Smoller, Murray B Stein
No abstract text is available yet for this article.
October 17, 2018: JAMA Psychiatry
Paolo Fusar-Poli, Ziad Hijazi, Daniel Stahl, Ewout W Steyerberg
Importance: Prognosis is a venerable component of medical knowledge introduced by Hippocrates (460-377 BC). This educational review presents a contemporary evidence-based approach for how to incorporate clinical risk prediction models in modern psychiatry. The article is organized around key methodological themes most relevant for the science of prognosis in psychiatry. Within each theme, the article highlights key challenges and makes pragmatic recommendations to improve scientific understanding of prognosis in psychiatry...
October 17, 2018: JAMA Psychiatry
Maria Ironside, Michael Browning, Tahereh L Ansari, Christopher J Harvey, Mama N Sekyi-Djan, Sonia J Bishop, Catherine J Harmer, Jacinta O'Shea
Importance: Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are unclear, and there is a lack of neuroimaging evidence, particularly among individuals with affective dysfunction. Furthermore, there is no direct causal evidence among humans that the prefrontal-amygdala circuit functions as described in animal models (ie, that increasing activity in prefrontal cortical control regions inhibits amygdala response to threat)...
October 17, 2018: JAMA Psychiatry
Paolo Fusar-Poli, Cathy Davies, Ilaria Bonoldi
No abstract text is available yet for this article.
October 17, 2018: JAMA Psychiatry
Frances Rice, Lucy Riglin, Ajay K Thapar, Jon Heron, Richard Anney, Michael C O'Donovan, Anita Thapar
Importance: Depression often first manifests in adolescence. Thereafter, individual trajectories vary substantially, but it is not known what shapes depression trajectories in youth. Adult studies suggest that genetic risk for schizophrenia, a psychiatric disorder with a neurodevelopmental component, may contribute to an earlier onset of depression. Objective: To test the hypothesis that there are distinct trajectories of depressive symptoms and that genetic liability for neurodevelopmental psychiatric disorders (eg, schizophrenia, attention deficit/hyperactivity disorder [ADHD]), as well as for major depressive disorder (MDD), contribute to early-onset depression...
October 14, 2018: JAMA Psychiatry
James B Kirkbride, Katherine M Keyes, Ezra Susser
No abstract text is available yet for this article.
October 10, 2018: JAMA Psychiatry
Rachel J Rosengard, Ashok Malla, Sally Mustafa, Srividya N Iyer, Ridha Joober, Michael Bodnar, Martin Lepage, Jai L Shah
Importance: The clinical high-risk state in psychosis is most often characterized by subthreshold psychotic symptoms (STPS) and represents a target for psychosis prevention. However, evidence suggests that between 30% and 50% of patients with a first episode of psychosis (FEP) report no prior history of STPS, indicating that not all patients with FEP experience a previous clinical high-risk phase. As with other early characteristics of illness onset, this diversity in the early course of symptoms may offer prognostic value for subsequent clinical trajectories...
October 8, 2018: JAMA Psychiatry
Tara A Niendam, Kimberly L Ray, Ana-Maria Iosif, Tyler A Lesh, Stefania R Ashby, Pooja K Patel, Jason Smucny, Emilio Ferrer, Marjorie Solomon, J Daniel Ragland, Cameron S Carter
Importance: The extent of cognitive deterioration after schizophrenia (SZ) onset is poorly understood because prior longitudinal studies used small samples of older individuals with established illness. Objective: To examine the association of age at onset and subsequent longitudinal course of prefrontal activity during the first 2 years of illness in youths with SZ and healthy control participants (HCs). Design, Setting, and Participants: This naturalistic, longitudinal, functional magnetic resonance imaging (fMRI) study included patients with recent-onset SZ and HCs aged 12 to 25 years enrolled in an ongoing study of cognition in recent-onset psychosis in the Sacramento, California, area from October 13, 2004, through June 25, 2013...
October 3, 2018: JAMA Psychiatry
Ioana-Alina Cristea, John P A Ioannidis
No abstract text is available yet for this article.
October 3, 2018: JAMA Psychiatry
Myrna M Weissman
No abstract text is available yet for this article.
October 3, 2018: JAMA Psychiatry
Aristotle N Voineskos
No abstract text is available yet for this article.
September 26, 2018: JAMA Psychiatry
Colin A Espie, Richard Emsley, Simon D Kyle, Christopher Gordon, Christopher L Drake, A Niroshan Siriwardena, John Cape, Jason C Ong, Bryony Sheaves, Russell Foster, Daniel Freeman, Joan Costa-Font, Antonia Marsden, Annemarie I Luik
Importance: Digital cognitive behavioral therapy (dCBT) is a scalable and effective intervention for treating insomnia. Most people with insomnia, however, seek help because of the daytime consequences of poor sleep, which adversely affects quality of life. Objectives: To investigate the effect of dCBT for insomnia on functional health, psychological well-being, and sleep-related quality of life and to determine whether a reduction in insomnia symptoms was a mediating factor...
September 25, 2018: JAMA Psychiatry
Gregory P Strauss, Alicia Nuñez, Anthony O Ahmed, Kimberly A Barchard, Eric Granholm, Brian Kirkpatrick, James M Gold, Daniel N Allen
Importance: Negative symptoms are associated with a range of poor clinical outcomes, and currently available treatments generally do not produce a clinically meaningful response. Limited treatment progress may be owing in part to poor clarity regarding latent structure. Prior studies have inferred latent structure using exploratory factor analysis, which has led to the conclusion that there are 2 dimensions reflecting motivation and pleasure (MAP) and diminished expressivity (EXP) factors...
September 12, 2018: JAMA Psychiatry
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