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JAMA Neurology

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https://www.readbyqxmd.com/read/28097330/electroencephalographic-periodic-discharges-and-frequency-dependent-brain-tissue-hypoxia-in-acute-brain-injury
#1
Jens Witsch, Hans-Peter Frey, J Michael Schmidt, Angela Velazquez, Cristina M Falo, Michael Reznik, David Roh, Sachin Agarwal, Soojin Park, E Sander Connolly, Jan Claassen
Importance: Periodic discharges (PDs) that do not meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroencephalographic (EEG) recordings after acute brain injury. However, their association with brain homeostasis and the need for clinical intervention remain unknown. Objective: To determine whether distinct PD patterns can be identified that, similar to electrographic seizures, cause brain tissue hypoxia, a measure of ongoing brain injury...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28097310/combined-intravenous-thrombolysis-and-thrombectomy-vs-thrombectomy-alone-for-acute-ischemic-stroke-a-pooled-analysis-of-the-swift-and-star-studies
#2
Jonathan M Coutinho, David S Liebeskind, Lee-Anne Slater, Raul G Nogueira, Wayne Clark, Antoni Dávalos, Alain Bonafé, Reza Jahan, Urs Fischer, Jan Gralla, Jeffrey L Saver, Vitor M Pereira
Importance: Mechanical thrombectomy (MT) improves clinical outcomes in patients with acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known whether intravenous thrombolysis (IVT) is of added benefit in patients undergoing MT. Objective: To examine whether treatment with IVT before MT with a stent retriever is beneficial in patients undergoing MT. Design, Setting, and Participants: This post hoc analysis used data from 291 patients treated with MT included in 2 large, multicenter, prospective clinical trials that evaluated MT for AIS (Solitaire With the Intention for Thrombectomy performed from January 1, 2010, through December 31, 2011, and Solitaire Flow Restoration Thrombectomy for Acute Revascularization from January 1, 2010, through December 31, 2012)...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28097308/mechanical-thrombectomy-for-acute-ischemic-stroke-are-we-done
#3
Gursant S Atwal, Adnan H Siddiqui
No abstract text is available yet for this article.
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28097307/association-of-periodic-discharges-with-reduced-brain-tissue-oxygenation-no-longer-straddling-the-fence
#4
Brian D Moseley
No abstract text is available yet for this article.
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28097302/association-of-extension-of-cervical-cord-lesion-and-area-postrema-syndrome-with-neuromyelitis-optica-spectrum-disorder
#5
Divyanshu Dubey, Sean J Pittock, Karl N Krecke, Eoin P Flanagan
No abstract text is available yet for this article.
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28055081/soluble-cd27-levels-in-cerebrospinal-fluid-as-a-prognostic-biomarker-in-clinically-isolated-syndrome
#6
Roos M van der Vuurst de Vries, Julia Y Mescheriakova, Tessel F Runia, Naghmeh Jafari, Theodora A M Siepman, Rogier Q Hintzen
Importance: There is a growing number of therapies that could be administered after the first symptom of central nervous system demyelination. These drugs can delay multiple sclerosis (MS) diagnosis and slow down future disability. However, treatment of patients with benign course may not be needed; therefore, there is a need for biomarkers to predict long-term prognosis in patients with clinically isolated syndrome (CIS). Objective: To investigate whether the T-cell activation marker soluble CD27 (sCD27) measured in cerebrospinal fluid of patients at time of a first attack is associated with a subsequent diagnosis of MS and a higher relapse rate...
January 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28055077/risk-of-multiple-sclerosis-after-a-clinically-isolated-syndrome-from-magnetic-resonance-imaging-to-oligoclonal-bands-to-activated-t-cells
#7
Jeffrey M Gelfand
No abstract text is available yet for this article.
January 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28055076/looking-toward-the-future-with-you
#8
S Andrew Josephson
No abstract text is available yet for this article.
January 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28055074/surgical-treatment-of-nonlesional-neocortical-epilepsy-long-term-longitudinal-study
#9
Dong Wook Kim, Sang Kun Lee, Hye-Jin Moon, Ki-Young Jung, Kon Chu, Chun-Ki Chung
Importance: The proportion of surgery for nonlesional neocortical epilepsy has recently increased, with a decrease in surgery for mesial temporal lobe epilepsy. However, there are only a few studies regarding the long-term surgical outcome and the potential prognostic factors for patients with nonlesional neocortical epilepsy. Objective: To evaluate the long-term surgical outcome and to identify possible prognostic factors in patients with nonlesional neocortical epilepsy...
January 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28055073/imaging-as-the-nidus-of-precision-cerebrovascular-health-a-million-brains-initiative
#10
David S Liebeskind, Konark Malhotra, Jason D Hinman
No abstract text is available yet for this article.
January 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28055071/improved-muscular-weakness-during-asthma-exacerbation
#11
Stephanie Delstanche, Laurent Servais, Teresa Gidaro
No abstract text is available yet for this article.
January 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28027343/recommendations-for-the-treatment-of-patients-with-parkinson-disease-during-ramadan
#12
Philippe Damier, Jasem Al-Hashel
Importance: Every year, Ramadan fasting is practiced by many Muslim individuals. In cases of chronic disease, religious texts allow fasting to be broken. However, many believers still want to fast even at the risk of damaging their health. To our knowledge, there are no published recommendations on the medical management of Parkinson disease (PD) during Ramadan. Effective treatments exist in PD and usually require several daily drug intakes. Apart from worsening symptoms, interrupting PD treatment might lead to a severe withdrawal syndrome...
December 27, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/28027337/association-of-albumin-levels-with-outcome-in-intravenous-immunoglobulin-treated-guillain-barr%C3%A3-syndrome
#13
Willem-Jan R Fokkink, Christa Walgaard, Krista Kuitwaard, Anne P Tio-Gillen, Pieter A van Doorn, Bart C Jacobs
Importance: There is an urgent need for biomarkers to monitor treatment efficacy and anticipate outcome in patients with Guillain-Barré syndrome (GBS). Objective: To assess whether there is an association between serum albumin levels, a widely used and relatively easily measurable biomarker of health and inflammation, and the clinical course and outcome of GBS in patients treated with intravenous immunoglobulin (IVIG). Design, Setting, and Participants: We used serum samples derived from a cohort of patients with GBS admitted to hospitals across the Netherlands participating in national GBS studies from May 5, 1986, through August 2, 2000...
December 27, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/28027332/opicapone-as-adjunct-to-levodopa-therapy-in-patients-with-parkinson-disease-and-motor-fluctuations-a-randomized-clinical-trial
#14
Andrew J Lees, Joaquim Ferreira, Olivier Rascol, Werner Poewe, José-Francisco Rocha, Michelle McCrory, Patricio Soares-da-Silva
Importance: Catechol O-methyltransferase (COMT) inhibitors are an established treatment for end-of-dose motor fluctuations associated with levodopa therapy in patients with Parkinson disease (PD). Current COMT inhibitors carry a high risk for toxic effects to hepatic cells or show moderate improvement. Opicapone was designed to be effective without the adverse effects. Objective: To evaluate the efficacy and safety of 25- and 50-mg/d dosages of opicapone compared with placebo as adjunct to levodopa therapy in patients with PD experiencing end-of-dose motor fluctuations...
December 27, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/28027331/is-serum-albumin-associated-with-guillain-barr%C3%A3-syndrome-outcomes
#15
Richard A C Hughes
No abstract text is available yet for this article.
December 27, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/28027328/opicapone-a-novel-adjunct-for-an-old-standard
#16
Allison Boyle, Jessika Suescun, Mya C Schiess
No abstract text is available yet for this article.
December 27, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27992635/top-of-the-basilar-syndrome-presenting-with-convulsions
#17
William L Conte, Chandler E Gill, Jose Biller
No abstract text is available yet for this article.
December 19, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27992633/personality-changes-executive-dysfunction-and-motor-and-memory-impairment
#18
Alfonso Sebastian López Chiriboga, Takuya Konno, Jay A van Gerpen
No abstract text is available yet for this article.
December 19, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27992632/interpreting-periodic-and-rhythmic-electroencephalographic-patterns-in-critically-ill-patients
#19
Sonia Krish, Carl W Bazil
No abstract text is available yet for this article.
December 19, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27992627/associations-between-%C3%AE-amyloid-kinetics-and-the-%C3%AE-amyloid-diurnal-pattern-in-the-central-nervous-system
#20
Brendan P Lucey, Kwasi G Mawuenyega, Bruce W Patterson, Donald L Elbert, Vitaliy Ovod, Tom Kasten, John C Morris, Randall J Bateman
Importance: Recent studies found that the concentration of amyloid-β (Aβ) fluctuates with the sleep-wake cycle. Although the amplitude of this day/night pattern attenuates with age and amyloid deposition, to our knowledge, the association of Aβ kinetics (ie, production, turnover, and clearance) with this oscillation has not been studied. Objective: To determine the association between Aβ kinetics, age, amyloid levels, and the Aβ day/night pattern in humans...
December 19, 2016: JAMA Neurology
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