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JAMA Neurology

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https://www.readbyqxmd.com/read/29710225/prevalence-and-outcomes-of-amyloid-positivity-among-persons-without-dementia-in-a-longitudinal-population-based-setting
#1
Rosebud O Roberts, Jeremiah A Aakre, Walter K Kremers, Maria Vassilaki, David S Knopman, Michelle M Mielke, Rabe Alhurani, Yonas E Geda, Mary M Machulda, Preciosa Coloma, Barbara Schauble, Val J Lowe, Clifford R Jack, Ronald C Petersen
Importance: Brain amyloid deposition is a marker of Alzheimer disease (AD) pathology. The population-based prevalence and outcomes of amyloid positivity in a population without dementia are important for understanding the trajectory of amyloid positivity to clinically significant outcomes and for designing AD prevention trials. Objective: To determine prevalence and outcomes of amyloid positivity in a population without dementia. Design, Setting, and Participants: In the prospective, population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota, participants without dementia were randomly selected from the county population and were clinically and cognitively evaluated at baseline and every 15 months from August 1, 2008, to September 18, 2018...
April 30, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710218/fertility-and-birth-outcomes-in-women-with-epilepsy-seeking-pregnancy
#2
Page B Pennell, Jacqueline A French, Cynthia L Harden, Anne Davis, Emilia Bagiella, Evie Andreopoulos, Connie Lau, Nichelle Llewellyn, Sarah Barnard, Stephanie Allien
Importance: Prior studies report lower birth rates for women with epilepsy (WWE) but have been unable to differentiate between biological and social contributions. To our knowledge, we do not have data to inform WWE seeking pregnancy if their likelihood of achieving pregnancy is biologically reduced compared with their peers. Objective: To determine if WWE without a prior diagnosis of infertility or related disorders are as likely to achieve pregnancy within 12 months as their peers without epilepsy...
April 30, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710120/a-histologic-study-of-the-circadian-system-in-parkinson-disease-multiple-system-atrophy-and-progressive-supranuclear-palsy
#3
Eduardo De Pablo-Fernández, Robert Courtney, Thomas T Warner, Janice L Holton
Importance: Circadian dysfunction may be associated with the symptoms and neurodegeneration in Parkinson disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP), although the underlying neuroanatomical site of disruption and pathophysiological mechanisms are not fully understood. Objective: To perform a neuropathological analysis of disease-specific inclusions in the key structures of the circadian system in patients with PD, MSA, and PSP...
April 30, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710083/publication-and-dissemination-of-results-in-clinical-trials-of-neurology
#4
Anirudh Sreekrishnan, David Mampre, Cora Ormseth, Laura Miyares, Audrey Leasure, Joseph S Ross, Kevin N Sheth
No abstract text is available yet for this article.
April 30, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710213/novel-glial-targets-and-recurrent-longitudinally-extensive-transverse-myelitis
#5
Jiraporn Jitprapaikulsan, A Sebastian Lopez Chiriboga, Eoin P Flanagan, James P Fryer, Andrew McKeon, Brian G Weinshenker, Sean J Pittock
No abstract text is available yet for this article.
April 27, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710331/anti-tumor-necrosis-factor-therapy-and-incidence-of-parkinson-disease-among-patients-with-inflammatory-bowel-disease
#6
Inga Peter, Marla Dubinsky, Susan Bressman, Andrew Park, Changyue Lu, Naijun Chen, Anthony Wang
Importance: Despite established genetic and pathophysiologic links between inflammatory bowel disease (IBD) and Parkinson disease (PD), clinical data supporting this association remain scarce. Although systemic inflammation is considered a potential biological mechanism shared between the 2 diseases, the role of reduced systemic inflammation through IBD-directed anti-tumor necrosis factor (anti-TNF) therapy in PD risk is largely unknown. Objective: To compare the incidence of PD among individuals with or without IBD and to assess whether PD risk among patients with IBD is altered by anti-TNF therapy...
April 23, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710293/use-of-vitamins-and-dietary-supplements-by-patients-with-multiple-sclerosis-a-review
#7
Emily Evans, Laura Piccio, Anne H Cross
Importance: Surveys of patients with multiple sclerosis report that most are interested in modifying their diet and using supplements to potentially reduce the severity and symptoms of the disease. This review provides an updated overview of the current state of evidence for the role that vitamins and dietary supplements play in multiple sclerosis and its animal models, with an emphasis on recent studies, and addresses biological plausibility and safety issues. Observations: Several vitamins and dietary supplements have been recently explored both in animal models and by patients with multiple sclerosis...
April 23, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710269/association-of-sickle-cell-trait-with-ischemic-stroke-among-african-americans-a-meta-analysis
#8
Hyacinth I Hyacinth, Cara L Carty, Samantha R Seals, Marguerite R Irvin, Rakhi P Naik, Gregory L Burke, Neil A Zakai, James G Wilson, Nora Franceschini, Cheryl A Winkler, Victor A David, Jeffrey B Kopp, Suzanne E Judd, Robert J Adams, W T Longstreth, Leonard Egede, Daniel T Lackland, Herman Taylor, JoAnn E Manson, Virginia Howard, Matthew Allison, Beatrice E Gee, Adolfo Correa, Monika M Safford, Donna K Arnett, George Howard, Alexander P Reiner, Mary Cushman
Importance: African Americans and individuals of African ancestry have a higher risk of stroke compared with non-Hispanic white individuals. Identifying the source of this disparity could provide an opportunity for clinical stroke risk stratification and more targeted therapy. Whether sickle cell trait (SCT) is an indicator of increased risk of ischemic stroke among African Americans is still unclear. Objective: To examine whether SCT is associated with a higher risk of incident ischemic stroke among African Americans...
April 23, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710250/controversies-and-future-directions-of-ocular-biomarkers-in-alzheimer-disease
#9
Sally S Ong, P Murali Doraiswamy, Eleonora M Lad
No abstract text is available yet for this article.
April 23, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710184/discovering-new-benefits-from-old-drugs-with-big-data-promise-for-parkinson-disease
#10
Abby L Olsen, Trond Riise, Clemens R Scherzer
No abstract text is available yet for this article.
April 23, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710121/association-of-retinal-ganglion-cell-layer-thickness-with-future-disease-activity-in-patients-with-clinically-isolated-syndrome
#11
Hanna G Zimmermann, Benjamin Knier, Timm Oberwahrenbrock, Janina Behrens, Catherina Pfuhl, Lilian Aly, Miriam Kaminski, Muna-Miriam Hoshi, Svenja Specovius, René M Giess, Michael Scheel, Mark Mühlau, Judith Bellmann-Strobl, Klemens Ruprecht, Bernhard Hemmer, Thomas Korn, Friedemann Paul, Alexander U Brandt
Importance: Clinically isolated syndrome (CIS) describes a first clinical incident suggestive of multiple sclerosis (MS). Identifying patients with CIS who have a high risk of future disease activity and subsequent MS diagnosis is crucial for patient monitoring and the initiation of disease-modifying therapy. Objective: To investigate the association of retinal optical coherence tomography (OCT) results with future disease activity in patients with CIS. Design, Setting, and Participants: This prospective, longitudinal cohort study took place between January 2011 and May 2017 at 2 German tertiary referral centers...
April 23, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710329/chronic-meningitis-investigated-via-metagenomic-next-generation-sequencing
#12
Michael R Wilson, Brian D O'Donovan, Jeffrey M Gelfand, Hannah A Sample, Felicia C Chow, John P Betjemann, Maulik P Shah, Megan B Richie, Mark P Gorman, Rula A Hajj-Ali, Leonard H Calabrese, Kelsey C Zorn, Eric D Chow, John E Greenlee, Jonathan H Blum, Gary Green, Lillian M Khan, Debarko Banerji, Charles Langelier, Chloe Bryson-Cahn, Whitney Harrington, Jairam R Lingappa, Niraj M Shanbhag, Ari J Green, Bruce J Brew, Ariane Soldatos, Luke Strnad, Sarah B Doernberg, Cheryl A Jay, Vanja Douglas, S Andrew Josephson, Joseph L DeRisi
Importance: Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhanced, unbiased diagnostic approaches are needed. Objective: To present a case series of patients with diagnostically challenging subacute or chronic meningitis using metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) supported by a statistical framework generated from mNGS of control samples from the environment and from patients who were noninfectious...
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710298/recurrent-ischemic-and-hemorrhagic-strokes-in-a-young-adult
#13
Eva A Rocha, Aneesh B Singhal
No abstract text is available yet for this article.
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710173/preventing-sudden-unexpected-death-in-epilepsy
#14
Orrin Devinsky, Philippe Ryvlin, Daniel Friedman
No abstract text is available yet for this article.
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710119/cerebral-microbleeds-and-the-effect-of-intensive-blood-pressure-reduction-on-hematoma-expansion-and-functional-outcomes-a-secondary-analysis-of-the-atach-2-randomized-clinical-trial
#15
Ashkan Shoamanesh, Andrea Morotti, Javier M Romero, Jamary Oliveira-Filho, Frieder Schlunk, Michael J Jessel, Alison M Ayres, Anastasia Vashkevich, Kristin Schwab, Mohammad R Afzal, Christy Cassarly, Renee H Martin, Adnan I Qureshi, Steven M Greenberg, Jonathan Rosand, Joshua N Goldstein
Importance: Response to intensive blood pressure (BP) lowering in acute intracerebral hemorrhage (ICH) might vary with the degree of underlying cerebral small vessel disease. Objectives: To characterize cerebral microbleeds (CMBs) in acute ICH and to assess the potential for interaction between underlying small vessel disease (as indicated by CMB number and location) and assignment to acute intensive BP targeting for functional outcomes and hematoma expansion. Design, Setting, and Participants: Preplanned subgroup analyses in the Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 (ATACH-2) trial were performed...
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710099/effect-of-pain-neuroscience-education-combined-with-cognition-targeted-motor-control-training-on-chronic-spinal-pain-a-randomized-clinical-trial
#16
Anneleen Malfliet, Jeroen Kregel, Iris Coppieters, Robby De Pauw, Mira Meeus, Nathalie Roussel, Barbara Cagnie, Lieven Danneels, Jo Nijs
Importance: Effective treatments for chronic spinal pain are essential to reduce the related high personal and socioeconomic costs. Objective: To compare pain neuroscience education combined with cognition-targeted motor control training with current best-evidence physiotherapy for reducing pain and improving functionality, gray matter morphologic features, and pain cognitions in individuals with chronic spinal pain. Design, Setting, and Participants: Multicenter randomized clinical trial conducted from January 1, 2014, to January 30, 2017, among 120 patients with chronic nonspecific spinal pain in 2 outpatient hospitals with follow-up at 3, 6, and 12 months...
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29710076/what-s-next-generation-for-the-diagnosis-of-chronic-meningitis
#17
Kenneth L Tyler
No abstract text is available yet for this article.
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29630713/missing-funding-information
#18
(no author information available yet)
No abstract text is available yet for this article.
April 9, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29630712/selective-genetic-overlap-between-amyotrophic-lateral-sclerosis-and-diseases-of-the-frontotemporal-dementia-spectrum
#19
Celeste M Karch, Natalie Wen, Chun C Fan, Jennifer S Yokoyama, Naomi Kouri, Owen A Ross, Gunter Höglinger, Ulrich Müller, Raffaele Ferrari, John Hardy, Gerard D Schellenberg, Patrick M Sleiman, Parastoo Momeni, Christopher P Hess, Bruce L Miller, Manu Sharma, Vivianna Van Deerlin, Olav B Smeland, Ole A Andreassen, Anders M Dale, Rahul S Desikan
Importance: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by loss of upper and lower motor neurons. Although novel ALS genetic variants have been identified, the shared genetic risk between ALS and other neurodegenerative disorders remains poorly understood. Objectives: To examine whether there are common genetic variants that determine the risk for ALS and other neurodegenerative diseases and to identify their functional pathways...
April 9, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29630704/deaths-in-epilepsy-what-we-are-missing
#20
Orrin Devinsky, Anuradha Singh, Daniel Friedman
No abstract text is available yet for this article.
April 9, 2018: JAMA Neurology
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