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Global Heart

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https://www.readbyqxmd.com/read/28528248/interethnic-differences-in-serum-lipids-implications-for-cardiometabolic-disease-risk-in-african-ancestry-populations
#1
REVIEW
Amy R Bentley, Charles N Rotimi
African Americans generally have a healthier lipid profile (lower triglycerides and higher high-density lipoprotein cholesterol concentration) compared with those of other ethnicities. Paradoxically, African Americans do not experience a decreased risk of the cardiometabolic diseases that serum lipids are expected to predict. This review explores this mismatch between biomarker and disease among African ancestry individuals by investigating the presence of interethnic differences in the biological relationships underlying the serum lipids-disease association...
May 17, 2017: Global Heart
https://www.readbyqxmd.com/read/28433492/is-tavr-ready-for-the-global-aging-population
#2
REVIEW
Travis Bergmann, Partho P Sengupta, Jagat Narula
The emergence of the global pandemic of chronic diseases necessitates critical assessment of interventions that can be targeted at both the individual and population levels. Among cardiovascular diseases, the increasing prevalence of valvular heart diseases such as aortic stenosis parallels the rising burden of atherosclerotic cardiovascular diseases. As an alternative to surgical aortic valve replacement, technological innovation has allowed development of minimally invasive transcatheter aortic valve replacement (TAVR)...
April 19, 2017: Global Heart
https://www.readbyqxmd.com/read/28433491/youth-engagement-for-ncd-prevention-policies-rising-ncd-in-india-and-youth-as-change-enablers
#3
EDITORIAL
Ishu Kataria, Jennifer L Cruz
No abstract text is available yet for this article.
April 19, 2017: Global Heart
https://www.readbyqxmd.com/read/28433490/evaluating-health-of-emerging-economies-through-the-eyes-of-heart-valve-disease-in%C3%A2-the%C3%A2-transcatheter-era
#4
REVIEW
Sameer Arora, Cassandra J Ramm, Amol A Bahekar, John P Vavalle
China and India are the 2 fastest growing major world economies. However, they suffer from great differences in health policies, demographics, and rates of population growth. Whereas China has seen a steep decline in rheumatic heart disease (RHD) and a rise in life expectancy, India continues to suffer from a significant burden of RHD due to insufficient distribution of economic prosperity to health care, denser population, and ineffective application of World Health Organization RHD prevention guidelines. As China faces the burden of the world's largest geriatric population, focus has shifted to calcific aortic stenosis for which it prepares by expansions in the field of transcatheter aortic valve replacement...
April 19, 2017: Global Heart
https://www.readbyqxmd.com/read/28411147/20-year-trend-of-cardiovascular-disease-risk-factors-urban-and-rural-national-capital-region-of-delhi-india
#5
Dorairaj Prabhakaran, Ambuj Roy, Pradeep A Praveen, Lakshmy Ramakrishnan, Ruby Gupta, Ritvik Amarchand, Dimple Kondal, Kalpana Singh, Meenakshi Sharma, Deepak Kumar Shukla, Nikhil Tandon, Kolli Srinath Reddy, Anand Krishnan
BACKGROUND: The World Health Organization and the Government of India have set targets to reduce burden of noncommunicable diseases. Information on population level trend of risk factors would provide insights regarding the possibility of achieving them. OBJECTIVE: This study aimed to determine the population trends of cardiovascular disease risk factors in the National Capital Region of Delhi over 2 decades. METHODS: Two representative cross-sectional surveys were conducted among men and women ages 35 to 64 years, residing in the urban and rural areas (survey 1 [1991 to 1994] and survey 2 [2010 to 2012]) using similar methodology...
April 11, 2017: Global Heart
https://www.readbyqxmd.com/read/28408189/genetic-effects-on-the-correlation-structure-of%C3%A2-cvd-risk-factors-exome-wide-data-from-a-ghanaian-population
#6
REVIEW
Nuri Kodaman, Rafal S Sobota, Folkert W Asselbergs, Matthew T Oetjens, Jason H Moore, Nancy J Brown, Melinda C Aldrich, Scott M Williams
Plasma concentration of plasminogen activator inhibitor-1 (PAI-1) is highly correlated with several cardiovascular disease (CVD) risk factors. It also plays a direct role in CVD, including myocardial infarction and stroke, by impeding the dissolution of thrombi in the blood. Insofar as PAI-1 links CVD's risk factors to its endpoints, genetic variants modulating the relationship between PAI-1 and risk factors may be of particular clinical and biological interest. The high heritability of PAI-1, which has not been explained by genetic association studies, may also, in large part, be due to this relationship with CVD risk factors...
April 10, 2017: Global Heart
https://www.readbyqxmd.com/read/28377104/neurological-complications-in-subjects-with-sickle-cell-disease-or-trait-an-observational-study-from-mali
#7
Guida Landouré, Lassana Cissé, Boubacar A Touré, Abdoulaye Yalcouyé, Toumany Coulibaly, Mamadou Karambé, Adama S Sissoko, Thomas Coulibaly, Ambroise Wonkam, Cheick O Guinto
No abstract text is available yet for this article.
April 1, 2017: Global Heart
https://www.readbyqxmd.com/read/28351700/sex-ethnicity-and-cvd-among-women-of-african-descent-an-approach-for-the-new-era-of-genomic-research
#8
Whitney L Barfield, Cheryl Anne Boyce
No abstract text is available yet for this article.
March 25, 2017: Global Heart
https://www.readbyqxmd.com/read/28336388/the-importance-of-conducting-stroke-genomics-research-in-african-ancestry-populations
#9
REVIEW
Huichun Xu, Braxton D Mitchell, Emmanuel Peprah, Steven J Kittner, John W Cole
No abstract text is available yet for this article.
March 20, 2017: Global Heart
https://www.readbyqxmd.com/read/28336387/the-word-heart-federation-roadmap-for-nonvalvular-atrial-fibrillation
#10
Adrianna Murphy, Amitava Banerjee, Günter Breithardt, A John Camm, Patrick Commerford, Ben Freedman, J Antonio Gonzalez-Hermosillo, Jonathan L Halperin, Chu-Pak Lau, Pablo Perel, Denis Xavier, David Wood, Xavier Jouven, Carlos A Morillo
BACKGROUND: The World Heart Federation has undertaken an initiative to develop a series of Roadmaps to promote development of national policies and health systems approaches, and to identify potential roadblocks on the road to effective prevention, detection, and management of cardiovascular disease in low-and middle-income countries (LMICs) and develop strategies for overcoming these. This Roadmap focuses on atrial fibrillation (AF). AF is the most common, clinically significant arrhythmia and, among other clinical outcomes, is associated with increased risk of stroke...
March 20, 2017: Global Heart
https://www.readbyqxmd.com/read/28336386/the-whf-roadmap-for-reducing-cv-morbidity-and-mortality-through-prevention-and-control-of-rheumatic-heart-disease
#11
Benjamin Palafox, Ana Olga Mocumbi, R Krishna Kumar, Sulafa K M Ali, Elizabeth Kennedy, Abraham Haileamlak, David Watkins, Kadia Petricca, Rosemary Wyber, Patrick Timeon, Jeremiah Mwangi
Rheumatic heart disease (RHD) is a preventable non-communicable condition that disproportionately affects the world's poorest and most vulnerable. The World Heart Federation Roadmap for improved RHD control is a resource designed to help a variety of stakeholders raise the profile of RHD nationally and globally, and provide a framework to guide and support the strengthening of national, regional and global RHD control efforts. The Roadmap identifies the barriers that limit access to and uptake of proven interventions for the prevention and control of RHD...
March 20, 2017: Global Heart
https://www.readbyqxmd.com/read/28302546/rheumatic-heart-disease-epidemiology-and-health-systems-barriers-and-facilitators-a-systematic-review-of-studies-from-uganda-and-tanzania
#12
Annesinah H Moloi, Sumaya Mall, Mark E Engel, Renae Stafford, Zhang Wan Zhu, Liesl J Zuhlke, David A Watkins
BACKGROUND: Rheumatic heart disease (RHD) is an important and preventable cause of cardiovascular disease. OBJECTIVES: As part of a recent RHD initiative in Uganda and Tanzania, we systematically reviewed group A streptococcal disease (GAS), acute rheumatic fever (ARF), and RHD in these countries. METHODS: Using a systematic review and meta-analysis/meta-synthesis, we searched PubMed, Embase, and grey literature for quantitative and qualitative studies conducted in Uganda and Tanzania that included individuals affected by GAS, ARF, and RHD...
March 14, 2017: Global Heart
https://www.readbyqxmd.com/read/28302557/prevalence-and-prognostic-features-of-ecg-abnormalities-in-acute-stroke-findings-from-the-siren-study-among-africans
#13
Abiodun M Adeoye, Okechukwu S Ogah, Bruce Ovbiagele, Rufus Akinyemi, Vincent Shidali, Francis Agyekum, Akinyemi Aje, Oladimeji Adebayo, Joshua O Akinyemi, Philip Kolo, Lambert Tetteh Appiah, Henry Iheonye, Uwanuruochi Kelechukwu, Amusa Ganiyu, Taiwo O Olunuga, Onoja Akpa, Ojo Olakanmi Olagoke, Fred Stephen Sarfo, Kolawole Wahab, Samuel Olowookere, Adekunle Fakunle, Albert Akpalu, Philip B Adebayo, Kwadwo Nkromah, Joseph Yaria, Philip Ibinaiye, Godwin Ogbole, Aridegbe Olumayowa, Sulaiman Lakoh, Benedict Calys-Tagoe, Paul Olowoyo, Chukwuonye Innocent, Hemant K Tiwari, Donna Arnett, Osaigbovo Godwin, Bisi Ayotunde, Josephine Akpalu, Okeke Obiora, Odo Joseph, Adeleye Omisore, Carolyn Jenkins, Daniel Lackland, Lukman Owolabi, Suleiman Isah, Abdu H Dambatta, Morenikeji Komolafe, Andrew Bock-Oruma, Ezinne Sylvia Melikam, Lucius Chidiebere Imoh, Taofiki Sunmonu, Mulugeta Gebregziabher, Oluyemisi Olabisi, Kevin Armstrong, Ugochukwu U Onyeonoro, Emmanuel Sanya, Atinuke M Agunloye, Luqman Ogunjimi, Oyedunni Arulogun, Temitope H Farombi, Olugbo Obiabo, Reginald Obiako, Mayowa Owolabi
BACKGROUND: Africa has a growing burden of stroke with associated high morbidity and a 3-year fatality rate of 84%. Cardiac disease contributes to stroke occurrence and outcomes, but the precise relationship of abnormalities as noted on a cheap and widely available test, the electrocardiogram (ECG), and acute stroke outcomes have not been previously characterized in Africans. OBJECTIVES: The study assessed the prevalence and prognoses of various ECG abnormalities among African acute stroke patients encountered in a multisite, cross-national epidemiologic study...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302556/genomics-research-for-a-new-age-examining-how-our-shared-evolutionary-history-shapes-future-disease-outcomes
#14
REVIEW
Fasil Tekola-Ayele, Emmanuel Peprah
Cardiometabolic diseases are major contributors to mortality and morbidity, and their burden displays global and regional disparities. Gene-environment interactions contribute to the pathogenesis of cardiometabolic diseases. Population differences in genetic structure, ancient environmental pressures that shape the human genome, and early life environmental adversities (e.g., in utero conditions) all contribute to observed disparities in global cardiometabolic diseases. The genetic and sociocultural diversity of global populations presents opportunities for discovering genomic loci that influence cardiometabolic diseases as illustrated by a few genetic, epigenetic, and population-genetic discoveries leading to notable understanding of disease mechanisms...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302555/development-of-bioinformatics-infrastructure-for-genomics-research-in-h3africa
#15
Nicola J Mulder, Ezekiel Adebiyi, Marion Adebiyi, Seun Adeyemi, Azza Ahmed, Rehab Ahmed, Bola Akanle, Mohamed Alibi, Don L Armstrong, Shaun Aron, Efejiro Ashano, Shakuntala Baichoo, Alia Benkahla, David K Brown, Emile R Chimusa, Faisal M Fadlelmola, Dare Falola, Segun Fatumo, Kais Ghedira, Amel Ghouila, Scott Hazelhurst, Itunuoluwa Isewon, Segun Jung, Samar Kamal Kassim, Jonathan K Kayondo, Mamana Mbiyavanga, Ayton Meintjes, Somia Mohammed, Abayomi Mosaku, Ahmed Moussa, Mustafa Muhammd, Zahra Mungloo-Dilmohamud, Oyekanmi Nashiru, Trust Odia, Adaobi Okafor, Olaleye Oladipo, Victor Osamor, Jellili Oyelade, Khalid Sadki, Samson Pandam Salifu, Jumoke Soyemi, Sumir Panji, Fouzia Radouani, Oussama Souiai, Özlem Tastan Bishop
BACKGROUND: Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, was established to build capacity specifically to enable H3Africa (Human Heredity and Health in Africa) researchers to analyze their data in Africa. Since the inception of the H3Africa initiative, H3ABioNet's role has evolved in response to changing needs from the consortium and the African bioinformatics community...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302554/structure-based-analysis-of-single-nucleotide-variants-in-the-renin-angiotensinogen-complex
#16
David K Brown, Olivier Sheik Amamuddy, Özlem Tastan Bishop
BACKGROUND: The renin-angiotensin system (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. Three classes of drugs have been developed to inhibit RAS. In this study, we provide a structure-based analysis of the effect of single nucleotide variants (SNVs) on the interaction between renin and angiotensinogen with the aim of revealing important residues and potentially damaging variants for further inhibitor design purposes...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302553/stark-regional-and-sex-differences-in-the-prevalence-and-awareness-of-hypertension-an-h3africa-awi-gen-study-across-6-sites-in-sub-saharan-africa
#17
F Xavier Gómez-Olivé, Stuart A Ali, Felix Made, Catherine Kyobutungi, Engelbert Nonterah, Lisa Micklesfield, Marianne Alberts, Romuald Boua, Scott Hazelhurst, Cornelius Debpuur, Felistas Mashinya, Sekgothe Dikotope, Hermann Sorgho, Ian Cook, Stella Muthuri, Cassandra Soo, Freedom Mukomana, Godfred Agongo, Christopher Wandabwa, Sulaimon Afolabi, Abraham Oduro, Halidou Tinto, Ryan G Wagner, Tilahun Haregu, Alisha Wade, Kathleen Kahn, Shane A Norris, Nigel J Crowther, Stephen Tollman, Osman Sankoh, Michèle Ramsay
BACKGROUND: There is a high prevalence of hypertension and related cardiovascular diseases in sub-Saharan Africa, yet few large studies exploring hypertension in Africa are available. The actual burden of disease is poorly understood and awareness and treatment to control it is often suboptimal. OBJECTIVES: The study sought to report the prevalence of measured hypertension and to assess awareness and control of blood pressure among older adults in rural and urban settings in 6 sites located in West, East, and Southern Africa...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302552/exploring-overlaps-between-the-genomic-and-environmental-determinants-of-lvh-and-stroke-a-multicenter-study-in-west-africa
#18
Abiodun M Adeoye, Bruce Ovbiagele, Philip Kolo, Lambert Appiah, Akinyemi Aje, Oladimeji Adebayo, Fred Sarfo, Joshua Akinyemi, Gregory Adekunle, Francis Agyekum, Vincent Shidali, Okechukwu Ogah, Dan Lackland, Mulugeta Gebregziabher, Donna Arnett, Hemant K Tiwari, Rufus Akinyemi, Ojo Olakanmi Olagoke, Ayodipupo Sikiru Oguntade, Taiwo Olunuga, Kelechi Uwanruochi, Carolyn Jenkins, Patrick Adadey, Henry Iheonye, Lukman Owolabi, Reginald Obiako, Samuel Akinjopo, Kevin Armstrong, Albert Akpalu, Adekunle Fakunle, Raelle Saulson, Mayowa Aridegbe, Paul Olowoyo, Godwin Osaigbovo, Josephine Akpalu, Bimbo Fawale, Philip Adebayo, Oyedunni Arulogun, Philip Ibinaiye, Atinuke Agunloye, Naser Ishaq, Kolawole Wahab, Onoja Akpa, Omisore Adeleye, Andrew Bock-Oruma, Godwin Ogbole, Sylvia Melikam, Joseph Yaria, Luqman Ogunjimi, Abdul Salaam, Taofiki Sunmonu, Akintomiwa Makanjuola, Temitope Farombi, Ruth Laryea, Ezinne Uvere, Salaam Kehinde, Innocent Chukwuonye, Paschal Azuh, Morenikeji Komolafe, Adeseye Akintunde, Olugbo Obiabo, Olusegun Areo, Issa Kehinde, Adeniyi G Amusa, Mayowa Owolabi
BACKGROUND: Whether left ventricular hypertrophy (LVH) is determined by similar genomic and environmental risk factors with stroke, or is simply an intermediate stroke marker, is unknown. OBJECTIVES: We present a research plan and preliminary findings to explore the overlap in the genomic and environmental determinants of LVH and stroke among Africans participating in the SIREN (Stroke Investigative Research and Education Network) study. METHODS: SIREN is a transnational, multicenter study involving acute stroke patients and age-, ethnicity-, and sex-matched control subjects recruited from 9 sites in Ghana and Nigeria...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302551/role-of-structural-bioinformatics-in-drug-discovery-by-computational-snp-analysis-a-proposed-protocol-for-analyzing-variation-at-the-protein-level
#19
REVIEW
David K Brown, Özlem Tastan Bishop
With the completion of the human genome project at the beginning of the 21st century, the biological sciences entered an unprecedented age of data generation, and made its first steps toward an era of personalized medicine. This abundance of sequence data has led to the proliferation of numerous sequence-based techniques for associating variation with disease, such as genome-wide association studies and candidate gene association studies. However, these statistical methods do not provide an understanding of the functional effects of variation...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302550/the-22q11-2-deletion-syndrome-in-congenital-heart-defects-prevalence-of-microdeletion-syndrome-in-cameroon
#20
Ambroise Wonkam, Ricardo Toko, David Chelo, Cedrik Tekendo-Ngongang, Samuel Kingue, Sophie Dahoun
BACKGROUND: The 22q11.2 deletion syndrome is amongst the most common microdeletion syndrome in humans. Its prevalence remains unknown in sub-Saharan Africa, and its clinical features are under-reported for people of African descent. OBJECTIVE: We have investigated the prevalence of the 22q11.2 deletion syndrome in patients with congenital heart defects in Cameroon. METHODS: A total of 70 of 100 cases of congenital cardiac malformation with echocardiographic evidence were examined prospectively and tested for the 22q11...
March 13, 2017: Global Heart
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