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JAMA Neurology

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https://www.readbyqxmd.com/read/29204661/informing-vs-changing-the-practice-of-carotid-revascularization
#1
James F Meschia
No abstract text is available yet for this article.
December 4, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29204653/national-patterns-of-carotid-revascularization-before-and-after-the-carotid-revascularization-endarterectomy-vs-stenting-trial-crest
#2
Fadar Oliver Otite, Priyank Khandelwal, Amer M Malik, Seemant Chaturvedi
Importance: The Carotid Revascularization Endarterectomy vs Stenting Trial (CREST) showed greater safety of carotid artery stenting (CAS) in patients younger than 70 years and carotid endarterectomy (CEA) in those older than 70 years. It is unknown how the result of CREST has influenced carotid revascularization choices in the United States. Objective: To evaluate national patterns in CAS performance in patients older than 70 years in the post-CREST (2011-2014) compared with the pre-CREST (2007-2010) era...
December 4, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29204605/association-between-microinfarcts-and-blood-pressure-trajectories
#3
Jonathan Graff-Radford, Mekala R Raman, Alejandro A Rabinstein, Scott A Przybelski, Timothy G Lesnick, Bradley F Boeve, Melissa E Murray, Dennis W Dickson, R Ross Reichard, Joseph E Parisi, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci
Importance: Cerebral microinfarcts are associated with increased risk of cognitive impairment and may have different risk factors than macroinfarcts. Subcortical microinfarcts are associated with declining blood pressure (BP) in elderly individuals. Objective: To investigate BP slopes as a risk factor for microinfarcts. Design, Setting, and Participants: From the population-based Mayo Clinic Study of Aging, 303 of 1158 individuals (26.2%) in this cohort study agreed to have an autopsy between November 1, 2004, and March 31, 2016...
December 4, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29204600/further-actions-are-needed-to-prevent-maternal-deaths-from-epilepsy
#4
Stephen J McCall, Bryn Kemp, Marian Knight
No abstract text is available yet for this article.
December 4, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29197216/early-cognitive-structural-and-microstructural-changes-in-presymptomatic-c9orf72-carriers-younger-than-40-years
#5
Anne Bertrand, Junhao Wen, Daisy Rinaldi, Marion Houot, Sabrina Sayah, Agnès Camuzat, Clémence Fournier, Sabrina Fontanella, Alexandre Routier, Philippe Couratier, Florence Pasquier, Marie-Odile Habert, Didier Hannequin, Olivier Martinaud, Paola Caroppo, Richard Levy, Bruno Dubois, Alexis Brice, Stanley Durrleman, Olivier Colliot, Isabelle Le Ber
Importance: Presymptomatic carriers of chromosome 9 open reading frame 72 (C9orf72) mutation, the most frequent genetic cause of frontotemporal lobar degeneration and amyotrophic lateral sclerosis, represent the optimal target population for the development of disease-modifying drugs. Preclinical biomarkers are needed to monitor the effect of therapeutic interventions in this population. Objectives: To assess the occurrence of cognitive, structural, and microstructural changes in presymptomatic C9orf72 carriers...
December 2, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29181534/association-between-decline-in-slow-vital-capacity-and-respiratory-insufficiency-use-of-assisted-ventilation-tracheostomy-or-death-in-patients-with-amyotrophic-lateral-sclerosis
#6
Jinsy A Andrews, Lisa Meng, Sarah F Kulke, Stacy A Rudnicki, Andrew A Wolff, Michael E Bozik, Fady I Malik, Jeremy M Shefner
Importance: The prognostic value of slow vital capacity (SVC) in relation to respiratory function decline and disease progression in patients with amyotrophic lateral sclerosis (ALS) is not well understood. Objective: To investigate the rate of decline in percentage predicted SVC and its association with respiratory-related clinical events and mortality in patients with ALS. Design, Setting, and Participants: This retrospective study included 893 placebo-treated patients from 2 large clinical trials (EMPOWER and BENEFIT-ALS, conducted from March 28, 2011, to November 1, 2012, and from October 23, 2012, to March 21, 2014, respectively) and an ALS trial database (PRO-ACT, containing studies completed between 1990 and 2010) to investigate the rate of decline in SVC...
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29181526/cortical-structures-associated-with-human-blood-pressure-control
#7
Nuria Lacuey, Johnson P Hampson, Wanchat Theeranaew, Bilal Zonjy, Ajay Vithala, Norma J Hupp, Kenneth A Loparo, Jonathan P Miller, Samden D Lhatoo
Importance: A better understanding of the role of cortical structures in blood pressure control may help us understand cardiovascular collapse that may lead to sudden unexpected death in epilepsy (SUDEP). Objective: To identify cortical control sites for human blood pressure regulation. Design, Setting, and Participants: Patients with intractable epilepsy undergoing intracranial electrode implantation as a prelude to epilepsy surgery in the Epilepsy Monitoring Unit at University Hospitals Cleveland Medical Center were potential candidates for this study...
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29181513/sensitivity-to-the-deficits-associated-with-traumatic-brain-injury-or-chronic-traumatic-encephalopathy-reply
#8
Amanda R Rabinowitz, Sameer K Deshpande, Dylan S Small
No abstract text is available yet for this article.
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29181510/neurologic-phenotypes-associated-with-mutations-in-rtn4ip1-opa10-in-children-and-young-adults
#9
Majida Charif, Alessia Nasca, Kyle Thompson, Sylvie Gerber, Christine Makowski, Neda Mazaheri, Céline Bris, David Goudenège, Andrea Legati, Reza Marrofian, Gholamreza Shariati, Eleonora Lamantea, Sila Hopton, Anna Ardissone, Isabella Moroni, Melania Giannotta, Corinna Siegel, Tim M Strom, Holger Prokisch, Catherine Vignal-Clermont, Sabine Derrien, Xavier Zanlonghi, Josseline Kaplan, Christian P Hamel, Stephanie Leruez, Vincent Procaccio, Dominique Bonneau, Pascal Reynier, Frances E White, Steven A Hardy, Inês A Barbosa, Michael A Simpson, Roshni Vara, Yaumara Perdomo Trujillo, Hamind Galehdari, Charu Deshpande, Tobias B Haack, Jean-Michel Rozet, Robert W Taylor, Daniele Ghezzi, Patrizia Amati-Bonneau, Guy Lenaers
Importance: Neurologic disorders with isolated symptoms or complex syndromes are relatively frequent among mitochondrial inherited diseases. Recessive RTN4IP1 gene mutations have been shown to cause isolated and syndromic optic neuropathies. Objective: To define the spectrum of clinical phenotypes associated with mutations in RTN4IP1 encoding a mitochondrial quinone oxidoreductase. Design, Setting, and Participants: This study involved 12 individuals from 11 families with severe central nervous system diseases and optic atrophy...
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29181506/sensitivity-to-the-deficits-associated-with-traumatic-brain-injury-or-chronic-traumatic-encephalopathy
#10
Michael Hoffmann
No abstract text is available yet for this article.
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29181505/rethinking-eligibility-for-experimental-clinical-trials
#11
Lauren Gibbs
No abstract text is available yet for this article.
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159415/omitted-funding-information
#12
(no author information available yet)
No abstract text is available yet for this article.
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159412/leaving-tiny-unruptured-intracranial-aneurysms-untreated-why-is-it-so-hard
#13
S Claiborne Johnston
No abstract text is available yet for this article.
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159408/public-health-interventions-for-decreasing-dementia-risk
#14
Graeme J Hankey
No abstract text is available yet for this article.
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159405/management-of-tiny-unruptured-intracranial-aneurysms-a-comparative-effectiveness-analysis
#15
Ajay Malhotra, Xiao Wu, Howard P Forman, Charles C Matouk, Dheeraj Gandhi, Pina Sanelli
Importance: Unruptured intracranial aneurysms (UIAs) are relatively common in the general population and are being increasingly diagnosed; a significant proportion are tiny (≤3 mm) aneurysms. There is significant heterogeneity in practice and lack of clear guidelines on the management of incidental, tiny UIAs. It is important to quantify the implications of different management strategies in terms of health benefits to patients. Objective: To evaluate the effectiveness of routine treatment (aneurysm coiling) vs 3 strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny UIAs...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159397/extracellular-mitochondria-for-therapy-and-diagnosis-in-acute-central-nervous-system-injury
#16
Kazuhide Hayakawa, Morgan Bruzzese, Sherry H-Y Chou, MingMing Ning, Xunming Ji, Eng H Lo
Objective: Acute central nervous system (CNS) injury after stroke and trauma remains a clinical challenge with limited diagnostic and therapeutic approaches. In this article, we review studies suggesting that after CNS injury, mitochondria can be released into extracellular space as a "help-me" signal to augment recovery. Results are taken from experimental studies in cell and animal models and an initial proof-of-concept analysis in humans suggesting the functional relevance of extracellular mitochondria after acute CNS injury...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159396/association-of-nonalcoholic-fatty-liver-disease-with-lower-brain-volume-in-healthy-middle-aged-adults-in-the-framingham-study
#17
Galit Weinstein, Shira Zelber-Sagi, Sarah R Preis, Alexa S Beiser, Charles DeCarli, Elizabeth K Speliotes, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri
Importance: Nonalcoholic fatty liver disease (NAFLD) is a common condition that is most often asymptomatic. It is associated with metabolic syndrome, incident diabetes, carotid atherosclerosis, and endothelial dysfunction, conditions that in turn are strongly linked with brain damage and cognitive impairment. However, it is not known whether NAFLD is associated with structural brain measures in humans. Objective: To assess the association between prevalent NAFLD and brain magnetic resonance imaging (MRI) measures...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159373/bortezomib-for-neuromyelitis-optica-spectrum-disorder-a-new-therapeutic-option-for-the-more-severe-forms
#18
Jennifer Taylor, Sarosh R Irani
No abstract text is available yet for this article.
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159372/bortezomib-for-neuromyelitis-optica-spectrum-disorder-a-new-therapeutic-option-for-the-more-severe-forms
#19
Su-Hyun Kim
No abstract text is available yet for this article.
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159366/bortezomib-for-neuromyelitis-optica-spectrum-disorder-a-new-therapeutic-option-for-the-more-severe-forms-reply
#20
Chao Zhang, Fu-Dong Shi
No abstract text is available yet for this article.
November 20, 2017: JAMA Neurology
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