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Andrology

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https://www.readbyqxmd.com/read/27907978/comparison-of-the-single-dose-pharmacokinetics-pharmacodynamics-and-safety-of-two-novel-oral-formulations-of-dimethandrolone-undecanoate-dmau-a-potential-oral-male-contraceptive
#1
R Ayoub, S T Page, R S Swerdloff, P Y Liu, J K Amory, A Leung, L Hull, D Blithe, A Christy, J H Chao, W J Bremner, C Wang
Dimethandrolone (DMA, 7α,11β-dimethyl-19-nortestosterone) has both androgenic and progestational activities, ideal properties for a male hormonal contraceptive. In vivo, dimethandrolone undecanoate (DMAU) is hydrolyzed to DMA. We showed previously that single oral doses of DMAU powder in capsule taken with food are well tolerated and effective at suppressing both LH and testosterone (T), but absorption was low. We compared the pharmacokinetics and pharmacodynamics of two new formulations of DMAU, in castor oil and in self-emulsifying drug delivery systems (SEDDS), with the previously tested powder formulation...
December 1, 2016: Andrology
https://www.readbyqxmd.com/read/27871129/a-comment-on-the-discussion-and-application-of-statistical-methods-in-mandrup-et%C3%A2-al-low-dose-effects-of-bisphenol-a-on-mammary-gland-development-in-rats-andrology-4-673-683-2016
#2
LETTER
R P Felton, B E Juliar, G R Olson, K B Delclos
No abstract text is available yet for this article.
November 21, 2016: Andrology
https://www.readbyqxmd.com/read/27860459/adjusting-for-abstinence-time-in-semen-analyses-some-considerations
#3
LETTER
K A Michels, K Kim, E H Yeung, T C Plowden, E N Chaljub, Y-L Lu, S L Mumford
No abstract text is available yet for this article.
November 17, 2016: Andrology
https://www.readbyqxmd.com/read/27860400/identification-of-protein-changes-in-human-spermatozoa-throughout-the-cryopreservation-process
#4
O A Bogle, K Kumar, C Attardo-Parrinello, S E M Lewis, J M Estanyol, J L Ballescà, R Oliva
Cryoinjury is a consequence of cryopreservation and may have a negative impact on sperm quality regarding motility, morphology, and viability. This study was designed to identify potential proteomic changes in human sperm cells throughout the cryopreservation process. Comparisons made within this study included the detection of the sperm proteomic changes induced by incubation of the sperm cells with a protein-free cryoprotectant (with and without CryoSperm), and the proteomic changes induced by freezing, thawing, and subsequent after-thawing incubation at two different temperatures (0 °C vs...
November 17, 2016: Andrology
https://www.readbyqxmd.com/read/27860356/micro-endoscopy-of-the-human-vas-deferens-a-feasibility-study-of-a-novel-device-in-several-ex-vivo-models
#5
M Trottmann, R Sroka, C Braun, B Liedl, H Schaaf, M Graw, A J Becker, C G Stief, W Y Khoder
The aim of this study was to show limitation as well as potential of micro-endoscopy techniques as an innovative diagnostic and therapeutic approach in andrology. Two kinds of custom-made micro-endoscopes (ME) were tested in ex vivo vas deferens specimen and in post-mortem whole body. The semi-rigid ME included a micro-optic (0.9 mm outer diameter [OD], 10.000 pixels, 120° vision angle [VE], 3-20 mm field depth [FD]) and an integrated fibre-optic light source. The flexible ME was composed of a micro-optic (OD = 0...
November 17, 2016: Andrology
https://www.readbyqxmd.com/read/27860455/papaverine-sensitive-phosphodiesterase-activity-is-measured-in-bovine-spermatozoa
#6
A Bergeron, A Hébert, C Guillemette, A Laroche, M-P Poulin, J P Aragon, P Leclerc, R Sullivan, P Blondin, C Vigneault, F J Richard
Cyclic adenosine monophosphate (cAMP) plays a crucial role as a signaling molecule for capacitation, motility, and acrosome reaction in mammalian spermatozoa. It is well-known that cAMP degradation by phosphodiesterase (PDE) enzyme has a major impact on sperm functions. This study was undertaken to characterize cAMP-PDE activity in bovine spermatozoa. Total cAMP-PDE activity in cauda epididymal and ejaculated spermatozoa was 543.2 ± 49.5 and 1252.6 ± 86.5 fmoles/min/10(6) spermatozoa, respectively. Using different family-specific PDE inhibitors, we showed that in cauda epididymal and ejaculated spermatozoa, the major cAMP-PDE activity was papaverine-sensitive (44...
November 16, 2016: Andrology
https://www.readbyqxmd.com/read/27860441/effects-of-human-chorionic-gonadotropin-on-testicular-interstitial-tissues-in-men-with-non-obstructive-azoospermia
#7
S Oka, K Shiraishi, H Matsuyama
Non-obstructive azoospermia is a severe condition because spermatogenesis per se is disrupted. Although microdissection testicular sperm extraction is the standard therapy for non-obstructive azoospermia, sperm retrieval is unsuccessful in approximately 50% of patients. For these patients, we conducted human chorionic gonadotropin-based salvage hormonal therapy, and sperm retrieval was possible in 10-20% of patients. The objectives of this study were to assess the changes in interstitial lesions in patients with non-obstructive azoospermia and to evaluate the effects of human chorionic gonadotropin on these tissues...
November 16, 2016: Andrology
https://www.readbyqxmd.com/read/27860425/centrally-mediated-ejaculatory-response-via-sympathetic-outflow-in-rats-role-of-n-methyl-d-aspartic-acid-receptors-in-paraventricular-nucleus
#8
J-D Xia, J Chen, H-J Sun, L-H Zhou, G-Q Zhu, Y Chen, Y-T Dai
Ejaculation is mediated by a spinal generator, which integrates inputs related to the sexual activity and coordinates sympathetic, parasympathetic, and motor outflow. Previous clinical studies indicate that primary premature ejaculation is related to the hyperactivity of the sympathetic nervous system. In this study, we explored the roles of N-methyl-D-aspartic acid (NMDA) receptors in paraventricular nucleus of the hypothalamus (PVN) on ejaculatory responses and its potential mechanism in the rats. We found that microinjection of 0...
November 16, 2016: Andrology
https://www.readbyqxmd.com/read/27863106/2-arachidonoylglycerol-levels-are-increased-in-leukocytospermia-and-correlate-with-seminal-macrophages
#9
A Barbonetti, T Bisogno, N Battista, F Piscitelli, A Micillo, S Francavilla, M Maccarrone, F Francavilla
Evidence has been produced that macrophages can actively generate endocannabinoids (eCBs) in response to inflammatory stimuli. As eCBs are involved in the control of several physiological processes, including reproduction, here, we explored whether seminal levels of the eCBs, N-arachidonoylethanolamine (AEA), and 2-arachidonoylglycerol (2-AG), were higher in the presence of leukocytospermia, and were correlated with semen concentration of macrophages. The content of AEA and 2-AG was measured by high-performance liquid chromatography/mass spectrometry in seminal plasma of ejaculates from 18 leukocytospermic patients (>1 × 10(6) leukocytes/mL) and 21 normozoospermic controls...
November 11, 2016: Andrology
https://www.readbyqxmd.com/read/27813378/genetic-variation-in-leptin-and-leptin-receptor-genes-as-a-risk-factor-for-idiopathic-male-infertility
#10
A Hodžić, M Ristanović, B Zorn, C Tulić, A Maver, I Novaković, D Plaseska-Karanfilska, B Peterlin
The aim of this study was to examine whether there is an association among genetic variability in leptin (LEP) and leptin receptor (LEPR) genes and male infertility. We performed a case-control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (SNPs) in LEP gene and four single nucleotide polymorphisms (SNPs) in LEPR gene were chosen and genotyped...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27813377/metabolic-syndrome-and-the-seminal-cytokine-network-in-morbidly-obese-males
#11
A Pilatz, C Hudemann, J Wolf, I Halefeld, A Paradowska-Dogan, H-C Schuppe, H Hossain, Q Jiang, D Schultheiss, H Renz, W Weidner, F Wagenlehner, T Linn
Given the increasing prevalence of metabolic syndrome (MetS) in males of reproductive age, the objective of this prospective case-controlled study was to investigate the impact of subacute systemic inflammation associated with MetS on seminal cytokines and standard sperm parameters in comparison with healthy men. Between 2011 and 2014, we recruited 27 patients with MetS out of 41 obese patients screened from an internal outpatient clinic. Twenty-seven age-matched healthy controls were enrolled from 54 men requesting vasectomy in a urological outpatient clinic...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27813361/high-serum-dihydrotestosterone-examined-by-ultrasensitive-lc-ms-ms-as-a-predictor-of-benign-prostatic-hyperplasia-or-gleason-score-6-cancer-in-men-with-prostate-specific-antigen-levels-of-3-10%C3%A2-ng-ml
#12
Y Miyoshi, H Uemura, K Suzuki, Y Shibata, S Honma, M Harada, Y Kubota
There has been no consensus on the role of serum androgen concentrations in prostate cancer detection in men with prostate-specific antigen levels of 3-10 ng/mL. In this study, testosterone and dihydrotestosterone concentrations in blood were examined by a newly developed method using ultrasensitive liquid chromatography with two serially linked mass spectrometers (LC-MS/MS). We investigated the correlation between serum androgen levels and Gleason scores at biopsy. We analyzed data of 157 men with a total prostate-specific antigen range of 3-10 ng/mL who underwent initial systematic prostate needle biopsy for suspected prostate cancer between April 2000 and July 2003...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27813338/dutasteride-mediated-morphological-changes-in-the-genitourinary-tract-associated-with-altered-expression-patterns-of-the-androgen-and-estrogen-receptors-in-male-rats
#13
N Enatsu, K Chiba, K Sumii, T Fukuda, K Okada, K Matsushita, M Fujisawa
We evaluated the effects of dutasteride on the genitourinary tract using fifteen 8-week-old male Sprague-Dawley rats. Animals were divided into three groups comprising five animals each and treated as follows. Group A was a control group, members of Group B received oral administration of dutasteride 0.1 mg/kg/day from the age of 8 to 16 weeks, and members of Group C were castrated at the age of 8 weeks. All rats were killed at the age of 16 weeks for the sample collection of blood, bladder, prostate, seminal vesicles, and penis...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27792869/testosterone-vs-aromatase-inhibitor-in-older-men-with-low-testosterone-effects-on-cardiometabolic-parameters
#14
J P Dias, M D Shardell, O D Carlson, D Melvin, G Caturegli, L Ferrucci, C W Chia, J M Egan, S Basaria
Testosterone (T) replacement is being increasingly offered to older men with age-related decline in testosterone levels. The effects of long-term testosterone replacement and aromatase inhibition (AI) on glucose homeostasis and cardiometabolic markers were determine in older non-diabetic men with low testosterone levels. Men ≥65 years, mean age 71 ± 3 years with serum total T < 350 ng/dL were randomized in a double-blind, placebo-controlled, parallel-group, proof-of-concept trial evaluating the effects of 5 g transdermal testosterone gel (TT) (n = 10), 1 mg anastrozole (n = 10) or placebo (n = 9) daily for 12 months...
October 28, 2016: Andrology
https://www.readbyqxmd.com/read/27792863/association-of-vitamin-d-status-with-semen-quality-and-reproductive-hormones-in-iranian-subfertile-men
#15
Sh Abbasihormozi, A Kouhkan, A R Alizadeh, A Shahverdi, M H Nasr-Esfahani, M A Sadighi Gilani, R Salman Yazdi, A Matinibehzad, Z Zolfaghari
Although vitamin D deficiency is one of the most common health problems throughout the world, including Iran, conflicting information exists on the potential association between serum vitamin D levels and semen quality. This study intended to evaluate the association between serum vitamin D [25(OH) D3] with semen quality and hormones in Iranian subfertile men. We also compared mean vitamin D and hormone levels in normospermic men with oligoasthenoteratozoospermia (OAT) men. This cross-sectional study was conducted on 278 men who were referred to Royan Infertility Clinic (Tehran, Iran) from March to September 2014...
October 28, 2016: Andrology
https://www.readbyqxmd.com/read/27792861/pre-diabetes-and-serum-sex-steroid-hormones-among-us-men
#16
R Arthur, S Rohrmann, H Møller, E Selvin, A S Dobs, N Kanarek, W Nelson, E A Platz, M Van Hemelrijck
Several studies demonstrate a link between diabetes and sex steroid hormones, but the link with pre-diabetes remains elusive. In this study, we hypothesize that pre-diabetes, which is characterised by having impaired fasting glucose and/or impaired glucose tolerance and/or impaired HbA1C, may influence circulating sex steroid hormone concentrations in men. Thus, we investigated whether serum sex steroid hormone concentrations differ between men with and without pre-diabetes. We analyzed data for 1139 men who were aged 20+ years when they participated in the Third National Health and Nutrition Examination Survey...
October 28, 2016: Andrology
https://www.readbyqxmd.com/read/27792860/a-data-driven-search-for-semen-related-phenotypes-in-conception-delay
#17
C J Patel, R Sundaram, G M Buck Louis
Sperm count, morphology, and motility have been reported to be predictive of pregnancy, although with equivocal basis prompting some authors to question the prognostic value of semen analysis. To assess the utility of including semen quality data in predicting conception delay or requiring >6 cycles to become pregnant (referred to as conception delay), we utilized novel data-driven analytic techniques in a pre-conception cohort of couples prospectively followed up for time-to-pregnancy. The study cohort comprised 402 (80%) male partners who provided semen samples and had time-to-pregnancy information...
October 28, 2016: Andrology
https://www.readbyqxmd.com/read/27769104/overexpression-of-cyp19a1-aromatase-in-leydig-cells-is-associated-with-steroidogenic-dysfunction-in-subjects-with-sertoli-cell-only-syndrome
#18
M C Lardone, F Argandoña, M Flórez, A Parada-Bustamante, M Ebensperger, C Palma, A Piottante, A Castro
Several observational studies have showed a combination of lower testosterone (T) to LH ratio and higher estradiol (E2 ) to T ratio in secretory infertile men compared to men with normal spermatogenesis, suggesting a steroidogenic dysfunction of Leydig cells (Lc) that may involve increased aromatase activity. Low T/LH ratio is associated with Lc hyperplasia, which together with LH hyperstimulation may represent compensation for impaired T production. Aromatase expression and oestrogen production are mainly detected in Lc of the testis, although Sertoli and germ cells also contribute to testicular aromatase activity...
October 21, 2016: Andrology
https://www.readbyqxmd.com/read/27769103/kinetic-activity-membrane-mitochondrial-potential-lipid-peroxidation-intracellular-ph-and-calcium-of-frozen-thawed-bovine-spermatozoa-treated-with-metabolic-enhancers
#19
R Boni, A Gallo, S Cecchini
Owing to the progressive decline of sperm motility during storage there is a need to find substances capable of enhancing sperm energy metabolism and motility and/or preserving it from oxidative damage. The aim of this study was to evaluate in frozen/thawed bovine spermatozoa the effect of several compounds, such as myo-inositol, pentoxifylline, penicillamine + hypotaurine + epinephrine mixture (PHE), caffeine and coenzyme Q10+ zinc + d-aspartate mixture (CZA), on either kinetic or metabolic parameters. Sperm kinetics was evaluated by Sperm Class Analyser whereas specific fluorochromes were used to evaluated mitochondrial membrane potential (MMP), intracellular pH, intracellular calcium concentration and lipid peroxidation...
October 21, 2016: Andrology
https://www.readbyqxmd.com/read/27748062/comparison-of-combined-antioxidants-and-thymoquinone-in-the-prevention-of-testis-ischemia-reperfusion-injury
#20
B Erol, U Sari, A S Amasyali, S Ozkanli, S Sogut, V Hanci, O Efiloglu, Y O Danacioglu, P Engin, F Yencilek, G Atis, A Yildirim, O A Alkoc, T Caskurlu
We aimed to compare the preventive effects of combined antioxidants (CA1, 2) with a single antioxidant drug (thymoquinone; TQ) on experimental testis Ischemia/Reperfusion (I/R) injury. Thirty-five adult male Wistar rats were divided into five groups of seven rats each: control, testis I/R, testis I/R + CA1, testis I/R + CA2, and testis I/R + TQ. After 1 h of testicular ischemia, reperfusion was achieved by detorsion for 4 h. Antioxidants were intraperitoneally administered for 30 min prior to reperfusion...
October 16, 2016: Andrology
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