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Journal of Applied Biomaterials & Functional Materials

Katarzyna Krysztofiak, Kamila Ciężar, Mikołaj Kościński
BACKGROUND: Daily disposable contact lenses are gaining in popularity among practitioners and wearers for the improved ocular health and subjective outcomes they offer. Recently a novel daily disposable contact lens material with water gradient technology was introduced. Delefilcon A lenses consist of a 33% water content silicone hydrogel core and an outer hydrogel layer which is totally free of silicone and contains 80% water. METHODS: The aim of the present study was to confirm the layered structure of delefilcon A contact lenses...
October 27, 2016: Journal of Applied Biomaterials & Functional Materials
Paola D'Andrea, Deborah Civita, Michela Cok, Luisa Ulloa Severino, Francesca Vita, Denis Scaini, Loredana Casalis, Paola Lorenzon, Ivan Donati, Antonella Bandiera
BACKGROUND: The biochemical, mechanical and topographic properties of extracellular matrix are crucially involved in determining skeletal muscle cell morphogenesis, proliferation and differentiation. Human elastin-like polypeptides (HELPs) are recombinant biomimetic proteins designed to mimic some properties of the native matrix protein; when employed as myoblast adhesion substrates, they stimulate in vitro myogenesis. Given the influence that the biophysical properties of extracellular matrix have on skeletal muscle cells, the aim of this work was to investigate the effects of HELP hydrogels on myoblasts' viability and functions...
October 26, 2016: Journal of Applied Biomaterials & Functional Materials
Candace Colpitts, Amin M Ektesabi, Rachael A Wyatt, Bryan D Crawford, Amirkianoosh Kiani
BACKGROUND: In this study, we investigated a method to produce bioactive hybrid amorphous silicon and silicon oxide patterns using nanosecond laser pulses. METHODS: Microscale line patterns were made by laser pulses on silicon wafers at different frequencies (25, 70 and 100 kHz), resulting in ablation patterns with frequency-dependent physical and chemical properties. RESULTS: Incubating the laser-treated silicon substrates with simulated body fluid demonstrated that the physicochemical properties of the laser-treated samples were stable under these conditions, and favored the deposition of bone-like apatite...
October 8, 2016: Journal of Applied Biomaterials & Functional Materials
Francesco Paolo La Mantia, Manuela Ceraulo, Maria Chiara Mistretta, Marco Morreale
PURPOSE: Biodegradable polymers are currently gaining importance in several fields, because they allow mitigation of the impact on the environment related to disposal of traditional, nonbiodegradable polymers, as well as reducing the utilization of oil-based sources (when they also come from renewable resources). Fibers made of biodegradable polymers are of particular interest, though, it is not easy to obtain polymer fibers with suitable mechanical properties and to tailor these to the specific application...
October 1, 2016: Journal of Applied Biomaterials & Functional Materials
Rossella Arrigo, Elisabetta Morici, Nadka Tzankova Dintcheva
BACKGROUND: This work presents a sustainable approach for the stabilization of polylactic acid (PLA) against thermo-oxidative aging. METHODS: Naturally occurring phenolic and polyphenolic compounds, such as ferulic acid (FerAc), vanillic acid (VanAc), quercetin (Querc) and vitamin E (VitE), were introduced into PLA. RESULTS: The preliminary characterization of the systems formulated containing different amounts of natural stabilizers showed that all compounds used acted as plasticizers, leading to a decrease in rheological functions with respect to neat PLA, without significantly modifying the crystallinity of the raw material...
October 1, 2016: Journal of Applied Biomaterials & Functional Materials
Sydney Peng, Zhi-Teng Lai, Ding-Wei Hong, I-Ming Chu, Po-Liang Lai
BACKGROUND: The aim of this study was to develop a minimally invasive hydrogel system that can release strontium ions, an element that has been shown to increase osteoblast proliferation and prohibit bone resorption, in a controlled manner. METHODS: SrCO3 was selected as the salt of choice due to potential acid neutralization reaction between SrCO3 and degradation by-products of methoxy(polyethylene glycol)-co-poly(lactic-co-glycolic acid) (mPEG-PLGA): namely, lactic acid and glycolic acid...
September 27, 2016: Journal of Applied Biomaterials & Functional Materials
Rebecca L Majewski, Wujie Zhang, Xiaojun Ma, Zhanfeng Cui, Weiping Ren, David C Markel
Bioencapsulation technologies have played an important role in the developing successes of tissue engineering. Besides offering immunoisolation, they also show promise for cell/tissue banking and the directed differentiation of stem cells, by providing a unique microenvironment. This review describes bioencapsulation technologies and summarizes their recent progress in research into tissue engineering. The review concludes with a brief outlook regarding future research directions in this field.
September 26, 2016: Journal of Applied Biomaterials & Functional Materials
Yukinori Maruo, Goro Nishigawa, Masao Irie, Kumiko Yoshihara, Takuya Matsumoto, Shogo Minagi
BACKGROUND: This study evaluated the surface morphology, chemical composition and adhesiveness of lithium disilicate glass ceramic after acid etching with hydrofluoric acid or phosphoric acid. METHODS: Lithium disilicate glass ceramic specimens polished by 600-grit silicon carbide paper were subjected to one or a combination of these surface treatments: airborne particle abrasion with 50-μm alumina (AA), etching with 5% hydrofluoric acid (HF) or 36% phosphoric acid (Phos), and application of silane coupling agent (Si)...
September 17, 2016: Journal of Applied Biomaterials & Functional Materials
Norbert Harrasser, Michael de Wild, Johannes Gorkotte, Andreas Obermeier, Susanne Feihl, Melanie Straub, Ruediger von Eisenhart-Rothe, Hans Gollwitzer, Jasmine Rüegg, Walter Moser, Philipp Gruner, Rainer Burgkart
BACKGROUND: Silver ions (Ag+) have strong antibacterial effects, and silver-coated materials are in widespread clinical use. However, the application of silver-coated medical devices is not without concerns: its use with direct bone contact is not established, and systemic toxic side effects of released Ag+ have been described. Therefore, alternative bactericidal coatings with a more localized way of acting - e.g., calcium dihydroxide, Ca(OH)2 (CH) - would be advantageous. METHODS: A new rat model of the animal's tibial metaphysis was developed...
September 17, 2016: Journal of Applied Biomaterials & Functional Materials
Luca Coluccino, Chiara Peres, Riccardo Gottardi, Paolo Bianchini, Alberto Diaspro, Luca Ceseracciu
BACKGROUND: The knee meniscus is instrumental to stability, shock absorption, load transmission and stress distribution within the knee joint. Such functions are mechanically demanding, and replacement constructs used in meniscus repair often fail because of a poor match with the surrounding tissue. This study focused on the native structure-mechanics relationships and on their anisotropic behavior in meniscus, to define the target biomechanical viscoelastic properties required by scaffolds upon loading...
September 14, 2016: Journal of Applied Biomaterials & Functional Materials
Annapaola Parrilli, Stefano Falcioni, Milena Fini, Saverio Affatato
BACKGROUND: Wear associated with hip components represents the main clinical problem in these patients, and it is important to develop new techniques for more accurate measurements of that wear. Currently, the gravimetric method is the gold standard for assessing mass measurements in preclinical evaluations. However, this method does not give other information such as volumetric loss or surface deviation. This work aimed to develop and validate a new technique to quantify ceramic volume loss from in vitro experiments using micro-computed tomography (micro-CT)...
September 14, 2016: Journal of Applied Biomaterials & Functional Materials
Ebru Kucukyilmaz, Selcuk Savas
BACKGROUND: The aim of this study was to investigate the effectiveness of different remineralization agents by quantitative light-induced fluorescence digital BiluminatorTM (QLF-D). METHODS: Artificial caries lesions were created, and the teeth were divided according to the tested materials: (i) distilled water, (ii) acidulated phosphate fluoride (APF), (iii) Curodont Repair (CR), (iv) ammonium hexafluorosilicate (SiF) and (v) ammonium hexafluorosilicate plus cetylpyridinium chloride (SiF + CPC)...
September 14, 2016: Journal of Applied Biomaterials & Functional Materials
Ana Rita C Duarte, Devid Maniglio, Nuno Sousa, João F Mano, Rui L Reis, Claudio Migliaresi
BACKGROUND: This study investigated the preparation of ordered patterned surfaces and/or microspheres from a natural-based polymer, using the breath figure and reverse breath figure methods. METHODS: Poly(D,L-lactic acid) and starch poly(lactic acid) solutions were precipitated in different conditions - namely, polymer concentration, vapor atmosphere temperature and substrate - to evaluate the effect of these conditions on the morphology of the precipitates obtained...
September 14, 2016: Journal of Applied Biomaterials & Functional Materials
Barbara Del Curto, Paolo Tarsini, Alberto Cigada
BACKGROUND: The aim of this work was the development and characterization of a photocatalytic filter for the treatment of indoor air, characterized by a low pressure drop. METHODS: The filter (photocatalytic filter) was based on a polyester substrate additivated with active carbon (Carbotex 150-6), treated with a sol of titanium dioxide (Sol 121-AB; NextMaterials Ltd.) and illuminated with UV LEDs to induce photocatalytic activity. RESULTS: Tests showed that this filter, used in a suitable device for air circulation with a very low noise level, had the ability to block solid particulates, to photocatalytically oxidize a major fraction of volatile organic compounds (VOCs) and deactivate all of the bacteria blocked on the filter, in contrast to traditional commercial air filters on which the bacteria remain viable...
November 2, 2016: Journal of Applied Biomaterials & Functional Materials
Barbara Del Curto, Nadia Barelli, Mauro Profaizer, Silvia Farè, Maria Cristina Tanzi, Alberto Cigada, Giulia Ognibene, Giuseppe Recca, Gianluca Cicala
BACKGROUND: Until now, environmental sustainability issues are almost entirely unsolved for packaging materials. With the final aim of finding materials with a single recycling channel, cellulose fiber/poly(vinyl)alcohol composites were investigated. METHODS: After extrusion and injection molding, samples of composite with different cellulose fiber content (30%, 50% and 70% w/w) were tested. RESULTS: Tensile mechanical tests exhibited an improvement in composite stiffness when the reinforcement content was increased together with a decrease in composite elongation...
November 2, 2016: Journal of Applied Biomaterials & Functional Materials
Jessica Campos-Delgado, Kelly L S Castro, Jose G Munguia-Lopez, Ana K González, Martin E Mendoza, Benjamin Fragneaud, Raphael Verdan, Joyce R Araujo, Francisco J González, Hugo Navarro-Contreras, Ivan N Pérez-Maldonado, Antonio de León-Rodríguez, Carlos A Achete
BACKGROUND: Driven by the potential biological applications of graphene, many groups have studied the response of cells exposed to graphene oxide (GO). In particular, investigations of bacteria indicate that there are 2 crucial parameters, which so far have only been investigated separately: GO size and exposure methodology. Our study took into account both parameters. We carefully characterized the samples to catalog sizes and structural properties, and tested different exposure methodologies: exposure in saline solution and in the presence of growth media...
September 7, 2016: Journal of Applied Biomaterials & Functional Materials
Nasim Kiaie, Rouhollah Mehdinavaz Aghdam, Seyed Hossein Ahmadi Tafti, Shahriar Hojjati Emami
BACKGROUND: There has been increased attention given to polymeric nanoparticles as protein carriers. In this regard, chitosan/tripolyphosphate (TPP) nanoparticles are considered to be a simple and efficient carrier. However, to have an ideal protein release profile, we need to optimize the properties of the carrier. METHODS: This study examined the influence of 4 critical process parameters on the physicochemical characteristics of final nanoparticles. Chitosan-based nanoparticles were produced by ionic gelation, and then the size, polydispersity and zeta potential of those resulting nanoparticles were evaluated...
September 1, 2016: Journal of Applied Biomaterials & Functional Materials
Wei Liang, Li Li, Xu Cui, Zhongfei Tang, Xiaomou Wei, Haobo Pan, Bing Li
INTRODUCTION: Because of its good osteoconductivity, strontium (Sr) ranelate has been extensively used as a bone substitute for the treatment of bone disorders. To facilitate treatment, Sr is also incorporated into calcium phosphate cement (Sr-CPC); however, the Sr from Sr-CPC is not sufficient to induce a significant increase of bone mass in an ovariectomized rat model. To improve the efficiency of Sr-CPC, we developed a calcitonin gene-related peptide (CGRP)- and Sr-enriched CPC (CGRP-Sr-CPC)...
August 8, 2016: Journal of Applied Biomaterials & Functional Materials
Bogusława Orzechowska-Wylęgała, Dariusz Dobrowolski, Domenico Puzzolo, Bogumił Wowra, Wiktor Niemiec, Adam Wylęgała, Krzysztof Szczubiałka
BACKGROUND: The aim of this study was to investigate the application of mucous membrane keratinocyte cultures on amniotic membrane and on poly(L-lactic acid) (PLLA) Purasorb PL38 to cover tissue loss in the oral cavity. Developments in molecular biology techniques and tissue engineering allow the culturing and identification of cells that can be anchored in the wound to achieve integrity of the tissue. Transplantation of tissues obtained from the patient's own cells is superior to allogenous transplantation where there is a possibility of transfection, rejection and the need for long-term immunosuppression...
August 5, 2016: Journal of Applied Biomaterials & Functional Materials
Martin Stefanic, Xiang Zhang
BACKGROUND: Bioceramic granules are a widely studied material for regeneration of human tissues, and their biological assessment with in vitro cell cultures plays a fundamental role in the development of bioceramics. Design of samples for cell testing represents an important aspect of the biological evaluation, as it dictates how cells will interact with the biomaterial. The aim of this study was to develop samples for cell testing of bioceramic granules with a novel design that would enable direct physical contacts between cells and bioceramic and improved handling properties for efficient laboratory work...
July 2, 2016: Journal of Applied Biomaterials & Functional Materials
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