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Taiwan Journal of Ophthalmology

Chu-Yen Huang, Eugene Yu-Chuan Kang, Kuan-Jen Chen, Nan-Kai Wang
A 51-year-old man had experienced declining visual acuity for 4 months. His best-corrected visual acuity was 20/40 in both eyes. Ophthalmoscopic examination showed a yellowish placoid lesion over the macular area, and spectral-domain optical coherence tomography (SD-OCT) revealed subretinal fluid accumulation in the left eye, which resembled that seen with central serous chorioretinopathy (CSCR). Three days later, fluorescein angiography (FA) revealed fluorescein leakage, and indocyanine green angiography (ICGA) showed hypofluorescence over the lesion...
July 2018: Taiwan Journal of Ophthalmology
Chia-Jui Chang, Shih-Jen Chen, De-Kuang Hwang, Catherine Jui-Ling Liu
Immune checkpoint blockade therapy is relatively a new treatment for cancer which has shown promising results. However, immune-related side effects including uveitis have occasionally been reported during this therapy. Herein, we report the case of a 65-year-old male who suffered bilateral anterior uveitis after immune checkpoint blockade therapy with pembrolizumab and ipilimumab for malignant melanoma. His symptoms and signs improved after topical treatment with corticosteroids. Clinicians should be aware that uveitis can be an immune-related adverse event of immunotherapy...
July 2018: Taiwan Journal of Ophthalmology
Yung Jen Lai, Wei-Chun Chan
We report a young male patient with Behçet's disease who suffered from sight-threatening recurrences under treatment with azathioprine, cyclosporine, and prednisolone. His uveitis responded well to antitumor necrosis factor (TNF)-alpha (adalimumab) for 5 months subsequently. Severe uveitis recurred soon after discontinuation of anti-TNF alpha therapy and could not be controlled well with reinstitution of the anti-TNF alpha therapy. Interferon- α 2a (IFN- α 2a) was then given along with low-dose oral prednisone (10 mg/day), and the uveitis responded well to this therapy...
July 2018: Taiwan Journal of Ophthalmology
Wei-Ning Ku, Chun-Ju Lin, Yi-Yu Tsai
We report the rescue effects of adalimumab (HUMIRA® ) therapy in a case of refractory pediatric panuveitis complicated with steroid-induced glaucoma. A 13-year-old girl had suffered from blurred vision since January 2013. Bilateral idiopathic panuveitis with macular edema (ME) was diagnosed. She had previously been treated with systemic steroids, methotrexate, cyclosporine, and mycophenolate. All treatments had failed to suppress the ocular inflammation and ME persisted. Intravitreal dexamethasone implant injections were given to both eyes and ME subsided; however, complications with steroid-induced glaucoma and cataract occurred...
July 2018: Taiwan Journal of Ophthalmology
Ning-Yi Hsia, You-Ling Li, Chun-Ju Lin, Henry Bair, Chun-Ting Lai, Jane-Ming Lin, Wen-Lu Chen, Peng-Tai Tien, Chung-Yuan Kuo, Yi-Yu Tsai
PURPOSE: The aim of this study is to evaluate the clinical use of ultra-widefield angiography (UWFA) in uveitis. MATERIALS AND METHODS: We showed the UWFA and traditional 55° fluorescein angiography (FA) of four cases with Eales' disease, idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome, Behçet's disease, and idiopathic panuveitis in a tertiary medical center. Comparison of UWFA with traditional 55°FA in the diagnosis and management of uveitis and review of the literature is also presented...
July 2018: Taiwan Journal of Ophthalmology
Yuan-Yao Fan, Chi-Chin Sun, Hung-Chi Chen, David Hui-Kang Ma
PURPOSE: The aim of this study is to evaluate the effectiveness and predictability of photorefractive keratectomy (PRK) for correcting residual refractive error following cataract surgery with premium intraocular lens (IOL) implantation. METHODS: We conducted a retrospective review of the medical records of patients who received PRK for correcting residual hyperopia, myopia, and/or astigmatism due to unsatisfied uncorrected distance visual acuity (UDVA) after cataract extraction with implantation of aspheric, diffractive multifocal, or toric IOL from September 2011 to December 2017...
July 2018: Taiwan Journal of Ophthalmology
Manish Nagpal, Navneet Mehrotra, Rakesh Juneja, Hardik Jain
Context: Role of Ozurdex in macular edema due to various posterior segment pathologies. AIM: The aim of this study is to report outcome of Ozurdex implant in macular edema (ME) secondary to various posterior segment pathologies. SETTINGS AND DESIGN: This was a single-center, retrospective, interventional study. SUBJECTS AND METHODS: Patients of ME were treated with one or more Ozurdex implants (0.7 mg). Data collection included demographic details, best-corrected visual acuity (BCVA), central foveal thickness (CFT), duration of efficacy, and record of adverse events (if any) within 24 weeks...
July 2018: Taiwan Journal of Ophthalmology
Marie Joan Therese D Balgos, Veronica Vargas, Jorge L Alió
Presbyopia results from loss or insufficiency of the eye's accommodative ability, and clinically manifests as the inability to focus near objects on the retina. It is one of the most common causes of visual impairment worldwide especially in adults of productive or working age. Various means of compensating for the loss of accommodative ability have been devised from optical tools such as spectacles and contact lenses, to topical medications and to surgical procedures. A comprehensive search on journal articles about topical and surgical correction of presbyopia was undertaken...
July 2018: Taiwan Journal of Ophthalmology
De-Kuang Hwang, Yih-Shiou Hwang, Ming-Ling Tsai, Chun-Ju Lin, Wei-Chun Chan, Yo-Chen Chang, Der-Yuan Chen, Tsu-Yi Hsieh, Shwu-Jiuan Sheu, Chang-Ping Lin
Noninfectious uveitis is a sight-threatening disease with an autoimmune or autoinflammatory basis. Systemic treatment is required if intraocular inflammation threatens a patient's vision or cannot be controlled locally and when it is associated with systemic rheumatic diseases. Corticosteroids and immunomodulatory chemotherapy are the conventional initial treatments. However, the various side effects of these therapies increase the burden on patients, not only physically but also mentally. Moreover, uncontrolled inflammation and poor visual outcomes have sometimes been recorded despite the combination of these medications or their high dosage...
July 2018: Taiwan Journal of Ophthalmology
Chang-Ping Lin
No abstract text is available yet for this article.
July 2018: Taiwan Journal of Ophthalmology
Antonio Sesar, Ivan Cavar, Anita Pusic Sesar, Irena Sesar
Posterior reversible encephalopathy syndrome (PRES) is a clinical condition that can cause different ophthalmological and neurological symptoms. Preeclampsia toxemia or eclampsia is one of the leading causes of PRES. Herein, we present a study of a 35-year old woman who gave birth to healthy twins at 35 weeks of gestation by cesarean section because of threatened preterm delivery. On the 1st postoperative day, the woman developed a severe headache, arterial hypertension, tachycardia, generalized tonic-clonic seizures, and loss of consciousness that persisted for about 2 min...
April 2018: Taiwan Journal of Ophthalmology
Chia-Yi Lee, Hung-Chi Chen, Hung-Yu Lin, Ling-Yuh Kao
We report a case presenting with bilateral oculomotor nerve palsy (ONP) resulting from a midbrain hemorrhage. The patient visited the ophthalmological clinic due to the sudden onset of horizontal diplopia for a week. Bilateral ONP spared the left eye levator and bilateral pupils were found while the remaining results of examinations were unremarkable. Cerebral magnetic resonance imaging revealed a midbrain hemorrhage. Mono-ocular occlusion was arranged, and the patient was referred to a neurologist for further management...
April 2018: Taiwan Journal of Ophthalmology
Shin-Yu Chang, Shawn H Tsai, Lee-Jen Chen, Wei-Chun Chan, Yeou-Ping Tsao
We presented a rare case of a sole choroidal metastatic tumor from esophageal squamous cell carcinoma (ESCC) without other organ metastasis in Taiwan. A 43-year-old male with ESCC was referred for a 1-month history of decreased vision in his left eye. A 5.7 mm thick, yellow choroidal tumor occupied posterior pole, featured with pinpoint hyperfluorescence on angiography and subretinal fluid on optical coherence tomography. Positron emission tomography showed a singular hypermetabolic focus in the left eye. The tumor regressed with complete response and the vision preserved after radiation with total 57...
April 2018: Taiwan Journal of Ophthalmology
Nitin Nema, Sonam Verma, Ravindra Kumar
PURPOSE: Thromboembolic phenomenon is one of the causes of retinal vein occlusion (RVO) which is in fact a multifactorial disease. Therefore, we aimed to study methylenetetrahydrofolate reductase gene polymorphism (MTHFR C677T) and factor V Leiden as genetic risk factors of RVO. MATERIALS AND METHODS: A total of 50 (19 males and 31 females) cases of RVO were compared with 50 age- and sex-matched (21 males and 29 females) controls. Complete ocular examination was done for all samples...
April 2018: Taiwan Journal of Ophthalmology
Lubna Khan, Babita Sharma, Harshal Gupta, Rimpi Rana
INTRODUCTION: A comparison of precision of intraocular implant power calculation by computing keratometry values by two different methods, namely, the automated and manual keratometry (MK), was done. For checking this accuracy, the parameter taken into consideration was the absolute refractive error which was ascertained postoperatively. SUBJECTS AND METHODS: This study was conducted in the Department of Ophthalmology, Sri Aurobindo Institute of Medical Sciences and PG Institute, Indore...
April 2018: Taiwan Journal of Ophthalmology
K Monsudi Fasasi, Abdulkabir Ayansiji Ayanniyi
CONTEXT: Cataract is the most common cause of blindness worldwide. Meeting World Health Organization Vision 2020 cataract surgical rate target for Africa remains a dream. Inadequate resource to deliver quality cataract services is burdensome. AIMS: The aim of the study was to evaluate the resource for cataract services in Kebbi, Nigeria. SETTINGS AND DESIGN: A descriptive and analytic cross-sectional study using a quantitative questionnaire...
April 2018: Taiwan Journal of Ophthalmology
Yan-Ting Chen, San-Ni Chen, Chin-San Liu
PURPOSE: The purpose of this research is to evaluate the relationship between of optic atrophy 1 (OPA1) polymorphism and normal tension glaucoma (NTG) by surveying patients from central Taiwan. This study finding could help us to understand the impact of OPA1 polymorphism on glaucoma. METHODS: We try to identify the effect of OPA1 polymorphism by comparing the clinical presentation in three catalogs of gene polymorphism in patients with NTG. Our research team includes patients with NTG from central Taiwan and assesses the OPA1 intervening sequence 8 (IVS8) + 4 C->T and IVS8 + 32 T->C polymorphism...
April 2018: Taiwan Journal of Ophthalmology
Syed Shoeb Ahmad
Glaucoma suspects are controversial clinical dilemmas. These individuals harbor certain risk factors or demonstrate some clinical features suggestive of an increased probability to develop glaucomatous optic atrophy in the future. These characteristics range from high intraocular pressure; optic disc, visual field, or retinal nerve fiber layer abnormalities; or abnormal angles to a positive family history of glaucoma and other risk factors. Individuals having these characteristics should be assessed diligently before a diagnosis of glaucoma is made...
April 2018: Taiwan Journal of Ophthalmology
Chao-Wen Lin, Ta-Ching Chen, Jieh-Ren Jou, Lin-Chung Woung
Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction. Autoantibodies to the acetylcholine receptor or, less frequently, to muscle-specific kinase, attack against the postsynaptic junctional proteins, resulting in fluctuating and variable weakness of muscles. Extraocular, levator palpebrae superioris, and orbicularis oculi muscles are particularly susceptible. The majority of patients with MG present with purely ocular symptoms including ptosis and diplopia initially. About half of these patients progress to generalized disease within 2 years...
April 2018: Taiwan Journal of Ophthalmology
Hongfang Yang, Xiaobo Yu, Xinghuai Sun
Neovascular glaucoma (NVG), which is refractory to both medical management and surgical intervention, is a disastrous ocular disease for it always ends up with intolerable pain and extinguishing patients' residual visual function. Since insufficient acknowledge of the pathophysiological and molecular mechanisms of NVG, it has been laying a challenging dilemma of managing NVG in clinical practice for a long time. Along with the progression on some new agents and surgical options targeting certain possible roles in the NVG process, there seems having been some new sights but still much unknown and to be revealed...
April 2018: Taiwan Journal of Ophthalmology
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