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American Journal of Clinical and Experimental Immunology

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https://www.readbyqxmd.com/read/27335701/high-prevalence-of-hypovitaminosis-d-of-patients-with-autoimmune-rheumatic-diseases-in-china
#1
Zhao-Hui Zheng, Cong-Cong Gao, Zhen-Zhen Wu, Sheng-Yun Liu, Tian-Fang Li, Guan-Min Gao, Zhang-Suo Liu
We aimed to determine the prevalence of hypovitaminosis D in patients with autoimmune rheumatic diseases (ARDs) in China and its association with demographic characteristics of the patients. We recruited 384 patients in this cross-sectional study including 121 cases of systemic lupus erythematosus (SLE), 131 rheumatoid arthritis (RA), 102 spondyloarthritis (SpA) and 30 other ARDs. For each patient, demographic information was collected and serum concentration of 25OHD3 was measured by electrochemiluminescence immunoassay (ECLIA)...
2016: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27168954/reversal-of-oxidative-stress-induced-apoptosis-in-t-and-b-lymphocytes-by-coenzyme-q10-coq10
#2
Sastry Gollapudi, Sudhir Gupta
Coenzyme Q10, (CoQ10) an electron transporter and an antioxidant, protects a variety of cell types against oxidative stress and apoptosis. However, protective effect of CoQ10 on oxidative stress-induced apoptosis in lymphocytes has not been studied in detail. In this study, we investigated the effect of CoQ10 on oxidative stress-induced apoptosis in lymphocytes. An exposure of peripheral blood lymphocytes to oxidative stressors, rotenone or hydrogen peroxide, lead to apoptosis. Pre-treatment of lymphocytes with CoQ10 resulted in a significantly reduced level of oxidative stress-induced apoptosis, which was associated with decreased reactive oxygen species production, an inhibition of mitochondrial membrane depolarization, and inhibition of activation of caspase-9 and caspase-3...
2016: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27168953/inflammasome-il-1-and-inflammation-in-ozone-induced-lung-injury
#3
REVIEW
Chloé Michaudel, Aurélie Couturier-Maillard, Pauline Chenuet, Isabelle Maillet, Catherine Mura, Isabelle Couillin, Aurélie Gombault, Valérie F Quesniaux, François Huaux, Bernhard Ryffel
Exposure to ambient ozone causes airway hyperreactivity and lung inflammation, which represent an important health concern in humans. Recent clinical and experimental studies contributed to the understanding of the mechanisms of epithelial injury, inflammation and airway hyperreactivity, which is reviewed here. The present data suggest that ozone induced oxidative stress causes inflammasome activation with the release of IL-1, other cytokines and proteases driving lung inflammation leading to the destruction of alveolar epithelia with emphysema and respiratory failure...
2016: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27168952/analysis-of-subsets-of-b-cells-breg-cd4treg-and-cd8treg-cells-in-adult-patients-with-primary-selective-igm-deficiency
#4
Ankmalika Gupta Louis, Sudhanshu Agrawal, Sudhir Gupta
Primary selective IgM deficiency (SIGMD) is a rare and recently IUIS-recognized primary immunodeficiency disease with increased susceptibility to infections, allergy, and autoimmune diseases. The pathogenesis of selective IgM remains unclear. The objective of the study was to understand the pathogenesis of selective IgM deficiency via a comprehensive analysis of subsets of B cells, naïve and memory subsets of CD4+ and CD8+ T cells, and Breg, CD4Treg, and CD8Treg cells. Twenty adult patients with SIGMD (serum IgM 4 mg/dl-32 mg/dl) and age-and gender-matched healthy controls were studied...
2016: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27168951/immunotherapy-for-lung-cancer-advances-and-prospects
#5
REVIEW
Li Yang, Liping Wang, Yi Zhang
Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer-related deaths worldwide. To date, surgery is the first choice treatment, but most clinically diagnosed cases are inoperable. While chemotherapy and/or radiotherapy are the next considered options for such cases, these treatment modalities have adverse effects and are sometimes lethal to patients. Thus, new effective strategies with minimal side effects are urgently needed. Cancer immunotherapy provides either active or passive immunity to target tumors...
2016: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26550546/syndrome-of-selective-igm-deficiency-with-severe-t-cell-deficiency-associated-with-disseminated-cutaneous-mycobacterium-avium-intracellulaire-infection
#6
Asal Gharib, Ankmalika Gupta Louis, Sudhanshu Agrawal, Sudhir Gupta
Cutaneous non-disseminated, non-tuberculous mycobacterial infections have been reported in both immunocompetent and immunocompromised subjects. Systemic Mycobacterium avium intracellulaire (MAI) have been reported in non-HIV patients with Idiopathic CD4 lymphocytopenia. We report a comprehensive immunological analysis in syndrome of selective IgM deficiency and T lymphocytopenia (both CD4+ and CD8+) with disseminated cutaneous MAI infection. Naïve (TN) and Central memory (TCM) subsets of both CD4+ and CD8+ T cells were decreased, whereas terminally differentiated effector memory (TEMRA) subset of CD4+ and CD8+ T cells were markedly increased...
2015: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26155434/investigation-of-il-21-gene-polymorphisms-rs2221903-rs2055979-in-cases-with-multiple-sclerosis-of-azerbaijan-northwest-iran
#7
Tohid Gharibi, Tohid Kazemi, Mohammad Reza Aliparasti, Mehdi Farhoudi, Shohreh Almasi, Rashedeh Dehghanzadeh, Narges Seyfizadeh, Zohreh Babaloo
BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the Central Nervous System that is immunologically mediated in genetically susceptible individuals. IL-21, a cytokine produced by TCD4(+) cells, particularly by Th-17 cells, is believed to play an important role in the MS pathogenesis. OBJECTIVE: This study was performed to investigate the impact of genetic polymorphisms in IL-21 gene on MS susceptibility and clinical profiles...
2015: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26155433/glycyrrhizin-down-regulates-ccl2-and-cxcl2-expression-in-cerulein-stimulated-pancreatic-acinar-cells
#8
Yaser Panahi, Shohreh Fakhari, Mehdi Mohammadi, Mohammad Reza Rahmani, Mohammad Saeid Hakhamaneshi, Ali Jalili
Many inflammatory chemokines release from leukocytes and pancreatic acinar cells which play important roles in pathophysiology of acute pancreatitis (AP). Of interests, CXCL2 and CCL2 have been shown elevated in the plasma of patients with AP. We have recently found that Glycyrrhizin (GZ) attenuates AP in mice model. In this study, we aimed to investigate the direct effect of GZ on expression levels of CCL2 and CXCl2 in isolated pancreatic acinar cells. Isolated acinar cells were isolated from the pancreas of healthy C57BL/6 mice, stimulated with cerulein (10(-7) M) and then treated with either PBS or different doses of GZ...
2015: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25628961/association-of-il-13-single-nucleotide-polymorphisms-in-iranian-patients-to-multiple-sclerosis
#9
Narges Seyfizadeh, Tohid Kazemi, Mehdi Farhoudi, Mohammad Reza Aliparasti, Homayoun Sadeghi-Bazargani, Shohreh Almasi, Zohreh Babaloo
MS is an autoimmune disease and interleukin 13 (IL-13) has been proposed to be an important neuroprotective mediator in MS. Because of plausible effect of single nucleotide polymorphisms (SNPs) in expression level or biological activity of any cytokine, we sought to investigate association of IL-13 SNPs, C-1112T, A-1512C and G+2044A, with risk to MS. Sixty-eight RRMS patients and 110 healthy controls were involved in this study. After extraction of genomic DNA, frequency of genotypes and alleles were determined by PCR-RFLP and data were analyzed statistically...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25628960/regulation-of-t-cell-receptor-complex-mediated-signaling-by-ubiquitin-and-ubiquitin-like-modifications
#10
REVIEW
Samantha F Friend, Francina Deason-Towne, Lisa K Peterson, Allison J Berger, Leonard L Dragone
Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging area of investigation...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25143870/g-protein-signaling-modulator-3-a-leukocyte-regulator-of-inflammation-in-health-and-disease
#11
REVIEW
Matthew J Billard, Bryan J Gall, Kristy L Richards, David P Siderovski, Teresa K Tarrant
G protein signaling modulator-3 (GPSM3), also known as G18 or AGS4, is a member of a family of proteins containing one or more copies of a small regulatory motif known as the GoLoco (or GPR) motif. GPSM3 interacts directly with Gα and Gβ subunits of heterotrimeric G proteins to regulate downstream intracellular signals initiated by G protein coupled receptors (GPCRs) that are activated via binding to their cognate ligands. GPSM3 has a selective tissue distribution and is highly expressed in immune system cells; genome-wide association studies (GWAS) have recently revealed that single nucleotide polymorphisms (SNPs) in GPSM3 are associated with chronic inflammatory diseases...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25143869/molecular-analysis-of-interleukin-25-exons-1-and-2-and-its-serum-levels-in-iranian-patients-with-multiple-sclerosis
#12
Mohammad-Reza Javan, Narges Seyfizadeh, Saeed Aslani, Mehdi Farhoodi, Zohreh Babaloo
Overexpression of Interleukin-17 (IL-17) family has been shown in a variety of autoimmune diseases. IL-25 (IL-17E), as a member of this family of cytokines, induces the overexpression of IL-13 and impedes Th17/IL-17 responses. In the present study potential single nucleotide polymorphisms (SNP) of IL-25, its serum level in Multiple Sclerosis (MS) patients have been surveyed. Blood samples were obtained from 100 Relapsing-Remitting MS cases, and 100 healthy controls. Serum levels of IL-25 were measured by ELISA...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25143868/dominant-b-cell-epitopes-from-cancer-stem-cell-antigen-sox2-recognized-by-serum-samples-from-cancer-patients
#13
Julia Shih, Munira Rahman, Quang T Luong, Shirley H Lomeli, Joseph Riss, Robert M Prins, Ali O Gure, Gang Zeng
Human sex determining region Y-box 2 (SOX2) is an important transcriptional factor involved in the pluripotency and stemness of human embryonic stem cells. SOX2 plays important roles in maintaining cancer stem cell activities of melanoma and cancers of the brain, prostate, breast, and lung. SOX2 is also a lineage survival oncogene for squamous cell carcinoma of the lung and esophagus. Spontaneous cellular and humoral immune responses against SOX2 present in cancer patients classify it as a tumor-associated antigen (TAA) shared by lung cancer, glioblastoma, and prostate cancer among others...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25143867/microrna-570-3p-regulates-hur-and-cytokine-expression-in-airway-epithelial-cells
#14
Alanna N Roff, Timothy J Craig, Avery August, Cristiana Stellato, Faoud T Ishmael
Asthma is a chronic lung disease that affects people of all ages and is characterized by high morbidity. The mechanisms of asthma pathogenesis are unclear, and there is a need for development of diagnostic biomarkers and greater understanding of regulation of inflammatory responses in the lung. Post-transcriptional regulation of cytokines, chemokines, and growth factors by the action of microRNAs and RNA-binding proteins on stability or translation of mature transcripts is emerging as a central means of regulating the inflammatory response...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24660122/urinary-tract-infections-in-multiple-sclerosis-under-diagnosed-and-under-treated-a-clinical-audit-at-a-large-university-hospital
#15
Aneesa Mahadeva, Radu Tanasescu, Bruno Gran
Multiple sclerosis (MS) is a chronic demyelinating immune-mediated disease of the central nervous system. Infections have been implicated in different aspects of the disease such as induction of relapses and possibly, progression. Bladder dysfunction and associated urinary tract colonization (UTC) and infections (UTIs) are common in MS patients. UTIs can exacerbate neurological symptoms in MS, whilst high-dose steroid treatment of acute neurological worsening with concurrent untreated UTC may lead to unmasking of infection...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24660121/aberrant-apoptotic-machinery-confers-melanoma-dual-resistance-to-braf-v600e-inhibitor-and-immune-effector-cells-immunosensitization-by-a-histone-deacetylase-inhibitor
#16
Ali R Jazirehi, Ramin Nazarian, Antoni Xavier Torres-Collado, James S Economou
BRAF(V600E)-inhibitors (BRAFi; e.g., vemurafenib) and modern immune-based therapies such as PD-1/PD-L1 and CTLA-4 checkpoints blockade and adoptive cell transfer (ACT) have significantly improved the care of melanoma patients. Having these two effective (BRAFi and immunotherapy) therapies raises the question whether there is a rational biological basis for using them in combination. We developed an in vitro model to determine whether tumor resistance mechanisms to a small molecule inhibitor of a driver oncogene, and to cytotoxic T lymphocyte (CTL)- and natural killer (NK) cell-delivered apoptotic death signals were exclusive or intersecting...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24660120/kindlin-3-in-the-immune-system
#17
REVIEW
Susanna C Fagerholm, Hwee San Lek, Vicky L Morrison
Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24660119/tissue-plasminogen-activator-and-inflammation-from-phenotype-to-signaling-mechanisms
#18
REVIEW
Ling Lin, Kebin Hu
In disease conditions, inflammatory cells, such as neutrophils, T cells, and monocytes/macrophages, are recruited in response to injury cues and express panoply of proinflammatory genes through a combination of transcription factors. Tissue plasminogen activator (tPA), a member of the serine protease family, has been shown to act as cytokine to activate profound receptor-mediated signaling events. In this review, we will discuss the role of tPA in inflammation in various models, and illuminate its signaling mechanisms underlying its modulation of inflammation...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24660118/dust-events-pulmonary-diseases-and-immune-system
#19
REVIEW
Nafiseh Esmaeil, Marjan Gharagozloo, Abbas Rezaei, Gabriele Grunig
Incidences of sand storms have increased in recent years and there is evidence that these dusts can move across long distances. Sand dusts have different adverse effects on health, but one of the most important of them is pulmonary disease. After inhalation of dust, many dust particles are moved to the airways. Dust particles can be sensed by airways epithelial cells, activate macrophages, dendritic cells and innate immune cells and then initiate responses in various populations of specific immune cells such as T helper cells subsets (Th1, Th2, Th17), T cytotoxic cells and B cells...
2014: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24660117/chemerin-regulation-and-role-in-host-defense
#20
REVIEW
Brian A Zabel, Mateusz Kwitniewski, Magdalena Banas, Katarzyna Zabieglo, Krzysztof Murzyn, Joanna Cichy
Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Chemerin message is regulated by nuclear receptor agonists, metabolic signaling proteins and intermediates, and proinflammatory cytokines. Following translation chemerin is secreted as an inactive pro-protein, and its secretion can be regulated depending on cell type. Chemerin bioactivity is largely dependent on carboxyl-terminal proteolytic processing and removal of inhibitory residues...
2014: American Journal of Clinical and Experimental Immunology
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