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JAMA Psychiatry

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https://www.readbyqxmd.com/read/29710317/association-of-substance-use-disorders-with-conversion-from-schizotypal-disorder-to-schizophrenia
#1
Carsten Hjorthøj, Nikolai Albert, Merete Nordentoft
Importance: Understanding the role of substance use disorders in conversion from schizotypal disorder to schizophrenia may provide physicians and psychiatrists with important tools for prevention or early detection of schizophrenia. Objective: To investigate whether substance use disorders, in particular cannabis use disorder, are associated with conversion to schizophrenia in individuals with schizotypal disorder. Design, Setting, and Participants: This prospective cohort study included a population-based sample of all individuals born in Denmark from January 1, 1981, through August 10, 2014, with an incident diagnosis of schizotypal disorder and without a previous diagnosis of schizophrenia...
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710138/opioid-use-disorder-after-self-medicating-pain-from-traumatic-brain-injury
#2
Thomas R Kosten, David P Graham, David A Nielsen
No abstract text is available yet for this article.
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710123/making-the-opioid-public-health-emergency-effective
#3
Rebecca L Haffajee, Richard G Frank
No abstract text is available yet for this article.
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710118/disorganized-gyrification-network-properties-during-the-transition-to-psychosis
#4
Tushar Das, Stefan Borgwardt, Daniel J Hauke, Fabienne Harrisberger, Undine E Lang, Anita Riecher-Rössler, Lena Palaniyappan, André Schmidt
Importance: There is urgent need to improve the limited prognostic accuracy of clinical instruments to predict psychosis onset in individuals at clinical high risk (CHR) for psychosis. As yet, no reliable biological marker has been established to delineate CHR individuals who will develop psychosis from those who will not. Objectives: To investigate abnormalities in a graph-based gyrification connectome in the early stages of psychosis and to test the accuracy of this systems-based approach to predict a transition to psychosis among CHR individuals...
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710079/neurobiology-of-opioid-use-disorder-and-comorbid-traumatic-brain-injury
#5
Thomas R Kosten, David P Graham, David A Nielsen
Importance: Treating patients with opioid use disorder (OUD) and traumatic brain injury illustrates 6 neurobiological principles about the actions of 2 contrasting opioid analgesics, morphine and fentanyl, as well as pharmacotherapies for OUD, methadone, naltrexone, and buprenorphine. Observations: This literature review focused on a patient with traumatic brain injury who developed OUD from chronic morphine analgesia. His treatment is described in a neurobiological framework of 6 opioid action principles...
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710270/associations-of-time-related-deployment-variables-with-risk-of-suicide-attempt-among-soldiers-results-from-the-army-study-to-assess-risk-and-resilience-in-servicemembers-army-starrs
#6
Robert J Ursano, Ronald C Kessler, James A Naifeh, Holly Herberman Mash, Carol S Fullerton, Pablo A Aliaga, Gary H Wynn, Tsz Hin H Ng, Hieu M Dinh, Nancy A Sampson, Tzu-Cheg Kao, Paul D Bliese, Murray B Stein
Importance: There has been limited systematic examination of whether risk of suicide attempt (SA) among US Army soldiers is associated with time-related deployment variables, such as time in service before first deployment, duration of first deployment, and dwell time (DT) (ie, length of time between deployments). Objective: To examine the associations of time-related deployment variables with subsequent SA among soldiers who had deployed twice. Design, Setting, and Participants: Using administrative data from January 1, 2004, through December 31, 2009, this longitudinal, retrospective cohort study identified person-month records of active-duty Regular Army enlisted soldiers who had served continuously in the US Army for at least 2 years and deployed exactly twice...
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710135/association-between-muscular-strength-and-cognition-in-people-with-major-depression-or-bipolar-disorder-and-healthy-controls
#7
Joseph Firth, Josh A Firth, Brendon Stubbs, Davy Vancampfort, Felipe B Schuch, Mats Hallgren, Nicola Veronese, Alison R Yung, Jerome Sarris
Importance: Objective physical fitness measures, such as handgrip strength, are associated with physical, mental, and cognitive outcomes in the general population. Although people with mental illness experience reduced physical fitness and cognitive impairment, the association between muscular strength and cognition has not been examined to date. Objective: To determine associations between maximal handgrip strength and cognitive performance in people with major depression or bipolar disorder and in healthy controls...
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710114/physical-inactivity-and-mental-health-in-late-adolescence
#8
Mark R Beauchamp, Eli Puterman, David R Lubans
No abstract text is available yet for this article.
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710074/association-of-cannabis-with-cognitive-functioning-in-adolescents-and-young-adults-a-systematic-review-and-meta-analysis
#9
J Cobb Scott, Samantha T Slomiak, Jason D Jones, Adon F G Rosen, Tyler M Moore, Ruben C Gur
Importance: Substantial shifts in perception and policy regarding cannabis have recently occurred, with use of cannabis increasing while its perceived harm decreases. One possible risk of increased cannabis use is poorer cognitive functioning, especially in youth. Objective: To provide the first quantitative synthesis of the literature examining cannabis and cognitive functioning in adolescents and young adults (with a mean age of 26 years and younger). Data Sources: PubMed, PsycInfo, Academic Search Premier, Scopus, and bibliographies of relevant reviews were searched for peer-reviewed, English-language studies from the date the databases began through May 2017...
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29710086/physician-prescribing-of-opioids-to-patients-at-increased-risk-of-overdose-from-benzodiazepine-use-in-the-united-states
#10
Joseph A Ladapo, Marc R Larochelle, Alexander Chen, Melissa M Villalon, Stefanie Vassar, David Y C Huang, John N Mafi
Importance: Recent increases in US opioid-related deaths underscore the need to understand drivers of fatal overdose. The initial prescription of opioids represents a critical juncture because it increases the risk of future opioid use disorder and is preventable. Objective: To examine new opioid prescribing patterns in US patients at increased risk of overdose from benzodiazepine use. Design, Setting, and Participants: This study used publicly available data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey from January 1, 2005, through December 31, 2015, to identify adults 20 years or older receiving new opioid prescriptions and concurrently using a benzodiazepine...
April 12, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29641834/pretreatment-rostral-anterior-cingulate-cortex-theta-activity-in-relation-to-symptom-improvement-in-depression-a-randomized-clinical-trial
#11
Diego A Pizzagalli, Christian A Webb, Daniel G Dillon, Craig E Tenke, Jürgen Kayser, Franziska Goer, Maurizio Fava, Patrick McGrath, Myrna Weissman, Ramin Parsey, Phil Adams, Joseph Trombello, Crystal Cooper, Patricia Deldin, Maria A Oquendo, Melvin G McInnis, Thomas Carmody, Gerard Bruder, Madhukar H Trivedi
Importance: Major depressive disorder (MDD) remains challenging to treat. Although several clinical and demographic variables have been found to predict poor antidepressant response, these markers have not been robustly replicated to warrant implementation in clinical care. Increased pretreatment rostral anterior cingulate cortex (rACC) theta activity has been linked to better antidepressant outcomes. However, no prior study has evaluated whether this marker has incremental predictive validity over clinical and demographic measures...
April 11, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29641818/improving-disclosure-of-financial-conflicts-of-interest-for-research-on-psychosocial-interventions
#12
Ioana-Alina Cristea, John P A Ioannidis
No abstract text is available yet for this article.
April 11, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29641816/longitudinal-associations-among-bullying-by-peers-disordered-eating-behavior-and-symptoms-of-depression-during-adolescence
#13
Kirsty S Lee, Tracy Vaillancourt
Importance: Bullying by peers has been associated with disordered eating behavior and symptoms of depression among adolescents as both an antecedent and an outcome. Identification of the temporal pattern of associations among bullying by peers, disordered eating behavior, and depression in adolescence is needed for the optimal targeting of intervention and prevention. Objective: To assess the concurrent and longitudinal associations among bullying by peers, disordered eating behavior, and symptoms of depression using a cascade model that controlled for within-time and across-time (ie, stability paths) associations while examining cross-lag effects...
April 11, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29625429/a-latent-variable-approach-to-differentiating-neural-mechanisms-of-irritability-and-anxiety-in-youth
#14
Katharina Kircanski, Lauren K White, Wan-Ling Tseng, Jillian Lee Wiggins, Heather R Frank, Stefanie Sequeira, Susan Zhang, Rany Abend, Kenneth E Towbin, Argyris Stringaris, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman
Importance: Comorbidity is ubiquitous in psychiatry, but it is unclear how to differentiate neural mechanisms of co-occurring symptoms. Pediatric irritability and anxiety symptoms are prevalent and frequently co-occur. Threat orienting is pertinent to both phenotypes and is an ideal context in which to examine their unique and common neural mechanisms. Objectives: To decompose the unique and shared variances of pediatric irritability and anxiety symptoms and to determine neural correlates of these differentiated phenotypes during threat orienting...
April 6, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29617531/consanguineous-marriage-and-the-psychopathology-of-progeny-a-population-wide-data-linkage-study
#15
Aideen Maguire, Foteini Tseliou, Dermot O'Reilly
Importance: Approximately 1 in 10 children worldwide are born to consanguineous parents. The literature on consanguinity and mental health of progeny is scarce despite the fact that many of the factors associated with consanguineous unions are also associated with mental health. Objective: To investigate if children of consanguineous parents are at increased risk of common mood disorders or psychoses. Design, Setting, and Participants: This investigation was a retrospective population-wide cohort study of all individuals born in Northern Ireland between January 1, 1971, and December 31, 1986, derived from the Child Health System data set and linked to nationwide administrative data sources on prescription medication and death records...
April 4, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29617519/consanguineous-marriage-and-the-psychopathology-of-the-progeny-of-first-cousin-couples
#16
Alison Shaw
No abstract text is available yet for this article.
April 4, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29617517/association-of-an-early-intervention-service-for-psychosis-with-suicide-rate-among-patients-with-first-episode-schizophrenia-spectrum-disorders
#17
Sherry Kit Wa Chan, Stephanie Wing Yan Chan, Herbert H Pang, Kang K Yan, Christy Lai Ming Hui, Wing Chung Chang, Edwin Ho Ming Lee, Eric Yu Hai Chen
Importance: Patients with schizophrenia have a substantially higher suicide rate than the general public. Early intervention (EI) services improve short-term outcomes. However, little is known about the association of EI with suicide reduction in the long term. Objective: To examine the association of a 2-year EI service with suicide reduction in patients with first-episode schizophrenia-spectrum (FES) disorders during 12 years and the risk factors for early and late suicide...
April 4, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29617516/safety-of-estradiol-treatment-in-perimenopausal-asymptomatic-women-reply
#18
David R Rubinow, Jennifer L Gordon, Susan S Girdler
No abstract text is available yet for this article.
April 4, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29617515/development-of-white-matter-circuitry-in-infants-with-fragile-x-syndrome
#19
Meghan R Swanson, Jason J Wolff, Mark D Shen, Martin Styner, Annette Estes, Guido Gerig, Robert C McKinstry, Kelly N Botteron, Joseph Piven, Heather C Hazlett
Importance: Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder and the most common inherited cause of intellectual disability in males. However, there are no published data on brain development in children with FXS during infancy. Objective: To characterize the development of white matter at ages 6, 12, and 24 months in infants with FXS compared with that of typically developing controls. Design, Setting, and Participants: Longitudinal behavioral and brain imaging data were collected at 1 or more time points from 27 infants with FXS and 73 typically developing controls between August 1, 2008, and June 14, 2016, at 2 academic medical centers...
April 4, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29617514/early-intervention-service-for-young-people-with-psychosis-saving-young-lives
#20
Nikolai Albert, Trine Madsen, Merete Nordentoft
No abstract text is available yet for this article.
April 4, 2018: JAMA Psychiatry
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