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Translational Cancer Research

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https://www.readbyqxmd.com/read/28868241/targeting-cancer-with-tumor-specific-therapeutic-strategies-metabolic-reprogramming-beyond-the-warburg-effect
#1
COMMENT
Paul Grippo, Ajay V Maker
No abstract text is available yet for this article.
May 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28944168/normalizing-tumoral-vessels-to-treat-cancer-an-out-of-the-box-strategy-involving-tie2-pathway
#2
Juan Fueyo, Mohammad B Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
No abstract text is available yet for this article.
March 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28690978/exploring-gold-nanoparticle-interactions-with-proteins-and-the-tumor-microenvironment-in-biological-systems
#3
Li Tian, Ashley Chang, Marites P Melancon
No abstract text is available yet for this article.
March 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28966917/advances-on-immunotherapy-in-genitourinary-and-renal-cell-carcinoma
#4
Gregory P Botta, Eric Granowicz, Carrie Costantini
Genitourinary (GU) cancers are a group of epithelial malignancies associated with the organs involved in the excretion of urine. Renal cell, urothelial, and prostatic carcinoma are the overwhelming subtypes diagnosed by oncologists. Each of these was traditionally treated surgically when local and non-invasive. When these carcinomas spread, invade, or metastasize, surgical control lacks in efficacy. Chemotherapeutic regimens have been implemented for decades and have increased overall survival but many patients progress...
February 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28955654/the-role-of-novel-immunotherapies-in-non-hodgkin-lymphoma
#5
Allyson Pishko, Sunita D Nasta
Immunotherapy is an evolving modality in the treatment of non-Hodgkin lymphoma. Vaccinations with patient-specific tumor-derived antigens have been developed to strengthen immune response to tumor. The success of rituximab, a monoclonal antibody for CD20 on malignant B-cells, fueled further immunotherapy research. The power of the immune system to fight hematologic malignancies is seen in allogeneic stem cell transplant, where donor T cells attack residual malignant cells in the recipient. Now, three innovative therapeutic immunotherapy classes (I) adoptive cellular therapy; (II) immune-checkpoint inhibitors; and (III) novel antibody therapies show promising results in non-Hodgkin lymphoma...
February 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28680831/a-crowded-but-still-varied-space-brigatinib-in-anaplastic-lymphoma-kinase-rearranged-non-small-cell-lung-cancer
#6
COMMENT
Sawsan Rashdan, David E Gerber
No abstract text is available yet for this article.
February 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28529909/molecular-heterogeneity-of-localized-prostate-cancer-more-different-than-alike
#7
Jeffrey J Tosoian, Emmanuel S Antonarakis
No abstract text is available yet for this article.
February 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28503409/taming-immune-suppressor-application-of-myeloid-derived-suppressor-cells-in-anti-cancer-gene-therapy
#8
Bhagelu R Achyut, Ali S Arbab
No abstract text is available yet for this article.
February 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28966916/the-igf-1r-akt-pathway-determines-cell-fate-in-response-to-p53
#9
Lei Duan, Carl G Maki
p53 that is activated in response to DNA-damaging stress can induce apoptosis or either transient or permanent cell cycle arrests. Apoptosis and permanent cell cycle arrest (senescence) are bona-fide tumor suppressor mechanisms through which p53 inhibits cancer cell survival. In contrast, transient cell cycle arrests induced by p53 can increase survival by allowing cells time to repair their DNA before proceeding with cell division. Mechanisms that control the choice of response to p53 (apoptosis vs arrest) are not fully understood...
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28944167/regulation-of-cytotoxic-t-cell-responses-by-p53-in-cancer
#10
Mitchell W Braun, Tomoo Iwakuma
An intriguing aspect of the tumor suppressor p53 is its ability to communicate to the adaptive immune system and control the cytotoxic T-lymphocyte (CTL) response to cancer cells. Wild-type p53 (wtp53) communicates with CTLs through proteins involved in the major histocompatibility complex (MHC) class I antigen presentation pathway [e.g., transporter associated with antigen processing 1 (TAP1) and endoplasmic reticulum amino peptidase 1 (ERAP1)], the apoptosis signal receptor Fas/APO-1, and the inhibitory immune-checkpoint programmed death-ligand 1 (PD-L1)...
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28819587/empiric-h-pylori-therapy-10-day-concomitant-bismuth-quadruple-or-14-day-triple-therapy-none-is-best
#11
COMMENT
Yoshio Yamaoka, David Y Graham
No abstract text is available yet for this article.
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28794999/modulation-of-the-p53-family-network-by-rna-binding-proteins
#12
Chris Lucchesi, Jin Zhang, Xinbin Chen
Since its discovery more than three decades ago, tumor suppressor p53 has been shown to play pivotal roles in both maintaining genomic integrity and tumor suppression. p53 functions as a transcription factor responding to a multitude of cellular stressors, regulating the transcription of many genes involved in cell-cycle arrest, senescence, autophagy, and apoptosis. Extensive work has revealed that p53 is one of the most commonly mutated tumor suppressor genes. The last three decades have demonstrated that p53 activity is controlled through transcriptional regulation and posttranslational modifications...
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28690977/regulation-of-the-mdm2-p53-signaling-axis-in-the-dna-damage-response-and-tumorigenesis
#13
Michael I Carr, Stephen N Jones
The p53 tumor suppressor acts as a guardian of the genome in mammalian cells undergoing DNA double strand breaks induced by a various forms of cell stress, including inappropriate growth signals or ionizing radiation. Following damage, p53 protein levels become greatly elevated in cells and p53 functions primarily as a transcription factor to regulate the expression a wide variety of genes that coordinate this DNA damage response. In cells undergoing high amounts of DNA damage, p53 can promote apoptosis, whereas in cells undergoing less damage, p53 promotes senescence or transient cell growth arrest and the expression of genes involved in DNA repair, depending upon the cell type and level of damage...
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28239565/pd-l1-is-a-diverse-molecule-regulating-both-tumor-intrinsic-signaling-and-adaptive-immunosuppression
#14
Kim A Brogden, Shireen Vali, Taher Abbasi
No abstract text is available yet for this article.
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28936397/targeted-attack-mechanisms-by-which-ovarian-cancers-suppress-the-immune-system
#15
COMMENT
Irina V Tiper, Tonya J Webb
No abstract text is available yet for this article.
November 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28868240/jak3-mediated-phosphorylation-of-ezh2-a-novel-mechanism-of-non-canonical-ezh2-activation-and-oncogenic-function
#16
Theodoros Karantanos, Vassiliki A Boussiotis
No abstract text is available yet for this article.
November 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28523239/cisplatin-etoposide-and-irinotecan-for-relapsed-small-cell-lung-cancer
#17
COMMENT
Angel Qin, Gregory P Kalemkerian
No abstract text is available yet for this article.
November 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28983463/the-liquid-biopsy-in-non-small-cell-lung-cancer-not-quite-ready-for-prime-time-use
#18
Angel Qin, Nithya Ramnath
No abstract text is available yet for this article.
October 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28664150/coexpression-and-expression-quantitative-trait-loci-analyses-of-the-angiogenesis-gene-gene-interaction-network-in-prostate-cancer
#19
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y Ann Chen, Jong Y Park
BACKGROUND: Prostate cancer (PCa) shows a substantial clinical heterogeneity. The existing risk classification for PCa prognosis based on clinical factors is not sufficient. Although some biomarkers for PCa aggressiveness have been identified, their underlying functional mechanisms are still unclear. We previously reported a gene-gene interaction network associated with PCa aggressiveness based on single nucleotide polymorphism (SNP)-SNP interactions in the angiogenesis pathway. The goal of this study is to investigate potential functional evidence of the involvement of the genes in this gene-gene interaction network...
October 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28649559/helicobacter-pylori-vacuolating-cytotoxin-and-gastric-cancer-risk-reconsidered
#20
COMMENT
Muhammad Miftahussurur, Yoshio Yamaoka, David Y Graham
No abstract text is available yet for this article.
September 2016: Translational Cancer Research
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