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JAMA Psychiatry

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https://www.readbyqxmd.com/read/30624573/assessing-brain-metabolism-with-7-t-proton-magnetic-resonance-spectroscopy-in-patients-with-first-episode-psychosis
#1
Anna M Wang, Subechhya Pradhan, Jennifer M Coughlin, Aditi Trivedi, Samantha L DuBois, Jeffrey L Crawford, Thomas W Sedlak, Fredrick C Nucifora, Gerald Nestadt, Leslie G Nucifora, David J Schretlen, Akira Sawa, Peter B Barker
Importance: The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain regions of a large population of human participants facilitates in vivo study of localized or diffusely altered brain metabolites in patients with first-episode psychosis (FEP) compared to healthy participants. Objective: To compare metabolite levels in 5 brain regions between patients with FEP (evaluated within 2 years of onset) and healthy controls, and to explore possible associations between targeted metabolite levels and neuropsychological test performance...
January 9, 2019: JAMA Psychiatry
https://www.readbyqxmd.com/read/30624557/association-of-hydroxylmethyl-glutaryl-coenzyme-a-reductase-inhibitors-l-type-calcium-channel-antagonists-and-biguanides-with-rates-of-psychiatric-hospitalization-and-self-harm-in-individuals-with-serious-mental-illness
#2
Joseph F Hayes, Andreas Lundin, Susanne Wicks, Glyn Lewis, Ian C K Wong, David P J Osborn, Christina Dalman
Importance: Drug repurposing is potentially cost-effective, low risk, and necessary in psychiatric drug development. The availability of large, routine data sets provides the opportunity to evaluate the potential for currently used medication to benefit people with serious mental illness (SMI). Objective: To determine whether hydroxylmethyl glutaryl coenzyme A reductase inhibitors (HMG-CoA RIs), L-type calcium channel (LTCC) antagonists, and biguanides are associated with reduced psychiatric hospitalization and self-harm in individuals with SMI...
January 9, 2019: JAMA Psychiatry
https://www.readbyqxmd.com/read/30624551/association-of-combined-naltrexone-and-ketamine-with-depressive-symptoms-in-a-case-series-of-patients-with-depression-and-alcohol-use-disorder
#3
Gihyun Yoon, Ismene L Petrakis, John H Krystal
No abstract text is available yet for this article.
January 9, 2019: JAMA Psychiatry
https://www.readbyqxmd.com/read/30601883/association-between-antidepressant-drug-use-and-hip-fracture-in-older-people-before-and-after-treatment-initiation
#4
Jon Brännström, Hugo Lövheim, Yngve Gustafson, Peter Nordström
Importance: Treatment with antidepressants has been associated with hip fracture. This association could restrict the treatment options, especially in older patients. Objective: To investigate the association between antidepressant drug treatment and hip fracture starting 1 year before the initiation of treatment. Design, Setting, and Participants: In this nationwide cohort study, 204 072 individuals in the Prescribed Drugs Register of Sweden's National Board of Health and Welfare aged 65 years or older who had a prescription of antidepressants filled between July 1, 2006, and December 31, 2011, were matched by birth year and sex to 1 control participant who was not prescribed antidepressants (for a total of 408 144 people in the register)...
January 2, 2019: JAMA Psychiatry
https://www.readbyqxmd.com/read/30601880/a-status-update-on-the-association-between-antidepressants-and-fractures-breaking-up
#5
Andrea Iaboni, Donovan T Maust
No abstract text is available yet for this article.
January 2, 2019: JAMA Psychiatry
https://www.readbyqxmd.com/read/30601878/patterns-of-nonsocial-and-social-cognitive-functioning-in-adults-with-autism-spectrum-disorder-a-systematic-review-and-meta-analysis
#6
Tjasa Velikonja, Anne-Kathrin Fett, Eva Velthorst
Importance: Many studies have investigated impairments in cognitive domains in adults with autism spectrum disorder (ASD). Yet, to date, a comprehensive overview on the patterns of cognitive functioning is lacking. Objective: To provide an overview of nonsocial and social cognitive functioning in various domains in adults with ASD, allowing for comparison of the severity of deficits between different domains. Data Sources: A literature search performed in an academic medical setting was conducted using PubMed, PsycINFO, Embase, and Medline databases with the combination of the following free-text and Medical Subject Headings where applicable: [cogniti* OR neurocogniti* OR neuropsycholog* OR executive function* OR IQ OR intelligence quotient OR social cognition OR emotion perception OR affect perception OR emotion recognition OR attribution OR ToM OR mentalising OR mentalizing OR prosody OR social knowledge OR mind reading OR social cue OR social judgment] AND [autis* OR ASD OR Asperger OR Asperger's OR PDD OR pervasive developmental disorder]...
January 2, 2019: JAMA Psychiatry
https://www.readbyqxmd.com/read/30601877/21st-century-genetics-in-psychiatric-residency-training-how-do-we-get-there
#7
Aaron D Besterman, Daniel Moreno-De-Luca, John I Nurnberger
No abstract text is available yet for this article.
January 2, 2019: JAMA Psychiatry
https://www.readbyqxmd.com/read/30586143/cognitive-impairment-and-depression-cause-consequence-or-coincidence
#8
D Chamith Halahakoon, Glyn Lewis, Jonathan P Roiser
No abstract text is available yet for this article.
December 26, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30586140/buprenorphine-deregulation-and-mainstreaming-treatment-for-opioid-use-disorder-x-the-x-waiver
#9
Kevin Fiscella, Sarah E Wakeman, Leo Beletsky
No abstract text is available yet for this article.
December 26, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30586134/association-of-maternal-and-paternal-depression-in-the-postnatal-period-with-offspring-depression-at-age-18-years
#10
Leticia Gutierrez-Galve, Alan Stein, Lucy Hanington, Jon Heron, Glyn Lewis, Christine O'Farrelly, Paul G Ramchandani
Importance: Paternal depression during the postnatal period has been associated with adverse child outcomes. Family environment has been reported as a pathway for risk transmission from fathers to children. The influence of paternal depression during the postnatal period on offspring depression remains to be clarified. Objective: To investigate the association between paternal depression in the postnatal period and offspring depression and explore potential mediating and moderating factors that influence any association between paternal and offspring depression...
December 26, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30586133/cognitive-performance-in-first-degree-relatives-of-individuals-with-vs-without-major-depressive-disorder-a-meta-analysis
#11
Lynn E MacKenzie, Rudolf Uher, Barbara Pavlova
Importance: Findings of cognitive impairment in major depressive disorder (MDD), including remitted MDD, raise the question whether impaired cognition is part of preexisting vulnerability rather than a consequence of MDD or its treatment. To our knowledge, no meta-analyses have been published on cognitive impairment in first-degree relatives of individuals with MDD. Objective: To compare cognitive performance between individuals with and without family history of MDD...
December 26, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30566197/implementing-measurement-based-care-in-behavioral-health-a-review
#12
Cara C Lewis, Meredith Boyd, Ajeng Puspitasari, Elena Navarro, Jacqueline Howard, Hannah Kassab, Mira Hoffman, Kelli Scott, Aaron Lyon, Susan Douglas, Greg Simon, Kurt Kroenke
Importance: Measurement-based care (MBC) is the systematic evaluation of patient symptoms before or during an encounter to inform behavioral health treatment. Despite MBC's demonstrated ability to enhance usual care by expediting improvements and rapidly detecting patients whose health would otherwise deteriorate, it is underused, with typically less than 20% of behavioral health practitioners integrating it into their practice. This narrative review addresses definitional issues, offers a concrete and evaluable operationalization of MBC fidelity, and summarizes the evidence base and utility of MBC...
December 19, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30566181/association-of-genetic-risk-factors-for-psychiatric-disorders-and-traits-of-these-disorders-in-a-swedish-population-twin-sample
#13
Mark J Taylor, Joanna Martin, Yi Lu, Isabell Brikell, Sebastian Lundström, Henrik Larsson, Paul Lichtenstein
Importance: Psychiatric traits associated with categorically defined psychiatric disorders are heritable and present to varying degrees in the general population. It is commonly assumed that diagnoses represent the extreme end of continuously distributed traits in the population, but this assumption has yet to be robustly tested for many psychiatric phenotypes. Objective: To assess whether genetic risk factors associated with psychiatric disorders are also associated with continuous variation in milder population traits...
December 19, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30566177/anxiety-depression-and-insomnia-among-adults-with-opioid-dependence-treated-with-extended-release-naltrexone-vs-buprenorphine-naloxone-a-randomized-clinical-trial-and-follow-up-study
#14
Zill-E-Huma Latif, Jurate Šaltyte Benth, Kristin Klemmetsby Solli, Arild Opheim, Nikolaj Kunoe, Peter Krajci, Kamni Sharma-Haase, Lars Tanum
Importance: Extended-release naltrexone (XR-NTX) is a promising alternative treatment of opioid addiction but has never been compared with opioid agonist treatment for effects on symptoms of anxiety, depression, and insomnia. Objective: To investigate whether XR-NTX unmasks or reinforces current comorbid symptoms of anxiety, depression, or insomnia compared with opioid agonist treatment. Design, Setting, and Participants: In this prospective randomized clinical trial, 159 men and women aged 18 to 60 years with opioid dependence were randomized to 12 weeks of treatment with either XR-NTX or combined buprenorphine-naloxone (BP-NLX) followed by a 9-month, open-label treatment study with participant choice of 1 of these 2 drugs...
December 19, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30540353/factors-associated-with-successful-medication-discontinuation-after-a-randomized-clinical-trial-of-relapse-prevention-in-first-episode-psychosis-a-10-year-follow-up
#15
Christy L M Hui, William G Honer, Edwin H M Lee, W C Chang, Sherry K W Chan, Eric Y H Chen
No abstract text is available yet for this article.
December 12, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30540352/real-time-mobile-monitoring-of-the-dynamic-associations-among-motor-activity-energy-mood-and-sleep-in-adults-with-bipolar-disorder
#16
Kathleen Ries Merikangas, Joel Swendsen, Ian B Hickie, Lihong Cui, Haochang Shou, Alison K Merikangas, Jihui Zhang, Femke Lamers, Ciprian Crainiceanu, Nora D Volkow, Vadim Zipunnikov
Importance: Biologic systems involved in the regulation of motor activity are intricately linked with other homeostatic systems such as sleep, feeding behavior, energy, and mood. Mobile monitoring technology (eg, actigraphy and ecological momentary assessment devices) allows the assessment of these multiple systems in real time. However, most clinical studies of mental disorders that use mobile devices have not focused on the dynamic associations between these systems. Objectives: To examine the directional associations among motor activity, energy, mood, and sleep using mobile monitoring in a community-identified sample, and to evaluate whether these within-day associations differ between people with a history of bipolar or other mood disorders and controls without mood disorders...
December 12, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30540351/antipsychotics-excess-deaths-and-paradoxes-of-child-psychiatry
#17
Barbara Geller
No abstract text is available yet for this article.
December 12, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30540347/association-of-antipsychotic-treatment-with-risk-of-unexpected-death-among-children-and-youths
#18
Wayne A Ray, C Michael Stein, Katherine T Murray, D Catherine Fuchs, Stephen W Patrick, James Daugherty, Kathi Hall, William O Cooper
Importance: Children and youths who are prescribed antipsychotic medications have multiple, potentially fatal, dose-related cardiovascular, metabolic, and other adverse events, but whether or not these medications are associated with an increased risk of death is unknown. Objective: To compare the risk of unexpected death among children and youths who are beginning treatment with antipsychotic or control medications. Design, Setting, and Participants: This retrospective cohort study was conducted from 1999 through 2014 and included Medicaid enrollees aged 5 to 24 years in Tennessee who had no diagnosis of severe somatic illness, schizophrenia or related psychoses, or Tourette syndrome or chronic tic disorder...
December 12, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30516817/harbingers-of-mental-disease-infections-associated-with-an-increased-risk-for-neuropsychiatric-illness-in-children
#19
Viviane Labrie, Lena Brundin
No abstract text is available yet for this article.
December 5, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30516814/a-nationwide-study-in-denmark-of-the-association-between-treated-infections-and-the-subsequent-risk-of-treated-mental-disorders-in-children-and-adolescents
#20
Ole Köhler-Forsberg, Liselotte Petersen, Christiane Gasse, Preben B Mortensen, Soren Dalsgaard, Robert H Yolken, Ole Mors, Michael E Benros
Importance: Infections have been associated with increased risks for mental disorders, such as schizophrenia and depression. However, the association between all infections requiring treatment and the wide range of mental disorders is unknown to date. Objective: To investigate the association between all treated infections since birth and the subsequent risk of development of any treated mental disorder during childhood and adolescence. Design, Setting, and Participants: Population-based cohort study using Danish nationwide registers...
December 5, 2018: JAMA Psychiatry
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