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JAMA Neurology

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https://www.readbyqxmd.com/read/28319244/congenital-zika-virus-infection-beyond-neonatal-microcephaly-reply
#1
Adriana Suely de Oliveira Melo, Leila Chimelli, Amilcar Tanuri
No abstract text is available yet for this article.
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319243/association-of-antioxidant-supplement-use-and-dementia-in-the-prevention-of-alzheimer-s-disease-by-vitamin-e-and-selenium-trial-preadvise
#2
Richard J Kryscio, Erin L Abner, Allison Caban-Holt, Mark Lovell, Phyllis Goodman, Amy K Darke, Monica Yee, John Crowley, Frederick A Schmitt
Importance: Oxidative stress is an established dementia pathway, but it is unknown if the use of antioxidant supplements can prevent dementia. Objective: To determine if antioxidant supplements (vitamin E or selenium) used alone or in combination can prevent dementia in asymptomatic older men. Design, Setting, and Participants: The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADViSE) trial began as a double-blind randomized clinical trial in May 2002, which transformed into a cohort study from September 2009 to May 2015...
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319241/alzheimer-disease-signature-neurodegeneration-and-apoe-genotype-in-mild-cognitive-impairment-with-suspected-non-alzheimer-disease-pathophysiology
#3
Stefanie Schreiber, Frank Schreiber, Samuel N Lockhart, Andy Horng, Alexandre Bejanin, Susan M Landau, William J Jagust
Importance: There are conflicting results claiming that Alzheimer disease signature neurodegeneration may be more, less, or similarly advanced in individuals with β-amyloid peptide (Aβ)-negative (Aβ-) suspected non-Alzheimer disease pathophysiology (SNAP) than in Aβ-positive (Aβ+) counterparts. Objective: To examine patterns of neurodegeneration in individuals with SNAP compared with their Aβ+ counterparts. Design, Setting, and Participants: A longitudinal cohort study was conducted among individuals with mild cognitive impairment (MCI) and cognitively normal individuals receiving care at Alzheimer's Disease Neuroimaging Initiative sites in the United States and Canada for a mean follow-up period of 30...
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319240/two-paradigms-for-endovascular-thrombectomy-after-intravenous-thrombolysis-for-acute-ischemic-stroke
#4
Gaspard Gerschenfeld, Ioan-Paul Muresan, Raphael Blanc, Michael Obadia, Marie Abrivard, Michel Piotin, Sonia Alamowitch
Importance: Intravenous thrombolysis (IVT) followed by mechanical thrombectomy (MT) is recommended to treat acute ischemic stroke (AIS) with a large vessel occlusion (LVO). Most hospitals do not have on-site MT facilities, and most patients need to be transferred secondarily after IVT (drip and ship), which may have an effect on the neurologic outcome. Objective: To compare the functional independence at 3 months between patients treated under the drip-and-ship paradigm and those treated on site (mothership)...
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319237/congenital-zika-virus-infection-beyond-neonatal-microcephaly
#5
Marcio Leyser, Osvaldo J M Nascimento
No abstract text is available yet for this article.
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319236/preventing-dementia-many-issues-and-not-enough-time
#6
Steven T DeKosky, Lon S Schneider
No abstract text is available yet for this article.
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319234/primary-stroke-centers-vs-comprehensive-stroke-centers-with-interventional-capabilities-which-is-better-for-a-patient-with-suspected-stroke
#7
Louis R Caplan
No abstract text is available yet for this article.
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319232/action-tremor-impaired-balance-and-executive-dysfunction-in-midlife
#8
Rachael Cherie Birch, Julian Norman Trollor
No abstract text is available yet for this article.
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288266/circulating-interleukin-6-in-parkinson-disease
#9
Gustav Nilsonne, Mats Lekander
No abstract text is available yet for this article.
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288265/circulating-interleukin-6-in-parkinson-disease-reply
#10
Xiao-Yan Qin, Yong Cheng
No abstract text is available yet for this article.
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288263/neurofibrillary-tangle-stage-and-the-rate-of-progression-of-alzheimer-symptoms-modeling-using-an-autopsy-cohort-and-application-to-clinical-trial-design
#11
Jing Qian, Bradley T Hyman, Rebecca A Betensky
Importance: The heterogeneity of rate of clinical progression among patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminishes the power of clinical trials using disease-modifying agents. Objective: To gain a better understanding of the factors that affect the natural history of progression in Alzheimer disease for the purpose of improving both clinical care and clinical trial design. Design, Setting, and Participants: A longitudinal cohort study of aging from 2005 to 2014 in the National Alzheimer Coordinating Center...
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288262/aggregation-of-%C3%AE-synuclein-in-the-gonadal-tissue-of-2-patients-with-parkinson-disease
#12
Alicia Garrido, Iban Aldecoa, Ellen Gelpi, Eduardo Tolosa
No abstract text is available yet for this article.
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288261/antioxidant-capacity-and-superoxide-dismutase-activity-in-adrenoleukodystrophy
#13
Bela R Turk, Benjamin E Theisen, Christina L Nemeth, Joel S Marx, Xiaohai Shi, Melissa Rosen, Richard O Jones, Ann B Moser, Paul A Watkins, Gerald V Raymond, Carol Tiffany, Ali Fatemi
Importance: X-linked adrenoleukodystrophy (ALD) may switch phenotype to the fatal cerebral form (ie, cerebral ALD [cALD]), the cause of which is unknown. Determining differences in antioxidant capacity and superoxide dismutase (SOD) levels between phenotypes may allow for the generation of a clinical biomarker for predicting the onset of cALD, as well as initiating a more timely lifesaving therapy. Objective: To identify variations in the levels of antioxidant capacity and SOD activity between ALD phenotypes in patients with cALD or adrenomyeloneuropathy (AMN), heterozygote female carriers, and healthy controls and, in addition, correlate antioxidant levels with clinical outcome scores to determine a possible predictive value...
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288252/the-mystery-of-the-locking-eye
#14
Marc A Bouffard, Nurhan Torun
No abstract text is available yet for this article.
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288247/incorrect-data-used-in-statistical-analyses
#15
Stuart A Batterman, Eva L Feldman
No abstract text is available yet for this article.
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28288243/errors-in-statistical-analyses
#16
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28264097/the-catch-22-of-neuroimaging-disorders-of-consciousness-and-end-of-life-decisions
#17
Emanuel Cabral, Judy Illes
No abstract text is available yet for this article.
March 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28264096/diagnostic-and-prognostic-biomarkers-in-amyotrophic-lateral-sclerosis-neurofilament-light-chain-levels-in-definite-subtypes-of-disease
#18
Alessandra Gaiani, Ilaria Martinelli, Luca Bello, Giorgia Querin, Marco Puthenparampil, Susanna Ruggero, Elisabetta Toffanin, Annachiara Cagnin, Chiara Briani, Elena Pegoraro, Gianni Sorarù
Importance: A clearer definition of the role of neurofilament light chain (NFL) as a biomarker in amyotrophic lateral sclerosis (ALS) is needed. Objectives: To assess the ability of NFL to serve as a diagnostic biomarker in ALS and the prognostic value of cerebrospinal fluid NFL in patients with ALS. Design, Setting, and Participants: In this single-center, retrospective, longitudinal study, disease progression was assessed by the ALS Functional Rating Score-Revised and the ALS Milano-Torino Staging system at baseline and 6, 12, 24, and 36 months...
March 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28264095/association-between-migraine-and-cervical-artery-dissection-the-italian-project-on-stroke-in-young-adults
#19
Valeria De Giuli, Mario Grassi, Corrado Lodigiani, Rosalba Patella, Marialuisa Zedde, Carlo Gandolfo, Andrea Zini, Maria Luisa DeLodovici, Maurizio Paciaroni, Massimo Del Sette, Cristiano Azzini, Antonella Toriello, Rossella Musolino, Rocco Salvatore Calabrò, Paolo Bovi, Maria Sessa, Alessandro Adami, Giorgio Silvestrelli, Anna Cavallini, Simona Marcheselli, Domenico Marco Bonifati, Nicoletta Checcarelli, Lucia Tancredi, Alberto Chiti, Enrico Maria Lotti, Elisabetta Del Zotto, Giampaolo Tomelleri, Alessandra Spalloni, Elisa Giorli, Paolo Costa, Loris Poli, Andrea Morotti, Filomena Caria, Alessia Lanari, Giacomo Giacalone, Paola Ferrazzi, Alessia Giossi, Valeria Piras, Davide Massucco, Cataldo D'Amore, Filomena Di Lisi, Ilaria Casetta, Laura Cucurachi, Masina Cotroneo, Alessandro De Vito, Elisa Coloberti, Maurizia Rasura, Anna Maria Simone, Massimo Gamba, Paolo Cerrato, Giuseppe Micieli, Giovanni Malferrari, Maurizio Melis, Licia Iacoviello, Alessandro Padovani, Alessandro Pezzini
Importance: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). Objective: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD...
March 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28264087/precipitous-deterioration-of-motor-function-cognition-and-behavior
#20
Mireya Fernández-Fournier, David C Perry, Maria Carmela Tartaglia, Mary de May, Adam Boxer, Giovanni Coppola, Chadwick W Christine, Eric J Huang, William W Seeley, Bruce L Miller, Steven J DeArmond, Lea T Grinberg, Michael D Geschwind
A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started walking cautiously. After 1 year, her depression resolved but she developed a dry cough. One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horizontal and vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2 years later. The differential diagnosis, neuroimaging, and pathological findings are discussed, as well as their public health implications...
March 6, 2017: JAMA Neurology
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