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Scandinavian Journal of Urology

Oystein S Eikrem, Philipp Strauss, Christian Beisland, Andreas Scherer, Lea Landolt, Arnar Flatberg, Sabine Leh, Vidar Beisvag, Trude Skogstrand, Karin Hjelle, Anjana Shresta, Hans-Peter Marti
OBJECTIVE: A previous study by this group demonstrated the feasibility of RNA sequencing (RNAseq) technology for capturing disease biology of clear cell renal cell carcinoma (ccRCC), and presented initial results for carbonic anhydrase-9 (CA9) and tumor necrosis factor-α-induced protein-6 (TNFAIP6) as possible biomarkers of ccRCC (discovery set) [Eikrem et al. PLoS One 2016;11:e0149743]. To confirm these results, the previous study is expanded, and RNAseq data from additional matched ccRCC and normal renal biopsies are analyzed (confirmation set)...
October 14, 2016: Scandinavian Journal of Urology
Kazuyuki Numakura, Norihiko Tsuchiya, Hiroshi Tsuruta, Susumu Akihama, Mitsuru Saito, Takamitsu Inoue, Shintaro Narita, Mingguo Huang, Shigeru Satoh, Tomonori Habuchi
OBJECTIVE: Intravesical BCG therapy is widely used for the treatment of high-risk, non-muscle-invasive bladder cancer. Among various reported side-effects, decreased bladder capacity is a serious side-effect that significantly worsens patients' quality of life. This article reports the efficacy and safety of bladder hydrodistension (BHD) in six patients with seriously decreased bladder capacity caused by BCG treatment. METHODS: Six patients with low bladder capacity (<100 ml in voiding diaries) and complaint of grade 3 irritative symptoms were diagnosed with decreased bladder capacity and treated with BHD...
October 5, 2016: Scandinavian Journal of Urology
Ikbal Cavdar, Zeynep Temiz, Ayfer Ozbas, Gulbeyaz Can, Fatih Tarhan, Ummu Yildiz Findik, Fatma Yasemin Kutlu, Nuray Akyuz
OBJECTIVE: The aim of this study was to determine the sleep quality and the association between sleep quality and quality of life in people with ileal conduit. MATERIALS AND METHODS: A descriptive and cross-sectional design was adopted. The study sample comprised 111 people with ileal conduit operated on in urology clinics in a state hospital between January 2011 and May 2014. Six months after the operation, they were called by telephone to participate in the study...
October 5, 2016: Scandinavian Journal of Urology
Evert Baten, Murat Akand, Michael S Floyd, Ben Van Cleynenbreugel, Maarten Albersen, Wouter Everaerts, Hendrik Van Poppel, Frank Van Der Aa, Steven Joniau
OBJECTIVE: The aim of this study was to evaluate the risk factors and treatment options for ureteroenteric strictures (UES) following radical cystectomy (RC) and ileal conduit (IC) formation, and specifically to comment on the conservative management of UES in asymptomatic patients. MATERIALS AND METHODS: The datasheets were reviewed of 304 consecutive patients who were treated with an RC and IC between January 2001 and May 2011 in a Belgian tertiary center and who followed a strict follow-up protocol...
September 29, 2016: Scandinavian Journal of Urology
Muammer Altok, Mustafa Güneş, Mehmet Umul, Ali Feyzullah Şahin, Ercan Baş, Taylan Oksay, Sedat Soyupek
OBJECTIVE: One of the factors that determines the treatment success of shockwave lithotripsy (SWL) is the frequency of the shockwaves during the procedure. This study compared the efficacy and pain perception of shockwave frequencies at 30 versus 60 shocks/min for kidney stones. MATERIALS AND METHODS: From August 2013 to May 2015, 160 patients with solitary, radiopaque kidney stones were randomized to SWL at 30 shocks/min (group 1) or 60 shocks/min (group 2), with 80 patients in each group...
September 27, 2016: Scandinavian Journal of Urology
Pete T T Kinnunen, Teemu J Murtola, Kirsi Talala, Kimmo Taari, Teuvo L J Tammela, Anssi Auvinen
OBJECTIVE: Anticoagulants, especially vitamin K antagonists (VKAs) such as warfarin, have been hypothesized to have antitumor properties, and use of VKAs has been associated with a lower prostate cancer (PCa) risk. This study estimated PCa risk among users of warfarin and other anticoagulants. MATERIALS AND METHODS: All anticoagulant use among 78,615 men during 1995-2009 was analyzed. Cox regression, adjusted for age, screening trial arm and use of other medications, with medication use as a time-dependent variable, was used to estimate PCa risk overall, and by tumor grade and stage...
September 14, 2016: Scandinavian Journal of Urology
Jacques Planas, Ana Celma, José Placer, Mercè Cuadras, Lucas Regis, Carlos Gasanz, Enrique Trilla, Carlos Salvador, David Lorente, Juan Morote
OBJECTIVE: The aim of this study was to evaluate hormonal recovery after cessation of androgen deprivation therapy (ADT) in a group of elderly prostate cancer patients. MATERIALS AND METHODS: Forty patients with locally advanced or metastatic prostate cancer, with a mean age of 71.5 years [95% confidence interval (CI) 69.1-73.9], were treated with ADT for a mean duration of 74.6 months (95% CI 59.7-89.5 months). Mean follow-up time after ADT cessation was 36.5 months (95% CI 30...
September 14, 2016: Scandinavian Journal of Urology
Jan Edenberg, Kaja Gløersen, Herzi Abdi Osman, Magne Dimmen, Geir V Berg
OBJECTIVE: Focal renal lesions are common incidental findings on computed tomography (CT). For lesions with a cystic appearance, the Bosniak classification system has enabled an important separation of benign and (potentially) malignant cysts, giving a practical guide for management. The purpose of this study was to evaluate contrast-enhanced ultrasound (CEUS) as a problem-solving modality for classification of indeterminate renal lesions detected with CT. MATERIALS AND METHODS: In total, 140 consecutive patients with 148 indeterminate renal lesions were examined with ultrasound combined with CEUS (81 men and 59 women with mean age 63...
September 9, 2016: Scandinavian Journal of Urology
Ahmed S El-Hefnawy, Tamer Helmy, Mahmoud Laimon, Samer El-Halwagy, Hassan Abol-Enein
OBJECTIVE: The aim of this study was to review different management modalities and outcome of patients presenting with late intestinal obstruction (IO) after radical cystectomy (RC) or palliative cystectomy (PC). MATERIALS AND METHODS: Files of patients who presented with IO between January 1978 and June 2014 were reviewed. Patients who developed IO following either RC or PC more than 30 days after surgery were included. Patients' characteristics and management protocols were evaluated...
September 2, 2016: Scandinavian Journal of Urology
Mikkel Fode, Gyrithe L Pedersen, Nessn Azawi
OBJECTIVE: Between 2012 and 2014, nine consecutive patients with symptomatic urachal remnants were treated at Roskilde Hospital, Denmark, with a robot-assisted laparoscopic en bloc resection of their urachal remnants with partial cystectomy and umbilectomy with primary umbilicoplasty. The objective of this study is to report surgical results and give recommendations for the management of urachal remnants. MATERIALS AND METHODS: The patient group consisted of four women and five men with a median age of 59 years...
August 30, 2016: Scandinavian Journal of Urology
Myong Kim, Geehyun Song, Sang Hyun Park, Mooyoung Sohn, Sang Hoon Song, Hyung Keun Park, Bumsik Hong
OBJECTIVE: The aim of this study was to assess the therapeutic role of ureteral stent removal following balloon dilatation (BD) in patients with a stent implanted for unilateral ureteral obstruction and with normal contralateral renal function. MATERIALS AND METHODS: This retrospective cohort study consisted of 37 consecutive patients with unilateral ureteral obstruction whose stents were removed after BD. All patients satisfied the following criteria: normal contralateral renal function, no evidence of malignancy, and the patient was eager to obtain a stent-free state (SFS) without invasive treatment...
October 2016: Scandinavian Journal of Urology
Sara V Tornberg, Harry Nisen, Harri Visapää, Tuomas P Kilpeläinen, Riikka Järvinen, Tuomas Mirtti, Ilkka Kantonen, Jarmo Simpanen, Petri Bono, Kimmo Taari, Petrus Järvinen
OBJECTIVE: This study evaluated the clinical outcome of patients with renal cell carcinoma (RCC) with tumour thrombus (TT) after surgical management. MATERIALS AND METHODS: In total, 142 consecutive RCC patients with TT who were operated on in Helsinki University Hospital between 2006 and 2014 were analysed. Eighty-eight (62%) of these patients had been operated on with radical intention and 54 (38%) with cytoreductive intention. A total of 73 patients (51%) received postoperative targeted therapy...
October 2016: Scandinavian Journal of Urology
Eero Kaasinen, Hans Wijkström, Erkki Rintala, Oddvar Mestad, Staffan Jahnson, Per-Uno Malmström
OBJECTIVE: The aim of this study was to compare the long-term efficacy of BCG monotherapy to alternating therapy of mitomycin C (MMC) and BCG in patients with carcinoma in situ (CIS). MATERIALS AND METHODS: Between 1992 and 1997, 321 patients with CIS were randomized from Finland, Norway and Sweden in a prospective multicenter trial into two treatment groups. The alternating therapy comprised six weekly instillations of MMC 40 mg followed by 10 instillations of BCG (Connaught 120 mg) or MMC alternating monthly for 1 year...
October 2016: Scandinavian Journal of Urology
Rami Klaff, Eberhard Varenhorst, Anders Berglund, Per Olov Hedlund, Folke Sjöberg, Gabriel Sandblom
OBJECTIVE: The aim of this study was to investigate the impact of bone metastasis on survival and quality of life (QoL) in men with hormone-naïve prostate cancer. MATERIALS AND METHODS: The study included 900 patients from a randomized trial (No. 5) by the Scandinavian Prostate Cancer Group, comparing parenteral oestrogen with total androgen blockade. Extent of bone metastasis was categorized according to a modified Soloway score: score 1, n = 319; score 2, n = 483; and score 3, n = 98 patients...
October 2016: Scandinavian Journal of Urology
Fady Ghali, Rachel A Moses, Eric Raffin, Elias S Hyams
OBJECTIVE: This study sought to evaluate factors associated with unplanned hospital return (UR) following transurethral resection of bladder tumor (TURBT), the largest source of readmission among ambulatory urological procedures. MATERIALS AND METHODS: A retrospective review of TURBTs at a single academic institution between April 2011 and August 2014 was performed. Demographics, comorbidities, length of stay, tumor size and multiple other factors were recorded...
October 2016: Scandinavian Journal of Urology
Anette Svarre Lund, Lars Lund, Morten Jønler, Peder Graversen, Flemming Bro, Michael Borre
OBJECTIVE: The aim of this study was to investigate 3 year follow-up in patients with stable prostate cancer (PCa) managed in a shared care program by general practitioners (GPs) in collaboration with urological departments. PCa patients who have undergone curative treatment or endocrine therapy require long-term follow-up. Until recently, follow-up has primarily been managed by urologists at hospital-based outpatient clinics. However, new organizational strategies are needed to meet the needs of the growing number of elderly, comorbid cancer patients...
October 2016: Scandinavian Journal of Urology
Jeong Ho Kim, Yong Hyun Park, Yong June Kim, Seok Ho Kang, Seok Soo Byun, Sung-Hoo Hong
OBJECTIVE: The aim of this study was to investigate the influence of age at diagnosis on tumor characteristics and cancer-specific survival (CSS) in renal cell carcinoma (RCC). MATERIALS AND METHODS: Data of patients who underwent radical or partial nephrectomy for renal tumor between 2003 and 2011 at multiple institutions were collected. Patients were divided into two groups according to age at diagnosis: 20-39 years and 40-79 years. To adjust for potential baseline confounders, propensity score matching was performed...
October 2016: Scandinavian Journal of Urology
Hemamali Samaratunga, Brett Delahunt, John Yaxley, John R Srigley, Lars Egevad
Gleason grading of prostate cancer has gained worldwide acceptance since its introduction 50 years ago. This system has fulfilled the role of a powerful prognostic indicator for many years and this has influenced treatment. There have been numerous changes to the management and diagnosis of prostate cancer since 1966, including prostate-specific antigen screening, resulting in the early detection of prostate cancer, This has resulted in the evolution of Gleason grading with the informal adoption of a number of alterations...
October 2016: Scandinavian Journal of Urology
Sophie D Fosså, Thomas Bengtsson, Michael Borre, Göran Ahlgren, Antti Rannikko, Alv A Dahl
OBJECTIVE: Although many studies have dealt with adverse effects (AEs) and quality of life (QoL) in prostate cancer (PCa) patients, the quantification of the patients' perspective on AE-related reduction in QoL has been less studied. This study describes the impact of self-reported local (erectile, bowel, urinary dysfunction) or systemic (mental distress, fatigue, virility loss) AEs on QoL reduction. MATERIALS AND METHODS: Nordic PCa patients completed a questionnaire containing 84 multiple-choice questions...
October 2016: Scandinavian Journal of Urology
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