journal
Journals American Journal of Neurodegen...

American Journal of Neurodegenerative Disease

https://read.qxmd.com/read/34712518/gabapentin-versus-pregabalin-for-management-of-chronic-inflammatory-demyelinating-polyradiculoneuropathy
#21
JOURNAL ARTICLE
Moulood Rayani, Behnaz Ansari, Sajad Asadi Boroujeni, Hossein Abdollahi Veshnavei, Keivan Basiri
INTRODUCTION: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic autoimmune demyelinating peripheral neuropathy that leads to symmetrical muscular weakness, sensory deficit, hyporeflexia, chronic fatigue, and impaired quality of life (QoL). The current study aims to investigate the effects of gabapentin versus pregabalin on pain, sleep disturbances, and QoL in CIDP patients. METHODS: This clinical trial was conducted on 40 patients diagnosed with CIDP randomly allocated to treatment with 100-500 mg gabapentin (n=20) or 50-300 mg pregabalin (n=20) both co-medicated with 37...
2021: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/34712517/link-of-neurocognitive-deficit-to-impaired-cardiovagal-modulation-in-prehypertensives-is-comparable-to-newly-diagnosed-hypertensives-in-young-indian-population
#22
JOURNAL ARTICLE
Gopal Krushna Pal, Thiruchengodu Ammaiyappan Subathra, Yerrabelli Dhanalakshmi, Pravati Pal, Manoharan Renugasundari, Nivedita Nanda
BACKGROUND: Hypertension has been reported to cause impaired cardiovagal modulation and a wide variety of cognitive loss. However, the link cardiovagal modulation to neurocognitive impairment has not been studied yet. The present study has compared the link cardiovagal modulation to neurocognitive impairment between prehypertension and newly diagnosed hypertension in young adults. METHODS: One hundred forty-seven subjects (42 normotensives, 54 prehypertensives and 51 newly diagnosed hypertensives) aged between 18-44 years were included in this case-control study...
2021: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/34712516/parsonage-turner-syndrome-a-firsthand-experience-of-an-uncommon-malady
#23
JOURNAL ARTICLE
Vinod P Jerath, Vikram K Mahajan
Parsonage Turner Syndrome (syn. idiopathic brachial plexopathy, neurologic amyotrophy) is a rare syndrome of poorly understood etiology with a reported incidence of 1.64 in 1 lakh persons per year. It affects men more often than women with a highest incidence in the third and seventh decades of life. Its pathophysiology is obscure and the syndrome has been reported in the postoperative, post infectious and recent viral illness, and post-vaccination settings. Trauma from manipulation of tissues and various positioning techniques used to facilitate surgical techniques, or immune-mediated inflammation remains the most common associated risk factor...
2021: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/34327050/microrna-expression-changes-in-parkinson-s-disease-pd-patients-leukocytes-prior-to-and-following-deep-brain-stimulation-dbs
#24
JOURNAL ARTICLE
Soreq Lilach, Bergman Hagai, Israel Zvi, Soreq Hermona, Mohamed Wael
The second most prevalent neurodegenerative disorder worldwide in the elderly is Parkinson's disease (PD). It is a major risk factor for aging. Objectives: Currently the involvement of miRNAs in the disease is mainly unclear. Additionally, the disease aetiology is complex and there are no available disease-modifying medications. Therefore, more evidence is required concerning its pathogenesis and developing new treatment modalities. Methods: Here, we studied the expression profiles of about 900 miRNAs in PD patients prior to and following deep brain stimulation (DBS) both on and following 1 hour off electrical stimulation and as compared with age and gender matched healthy control (HC) donor samples, using Affymetrix miRNA microarrays...
2021: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/34084662/therapeutic-potential-of-allium-sativum-against-the-a%C3%AE-1-40-induced-oxidative-stress-and-mitochondrial-dysfunction-in-the-wistar-rats
#25
JOURNAL ARTICLE
Neetu Saini, Monika Kadian, Alka Khera, Aanchal Aggarwal, Anil Kumar
From the early stages of any neurodegenerative-disease mitochondrial functionality has been mortally extricated, though the exact timeline of these events is still unclear, it is likely to represent a progressive neurons-decline and cognitive-functions. Hence strategies suggested by herbal extract to restore mitochondrial functions may be a remedial approach to chronic neurodegenerative disorder like Alzheimer's disease (AD). This research was designed to evaluate if Aβ1-40 induced oxidative stress and mitochondrial dysfunction could be inhibited by Allium Sativum (AS) supplementation...
2021: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/33815964/neurodegeneration-and-axonal-mrna-transportation
#26
REVIEW
Mohammad Mofatteh
The prevalence of neurodegenerative diseases is accelerating in rapidly aging global population. Novel and effective diagnostic and therapeutic methods are required to tackle the global issue of neurodegeneration in the future. A better understanding of the potential molecular mechanism causing neurodegeneration can shed light on dysfunctional processes in diseased neurons, which can pave the way to design and synthesize novel targets for early diagnosis during the asymptomatic phase of the disease. Abnormal protein aggregation is a hallmark of neurodegenerative diseases which can hamper transportation of cargoes into axons...
2021: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/33489482/outcome-of-patients-with-lumbar-spinal-canal-stenosis-due-to-discogenic-under-percutaneous-laser-disc-decompression
#27
JOURNAL ARTICLE
Ahmad Shekarchizadeh, Ali Mohammadi-Moghadam, Majid Rezvani, Peyman Rahmani, Nourallah Eshraghi, Keyvan Ghadimi
BACKGROUND: The Percutaneous laser disc decompression (PLDD) method was first described by Daniel Choy in Australia in 1987. Therefore, in this study, we examined the clinical signs and symptoms of patients with spinal canal stenosis due to disc protrusion after PLDD surgery. METHODS: In this clinical trial study, 43 patients with spinal canal stenosis due to lumbar disks who referred to Kashani and Zahra Marzieh educational hospitals from 2006 to 2016 were entered the study...
2020: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/30906671/translational-inhibition-of-%C3%AE-synuclein-by-posiphen-normalizes-distal-colon-motility-in-transgenic-parkinson-mice
#28
JOURNAL ARTICLE
Yien-Ming Kuo, Ejike Innocent Nwankwo, Robert L Nussbaum, Jack Rogers, Maria L Maccecchini
Parkinson disease (PD) is a neurodegenerative disease with motor as well as non-motor symptoms, including gastrointestinal dysfunction. In humans, these precede the motor symptoms by decades. Previously developed and characterized transgenic mice expressing the mutant human α-synuclein gene ( SNCA ) (either A53T or A30P), but not the endogenous mouse Snca , serve as models for familial PD. These animals demonstrate both robust abnormalities in enteric nervous system (ENS) function as well as synuclein-immunoreactive aggregates in ENS ganglia by 3 months of age, recapitulating early gastrointestinal abnormalities seen before the gait impairment characteristics of human and murine PD...
2019: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/29531866/overexpression-of-ter94-drosophila-vcp-improves-motor-neuron-degeneration-induced-by-knockdown-of-tbph-drosophila-tdp-43
#29
JOURNAL ARTICLE
Yukie Kushimura, Takahiko Tokuda, Yumiko Azuma, Itaru Yamamoto, Ikuko Mizuta, Toshiki Mizuno, Masanori Nakagawa, Morio Ueyama, Yoshitaka Nagai, Hideki Yoshida, Masamitsu Yamaguchi
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease characterized by the motor neuron degeneration that eventually leads to complete paralysis and death within 2-5 years after disease onset. One of the major pathological hallmark of ALS is abnormal accumulation of inclusions containing TAR DNA-binding protein-43 (TDP-43). TDP-43 is normally found in the nucleus, but in ALS, it localizes in the cytoplasm as inclusions as well as in the nucleus. Loss of nuclear TDP-43 functions likely contributes to neurodegeneration...
2018: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/29531865/the-protective-effects-of-crocin-in-the-management-of-neurodegenerative-diseases-a-review
#30
REVIEW
Tahereh Farkhondeh, Saeed Samarghandian, Hanieh Shaterzadeh Yazdi, Fariborz Samini
Flavonoids have been used in traditional medicine to promote human health. Crocin has been proposed to be effective in the management of the various diseases including the neurodegenerative diseases. Antiepileptic and anti-Alzheimer effects of crocin have also been indicated. The efficacy of crocis in the treatment of cerebral ischemia and traumatic brain injury was also confirmed by using animal models. Crocin treatment increased dopamine levels in the brain of experimental model of Parkinson's disease. In addition, crocin modulates the opioid system to decrease the withdrawal syndrome...
2018: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/28804692/one-case-with-dexmedetomidine-induced-stuporous-state-in-epileptic-patient-undergoing-abdominal-surgery
#31
Dong-Ji Han, Zhi-Gang He, Zhi-Qiang Zhou, Li Feng, Cheng Liu, Yan Xiang, Hong-Bing Xiang
A 56-year-old epileptic patient underwent right hemicolectomy and cholecystectomy surgery under general endotracheal anesthesia. Anesthesia was maintained with sevoflurane, and sufentanil, rocuronium, and dexmedetomidine infusions. After the operation and confirmation of neuromuscular recovery, the patient woke from anesthesia within 15 min and successfully extubated. After the vital signs of patient were stable, the patient was transported to post anesthesia care unit (PACU). 6 h after the surgery, he fell into a stuporous state for lasting 14 h and EEG showed no epileptiform discharges...
2017: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/28533943/etiology-and-treatment-of-amyotrophic-lateral-sclerosis
#32
JOURNAL ARTICLE
Hernando Rafael, Juan Oscar David, Antonio Santiago Vilca
BACKGROUND: To date all researchers conclude that the etiology of Amyotrophic lateral sclerosis (ALS) is not known. On the contrary, since August 2009, we believe that disease is of ischemic origin in the anterior surface of the medulla oblongata. MATERIAL AND METHOD: We present our surgical experience into 45 patients with ALS (bulbar form in 36 cases and spinal form in 9). Preoperative MRI scans revealed microinfarcts in the medulla oblongata and/or cervical cord...
2017: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/28078193/metabolic-inflammatory-and-microvascular-determinants-of-white-matter-disease-and-cognitive-decline
#33
REVIEW
Maggie Wang, Jennifer E Norman, Vivek J Srinivasan, John C Rutledge
White Matter Disease is increasingly being recognized as an important cause of cognitive decline and dementia. Various investigations have linked chronic diet-related conditions to the development of white matter lesions, which appear as white matter hyperintensities on T2-weighted magnetic resonance imaging (MRI) scans of the brain. Thus, it can be postulated that the metabolic, inflammatory, and microvascular changes accompanying a western diet, hyperlipidemia, hypertension, and diabetes mellitus type II (DMII) are potential mediators in the development and progression of white matter disease, which in turn contributes to the development and progression of cognitive decline...
2016: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/27725918/chemical-and-neuropathological-analyses-of-an-alzheimer-s-disease-patient-treated-with-solanezumab
#34
JOURNAL ARTICLE
Alex E Roher, Chera L Maarouf, Tyler A Kokjohn, Christine Belden, Geidy Serrano, Marwan S Sabbagh, Thomas G Beach
INTRODUCTION: Based on the amyloid cascade hypothesis of Alzheimer's disease (AD) pathogenesis, a series of clinical trials involving immunotherapies have been undertaken including infusion with the IgG1 monoclonal anti-Aβ antibody solanezumab directed against the middle of the soluble Aβ peptide. In this report, we give an account of the clinical history, psychometric testing, gross and microscopic neuropathology as well as immunochemical quantitation of soluble and insoluble Aβ peptides and other proteins of interest related to AD pathophysiology in a patient treated with solanezumab...
2016: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/27508110/omental-transplantation-in-a-patient-with-mild-als
#35
Hernando Rafael
To demonstrate that amyotrophic lateral sclerosis (ALS) is not a neurodegenerative disease. The patient, a 33-year-old man began with symptoms of the bulbar form of ALS, characterized by burning pain in both feet during two months and then, he presented right crural monoparesis, fasciculations, slight dysarthria and he walked with help of orthopedic devices. A preoperative MRI scans showed atherosclerosis at the V4 segment of the left vertebral artery. On May 2012, he received an omental transplantation on the anterior, left lateral and posterior surface of the medulla oblongata...
2016: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/27508109/fundamental-role-of-pan-inflammation-and-oxidative-nitrosative-pathways-in-neuropathogenesis-of-alzheimer-s-disease-retraction
#36
(no author information available yet)
[This retracts the article on p. 1 in vol. 5, PMID: 27073740.].
2016: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/27335704/effect-of-fish-oil-on-glutathione-redox-system-in-multiple-sclerosis
#37
JOURNAL ARTICLE
Tania E Sorto-Gomez, Genaro G Ortiz, Fermín P Pacheco-Moises, Erandis D Torres-Sanchez, Viridiana Ramirez-Ramirez, Miguel A Macias-Islas, Alfredo Celis de la Rosa, Irma E Velázquez-Brizuela
UNLABELLED: Multiple sclerosis (MS) is a chronic, inflammatory and autoimmune disease of the central nervous system. Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme activities are implicated in the induction and progression of MS. Evidence suggests that Omega-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory, antioxidant and neuroprotective effects. The aim of the present work was to evaluate the effect of fish oil on the activity of glutathione reductase (GR), content of reduced and oxidized glutathione, and GSH/GSSG ratio in MS...
2016: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/27335703/ganoderma-lucidum-polysaccharides-protect-against-mpp-and-rotenone-induced-apoptosis-in-primary-dopaminergic-cell-cultures-through-inhibiting-oxidative-stress
#38
JOURNAL ARTICLE
Shan-Shan Guo, Xiao-Lan Cui, Wolf-Dieter Rausch
Oxidative stress plays a pivotal role in the progressive neurodegeneration in Parkinson's disease (PD) which is responsible for disabling motor abnormalities in more than 6.5 million people worldwide. Polysaccharides are the main active constituents from Ganoderma lucidum which is characterized with anti-oxidant, antitumor and immunostimulant properties. In the present study, primary dopaminergic cell cultures prepared from embryonic mouse mesencephala were used to investigate the neuroprotective effects and the potential mechanisms of Ganoderma lucidum polysaccharides (GLP) on the degeneration of dopaminergic neurons induced by the neurotoxins methyl-4-phenylpyridine (MPP(+)) and rotenone...
2016: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/27335702/fundamental-role-of-pan-inflammation-and-oxidative-nitrosative-pathways-in-neuropathogenesis-of-alzheimer-s-disease-in-focal-cerebral-ischemic-rats
#39
REVIEW
Mak Adam Daulatzai
Alzheimer's disease (AD) is a chronic progressive neurodegenerative condition of the brain, and it is the most common cause of dementia. Several neurobiological etiologies of AD are described in the literature. These include vascular, infectious, toxic, nutritional, metabolic, and inflammatory. However, these heterogeneous etiologies have a common denominator - viz. Inflammation and oxidative stress. Lipopolysaccharide (LPS) elevates the synthesis of proinflammatory cytokines and chemokines; chronically, together they trigger various pathological responses in the periphery and the CNS including dysfunctional memory consolidation and memory decline...
2016: American Journal of Neurodegenerative Disease
https://read.qxmd.com/read/27073747/the-presenilin-1-p-gly206ala-mutation-is-a-frequent-cause-of-early-onset-alzheimer-s-disease-in-hispanics-in-florida
#40
JOURNAL ARTICLE
Thomas A Ravenscroft, Cyril Pottier, Melissa E Murray, Matt Baker, Elizabeth Christopher, Denise Levitch, Patricia H Brown, Warren Barker, Ranjan Duara, Maria Greig-Custo, Ana Betancourt, Mara English, Xiaoyan Sun, Nilüfer Ertekin-Taner, Neill R Graff-Radford, Dennis W Dickson, Rosa Rademakers
Mutations in the gene encoding the presenilin-1 protein (PSEN1) were first discovered to cause Alzheimer's disease (AD) 20 years ago. Since then more than 200 different pathogenic mutations have been reported, including a p.Gly206Ala founder mutation in the Hispanic population. Here we report mutation analysis of known AD genes in a cohort of 27 early-onset (age of onset ≤65, age of death ≤70) Hispanic patients ascertained in Florida. The PSEN1 p.Gly206Ala mutation was identified in 13 out of 27 patients (48...
2016: American Journal of Neurodegenerative Disease
journal
journal
44085
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.