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Clinical and Molecular Hepatology

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https://www.readbyqxmd.com/read/29716179/recent-update-of-the-2017-korean-association-for-the-study-of-the-liver-kasl-treatment-guidelines-of-chronic-hepatitis-c-comparison-of-guidelines-from-other-continents-2017-aasld-idsa-and-2016-easl
#1
Jong Eun Yeon
The paradigm for the treatment of chronic hepatitis C (CHC) has been changed due to the development of direct acting antivirals (DAAs) of hepatitis C virus (HCV). The high sustained virologic response rate and ease of administration makes the DAAs approach ideal to contribute to the complete eradication of HCV. Currently, treatment options for individual patients vary depending on the genotype or subtype of HCV, presence or absence of liver cirrhosis, previous experience of antiviral treatment or resistance associated substitutions...
May 2, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29706058/clinical-usefulness-of-psoas-muscle-thickness-for-the-diagnosis-of-sarcopenia-in-patients-with-liver-cirrhosis
#2
Dae Hoe Gu, Moon Young Kim, Yeon Seok Seo, Sang Gyune Kim, Han Ah Lee, Tae Hyung Kim, Young Kul Jung, Altay Kandemir, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Soon Ho Um
Background/Aims: The most widely used method for diagnosing sarcopenia is the skeletal muscle index (SMI). Several studies have suggested that psoas muscle thickness per height (PMTH) is also effective for detecting sarcopenia and predicting prognosis in patients with cirrhosis. The aim of this study was to evaluate the optimal cutoff values of PMTH for detecting sarcopenia in cirrhotic patients. Methods: All cirrhotic patients who underwent abdominal computed tomography (CT) scan including L3 and umbilical levels for measuring SMI and transverse psoas muscle thickness, respectively, were included...
April 30, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29684978/evolution-of-glomerular-filtration-rates-and-neutrophil-gelatinase-associated-lipocalin-during-treatment-with-direct-acting-antivirals
#3
Alessio Strazzulla, Giuseppe Coppolino, Giorgio Settimo Barreca, Innocenza Gentile, Laura Rivoli, Maria Concetta Postorino, Maria Mazzitelli, Giuseppe Greco, Chiara Costa, Vincenzo Pisani, Nadia Marascio, Mariadelina Simeoni, Alfredo Focà, Giorgio Fuiano, Daniela Foti, Elio Gulletta, Carlo Torti
Background/Aims: Correct renal function evaluation is based on estimated glomerular filtration rates (eGFR) and complementary renal damage biomarkers, such as neutrophil gelatinase associated lipocalin (NGAL). The aim of this study was to evaluate eGFR and NGAL modifications and renal impairment during treatment with a direct acting antiviral (DAA) for chronic hepatitis C virus (HCV) infection. Methods: A retrospective cohort study evaluated eGFR modification during treatment with DAA...
April 24, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29544241/epidemiology-of-alcoholic-liver-disease-in-korea
#4
Jae Young Jang, Dong Joon Kim
Alcohol consumption has increased over the past 40 years in Korea concomitantly with the country's rapid socioeconomic development. As a result, alcohol-related deaths and mortality continue to increase in Korea. This review will summarize the recent epidemiology of alcoholic liver disease in Korea.
March 16, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29544240/management-of-hepatitis-c-viral-infection-in-chronic-kidney-disease-patients-on-hemodialysis-in-the-era-of-direct-acting-antivirals
#5
Soon Young Ko, Won Hyeok Choe
The advent of novel, direct-acting antiviral (DAA) regimens for hepatitis C viral (HCV) infection has revolutionized its treatment by producing a sustained virologic response of more than 95% with few side effects and no comorbidities in the general population. Until recently, ideal DAA regimens have not been available to patients with severe renal impairment and end-stage renal disease because there are limited data on the pharmacokinetics, safety, and efficacy of treatment in this unique population. In a hemodialysis context, identifying patients in need of treatment and preventing HCV transmission may also be a matter of concern...
March 16, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29526079/interferon-free-treatment-for-hepatitis-c-virus-infection-induces-normalization-of-extrahepatic-type-i-interferon-signaling
#6
Pil Soo Sung, Eun Byul Lee, Dong Jun Park, Angelo Lozada, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
Background/Aims: Hepatitis C virus (HCV) replicates in the peripheral blood mononuclear cells (PBMCs), leading to the production of type I interferons (IFNs). It is well known that the gene expression profile of PBMC is similar to that of the liver. The present study explored the dynamic gene expression profile of PBMCs collected from HCV-infected patients undergoing direct-acting antiviral (DAA) therapy. Methods: A prospective cohort comprising 27 patients under DAA therapy was formed...
March 12, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29580036/clinical-implication-of-hepatic-volumetry-for-living-donor-liver-transplantation
#7
Woo Kyoung Jeong
No abstract text is available yet for this article.
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29316778/role-of-liver-transplantation-in-severe-alcoholic-hepatitis
#8
REVIEW
Ravi Daswani, Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal, Anil Arora
Severe alcoholic hepatitis has very high short term mortality and corticosteroids have been the mainstay of treatment for decades. Patients with Lille score >0.45 are considered non-responders to steroids and have poor outcome. Recently Orthotopic Liver Transplantation (OLT) is being increasingly used as rescue treatment for these patients, without waiting for 6 months of abstinence. Liver transplant is the only rescue treatment which can potentially provide long term benefit for patients who are steroid non-responders...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29307132/current-epidemiology-and-clinical-characteristics-of-autoimmune-liver-diseases-in-south-korea
#9
REVIEW
Sook-Hyang Jeong
Autoimmune liver diseases including autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are rare diseases. The aim of this review is to examine the epidemiology and clinical characteristics of AIH and PBC in South Korea. There were 4,085 patients registered as AIH in the Rare Intractable Disease Registry of Korea between 2009-2013, with a median age of 56 years and female-to male ratio of 6.4. The age-adjusted incidence and prevalence of AIH were 1.07/100,000/year and 4.82/100,000 persons, respectively...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29254285/picroside-ii-attenuates-fatty-acid-accumulation-in-hepg2-cells-via-modulation-of-fatty-acid-uptake-and-synthesis
#10
Hiteshi Dhami-Shah, Rama Vaidya, Shobha Udipi, Srividhya Raghavan, Shiny Abhijit, Viswanathan Mohan, Muthuswamy Balasubramanyam, Ashok Vaidya
BACKGROUND/AIMS: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could drive the development of potential therapies for Nonalcoholic fatty liver disease. The aim of the current study was to explore the effects of picroside II, a phytoactive found in Picrorhiza kurroa , on fatty acid accumulation vis-à-vis silibinin, a known hepatoprotective phytoactive from Silybum marianum ...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29249128/prevention-and-management-of-gastroesophageal-varices
#11
REVIEW
Yeon Seok Seo
Bleeding from gastroesophageal varices is a serious complication in patients with liver cirrhosis and portal hypertension. Although there has been significance improvement in the prognosis of variceal bleeding with advancement in diagnostic and therapeutic modalities for its management, mortality rate still remains high. Therefore, appropriate prevention and rapid, effective management of bleeding from gastroesophageal varices is very important. Recently, various studies about management of gastoesophageal varices, including prevention of development and aggravation of varices, prevention of first variceal bleeding, management of acute variceal bleeding, and prevention of variceal rebleeding, have been published...
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29471609/comparison-of-surgical-resection-versus-transarterial-chemoembolization-with-additional-radiation-therapy-in-patients-with-hepatocellular-carcinoma-with-portal-vein-invasion
#12
Jin Wook Chung
No abstract text is available yet for this article.
February 22, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29439305/strategic-application-of-radiotherapy-for-hepatocellular-carcinoma
#13
Seo Hee Choi, Jinsil Seong
With increasing clinical use, radiotherapy (RT) has been considered reliable and effective method for hepatocellular carcinoma (HCC) treatment, depending on extent of disease and patient characteristics. RT for HCC can improve therapeutic outcomes through excellent local control, downstaging, conversion from unresectable to resectable status, and treatments of unresectable HCCs with vessel invasion or multiple intrahepatic metastases. In addition, further development of modern RT technologies, including image-guided radiotherapy (IGRT), intensity-modulated radiotherapy (IMRT), and stereotactic body radiotherapy, has expanded the indication of RT...
February 14, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29353469/management-of-chronic-hepatitis-b-patients-in-immunetolerant-phase-what-latest-guidelines-recommend
#14
Grace Lai-Hung Wong
The natural history of chronic hepatitis B (CHB) is complex and may run through different immune phases that may overlap. In particulars, the immune-tolerant phase is the most interesting and not as well understood as we thought. The concept of true immune tolerance have been under challenged from immunology points of view. The major international guidelines have not yet reached a consensus on the definition of the immune-tolerant phase. While positive hepatitis B e antigen (HBeAg), high serum hepatitis B virus (HBV) DNA and normal serum alanine aminotransferase (ALT) levels are the three key features of this phase, some guidelines also put age into consideration...
January 22, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29665630/comparison-of-surgical-resection-versus-transarterial-chemoembolization-with-additional-radiation-therapy-in-patients-with-hepatocellular-carcinoma-with-portal-vein-invasion
#15
Danbi Lee, Han Chu Lee, Jihyun An, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Young-Hwa Chung, Yung Sang Lee
Background/Aims: Portal vein invasion (PVI) is a poor prognostic factor in patients with hepatocellular carcinoma (HCC). We intended to compare the effects of surgical resection and transarterial chemoembolization (TACE) with additional radiation therapy (RT) in HCC patients with PVI. Methods: The subjects comprised 43 patients who underwent surgical resection for HCC with PVI without previous treatment and another 43 patients who received TACE followed by RT (TACE+RT) as initial treatment who were matched for Child-Pugh class, tumor size, and extent of PVI...
January 16, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29268595/microbiota-a-key-player-in-alcoholic-liver-disease
#16
Anne-Marie Cassard, Dragos Ciocan
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis. The intestinal microbiota (IM) has been recently identified as a key player in the severity of liver injury in ALD. Common features of ALD include a decrease of gut epithelial tight junction protein expression, mucin production, and antimicrobial peptide levels. This disruption of the gut barrier, which is a prerequisite for ALD, leads to the passage of bacterial products into the blood stream (endotoxemia)...
December 22, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29249129/epidemiology-of-liver-cancer-in-south-korea
#17
Bo Hyun Kim, Joong-Won Park
Liver cancer is the sixth most common cancer (fourth in men and sixth in women) and the second largest cause of cancer mortality in South Korea. The crude incidence rate of liver cancer was 31.9/100,000 (47.5/100,000 in men and 16.2/100,000 in women) and the age-standardized incidence rate was 19.9/100,000 (32.4/100,000 in men and 8.8/100,000 in women) in 2014. The crude incidence rate increased from 1999 to 2011 and thereafter showed a subtle decreasing tendency. The crude prevalence rate was 113.6/100,000 (170...
December 18, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29281870/histopathological-evaluation-of-liver-fibrosis-and-cirrhosis-regression
#18
REVIEW
Regina C Lo, Haeryoung Kim
The hepatic repair complex in the setting of cirrhosis has received increasing attention, as it implies the regression of cirrhosis, which was traditionally taken to be an irreversible state. In this brief review, the patterns of fibrosis, the existing staging systems for chronic liver disease and the histopathological features of cirrhosis regression are discussed.
December 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29198095/is-it-possible-to-predict-the-development-of-an-entecavir-resistance-mutation-in-patients-with-chronic-hepatitis-b-in-clinical-practice
#19
Joon Yeul Nam, Jeong-Hoon Lee
No abstract text is available yet for this article.
December 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29179530/lamivudine-fading-into-the-mists-of-time
#20
Jonggi Choi, Young-Suk Lim
No abstract text is available yet for this article.
December 2017: Clinical and Molecular Hepatology
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