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JAMA Neurology

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https://www.readbyqxmd.com/read/28531306/association-of-long-term-opioid-therapy-with-functional-status-adverse-outcomes-and-mortality-among-patients-with-polyneuropathy
#1
E Matthew Hoffman, James C Watson, Jennifer St Sauver, Nathan P Staff, Christopher J Klein
Importance: Polyneuropathy is one of the most common painful conditions managed within general and specialty clinics. Neuropathic pain frequently leads to decisions about using long-term opioid therapy. Understanding the association of long-term opioid use with functional status, adverse outcomes, and mortality among patients with polyneuropathy could influence disease-specific decisions about opioid treatment. Objectives: To quantify the prevalence of long-term opioid use among patients with polyneuropathy and to assess the association of long-term opioid use with functional status, adverse outcomes, and mortality...
May 22, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28531266/concerns-regarding-opicapone-as-adjunct-to-levodopa-therapy-reply
#2
Andrew J Lees, José-Francisco Rocha, Patricio Soares-da-Silva
No abstract text is available yet for this article.
May 22, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28531257/lack-of-evidence-for-benefit-from-long-term-use-of-opioid-analgesics-for-patients-with-neuropathy
#3
Nora D Volkow, Walter Koroshetz
No abstract text is available yet for this article.
May 22, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28531250/concerns-regarding-opicapone-as-adjunct-to-levodopa-therapy
#4
Yu Zhang, Xiaoming Huang
No abstract text is available yet for this article.
May 22, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28505267/integrating-models-of-neurologic-and-psychiatric-disease
#5
David Silbersweig
No abstract text is available yet for this article.
May 15, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28505261/survival-and-causes-of-death-among-people-with-clinically-diagnosed-synucleinopathies-with-parkinsonism-a-population-based-study
#6
Rodolfo Savica, Brandon R Grossardt, James H Bower, J Eric Ahlskog, Bradley F Boeve, Jonathan Graff-Radford, Walter A Rocca, Michelle M Mielke
Importance: To our knowledge, a comprehensive study of the survival and causes of death of persons with synucleinopathies compared with the general population has not been conducted. Understanding the long-term outcomes of these conditions may inform patients and caregivers of the expected disease duration and may help with care planning. Objective: To compare survival rates and causes of death among patients with incident, clinically diagnosed synucleinopathies and age- and sex-matched referent participants...
May 15, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28505243/association-of-dual-task-gait-with-incident-dementia-in-mild-cognitive-impairment-results-from-the-gait-and-brain-study
#7
Manuel M Montero-Odasso, Yanina Sarquis-Adamson, Mark Speechley, Michael J Borrie, Vladimir C Hachinski, Jennie Wells, Patricia M Riccio, Marcelo Schapira, Ervin Sejdic, Richard M Camicioli, Robert Bartha, William E McIlroy, Susan Muir-Hunter
Importance: Gait performance is affected by neurodegeneration in aging and has the potential to be used as a clinical marker for progression from mild cognitive impairment (MCI) to dementia. A dual-task gait test evaluating the cognitive-motor interface may predict dementia progression in older adults with MCI. Objective: To determine whether a dual-task gait test is associated with incident dementia in MCI. Design, Setting, and Participants: The Gait and Brain Study is an ongoing prospective cohort study of community-dwelling older adults that enrolled 112 older adults with MCI...
May 15, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28505236/could-albumin-be-a-biomarker-to-monitor-the-effect-of-intravenous-immunoglobulin-on-guillain-barr%C3%A3-syndrome-reply
#8
Willem-Jan R Fokkink, Bart C Jacobs
No abstract text is available yet for this article.
May 15, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28505216/could-albumin-be-a-biomarker-to-monitor-the-effect-of-intravenous-immunoglobulin-on-guillain-barr%C3%A3-syndrome
#9
Ying Wang, Hong-Liang Zhang
No abstract text is available yet for this article.
May 15, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28492932/population-based-prevalence-of-cerebral-cavernous-malformations-in-older-adults-mayo-clinic-study-of-aging
#10
Kelly D Flemming, Jonathan Graff-Radford, Jeremiah Aakre, Kejal Kantarci, Giuseppe Lanzino, Robert D Brown, Michelle M Mielke, Rosebud O Roberts, Walter Kremers, David S Knopman, Ronald C Petersen, Clifford R Jack
Importance: The prevalence of cerebral cavernous malformation (CCM) is unknown. Case ascertainment in most previous studies was based on autopsy data or clinical convenience samples, often without detailed clinical or radiologic information. Objective: To determine the prevalence of CCM in a population-based sample of older adults. Design, Setting, and Participants: This prospective imaging study included 4721 participants aged 50 to 89 years who were enrolled between January 1, 2004, and December 15, 2015, in the Mayo Clinic Study of Aging, a longitudinal, population-based study of residents of Olmsted County, Minnesota...
May 8, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28492918/association-of-a-primary-stroke-center-protocol-for-suspected-stroke-by-large-vessel-occlusion-with-efficiency-of-care-and-patient-outcomes
#11
Ryan A McTaggart, Shadi Yaghi, Shawna M Cutting, Morgan Hemendinger, Grayson L Baird, Richard A Haas, Karen L Furie, Mahesh V Jayaraman
Importance: While prehospital triage to the closest comprehensive stroke center (CSC) may improve the delivery of care for patients with suspected emergent large-vessel occlusion (ELVO), efficient systems of care must also exist for patients with ELVO who first present to a primary stroke center (PSC). Objective: To describe the association of a PSC protocol focused on 3 key steps (early CSC notification based on clinical severity, vessel imaging at the PSC, and cloud-based image sharing) with the efficiency of care and the outcomes of patients with suspected ELVO who first present to a PSC...
May 8, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28492857/inappropriate-comparator-group-in-study-of-selective-serotonin-reuptake-inhibitors-and-risk-for-intracranial-hemorrhage-reply
#12
Christel Renoux, Sophie Dell'Aniello, Jean-François Boivin
No abstract text is available yet for this article.
May 8, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28492832/dementia-care-women-s-health-and-gender-equity-the-value-of-well-timed-caregiver-support
#13
Nicholas T Bott, Clifford C Sheckter, Arnold S Milstein
No abstract text is available yet for this article.
May 8, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28492819/inappropriate-comparator-group-in-study-of-selective-serotonin-reuptake-inhibitors-and-risk-for-intracranial-hemorrhage
#14
David Jeffrey Beale
No abstract text is available yet for this article.
May 8, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28492814/implementation-of-rapid-treatment-and-interfacility-transport-for-patients-with-suspected-stroke-by-large-vessel-occlusion-in-one-door-and-out-the-other
#15
Kori Sauser Zachrison, Lee H Schwamm
No abstract text is available yet for this article.
May 8, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28460032/association-of-retinal-architecture-intrathecal-immunity-and-clinical-course-in-multiple-sclerosis
#16
Benjamin Knier, Gildas Leppenetier, Carmen Wetzlmair, Lilian Aly, Muna-Miriam Hoshi, Verena Pernpeintner, Viola Biberacher, Achim Berthele, Mark Mühlau, Claus Zimmer, Bernhard Hemmer, Thomas Korn
Importance: Biomarkers to estimate long-term outcomes in patients with multiple sclerosis (MS) and to assign patients to individual treatment regimens are urgently needed. Objective: To assess whether retinal layer volumes are correlated with immune cell subsets and immunoglobulin indices in the cerebrospinal fluid and whether retinal layer volumes alone or in combination with intrathecal variables are associated with worsening of disease in patients with relapsing-remitting MS...
May 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28459965/functional-decline-5-years-after-blast-traumatic-brain-injury-sounding-the-alarm-for-a-wave-of-disability
#17
Kristen Dams-O'Connor, Jack W Tsao
No abstract text is available yet for this article.
May 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28459962/common-myths-in-the-use-of-levodopa-in-parkinson-disease-when-clinical-trials-misinform-clinical-practice
#18
Alberto J Espay, Anthony E Lang
No abstract text is available yet for this article.
May 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28459953/early-clinical-predictors-of-5-year-outcome-after-concussive-blast-traumatic-brain-injury
#19
Christine L Mac Donald, Jason Barber, Mary Jordan, Ann M Johnson, Sureyya Dikmen, Jesse R Fann, Nancy Temkin
Importance: The long-term clinical effects of wartime traumatic brain injuries (TBIs), most of which are mild, remain incompletely described. Current medical disability cost estimates from world conflicts continually surpass projections. Additional information regarding long-term functional trajectory is needed to reduce this extensive public health burden. Objectives: To examine 5-year clinical outcomes leveraging existing clinical data collected at 1 year after injury in the same patients and to identify early risk factors for long-term disability...
May 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28459949/ascertainment-bias-in-statin-use-and-alzheimer-disease-incidence
#20
D Michal Freedman, Ruth M Pfeiffer
No abstract text is available yet for this article.
May 1, 2017: JAMA Neurology
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