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RSC Advances

Michael Chin, Cecilia Cisneros, Stephanie M Araiza, Kevin M Vargas, Kristi M Ishihara, Fangyuan Tian
Adsorption and photodegradation of rhodamine B by ZIF-8 nanocrystals were studied using spectroscopic techniques coupled with density functional theory (DFT) cluster calculations. A fast adsorption rate was observed in the dark, but upon exposure to visible light or UV irradiation the adsorption rate noticeably increased. Although several studies previously reported this phenomenon involving bulk ZIF-8 powder, this is the first mechanistic study to our knowledge that demonstrates adsorption and degradation of rhodamine B by nanosized ZIF-8 under various light conditions...
July 29, 2018: RSC Advances
Peng Zhu, Carl Atkinson, Suraj Dixit, Qi Cheng, Danh Tran, Kunal Patel, Yu-Lin Jiang, Scott Esckilsen, Kayla Miller, Grace Bazzle, Patterson Allen, Alfred Moore, Ann-Marie Broome, Satish N Nadig
Hypothermic preservation is the standard of care for storing organs prior to transplantation. Endothelial and epithelial injury associated with hypothermic storage causes downstream graft injury and, as such, the choice of an ideal donor organ preservation solution remains controversial. Cold storage solutions, by design, minimize cellular necrosis and optimize cellular osmotic potential, but do little to assuage immunological cell activation or immune cell priming post transplantation. Thus, here we explore the efficacy of our previously described novel Targeted Rapamycin Micelles (TRaM) as an additive to standard-of-care University of Wisconsin preservation solution as a means to alter the immunological microenvironment post transplantation using in vivo models of tracheal and aortic allograft transplantation...
July 23, 2018: RSC Advances
Joydeb Mandal, R S Varunprasaath, Wenqing Yan, Mohammad Divandari, Nicholas D Spencer, Matthias Dübner
An investigation of the polymerisation of 2-hydroxyethyl methacrylate (HEMA) by means of surface-initiated atom transfer radical polymerisation (SI-ATRP) has been carried out in situ using a quartz crystal microbalance, with multiple reinitiations under continuous flow of the reaction mixture. The SI-ATRP kinetics of HEMA were studied continuously by means of changes in the frequency, varying conditions including temperature and solvent composition, as well as monomer and catalyst concentrations, showing the influence of key reaction parameters on SI-ATRP kinetics...
June 3, 2018: RSC Advances
Kokkarachedu Varaprasad, Dariela Nunez, Murali Mohan Yallapu, Tippabattini Jayaramudu, Elizabeth Elgueta, Patricio Oyarzun
Herein, two kinds of nano-hydroxyapatite were synthesized from Clam and Magellan shell by wet chemical precipitation method. Mainly, carboxymethyl cellulose/acrylamide/nano-hydroxyapatite composite hydrogels were developed via a free-radical polymerization process and investigated as a sorbent for Acid Blue 113 (AB) from aqueous AB solution. The swelled and kinetic behaviours of hydrogels were investigated using a gravimetric method. The swelling properties of the CMC-AM-hydrogels were influenced by the calcium electrolytes (Ca2+ ) content in nano-hydroxyapatites...
May 16, 2018: RSC Advances
Edyta Niezabitowska, Jessica Smith, Mark R Prestly, Riaz Akhtar, Felix W von Aulock, Yan Lavallée, Hanene Ali-Boucetta, Tom O McDonald
The geometries and surface properties of nanocarriers greatly influence the interaction between nanomaterials and living cells. In this work we combine multiwalled carbon nanotubes (CNTs) with poly-ε-caprolactone (PCL) to produce non-spherical nanocomposites with high aspect ratios by using a facile emulsion solvent evaporation method. Particles were characterised by dynamic light scattering (DLS), scanning electron microscopy (SEM), atomic force microscopy (AFM) and asymmetric flow field flow fractionation (AF4)...
May 7, 2018: RSC Advances
Caroline Kearney, Lukasz T Olenginski, Trexler D Hirn, Gwendolyn D Fowler, Daniyal Tariq, Scott H Brewer, Christine M Phillips-Piro
The vibrational reporter unnatural amino acid (UAA) 4-cyano-l-phenylalanine (pCNF) was genetically incorporated individually at three sites (5, 36, and 78) in the heme protein Caldanaerobacter subterraneus H-NOX to probe local hydration environments. The UAA pCNF was incorporated site-specifically using an engineered, orthogonal tRNA synthetase in E. coli . The ability of all of the pCNF-containing H-NOX proteins to form the ferrous CO, NO, or O2 ligated and unligated states was confirmed with UV-Vis spectroscopy...
April 9, 2018: RSC Advances
Liandong Jing, Yanbo Tang, Masuo Goto, Kuo-Hsiung Lee, Zhiyan Xiao
Cyclin-dependent kinases (CDKs) are pivotal kinases in cell cycle transition and gene transcription. A series of N 2 , N 4 -diphenylpyrimidine-2,4-diamines were previously identified as potent CDK2/CDK9 inhibitors. To explore the SAR of this structural prototype, twenty-four novel N 2 , N 4 -disubstituted pyrimidine-2,4-diamines were designed and synthesized. Among them, twenty-one compounds exhibited potent inhibitory activities against both CDK2/cyclin A and CDK9/cyclin T1 systems, and the most potent CDK2 and CDK9 inhibitors, 3g and 3c , showed IC50 values of 83 nM and 65 nM respectively...
April 2, 2018: RSC Advances
Zewdu M Gebeyehu, Aloïs Arrighi, Marius V Costache, Clivia M Sotomayor-Torres, Maria J Esplandiu, Sergio O Valenzuela
Exposing graphene to a hydrogen post-etching process yields dendritic graphene shapes. Here, we demonstrate that similar dendritic structures can be achieved at long growth times without adding hydrogen externally. These shapes are not a result of a surface diffusion controlled growth but of the competing backward reaction (etching), which dominates the growth dynamics at long times due to an in situ rise in the hydrogen partial pressure. We have performed a systematic study on the growth of graphene as a function of time to identify the onset and gradual evolution of graphene shapes caused by etching and then demonstrated that the etching can be stopped by reducing the flow of hydrogen from the feed...
February 22, 2018: RSC Advances
Roland Thuenauer, Simon Nicklaus, Marco Frensch, Kevin Troendle, Josef Madl, Winfried Römer
A key factor determining the fate of individual cells within an epithelium is the unique microenvironment that surrounds each cell. It regulates location-dependent differentiation into specific cellular sub-types, but, on the other hand, a disturbed microenvironment can promote malignant transformation of epithelial cells leading to cancer formation. Here, we present a tool based on a microfluidic biochip that enables novel research approaches by providing a means to control the basolateral microenvironment of a confined number of neighbouring cells within an epithelial monolayer...
February 19, 2018: RSC Advances
Alexandra Iordachescu, Philippa Hulley, Liam M Grover
Nanovesicles, exosomes and other membrane bound particles excreted by cells are currently gaining research attention since they have been shown to play a significant role in many biologically related processes. Vesicles are now thought to mediate cellular communication, transmission of some diseases and pathologically mediated calcification. Matrix vesicles have long been proposed to be central to the controlled mineralisation of bone. They remain relatively poorly studied, however, since they are challenging to extract from biological media...
February 13, 2018: RSC Advances
Muhammad Waqas Khalid, Rajib Ahmed, Ali K Yetisen, Haider Butt
Optical sensors for detecting temperature and strain play a crucial role in the analysis of environmental conditions and real-time remote sensing. However, the development of a single optical device that can sense temperature and strain simultaneously remains a challenge. Here, a flexible corner cube retroreflector (CCR) array based on passive dual optical sensing (temperature and strain) is demonstrated. A mechanical embossing process was utilised to replicate a three-dimensional (3D) CCR array in a soft flexible polymer film...
February 13, 2018: RSC Advances
Arantxa Fernandes, Robert F Moran, Scott Sneddon, Daniel M Dawson, David McKay, Giulia P M Bignami, Frédéric Blanc, Karl R Whittle, Sharon E Ashbrook
The potential of 17 O NMR spectroscopy for the investigation of A2 B2 O7 ceramic oxides important in the encapsulation of radioactive waste is demonstrated, with post-synthetic enrichment by exchange with 17 O2 gas. For Y2 Sn2 O7 , Y2 Ti2 O7 and La2 Sn2 O7 pyrochlores, enrichment of the two distinct O species is clearly non quantitative at lower temperatures (∼700 °C and below) and at shorter times, despite these being used in prior work, with preferential enrichment of OA2 B2 favoured over that of OA4 ...
February 13, 2018: RSC Advances
N Ganot, E Y Tshuva
Advanced anticancer phenolato titanium(iv) complexes were combined with known chemotherapeutic anticancer drugs applied in the clinic and were analyzed in vitro on cell lines most sensitive to the Ti(iv) complex and relevant to the clinical application of the known drugs. Combination of the Ti(iv) complex with cisplatin on ovarian cells showed mostly an additive behavior, also on a line resistant to cisplatin. Combination of the Ti(iv) complex with fluorouracil on colon cells gave near additive behavior, and that with oxaliplatin gave a synergistic behavior at a wide range of Ti : Pt ratios, but only when the drugs were administered together...
February 5, 2018: RSC Advances
Khang Hoang, Myungkeun Oh, Yongki Choi
Transition-metal tungstates MWO4 (M = Co, Ni, Cu, Zn) have applications in many areas, including supercapacitors. A good understanding of the electronic structure is essential to understanding their functional properties. Here, we report a first-principles study of the materials using hybrid density-functional calculations. The electronic structure is analyzed with a focus on the nature of the electronic states near the band edges. We find that hole polarons can form at the Co lattice site in CoWO4 and the O site in NiWO4 , CuWO4 , and ZnWO4 , resulting in the formation of Co3+ in the former and O- in the latter...
January 23, 2018: RSC Advances
Xiuli Dong, Mohamad Al Awak, Ping Wang, Ya-Ping Sun, Liju Yang
Multi-walled carbon nanotube (MWCNT) filters incorporated with carbon quantum dots (CDots) or single-walled carbon nanotubes (SWCNTs) were produced for bacteria removal from aqueous solutions and also for inactivating the captured bacteria. TMTP Millipore membranes were used as the base of these filters. The results showed that filters with higher MWCNT loading had higher bacterial removal efficiencies. Filters with a MWCNT loading of 4.5 mg were highly effective at removing bacteria from aqueous solution, resulting in a log reduction of 6...
2018: RSC Advances
Zhe Gao, Seyyed Pouya Hadipour Moghaddam, Hamidreza Ghandehari, Ilya Zharov
Silica nanoparticles (SNPs) are attractive for applications for the delivery of drugs and as imaging agents due to their ease of synthesis and scale up, robust structure, and controllable size and composition. Degradability is one important factor that limits biomedical applications of SNPs. With this in mind, we designed, prepared and characterized novel hydrolysable organosilica nanoparticles (ICPTES-Sorbitol SNPs). These particles were prepared by co-condensation of tetraethoxysilane with a bridged sorbitol-based silsesquioxane precursor containing carbamate linkages...
2018: RSC Advances
Sudeshna Manna, Seergazhi G Srivatsan
Biophysical and biochemical investigations provide compelling evidence connecting the four-stranded G-quadruplex (GQ) structure with its role in regulating multiple cellular processes. Hence, modulating the function of GQs by using small molecule binders is being actively pursued as a strategy to develop new chemotherapeutic agents. However, sequence diversity and structural polymorphism of GQs have posed immense challenges in terms of understanding what conformation a G-rich sequence adopts inside the cell and how to specifically target a GQ motif amidst several other GQ-forming sequences...
2018: RSC Advances
Shou-Min Bai, Qiong Wang, Xiao-Li Yu, Ting Chen, Jin Yang, Jun-Tian Shi, Robert Yl Tsai, Hai Huang
Neural stem cells (NSCs) exhibit preferential homing toward some types of brain lesion, but their migratory property during radiation brain injury (RBI) remains unexplored. Here, we use the superparamagnetic iron oxide (SPIO)-labeled magnetic resonance imaging (MRI) technology to determine the migration of transplanted NSCs in two partial RBI models in real time , created by administering 30-55 Gy of radiation to the right or posterior half of the adult rat brain. SPIO-labeled NSCs were stereotactically grafted into the uninjured side one week after RBI...
2018: RSC Advances
Jacopo Marino, Reto Walser, Martin Poms, Oliver Zerbe
Cotranslational protein folding is a vectorial process, and for membrane proteins, N-terminal helical segments are the first that become available for membrane insertion. While structures of many G-protein coupled receptors (GPCRs) in various states have been determined, the details of their folding pathways are largely unknown. The seven transmembrane (TM) helices of GPCRs often contain polar residues within the hydrophobic core, and some of the helices in isolation are predicted to be only marginally stable in a membrane environment...
2018: RSC Advances
Akop Yepremyan, Arshad Mehmood, Samantha Brewer, Madalyn M Barnett, Benjamin G Janesko, Giridhar Akkaraju, Eric E Simanek, Kayla N Green
Interests in inorganic applications of triazines is growing. In this report, metal complexes of copper(II), nickel(II), and zinc(II) and a novel class of chelates comprising a triazine ring substituted with a hydrazine group and pyralozone are evaluated using spectrophotometric methods, single crystal X-ray diffractometry, and electrochemistry. Complexes with copper(II) include a single chelate and two chloride atoms to satisfy a trigonal bipryamidal coordination sphere. The nickel(II) and zinc(II) complexes are comprised of two chelating groups that adopt an octahedral geometry around the metal ion...
2018: RSC Advances
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