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JAMA Psychiatry

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https://www.readbyqxmd.com/read/29141084/association-of-obsessive-compulsive-disorder-with-objective-indicators-of-educational-attainment-a-nationwide-register-based-sibling-control-study
#1
Ana Pérez-Vigil, Lorena Fernández de la Cruz, Gustaf Brander, Kayoko Isomura, Andreas Jangmo, Inna Feldman, Eva Hesselmark, Eva Serlachius, Luisa Lázaro, Christian Rück, Ralf Kuja-Halkola, Brian M D'Onofrio, Henrik Larsson, David Mataix-Cols
Importance: To our knowledge, the association of obsessive-compulsive disorder (OCD) and academic performance has not been objectively quantified. Objective: To investigate the association of OCD with objectively measured educational outcomes in a nationwide cohort, adjusting for covariates and unmeasured factors shared between siblings. Design, Setting, And Participants: This population-based birth cohort study included 2 115 554 individuals who were born in Sweden between January 1, 1976, and December 31, 1998, and followed up through December 31, 2013...
November 15, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29141077/pediatric-use-of-antipsychotic-medications-before-and-after-medicaid-peer-review-implementation
#2
Julie M Zito, Mehmet Burcu, Stephen McKean, Rob Warnock, Jeffrey Kelman
No abstract text is available yet for this article.
November 15, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29121268/association-of-polygenic-score-for-schizophrenia-and-hla-antigen-and-inflammation-genes-with-response-to-lithium-in-bipolar-affective-disorder-a-genome-wide-association-study
#3
Azmeraw T Amare, Klaus Oliver Schubert, Liping Hou, Scott R Clark, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Urban Ösby, Andrea Pfennig, James B Potash, Andreas Reif, Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie Witt, Adam Wright, Peter P Zandi, Philip B Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J McMahon, Thomas G Schulze, Bernhard T Baune
Importance: Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ). Objectives: To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association...
November 9, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29117282/association-of-genetic-risk-for-schizophrenia-and-bipolar-disorder-with-infant-neuromotor-development
#4
Fadila Serdarevic, Philip R Jansen, Akhgar Ghassabian, Tonya White, Vincent W V Jaddoe, Danielle Posthuma, Henning Tiemeier
No abstract text is available yet for this article.
November 8, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29117275/effectiveness-of-online-collaborative-care-for-treating-mood-and-anxiety-disorders-in-primary-care-a-randomized-clinical-trial
#5
Bruce L Rollman, Bea Herbeck Belnap, Kaleab Z Abebe, Michael B Spring, Armando J Rotondi, Scott D Rothenberger, Jordan F Karp
Importance: Collaborative care for depression and anxiety is superior to usual care from primary care physicians for these conditions; however, challenges limit its provision in routine practice and at scale. Advances in technology may overcome these barriers but have yet to be tested. Objective: To examine the effectiveness of combining an internet support group (ISG) with an online computerized cognitive behavioral therapy (CCBT) provided via a collaborative care program for treating depression and anxiety vs CCBT alone and whether providing CCBT in this manner is more effective than usual care...
November 8, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29094161/inflammatory-biomarkers-and-risk-of-schizophrenia-a-2-sample-mendelian-randomization-study
#6
Fernando Pires Hartwig, Maria Carolina Borges, Bernardo Lessa Horta, Jack Bowden, George Davey Smith
Importance: Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventional observational studies are prone to bias, such as reverse causation and residual confounding, thus limiting our understanding of the effect (if any) of inflammatory biomarkers on schizophrenia risk. Objective: To evaluate whether inflammatory biomarkers have an effect on the risk of developing schizophrenia...
November 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29094160/bigger-data-harder-questions-opportunities-throughout-mental-health-care
#7
Adam M Chekroud
No abstract text is available yet for this article.
November 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29094155/inference-in-psychiatry-via-2-sample-mendelian-randomization-from-association-to-causal-pathway
#8
Enda M Byrne, Jian Yang, Naomi R Wray
No abstract text is available yet for this article.
November 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29094142/evidence-based-pragmatic-psychiatry-a-call-to-action
#9
Martin P Paulus
No abstract text is available yet for this article.
November 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29071355/extent-of-dorsolateral-prefrontal-cortex-plasticity-and-its-association-with-working-memory-in-patients-with-alzheimer-disease
#10
Sanjeev Kumar, Reza Zomorrodi, Zaid Ghazala, Michelle S Goodman, Daniel M Blumberger, Amay Cheam, Corinne Fischer, Zafiris J Daskalakis, Benoit H Mulsant, Bruce G Pollock, Tarek K Rajji
Importance: The extent of dorsolateral prefrontal cortex (DLPFC) plasticity in Alzheimer disease (AD) and its association with working memory are not known. Objectives: To determine whether participants with AD had impaired DLPFC plasticity compared with healthy control participants, to compare working memory between participants with AD and controls, and to determine whether DLPFC plasticity was associated with working memory. Design, Setting, and Participants: This cross-sectional study included 32 participants with AD who were 65 years or older and met diagnostic criteria for dementia due to probable AD with a score of at least 17 on the Mini-Mental State Examination and 16 age-matched control participants...
October 25, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29071346/challenges-in-the-study-of-genetic-variants-of-comorbid-alcohol-use-disorder-and-major-depression
#11
Alexis C Edwards
No abstract text is available yet for this article.
October 25, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29071344/genetic-risk-variants-associated-with-comorbid-alcohol-dependence-and-major-depression
#12
Hang Zhou, Renato Polimanti, Bao-Zhu Yang, Qian Wang, Shizhong Han, Richard Sherva, Yaira Z Nuñez, Hongyu Zhao, Lindsay A Farrer, Henry R Kranzler, Joel Gelernter
Importance: Alcohol dependence (AD) and major depression (MD) are leading causes of disability that often co-occur. Genetic epidemiologic data have shown that AD and MD share a common possible genetic cause. The molecular nature of this shared genetic basis is poorly understood. Objectives: To detect genetic risk variants for comorbid AD and MD and to determine whether polygenic risk alleles are shared with neuropsychiatric traits or subcortical brain volumes. Design, Setting, and Participants: This genome-wide association study analyzed criterion counts of comorbid AD and MD in African American and European American data sets collected as part of the Yale-Penn study of the genetics of drug and alcohol dependence from February 14, 1999, to January 13, 2015...
October 25, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29071343/error-in-results
#13
(no author information available yet)
No abstract text is available yet for this article.
October 25, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29049554/genetic-association-of-major-depression-with-atypical-features-and-obesity-related-immunometabolic-dysregulations
#14
Yuri Milaneschi, Femke Lamers, Wouter J Peyrot, Bernhard T Baune, Gerome Breen, Abbas Dehghan, Andreas J Forstner, Hans J Grabe, Georg Homuth, Carol Kan, Cathryn Lewis, Niamh Mullins, Matthias Nauck, Giorgio Pistis, Martin Preisig, Margarita Rivera, Marcella Rietschel, Fabian Streit, Jana Strohmaier, Alexander Teumer, Sandra Van der Auwera, Naomi R Wray, Dorret I Boomsma, Brenda W J H Penninx
Importance: The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. Objective: To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin)...
October 18, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29049499/leveraging-molecular-genetic-approaches-to-yield-insights-into-major-depression-etiology-and-clinical-presentation
#15
Roseann E Peterson
No abstract text is available yet for this article.
October 18, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29049469/the-effectiveness-of-injectable-extended-release-naltrexone-vs-daily-buprenorphine-naloxone-for-opioid-dependence-a-randomized-clinical-noninferiority-trial
#16
Lars Tanum, Kristin Klemmetsby Solli, Zill-E-Huma Latif, Jurate Šaltyte Benth, Arild Opheim, Kamni Sharma-Haase, Peter Krajci, Nikolaj Kunøe
Importance: To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication treatment (OMT), currently the most commonly prescribed treatment for opioid dependence. Objective: To determine whether treatment with extended-release naltrexone will be as effective as daily buprenorphine hydrochloride with naloxone hydrochloride in maintaining abstinence from heroin and other illicit substances in newly detoxified individuals...
October 18, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29049482/a-test-of-the-transdiagnostic-dopamine-hypothesis-of-psychosis-using-positron-emission-tomographic-imaging-in-bipolar-affective-disorder-and-schizophrenia
#17
Sameer Jauhar, Matthew M Nour, Mattia Veronese, Maria Rogdaki, Ilaria Bonoldi, Matilda Azis, Federico Turkheimer, Philip McGuire, Allan H Young, Oliver D Howes
Importance: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective disorder and schizophrenia, in line with the research domain criteria approach. However, this hypothesis has not been directly examined in individuals diagnosed with bipolar disorder with psychosis. Objectives: To test whether dopamine synthesis capacity is elevated in bipolar disorder with psychosis and how this compares with schizophrenia and matched controls and to examine whether dopamine synthesis capacity is associated with psychotic symptom severity, irrespective of diagnostic class...
October 11, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29049438/mood-instability-and-reward-dysregulation-a-neurocomputational-model-of-bipolar-disorder
#18
Liam Mason, Eran Eldar, Robb B Rutledge
No abstract text is available yet for this article.
October 11, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29049431/dopamine-dysfunction-in-schizophrenia-and-bipolar-disorder-never-the-twain-shall-meet
#19
Dost Öngür
No abstract text is available yet for this article.
October 11, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29052736/death-by-gun-violence-a-public-health-crisis
#20
Howard Bauchner, Frederick P Rivara, Robert O Bonow, Neil M Bressler, Mary L Nora Disis, Stephan Heckers, S Andrew Josephson, Melina R Kibbe, Jay F Piccirillo, Rita F Redberg, John S Rhee, June K Robinson
No abstract text is available yet for this article.
October 9, 2017: JAMA Psychiatry
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