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Advanced Biomedical Research

Moosa Rahimi Ghiasi, Elnaz Rahimi, Zohreh Amirkhani, Rasoul Salehi
Background: Grape exosome-like nanovesicles (GELNs) have the advantage of inherent biocompatibility and biodegradability, the potential to be used as oral delivery vehicles. The objective of this research was to evaluate the efficiency of Syrah GELN purification and their effects on the intestinal stem cells when orally administrated to the rats. Materials and Methods: In this experimental study, Syrah GELN isolated by differential centrifugation and sucrose gradient ultracentrifugation method, then the concentration of protein, size, and zeta potential were measured as well as nanoparticles morphology...
2018: Advanced Biomedical Research
Masoomeh Zivdari, Seyed Hossein Hejazi, Seyed Hossein Mirhendi, Reza Jafari, Hassan-Ali Rastegar, Seyed Mohammad Abtahi
Background: Cutaneous leishmaniasis is one of the most important public health problems in many developing countries. Sand flies, as vectors, transmit infectious forms of the parasite to the vertebrate hosts. Poldokhtar, South West of Iran, is one of the endemic foci of diseases with a little information about it. In this paper, we have tried to gather some useful information to control and to prevent this disease in this region. Materials and Methods: The present study was conducted to determine the vector(s), the parasite, and the species composition of sand flies in the Poldokhtar County during the months from July to September 2015...
2018: Advanced Biomedical Research
Mohammadrasoul Khalkhali, Mahboobeh Golshahi, Tolou Hasandokht, Moosa Kafie, Roghaye Zare
Background: Methamphetamine-induced psychotic disorder (MIP) cannot be easily differentiated from other psychotic disorders. Some studies have reported that patients with MIP and schizophrenia have differences in their cognitive functioning. We hypothesized that their performance would be different on neuropsychological tests which assess executive functions and visual memory. Materials and Methods: In a cross-sectional study, 30 patients with MIP, 31 patients with schizophrenia, and 31 healthy controls were assessed by Rey-Osterrieth complex figure (ROCF) test and visual search and attention test (VSAT)...
2018: Advanced Biomedical Research
Masoud Keikha, Sharareh Moghim, Hossein Fazeli, Bahram Nasr-Esfahani
No abstract text is available yet for this article.
2018: Advanced Biomedical Research
Amin Mahmoudi, Keihan Ghatreh Samani, Effat Farrokhi, Esfandiar Heidarian
Background: Uncoupling protein-1 (UCP-1) is the index protein of the brown adipose tissue (BAT), used in the obesity studies. We evaluated the effects of thymoquinone (TQ), hydroalcoholic, and hexane extracts of Nigella sativa , on the UCP-1 gene expression in BAT, and also on the recovery from oxidative stress, due to a high-fat diet. Materials and Methods: Fifty mice were divided into five groups: the first group was fed with a usual diet and the second, third, fourth, and fifth groups with a high-fat diet, hydroalcoholic extract, hexane extract, and TQ, respectively...
2018: Advanced Biomedical Research
Mohammad Ali Pourmirzaiee, Samaneh Chehrazi, Motahar Heidari-Beni, Roya Kelishadi
Background: The aim of the study was to compare the serum zinc level and eating behaviors in 2-8-year-old children with and without arbitrarily zinc supplementation. Materials and Methods: This case-control study was conducted from December 2015 to December 2017 in Isfahan, Iran. The case group consisted of seventy children, aged 2-8 years, who have received zinc supplement without physician prescription; the controls were an equal number of age-matched children who did not receive any supplement...
2018: Advanced Biomedical Research
Khosro Sardarian, Amir Hossein Maghsood, Marzieh Farimani, Mehrdad Hajiloii, Massoud Saidijam, Mahsa Rezaeepoor, Hanie Mahaki, Alireza Zamani
Background: One of the consequences of toxoplasmosis is the risk of passing it from mother to fetus and the onset of congenital toxoplasmosis during pregnancy. The purpose of this study was to evaluate the B1 gene of Toxoplasma gondii in the placental tissues of pregnant women with acute toxoplasmosis. Materials and Methods: The study was a cross-sectional study. Serum samples of pregnant women who attended to Fatemieh Hospital of Hamadan University of Medical Sciences were tested for immunoglobulin G (IgG) antibodies against T...
2018: Advanced Biomedical Research
Mina Sadat Izadi, Maryam Radahmadi, Maedeh Ghasemi, Atefeh Rayatpour
Background: Exposure to psychological stresses can be a reason for obesity. Therefore, identifying the effective nutritional mechanisms such as feeding markers is of high necessity for the psychological stress conditions. Hence, the present study investigates the effects of subchronic isolation and social stresses on food intake, body weight differences (BWD), and levels of leptin, ghrelin, and glucose in rats. Materials and Methods: Eighteen male rats were randomly allocated into three groups: control (Co), isolation stress (IS), and social stress (SS) groups...
2018: Advanced Biomedical Research
Nael Berri, Jawad Fares, Youssef Fares
Background: Tissue engineering and biomaterials have made it possible to innovate bone treatments for orthopedic and spine problems. The aim of this study is to develop a novel polyethylene oxide (PEO)/silicon-substituted hydroxyapatite (Si-HA) composite to be used as a scaffold for hard tissue engineering in orthopedic and spine procedures. Materials and Methods: The composite was fabricated through the electrospinning technique. The applied voltage (5 kV) and PEO concentration (5%) were fixed...
2018: Advanced Biomedical Research
Fateme Aboutalebi, Hojjatallah Alaei, Shahrbanoo Oryan
Background: The attitude of research on addiction has been done on the key role of glutamate. As a regard, the prelimbic cortex (PrL) has an important role in addiction, learning, and memory. We tried to investigate the level of glutamate and aspartate concentration after glutamate receptors blockade in this region in the morphine-addicted rats. Materials and Methods: In this study, we examined the effects of local infusion of the N-methyl-D-aspartate receptor and ╬▒-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists, 2-amino-5-phosphonovaleric acid (AP5), and 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX), into the PrL cortex on the level of excitatory amino acids (EAAs) and glycine...
2018: Advanced Biomedical Research
Mansour Siavash, Ali Rahrovi, Shokooh Olamazadeh, Morteza Esmaili
No abstract text is available yet for this article.
2018: Advanced Biomedical Research
Alireza Hosseini, Javad Omidian, Reza Nazarzadeh
Background: Acute appendicitis is one of the most commonly diagnosed surgical diseases that its accurate diagnosis is still a problem, and there is no certainty. Ultrasound is recommended for diagnosis of appendicitis as an easy and noninvasive method. Therefore, due to the spread of disease and the urgent need to accurately diagnose in all educational centers, we decided to determine the diagnostic value of this inclusive method in identifying acute appendicitis. Materials and Methods: This is a descriptive cross-sectional research that was conducted on 540 patients referring to Educational Center of Ayatollah Kashani Hospital...
2018: Advanced Biomedical Research
Saeed Majidinejad, Farhad Heidari, Hosein Kafi Kang, Keyhan Golshani
Background: Pelvic fracture (PF) is the second-most prevalent cause of mortality after brain trauma among multiple trauma patients. Our aim was to examine the reliability of suggestive criteria for having no PF (NPF) according to the common reported clinical signs and symptoms (CSSs). Materials and Methods: In the current prospective study, 3527 patients with multiple trauma were recruited according to the guideline of emergency medicine. Information on age, gender, pelvic pain or tenderness, sacrum and coccyx pain or tenderness, the ability to active straight leg raising (SLR), and distracting injury was collected, and PF was examined by either X-ray or computed tomography (CT) scan...
2018: Advanced Biomedical Research
Elahe Zarean, Shahrzad Shabaninia
Background: Given the high prevalence of adverse perinatal outcome in the developing countries and the association between uterine artery (UtA) blood flow and fetal status in the uterine, in the current study, we assess the association between UtA pulsatility index (UtA-PI) at 30-34 week's gestation and adverse perinatal outcome. Materials and Methods: This cohort study included 100 pregnant women at 30-34 weeks' gestation. At baseline, UtA-PI was evaluated with color Doppler through abdominal ultrasound...
2018: Advanced Biomedical Research
Armindokht Shahsanai, Ziba Farajzadegan, Zahra Hadi Sichani, Kamal Heidari, Razieh Omidi
Background: Anthropometric indices are one of the ways to assess physical growth and nutritional status of children and adolescents considering the importance of nutrition in children and the role of healthy nutrition in preventing diabetes, obesity and other chronic diseases, the objective of this study is determine the relationship between nutritional knowledge and anthropometric indices in children and adolescents in Isfahan. Materials and Methods: This survey conducted using multistage cluster sampling on 1776 students aged 15-7 years old in Esfahan province in 2015...
2018: Advanced Biomedical Research
Saeede Enteshari, Jaleh Varshosaz
Background: Domperidone (DOM), a dopamine receptor antagonist, is used as antiemetic for the treatment of gastroparesis, vomiting, and nausea. The low water solubility of DOM leads to a low dissolution rate and variable bioavailability. The aim of this study was to enhance the solubility of DOM by the preparation of micron-sized particles. Materials and Methods: The in situ micronization process was carried out using solvent change method in the presence of Soluplus® or PEG6000 as stabilizing agents...
2018: Advanced Biomedical Research
Golnaz Vaseghi, Farideh Hajakbari, Shabnam Sajjadi, Nasim Dana, Ahmad Ghasemi, Afsaneh Yegdaneh
Background: Marine organisms produce a variety of compounds with pharmacological activities, including anticancer effects. They contain several secondary metabolites with interesting biological activities. This study attempted to find cytotoxicity of Hexane, Dichloromethane and Butanol partitions of Holothuria leucospilota and Echinometra mathaei . Materials and Methods: H. leucospilota and E. mathaei were collected from Persian Gulf. The animals were extracted by maceration with methanol-ethyl acetate (1:1)...
2018: Advanced Biomedical Research
Nasimeh Vatandoust, Farzaneh Rami, Ahmad Reza Salehi, Sharifeh Khosravi, Gholamreza Dashti, Gilda Eslami, Sedigheh Momenzadeh, Rasoul Salehi
Background: The previously established methods for type 2 diabetes (T2D) have mainly concentrated on overt diabetes model development. Here, our intention was to create an animal model passing through distinct phases such as obesity with insulin resistance, prediabetes, and gradual progress to the overt diabetes stage. A high-fat high-carbohydrate diet formulation was prescribed combined with multiple low-dose streptozotocin (STZ) injections after obesity establishment. Materials and Methods: Sixteen male Wistar rats were separated randomly into two groups and fed a normal diet for 1 week after which the body weight and biochemical indices of each rat were measured and recorded...
2018: Advanced Biomedical Research
Elham Hashemi Dehkordi, Payam Sobhani, Nabiolah Asadpour, Mahin Hashemipour, Neda Mostofizadeh
Carnitine membrane transporter deficiency or primary carnitine deficiency (PCD) is an autosomal recessive disorder of fatty acid oxidation, in which the transport of carnitine into cells is impaired. Carnitine plays an important role in transporting fatty acids into the mitochondria and carnitine deficiency block oxidation of long-chain fatty acids in the mitochondria that leads to heart and hepatic disease, myopathy, nonketotic hypoglycemia, and neurological complications. PCD has a wide range of symptoms and can reveal itself as symptomatic cardiomyopathy or even asymptomatic...
2018: Advanced Biomedical Research
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