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Advanced Biomedical Research

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https://www.readbyqxmd.com/read/28401080/comparison-of-the-frequency-of-y-short-tandem-repeats-markers-between-sadat-and-non-sadat-populations-in-isfahan-province-of-iran
#1
Reihaneh Seyedebrahimi, Ebrahim Esfandiari, Bahman Rashidi, Rasoul Salehi, Ali Gholami Dahghi, Shahriar Dabiri, Majid Kheirollahi
BACKGROUND: Y chromosome is one of the two sex chromosomes and is male specific. Due to limited genetic exchange, the main part of that is passed virtually unchanged from one generation to next generation. The short tandem repeats (STRs) are almost constant on chromosomes that make them as an appropriate factor for use in population genetic studies. In this study, we used the STRs of Y chromosome markers in Sadat families and comparison with other families was investigated. MATERIALS AND METHODS: In this study, sampling was done from fifty unrelated males of Sadat families and fifty unrelated males of non-Sadat families...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401079/mutation-in-%C3%AE-sg-gene-in-familial-dilated-cardiomyopathy
#2
Marzieh Asadi, Roger Foo, Ahmad Reza Salehi, Rasoul Salehi, Mohammad Reza Samienasab
BACKGROUND: Mutations in different genes including dystrophin-associated glycoprotein complex caused familial dilated cardiomyopathy which is a genetically heterogeneous disease. The δ-SG gene contains nine exons spanning a 433-kb region of genomic DNA. It encodes a 35-kDa, singlepass, and type II transmembrane glycoprotein. MATERIALS AND METHODS: In this study for the first time in Iran we screened 6 patients of a large family that they had positive family history of MI or sudden death by next generation sequencing method...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401078/probiotics-a-new-era-of-biotherapy
#3
REVIEW
Abhijeet Alok, Indra Deo Singh, Shivani Singh, Mallika Kishore, Prakash Chandra Jha, Md Asad Iqubal
Probiotics or health-beneficial bacteria have only recently been introduced in dentistry after years of successful use in mainly gastrointestinal disorders. The concept of bacteriotherapy was first introduced in the beginning of 20(th) century. They are administered in different quantities that allow for colon colonization. These products help in stimulating health promoting flora and also suppressing the pathologic colonization and disease spread. The use of probiotic plays an important aspect in dentistry too, ever since the oral infections occupied the prime spot among the other infections affecting the humans...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401077/comparison-of-ifosfamide-carboplatin-and-etoposide-versus-etoposide-steroid-and-cytarabine-cisplatin-as-salvage-chemotherapy-in-patients-with-refractory-or-relapsed-hodgkin-s-lymphoma
#4
Valiollah Mehrzad, Farzaneh Ashrafi, Ali Reza Farrashi, Reyhaneh Pourmarjani, Mehdi Dehghani, Armindokht Shahsanaei
BACKGROUND: Refractory or relapsed Hodgkin's disease (HD) occurs in 10-50% of patients. The treatment of choice for these patients is high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT). Response to salvage chemotherapy (SCT) partial remission (PR) is necessary before HDCT with ASCT. However, its applicability is restricted mostly to patients responding to salvage chemotherapy. Optimal salvage regimen for these patients is unclear. In this study, our aim was to compare the efficacy profiles of ifosfamide, carboplatin, and etoposide (ICE) and etoposide-steroid-cytarabine-cisplatin (ESHAP) (cytosine arabinoside, cisplatin, and dexamethasone) regimens in the salvage treatment of relapsed or refractory HD...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401076/presentation-of-placental-site-trophoblastic-tumor-with-amenorrhea
#5
Fariba Behnamfar, Safoura Rouholamin, Mahboubeh Esteki
Placental site throphoblastic tumor (PSTT) is a rare manifestation of gestational trophoblastic neoplasia that may complicate any type of pregnancy. The disease is unique from other type, and is defined by slow growth, low human chorionic gonadotropin (hCG) serum levels, the late-onset metastatic potential, and most significantly, insensitivity to chemotherapy. We describe a case of a 31-year-old woman with prolonged amenorrhea and slightly elevated serum beta hCG (βhCG) level, referred for termination of abnormal pregnancy...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401075/repeated-remote-ischemic-conditioning-effect-on-ankle-brachial-index-in-diabetic-patients-a-randomized-control-trial
#6
Najmeh Shahvazian, Mansour Rafiee, Masoud Rahmanian, Seyed Kazem Razavi-Ratki, Mohammad Hadi Farahzadi
BACKGROUND: Remote ischemic preconditioning (RIPC) is a phenomenon where a short period of ischemia in one organ protects against further ischemia in the other organs. We hypothesized that RIPC occurring in diabetic patients with ankle brachial index (ABI) between 0.70 and 0.90 were included with peripheral arterial disease, would make the better coronary flow resulted in the increasing ABI. MATERIALS AND METHODS: This randomized clinical trial study was done in the Afshar Cardiovascular Hospital in Yazd between 2013 and 2014...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401074/proteus-syndrome-with-arteriovenous-malformation
#7
Ali Asilian, Atefeh Sadat Kamali, Nabet Tajmir Riahi, Neda Adibi, Fatemeh Mokhtari
Proteus syndrome is a rare sporadic disorder that appears with localized macrosomia, congenital lipomatosis, and slow flow vascular malformations, connective tissue nevus, and epidermal nevus. There are usually some manifestations at birth. The vascular abnormalities that have been reported in Proteus syndrome are capillary and slow flow venous malformation. We report a case of a 10-year-old boy with confirmed Proteus syndrome characterized by high flow vascular malformation (arteriovenous [AV] malformation) unlike the usual vascular malformations seen in this syndrome...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401073/structural-insight-into-anaphase-promoting-complex-3-structure-and-docking-with-a-natural-inhibitory-compound
#8
Hamzeh Rahimi, Mohammad Ali Shokrgozar, Armin Madadkar-Sobhani, Reza Mahdian, Alireza Foroumadi, Morteza Karimipoor
BACKGROUND: Anaphase promoting complex (APC) is the biggest Cullin-RING E3 ligase and is very important in cell cycle control; many anti-cancer agents target this. APC controls the onset of chromosome separation and mitotic exit through securin and cyclin B degradation, respectively. Its APC3 subunit identifies the APC activators-Cdh1 and Cdc20. MATERIALS AND METHODS: The structural model of the APC3 subunit of APC was developed by means of computational techniques; the binding of a natural inhibitory compound to APC3 was also investigated...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401072/the-investigation-of-insulin-resistance-in-two-groups-of-epileptic-patients-treated-with-sodium-valproate-and-carbamazepine
#9
Mohammad Reza Najafi, Bahareh Bazooyar, Mohammad Zare, Mohammad Reza Aghaghazvini, Behnaz Ansari, Ali Rajaei, Masoumeh Dashti
BACKGROUND: Valproic acid (VPA) is a widely used broad-spectrum antiepileptic drug for therapy of generalized and focal epilepsies. Cross-sectional studies have suggested that valproate treatment may be associated with hyperinsulinemia. We decided to investigate hyperinsulinemia as a health-threatening side effect of VPA in Iranian epileptic patients. MATERIALS AND METHODS: Body mass index (BMI), lipid profile, fasting serum insulin, fasting blood glucose (FBS), and homeostatic model assessment-insulin resistance (HOMA-IR) were measured in 30 VPA-treated epileptic patients and 30 controls (CBZ-treated)...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401071/identification-of-a-new-single-nucleotide-polymorphism-within-the-apolipoprotein-a5-gene-which-is-associated-with-metabolic-syndrome
#10
Samaneh Salehi, Modjtaba Emadi-Baygi, Majdaddin Rezaei, Roya Kelishadi, Parvaneh Nikpour
BACKGROUND: Metabolic syndrome (MetS) is a common disorder which is a constellation of clinical features including abdominal obesity, increased level of serum triglycerides (TGs) and decrease of serum high-density lipoprotein-cholesterol (HDL-C), elevated blood pressure, and glucose intolerance. The apolipoprotein A5 (APOA5) is involved in lipid metabolism, influencing the level of plasma TG and HDL-C. In the present study, we aimed to investigate the associations between four INDEL variants of APOA5 gene and the MetS risk...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28401070/simple-and-easy-to-perform-preimplantation-genetic-diagnosis-for-%C3%AE-thalassemia-major-using-combination-of-conventional-and-fluorescent-polymerase-chain-reaction
#11
Rasoul Salehi, Sharifeh Khosravi, Mansour Salehi, Majid Kheirollahi, Hossein Khanahmad
BACKGROUND: Thalassemias are the most common monogenic disorders in many countries throughout the world. The best practice to control the prevalence of the disease is prenatal diagnosis (PND) services. Extensive practicing of PND proved effective in reducing new cases but on the other side of this success high abortion rate is hided, which ethically unfair and for many couples, especially with a previous experience of a therapeutic abortion, or moral concerns, is not a suitable choice...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28349025/optimization-of-the-expression-of-dt386-br2-fusion-protein-in-escherichia-coli-using-response-surface-methodology
#12
Fatemeh Shafiee, Mohammad Rabbani, Ali Jahanian-Najafabadi
BACKGROUND: The aim of this study was to determine the best condition for the production of DT386-BR2 fusion protein, an immunotoxin consisting of catalytic and translocation domains of diphtheria toxin fused to BR2, a cancer specific cell penetrating peptide, for targeted eradication of cancer cells, in terms of the host, cultivation condition, and culture medium. MATERIALS AND METHODS: Recombinant pET28a vector containing the codons optimized for the expression of the DT386-BR2 gene was transformed to different strains of Escherichia coli (E...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28349024/the-mediating-role-of-mental-health-in-the-relations-between-dietary-behaviors-and-general-health-a-cross-sectional-study
#13
Shahrzad Nematollahi, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Hamidreza Roohafza, Hamid Afshar, Peyman Adibi, Mohammad Reza Maracy
BACKGROUND: The aim of this study is to find a pathway to explaining the relations between dietary behaviors with mental health and psychological functioning. MATERIALS AND METHODS: This cross-sectional study contains 4763 participants from the employees of Isfahan University of Medical Sciences. In this study, four questionnaires were administered which were provided as follows: demographic characteristics, 21-item dietary behaviors questionnaire, Hospital Anxiety and Depression Scale questionnaire, and 12-item General Health Questionnaire (GHQ-12)...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28349023/fractional-carbon-dioxide-laser-and-its-combination-with-subcision-in-improving-atrophic-acne-scars
#14
Mohammad Ali Nilforoushzadeh, Gita Faghihi, Fariba Jaffary, Elaheh Haftbaradaran, Sayed Mohsen Hoseini, Nafiseh Mazaheri
BACKGROUND: Acne is a very common skin disease in which scars are seen in 95% of the patients. Although numerous treatments have been recommended, researchers are still searching for a single modality to treat the complication due to its variety in shape and depth. We compared the effects of fractional carbon dioxide (CO2) laser alone and in combination with subcision in the treatment of atrophic acne scars. MATERIALS AND METHODS: This clinical trial study was performed in Skin Diseases and Leishmaniasis Research Center (Isfahan, Iran) during 2011-2012...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28349022/evaluating-accuracy-of-free-hand-pedicle-screw-insertion-in-adolescent-idiopathic-scoliosis-using-postoperative-multi-slice-computed-tomography-scan
#15
Mohammadreza Etemadifar, Mohammadhossein Jamalaldini
BACKGROUND: Pedicle screw instrumentation has many advantages for correction of adolescent idiopathic scoliosis (AIS) deformity including better correction and fewer late complications. On the other hand, screw insertion in AIS is challenging. Intraoperative fluoroscopy or navigation techniques are expensive, time-consuming, and exposed to high radiation. Free-hand technique relies on the surgeon's experience and locating the pedicle entry point with anatomical landmarks. There are few studies that evaluated pedicle screw position accuracy with postoperative multi-slice computed tomography scan...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28349021/evaluation-of-diagnostic-values-of-clinical-assessment-in-determining-the-maturation-of-arteriovenous-fistulas-for-satisfactory-hemodialysis
#16
Fereshteh Salimi, Shahab Shahabi, Hamid Talebzadeh, Amir Keshavarzian, Mohammad Pourfakharan, Mansour Safaei
BACKGROUND: Fistulas are the preferred permanent hemodialysis vascular access, but a significant obstacle to increasing their prevalence is the fistula's high "failure to mature" (FTM) rate. This study aimed to identify postoperative clinical characteristics that are predictive of fistula FTM. MATERIALS AND METHODS: This descriptive cross-sectional study was performed on 80 end-stage renal disease patients who referred to Al Zahra Hospital, Isfahan, for brachiocephalic fistula placement...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28349020/treatment-outcome-of-the-drug-resistant-zoonotic-cutaneous-leishmaniasis-by-glucantime
#17
Simindokht Soleimanifard, Reza Arjmand, Sedighe Saberi, Mansoor Salehi, Seyed Hossain Hejazi
BACKGROUND: Resistance of Leishmania species to antimonial drugs has increased. Hence, in the present study Leishmania major isolates were collected from patients with resistance phenotype and the presence/absence of resistance to Glucantime was investigated. MATERIALS AND METHODS: Samples were taken from 10 cutaneous leishmaniasis (CL) patients who had not responded to chemotherapy with Glucantime. Nested polymerase chain reaction (PCR) was performed to identify the isolated species...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28299308/malignant-transformation-of-an-intracranial-extradural-epidermoid-cyst-into-squamous-cell-carcinoma-presented-with-cerebrospinal-fluid-leakage
#18
Bahram Seif, Reza Pourkhalili, Ahmad Shekarchizadeh, Parvin Mahzouni
We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence. Intracranial epidermoid cysts are histologically benign and slow-growing neoplasms. They are congenital lesions that develop from ectodermal remnants during neuroembryogenesis. Malignant transformation of epidermoid cysts into SCC is very rare. Various clinical presentations of these tumors after malignant transformation are mentioned in the literature...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28299307/identification-of-appropriate-housekeeping-genes-for-gene-expression-analysis-in-long-term-hypoxia-treated-kidney-cells
#19
Shiva Moein, Shaghayegh Haghjooy Javanmard, Maryam Abedi, Mohammad Hosein Izadpanahi, Yousof Gheisari
BACKGROUND: Selection of stably expressing housekeeping genes (HKGs) is a crucial step in gene expression analysis. However, there are no universal HKGs for all experiments, and they should be determined by each biologic condition. The aim of this study was to detect appropriate HKGs for kidney cells cultured in long-term hypoxia. MATERIALS AND METHODS: Based on a screening step using a microarray data available from gene expression omnibus database, a set of candidate HKGs were chosen to be assessed in human kidney cells cultured in hypoxic or normoxic conditions for about 2 weeks in a time course manner...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28299306/expression-of-estrogen-receptor-alpha-in-malignant-melanoma
#20
Parvin Rajabi, Marzieh Bagheri, Mohsen Hani
BACKGROUND: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors. The aim of this study was to determine the expression of estrogen receptor alpha (ER-α) in MM in Isfahan, Iran. MATERIALS AND METHODS: This study was planned as a descriptive, analytical, cross-sectional investigation. During this study, paraffin-embedded tissue blocks of patients with a histopathologic diagnosis of MM was studied for ER-α using immunohistochemistry (IHC)...
2017: Advanced Biomedical Research
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