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American Journal of Clinical and Experimental Immunology

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https://www.readbyqxmd.com/read/30245921/melanocortin-4-receptor-in-subthalamic-nucleus-is-involved-in-the-modulation-of-nociception
#1
Dong-Ji Han, Zhi-Gang He, Hui Yang
Deep brain stimulation of the subthalamic nucleus (STN-DBS) stimulation produces significant improvement of overall pain related to Parkinson disease; however, the mechanisms underlying analgesic effects of STN-DBS are still unknown. This report describes direct neuroanatomical evidence for the central melanocortinergic-opioidergic circuits in the STN. We investigated melanocortin-4 receptor (MC4R) and mu-opioid receptor (MOR)-positive expression of the STN in MC4R-GFP transgenic mice using fluorescence immunohistochemical detection...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30245920/induction-therapy-downregulates-the-expression-of-th17-tfh-cytokines-in-patients-with-active-lupus-nephritis
#2
Na Wang, Congcong Gao, Siwan Cui, Yilu Qin, Chunyi Zhang, Peiwen Yi, Xueqi Di, Shengyun Liu, Tianfang Li, Guanmin Gao, Zhaohui Zheng
To determine the potential changes of IL-6, IL-17A and IL-21 levels during induction therapy, and to assess their relationship with disease activity and immunologic features on patients with active lupus nephritis, twenty-eight patients treated with corticosteroid and immunosuppressants were included in this study. Demographic, clinical, serological data and disease activity were assessed. Blood samples were collected at week 0, 12 and 24, and serum concentrations of IL-17A, IL-6 and IL-21 were measured by cytometric bead array...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30245919/effects-of-allergic-stimulation-and-glucocorticoids-on-mir-155-in-cd4-t-cells
#3
Elizabeth Daniel, Alanna Roff, Man-Hsun Hsu, Ronaldo Panganiban, Kristin Lambert, Faoud Ishmael
RATIONALE: MicroRNAs (miRNAs) are emerging as important regulators of allergic inflammation and potential therapeutic targets. We sought to identify which miRNAs are expressed in CD4+ T-cells and determine whether allergic stimuli or glucocorticoids alter their expression. METHODS: After IRB approval, blood was collected from dust mite (DM) allergic rhinitis subjects (n=20), non-allergic controls (n=8), and asthmatics (n=16). Peripheral blood mononuclear cells were incubated with dust mite extract (DME), diluent control, or DME + dexamethasone (0...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30038846/the-effect-of-icariin-on-immunity-and-its-potential-application
#4
REVIEW
Rong Shen, Ju-Hua Wang
Icariin (ICA) is a major bioactive monomer belonging to flavonoid glycosides attracted from Epimedium, being a classic tonic agent in traditional Chinese medicine. ICA commonly presents multiple effects such as regulating sex hormones, relieving atherosclerosis and antioxidant activity, etc. Recently, more and more studies have demonstrated the application of ICA in autoimmune diseases such as rheumatoid arthritis, bronchial asthma, multiple sclerosis and systemic lupus erythematosus due to its anti-inflammatory...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29755856/the-guiding-role-of-bone-metabolism-test-in-osteoporosis-treatment
#5
REVIEW
Wei Zhang, Guo-Ji Yang, Shi-Xian Wu, Dong-Qing Li, Ying-Bo Xu, Cheng-Hong Ma, Jun-Ling Wang, Wei-Wen Chen
Osteoporosis (OP) and osteoporotic fractures are becoming a serious health care issue in the world. Calcium and vitamin D are the basic treatment for osteoporosis. Nonetheless, they do not effectively reduce the incidences of fracture. Currently approved treatments for osteoporosis include selective estrogen receptor modulators (SERMs), bisphosphonates, denosumab, teriparatide, calcitonin and others. However, the appearance of some adverse effects including atypical fracture and breast cancer has limited long-term treatments above mentioned...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29755855/association-of-hsp90b1-genetic-polymorphisms-with-efficacy-of-glucocorticoids-and-improvement-of-hrqol-in-systemic-lupus-erythematosus-patients-from-anhui-province
#6
Xiu-Xiu Sun, Su-Su Li, Man Zhang, Qiao-Mei Xie, Jian-Hua Xu, Sheng-Xiu Liu, Yuan-Yuan Gu, Fa-Ming Pan, Jin-Hui Tao, Sheng-Qian Xu, Shuang Liu, Jing Cai, De-Guang Wang, Long Qian, Chun-Huai Wang, Li Lian, Hui Xiao, Pei-Ling Chen, Chun-Mei Liang, You-Bing Fang, Qiang Zhou, Hai-Liang Huang, Hong Su, Hai-Feng Pan, Dong-Qing Ye, Yan-Feng Zou
Objective: The aim of this study was to investigate the associations between HSP90B1 gene polymorphisms and the efficacy of glucocorticoids (GCs) and the improvement of health-related quality of life (HRQoL) in Anhui patients with systemic lupus erythematosus (SLE). Method: A total of 305 patients with SLE were recruited to the study. These patients were treated with GCs for 12 weeks and classified into two groups (sensitivity and insensitivity) according to the response to GCs measured by the scores on SLE disease activity index (SLEDAI)...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29755854/neuroanatomical-autonomic-substrates-of-brainstem-gut-circuitry-identified-using-transsynaptic-tract-tracing-with-pseudorabies-virus-recombinants
#7
Zhi-Gang He, Quan Wang, Run-Shan Xie, Yong-Sheng Li, Qing-Xiong Hong, Hong-Bing Xiang
To investigate autonomic substrates of brainstem-gut circuitry identified using trans-synaptic tracing with pseudorabies virus (PRV)-152, a strain that expresses enhanced green fluorescent protein, and PRV-614, a strain that expresses enhanced red fluorescent protein, injecting into the rat rectum wall. 3-7 days after PRV-152 injection, spinal cord and brainstem were removed and sectioned, and processed for PRV-152 visualization using immunofluorescence labeling against PRV-152. 6 days after PRV-614 injection, brainstem was sectioned and the neurochemical phenotype of PRV-614-positive neurons was identified using double immunocytochemical labeling against PRV-614 and TPH...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29755853/reg3%C3%AE-from-cardiomyocytes-regulated-macrophage-migration-proliferation-and-functional-skewing-in-experimental-autoimmune-myocarditis
#8
Shanshan Zhou, Han Jiang, Han Wang, Hongxiang Lu, Rong Chen, Huaxi Xu, Zhaoliang Su, Xiaoyi Shao
Macrophages play critical roles in inflammatory initiation, development, resolution and cardiac regeneration of myocarditis. However, Reg3β, as a member of regenerating family of proteins, contributes to dedifferentiation of injury cardiomyocytes as well as cardiac function remodeling. It remains unclear whether Reg3β was associated with macrophages reprogramming during autoimmune myocarditis. Our results showed that Reg3β could effectively recruit macrophages, promoted their proliferation and phagocytosis, and facilitated their polarized into M2 macrophages...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29531864/posterior-reversible-encephalopathy-syndrome-pres-attributed-to-mycophenolate-mofetil-during-the-management-of-sle-a-case-report-and-review
#9
Lei Zhang, Jian Xu
Posterior reversible encephalopathy syndrome (PRES) is a rare clinical entity associated with systemic lupus erythematosus which characterized by seizure, headache, and altered mental status. The pathophysiology involves subcortical vasogenic edema secondary to hypertension and endothelial damage. PRES is reversible with withdrawal of the offending agent, strict blood pressure control, and treating the underlying disease. We report present here a patient with lupus nephritis who developed PRES following mycophenolate administration...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29348986/an-immunohistochemical-analysis-of-folate-receptor-beta-expression-and-distribution-in-giant-cell-arteritis-a-pilot-study
#10
Shirley Albano-Aluquin, Jozef Malysz, Vincent R Aluquin, Manohar Ratnam, Nancy Olsen
BACKGROUND: Giant cell arteritis (GCA) is a chronic vasculitis of large and medium vessels in which no targetable biomarkers exist to allow selective treatment, predict disease activity and monitor therapeutic responses. The accessibility of the temporal artery (TA) for biopsy allows morphologic studies to characterize macrophages and T cells in the microenvironment of the arterial wall. We evaluated the expression of folate receptor beta (FRB), a candidate diagnostic/therapeutic biomarker, compared its expression with key macrophage markers and correlated it with GCA severity...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29348985/the-effect-and-safety-of-diacerein-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#11
Qi Zhang, Junteng Zhou, Yushu Wang, Decai Chen
The Background: Diacerein has been proposed as a treatment option for management of type 2 diabetes due to its anti-inflammatory properties. PURPOSE: The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to examine the effect and safety of diacerein in patients with type 2 diabetes. DATA SOURCES AND STUDY SELECTION: We searched Pubmed, Embase, and Cochrane Library for RCTs published from database inception to September 2017...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29348984/human-immune-system-during-sleep
#12
REVIEW
Nayyab Asif, Razia Iqbal, Chaudhry Fahad Nazir
A joint function of tissues, organs and cells for the protection of body develops immune system. The human immune response against various infections during sleep, its mechanism, neuroimmune interactions, immunoregulatory effect of sleep along with sleep deprivation and role of cytokines in sleep deprivation were addressed. It is revealed that human immune system and sleep both are associated and influenced by each other. Sleep deprivation makes a living body susceptible to many infectious agents. In the result, immune system of human body is altered by releasing immunomodulators in the response of infections as reported by various researchers...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29181273/optimizing-peptide-epitope-based-autoantibody-detection-in-cancer-patients
#13
Maize Wang, Shirley H Lomeli, Wilbur A Franklin, Sarah Lee, Allan J Pantuck, Gang Zeng
Autoantibody (autoAb) response is an important arm of endogenously arising anti-tumor immune responses, and has received new attention as a cancer biomarker with the recent success of immune check-point inhibitor therapy. Our laboratory has been focusing on measuring autoAb against B-cell epitopes in order to bypass the necessity to purify a panel of recombinant proteins. In order to optimize peptide-based autoAb measurement and to increase sensitivities to cover more patients, we developed a new approach of using mixed peptides to conjugate on the same microsphere and compared its results with the use of a dominant peptide epitope using Luminex microbead-based multiplex assays...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29181272/new-insights-in-the-use-of-immunoglobulins-for-the-management-of-immune-deficiency-pid-patients
#14
REVIEW
Gergely Krivan, Stephen Jolles, Eduardo Lopes Granados, Phillipe Paolantonacci, Rabye Ouaja, Ousmane Alfa Cissé, Ewa Bernatowska
Immunoglobulin replacement therapy (IRT) is standard treatment for patients with primary immunodeficiency (PID). Because most of the patients with PID will require long life-time immunoglobulin replacement therapy, the quality of the prescribed products is of utmost importance. The IRT is generally administered either intravenously (abbreviated IVIG), or subcutaneously (abbreviated SCIG). Both routes have been demonstrated to be effective. The preferred route may vary at different times during a given patient's life...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28804691/combination-of-celecoxib-celebrex-%C3%A2-and-cd19-car-redirected-ctl-immunotherapy-for-the-treatment-of-b-cell-non-hodgkin-s-lymphomas
#15
REVIEW
Tam Nm Dinh, Alexandra S Onea, Ali R Jazirehi
The nonsteroidal anti-inflammatory drug (NSAID) Celecoxib (Celebrex® ) received Food and Drug Administration (FDA) approval in 1998 for treatment of osteoarthritis and rheumatoid arthritis, and in recent years, its use has been extended to various types of malignancies, such as breast, colon, and urinary cancers. To maintain the survival of malignant B cells, non-Hodgkin's Lymphoma (NHL) is highly dependent on inflammatory microenvironment, and is inhibited by celecoxib. Celecoxib hinders tumor growth interacting with various apoptotic genes, such as cyclooxygenase-2 (Cox-2), B-cell lymphoma 2 (Bcl-2) family, phosphor-inositide-3 kinase/serine-threonine-specific protein kinase (PI3K/Akt), and inhibitors of apoptosis proteins (IAP) family...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28337388/the-clinical-significance-of-anti-mitotic-spindle-apparatus-antibody-msa-and-anti-centromere-antibody-aca-detected-in-patients-with-small-cell-lung-cancer-sclc
#16
Liming Tan, Yuhong Zhang, Yongqing Jiang, Hua Li, Juanjuan Chen, Feng Ming, Waimei Wang, Jianlin Yu, Tingting Zeng, Yongjian Tian, Yang Wu
PURPOSE: The project is aimed to detect anti-mitotic spindle apparatus antibody (MSA) and anti-centromere antibody (ACA) and explore the clinical value for the diagnosis of small cell lung cancer (SCLC), providing clinical evidence for molecular studies of SCLC. METHODS: 93 SCLC patients, 208 patients with other cancers and 50 healthy controls were enrolled in this study. MSA antibodies were detected by enzyme linked immunosorbent assay (ELISA). MSA, ACA and anti nuclear antibodies (ANA) were examined by indirect immuno-fluorescence (IIF)...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28337387/pro-and-anti-inflammatory-cytokines-in-children-with-malaria-in-franceville-gabon
#17
Sandrine Lydie Oyegue-Liabagui, Aline Gaëlle Bouopda-Tuedom, Lady Charlène Kouna, Sydney Maghendji-Nzondo, Herman Nzoughe, Nina Tchitoula-Makaya, Irene Pegha-Moukandja, Jean-Bernard Lekana-Douki
Severe Plasmodium falciparum malaria anemia (SMA) is a major cause of mortality in pediatric wards. Variations in inflammatory mediator production play an essential role in disease outcomes. Indeed, several studies have shown the involvement of pro- and anti-inflammatory cytokines such as IFN-γ, IL-6, TNF-α and IL-10 in malaria immunopathology. In other hand the exact role of Th17 cytokines such as IL-17, IL-22 and IL-21 in malaria remains poorly documented. Here, we investigated IFN-γ, TNF-α, IL-6, IL-12, IL-10, IL-4, IL-13, IL-17, IL-22 and IL-21 circulating levels and their association with malaria anemia and parasitemia in Gabonese children...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28123902/expression-of-autophagy-related-genes-mtor-becline-1-lc3-and-p62-in-the-peripheral-blood-mononuclear-cells-of-systemic-lupus-erythematosus
#18
Zhen-Zhen Wu, Jun-Jun Zhang, Cong-Cong Gao, Man Zhao, Sheng-Yun Liu, Guan-Min Gao, Zhao-Hui Zheng
To determine the expression of mTOR, Becline-1, LC3 and p62 in the peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) and assess their relationship with disease activity and immunologic features. The expression of mTOR, Becline-1, LC3 and p62 was detected by RT-PCR in 81 SLE subjects and 86 age- and sex-matched healthy controls. Data regarding demographics and clinical parameters were collected. Disease activity of SLE was evaluated according to the SLE Disease Activity Index (SLEDAI) score...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28078192/etanercept-in-the-treatment-of-refractory-sapho-syndrome
#19
Lei Zhang, Zhaomeng Gao
OBJECTIVE: To explore the application and efficacy of TNF-α inhibitors in the treatment of SAPHO syndrome. METHODS: Two cases of refractory SAPHO syndrome were successfully treated with etanercept. And pain scores, laboratory parameters and functional index were used to judge the efficacies. Literature was also systemically reviewed. RESULTS: Both patients achieved marked clinical remission. There was no obvious toxic or adverse response...
2016: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28078191/comparison-of-single-nucleotide-polymorphisms-snp-at-tnf-%C3%AE-promoter-region-with-tnf-receptor-2-tnfr2-in-susceptibility-to-pulmonary-tuberculosis-using-pcr-rflp-technique
#20
Ehsan Ghamari, Poopak Farnia, Shima Saif, Mehran Marashian, Jaladein Ghanavi, Parissa Farnia, Ali Akbar Velayati
Since apoptosis and survival of the immune cells are crucially important in prevention or predisposition of individual from/to infections, especially in intracellular ones, the current study was performed to assess the correlation of host genetic polymorphisms with susceptibility to TB. For this reason, we investigated the difference of the single nucleotide polymorphisms [SNPs] in tumor necrosis factors [TNF-α] genes at (-238, -308, -857 and -863 position) and tumor necrosis factors receptors two [TNFR2] at (T 587 G position) between patients [n=151] and control [n=83]...
2016: American Journal of Clinical and Experimental Immunology
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