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Clinical and Molecular Hepatology

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https://www.readbyqxmd.com/read/29991196/2017-clinical-practice-guidelines-for-liver-cirrhosis-ascites-and-related-complications
#1
(no author information available yet)
No abstract text is available yet for this article.
July 9, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29969885/characterization-and-evaluation-of-liver-fibrosis-grade-in-patients-with-chronic-hepatitis-b-virus-infection-and-normal-transaminases
#2
San Juan López Cristina, Casado Martín Marta, González Sánchez Mercedes, Porcel Martín Almudena, Hernández Martínez Álvaro, Vega Sáenz Jose Luis, Parrón Carreño Tesifón
Backgrounds/Aims: The objective of our study was to determine the epidemiological, laboratory, and serological characteristics of patients with chronic hepatitis B virus (HBV) infection and normal transaminases. The study also aimed to evaluate liver damage by measuring the liver fibrosis (LF) grade and to identify possible factors associated with the presence of fibrosis. Methods: A retrospective observational study was conducted in patients with chronic HBV infection and classified as inactive carriers or immune-tolerant...
July 4, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29940720/effect-of-antiviral-therapy-in-reducing-perinatal-transmission-of-hepatitis-b-virus-and-maternal-outcomes-after-discontinuing-them
#3
Kwang Il Seo, Si Hyun Bae, Pil Soo Sung, Chung-Hwa Park, Hae Lim Lee, Hee Yeon Kim, Hye Ji Kim, Bo Hyun Jang, Jeong Won Jang, Seung Kew Yoon, Jong Young Choi, In-Yang Park, Juyoung Lee, Hyun Seung Lee, Sa-Jin Kim, Jung Hyun Kwon, U Im Chang, Chang Wook Kim, Se Hyun Jo, Young Lee Young Lee, Fisseha Tekle, Jong-Hyun Kim
Background/Aims: There have been numerous efforts to reduce mother-to-child transmission (MTCT) of hepatitis B virus (HBV) with antiviral agents during pregnancy. However, there are limited data regarding the outcomes of pregnant women after delivery. This study was performed to evaluate the efficacy of antiviral agents in preventing MTCT of HBV and maternal long-term outcomes. Methods: The HBV-infected pregnant women treated with antiviral agents to prevent MTCT were retrospectively reviewed...
June 26, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29890569/combined-effects-of-synbiotic-and-sitagliptin-versus-sitagliptin-alone-in-patients-with-nonalcoholic-fatty-liver-disease
#4
Saba Sayari, Hassan Neishaboori, Maryam Jameshorani
Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases in recent years. The aim of this study was to evaluate the effects of sitagliptin with and without a synbiotic supplement in the treatment of patients with NAFLD. Methods: In total, 138 NAFLD patients aged 18-60 years were enrolled in the study. Patients were randomized to one of the following treatments for 16 weeks: Group I (n=68), sitagliptin 50 mg daily plus placebo (one capsule per day) or group II (n=70) sitagliptin 50 mg daily plus synbiotic (one capsule per day)...
June 12, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29886705/transarterial-embolization-for-the-treatment-of-complicated-liver-hemangiomas-a-report-of-two-cases-and-review-of-the-literature
#5
Maria Kalogirou, Danai Chourmouzi, Ioannis Dedes, Stefania Kiapidou, Evangelos Akriviadis, Emmanouil Sinakos
No abstract text is available yet for this article.
June 11, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29865774/efficacy-and-safety-of-sofosbuvir-plus-ribavirin-for-korean-patients-with-hepatitis-c-virus-genotype-2-infection-a-retrospective-multi-institutional-study
#6
Young Min Kim, Seok Bae Kim, Il Han Song, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Seok Hyun Kim, Byung Seok Lee, Hee Bok Chae, Myeong Jun Song, Ji Woong Jang, Soon Yeong Ko, Jae Dong Lee
Background/Aims: Sofosbuvir plus ribavirin is a standard treatment for patients infected with chronic hepatitis C virus (HCV) genotype 2 in Korea. The purpose of this study was to examine the efficacy and safety of this treatment in Korean patients with chronic HCV genotype 2 infection. Methods: We retrospectively analyzed clinical data of patients treated with sofosbuvir plus ribavirin for chronic HCV genotype 2 from May 2016 to December 2017 at eight hospitals located in the Daejeon-Chungcheong area...
June 4, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29716179/recent-update-of-the-2017-korean-association-for-the-study-of-the-liver-kasl-treatment-guidelines-of-chronic-hepatitis-c-comparison-of-guidelines-from-other-continents-2017-aasld-idsa-and-2016-easl
#7
Jong Eun Yeon
The paradigm for the treatment of chronic hepatitis C (CHC) has been changed due to the development of direct acting antivirals (DAAs) of hepatitis C virus (HCV). The high sustained virologic response rate and ease of administration makes the DAAs approach ideal to contribute to the complete eradication of HCV. Currently, treatment options for individual patients vary depending on the genotype or subtype of HCV, presence or absence of liver cirrhosis, previous experience of antiviral treatment or resistance associated substitutions...
May 2, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29706058/clinical-usefulness-of-psoas-muscle-thickness-for-the-diagnosis-of-sarcopenia-in-patients-with-liver-cirrhosis
#8
Dae Hoe Gu, Moon Young Kim, Yeon Seok Seo, Sang Gyune Kim, Han Ah Lee, Tae Hyung Kim, Young Kul Jung, Altay Kandemir, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Soon Ho Um
Background/Aims: The most widely used method for diagnosing sarcopenia is the skeletal muscle index (SMI). Several studies have suggested that psoas muscle thickness per height (PMTH) is also effective for detecting sarcopenia and predicting prognosis in patients with cirrhosis. The aim of this study was to evaluate the optimal cutoff values of PMTH for detecting sarcopenia in cirrhotic patients. Methods: All cirrhotic patients who underwent abdominal computed tomography (CT) scan including L3 and umbilical levels for measuring SMI and transverse psoas muscle thickness, respectively, were included...
April 30, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29684978/evolution-of-glomerular-filtration-rates-and-neutrophil-gelatinase-associated-lipocalin-during-treatment-with-direct-acting-antivirals
#9
Alessio Strazzulla, Giuseppe Coppolino, Giorgio Settimo Barreca, Innocenza Gentile, Laura Rivoli, Maria Concetta Postorino, Maria Mazzitelli, Giuseppe Greco, Chiara Costa, Vincenzo Pisani, Nadia Marascio, Mariadelina Simeoni, Alfredo Focà, Giorgio Fuiano, Daniela Foti, Elio Gulletta, Carlo Torti
Background/Aims: Correct renal function evaluation is based on estimated glomerular filtration rates (eGFR) and complementary renal damage biomarkers, such as neutrophil gelatinase associated lipocalin (NGAL). The aim of this study was to evaluate eGFR and NGAL modifications and renal impairment during treatment with a direct acting antiviral (DAA) for chronic hepatitis C virus (HCV) infection. Methods: A retrospective cohort study evaluated eGFR modification during treatment with DAA...
April 24, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29961305/journal-metrics-of-clinical-and-molecular-hepatology-based-on-the-web-of-science-core-collection
#10
Sun Huh
Background/Aims: Eight years have passed since Clinical and Molecular Hepatology changed its language policy to English-only in September 2010. The journal has been included in PubMed Central since September 2010. Present title continues the Korean Journal of Hepatology since June 2012. It has been indexed in the Web of Science Core Collection as an Emerging Sources Citation Index journal since 2015. I sought to determine whether the change in language policy was successful based on journal metrics...
June 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29544241/epidemiology-of-alcoholic-liver-disease-in-korea
#11
Jae Young Jang, Dong Joon Kim
Alcohol consumption has increased over the past 40 years in Korea concomitantly with the country's rapid socioeconomic development. As a result, alcohol-related deaths and mortality continue to increase in Korea. This review will summarize the recent epidemiology of alcoholic liver disease in Korea.
March 16, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29544240/management-of-hepatitis-c-viral-infection-in-chronic-kidney-disease-patients-on-hemodialysis-in-the-era-of-direct-acting-antivirals
#12
Soon Young Ko, Won Hyeok Choe
The advent of novel, direct-acting antiviral (DAA) regimens for hepatitis C viral (HCV) infection has revolutionized its treatment by producing a sustained virologic response of more than 95% with few side effects and no comorbidities in the general population. Until recently, ideal DAA regimens have not been available to patients with severe renal impairment and end-stage renal disease because there are limited data on the pharmacokinetics, safety, and efficacy of treatment in this unique population. In a hemodialysis context, identifying patients in need of treatment and preventing HCV transmission may also be a matter of concern...
March 16, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29526079/interferon-free-treatment-for-hepatitis-c-virus-infection-induces-normalization-of-extrahepatic-type-i-interferon-signaling
#13
Pil Soo Sung, Eun Byul Lee, Dong Jun Park, Angelo Lozada, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
Background/Aims: Hepatitis C virus (HCV) replicates in the peripheral blood mononuclear cells (PBMCs), leading to the production of type I interferons (IFNs). It is well known that the gene expression profile of PBMC is similar to that of the liver. The present study explored the dynamic gene expression profile of PBMCs collected from HCV-infected patients undergoing direct-acting antiviral (DAA) therapy. Methods: A prospective cohort comprising 27 patients under DAA therapy was formed...
March 12, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29580036/clinical-implication-of-hepatic-volumetry-for-living-donor-liver-transplantation
#14
Woo Kyoung Jeong
No abstract text is available yet for this article.
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29316778/role-of-liver-transplantation-in-severe-alcoholic-hepatitis
#15
REVIEW
Ravi Daswani, Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal, Anil Arora
Severe alcoholic hepatitis has very high short term mortality and corticosteroids have been the mainstay of treatment for decades. Patients with Lille score >0.45 are considered non-responders to steroids and have poor outcome. Recently Orthotopic Liver Transplantation (OLT) is being increasingly used as rescue treatment for these patients, without waiting for 6 months of abstinence. Liver transplant is the only rescue treatment which can potentially provide long term benefit for patients who are steroid non-responders...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29307132/current-epidemiology-and-clinical-characteristics-of-autoimmune-liver-diseases-in-south-korea
#16
REVIEW
Sook-Hyang Jeong
Autoimmune liver diseases including autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are rare diseases. The aim of this review is to examine the epidemiology and clinical characteristics of AIH and PBC in South Korea. There were 4,085 patients registered as AIH in the Rare Intractable Disease Registry of Korea between 2009-2013, with a median age of 56 years and female-to male ratio of 6.4. The age-adjusted incidence and prevalence of AIH were 1.07/100,000/year and 4.82/100,000 persons, respectively...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29254285/picroside-ii-attenuates-fatty-acid-accumulation-in-hepg2-cells-via-modulation-of-fatty-acid-uptake-and-synthesis
#17
Hiteshi Dhami-Shah, Rama Vaidya, Shobha Udipi, Srividhya Raghavan, Shiny Abhijit, Viswanathan Mohan, Muthuswamy Balasubramanyam, Ashok Vaidya
BACKGROUND/AIMS: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could drive the development of potential therapies for Nonalcoholic fatty liver disease. The aim of the current study was to explore the effects of picroside II, a phytoactive found in Picrorhiza kurroa , on fatty acid accumulation vis-à-vis silibinin, a known hepatoprotective phytoactive from Silybum marianum ...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29249129/epidemiology-of-liver-cancer-in-south-korea
#18
REVIEW
Bo Hyun Kim, Joong-Won Park
Liver cancer is the sixth most common cancer (fourth in men and sixth in women) and the second largest cause of cancer mortality in South Korea. The crude incidence rate of liver cancer was 31.9/100,000 (47.5/100,000 in men and 16.2/100,000 in women) and the age-standardized incidence rate was 19.9/100,000 (32.4/100,000 in men and 8.8/100,000 in women) in 2014. The crude incidence rate increased from 1999 to 2011 and thereafter showed a subtle decreasing tendency. The crude prevalence rate was 113.6/100,000 (170...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29249128/prevention-and-management-of-gastroesophageal-varices
#19
REVIEW
Yeon Seok Seo
Bleeding from gastroesophageal varices is a serious complication in patients with liver cirrhosis and portal hypertension. Although there has been significance improvement in the prognosis of variceal bleeding with advancement in diagnostic and therapeutic modalities for its management, mortality rate still remains high. Therefore, appropriate prevention and rapid, effective management of bleeding from gastroesophageal varices is very important. Recently, various studies about management of gastoesophageal varices, including prevention of development and aggravation of varices, prevention of first variceal bleeding, management of acute variceal bleeding, and prevention of variceal rebleeding, have been published...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29151327/serum-matrix-metalloproteinase-1-level-represents-disease-activity-as-opposed-to-fibrosis-in-patients-with-histologically-proven-nonalcoholic-steatohepatitis
#20
Wataru Ando, Hiroaki Yokomori, Nobuhiro Tsutsui, Eigoro Yamanouchi, Yutaka Suzuki, Masaya Oda, Yutaka Inagaki, Katsuya Otori, Isao Okazaki
BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is prevalent in both economically developed and developing countries. Twenty percent of NASH progresses to cirrhosis with/without hepatocellular carcinoma, and there is an urgent need to find biomarkers for early diagnosis and monitoring progression of the disease. Using immunohistochemical and immunoelectron microscopic examination we previously reported that expression of matrix metalloproteinase-1 (MMP-1) increased in monocytes, Kupffer cells and hepatic stellate cells in early stage NASH...
March 2018: Clinical and Molecular Hepatology
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