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RSC Advances

A Mohankumar, G Shanmugam, D Kalaiselvi, C Levenson, S Nivitha, G Thiruppathi, P Sundararaj
East Indian Sandalwood Oil (EISO) has diverse beneficial effects and has been used for thousands of years in traditional folk-medicine for treatment of different human ailments. However, there has been no in-depth scientific investigation to decipher the neuroprotective and geroprotective mechanism of EISO and its principle components, α- and β-santalol. Hence the current study was undertaken to assess the protective effects of EISO, and α- and β-santalol against neurotoxic (6-OHDA/6-hydroxydopamine) and proteotoxic (α-synuclein) stresses in a Caenorhabditis elegans model...
October 3, 2018: RSC Advances
Anjana Radhakrishnan, Christopher M Furze, Mohd Syed Ahangar, Elizabeth Fullam
One of the major obstacles to obtaining a complete structural and functional understanding of proteins encoded by the Mycobacterium tuberculosis ( Mtb ) pathogen is due to significant difficulties in producing recombinant mycobacterial proteins. Recent advances that have utilised the closely related Mycobacterium smegmatis species as a native host have been effective. Here we have developed a method for the rapid screening of both protein production and purification strategies of mycobacterial proteins in whole M...
September 27, 2018: RSC Advances
Ilia Villate-Beitia, Norman F Truong, Idoia Gallego, Jon Zárate, Gustavo Puras, José Luis Pedraz, Tatiana Segura
The lack of ideal non-viral gene carriers has motivated the combination of delivery systems and tissue-engineered scaffolds, which may offer relevant advantages such as enhanced stability and reduced toxicity. In this work, we evaluated a new combination between niosome non-viral vectors and hyaluronic acid (HA) hydrogel scaffolds, both widely studied due to their biocompatibility as well as their ability to incorporate a wide variety of molecules. We evaluated three different niosome formulations (niosomes 1 , 2 and 3 ) varying in composition of cationic lipid, helper lipid and non-ionic tensioactives...
September 17, 2018: RSC Advances
Michael Chin, Cecilia Cisneros, Stephanie M Araiza, Kevin M Vargas, Kristi M Ishihara, Fangyuan Tian
Adsorption and photodegradation of rhodamine B by ZIF-8 nanocrystals were studied using spectroscopic techniques coupled with density functional theory (DFT) cluster calculations. A fast adsorption rate was observed in the dark, but upon exposure to visible light or UV irradiation the adsorption rate noticeably increased. Although several studies previously reported this phenomenon involving bulk ZIF-8 powder, this is the first mechanistic study to our knowledge that demonstrates adsorption and degradation of rhodamine B by nanosized ZIF-8 under various light conditions...
July 29, 2018: RSC Advances
Peng Zhu, Carl Atkinson, Suraj Dixit, Qi Cheng, Danh Tran, Kunal Patel, Yu-Lin Jiang, Scott Esckilsen, Kayla Miller, Grace Bazzle, Patterson Allen, Alfred Moore, Ann-Marie Broome, Satish N Nadig
Hypothermic preservation is the standard of care for storing organs prior to transplantation. Endothelial and epithelial injury associated with hypothermic storage causes downstream graft injury and, as such, the choice of an ideal donor organ preservation solution remains controversial. Cold storage solutions, by design, minimize cellular necrosis and optimize cellular osmotic potential, but do little to assuage immunological cell activation or immune cell priming post transplantation. Thus, here we explore the efficacy of our previously described novel Targeted Rapamycin Micelles (TRaM) as an additive to standard-of-care University of Wisconsin preservation solution as a means to alter the immunological microenvironment post transplantation using in vivo models of tracheal and aortic allograft transplantation...
July 23, 2018: RSC Advances
Joydeb Mandal, R S Varunprasaath, Wenqing Yan, Mohammad Divandari, Nicholas D Spencer, Matthias Dübner
An investigation of the polymerisation of 2-hydroxyethyl methacrylate (HEMA) by means of surface-initiated atom transfer radical polymerisation (SI-ATRP) has been carried out in situ using a quartz crystal microbalance, with multiple reinitiations under continuous flow of the reaction mixture. The SI-ATRP kinetics of HEMA were studied continuously by means of changes in the frequency, varying conditions including temperature and solvent composition, as well as monomer and catalyst concentrations, showing the influence of key reaction parameters on SI-ATRP kinetics...
June 3, 2018: RSC Advances
Kokkarachedu Varaprasad, Dariela Nunez, Murali Mohan Yallapu, Tippabattini Jayaramudu, Elizabeth Elgueta, Patricio Oyarzun
Herein, two kinds of nano-hydroxyapatite were synthesized from Clam and Magellan shell by wet chemical precipitation method. Mainly, carboxymethyl cellulose/acrylamide/nano-hydroxyapatite composite hydrogels were developed via a free-radical polymerization process and investigated as a sorbent for Acid Blue 113 (AB) from aqueous AB solution. The swelled and kinetic behaviours of hydrogels were investigated using a gravimetric method. The swelling properties of the CMC-AM-hydrogels were influenced by the calcium electrolytes (Ca2+ ) content in nano-hydroxyapatites...
May 16, 2018: RSC Advances
Edyta Niezabitowska, Jessica Smith, Mark R Prestly, Riaz Akhtar, Felix W von Aulock, Yan Lavallée, Hanene Ali-Boucetta, Tom O McDonald
The geometries and surface properties of nanocarriers greatly influence the interaction between nanomaterials and living cells. In this work we combine multiwalled carbon nanotubes (CNTs) with poly-ε-caprolactone (PCL) to produce non-spherical nanocomposites with high aspect ratios by using a facile emulsion solvent evaporation method. Particles were characterised by dynamic light scattering (DLS), scanning electron microscopy (SEM), atomic force microscopy (AFM) and asymmetric flow field flow fractionation (AF4)...
May 7, 2018: RSC Advances
Caroline Kearney, Lukasz T Olenginski, Trexler D Hirn, Gwendolyn D Fowler, Daniyal Tariq, Scott H Brewer, Christine M Phillips-Piro
The vibrational reporter unnatural amino acid (UAA) 4-cyano-l-phenylalanine (pCNF) was genetically incorporated individually at three sites (5, 36, and 78) in the heme protein Caldanaerobacter subterraneus H-NOX to probe local hydration environments. The UAA pCNF was incorporated site-specifically using an engineered, orthogonal tRNA synthetase in E. coli . The ability of all of the pCNF-containing H-NOX proteins to form the ferrous CO, NO, or O2 ligated and unligated states was confirmed with UV-Vis spectroscopy...
April 9, 2018: RSC Advances
Liandong Jing, Yanbo Tang, Masuo Goto, Kuo-Hsiung Lee, Zhiyan Xiao
Cyclin-dependent kinases (CDKs) are pivotal kinases in cell cycle transition and gene transcription. A series of N 2 , N 4 -diphenylpyrimidine-2,4-diamines were previously identified as potent CDK2/CDK9 inhibitors. To explore the SAR of this structural prototype, twenty-four novel N 2 , N 4 -disubstituted pyrimidine-2,4-diamines were designed and synthesized. Among them, twenty-one compounds exhibited potent inhibitory activities against both CDK2/cyclin A and CDK9/cyclin T1 systems, and the most potent CDK2 and CDK9 inhibitors, 3g and 3c , showed IC50 values of 83 nM and 65 nM respectively...
April 2, 2018: RSC Advances
Zewdu M Gebeyehu, Aloïs Arrighi, Marius V Costache, Clivia M Sotomayor-Torres, Maria J Esplandiu, Sergio O Valenzuela
Exposing graphene to a hydrogen post-etching process yields dendritic graphene shapes. Here, we demonstrate that similar dendritic structures can be achieved at long growth times without adding hydrogen externally. These shapes are not a result of a surface diffusion controlled growth but of the competing backward reaction (etching), which dominates the growth dynamics at long times due to an in situ rise in the hydrogen partial pressure. We have performed a systematic study on the growth of graphene as a function of time to identify the onset and gradual evolution of graphene shapes caused by etching and then demonstrated that the etching can be stopped by reducing the flow of hydrogen from the feed...
February 22, 2018: RSC Advances
Roland Thuenauer, Simon Nicklaus, Marco Frensch, Kevin Troendle, Josef Madl, Winfried Römer
A key factor determining the fate of individual cells within an epithelium is the unique microenvironment that surrounds each cell. It regulates location-dependent differentiation into specific cellular sub-types, but, on the other hand, a disturbed microenvironment can promote malignant transformation of epithelial cells leading to cancer formation. Here, we present a tool based on a microfluidic biochip that enables novel research approaches by providing a means to control the basolateral microenvironment of a confined number of neighbouring cells within an epithelial monolayer...
February 19, 2018: RSC Advances
Alexandra Iordachescu, Philippa Hulley, Liam M Grover
Nanovesicles, exosomes and other membrane bound particles excreted by cells are currently gaining research attention since they have been shown to play a significant role in many biologically related processes. Vesicles are now thought to mediate cellular communication, transmission of some diseases and pathologically mediated calcification. Matrix vesicles have long been proposed to be central to the controlled mineralisation of bone. They remain relatively poorly studied, however, since they are challenging to extract from biological media...
February 13, 2018: RSC Advances
Muhammad Waqas Khalid, Rajib Ahmed, Ali K Yetisen, Haider Butt
Optical sensors for detecting temperature and strain play a crucial role in the analysis of environmental conditions and real-time remote sensing. However, the development of a single optical device that can sense temperature and strain simultaneously remains a challenge. Here, a flexible corner cube retroreflector (CCR) array based on passive dual optical sensing (temperature and strain) is demonstrated. A mechanical embossing process was utilised to replicate a three-dimensional (3D) CCR array in a soft flexible polymer film...
February 13, 2018: RSC Advances
Arantxa Fernandes, Robert F Moran, Scott Sneddon, Daniel M Dawson, David McKay, Giulia P M Bignami, Frédéric Blanc, Karl R Whittle, Sharon E Ashbrook
The potential of 17 O NMR spectroscopy for the investigation of A2 B2 O7 ceramic oxides important in the encapsulation of radioactive waste is demonstrated, with post-synthetic enrichment by exchange with 17 O2 gas. For Y2 Sn2 O7 , Y2 Ti2 O7 and La2 Sn2 O7 pyrochlores, enrichment of the two distinct O species is clearly non quantitative at lower temperatures (∼700 °C and below) and at shorter times, despite these being used in prior work, with preferential enrichment of OA2 B2 favoured over that of OA4 ...
February 13, 2018: RSC Advances
N Ganot, E Y Tshuva
Advanced anticancer phenolato titanium(iv) complexes were combined with known chemotherapeutic anticancer drugs applied in the clinic and were analyzed in vitro on cell lines most sensitive to the Ti(iv) complex and relevant to the clinical application of the known drugs. Combination of the Ti(iv) complex with cisplatin on ovarian cells showed mostly an additive behavior, also on a line resistant to cisplatin. Combination of the Ti(iv) complex with fluorouracil on colon cells gave near additive behavior, and that with oxaliplatin gave a synergistic behavior at a wide range of Ti : Pt ratios, but only when the drugs were administered together...
February 5, 2018: RSC Advances
Khang Hoang, Myungkeun Oh, Yongki Choi
Transition-metal tungstates MWO4 (M = Co, Ni, Cu, Zn) have applications in many areas, including supercapacitors. A good understanding of the electronic structure is essential to understanding their functional properties. Here, we report a first-principles study of the materials using hybrid density-functional calculations. The electronic structure is analyzed with a focus on the nature of the electronic states near the band edges. We find that hole polarons can form at the Co lattice site in CoWO4 and the O site in NiWO4 , CuWO4 , and ZnWO4 , resulting in the formation of Co3+ in the former and O- in the latter...
January 23, 2018: RSC Advances
Ian Seungwan Ryu, Xiaohui Liu, Ying Jin, Jirun Sun, Young Jong Lee
We quantitatively analyze multiple hydrogen bonds in mixtures of two monomers: urethane dimethacrylate (UDMA) and triethylene glycol-divinylbenzyl ether (TEG-DVBE). The carbonyl stretching band in infrared (IR) absorption spectra is deconvoluted into free and hydrogen-bonded carbonyl groups. The amounts of the sub-components are determined for 21 mixture compositions and initially analyzed using a simple stoichiometric model (based on one dominant hydrogen acceptor group per monomer species) for the equilibrium state of hydrogen bond formation...
2018: RSC Advances
Theodore Christoforidis, Tom G Driver, Jalees Rehman, David T Eddington
Hydrogen sulfide (H2 S) plays an important role as an intercellular and intracellular signaling molecule, yet its targets are not well understood. As a molecule it easily evaporates and it is hard to acquire stable concentration for in vitro studies, constituting a major problem for the field to identify its downstream targets and function. Here we develop a microfluidic system that can provide consistent and controllable H2 S levels in contrast to the current method of delivering large bolus doses to cells...
2018: RSC Advances
C G Uhl, Y Gao, S Zhou, Y Liu
Nanoparticle therapeutic delivery is influenced by many factors including physical, chemical, and biophysical properties along with local vascular conditions. In recent years, nanoparticles of various shapes have been fabricated and have shown significant impact on transport efficiency. Identification of which nanoparticle shape helps to improve the therapeutic delivery process allows for enhanced therapeutic effects, yet is hard to be quantified in vivo due to the complex nature of the in vivo environment...
2018: RSC Advances
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