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Frontiers in Cellular and Infection Microbiology

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https://www.readbyqxmd.com/read/28326294/the-eukaryote-like-serine-threonine-kinase-stk-regulates-the-growth-and-metabolism-of-zoonotic-streptococcus-suis
#1
Chunyan Zhang, Wen Sun, Meifang Tan, Mengmeng Dong, Wanquan Liu, Ting Gao, Lu Li, Zhuofei Xu, Rui Zhou
Like eukaryotes, bacteria express one or more serine/threonine kinases (STKs) that initiate diverse signaling networks. The STK from Streptococcus suis is encoded by a single-copy stk gene, which is crucial in stress response and virulence. To further understand the regulatory mechanism of STK in S. suis, a stk deletion strain (Δstk) and its complementary strain (CΔstk) were constructed to systematically decode STK characteristics by applying whole transcriptome RNA sequencing (RNA-Seq) and phosphoproteomic analysis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28326293/pily1-promotes-legionella-pneumophila-infection-of-human-lung-tissue-explants-and-contributes-to-bacterial-adhesion-host-cell-invasion-and-twitching-motility
#2
Julia Hoppe, Can M Ünal, Stefanie Thiem, Louisa Grimpe, Torsten Goldmann, Nikolaus Gaßler, Matthias Richter, Olga Shevchuk, Michael Steinert
Legionnaires' disease is an acute fibrinopurulent pneumonia. During infection Legionella pneumophila adheres to the alveolar lining and replicates intracellularly within recruited macrophages. Here we provide a sequence and domain composition analysis of the L. pneumophila PilY1 protein, which has a high homology to PilY1 of Pseudomonas aeruginosa. PilY1 proteins of both pathogens contain a von Willebrand factor A (vWFa) and a C-terminal PilY domain. Using cellular fractionation, we assigned the L. pneumophila PilY1 as an outer membrane protein that is only expressed during the transmissive stationary growth phase...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28321389/host-fih-mediated-asparaginyl-hydroxylation-of-translocated-legionella-pneumophila-effectors
#3
Christopher Price, Michael Merchant, Snake Jones, Ashley Best, Juanita Von Dwingelo, Matthew B Lawrenz, Nawsad Alam, Ora Schueler-Furman, Yousef A Kwaik
FIH-mediated post-translational modification through asparaginyl hydroxylation of eukaryotic proteins impacts regulation of protein-protein interaction. We have identified the FIH recognition motif in 11 Legionella pneumophila translocated effectors, YopM of Yersinia, IpaH4.5 of Shigella and an ankyrin protein of Rickettsia. Mass spectrometry analyses of the AnkB and AnkH effectors of L. pneumophila confirm their asparaginyl hydroxylation. Consistent with localization of the AnkB effector to the Legionella-containing vacuole (LCV) membrane and its modification by FIH, our data show that FIH and its two interacting proteins, Mint3 and MT1-MMP are acquired by the LCV in a Dot/Icm type IV secretion-dependent manner...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28316955/commentary-teratogenic-effects-of-the-zika-virus-and-the-role-of-the-placenta
#4
COMMENT
Shu Yuan, Qin Luo, Zhong-Wei Zhang, Zi-Lin Li
No abstract text is available yet for this article.
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28299286/the-rickettsia-conorii-adr1-interacts-with-the-c-terminus-of-human-vitronectin-in-a-salt-sensitive-manner
#5
Abigail I Fish, Sean P Riley, Birendra Singh, Kristian Riesbeck, Juan J Martinez
Spotted fever group (SFG) Rickettsia species are inoculated into the mammalian bloodstream by hematophagous arthropods. Once in the bloodstream and during dissemination, the survival of these pathogens is dependent upon the ability of these bacteria to evade serum-borne host defenses until a proper cellular host is reached. Rickettsia conorii expresses an outer membrane protein, Adr1, which binds the complement inhibitory protein vitronectin to promote resistance to the anti-bacterial effects of the terminal complement complex...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28299285/a-genetic-screen-reveals-novel-targets-to-render-pseudomonas-aeruginosa-sensitive-to-lysozyme-and-cell-wall-targeting-antibiotics
#6
Kang-Mu Lee, Keehoon Lee, Junhyeok Go, In Ho Park, Jeon-Soo Shin, Jae Young Choi, Hyun Jik Kim, Sang Sun Yoon
Pseudomonas aeruginosa is capable of establishing airway infections. Human airway mucus contains a large amount of lysozyme, which hydrolyzes bacterial cell walls. P. aeruginosa, however, is known to be resistant to lysozyme. Here, we performed a genetic screen using a mutant library of PAO1, a prototype P. aeruginosa strain, and identified two mutants (ΔbamB and ΔfabY) that exhibited decrease in survival after lysozyme treatment. The bamB and fabY genes encode an outer membrane assembly protein and a fatty acid synthesis enzyme, respectively...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28293545/helicobacter-pylori-secreted-protein-hp1286-triggers-apoptosis-in-macrophages-via-tnf-independent-and-erk-mapk-dependent-pathways
#7
Raquel Tavares, Sushil Kumar Pathak
Macrophages constitute a powerful line of defense against H. pylori. The final disease outcome is highly dependent on the bacterial ability to modulate the effector functions of activated macrophages. Here, we report that H. pylori secreted protein HP1286 is a novel regulator of macrophage responses. Differential expression and release of HP1286 homologues were observed among H. pylori strains. Recombinant purified HP1286 (rHP1286) had the ability to bind to primary human monocyte-derived macrophages (MDM) and macrophage cell lines...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28293544/induction-of-atypical-autophagy-by-porcine-hemagglutinating-encephalomyelitis-virus-contributes-to-viral-replication
#8
Ning Ding, Kui Zhao, Yungang Lan, Zi Li, Xiaoling Lv, Jingjing Su, Huijun Lu, Feng Gao, Wenqi He
Autophagy is a basic biological metabolic process involving in intracellular membrane transport pathways that recycle cellular components and eliminate intracellular microorganisms within the lysosome. Autophagy also plays an important part in virus infection and propagation. However, some pathogens, including viruses, have evolved unique trick to escape or exploit autophagy. This study explores the mechanism of autophagy induction by porcine hemagglutinating encephalomyelitis virus (PHEV) in Neuro-2a cells, and examines the role of autophagy in PHEV replication...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28293543/the-tudor-staphylococcal-nuclease-protein-of-entamoeba-histolytica-participates-in-transcription-regulation-and-stress-response
#9
Javier Cázares-Apátiga, Christian Medina-Gómez, Bibiana Chávez-Munguía, Mercedes Calixto-Gálvez, Esther Orozco, Carlos Vázquez-Calzada, Aarón Martínez-Higuera, Mario A Rodríguez
Entamoeba histolytica is the protozoa parasite responsible of human amoebiasis, disease that causes from 40,000 to 100,000 deaths annually worldwide. However, few are known about the expression regulation of molecules involved in its pathogenicity. Transcription of some virulence-related genes is positively controlled by the cis-regulatory element named URE1. Previously we identified the transcription factor that binds to URE1, which displayed a nuclear and cytoplasmic localization. This protein belongs to the Tudor Staphyococcal nuclease (TSN) family, which in other systems participates in virtually all pathways of gene expression, suggesting that this amoebic transcription factor (EhTSN; former EhURE1BP) could also play multiple functions in E...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28293542/whole-genome-sequence-and-phylogenetic-analysis-show-helicobacter-pylori-strains-from-latin-america-have-followed-a-unique-evolution-pathway
#10
Zilia Y Muñoz-Ramírez, Alfonso Mendez-Tenorio, Ikuko Kato, Maria M Bravo, Cosmeri Rizzato, Kaisa Thorell, Roberto Torres, Francisco Aviles-Jimenez, Margarita Camorlinga, Federico Canzian, Javier Torres
Helicobacter pylori (HP) genetics may determine its clinical outcomes. Despite high prevalence of HP infection in Latin America (LA), there have been no phylogenetic studies in the region. We aimed to understand the structure of HP populations in LA mestizo individuals, where gastric cancer incidence remains high. The genome of 107 HP strains from Mexico, Nicaragua and Colombia were analyzed with 59 publicly available worldwide genomes. To study bacterial relationship on whole genome level we propose a virtual hybridization technique using thousands of high-entropy 13 bp DNA probes to generate fingerprints...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28293541/high-content-imaging-reveals-expansion-of-the-endosomal-compartment-during-coxiella-burnetii-parasitophorous-vacuole-maturation
#11
Charles L Larson, Robert A Heinzen
Coxiella burnetii is an obligate intracellular pathogen and the causative agent of human Q fever. Replication of the bacterium within a large parasitophorous vacuole (PV) resembling a host phagolysosome is required for pathogenesis. PV biogenesis is a pathogen driven process that requires engagement of several host cell vesicular trafficking pathways to acquire vacuole components. The goal of this study was to determine if infection by C. burnetii modulates endolysosomal flux to potentially benefit PV formation...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28286742/persistent-exposure-to-porphyromonas-gingivalis-promotes-proliferative-and-invasion-capabilities-and-tumorigenic-properties-of-human-immortalized-oral-epithelial-cells
#12
Fengxue Geng, Junchao Liu, Yan Guo, Chen Li, Hongyang Wang, Hongyan Wang, Haijiao Zhao, Yaping Pan
Recent epidemiological studies revealed a significant association between oral squamous cell carcinoma (OSCC) and Porphyromonas gingivalis, a major pathogen of periodontal disease. As a keystone pathogen of periodontitis, P. gingivalis is known not only to damage local periodontal tissues, but also to evade the host immune system and eventually affect systemic health. However, its role in OSCC has yet to be defined. To explore the underlying effect of chronic P. gingivalis infection on OSCC and to identify relevant biomarkers as promising targets for therapy and prevention, we established a novel model by exposing human immortalized oral epithelial cells (HIOECs) to P...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28286741/sampling-strategies-for-three-dimensional-spatial-community-structures-in-ibd-microbiota-research
#13
REVIEW
Shaocun Zhang, Xiaocang Cao, He Huang
Identifying intestinal microbiota is arguably an important task that is performed to determine the pathogenesis of inflammatory bowel diseases (IBD); thus, it is crucial to collect and analyze intestinally-associated microbiota. Analyzing a single niche to categorize individuals does not enable researchers to comprehensively study the spatial variations of the microbiota. Therefore, characterizing the spatial community structures of the inflammatory bowel disease microbiome is critical for advancing our understanding of the inflammatory landscape of IBD...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28286740/long-term-safety-of-topical-bacteriophage-application-to-the-frontal-sinus-region
#14
Amanda J Drilling, Mian L Ooi, Dijana Miljkovic, Craig James, Peter Speck, Sarah Vreugde, Jason Clark, Peter-John Wormald
Background:Staphylococcus aureus biofilms contribute negatively to a number of chronic conditions, including chronic rhinosinusitis (CRS). With the inherent tolerance of biofilm-bound bacteria to antibiotics and the global problem of bacterial antibiotic resistance, the need to develop novel therapeutics is paramount. Phage therapy has previously shown promise in treating sinonasal S. aureus biofilms. Methods: This study investigates the long term (20 days) safety of topical sinonasal flushes with bacteriophage suspensions...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28280716/aflatoxin-b1-induces-reactive-oxygen-species-mediated-autophagy-and-extracellular-trap-formation-in-macrophages
#15
Yanan An, Xiaochen Shi, Xudong Tang, Yang Wang, Fengge Shen, Qiaoli Zhang, Chao Wang, Mingguo Jiang, Mingyuan Liu, Lu Yu
Aflatoxins are a group of highly toxic mycotoxins with high carcinogenicity that are commonly found in foods. Aflatoxin B1 (AFB1) is the most toxic member of the aflatoxin family. A recent study reported that AFB1 can induce autophagy, but whether AFB1 can induce extracellular traps (ETs) and the relationships among innate immune responses, reactive oxygen species (ROS), and autophagy and the ETs induced by AFB1 remain unknown. Here, we demonstrated that AFB1 induced a complete autophagic process in macrophages (MΦ) (THP-1 cells and RAW264...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28280715/enterotype-may-drive-the-dietary-associated-cardiometabolic-risk-factors
#16
Ana C F de Moraes, Gabriel R Fernandes, Isis T da Silva, Bianca Almeida-Pititto, Everton P Gomes, Alexandre da Costa Pereira, Sandra R G Ferreira
Analyses of typical bacterial clusters in humans named enterotypes may facilitate understanding the host differences in the cardiometabolic profile. It stills unknown whether the three previously described enterotypes were present in populations living below the equator. We examined how the identification of enterotypes could be useful to explain the dietary associations with cardiometabolic risk factors in Brazilian subjects. In this cross-sectional study, a convenience sample of 268 adults (54.2% women) reported their dietary habits and had clinical and biological samples collected...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28280714/anti-biofilm-activity-of-a-long-chain-fatty-aldehyde-from-antarctic-pseudoalteromonas-haloplanktis-tac125-against-staphylococcus-epidermidis-biofilm
#17
Angela Casillo, Rosanna Papa, Annarita Ricciardelli, Filomena Sannino, Marcello Ziaco, Marco Tilotta, Laura Selan, Gennaro Marino, Maria M Corsaro, Maria L Tutino, Marco Artini, Ermenegilda Parrilli
Staphylococcus epidermidis is a harmless human skin colonizer responsible for ~20% of orthopedic device-related infections due to its capability to form biofilm. Nowadays there is an interest in the development of anti-biofilm molecules. Marine bacteria represent a still underexploited source of biodiversity able to synthesize a broad range of bioactive compounds, including anti-biofilm molecules. Previous results have demonstrated that the culture supernatant of Antarctic marine bacterium Pseudoalteromonas haloplanktis TAC125 impairs the formation of S...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28275586/colistin-resistance-in-acinetobacter-baumannii-mdr-zj06-revealed-by-a-multiomics-approach
#18
Xiaoting Hua, Lilin Liu, Youhong Fang, Qiucheng Shi, Xi Li, Qiong Chen, Keren Shi, Yan Jiang, Hua Zhou, Yunsong Yu
Acinetobacter baumannii has emerged as an important opportunistic pathogen due to its ability to acquire resistance to most currently available antibiotics. Colistin is often considered as the last line of therapy for infections caused by multidrug-resistant A. baumannii (MDRAB). However, colistin-resistant A. baumannii strain has recently been reported. To explore how multiple drug-resistant A. baumannii responded to colistin resistance, we compared the genomic, transcriptional and proteomic profile of A. baumannii MDR-ZJ06 to the induced colistin-resistant strain ZJ06-200P5-1...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28275585/mutational-pressure-in-zika-virus-local-adar-editing-areas-associated-with-pauses-in-translation-and-replication
#19
Vladislav V Khrustalev, Tatyana A Khrustaleva, Nitin Sharma, Rajanish Giri
Zika virus (ZIKV) spread led to the recent medical health emergency of international concern. Understanding the variations in virus system is of utmost need. Using available complete sequences of ZIKV we estimated directions of mutational pressure along the length of consensus sequences of three lineages of the virus. Results showed that guanine usage is growing in ZIKV RNA plus strand due to adenine to guanine transitions, while adenine usage is growing due to cytosine to adenine transversions. Especially high levels of guanine have been found in two-fold degenerated sites of certain areas of RNA plus strand with high amount of secondary structure...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28275584/vitamin-c-pretreatment-enhances-the-antibacterial-effect-of-cold-atmospheric-plasma
#20
Saga Helgadóttir, Santosh Pandit, Venkata R S S Mokkapati, Fredrik Westerlund, Peter Apell, Ivan Mijakovic
Bacterial biofilms are three-dimensional structures containing bacterial cells enveloped in a protective polymeric matrix, which renders them highly resistant to antibiotics and the human immune system. Therefore, the capacity to make biofilms is considered as a major virulence factor for pathogenic bacteria. Cold Atmospheric Plasma (CAP) is known to be quite efficient in eradicating planktonic bacteria, but its effectiveness against biofilms has not been thoroughly investigated. The goal of this study was to evaluate the effect of exposure of CAP against mature biofilm for different time intervals and to evaluate the effect of combined treatment with vitamin C...
2017: Frontiers in Cellular and Infection Microbiology
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