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Global Heart

Tomoyuki Kawada
No abstract text is available yet for this article.
October 20, 2016: Global Heart
Alvaro Avezum, Gustavo B F Oliveira, Fernando Lanas, Patricio Lopez-Jaramillo, Rafael Diaz, J Jaime Miranda, Pamela Seron, Paul A Camacho-Lopez, Andres Orlandini, Antonio Bernabe-Ortiz, Antônio Cordeiro Mattos, Shofiqul Islam, Sumathy Rangarajan, Koon Teo, Salim Yusuf
BACKGROUND: Despite the availability of evidence-based therapies, there is no information on the use of medications for the secondary prevention of cardiovascular disease in urban and rural community settings in South America. OBJECTIVES: This study sought to assess the use, and its predictors, of effective secondary prevention therapies in individuals with a history of coronary heart disease (CHD) or stroke. METHODS: In the PURE (Prospective Urban Rural Epidemiological) study, we enrolled 24,713 individuals from South America ages 35 to 70 years from 97 rural and urban communities in Argentina, Brazil, Chile, and Colombia...
October 20, 2016: Global Heart
Alice Grainger-Gasser, Pablo Perel, Léna Lagier-Hässig, David Wood
No abstract text is available yet for this article.
October 6, 2016: Global Heart
M Mostafa Zaman, Sohel Reza Choudhury, Jasimuddin Ahmed, Rezaul Karim Khandaker, Mian Abdur Rouf, Abdul Malik
No abstract text is available yet for this article.
August 4, 2016: Global Heart
George A Mensah
The MESA (Multi-Ethnic Study of Atherosclerosis) has been highly successful in investigating the prevalence, characteristics, and progression of subclinical cardiovascular disease (CVD) in a multiethnic American cohort of adult men and women free of CVD at baseline. MESA has also championed the use of novel biomarkers and emerging imaging techniques for the assessment of subclinical CVD and has created an extensive set of data that continues to fuel dozens of ongoing analyses. Insights from MESA include the first demonstration of ethnic differences in coronary artery calcification and its association with subclinical disease progression and incident CVD...
September 2016: Global Heart
Ana V Diez Roux, Mahasin S Mujahid, Jana A Hirsch, Kari Moore, Latetia V Moore
Cardiovascular disease (CVD) continues to be the leading cause of death and a major source of health disparities in the Unites States and globally. Efforts to reduce CVD risk and eliminate cardiovascular health disparities have increasingly emphasized the importance of the social determinants of health. Neighborhood environments have emerged as a possible target for prevention and policy efforts. Hence there is a need to better understand the role of neighborhood environments in shaping cardiovascular risk...
September 2016: Global Heart
Joel D Kaufman, Elizabeth W Spalt, Cynthia L Curl, Anjum Hajat, Miranda R Jones, Sun-Young Kim, Sverre Vedal, Adam A Szpiro, Amanda Gassett, Lianne Sheppard, Martha L Daviglus, Sara D Adar
The MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution) leveraged the platform of the MESA cohort into a prospective longitudinal study of relationships between air pollution and cardiovascular health. MESA Air researchers developed fine-scale, state-of-the-art air pollution exposure models for the MESA Air communities, creating individual exposure estimates for each participant. These models combine cohort-specific exposure monitoring, existing monitoring systems, and an extensive database of geographic and meteorological information...
September 2016: Global Heart
Alain G Bertoni, Holly Kramer, Karol Watson, Wendy S Post
Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure...
September 2016: Global Heart
Nancy Swords Jenny, Nels C Olson, Matthew A Allison, Dena E Rifkin, Lori B Daniels, Ian H de Boer, Christina L Wassel, Russell P Tracy
This review provides background on the laboratory design for MESA (Multi-Ethnic Study of Atherosclerosis) as well as the approach used in MESA to select biomarkers for measurement. The research related to the multitude of circulating and urinary biomarkers of inflammation and other novel and emerging biological pathways in MESA is summarized by domain, or pathway, represented by the biomarker. The contributions of MESA biomarkers to our knowledge of these key pathways in the development and progression of atherosclerosis, cardiovascular disease, diabetes, kidney disease, and pulmonary disease are highlighted, as are the contributions of MESA to recommendations for clinical use of several of these biomarkers...
September 2016: Global Heart
Michael H Criqui, Victor Aboyans, Matthew A Allison, Julie O Denenberg, Nketi Forbang, Mary M McDermott, Christina L Wassel, Nathan D Wong
We reviewed published MESA (Multi-Ethnic Study of Atherosclerosis) study articles concerning peripheral arterial disease, subclavian stenosis (SS), abdominal aortic calcium (AAC), and thoracic artery calcium (TAC). Important findings include, compared to non-Hispanic whites, lower ankle-brachial index (ABI) and more SS in African Americans, and higher ABI and less SS in Hispanic and Chinese Americans. Abnormal ABI and brachial pressure differences were associated with other subclinical cardiovascular disease (CVD) measures...
September 2016: Global Heart
Joseph F Polak, Daniel H O'Leary
Carotid artery intima-media thickness (IMT) is a noninvasive measurement of the artery wall thickness, inclusive of atherosclerotic plaque, obtained using ultrasound imaging. In the MESA (Multi-Ethnic Study of Atherosclerosis) study, IMT measurements are used as a surrogate for subclinical cardiovascular disease and as a variable predictive of cardiovascular events. IMT measurements of the common carotid artery are available in more than 99% of the MESA population and are predictive of cardiovascular events...
September 2016: Global Heart
Kazuhiro Osawa, Rine Nakanishi, Matthew Budoff
Coronary artery calcification (CAC) is an established marker of subclinical atherosclerosis and an independent predictor of future coronary heart disease in the asymptomatic primary prevention population, particularly in the intermediate risk cohort. CAC also helps in reclassifying those patients and their risk of cardiovascular events into higher or lower risk categories. MESA (Multi-Ethnic Study of Atherosclerosis) is a National Heart, Lung, and Blood Institute-sponsored population-based medical research study involving 6,814 men and women from 6 U...
September 2016: Global Heart
Michael J Blaha, Joseph Yeboah, Mahmoud Al Rifai, Kiang Liu, Richard Kronmal, Philip Greenland
When the MESA (Multi-Ethnic Study of Atherosclerosis) began, the Framingham risk score was the preferred tool for 10-year global coronary heart disease risk assessment; however, the Framingham risk score had limitations including derivation in a homogenous population lacking racial and ethnic diversity and exclusive reliance on traditional risk factors without consideration of most subclinical disease measures. MESA was designed to study the prognostic value of subclinical atherosclerosis and other risk markers in a multiethnic population...
September 2016: Global Heart
Jean L Olson, Diane E Bild, Richard A Kronmal, Gregory L Burke
The MESA (Multi-Ethnic Study of Atherosclerosis) was initiated to address unresolved questions about subclinical cardiovascular disease and its progression to clinically overt cardiovascular disease in a diverse population-based sample, incorporating emerging imaging technologies for better evaluation of subclinical disease and creating a population laboratory for future research. MESA's recruited (from 2000 to 2002) cohort comprised >6,000 adults from 4 racial/ethnic groups, ages 45 to 84 years, who were free of cardiovascular disease at baseline...
September 2016: Global Heart
Gregory Burke, Joao Lima, Nathan D Wong, Jagat Narula
No abstract text is available yet for this article.
September 2016: Global Heart
Michael M Engelgau, Emmanuel Peprah, Uchechukwu K A Sampson, Helena Mishoe, Ivor J Benjamin, Pamela S Douglas, Judith S Hochman, Paul M Ridker, Neal Brandes, William Checkley, Sameh El-Saharty, Majid Ezzati, Anselm Hennis, Lixin Jiang, Harlan M Krumholz, Gabrielle Lamourelle, Julie Makani, K M Venkat Narayan, Kwaku Ohene-Frempong, Sharon E Straus, David Stuckler, David A Chambers, Deshirée Belis, Glen C Bennett, Josephine E Boyington, Tony L Creazzo, Janet M de Jesus, Chitra Krishnamurti, Mia R Lowden, Antonello Punturieri, Susan T Shero, Neal S Young, Shimian Zou, George A Mensah
Almost three-quarters (74%) of all the noncommunicable disease burden is found within low- and middle-income countries. In September 2014, the National Heart, Lung, and Blood Institute held a Global Health Think Tank meeting to obtain expert advice and recommendations for addressing compelling scientific questions for late stage (T4) research-research that studies implementation strategies for proven effective interventions-to inform and guide the National Heart, Lung, and Blood Institute's global health research and training efforts...
July 21, 2016: Global Heart
Olalekan A Uthman, Louise Hartley, Karen Rees, Fiona Taylor, Shah Ebrahim, Aileen Clarke
This study sought to determine the effectiveness of multiple risk factor interventions aimed at modifying major cardiovascular risk factors for the primary prevention of cardiovascular disease in low- and middle-income countries (LMIC). We searched electronic databases for randomized controlled trials of health promotion interventions to achieve behavior change. The pooled effect indicated a reduction in systolic blood pressure (-6.72 mm Hg; 95% confidence interval [CI]: -9.82 to -3.61; I(2) = 91%), diastolic blood pressure (-4...
July 21, 2016: Global Heart
Diego Enriquez, Ricardo Mastandueno, Daniel Flichtentrei, Edgardo Szyld
BACKGROUND: The question of whether or not to allow family to be present during resuscitation is relevant to everyday professional health care assistance, but it remains largely unexplored in the medical literature. OBJECTIVES: We conducted an online survey with the aim of increasing our knowledge and understanding of this issue. METHODS: This is a cross-sectional, multicenter, descriptive, national, and international study using a web-based, voluntary survey...
June 3, 2016: Global Heart
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Global Heart
George A Mensah
No abstract text is available yet for this article.
June 2016: Global Heart
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