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JAMA Ophthalmology

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https://www.readbyqxmd.com/read/28617918/intravitreal-melphalan-for-treatment-of-primary-vitreoretinal-lymphoma-a-new-indication-for-an-old-drug
#1
Carol L Shields, Kareem Sioufi, Arman Mashayekhi, Jerry A Shields
No abstract text is available yet for this article.
June 15, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28617914/trends-in-fluoroquinolone-nonsusceptibility-among-coagulase-negative-staphylococcus-isolates-causing-endophthalmitis-1995-2016
#2
Jack D Stringham, Nidhi Relhan, Darlene Miller, Harry W Flynn
No abstract text is available yet for this article.
June 15, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28617913/a-woman-with-a-spot-in-her-vision
#3
Sidney M Gospe, Scott D Walter, M Tariq Bhatti
No abstract text is available yet for this article.
June 15, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28617905/incidence-of-presumed-silicone-oil-droplets-in-the-vitreous-cavity-after-intravitreal-bevacizumab-injection-with-insulin-syringes
#4
Rahul N Khurana, Louis K Chang, Travis C Porco
Importance: Intravitreal bevacizumab is a frequently used antivascular endothelial growth factor medication in the United States, but its off-label use is associated with risks associated with the compounding preparation. Objective: To determine the incidence of presumed silicone oil droplets after intravitreal bevacizumab was prepared in insulin syringes by a compounding pharmacy. Design, Setting, and Participants: A retrospective review was conducted of 60 patients who experienced intravitreal silicone oil droplets in the eye after intravitreal bevacizumab injections from a single specialist practice from October 1, 2015, to November 30, 2016...
June 15, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28594986/error-in-text
#5
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28594985/use-of-structural-end-points-in-glaucoma-beyond-visual-field-loss
#6
Rohit Varma, Xuejuan Jiang
No abstract text is available yet for this article.
June 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28594982/bilateral-retinal-problem-in-a-patient-with-alport-syndrome
#7
Sundeep K Kasi, Murtaza K Adam, David S Ehmann
No abstract text is available yet for this article.
June 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28594979/use-of-corneal-confocal-microscopy-to-evaluate-small-nerve-fibers-in-patients-with-human-immunodeficiency-virus
#8
Harriet I Kemp, Ioannis N Petropoulos, Andrew S C Rice, Jan Vollert, Christoph Maier, Dietrich Strum, Marc Schargus, Tunde Peto, Scott Hau, Reena Chopra, Rayaz A Malik
Importance: Objective quantification of small fiber neuropathy in patients with human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) is difficult but needed for diagnosis and monitoring. In vivo corneal confocal microscopy (IVCCM) can quantify small fiber damage. Objective: To establish whether IVCCM can identify an abnormality in corneal nerve fibers and Langerhans cells in patients with and without HIV-SN. Design, Setting, and Participants: This prospective, cross-sectional cohort study was conducted between July 24, 2015, and September 17, 2015...
June 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28594977/association-of-glaucoma-related-optical-coherence-tomography-measured-macular-damage-with-vision-related-quality-of-life
#9
Alisa J Prager, Donald C Hood, Jeffrey M Liebmann, C Gustavo De Moraes, Lama A Al-Aswad, Qi Yu, George A Cioffi, Dana M Blumberg
Importance: Little is known about the association between structural macular damage and self-reported visual function of people with glaucoma. Objective: To determine the association between vision-related quality of life among patients with primary open-angle glaucoma with structural macular retinal ganglion cell plus inner plexiform layer (RGC+IPL) loss identified by spectral-domain optical coherence tomography (SD-OCT) machine-generated deviation maps and thickness measurements...
June 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28594973/patient-coauthored-history-could-improve-health-record-accuracy
#10
Michael John Warner
No abstract text is available yet for this article.
June 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28570740/chorioretinal-lesions-and-symptoms-of-elevated-intracranial-pressure
#11
Saaquib R Bakhsh, Mohsin H Ali, Pooja Bhat
No abstract text is available yet for this article.
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28570735/accuracy-of-billing-codes-used-in-the-therapeutic-care-of-diabetic-retinopathy
#12
Marisa Lau, Jonathan L Prenner, Alexander J Brucker, Brian L VanderBeek
Importance: Insurance billing claim databases represent a growing field of scientific inquiry within ophthalmology. Validating the accuracy of billing claim codes used during the care of diabetic retinopathy is a necessary precursor to fully understanding the underlying data and subsequent results of these types of studies. Objective: To determine the accuracy of diagnostic, procedural, and therapeutic billing codes used in the treatment of diabetic retinopathy...
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28570733/results-of-a-randomized-clinical-trial-of-aflibercept-vs-panretinal-photocoagulation-for-proliferative-diabetic-retinopathy-is-it-time-to-retire-your-laser
#13
https://www.readbyqxmd.com/read/28570731/consensus-on-diagnostic-criteria-of-idiopathic-orbital-inflammation-using-a-modified-delphi-approach
#14
Ilse Mombaerts, Jurij R Bilyk, Geoffrey E Rose, Alan A McNab, Aaron Fay, Peter J Dolman, Richard C Allen, Martin H Devoto, Gerald J Harris
Importance: Current practice to diagnose idiopathic orbital inflammation (IOI) is inconsistent, leading to frequent misdiagnosis of other orbital entities, including cancer. By specifying criteria, diagnosis of orbital inflammation will be improved. Objective: To define a set of criteria specific for the diagnosis of IOI. Design, Setting, and Participants: A 3-round modified Delphi process with an expert panel was conducted from June 8, 2015, to January 25, 2016...
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28570729/tyrosine-kinase-inhibitors-in-age-related-macular-degeneration
#15
Rajendra S Apte
No abstract text is available yet for this article.
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28570723/oral-tyrosine-kinase-inhibitor-for-neovascular-age-related-macular-degeneration-a-phase-1-dose-escalation-study
#16
Timothy L Jackson, David Boyer, David M Brown, Nauman Chaudhry, Michael Elman, Chris Liang, Denis O'Shaughnessy, Edward C Parsons, Sunil Patel, Jason S Slakter, Philip J Rosenfeld
Importance: An oral treatment for neovascular age-related macular degeneration would be less burdensome than repeated intravitreous injections. X-82 is an oral tyrosine kinase inhibitor active against vascular endothelial growth factor (VEGF) and platelet-derived growth factor. Objective: To undertake safety testing of oral X-82 administered for the treatment of neovascular AMD. Design, Setting, and Participants: Phase 1, open-label, uncontrolled, dose-escalation study at 5 US retinal clinics between November 2012 and March 2015 (Retina-Vitreous Associates Medical Group, Beverly Hills, California; Blanton Eye Institute, Houston Methodist Hospital, Retina Consultants of Houston, Houston, Texas; New England Retina Associates, Guilford, Connecticut; Elman Retina Group, Baltimore, Maryland; and Retina Research Institute of Texas, Abilene)...
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28570722/use-of-corneal-confocal-microscopy-to-detect-corneal-nerve-loss-and-increased-dendritic-cells-in-patients-with-multiple-sclerosis
#17
Gulfidan Bitirgen, Zehra Akpinar, Rayaz A Malik, Ahmet Ozkagnici
Importance: Multiple sclerosis (MS) is characterized by demyelination, axonal degeneration, and inflammation. Corneal confocal microscopy has been used to identify axonal degeneration in several peripheral neuropathies. Objective: To assess corneal subbasal nerve plexus morphologic features, corneal dendritic cell (DC) density, and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with MS. Design, Setting, and Participants: This single-center, cross-sectional comparative study was conducted at a tertiary referral university hospital between May 27, 2016, and January 30, 2017...
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28542697/incidence-of-atrophic-lesions-in-stargardt-disease-in-the-progression-of-atrophy-secondary-to-stargardt-disease-progstar-study-report-no-5
#18
Rupert W Strauss, Beatriz Muñoz, Alex Ho, Anamika Jha, Michel Michaelides, Saddek Mohand-Said, Artur V Cideciyan, David Birch, Amir H Hariri, Muneeswar G Nittala, SriniVas Sadda, Hendrik P N Scholl
Importance: Outcome measures that are sensitive to disease progression are needed as clinical end points for future treatment trials in Stargardt disease. Objective: To examine the incidence of atrophic lesions of the retinal pigment epithelium in patients with Stargardt disease as determined by fundus autofluorescence imaging. Design, Setting, and Participants: In this retrospective multicenter cohort study, 217 patients 6 years and older at baseline at tertiary referral centers in Europe, the United States, and the United Kingdom who were harboring disease-causing variants in the adenosine triphosphate (ATP)-binding cassette subfamily A member 4 (ABCA4) gene and who met the following criteria were enrolled: (1) at least 1 well-demarcated area of atrophy with a minimum diameter of 300 µm, with the total area of all atrophic lesions being less than or equal to 12 mm2 in at least 1 eye at the most recent visit, and (2) fundus autofluorescence images for at least 2 visits with a minimum of 6 months between at least 2 visits...
May 25, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28542696/incorporating-clinical-histological-and-genetic-parameters-for-choroidal-melanoma-prognostication
#19
Sarah E Coupland, Azzam Taktak, Bertil Damato
No abstract text is available yet for this article.
May 25, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28542693/macular-sensitivity-measured-with-microperimetry-in-stargardt-disease-in-the-progression-of-atrophy-secondary-to-stargardt-disease-progstar-study-report-no-7
#20
Etienne M Schönbach, Yulia Wolfson, Rupert W Strauss, Mohamed A Ibrahim, Xiangrong Kong, Beatriz Muñoz, David G Birch, Artur V Cideciyan, Gesa-Astrid Hahn, Muneeswar Nittala, Janet S Sunness, SriniVas R Sadda, Sheila K West, Hendrik P N Scholl
Importance: New outcome measures for treatment trials for Stargardt disease type 1 (STGD1) and other macular diseases are needed. Microperimetry allows mapping of light sensitivity of the macula and provides topographic information on visual function beyond visual acuity. Objective: To measure and analyze retinal light sensitivity of the macula in STGD1 using fundus-controlled perimetry (microperimetry). Design, Setting, and Participants: This was a multicenter prospective cohort study...
May 25, 2017: JAMA Ophthalmology
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