journal
MENU ▼
Read by QxMD icon Read
search

JAMA Neurology

journal
https://www.readbyqxmd.com/read/27893897/imaging-of-glial-cell-activation-and-white-matter-integrity-in-brains-of-active-and-recently-retired-national-football-league-players
#1
Jennifer M Coughlin, Yuchuan Wang, Il Minn, Nicholas Bienko, Emily B Ambinder, Xin Xu, Matthew E Peters, John W Dougherty, Melin Vranesic, Soo Min Koo, Hye-Hyun Ahn, Merton Lee, Chris Cottrell, Haris I Sair, Akira Sawa, Cynthia A Munro, Christopher J Nowinski, Robert F Dannals, Constantine G Lyketsos, Michael Kassiou, Gwenn Smith, Brian Caffo, Susumu Mori, Tomas R Guilarte, Martin G Pomper
Importance: Microglia, the resident immune cells of the central nervous system, play an important role in the brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent microglial activation, but there has been little study of persistent glial cell activity in brains of athletes with sports-related traumatic brain injury...
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893883/use-of-magnetic-resonance-imaging-to-visualize-leptomeningeal-inflammation-in-patients-with-multiple-sclerosis-a-review
#2
Jonathan Zurawski, Hans Lassmann, Rohit Bakshi
Importance: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system traditionally characterized by an initial relapsing-remitting clinical course and focal inflammatory lesions that have a predilection for the periventricular white matter. Recently, however, histopathologic and imaging studies have illustrated a more complex pathologic substrate involving cortical demyelination, gray matter atrophy, and meningeal inflammation. Neuroimaging advances have facilitated improved detection of cortical pathology, but our understanding of the pathogenesis of cortical disease remains incomplete...
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893877/intra-arterial-treatment-for-basilar-artery-occlusion-reply
#3
Reinier C van Houwelingen, Gert-Jan Luijckx, Maarten Uyttenboogaart
No abstract text is available yet for this article.
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893876/imaging-the-acute-formation-of-a-cortical-microbleed-in-cerebral-amyloid-angiopathy
#4
Gregoire Boulouis, Andreas Charidimou, Susanne Van Veluw, Steven M Greenberg
No abstract text is available yet for this article.
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893875/can-sustained-glia-mediated-brain-inflammation-after-repeated-concussive-brain-injury-be-detected-in-vivo
#5
Kristina G Witcher, Jonathan P Godbout
No abstract text is available yet for this article.
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893874/association-of-perivascular-localization-of-aquaporin-4-with-cognition-and-alzheimer-disease-in-aging-brains
#6
Douglas M Zeppenfeld, Matthew Simon, J Douglas Haswell, Daryl D'Abreo, Charles Murchison, Joseph F Quinn, Marjorie R Grafe, Randall L Woltjer, Jeffrey Kaye, Jeffrey J Iliff
Importance: Cognitive impairment and dementia, including Alzheimer disease (AD), are common within the aging population, yet the factors that render the aging brain vulnerable to these processes are unknown. Perivascular localization of aquaporin-4 (AQP4) facilitates the clearance of interstitial solutes, including amyloid-β, through the brainwide network of perivascular pathways termed the glymphatic system, which may be compromised in the aging brain. Objectives: To determine whether alterations in AQP4 expression or loss of perivascular AQP4 localization are features of the aging human brain and to define their association with AD pathology...
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893873/association-of-cerebrospinal-fluid-ferritin-level-with-preclinical-cognitive-decline-in-apoe-%C3%AE%C2%B54-carriers
#7
Scott Ayton, Noel G Faux, Ashley I Bush
No abstract text is available yet for this article.
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893872/intra-arterial-treatment-for-basilar-artery-occlusion
#8
Alysha Bhatti, Prasanthi Sivakumaran
No abstract text is available yet for this article.
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893017/evaluation-of-cognitive-deficits-and-structural-hippocampal-damage-in-encephalitis-with-leucine-rich-glioma-inactivated-1-antibodies
#9
Carsten Finke, Harald Prüss, Josephine Heine, Sigrid Reuter, Ute A Kopp, Florian Wegner, Florian Then Bergh, Sebastian Koch, Olav Jansen, Thomas Münte, Günther Deuschl, Klemens Ruprecht, Winfried Stöcker, Klaus-Peter Wandinger, Friedemann Paul, Thorsten Bartsch
Importance: Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants of autoimmune encephalitis with antibodies targeting neuronal surface antigens. However, the neuroimaging pattern and long-term cognitive outcome are not well understood. Objective: To study cognitive outcome and structural magnetic resonance imaging (MRI) alterations in patients with anti-LGI1 encephalitis. Design, Setting, and Participants: A cross-sectional study was conducted at the Departments of Neurology at Charité-Universitätsmedizin Berlin and University Hospital Schleswig-Holstein, Kiel, Germany...
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893014/durability-of-the-rituximab-response-in-acetylcholine-receptor-autoantibody-positive-myasthenia-gravis
#10
Kimberly R Robeson, Aditya Kumar, Benison Keung, Daniel B DiCapua, Emily Grodinsky, Huned S Patwa, Panos A Stathopoulos, Jonathan M Goldstein, Kevin C O'Connor, Richard J Nowak
Importance: Myasthenia gravis (MG), an autoimmune disorder of neuromuscular transmission, is treated by an array of immunotherapeutics, many of which are nonspecific. Even with current therapies, a subset of patients has medically refractory MG. The benefits of B-cell-targeted therapy with rituximab have been observed in MG; however, the duration of these benefits after treatment is unclear. Objective: To evaluate the durability of response to rituximab in the treatment of acetylcholine receptor autoantibody-positive (AChR+) generalized MG...
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893010/rethinking-outcomes-in-leucine-rich-glioma-inactivated-1-protein-encephalitis-good-isn-t-good-enough
#11
Gregory S Day
No abstract text is available yet for this article.
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893008/use-of-genetic-testing-in-amyotrophic-lateral-sclerosis-by-neurologists
#12
Karissa C Arthur, Carly Doyle, Adriano Chiò, Bryan J Traynor
No abstract text is available yet for this article.
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27892983/association-of-mutations-in-tbk1-with-sporadic-and-familial-amyotrophic-lateral-sclerosis-and-frontotemporal-dementia
#13
Axel Freischmidt, Kathrin Müller, Albert C Ludolph, Jochen H Weishaupt, Peter M Andersen
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related neurodegenerative syndromes that occur sporadically or have been associated with mostly dominant inheritance of mutations in more than 30 genes. A critical issue is whether all reported mutations are disease causing or are coincidental findings. In this review we analyze the pathogenicity of nonsynonymous variants in the newly discovered gene encoding TANK-binding kinase 1 (TBK1). The available data suggest that mutations in TBK1 that cause a 50% reduction of TBK1 protein levels are pathogenic...
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27892981/rituximab-in-treatment-refractory-myasthenia-gravis
#14
Nicholas J Silvestri, Gil I Wolfe
No abstract text is available yet for this article.
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27842190/a-63-year-old-man-with-progressive-visual-symptoms
#15
Sara B Mitchell, Diane Lucente, Mykol Larvie, M I Cobos, Matthew Frosch, Bradford C Dickerson
A 63-year-old man presented with a 4-year history of insidious onset and gradual progression of visual symptoms including right homonymous hemianopsia, alexia, and simultanagnosia with preserved memory. Magnetic resonance imaging, perfusion single-photon emission computed tomography, and fluorodeoxyglucose positron emission tomographic scans revealed strikingly asymmetric left parieto-occipital abnormality. Neuropsychological testing was performed. The differential diagnosis, pathologic findings, genetic testing results, and diagnosis are discussed...
November 14, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27842176/female-and-male-specific-risk-factors-for-stroke-a-systematic-review-and-meta-analysis
#16
Michiel H F Poorthuis, Annemijn M Algra, Ale Algra, L Jaap Kappelle, Catharina J M Klijn
Importance: The incidence of stroke is higher in men than in women. The influence of sex-specific risk factors on stroke incidence and mortality is largely unknown. Objective: To conduct a systematic review and meta-analysis of female- and male-specific risk factors for stroke. Data Sources: PubMed, EMBASE, and the bibliographies of articles were searched for studies published between January 1, 1985, and January 26, 2015, reporting on the association between female- and male-specific characteristics and stroke...
November 14, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27842175/association-of-amyloid-pathology-with-myelin-alteration-in-preclinical-alzheimer-disease
#17
Douglas C Dean, Samuel A Hurley, Steven R Kecskemeti, J Patrick O'Grady, Cristybelle Canda, Nancy J Davenport-Sis, Cynthia M Carlsson, Henrik Zetterberg, Kaj Blennow, Sanjay Asthana, Mark A Sager, Sterling C Johnson, Andrew L Alexander, Barbara B Bendlin
Importance: The accumulation of aggregated β-amyloid and tau proteins into plaques and tangles is a central feature of Alzheimer disease (AD). While plaque and tangle accumulation likely contributes to neuron and synapse loss, disease-related changes to oligodendrocytes and myelin are also suspected of playing a role in development of AD dementia. Still, to our knowledge, little is known about AD-related myelin changes, and even when present, they are often regarded as secondary to concomitant arteriosclerosis or related to aging...
November 14, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27842174/association-of-cardiovascular-risk-factors-and-stroke-with-alzheimer-disease-reply
#18
Giuseppe Tosto, Richard Mayeux
No abstract text is available yet for this article.
November 14, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27842173/association-of-brain-amyloid-%C3%AE-with-slow-gait-in-elderly-individuals-without-dementia-influence-of-cognition-and-apolipoprotein-e-%C3%AE%C2%B54-genotype
#19
Neelesh K Nadkarni, Subashan Perera, Beth E Snitz, Chester A Mathis, Julie Price, Jeff D Williamson, Steven T DeKosky, William E Klunk, Oscar L Lopez
Importance: Motor slowing appears in preclinical Alzheimer disease (AD), progresses with AD progression, and is associated with AD pathologic findings at autopsy. Whether amyloid-β (Aβ) is associated with gait speed in elderly individuals without dementia and whether cognition and apolipoprotein E ε4 (APOE ε4) influence this association remain unknown. Objectives: To examine the association between Aβ and gait speed in elderly individuals without dementia and to study the influence of cognition and APOE ε4 status on this association...
November 14, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27842151/association-of-cardiovascular-risk-factors-and-stroke-with-alzheimer-disease
#20
Priyanka Sivakumaran
No abstract text is available yet for this article.
November 14, 2016: JAMA Neurology
journal
journal
44129
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"