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RSC Advances

Akop Yepremyan, Arshad Mehmood, Samantha Brewer, Madalyn M Barnett, Benjamin G Janesko, Giridhar Akkaraju, Eric E Simanek, Kayla N Green
Interests in inorganic applications of triazines is growing. In this report, metal complexes of copper(II), nickel(II), and zinc(II) and a novel class of chelates comprising a triazine ring substituted with a hydrazine group and pyralozone are evaluated using spectrophotometric methods, single crystal X-ray diffractometry, and electrochemistry. Complexes with copper(II) include a single chelate and two chloride atoms to satisfy a trigonal bipryamidal coordination sphere. The nickel(II) and zinc(II) complexes are comprised of two chelating groups that adopt an octahedral geometry around the metal ion...
2018: RSC Advances
Magdalena Bajgrowicz-Cieslak, Yousef Alqurashi, Mohamed Ismail Elshereif, Ali K Yetisen, Muhammad Umair Hassan, Haider Butt
Continuous glucose monitoring aims to achieve accurate control of blood glucose concentration to prevent hypo/hyperglycaemia in diabetic patients. Hydrogel-based systems have emerged as a reusable sensing platform to quantify biomarkers in high-risk patients at clinical and point-of-care settings. The capability to integrate hydrogel-based systems with optical transducers will provide quantitative and colorimetric measurements via spectrophotometric analyses of biomarkers. Here, we created an imprinting method to rapidly produce 2...
November 25, 2017: RSC Advances
Anna Regiel-Futyra, Małgorzata Kus-Liśkiewicz, Victor Sebastian, Silvia Irusta, Manuel Arruebo, Agnieszka Kyzioł, Grażyna Stochel
Severe bacterial and fungal infections have become a major clinical and public health concern. Nowadays, additional efforts are needed to develop effective antimicrobial materials that are not harmful to human cells. This work describes the synthesis and characterization of chitosan-ascorbic acid-silver nanocomposites as films exhibiting high antimicrobial activity and non-cytotoxicity towards human cells. The reductive and stabilizing activity of both the biocompatible polymer chitosan and ascorbic acid were used in the synthesis of silver nanoparticles (AgNPs)...
November 14, 2017: RSC Advances
Cigdem Altintas, Seda Keskin
Metal organic framework (MOF) membranes have been widely investigated for gas separation applications. Several MOFs have been recently examined for selective separation of C2H6. Considering the large number of available MOFs, it is not possible to fabricate and test the C2H6 separation performance of every single MOF membrane using purely experimental methods. In this study, we used molecular simulations to assess the membrane-based C2H6/C2H4 and C2H6/CH4 separation performances of 175 different MOF structures...
November 11, 2017: RSC Advances
Maria Iris Tsionou, Caroline E Knapp, Calum A Foley, Catherine R Munteanu, Andrew Cakebread, Cinzia Imberti, Thomas R Eykyn, Jennifer D Young, Brett M Paterson, Philip J Blower, Michelle T Ma
Gallium-68 (68Ga) is a positron-emitting isotope used for clinical PET imaging of peptide receptor expression. 68Ga radiopharmaceuticals used in molecular PET imaging consist of disease-targeting biomolecules tethered to chelators that complex 68Ga3+. Ideally, the chelator will rapidly, quantitatively and stably coordinate 68Ga3+ at room temperature, near neutral pH and low chelator concentration, allowing for simple routine radiopharmaceutical formulation. Identification of chelators that fulfil these requirements will facilitate development of kit-based 68Ga radiopharmaceuticals...
October 24, 2017: RSC Advances
Jin Zhao, Dongsheng Wen
For enhanced oil recovery (EOR) applications, the oil/water flow characteristics during the flooding process was numerically investigated with the volume-of-fluid method at the pore scale. A two-dimensional pore throat-body connecting structure was established, and four scenarios were simulated in this paper. For oil-saturated pores, the wettability effect on the flooding process was studied; for oil-unsaturated pores, three effects were modelled to investigate the oil/water phase flow behaviors, namely the wettability effect, the interfacial tension (IFT) effect, and the combined wettability/IFT effect...
August 27, 2017: RSC Advances
Meltem Taskin, Alice Cognigni, Ronald Zirbs, Erik Reimhult, Katharina Bica
We report the design and synthesis of surface-active ionic liquids for application in palladium-catalyzed cross coupling reactions. A series of dodecylimidazolium-based ionic liquids were applied as additives in the Heck reaction of ethyl acrylate and iodobenzene, and high yields of >90% could be obtained in water without the addition of further ligands. Our results indicate that the ionic liquid concentration in water is the key factor affecting the formation of the catalytically active species and hence the yield...
August 22, 2017: RSC Advances
Tung-Yi Lin, Trey T Pfeiffer, Peter B Lillehoj
Thermoplastics are becoming a popular material for fabricating microfluidic devices and there is an increasing need for robust surface modification strategies. UV/ozone (UVO) treatment is a simple and effective method for making plastic surfaces more hydrophilic. Prior reports on the stability of UVO-treated plastics are limited to four weeks, which is not sufficient for applications requiring long-term storage. Here, we present new findings on the long-term stability of UVO-treated plastics for up to 16 weeks and show that the storage condition has a significant impact on the surface stability...
July 29, 2017: RSC Advances
Ruth J McQuitty, Sarah Unterkofler, Tijmen G Euser, Philip St J Russell, Peter J Sadler
We explore the efficacy of a hyphenated photonic crystal fibre microflow reactor - high-resolution mass spectrometer system as a method for screening the activity of potential new photoactivatable drugs. The use of light to activate drugs is an area of current development as it offers the possibility of reduced side effects due to improved spatial and temporal targeting and novel mechanisms of anticancer activity. The di-nuclear ruthenium complex [{(η6-indan)RuCl}2(μ-2,3-dpp)](PF6)2, previously studied by Magennis et al...
July 29, 2017: RSC Advances
M H Fletcher, C E Burns-Lynch, K W Knouse, L T Abraham, C W DeBrosse, W M Wuest
Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages.
June 7, 2017: RSC Advances
Mitchell A Kuss, Robert Harms, Shaohua Wu, Ying Wang, Jason B Untrauer, Mark A Carlson, Bin Duan
Reconstruction of complex, craniofacial bone defects often requires autogenous vascularized bone grafts, and still remains a challenge today. In order to address this issue, we isolated the stromal vascular fraction (SVF) from adipose tissues and maintained the phenotypes and the growth of endothelial lineage cells within SVF derived cells (SVFC) by incorporating an endothelial cell medium. We 3D bioprinted SVFC within our hydrogel bioinks and conditioned the constructs in either normoxia or hypoxia. We found that short-term hypoxic conditioning promoted vascularization-related gene expression, whereas long-term hypoxia impaired cell viability and vascularization...
June 5, 2017: RSC Advances
Steven D Quinn, Steven W Magennis
A rapid, sensitive and selective optical readout of the presence of gadolinium(iii) ions would have a wide range of applications for clinical and environmental monitoring. We demonstrate that water-soluble CdTe quantum dots (QDs) are induced to aggregate by Gd3+ ions in aqueous solution. By using a combination of photoluminescence spectroscopy, dynamic light scattering and fluorescence correlation spectroscopy (FCS) to monitor quantum dot aggregation kinetics, we correlate the efficiency of the self-quenching process with the degree of aggregation across a broad range of conditions, including different sizes of QDs...
May 11, 2017: RSC Advances
Nisha Bhattarai, Jeevan B Gc, Bernard S Gerstman, Robert V Stahelin, Prem P Chapagain
Filovirus infections cause hemorrhagic fever in humans and non-human primates that often results in high fatality rates. The Marburg virus is a lipid-enveloped virus from the Filoviridae family and is closely related to the Ebola virus. The viral matrix layer underneath the lipid envelope is formed by the matrix protein VP40 (VP40), which is also involved in other functions during the viral life-cycle. As in the Ebola virus VP40 (eVP40), the recently determined X-ray crystal structure of the Marburg virus VP40 (mVP40) features loops containing cationic residues that form a lipid binding basic patch...
April 26, 2017: RSC Advances
Jürgen Bernard, Eva-Maria Köck, Roland G Huber, Klaus R Liedl, Ludwig Call, Robert Schlögl, Hinrich Grothe, Thomas Loerting
The monoesters of carbonic acid are deemed to be unstable and decompose to alcohol and carbon dioxide. In spite of this, we here report the isolation of the elusive carbonic acid monoethyl ester (CAEE) as a pure solid from ethanolic solutions of potassium bicarbonate. The hemiester is surprisingly stable in acidic solution and does not experience hydrolysis to carbonic acid. Furthermore, it is also stable in the gas phase, which we demonstrate by subliming the hemiester without decomposition. This could not be achieved in the past for any hemiester of carbonic acid...
April 21, 2017: RSC Advances
Xiaoyang Zhang, Yarong Liu, Yu Jeong Kim, John Mac, Rachel Zhuang, Pin Wang
Carboplatin (CPT) and paclitaxel (PTX) used in combination is one of the most effective treatments for ovarian cancer. However, the traditional combination methods used to co-administrate CPT and PTX showed limited clinical efficacy due to their distinct pharmacokinetics. Although much effort has been devoted to developing nanoparticles capable of encapsulating drugs with different lipophilicites, co-delivery of carboplatin with paclitaxel by a single nanoparticle has rarely been reported. Here, we encapsulated and delivered this drug combination to ovarian cancer cells at a controlled ratio by a previously reported crosslinked multilamellar liposome vesicle (cMLV)...
April 3, 2017: RSC Advances
Elyahb Allie Kwizera, Elise Chaffin, Yongmei Wang, Xiaohua Huang
Due to their high integrity, facile surface chemistry, excellent stability, and dual properties from the core and shell materials, magnetic-plasmonic core-shell nanoparticles are of great interest across a number of science, engineering and biomedical disciplines. They are promising for applications in a broad range of areas including catalysis, energy conversion, biological separation, medical imaging, disease detection and treatment. The technological applications have driven the need for high quality nanoparticles with well controlled magnetic and optical properties...
March 19, 2017: RSC Advances
Michael J Aldape, Aoxiang Tao, Dustin D Heeney, Eric R McIndoo, John M French, Dong Xu
Clostridium sordellii is a lethal pathogen for both animals and humans. Severe capillary leakage, toxic shock syndrome, and an extreme leukemoid reaction (LR), are hallmark features of C. sordellii infections and contribute to its high mortality rate. Here we report the discovery of a previously unknown and uncharacterized metalloproteinase of C. sordellii (referred as Mcs1) that cleaves human vascular cell adhesion molecule (VCAM)-1 in vitro, an adhesion molecule critical to hematopoietic precursor retention and leukocyte diapedesis...
March 2, 2017: RSC Advances
P M Pithan, D Decker, S I Druzhinin, H Ihmels, H Schönherr, Y Voß
Six new 8-styryl-substituted coralyne derivatives 4a-f were synthesized from coralyne (2) by a base catalysed Knoevenagel type reaction. It was shown by photometric and fluorimetric titrations of double stranded and quadruplex DNA to 4b-d as well as by fluorimetric DNA denaturation experiments that these ligands bind to DNA with different binding modes at varying ligand-DNA ratios (LDR). Specifically, the addition of DNA caused initially a hypochromic effect in absorbance and, at a particular LDR, the development of a new red shifted absorption band with a hyperchromic effect...
February 8, 2017: RSC Advances
Mengkai Li, Dong Wen, Zhimin Qiang, John Kiwi
This study presents the first evidence for the accelerated degradation of phenol by Fenton's reagent in a mini-fluidic VUV/UV photoreaction system (MVPS). A low-pressure mercury lamp used in the MVPS led to a complete degradation of phenol within 4-6 min. The HO˙ and HO2˙ originating from both Fenton's reagent and VUV photolysis of water were identified with suitable radical scavengers. The effects of initial concentrations of phenol, H2O2 and Fe(3+) as well as solution pH on phenol degradation kinetics were examined...
January 23, 2017: RSC Advances
V R S S Mokkapati, Derya Yuksel Koseoglu-Imer, Nurmiray Yilmaz-Deveci, Ivan Mijakovic, Ismail Koyuncu
A new and facile method for the fabrication of polysulfone-graphene oxide composite membranes is reported, where after casting, phase inversion is carried out with graphene oxide flakes (GO) in a coagulation bath. The membranes were characterized and the morphology was analysed using scanning electron microscopy. A bacterial inhibition ratio of 74.5% was observed with membranes fabricated from a very low concentration of di-water-GO non-solvent (0.048% of GO). The membranes were successfully tested for permeate flux and fouling resistance using activated sludge filtration from an MBR system...
January 16, 2017: RSC Advances
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