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JAMA Dermatology

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https://www.readbyqxmd.com/read/30208477/use-of-topical-glycolic-acid-plus-a-lovastatin-cholesterol-combination-cream-for-the-treatment-of-autosomal-recessive-congenital-ichthyoses
#1
Samar Khalil, Tara Bardawil, Serena Saade, Adele Chedraoui, Nehmat Ramadan, Divina Justina Hasbani, Ossama Abbas, Georges Nemer, Nelly Rubeiz, Mazen Kurban
Importance: Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of disorders caused by defects in signaling pathways involved in epidermal proliferation and differentiation, leading to a wide range of skin manifestations. Therapeutic options are limited and often unsatisfactory. Topical cholesterol and statin as a combined formulation has proven successful in the treatment of patients with CHILD syndrome (congenital hemidysplasia ichthyosis and limb defects). Objective: To assess change in disease severity score after a 3-month therapeutic regimen consisting of a glycolic acid, 10% to 20%, cream and a combination cream of lovastatin, 2%, with cholesterol, 2%, in the treatment of ARCI...
September 12, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30208474/management-of-flat-pigmented-spitz-and-reed-nevi-in-children
#2
Aimilios Lallas, Zoe Apalla, Chryssoula Papageorgiou, George Evangelou, Dimitrios Ioannides, Giuseppe Argenziano
No abstract text is available yet for this article.
September 12, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30208473/picosecond-laser-treatment-for-acquired-bilateral-nevus-of-ota-like-macules
#3
Tin Hau Sky Wong
No abstract text is available yet for this article.
September 12, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30208471/trajectories-of-nevus-development-from-age-3-to-16-years-in-the-colorado-kids-sun-care-program-cohort
#4
Nancy L Asdigian, Anna E Barón, Joseph G Morelli, Stefan T Mokrohisky, Jenny Aalborg, Robert P Dellavalle, Matthew F Daley, Marianne Berwick, Keith E Muller, Neil F Box, Lori A Crane
Importance: Nevi are a risk factor for melanoma and other forms of skin cancer, and many of the same factors confer risk for both. Understanding childhood nevus development may provide clues to possible causes and prevention of melanoma. Objectives: To describe nevus acquisition from the ages of 3 to 16 years among white youths and evaluate variation by sex, Hispanic ethnicity, and body sites that are chronically vs intermittently exposed to the sun. Design, Setting, and Participants: This annual longitudinal observational cohort study of nevus development was conducted between June 1, 2001, and October 31, 2014, among 1085 Colorado youths...
September 12, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30193374/laser-treatment-performed-more-than-4-decades-after-napalm-burns-healing-the-scars-of-the-napalm-girl
#5
Jill S Waibel, Kim Phuc Phan Thi, Leonard J Hoenig
No abstract text is available yet for this article.
September 5, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30193360/predictions-surprises-and-the-future-of-the-dermatology-workforce
#6
Martina L Porter, Alexa B Kimball
No abstract text is available yet for this article.
September 5, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30193349/comparison-of-dermatologist-density-between-urban-and-rural-counties-in-the-united-states
#7
Hao Feng, Juliana Berk-Krauss, Paula W Feng, Jennifer A Stein
Importance: As the US population continues to increase and age, there is an unmet need for dermatologic care; therefore, it is important to identify and understand the characteristics and patterns of the dermatologist workforce. Objective: To analyze the longitudinal dermatologist density and urban-rural disparities using a standardized classification scheme. Design, Setting, and Participants: This study analyzed county-level data for 1995 to 2013 from the Area Health Resources File to evaluate the longitudinal trends and demographic and environmental factors associated with the geographic distribution of dermatologists...
September 5, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30193331/necrotic-plaque-on-the-distal-nose-with-diffuse-crateriform-nodules
#8
Karlyn Pollack, Darren Guffey, Alejandro A Gru
No abstract text is available yet for this article.
September 5, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30193300/assessment-of-treatment-of-refractory-granuloma-faciale-with-intralesional-rituximab
#9
Daniel Morgado-Carrasco, Priscila Giavedoni, José M Mascaró, Pilar Iranzo
Importance: Granuloma faciale (GF) is a rare, benign inflammatory dermatosis of unknown cause. Some reports have suggested that it could be part of the spectrum of IgG4-related sclerosing diseases. Granuloma faciale is characterized by single or multiple red-brown nodules, most frequently occurring on the face, and it can produce severe disfigurement. Treatment is difficult, and poor outcomes are often seen. Rituximab is a monoclonal antibody against CD-20 approved by the US Food and Drug Administration for treatment of some autoimmune and tumoral diseases...
September 5, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30193251/complementary-and-alternative-medicine-therapies-for-psoriasis-a-systematic-review
#10
A Caresse Gamret, Alexandra Price, Raymond M Fertig, Hadar Lev-Tov, Anna J Nichols
Importance: Up to 51% of patients with psoriasis report the use of complementary and alternative medicine (CAM) in their treatment regimen, although it is unclear which CAM therapies are effective for treatment of psoriasis. Objective: This review compiles the evidence on the efficacy of the most studied CAM modalities for treatment of patients with plaque psoriasis and discusses those therapies with the most robust available evidence. Evidence Review: PubMed, Embase, and ClinicalTrials...
September 5, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30193335/congenital-syphilis-still-a-shadow-on-the-land
#11
Kenneth A Katz
No abstract text is available yet for this article.
September 4, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30167653/risk-factors-for-dupilumab-associated-conjunctivitis-in-patients-with-atopic-dermatitis
#12
Alison D Treister, Cheryl Kraff-Cooper, Peter A Lio
Importance: Clinical trials of dupilumab for atopic dermatitis (AD) have reported an increased incidence of conjunctivitis in patients who received dupilumab compared with those who received placebo. Objective: To describe the characteristics of patients who develop conjunctivitis secondary to dupilumab treatment for AD. Design, Setting, and Participants: Case series of 12 patients who reported development of conjunctivitis from a cohort of 142 patients treated with dupilumab for AD at a secondary care center from March 14, 2017, to March 29, 2018...
August 29, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30167642/program-director-and-resident-perspectives-on-new-parent-leave-in-dermatology-residency
#13
Lia E Gracey, Morgan Cronin, Kanade Shinkai, Erin F Mathes
No abstract text is available yet for this article.
August 29, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30167641/analysis-of-the-effect-of-gentian-violet-on-apoptosis-and-proliferation-in-cutaneous-t-cell-lymphoma-in-an-in-vitro-study
#14
Jianqiang Wu, Gary S Wood
Importance: Triggering the extrinsic apoptotic pathway is an effective way to kill cutaneous T-cell lymphoma (CTCL) cells in vitro and ex vivo. Objective: To compare small molecules that induce extrinsic apoptosis in CTCL to identify and analyze compounds that induce high levels of tumor cell death and block tumor cell growth. Design, Setting, and Participants: From November 5, 2014, to January 30, 2018, this study performed high-throughput small molecule screening of 1710 compounds followed by detailed analysis of the ability of gentian violet (GV) to promote apoptosis and inhibit proliferation of CTCL cells...
August 29, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30167639/a-child-with-multiple-hypopigmented-macules-on-the-abdomen
#15
Min Wha Choi, June Hyunkyung Lee, Tae Young Han
No abstract text is available yet for this article.
August 29, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30140893/association-between-autoantibody-phenotype-and-cutaneous-adverse-reactions-to-hydroxychloroquine-in-dermatomyositis
#16
Paige W Wolstencroft, Livia Casciola-Rosen, David F Fiorentino
Importance: Hydroxychloroquine sulfate is a commonly used medication for patients with dermatomyositis and has been associated with a uniquely elevated risk of adverse cutaneous reactions in this population. No studies to date have examined whether certain subsets of patients with dermatomyositis are at increased risk of experiencing a hydroxychloroquine-associated skin eruption. Objective: To identify disease features that increase the risk of hydroxychloroquine-associated skin eruption in adults with dermatomyositis...
August 22, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30140888/pathogenetic-characteristics-of-mesenchymal-stem-cells-in-hidradenitis-suppurativa
#17
Anna Campanati, Monia Orciani, Giulia Sorgentoni, Veronica Consales, Annamaria Offidani, Roberto Di Primio
Importance: Hidradenitis suppurativa (HS) is a disease of the terminal hair follicle in apocrine gland-enriched skin areas, where immunobiology dysregulation of mesenchymal stem cells (MSCs) may have a key role. Objective: To investigate the MSC profile in patients with HS and in healthy controls. Design, Setting, and Participants: In this prospective case-control study, patients with HS were recruited from the Dermatological Clinic at the Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy...
August 22, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30140854/how-should-artificial-intelligence-screen-for-skin-cancer-and-deliver-diagnostic-predictions-to-patients
#18
George A Zakhem, Catherine C Motosko, Roger S Ho
No abstract text is available yet for this article.
August 22, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30140851/evaluation-of-a-combined-reflectance-confocal-microscopy-optical-coherence-tomography-device-for-detection-and-depth-assessment-of-basal-cell-carcinoma
#19
Aditi Sahu, Oriol Yélamos, Nicusor Iftimia, Miguel Cordova, Christi Alessi-Fox, Melissa Gill, Gopi Maguluri, Stephen W Dusza, Cristián Navarrete-Dechent, Salvador González, Anthony M Rossi, Ashfaq A Marghoob, Milind Rajadhyaksha, Chih-Shan J Chen
Importance: The limited tissue sampling of a biopsy can lead to an incomplete assessment of basal cell carcinoma (BCC) subtypes and depth. Reflectance confocal microscopy (RCM) combined with optical coherence tomography (OCT) imaging may enable real-time, noninvasive, comprehensive three-dimensional sampling in vivo, which may improve the diagnostic accuracy and margin assessment of BCCs. Objective: To determine the accuracy of a combined RCM-OCT device for BCC detection and deep margin assessment...
August 22, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30140849/dupilumab-for-the-treatment-of-recalcitrant-bullous-pemphigoid
#20
Alex Kaye, Samantha C Gordon, Sandhya C Deverapalli, Min Ji Her, David Rosmarin
No abstract text is available yet for this article.
August 22, 2018: JAMA Dermatology
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