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JAMA Neurology

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https://www.readbyqxmd.com/read/28715558/prevalence-of-intracranial-aneurysm-in-women-with-fibromuscular-dysplasia-a-report-from-the-us-registry-for-fibromuscular-dysplasia
#1
Henry D Lather, Heather L Gornik, Jeffrey W Olin, Xiaokui Gu, Steven T Heidt, Esther S H Kim, Daniella Kadian-Dodov, Aditya Sharma, Bruce Gray, Michael R Jaff, Yung-Wei Chi, Pamela Mace, Eva Kline-Rogers, James B Froehlich
Importance: The prevalence of intracranial aneurysm in patients with fibromuscular dysplasia (FMD) is uncertain. Objective: To examine the prevalence of intracranial aneurysm in women diagnosed with FMD. Design, Setting, and Participants: This cross-sectional study included 669 women with intracranial imaging registered in the US Registry for Fibromuscular Dysplasia, an observational disease-based registry of patients with FMD confirmed by vascular imaging and currently enrolling at 14 participating US academic centers...
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28715552/large-perivascular-spaces-visible-on-magnetic-resonance-imaging-cerebral-small-vessel-disease-progression-and-risk-of-dementia-the-age-gene-environment-susceptibility-reykjavik-study
#2
Jie Ding, Sigurður Sigurðsson, Pálmi V Jónsson, Gudny Eiriksdottir, Andreas Charidimou, Oscar L Lopez, Mark A van Buchem, Vilmundur Guðnason, Lenore J Launer
Importance: With advancing age, an increased visibility of perivascular spaces (PVSs) on magnetic resonance imaging (MRI) is hypothesized to represent impaired drainage of interstitial fluid from the brain and may reflect underlying cerebral small vessel disease (SVD). However, whether large perivascular spaces (L-PVSs) (>3 mm in diameter) visible on MRI are associated with SVD and cognitive deterioration in older individuals is unknown. Objective: To examine whether L-PVSs are associated with the progression of the established MRI markers of SVD, cognitive decline, and increased risk of dementia...
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28715545/-bad-at-faces-a-prosopagnosic-s-tale
#3
Sarah Bugg
No abstract text is available yet for this article.
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28715541/cerebrospinal-fluid-examination-in-survivors-of-ebola-virus-disease
#4
Bridgette Jeanne Billioux, Avindra Nath, Eric J Stavale, Joseph Dorbor, Mosoka P Fallah, Michael C Sneller, Bryan R Smith
No abstract text is available yet for this article.
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28715536/neutropenia-in-patients-with-multiple-sclerosis-treated-with-alemtuzumab
#5
María Inés Gaitán, María Célica Ysrraelit, Jorge Correale
No abstract text is available yet for this article.
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28692730/secular-trends-of-amyotrophic-lateral-sclerosis-the-piemonte-and-valle-d-aosta-register
#6
Adriano Chiò, Gabriele Mora, Cristina Moglia, Umberto Manera, Antonio Canosa, Stefania Cammarosano, Antonio Ilardi, Davide Bertuzzo, Enrica Bersano, Paolo Cugnasco, Maurizio Grassano, Fabrizio Pisano, Letizia Mazzini, Andrea Calvo
Importance: This study reports the long-term epidemiologic trends of amyotrophic lateral sclerosis (ALS) based on a prospective register. Objective: To examine the 20-year epidemiologic trends of ALS in the Piemonte and Valle d'Aosta regions of Italy. Design, Setting, and Participants: The Piemonte and Valle d'Aosta Register for ALS (PARALS) is an epidemiologic prospective register that covers 2 Italian regions (population of 4 476 931 inhabitants according to the 2011 census) from January 1, 1995, through December 31, 2014...
July 10, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28692723/safety-of-converting-from-tetrabenazine-to-deutetrabenazine-for-the-treatment-of-chorea
#7
Samuel Frank, David Stamler, Elise Kayson, Daniel O Claassen, Amy Colcher, Charles Davis, Andrew Duker, Shirley Eberly, Lawrence Elmer, Erin Furr-Stimming, Mark Gudesblatt, Christine Hunter, Joseph Jankovic, Sandra K Kostyk, Rajeev Kumar, Clement Loy, William Mallonee, David Oakes, Burton L Scott, Victor Sung, Jody Goldstein, Christina Vaughan, Claudia M Testa
Importance: Tetrabenazine is efficacious for chorea control; however, tolerability concerns exist. Deutetrabenazine, a novel molecule that reduces chorea, was well tolerated in a double-blind, placebo-controlled study. Objectives: To evaluate the safety and explore the efficacy of conversion from tetrabenazine to deutetrabenazine in patients with chorea associated with Huntington disease (HD). Design, Setting, and Participants: In this ongoing, open-label, single-arm study that started on December 21, 2013, 37 patients at 13 Huntington Study Group sites in the United States and Australia who were taking stable doses of tetrabenazine that provided a therapeutic benefit were switched overnight to deutetrabenazine therapy...
July 10, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28692720/mechanical-thrombectomy-after-intravenous-thrombolysis-vs-mechanical-thrombectomy-alone-in-acute-stroke-reply
#8
Jonathan M Coutinho, Vitor M Pereira
No abstract text is available yet for this article.
July 10, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28692711/mechanical-thrombectomy-after-intravenous-thrombolysis-vs-mechanical-thrombectomy-alone-in-acute-stroke
#9
Pierre Seners, Catherine Oppenheim, Jean-Claude Baron
No abstract text is available yet for this article.
July 10, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28692710/association-of-plasma-total-tau-level-with-cognitive-decline-and-risk-of-mild-cognitive-impairment-or-dementia-in-the-mayo-clinic-study-on-aging
#10
Michelle M Mielke, Clinton E Hagen, Alexandra M V Wennberg, David C Airey, Rodolfo Savica, David S Knopman, Mary M Machulda, Rosebud O Roberts, Clifford R Jack, Ronald C Petersen, Jeffrey L Dage
Importance: The utility of plasma total tau level as a prognostic marker for cognitive decline and dementia is not well understood. Objectives: To determine (1) the association between plasma total tau level, cognitive decline, and risk of mild cognitive impairment (MCI) and dementia; (2) whether this association differs by the presence of elevated brain amyloid β (Aβ); and (3) whether plasma total tau level is associated with cognitive decline over a short interval of 15 months...
July 10, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28692708/safety-and-efficacy-of-bortezomib-in-patients-with-highly-relapsing-neuromyelitis-optica-spectrum-disorder
#11
Chao Zhang, De-Cai Tian, Chun-Sheng Yang, Bin Han, Jing Wang, Li Yang, Fu-Dong Shi
No abstract text is available yet for this article.
July 10, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28672395/association-between-motor-symptoms-and-brain-metabolism-in-early-huntington-disease
#12
Véronique Gaura, Sonia Lavisse, Pierre Payoux, Serge Goldman, Christophe Verny, Pierre Krystkowiak, Philippe Damier, Frédéric Supiot, Anne-Catherine Bachoud-Levi, Philippe Remy
Importance: Brain hypometabolism is associated with the clinical consequences of the degenerative process, but little is known about regional hypermetabolism, sometimes observed in the brain of patients with clinically manifest Huntington disease (HD). Studying the role of regional hypermetabolism is needed to better understand its interaction with the motor symptoms of the disease. Objective: To investigate the association between brain hypometabolism and hypermetabolism with motor scores of patients with early HD...
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28672374/reassuring-news-about-football-and-cognitive-decline-not-so-fast
#13
Allison R Kaup, Kristine Yaffe
No abstract text is available yet for this article.
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28672348/integration-of-advanced-practice-clinicians-in-neurology-practices
#14
Paula Hardeman, Rhonda Hough
No abstract text is available yet for this article.
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28672325/association-of-playing-high-school-football-with-cognition-and-mental-health-later-in-life
#15
Sameer K Deshpande, Raiden B Hasegawa, Amanda R Rabinowitz, John Whyte, Carol L Roan, Andrew Tabatabaei, Michael Baiocchi, Jason H Karlawish, Christina L Master, Dylan S Small
Importance: American football is the largest participation sport in US high schools and is a leading cause of concussion among adolescents. Little is known about the long-term cognitive and mental health consequences of exposure to football-related head trauma at the high school level. Objective: To estimate the association of playing high school football with cognitive impairment and depression at 65 years of age. Design, Setting, and Participants: A representative sample of male high school students who graduated from high school in Wisconsin in 1957 was studied...
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28672292/association-between-pregnancy-and-perinatal-outcomes-among-women-with-epilepsy
#16
Neda Razaz, Torbjörn Tomson, Anna-Karin Wikström, Sven Cnattingius
Importance: To date, few attempts have been made to examine associations between exposure to maternal epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perinatal outcomes. Objectives: To investigate associations between epilepsy in pregnancy and risks of pregnancy and perinatal outcomes as well as whether use of AEDs influenced risks. Design, Setting, and Participants: A population-based cohort study was conducted on all singleton births at 22 or more completed gestational weeks in Sweden from 1997 through 2011; of these, 1 424 279 were included in the sample...
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28672290/winning-the-fight-to-end-alzheimer-disease
#17
Walter Dawson
No abstract text is available yet for this article.
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28655059/association-of-autonomic-dysfunction-with-disease-progression-and-survival-in-parkinson-disease
#18
Eduardo De Pablo-Fernandez, Carmen Tur, Tamas Revesz, Andrew J Lees, Janice L Holton, Thomas T Warner
Importance: Evidence suggests that development of autonomic dysfunction (AutD) may negatively affect disease course and survival in patients with synucleinopathies. However, the few available studies on Parkinson disease (PD) have conflicting results, comprise a small number of patients, have short follow-up periods, and lack pathologic confirmation of the diagnosis. Objective: To examine the association of time of onset of AutD with disease progression and survival in PD...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28655027/zolpidem-for-the-treatment-of-neurologic-disorders-a-systematic-review
#19
Martin N Bomalaski, Edward S Claflin, Whitney Townsend, Mark D Peterson
Importance: Given its selective action on the ω1 subtype of the γ-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. Objective: To synthesize studies that used zolpidem to treat neurologic disorders. Evidence Review: Eligibility criteria included any published English-language article that examined the use of zolpidem for noninsomnia neurologic disorders in humans for all dates up to March 20, 2015...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28655026/potential-influence-of-fda-sponsored-studies-of-antiepilepsy-drugs-on-generic-and-brand-name-formulation-prescribing
#20
Gregory L Krauss
No abstract text is available yet for this article.
June 26, 2017: JAMA Neurology
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