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Translational Cancer Research

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https://www.readbyqxmd.com/read/30370226/bevacizumab-as-an-adjuvant-therapy-for-glioblastoma-in-elderly-patients-the-facts
#1
Kristopher A Lyon, Jason H Huang
No abstract text is available yet for this article.
August 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30327756/targeting-ros1-rearrangements-in-non-small-cell-lung-cancer-with-crizotinib-and-other-kinase-inhibitors
#2
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B Costa
No abstract text is available yet for this article.
August 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30079300/prostate-cancer-unmet-clinical-needs-and-rad9-as-a-candidate-biomarker-for-patient-management
#3
Howard B Lieberman, Alex J Rai, Richard A Friedman, Kevin M Hopkins, Constantinos G Broustas
Prostate cancer is a complex disease, with multiple subtypes and clinical presentations. Much progress has been made in recent years to understand the underlying genetic basis that drives prostate cancer. Such mechanistic information is useful for development of novel therapeutic targets, to identify biomarkers for early detection or to distinguish between aggressive and indolent disease, and to predict treatment outcome. Multiple tests have become available in recent years to address these clinical needs for prostate cancer...
July 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30443490/gut-microbes-modulate-host-response-to-immune-checkpoint-inhibitor-cancer-immunotherapy
#4
COMMENT
Kebin Liu, Chunwan Lu
No abstract text is available yet for this article.
June 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30221145/matrix-metalloproteinase-mmp-and-immunosuppressive-biomarker-profiles-of-seven-head-and-neck-squamous-cell-carcinoma-hnscc-cell-lines
#5
Amber M Bates, Maria Paula Gomez Hernandez, Emily A Lanzel, Fang Qian, Kim A Brogden
Background: Biomarkers like programmed death ligand-1 (PDL1) have become a focal point for immunotherapeutic checkpoint inhibition in head and neck squamous cell carcinoma (HNSCC). However, it's only part of the total immunosuppressive biomarker profile of HNSCC cells. Matrix metalloproteinases (MMPs) are enzymes that break down the basement membrane allowing cancer cells to metastasize and play an important role in the tumor microenvironment. MMPs can also activate certain cytokines, growth factors, and chemokines post-translationally...
June 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30197876/new-light-on-the-pancreatic-cyst-conundrum
#6
Nathan A Berger
No abstract text is available yet for this article.
June 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30159229/circular-rnas-and-competing-endogenous-rna-cerna-networks
#7
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs (circRNAs) across a variety of cell types. Demonstration of cell type specificity, regulated expression, and conservation between species all suggest that circRNAs have functional importance. Especially, investigators have begun focusing on the possibility that circRNAs operate as part of competing endogenous RNA (ceRNA) regulatory networks that are proposed to play critical roles in normal development and in pathologic conditions like cancer...
June 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30283731/lessons-learned-from-rindopepimut-treatment-in-patients-with-egfrviii-expressing-glioblastoma
#8
David C Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L Lauing, Sebastian D Otto-Meyer, Rimas V Lukas, Derek A Wainwright
No abstract text is available yet for this article.
April 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30123739/hypofractionated-whole-breast-irradiation-is-cost-effective-but-is-that-enough-to-change-practice
#9
Apar Gupta, Nisha Ohri, Bruce G Haffty
No abstract text is available yet for this article.
April 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30112292/disulfiram-combats-cancer-via-crippling-valosin-containing-protein-p97-segregase-adaptor-npl4
#10
COMMENT
Nan Ding, Qianzheng Zhu
No abstract text is available yet for this article.
April 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30148073/exosomal-lncrnas-as-new-players-in-cell-to-cell-communication
#11
Mihnea Dragomir, Baoqing Chen, George A Calin
Neoplastic cells use various intercellular communication mechanisms in order to adapt to the local microenvironment, manipulate the immune system, and facilitate metastasis. Exosomes release is a new mechanism of cell-to-cell communication. These nanovesicles enclose various types of molecules including lipids, proteins, DNA, messenger RNA (mRNA) and non-coding RNAs [microRNA and long non-coding RNA (lncRNA)]. lncRNAs are over 200 nt long transcripts, that exhibit no coding potential, but are crucial regulators of physiological processes and are deregulated in cancer...
March 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30211018/multiscale-modeling-of-glioblastoma
#12
Huaming Yan, Mónica Romero-López, Lesly I Benitez, Kaijun Di, Hermann B Frieboes, Christopher C W Hughes, Daniela A Bota, John S Lowengrub
No abstract text is available yet for this article.
February 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30175050/smooth-sailing-for-immunotherapy-for-unresectable-stage-iii-non-small-cell-lung-cancer-the-pacific-study
#13
Melin J Khandekar, Rakesh Jain
No abstract text is available yet for this article.
February 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30148072/crispr-based-genetic-interaction-maps-inform-therapeutic-strategies-in-cancer
#14
Poornima Ramkumar, Martin Kampmann
No abstract text is available yet for this article.
February 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/29863174/cost-effectiveness-in-managing-skeletal-related-events-in-breast-cancer-a-strategy-of-less-intense-dosing-schedule-of-bone-modifying-agents
#15
COMMENT
Sri Harsha Tella, Anuhya Kommalapati, Ryan K Singhi
No abstract text is available yet for this article.
February 2018: Translational Cancer Research
https://www.readbyqxmd.com/read/30197875/multifactorial-regulators-of-tumor-programmed-death-ligand-1-pd-l1-response
#16
R Dixon Dorand, Agne Petrosiute, Alex Y Huang
No abstract text is available yet for this article.
December 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/30148071/tic10-onc201-a-potential-therapeutic-in-glioblastoma
#17
COMMENT
Georg Karpel-Massler, Markus D Siegelin
No abstract text is available yet for this article.
December 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/30214854/when-better-still-might-not-be-good-enough
#18
COMMENT
Waldemar Debinski
No abstract text is available yet for this article.
October 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/30175049/onc201-a-new-treatment-option-being-tested-clinically-for-recurrent-glioblastoma
#19
COMMENT
Marie D Ralff, Amriti R Lulla, Jessica Wagner, Wafik S El-Deiry
Glioblastoma is an aggressive central nervous system tumor with a 5-year-survival rate of less than 10%. Patients diagnosed with the disease are treated with surgery, radiation and temozolomide chemotherapy. Despite survival benefits, patients eventually relapse. There is a need for new treatments with improved efficacy. Imipridone ONC201 is a small molecule originally identified as a TNF-related apoptosis inducing ligand (TRAIL)-inducing compound. ONC201 has the unique ability to induce expression of both pro-death ligand TRAIL and its receptor DR5 through engagement of the cellular integrated stress response (ISR) pathway...
October 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/29104858/idh-mutational-status-and-the-immune-system-in-gliomas-a-tale-of-two-tumors
#20
Bryan D Choi, William T Curry
No abstract text is available yet for this article.
October 2017: Translational Cancer Research
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