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Advanced Biomedical Research

Mojgan Karahmadi, Mohammad Javad Tarrahi, Samaneh Sadat Vatankhah Ardestani, Victoria Omranifard, Behdad Farzaneh
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a recent increase in prevalence. A timely appropriate treatment for the disorder may play a crucial role in improvements in behaviors, interactions, and communications in an individual's life. It appears that evaluation of therapeutic approaches to the patients is essential and of importance. Thus, the aim of this study was to evaluate the efficacy of memantine as adjunct therapy in children with ASD. Materials and Methods: This randomized single-blind clinical trial included 60 children with ASD aged <14...
2018: Advanced Biomedical Research
(no author information available yet)
[This corrects the article on p. 59 in vol. 7, PMID: 29862208.].
2018: Advanced Biomedical Research
(no author information available yet)
[This retracts the article on p. 46 in vol. 5, PMID: 27110543.].
2018: Advanced Biomedical Research
Neda Mostofizadeh, Mahshid Gheidarloo, Mahin Hashemipour, Elham Hashemi Dehkordi
Primordial dwarfism (PD) is a group of rare genetically heterogeneous disorders consisted of disorders with intrauterine growth retardation continued through the life. SOFT syndrome with characteristics of short stature, onychodysplasia, facial dysmorphism, and hypotrichosis has been presented as a subtype of PD. Only 20 cases of SOFT syndrome have been reported in world to date, but none of them were not in Iran. Our case was 6.5-year-old girl with a complaint of growth retardation including height of 97 cm (Z = -4...
2018: Advanced Biomedical Research
Arasb Dabbagh-Moghaddam, Majid Kamali, Atefeh Hojjati, Mehdi Foroughi, Reza Ghiasvand, Gholamreza Askari, Javad Hosseinzadeh
Background: Hypertension is one of the most common noncommunicable diseases in the world. One of the most effective factors on blood pressure (BP) is nutrition. The aim of this study was to examine the relationship between dietary patterns and BP among military staffs. Materials and Methods: The study was carried out among 405 military staffs between 22 and 51 years old. Demographic, anthropometric information, and BP of participants were evaluated by standard methods...
2018: Advanced Biomedical Research
Moloud Kazemi, Jaleh Varshosaz, Majid Tabbakhian
Background: Many drugs have poor water solubility and so the oral delivery of such drugs is usually associated with limitation of low bioavailability and lack of dose proportionality. Lipid-based liquid crystal (LC) systems are excellent potential formulations for increasing dissolution and bioavailability of drugs. The aim of the present study was to formulate lipid-based LC containing fenofibrate (FFB) as a hydrophobic drug. Materials and Methods: The studied variables included lipid and stabilizer concentrations and the type of stabilizer...
2018: Advanced Biomedical Research
Moosa Rahimi Ghiasi, Elnaz Rahimi, Zohreh Amirkhani, Rasoul Salehi
Background: Grape exosome-like nanovesicles (GELNs) have the advantage of inherent biocompatibility and biodegradability, the potential to be used as oral delivery vehicles. The objective of this research was to evaluate the efficiency of Syrah GELN purification and their effects on the intestinal stem cells when orally administrated to the rats. Materials and Methods: In this experimental study, Syrah GELN isolated by differential centrifugation and sucrose gradient ultracentrifugation method, then the concentration of protein, size, and zeta potential were measured as well as nanoparticles morphology...
2018: Advanced Biomedical Research
Masoomeh Zivdari, Seyed Hossein Hejazi, Seyed Hossein Mirhendi, Reza Jafari, Hassan-Ali Rastegar, Seyed Mohammad Abtahi
Background: Cutaneous leishmaniasis is one of the most important public health problems in many developing countries. Sand flies, as vectors, transmit infectious forms of the parasite to the vertebrate hosts. Poldokhtar, South West of Iran, is one of the endemic foci of diseases with a little information about it. In this paper, we have tried to gather some useful information to control and to prevent this disease in this region. Materials and Methods: The present study was conducted to determine the vector(s), the parasite, and the species composition of sand flies in the Poldokhtar County during the months from July to September 2015...
2018: Advanced Biomedical Research
Mohammadrasoul Khalkhali, Mahboobeh Golshahi, Tolou Hasandokht, Moosa Kafie, Roghaye Zare
Background: Methamphetamine-induced psychotic disorder (MIP) cannot be easily differentiated from other psychotic disorders. Some studies have reported that patients with MIP and schizophrenia have differences in their cognitive functioning. We hypothesized that their performance would be different on neuropsychological tests which assess executive functions and visual memory. Materials and Methods: In a cross-sectional study, 30 patients with MIP, 31 patients with schizophrenia, and 31 healthy controls were assessed by Rey-Osterrieth complex figure (ROCF) test and visual search and attention test (VSAT)...
2018: Advanced Biomedical Research
Masoud Keikha, Sharareh Moghim, Hossein Fazeli, Bahram Nasr-Esfahani
No abstract text is available yet for this article.
2018: Advanced Biomedical Research
Amin Mahmoudi, Keihan Ghatreh Samani, Effat Farrokhi, Esfandiar Heidarian
Background: Uncoupling protein-1 (UCP-1) is the index protein of the brown adipose tissue (BAT), used in the obesity studies. We evaluated the effects of thymoquinone (TQ), hydroalcoholic, and hexane extracts of Nigella sativa , on the UCP-1 gene expression in BAT, and also on the recovery from oxidative stress, due to a high-fat diet. Materials and Methods: Fifty mice were divided into five groups: the first group was fed with a usual diet and the second, third, fourth, and fifth groups with a high-fat diet, hydroalcoholic extract, hexane extract, and TQ, respectively...
2018: Advanced Biomedical Research
Mohammad Ali Pourmirzaiee, Samaneh Chehrazi, Motahar Heidari-Beni, Roya Kelishadi
Background: The aim of the study was to compare the serum zinc level and eating behaviors in 2-8-year-old children with and without arbitrarily zinc supplementation. Materials and Methods: This case-control study was conducted from December 2015 to December 2017 in Isfahan, Iran. The case group consisted of seventy children, aged 2-8 years, who have received zinc supplement without physician prescription; the controls were an equal number of age-matched children who did not receive any supplement...
2018: Advanced Biomedical Research
Khosro Sardarian, Amir Hossein Maghsood, Marzieh Farimani, Mehrdad Hajiloii, Massoud Saidijam, Mahsa Rezaeepoor, Hanie Mahaki, Alireza Zamani
Background: One of the consequences of toxoplasmosis is the risk of passing it from mother to fetus and the onset of congenital toxoplasmosis during pregnancy. The purpose of this study was to evaluate the B1 gene of Toxoplasma gondii in the placental tissues of pregnant women with acute toxoplasmosis. Materials and Methods: The study was a cross-sectional study. Serum samples of pregnant women who attended to Fatemieh Hospital of Hamadan University of Medical Sciences were tested for immunoglobulin G (IgG) antibodies against T...
2018: Advanced Biomedical Research
Mina Sadat Izadi, Maryam Radahmadi, Maedeh Ghasemi, Atefeh Rayatpour
Background: Exposure to psychological stresses can be a reason for obesity. Therefore, identifying the effective nutritional mechanisms such as feeding markers is of high necessity for the psychological stress conditions. Hence, the present study investigates the effects of subchronic isolation and social stresses on food intake, body weight differences (BWD), and levels of leptin, ghrelin, and glucose in rats. Materials and Methods: Eighteen male rats were randomly allocated into three groups: control (Co), isolation stress (IS), and social stress (SS) groups...
2018: Advanced Biomedical Research
Nael Berri, Jawad Fares, Youssef Fares
Background: Tissue engineering and biomaterials have made it possible to innovate bone treatments for orthopedic and spine problems. The aim of this study is to develop a novel polyethylene oxide (PEO)/silicon-substituted hydroxyapatite (Si-HA) composite to be used as a scaffold for hard tissue engineering in orthopedic and spine procedures. Materials and Methods: The composite was fabricated through the electrospinning technique. The applied voltage (5 kV) and PEO concentration (5%) were fixed...
2018: Advanced Biomedical Research
Fateme Aboutalebi, Hojjatallah Alaei, Shahrbanoo Oryan
Background: The attitude of research on addiction has been done on the key role of glutamate. As a regard, the prelimbic cortex (PrL) has an important role in addiction, learning, and memory. We tried to investigate the level of glutamate and aspartate concentration after glutamate receptors blockade in this region in the morphine-addicted rats. Materials and Methods: In this study, we examined the effects of local infusion of the N-methyl-D-aspartate receptor and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists, 2-amino-5-phosphonovaleric acid (AP5), and 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX), into the PrL cortex on the level of excitatory amino acids (EAAs) and glycine...
2018: Advanced Biomedical Research
Mansour Siavash, Ali Rahrovi, Shokooh Olamazadeh, Morteza Esmaili
No abstract text is available yet for this article.
2018: Advanced Biomedical Research
Alireza Hosseini, Javad Omidian, Reza Nazarzadeh
Background: Acute appendicitis is one of the most commonly diagnosed surgical diseases that its accurate diagnosis is still a problem, and there is no certainty. Ultrasound is recommended for diagnosis of appendicitis as an easy and noninvasive method. Therefore, due to the spread of disease and the urgent need to accurately diagnose in all educational centers, we decided to determine the diagnostic value of this inclusive method in identifying acute appendicitis. Materials and Methods: This is a descriptive cross-sectional research that was conducted on 540 patients referring to Educational Center of Ayatollah Kashani Hospital...
2018: Advanced Biomedical Research
Saeed Majidinejad, Farhad Heidari, Hosein Kafi Kang, Keyhan Golshani
Background: Pelvic fracture (PF) is the second-most prevalent cause of mortality after brain trauma among multiple trauma patients. Our aim was to examine the reliability of suggestive criteria for having no PF (NPF) according to the common reported clinical signs and symptoms (CSSs). Materials and Methods: In the current prospective study, 3527 patients with multiple trauma were recruited according to the guideline of emergency medicine. Information on age, gender, pelvic pain or tenderness, sacrum and coccyx pain or tenderness, the ability to active straight leg raising (SLR), and distracting injury was collected, and PF was examined by either X-ray or computed tomography (CT) scan...
2018: Advanced Biomedical Research
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