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Clinical and Molecular Hepatology

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https://www.readbyqxmd.com/read/30419649/influence-of-hepatic-steatosis-on-the-outcomes-of-patients-with-chronic-hepatitis-b-treated-with-entecavir-and-tenofovir
#1
David Sooik Kim, Mi Young Jeon, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Seung Up Kim
Background/Aims: The influence of hepatic steatosis (HS) on chronic hepatitis B (CHB) is unclear. We evaluated the influence of the degree of HS, assessed using the controlled attenuation parameter (CAP) of transient elastography (TE), on treatment outcomes in CHB patients initiated on antiviral therapy. Methods: A total of 334 patients who were initiated on entecavir or tenofovir between 2007 and 2016 with available TE results were recruited. Results: Of the total study population, 146 (43...
November 13, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30408943/endoscopic-treatment-or-balloon-occluded-retrograde-transvenous-obliteration-is-safe-for-patients-with-esophageal-gastric-varices-in-child-pugh-class-c-end-stage-liver-cirrhosis
#2
Keiji Yokoyama, Ryo Yamauchi, Kumiko Shibata, Hiromi Fukuda, Hideo Kunimoto, Kazuhide Takata, Takashi Tanaka, Shinjiro Inomata, Daisuke Morihara, Yasuaki Takeyama, Satoshi Shakado, Shotaro Sakisaka
Background/Aims: There is a controversy about the availability of invasive treatment for esophageal/gastric varices in patients with Child-Pugh class C (CP-C) end-stage liver cirrhosis (LC). We have evaluated the validity of invasive treatment with CP-C end-stage LC patients. Methods: The study enrolled 51 patients with CP-C end-stage LC who had undergone invasive treatment. The treatment modalities included endoscopic variceal ligation in 22 patients, endoscopic injection sclerotherapy in 17 patients, and balloon-occluded retrograde transvenous obliteration (BRTO) in 12 patients...
November 9, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30360030/severe-acute-alcoholic-hepatitis-and-liver-transplant-a-never-ending-mournful-story
#3
Aiman Obed, Abdalla Bashir, Steffen Stern, Anwar Jarrad
Severe acute alcoholic liver disease (SAAH) unresponsive to medical therapy shows one-year-mortality rates of up to 90%. Most transplant centers request six months of alcohol abstinence prior to transplantation, the so-called "6-month rule." This regulation is not based on strong evidence, repeatedly making it a topic of controversial debates. The majority of patients with SAAH will die before fulfilling the 6-month rule. Therefore, liver transplantation (LT) protocols are becoming more flexible towards the rigid abstinence regulation, especially concerning SAAH patients...
October 24, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30360031/association-between-hepatic-steatosis-and-the-development-of-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-b
#4
Yun Bin Lee, Yeonjung Ha, Young Eun Chon, Mi Na Kim, Joo Ho Lee, Hana Park, Kwang-Il Kim, Soo-Hwan Kim, Kyu Sung Rim, Seong Gyu Hwang
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is becoming a worldwide epidemic, and is frequently found in patients with chronic hepatitis B (CHB). We investigated the impact of histologically proven hepatic steatosis on the risk for hepatocellular carcinoma (HCC) in CHB patients without excessive alcohol intake. Methods: Consecutive CHB patients who underwent liver biopsy from January 2007 to December 2015 were included. The association between hepatic steatosis (≥ 5%) and subsequent HCC risk was analyzed...
October 23, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30300990/fatigue-and-weakness-hinder-patient-social-reintegration-after-liver-transplantation
#5
So Hyun Kang, YoungRok Choi, Ho-Seong Han, Yoo-Seok Yoon, Jai Young Cho, Sungho Kim, Kil Hwan Kim, In Gun Hyun, Ahmed Sheta
Background/Aims: With improvements in the survival of liver transplantation (LT) recipients, the focus is shifting to patient quality of life (QOL), and employment is an important factor in aiding the social reintegration of LT patients. This study aims to evaluate the current employment status of liver graft recipients and various factors that may hinder reemployment. Methods: Fifty patients above age 18 who underwent either living or deceased donor LT at a single center from March 2009 to July 2016 were interviewed during their visit to the outpatient clinic...
October 8, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30300991/pathologic-differential-diagnosis-of-metastatic-carcinoma-in-the-liver
#6
Jeong Hwan Park, Jung Ho Kim
The liver is one of the most common sites to which malignancies preferentially metastasize. Although a substantial number of liver malignancies are primary tumors, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, the metastasis of carcinomas to the liver is relatively common and frequently encountered in clinical settings. Representative carcinomas that frequently metastasize to the liver include colorectal carcinoma, breast carcinoma, neuroendocrine tumors, lung carcinoma, and gastric carcinoma...
October 5, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30227702/assessment-of-fibrotic-burden-among-chronic-hepatitis-b-virus-infected-patients-with-normal-transaminase-level
#7
Mi Young Jeon, Beom Kyung Kim, Seung Up Kim
No abstract text is available yet for this article.
September 19, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30184617/viekira-pak-associated-drug-induced-interstitial-lung-disease-case-series-with-systematic-review-of-literature
#8
Yu Jun Wong, Si Yuan Chew, John Chen Hsiang, Prem Harichander Thurairajah, Rahul Kumar, Eng Kiong Teo, Roshni Sadashiv Gokhale, Imran Bin Mohamed Noor, Jessica Tan
No abstract text is available yet for this article.
September 6, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30149691/biochemical-profile-in-an-infant-with-neonatal-hemochromatosis-shows-evidence-of-impairment-of-mitochondrial-long-chain-fatty-acid-oxidation
#9
Karina Lucio de Medeiros Bastos, Caio Robledo Quaio, Fabiana Roberto Lima, Iana Manuelle Araújo, Candice Alves Tavares Araújo, Flávia Balbo Piazzon, Ismael Dale Cotrim Guerreiro da Silva, Gabriel Nuncio Benevides, Ana Cristina Tannuri, Uenis Tannuri, Ramiro Anthero Azevedo, Chong Ae Kim
No abstract text is available yet for this article.
August 28, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30145855/cardiac-diastolic-dysfunction-predicts-poor-prognosis-in-patients-with-decompensated-liver-cirrhosis
#10
Soon Kyu Lee, Myeong Jun Song, Seok Hwan Kim, Hyo Jun Ahn
Background/Aims: Left ventricular diastolic dysfunction (LVDD) is an early manifestation of cardiac dysfunction in patients with liver cirrhosis (LC). However, the effect of LVDD on survival has not been clarified, especially in decompensated LC. Methods: We prospectively enrolled 70 patients with decompensated LC, including ascites or variceal bleeding, at Daejeon St. Mary's Hospital from April 2013 to April 2015. The cardiac function of these patients was evaluated using 2D echocardiography with tissue Doppler imaging...
August 27, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30200750/does-the-old-fashioned-sofosbuvir-plus-ribavirin-treatment-in-genotype-2-chronic-hepatitis-c-patients-still-works-for-koreans
#11
Jong Eun Yeon
No abstract text is available yet for this article.
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30196651/combination-of-synbiotic-and-sitagliptin-in-nonalcoholic-fatty-liver-disease-is-it-better-than-sitagliptin-alone
#12
Yong Kyun Cho
No abstract text is available yet for this article.
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30196650/prognostic-implications-of-trunk-muscle-mass-in-liver-cirrhosis
#13
Jimin Han, Won Kim
No abstract text is available yet for this article.
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/30092624/2017-kasl-clinical-practice-guidelines-management-of-hepatitis-c-treatment-of-chronic-hepatitis-c
#14
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29991196/kasl-clinical-practice-guidelines-for-liver-cirrhosis-ascites-and-related-complications
#15
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29890569/combined-effects-of-synbiotic-and-sitagliptin-versus-sitagliptin-alone-in-patients-with-nonalcoholic-fatty-liver-disease
#16
Saba Sayari, Hassan Neishaboori, Maryam Jameshorani
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases in recent years. The aim of this study was to evaluate the effects of sitagliptin with and without a synbiotic supplement in the treatment of patients with NAFLD. METHODS: In total, 138 NAFLD patients aged 18-60 years were enrolled in the study. Patients were randomized to one of the following treatments for 16 weeks: Group I (n=68), sitagliptin 50 mg daily plus placebo (one capsule per day) or group II (n=70) sitagliptin 50 mg daily plus synbiotic (one capsule per day)...
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29886705/transarterial-embolization-for-the-treatment-of-complicated-liver-hemangiomas-a-report-of-two-cases-and-review-of-the-literature
#17
Maria Kalogirou, Danai Chourmouzi, Ioannis Dedes, Stefania Kiapidou, Evangelos Akriviadis, Emmanouil Sinakos
No abstract text is available yet for this article.
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29865774/efficacy-and-safety-of-sofosbuvir-plus-ribavirin-for-korean-patients-with-hepatitis-c-virus-genotype-2-infection-a-retrospective-multi-institutional-study
#18
Young Min Kim, Suk Bae Kim, Il Han Song, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Seok Hyun Kim, Byung Seok Lee, Hee Bok Chae, Myeong Jun Song, Ji Woong Jang, Soon Young Ko, Jae Dong Lee
BACKGROUND/AIMS: Sofosbuvir plus ribavirin is a standard treatment for patients infected with chronic hepatitis C virus (HCV) genotype 2 in Korea. The purpose of this study was to examine the efficacy and safety of this treatment in Korean patients with chronic HCV genotype 2 infection. METHODS: We retrospectively analyzed clinical data of patients treated with sofosbuvir plus ribavirin for chronic HCV genotype 2 from May 2016 to December 2017 at eight hospitals located in the Daejeon-Chungcheong area...
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29716179/recent-update-of-the-2017-korean-association-for-the-study-of-the-liver-kasl-treatment-guidelines-of-chronic-hepatitis-c-comparison-of-guidelines-from-other-continents-2017-aasld-idsa-and-2016-easl
#19
Jong Eun Yeon
The paradigm for the treatment of chronic hepatitis C (CHC) has been changed due to the development of direct acting antivirals (DAAs) of hepatitis C virus (HCV). The high sustained virologic response rate and ease of administration makes the DAAs approach ideal to contribute to the complete eradication of HCV. Currently, treatment options for individual patients vary depending on the genotype or subtype of HCV, presence or absence of liver cirrhosis, previous experience of antiviral treatment or resistance associated substitutions...
September 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29706058/clinical-usefulness-of-psoas-muscle-thickness-for-the-diagnosis-of-sarcopenia-in-patients-with-liver-cirrhosis
#20
Dae Hoe Gu, Moon Young Kim, Yeon Seok Seo, Sang Gyune Kim, Han Ah Lee, Tae Hyung Kim, Young Kul Jung, Altay Kandemir, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Soon Ho Um
BACKGROUND/AIMS: The most widely used method for diagnosing sarcopenia is the skeletal muscle index (SMI). Several studies have suggested that psoas muscle thickness per height (PMTH) is also effective for detecting sarcopenia and predicting prognosis in patients with cirrhosis. The aim of this study was to evaluate the optimal cutoff values of PMTH for detecting sarcopenia in cirrhotic patients. METHODS: All cirrhotic patients who underwent abdominal computed tomography (CT) scan including L3 and umbilical levels for measuring SMI and transverse psoas muscle thickness, respectively, were included...
September 2018: Clinical and Molecular Hepatology
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