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American Journal of Neurodegenerative Disease

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https://www.readbyqxmd.com/read/27725918/chemical-and-neuropathological-analyses-of-an-alzheimer-s-disease-patient-treated-with-solanezumab
#1
Alex E Roher, Chera L Maarouf, Tyler A Kokjohn, Christine Belden, Geidy Serrano, Marwan S Sabbagh, Thomas G Beach
INTRODUCTION: Based on the amyloid cascade hypothesis of Alzheimer's disease (AD) pathogenesis, a series of clinical trials involving immunotherapies have been undertaken including infusion with the IgG1 monoclonal anti-Aβ antibody solanezumab directed against the middle of the soluble Aβ peptide. In this report, we give an account of the clinical history, psychometric testing, gross and microscopic neuropathology as well as immunochemical quantitation of soluble and insoluble Aβ peptides and other proteins of interest related to AD pathophysiology in a patient treated with solanezumab...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27508110/omental-transplantation-in-a-patient-with-mild-als
#2
Hernando Rafael
To demonstrate that amyotrophic lateral sclerosis (ALS) is not a neurodegenerative disease. The patient, a 33-year-old man began with symptoms of the bulbar form of ALS, characterized by burning pain in both feet during two months and then, he presented right crural monoparesis, fasciculations, slight dysarthria and he walked with help of orthopedic devices. A preoperative MRI scans showed atherosclerosis at the V4 segment of the left vertebral artery. On May 2012, he received an omental transplantation on the anterior, left lateral and posterior surface of the medulla oblongata...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27508109/fundamental-role-of-pan-inflammation-and-oxidative-nitrosative-pathways-in-neuropathogenesis-of-alzheimer-s-disease-retraction
#3
(no author information available yet)
[This retracts the article on p. 1 in vol. 5, PMID: 27073740.].
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27335704/effect-of-fish-oil-on-glutathione-redox-system-in-multiple-sclerosis
#4
Tania E Sorto-Gomez, Genaro G Ortiz, Fermín P Pacheco-Moises, Erandis D Torres-Sanchez, Viridiana Ramirez-Ramirez, Miguel A Macias-Islas, Alfredo Celis de la Rosa, Irma E Velázquez-Brizuela
UNLABELLED: Multiple sclerosis (MS) is a chronic, inflammatory and autoimmune disease of the central nervous system. Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme activities are implicated in the induction and progression of MS. Evidence suggests that Omega-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory, antioxidant and neuroprotective effects. The aim of the present work was to evaluate the effect of fish oil on the activity of glutathione reductase (GR), content of reduced and oxidized glutathione, and GSH/GSSG ratio in MS...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27335703/ganoderma-lucidum-polysaccharides-protect-against-mpp-and-rotenone-induced-apoptosis-in-primary-dopaminergic-cell-cultures-through-inhibiting-oxidative-stress
#5
Shan-Shan Guo, Xiao-Lan Cui, Wolf-Dieter Rausch
Oxidative stress plays a pivotal role in the progressive neurodegeneration in Parkinson's disease (PD) which is responsible for disabling motor abnormalities in more than 6.5 million people worldwide. Polysaccharides are the main active constituents from Ganoderma lucidum which is characterized with anti-oxidant, antitumor and immunostimulant properties. In the present study, primary dopaminergic cell cultures prepared from embryonic mouse mesencephala were used to investigate the neuroprotective effects and the potential mechanisms of Ganoderma lucidum polysaccharides (GLP) on the degeneration of dopaminergic neurons induced by the neurotoxins methyl-4-phenylpyridine (MPP(+)) and rotenone...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27335702/fundamental-role-of-pan-inflammation-and-oxidative-nitrosative-pathways-in-neuropathogenesis-of-alzheimer-s-disease-in-focal-cerebral-ischemic-rats
#6
REVIEW
Mak Adam Daulatzai
Alzheimer's disease (AD) is a chronic progressive neurodegenerative condition of the brain, and it is the most common cause of dementia. Several neurobiological etiologies of AD are described in the literature. These include vascular, infectious, toxic, nutritional, metabolic, and inflammatory. However, these heterogeneous etiologies have a common denominator - viz. Inflammation and oxidative stress. Lipopolysaccharide (LPS) elevates the synthesis of proinflammatory cytokines and chemokines; chronically, together they trigger various pathological responses in the periphery and the CNS including dysfunctional memory consolidation and memory decline...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073747/the-presenilin-1-p-gly206ala-mutation-is-a-frequent-cause-of-early-onset-alzheimer-s-disease-in-hispanics-in-florida
#7
Thomas A Ravenscroft, Cyril Pottier, Melissa E Murray, Matt Baker, Elizabeth Christopher, Denise Levitch, Patricia H Brown, Warren Barker, Ranjan Duara, Maria Greig-Custo, Ana Betancourt, Mara English, Xiaoyan Sun, Nilüfer Ertekin-Taner, Neill R Graff-Radford, Dennis W Dickson, Rosa Rademakers
Mutations in the gene encoding the presenilin-1 protein (PSEN1) were first discovered to cause Alzheimer's disease (AD) 20 years ago. Since then more than 200 different pathogenic mutations have been reported, including a p.Gly206Ala founder mutation in the Hispanic population. Here we report mutation analysis of known AD genes in a cohort of 27 early-onset (age of onset ≤65, age of death ≤70) Hispanic patients ascertained in Florida. The PSEN1 p.Gly206Ala mutation was identified in 13 out of 27 patients (48...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073746/association-study-between-the-dnmt3a-448a-g-polymorphism-and-risk-of-alzheimer-s-disease-in-caucasians-of-italian-origin
#8
Pierpaola Tannorella, Andrea Stoccoro, Gloria Tognoni, Ubaldo Bonuccelli, Lucia Migliore, Fabio Coppedè
Increasing evidence points to an epigenetic contribution in Alzheimer's disease (AD) pathogenesis. In this regard, variants and polymorphisms of DNA methyltransferase genes (DNMTs) are being investigated for their contribution to cognitive decline and dementia, but results are still scarce or controversial. In the present study we genotyped 710 Caucasian subjects of Italian descent, including 320 late-onset AD (LOAD) patients, 70 individuals with amnestic Mild Cognitive Impairment (MCI), and 320 matched healthy controls, for the presence of a functional DNMT3A -448A>G (rs1550117) polymorphism, searching for association with disease risk...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073745/molecular-events-linking-cholesterol-to-alzheimer-s-disease-and-inclusion-body-myositis-in-a-rabbit-model
#9
Qing Yan Liu, Roger Koukiekolo, Dong Ling Zhang, Brandon Smith, Dao Ly, Joy X Lei, Othman Ghribi
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by cognitive impairment and dementia, resulting from progressive synaptic dysfunction, loss and neuronal cell death. Inclusion body myositis (IBM) is a skeletal muscle degenerative disease, displaying progressive proximal and distal muscle weakness, in association with muscle fiber atrophy, degeneration and death. Studies have shown that the late onset version of AD (LOAD) and sporadic IBM (sIBM) in muscle share many pathological features, including the presence of extracellular plaques of β-amyloid peptides and intracellular tangles of hyperphosphorylated tau proteins...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073744/pyruvate-blocks-blood-brain-barrier-disruption-lymphocyte-infiltration-and-immune-response-in-excitotoxic-brain-injury
#10
Jae K Ryu, James G McLarnon
The effects of pyruvate, the end metabolite of glycolysis, on blood-brain barrier (BBB) impairment and immune reactivity were examined in the quinolinic acid (QA)-injected rat striatum. Extensive disruption of BBB was observed at 7 d post QA-injection as demonstrated by increased immunohistochemical staining using antibody against immunoglobulin G (IgG). Animals receiving pyruvate administration (500 mg/kg) with QA-injection exhibited reduced lgG immunoreactivity (by 45%) relative to QA alone. QA intrastriatal injection also resulted in marked increases in the number of infiltrating T-lymphocytes (by 70-fold) and expression of major histocompatibility complex (MHC-class II) (by 45-fold) relative to unlesioned control...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073743/ebi-a-drosophila-homologue-of-tbl1-regulates-the-balance-between-cellular-defense-responses-and-neuronal-survival
#11
Young-Mi Lim, Leo Tsuda
Transducin β-like 1 (TBL1), a transcriptional co-repressor complex, is a causative factor for late-onset hearing impairments. Transcriptional co-repressor complexes play pivotal roles in gene expression by making a complex with divergent transcription factors. However, it remained to be clarified how co-repressor complex regulates cellular survival. We herein demonstrated that ebi, a Drosophila homologue of TBL1, suppressed photoreceptor cell degeneration in the presence of excessive innate immune signaling...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073742/ginsenoside-rd-and-ginsenoside-re-offer-neuroprotection-in-a-novel-model-of-parkinson-s-disease
#12
Xinmu Zhang, Yingzi Wang, Cheng Ma, Yan Yan, Yang Yang, Xin Wang, Wolf-Dieter Rausch
Ginsenosides are the main active constituents of Panax ginseng. Ginsenoside Re is one of the major ginsenosides; whereas hydrolysis products such as Rd appear to have higher biological activity though are present in smaller amounts. Ginsenosides, from their early use in folk medicine to modern studies, appear to exert beneficial actions against aging and even neurodegenerative disorders. Parkinson's disease is a progressive neurodegenerative movement disorder characterized by a profound loss of midbrain dopamine neurons in the substantia nigra pars compacta...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073741/repurposing-psychiatric-medicines-to-target-activated-microglia-in-anxious-mild-cognitive-impairment-and-early-parkinson-s-disease
#13
REVIEW
Edward C Lauterbach
Anxiety is common in the Mild Cognitive Impairment (MCI) stage of Alzheimer's disease (AD) and the pre-motor stages of Parkinson's disease (PD). A concomitant and possible cause of this anxiety is microglial activation, also considered a key promoter of neurodegeneration in MCI and early PD via inflammatory mechanisms and the generation of degenerative proinflammatory cytokines. Psychiatric disorders, prevalent in AD and PD, are often treated with psychiatric drugs (psychotropics), raising the question of whether psychotropics might therapeutically affect microglial activation, MCI, and PD...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27073740/fundamental-role-of-pan-inflammation-and-oxidative-nitrosative-pathways-in-neuropathogenesis-of-alzheimer-s-disease
#14
REVIEW
Mak Adam Daulatzai
Alzheimer's disease (AD) is a chronic progressive neurodegenerative condition of the brain, and it is the most common cause of dementia. Several neurobiological etiologies of AD are described in the literature. These include vascular, infectious, toxic, nutritional, metabolic, and inflammatory. However, these heterogeneous etiologies have a common denominator - viz. Inflammation and oxidative stress. Lipopolysaccharide (LPS) elevates the synthesis of proinflammatory cytokines and chemokines; chronically, together they trigger various pathological responses in the periphery and the CNS including dysfunctional memory consolidation and memory decline...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/26807344/erratum-development-appraisal-validation-and-implementation-of-a-consensus-protocol-for-the-assessment-of-cerebral-amyloid-angiopathy-in-post-mortem-brain-tissue
#15
Seth Love, Katy Chalmers, Paul Ince, Margaret Esiri, Johannes Attems, Raj Kalaria, Kurt Jellinger, Masahito Yamada, Mark McCarron, Thais Minett, Fiona Matthews, Steven Greenberg, David Mann, Patrick Gavin Kehoe
In a collaboration involving 11 groups with research interests in cerebral amyloid angiopathy (CAA), we used a two-stage process to develop and in turn validate a new consensus protocol and scoring scheme for the assessment of CAA and associated vasculopathic abnormalities in post-mortem brain tissue. Stage one used an iterative Delphi-style survey to develop the consensus protocol. The resultant scoring scheme was tested on a series of digital images and paraffin sections that were circulated blind to a number of scorers...
2015: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/26807343/transcription-factor-sp1-inhibition-memory-and-cytokines-in-a-mouse-model-of-alzheimer-s-disease
#16
Bruce A Citron, Jessica N Saykally, Chuanhai Cao, John S Dennis, Melissa Runfeldt, Gary W Arendash
Transcription factors are involved to varying extents in the health and survival of neurons in the brain and a better understanding of their roles with respect to the pathogenesis of Alzheimer's disease (AD) could lead to the development of additional treatment strategies. Sp1 is a transcription factor that responds to inflammatory signals occurring in the AD brain. It is known to regulate genes with demonstrated importance in AD, and we have previously found it upregulated in the AD brain and in brains of transgenic AD model mice...
2015: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/26807342/anti-inflammatory-therapies-of-amyotrophic-lateral-sclerosis-guided-by-immune-pathways
#17
Larry Lam, Ramesh C Halder, Dennis J Montoya, Liudmilla Rubbi, Arturo Rinaldi, Bien Sagong, Sarah Weitzman, Rachel Rubattino, Ram Raj Singh, Matteo Pellegrini, Milan Fiala
Sporadic ALS patients display heterogeneous immune pathways in peripheral blood mononuclear cells (PBMCs). We tested nine sALS patients and one unaffected identical twin of an index case by RNA-Seq of PBMCs. The inflammatory patients (n = 3) clustered into a subset with an inflammatory Th1/Th17 signature and the non-inflammatory patients (n = 7) into another subset with a B cell signature. The inflammatory subset was remarkable for granulocyte and agranulocyte diapedesis, hepatic fibrosis, roles of cytokines and metalloproteases...
2015: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/26389016/atrophy-and-lower-regional-perfusion-of-temporo-parietal-brain-areas-are-correlated-with-impairment-in-memory-performances-and-increase-of-eeg-upper-alpha-power-in-prodromal-alzheimer-s-disease
#18
Vito Davide Moretti
BACKGROUND: Temporo-parietal cortex thinning is associated with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). The increase of the EEG upper/low alpha power ratio has been associated with MCI due to AD subjects and to the atrophy of temporo-parietal brain areas. Moreover, subjects with a higher alpha3/alpha2 frequency power ratio showed lower brain perfusion than in the low alpha3/alpha2 group. The two groups have significantly different hippocampal volumes and correlation with the theta frequency activity...
2015: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/26389015/omental-transplantation-for-neuroendocrinological-disorders
#19
REVIEW
Hernando Rafael
Neurosurgical evidences show that the aging process is initiated between 25 to 30 years of age, in the arcuate nucleus of the hypothalamus. Likewise, experimental and neurosurgical findings indicate that the progressive ischemia in the arcuate nucleus and adjacent nuclei are responsibles at the onset of obesity and, type 2 diabetes mellitus in adults, and essential arterial hypertension (EAH). On the contrary, an omental transplantation on the optic chiasma, carotid bifurcation and anterior perforated space can provoke rejuvenation, gradual loss of body weight, decrease or normalization of hyperglycemia and normalization of EAH; all of them, due to revascularization of the hypothalamic nuclei...
2015: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/25628968/select-small-nucleolar-rnas-in-blood-components-as-novel-biomarkers-for-improved-identification-of-comorbid-traumatic-brain-injury-and-post-traumatic-stress-disorder-in-veterans-of-the-conflicts-in-afghanistan-and-iraq
#20
Lap Ho, Gudrun Lange, Wei Zhao, Jun Wang, Robert Rooney, Divyen H Patel, Malusha M Fobler, Drew A Helmer, Gregory Elder, Michael C Shaughness, Stephen T Ahlers, Scott J Russo, Giulio Maria Pasinetti
BACKGROUND: The present study was designed to validate the ability of our recently identified set of small noncoding RNA candidate mild traumatic brain injury (mTBI) biomarkers to diagnose mTBI in the presence or absence of post-traumatic stress disorder (PTSD) comorbidity. Using qPCR, we explored the regulation of the candidate biomarkers in peripheral blood mononuclear cells (PBMC) from 58 veterans. RESULTS: We confirmed that 4 small nucleolar RNAs (snoRNAs), ACA48, U35, U55, and U83A, are significantly down-regulated in PBMC from veterans with mTBI and PTSD compared to non-TBI, control subjects with PTSD only...
2014: American Journal of Neurodegenerative Disease
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