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JAMA Neurology

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https://www.readbyqxmd.com/read/29459985/when-do-%C3%AE-synucleinopathies-start-an-epidemiological-timeline-a-review
#1
Rodolfo Savica, Boeve F Bradley, Michelle M Mielke
Importance: This article reviews the epidemiological evidence of features of α-synucleinopathies that precede clinical onset of disease, proposes a clinical timeline, and attempts to define the different premotor and clinical phenotypes associated with α-synucleinopathies. Observations: The pathological hallmarks of the α-synucleinopathies (Parkinson disease, Parkinson disease dementia, dementia with Lewy bodies, and multisystem atrophy) begin years before a clinical diagnosis...
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29459981/association-between-prenatal-valproate-exposure-and-performance-on-standardized-language-and-mathematics-tests-in-school-aged-children
#2
Lars Skou Elkjær, Bodil Hammer Bech, Yuelian Sun, Thomas Munk Laursen, Jakob Christensen
Importance: Valproate sodium is used for the treatment of epilepsy and other neuropsychiatric disorders in women of childbearing potential. However, there are concerns about impaired cognitive development in children who have been exposed to valproate during pregnancy. Objective: To estimate the association between long-term school performance and prenatal exposure to valproate and a number of other antiepileptic drugs (AEDs). Design, Setting, and Participants: In a prospective, population-based cohort study conducted from August 1, 2015, to May 31, 2017, data used in the study were provided by Statistics Denmark on April 15, 2016...
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29459976/restoring-order-to-postoperative-neurocognitive-disorders
#3
Sarah Saxena, Yosuke Uchida, Mervyn Maze
No abstract text is available yet for this article.
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29459944/association-of-changes-in-plasma-neurofilament-light-and-tau-levels-with-anesthesia-and-surgery-results-from-the-capacity-and-arcadian-studies
#4
Lisbeth Evered, Brendan Silbert, David A Scott, Henrik Zetterberg, Kaj Blennow
Importance: Anesthesia and surgery are believed to act on the central nervous system by a fully reversible mechanism innocuous to nerve cells. Evidence that neurological sequelae may follow would challenge this belief and would thereby suggest a need to reassess theories of the mechanism of anesthetic action or the response of the central nervous system to surgery. Objective: To measure 2 biomarkers of neurological injury (neurofilament light and tau) in plasma in a series of timed collections before and after anesthesia and surgery...
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29459943/association-of-epidural-stimulation-with-cardiovascular-function-in-an-individual-with-spinal-cord-injury
#5
Christopher R West, Aaron A Phillips, Jordan W Squair, Alexandra M Williams, Matthias Walter, Tania Lam, Andrei V Krassioukov
No abstract text is available yet for this article.
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29459938/antiepileptic-drugs-in-pregnancy-quick-decisions-with-long-term-consequences
#6
Page B Pennell
No abstract text is available yet for this article.
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435583/mirror-movements-in-a-patient-with-brain-tumor
#7
Leon D Kaulen, Joachim M Baehring
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435581/error-in-data-presentation
#8
(no author information available yet)
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435570/tau-positron-emission-tomography-in-autosomal-dominant-alzheimer-disease-small-windows-big-picture
#9
Eric McDade, Randall J Bateman
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435569/interpreting-genetic-variants-in-titin-in-patients-with-muscle-disorders
#10
Marco Savarese, Lorenzo Maggi, Anna Vihola, Per Harald Jonson, Giorgio Tasca, Lucia Ruggiero, Luca Bello, Francesca Magri, Teresa Giugliano, Annalaura Torella, Anni Evilä, Giuseppina Di Fruscio, Olivier Vanakker, Sara Gibertini, Liliana Vercelli, Alessandra Ruggieri, Carlo Antozzi, Helena Luque, Sandra Janssens, Maria Barbara Pasanisi, Chiara Fiorillo, Monika Raimondi, Manuela Ergoli, Luisa Politano, Claudio Bruno, Anna Rubegni, Marika Pane, Filippo M Santorelli, Carlo Minetti, Corrado Angelini, Jan De Bleecker, Maurizio Moggio, Tiziana Mongini, Giacomo Pietro Comi, Lucio Santoro, Eugenio Mercuri, Elena Pegoraro, Marina Mora, Peter Hackman, Bjarne Udd, Vincenzo Nigro
Importance: Mutations in the titin gene (TTN) cause a wide spectrum of genetic diseases. The interpretation of the numerous rare variants identified in TTN is a difficult challenge given its large size. Objective: To identify genetic variants in titin in a cohort of patients with muscle disorders. Design, Setting, and Participants: In this case series, 9 patients with titinopathy and 4 other patients with possibly disease-causing variants in TTN were identified...
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435564/future-of-neurologic-examination-in-clinical-practice
#11
Luca Marsili, Alberto J Espay, Aristide Merola
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435562/future-of-neurologic-examination-in-clinical-practice-reply
#12
Michael J Aminoff
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435561/future-of-neurologic-examination-in-clinical-practice
#13
Laurence Bindoff
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435559/future-of-neurologic-examination-in-clinical-practice
#14
Steven J Frucht
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435558/association-between-amyloid-and-tau-accumulation-in-young-adults-with-autosomal-dominant-alzheimer-disease
#15
Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnson
Importance: It is critically important to improve our ability to diagnose and track Alzheimer disease (AD) as early as possible. Individuals with autosomal dominant forms of AD can provide clues as to which and when biological changes are reliably present prior to the onset of clinical symptoms. Objective: To characterize the associations between amyloid and tau deposits in the brains of cognitively unimpaired and impaired carriers of presenilin 1 (PSEN1) E280A mutation...
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29435554/understanding-titin-variants-in-the-age-of-next-generation-sequencing-a-titanic-challenge
#16
Carsten G Bönnemann
No abstract text is available yet for this article.
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29404583/differences-in-the-reponses-to-apheresis-therapy-of-patients-with-3-histopathologically-classified-immunopathological-patterns-of-multiple-sclerosis
#17
Lidia Stork, David Ellenberger, Tim Beißbarth, Tim Friede, Claudia F Lucchinetti, Wolfgang Brück, Imke Metz
Importance: Plasma exchange and immunoadsorption are second-line apheresis therapies for patients experiencing multiple sclerosis relapses. Early active multiple sclerosis lesions can be classified into different histopathological patterns of demyelination. Pattern 1 and 2 lesions show T-cell- and macrophage-associated demyelination, and pattern 2 is selectively associated with immunoglobulin and complement deposits, suggesting a humoral immune response. Pattern 3 lesions show signs of oligodendrocyte degeneration...
February 5, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29404581/evolution-of-unilateral-basal-ganglia-lesion-over-16-months
#18
Xin Lou, Chenglin Tian, Lin Ma
No abstract text is available yet for this article.
February 5, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29404578/quality-of-care-for-veterans-with-transient-ischemic-attack-and-minor-stroke
#19
Dawn M Bravata, Laura J Myers, Greg Arling, Edward J Miech, Teresa Damush, Jason J Sico, Michael S Phipps, Alan J Zillich, Zhangsheng Yu, Mathew Reeves, Linda S Williams, Jason Johanning, Seemant Chaturvedi, Fitsum Baye, Susan Ofner, Curt Austin, Jared Ferguson, Glenn D Graham, Rachel Rhude, Chad S Kessler, Donald S Higgins, Eric Cheng
Importance: The timely delivery of guideline-concordant care may reduce the risk of recurrent vascular events for patients with transient ischemic attack (TIA) and minor stroke. Although many health care organizations measure stroke care quality, few evaluate performance for patients with TIA or minor stroke, and most include only a limited subset of guideline-recommended processes. Objective: To assess the quality of guideline-recommended TIA and minor stroke care across the Veterans Health Administration (VHA) system nationwide...
February 5, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29404565/keeping-faith-with-patients-after-stroke-or-transient-ischemic-attack
#20
Walter N Kernan
No abstract text is available yet for this article.
February 5, 2018: JAMA Neurology
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