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JAMA Neurology

Dena B Dubal, Samuel J Pleasure
No abstract text is available yet for this article.
January 14, 2019: JAMA Neurology
Eduardo De Pablo-Fernández, Andrew J Lees, Janice L Holton, Thomas T Warner
Importance: Clinical subtyping of Parkinson disease at diagnosis is useful in estimating disease course and survival. Severity and rate of progression of neuropathologies are important determinants of clinical Parkinson subtypes. Objective: To provide longitudinal clinical disease-course data and neuropathologic correlation for newly proposed Parkinson disease subtypes. Design, Setting, and Participants: Retrospective cohort study of consecutive patients with autopsy-confirmed Parkinson disease who were regularly seen throughout their disease course by hospital specialists in the United Kingdom and donated their brain at death to the Queen Square Brain Bank between January 2009 and December 2017...
January 14, 2019: JAMA Neurology
Gustaf Brander, Kayoko Isomura, Zheng Chang, Ralf Kuja-Halkola, Catarina Almqvist, Henrik Larsson, David Mataix-Cols, Lorena Fernández de la Cruz
Importance: There are limited data concerning the risk of metabolic and cardiovascular disorders among individuals with Tourette syndrome (TS) or chronic tic disorder (CTD). Objective: To investigate the risk of metabolic and cardiovascular disorders among individuals with TS or CTD over a period of 40 years. Design, Settings, and Participants: This longitudinal population-based cohort study included all individuals living in Sweden between January 1, 1973, and December 31, 2013...
January 14, 2019: JAMA Neurology
Dilan Athauda, Seema Gulyani, Hanuma Karnati, Yazhou Li, David Tweedie, Maja Mustapic, Sahil Chawla, Kashfia Chowdhury, Simon S Skene, Nigel H Greig, Dimitrios Kapogiannis, Thomas Foltynie
Importance: Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was recently found to have beneficial effects on motor function in a randomized, placebo-controlled trial in Parkinson disease (PD). Accumulating evidence suggests that impaired brain insulin and protein kinase B (Akt) signaling play a role in PD pathogenesis; however, exploring the extent to which drugs engage with putative mechnisms in vivo remains a challenge. Objective: To assess whether participants in the Exenatide-PD trial have augmented activity in brain insulin and Akt signaling pathways...
January 14, 2019: JAMA Neurology
Anna M M Boers, Ivo G H Jansen, Scott Brown, Hester F Lingsma, Ludo F M Beenen, Thomas G Devlin, Luis San Román, Ji-Hoe Heo, Marc Ribó, Mohammed A Almekhlafi, David S Liebeskind, Jeanne Teitelbaum, Patricia Cuadras, Richard du Mesnil de Rochemont, Marine Beaumont, Martin M Brown, Albert J Yoo, Geoffrey A Donnan, Jean Louis Mas, Catherine Oppenheim, Richard J Dowling, Thierry Moulin, Nelly Agrinier, Demetrius K Lopes, Lucía Aja Rodríguez, Kars C J Compagne, Fahad S Al-Ajlan, Jeremy Madigan, Gregory W Albers, Sebastien Soize, Jordi Blasco, Stephen M Davis, Raul G Nogueira, Antoni Dávalos, Bijoy K Menon, Aad van der Lugt, Keith W Muir, Yvo B W E M Roos, Phil White, Peter J Mitchell, Andrew M Demchuk, Wim H van Zwam, Tudor G Jovin, Robert J van Oostenbrugge, Diederik W J Dippel, Bruce C V Campbell, Francis Guillemin, Serge Bracard, Michael D Hill, Mayank Goyal, Henk A Marquering, Charles B L M Majoie
Importance: The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke. Objective: To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke. Design, Setting, and Participants: Patient data from 7 randomized multicenter trials were pooled...
January 7, 2019: JAMA Neurology
John C Morris, Suzanne E Schindler, Lena M McCue, Krista L Moulder, Tammie L S Benzinger, Carlos Cruchaga, Anne M Fagan, Elizabeth Grant, Brian A Gordon, David M Holtzman, Chengjie Xiong
Importance: Racial differences in molecular biomarkers for Alzheimer disease may suggest race-dependent biological mechanisms. Objective: To ascertain whether there are racial disparities in molecular biomarkers for Alzheimer disease. Design, Setting, and Participants: A total of 1255 participants (173 African Americans) were enrolled from January 1, 2004, through December 31, 2015, in longitudinal studies at the Knight Alzheimer Disease Research Center at Washington University and completed a magnetic resonance imaging study of the brain and/or positron emission tomography of the brain with Pittsburgh compound B (radioligand for aggregated amyloid-β) and/or cerebrospinal fluid (CSF) assays for the concentrations of amyloid-β42, total tau, and phosphorylated tau181...
January 7, 2019: JAMA Neurology
Lisa L Barnes
No abstract text is available yet for this article.
January 7, 2019: JAMA Neurology
Yvonne Naegelin, Peter Naegelin, Stefanie von Felten, Johannes Lorscheider, Judith Sonder, Bernard M J Uitdehaag, Barbara Scotti, Chiara Zecca, Claudio Gobbi, Ludwig Kappos, Tobias Derfuss
Importance: Therapeutic options for patients with secondary progressive multiple sclerosis (SPMS) are limited. Objective: To analyze disability progression in patients with SPMS treated with rituximab compared with matched control patients never treated with rituximab. Design, Setting, and Participants: This retrospective cohort study analyzed data obtained from patients with SPMS at 3 multiple sclerosis centers located in Basel and Lugano, Switzerland, and Amsterdam, the Netherlands, from 2004 to 2017...
January 7, 2019: JAMA Neurology
Marc Paul O'Sullivan, Ann Marie Looney, Gerard M Moloney, Mikael Finder, Boubou Hallberg, Gerard Clarke, Geraldine B Boylan, Deirdre M Murray
Importance: Neonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of neurologic disability. Identifying infants suitable for therapeutic hypothermia (TH) within a narrow therapeutic time is difficult. No single robust biochemical marker is available to clinicians. Objective: To assess the ability of a panel of candidate microRNA (miRNA) to evaluate the development and severity of encephalopathy following perinatal asphyxia (PA). Design, Setting, and Participants: This validation study included 2 cohorts...
December 28, 2018: JAMA Neurology
(no author information available yet)
No abstract text is available yet for this article.
December 28, 2018: JAMA Neurology
Kimberley J Smith, Mark D Peterson, Neil E O'Connell, Christina Victor, Silvia Liverani, Nana Anokye, Jennifer M Ryan
Importance: Cerebral palsy (CP) is considered a pediatric condition despite most individuals with CP living into adulthood. Thus, there is a lack of evidence in adults with CP, which includes a paucity of research examining mental health in this population. Objectives: To determine the risk of depression and anxiety in adults with CP compared with an age-, sex-, and practice-matched reference group of adults without CP, using primary care data. Design, Setting, and Participants: Retrospective longitudinal cohort study set in UK primary care...
December 28, 2018: JAMA Neurology
Annemijn M Algra, Antti Lindgren, Mervyn D I Vergouwen, Jacoba P Greving, Irene C van der Schaaf, Tristan P C van Doormaal, Gabriel J E Rinkel
Importance: The risk of procedural clinical complications and the case-fatality rate (CFR) from preventive treatment of unruptured intracranial aneurysms varies between studies and may depend on treatment modality and risk factors. Objective: To assess current procedural clinical 30-day complications and the CFR from endovascular treatment (EVT) and neurosurgical treatment (NST) of unruptured intracranial aneurysms and risk factors of clinical complications. Data Sources: We searched PubMed, Excerpta Medica Database, and the Cochrane Database for studies published between January 1, 2011, and January 1, 2017...
December 28, 2018: JAMA Neurology
Divyanshu Dubey, Sean J Pittock, Karl N Krecke, Padraig P Morris, Elia Sechi, Nicholas L Zalewski, Brian G Weinshenker, Eslam Shosha, Claudia F Lucchinetti, James P Fryer, A Sebastian Lopez-Chiriboga, John C Chen, Jiraporn Jitprapaikulsan, Andrew McKeon, Avi Gadoth, B Mark Keegan, Jan-Mendelt Tillema, Elie Naddaf, Marc C Patterson, Kevin Messacar, Kenneth L Tyler, Eoin P Flanagan
Importance: Recognizing the characteristics of myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) myelitis is essential for early accurate diagnosis and treatment. Objective: To evaluate the clinical, radiologic, and prognostic features of MOG-IgG myelitis and compare with myelitis with aquaporin-4-IgG (AQP4-IgG) and multiple sclerosis (MS). Design, Setting, and Participants: We retrospectively identified 199 MOG-IgG-positive Mayo Clinic patients from January 1, 2000, through December 31, 2017, through our neuroimmunology laboratory...
December 21, 2018: JAMA Neurology
Elizabeth W Loder, Rebecca C Burch
No abstract text is available yet for this article.
December 21, 2018: JAMA Neurology
Lynne Rumping, Benjamin Büttner, Oliver Maier, Holger Rehmann, Maarten Lequin, Jan-Ulrich Schlump, Bernhard Schmitt, Birgit Schiebergen-Bronkhorst, Hubertus C M T Prinsen, Michele Losa, Ralph Fingerhut, Johannes R Lemke, Fried J T Zwartkruis, Roderick H J Houwen, Judith J M Jans, Nanda M Verhoeven-Duif, Peter M van Hasselt, Rami Jamra
Importance: The identification and understanding of the monogenic causes of neurodevelopmental disorders are of high importance for personalized treatment and genetic counseling. Objective: To identify and characterize novel genes for a specific neurodevelopmental disorder characterized by refractory seizures, respiratory failure, brain abnormalities, and death in the neonatal period; describe the outcome of glutaminase deficiency in humans; and understand the underlying pathological mechanisms...
December 21, 2018: JAMA Neurology
James A Charles
No abstract text is available yet for this article.
December 21, 2018: JAMA Neurology
Mayur Chalia, Thyagarajan Subramanian
No abstract text is available yet for this article.
December 21, 2018: JAMA Neurology
Wade Arthur, Jennifer Austin, Cole Wayant, Matt Vassar
No abstract text is available yet for this article.
December 17, 2018: JAMA Neurology
Pinar Kahraman-Koytak, Beau B Bruce, Jason H Peragallo, Nancy J Newman, Valérie Biousse
Importance: Diagnostic errors can lead to the initial misdiagnosis of optic nerve sheath meningiomas (ONSM), which can lead to vision loss. Objective: To identify factors contributing to the initial misdiagnosis of ONSM. Design, Setting, and Participants: We retrospectively reviewed 35 of 39 patients with unilateral ONSM (89.7%) who were seen in the tertiary neuro-ophthalmology practice at Emory University School of Medicine between January 2002 and March 2017...
December 17, 2018: JAMA Neurology
Karlo J Lizarraga, Philip D Thompson, Henry P Moore, Gabriel Mizraji, Oscar S Gershanik, Carlos Singer, Anthony E Lang
Importance: Recognized peripherally induced movement disorders include the painful legs moving toes syndrome, postamputation dyskinesias, and belly dancer dyskinesias. Objective: To introduce and characterize the dancing dorsal quadrilaterals, a novel peripherally induced movement disorder that predominantly affects dorsal quadrilateral muscles (trapezius and rhomboids) after upper spine instrumentation. Design, Setting, and Participants: Between 1990 and 2015, a total of 4 patients who developed abnormal movements of the dorsal quadrilateral muscles after upper spine instrumentation were referred to movement disorders clinics at 3 academic medical centers in the United States, Canada, and Argentina...
December 17, 2018: JAMA Neurology
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