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International Journal of Burns and Trauma

Gregory S Huang, C Michael Dunham
The value of prehospital red blood cell (RBC) transfusion for trauma patients is controversial. The purposes of this literature review were to determine the mortality rate of trauma patients with hemodynamic instability and the benefit of prehospital RBC transfusion. A 30-year systematic literature review was performed in 2016. Eligible studies were combined for meta-analysis when tests for heterogeneity were insignificant. The synthesized mortality was 35.6% for systolic blood pressure ≤ 90 mmHg; 51.1% for ≤ 80 mmHg; and 63...
2017: International Journal of Burns and Trauma
Yanhan Ren, Philip Chang, Robert L Sheridan
INTRODUCTION: Negative Pressure Wound Therapy (NPWT) has proven to be a powerful tool in facilitating healing of difficult wounds of a variety of etiologies. The pediatric experience with NPWT has been limited due to concerns about vascular compression and pain associated with treatment. METHOD: A retrospective review was performed to evaluate the therapeutic effect of NPWT on children with difficult wounds due to burns or soft-tissue trauma. NPWT was instituted in the operating room under general anesthesia using a commercially available system...
2017: International Journal of Burns and Trauma
Moustafa Elmasry, Ingrid Steinvall, Johan Thorfinn, Islam Abdelrahman, Pia Olofsson, Folke Sjoberg
BACKGROUND: Different surgical techniques have evolved since excision and autografting became the treatment of choice for deep burns in the 1970s. The treatment plan at the Burn Center, Linköping University Hospital, Sweden, has shifted from single-stage excision and immediate autografting to staged excisions and temporary cover with xenografts before autografting. The aim of this study was to find out if the change in policy resulted in extended duration of hospital stay/total body surface area burned (LOS/TBSA%)...
2017: International Journal of Burns and Trauma
Alisha Z Jiwani, James F Williams, Julie A Rizzo, Kevin K Chung, Booker T King, Leopoldo C Cancio
E-cigarettes are typically lithium-ion battery-operated devices that simulate smoking by heating a nicotine-solution into a vapor that the user inhales. E-cigarette use is becoming rapidly popular as an alternative to traditional cigarette smoking. This report describes an emerging problem associated with e-cigarettes, consisting of 10 thermally injured patients seen at a single burn center over a 2-year period from 2014 to 2016. Our cohort was comprised mainly of young adults who sustained mixed partial and full thickness burns as a result of e-cigarette-related explosions...
2017: International Journal of Burns and Trauma
Desmond D Mascarenhas, Amina El Ayadi, Michael Wetzel, Anesh Prasai, Randy Mifflin, Jayson Jay, David N Herndon, Celeste C Finnerty
The mechanisms underlying the effects of severe burn trauma are not well understood. We previously demonstrated the ability of nephrilin peptide (an iron-binding peptide believed to enter cells through iron-uptake pathways) to suppress aspects of the neuroinflammatory response in a rat scald model, as well as sepsis mortality in a mouse model. This study explores the effect of nephrilin on other clinically relevant outcomes in the rat scald model. In a rat scald model, animals were treated with nephrilin either in week 1 or week 2 post-burn...
2016: International Journal of Burns and Trauma
Heber Bombang Sapan, Idrus Paturusi, Irawan Jusuf, Ilhamjaya Patellongi, Muh Nasrum Massi, Aryono Djuned Pusponegoro, Syafrie Kamsul Arief, Ibrahim Labeda, Andi Asadul Islam, Leo Rendy, Mochammad Hatta
Massive injury remains the most common cause of death for productive age group globally. The current immune, inflammatory paradigm, based on an incomplete understanding of the functional integration of the complex host response, remains a major impediment to the development of effective innovative diagnostic and therapeutic effort. This study attempt to investigate the pattern of inflammatory and anti-inflammatory cytokines such as interleukin-6 and 10 (IL-6 and IL-10) and their interaction in severe injury condition with its major complication as multiple organ dysfunction syndrome (MODS) and failure (MOF) after polytrauma...
2016: International Journal of Burns and Trauma
Saud Othman Al Shlash, Jamal Omran Al Madani, Jamal Ismail El Deib, Fatemah Suliman Alsubhi, Sara Saud Al Saifi, Ayman Mohammed Adel Helmi, Sultan Khalaf Al-Mutairi, Javed Akhtar Khurram
Split thickness skin graft (STSG) and full thickness skin graft (FTSG) are the integral part of burn wound management. However the impact of these graft types on the outcome still remain a matter of controversy. The purpose of this study was to determine the demographic characteristics and outcome of graft surgery of the patients undergone STSG and FTSG at Plastic Surgery Department of Prince Sultan Military Medical City (PSMMC), Riyadh, Kingdom of Saudi Arabia. This retrospective study included 85 burn patients who received STSG (56 cases) and FTSG (29 cases) at PSMMC during 2010-2015...
2016: International Journal of Burns and Trauma
Seema Menon, Queenie Chan, Monique Bertinetti, John G Harvey, Erik R La Hei, Andrew Ja Holland
We conducted this study to evaluate a novel device to create a consistent and reproducible deep partial thickness burn in a porcine model. A thermostatically controlled, heated aluminium disc device was fashioned by the Biomedical Department of our institution. Contact burns were made on the flank of two Great White pigs by applying the device heated to 92°C at intervals of 5, 10, 15 and 20 seconds to four separate test areas area of skin. Biopsies for histological analysis of burn depth were taken on day 0 at 10 minutes post burn and on day 8...
2016: International Journal of Burns and Trauma
Rohit Rao, Qian Yang, Mehmet A Orman, Francois Berthiaume, Marianthi G Ierapetritou, Ioannis P Androulakis
Circadian rhythms play an important role in maintaining homeostasis and solid organ function. The purpose of this study is to assess the implications of burn injury in rats on the underlying circadian patterns of gene expression in liver. Circadian-regulated genes and burn-induced genes were identified by applying consensus clustering methodology to temporally differentially expressed probe sets obtained from burn and sham-burn data sets. Of the liver specific genes which we hypothesize that exhibit circadian rhythmicity, 88% are not differentially expressed following the burn injury...
2016: International Journal of Burns and Trauma
(no author information available yet)
[This retracts the article on p. 31 in vol. 4, PMID: 24624312.].
2016: International Journal of Burns and Trauma
Antonio Mendoza, Fernando L Santoyo, Alberto Agulló, José L Fenández-Cañamaque, Carmen Vivó
OBJECTIVE: To describe the management of pain prevention associated with burn care. METHODS: Multi-centre, observational, cross-sectional, descriptive study performed in 4 burn units in Spain. RESULTS: A total of 55 patients undergoing 64 procedures were analysed. Burns were classified as severe (90.4%), third-degree (78.2%) and caused by thermal agents (81.8%). Background analgesia consisted of non-opioid drugs (87.5%) and opioids (54.7%) [morphine (20...
2016: International Journal of Burns and Trauma
Didier Moissenet, Patrick Richard, Maria Granados, Audrey Mérens, Damien Fournier, Marguerite Fines-Guyon, Guillaume Arlet, Hoang Vu-Thien
A 5 years-old girl, seriously burnt with fire, was first hospitalized during four days in an hospital at Alger, and then transferred to our hospital at Paris. Admitted in our intensive care burns unit, she was third degree burnt on 78% of total body surface area, already treated with imipenem and vancomycin at her arrival. Clinical aggravation was rapidly observed and death occurred within 24 hours. Cultures of blood and multiple wound swabs yielded 3 multi-drug resistant bacterial strains: Acinetobacter baumannii with carbapenemase OXA-23, Pseudomonas aeruginosa serotype O11 with metallo-ß-lactamase VIM-4 and Klebsiella pneumoniae with CTX-M-15 extended-spectrum ß-lactamase...
2015: International Journal of Burns and Trauma
Takuya Naganawa, Hidemasa Murozumi, Abhishek Kumar, Atsushi Okuyama, Toshihiro Okamoto, Tomohiro Ando
We describe the case of a 77 year-old Japanese woman who was referred to the Department of Oral and Maxillofacial Surgery at Tokyo Women's Medical University Hospital with symptoms of spontaneous intraoral pain and dysphagia evoked by accidental alkaline (calcium oxide) ingestion. The stomach and esophagus were examined under endoscopy, but no evidence of burns or ulceration associated with the calcium oxide was apparent in the upper gastrointestinal tract. Oral care, antibacterial therapy (cefmetazole sodium) and nutritional management were performed after hospitalization...
2015: International Journal of Burns and Trauma
Metin Gündüz, İlhan Çiftçi, Tamer Sekmenli
INTRODUCTION: In Konya, Turkey, the community celebrates the traditional ceremony of Shivlilik, which occurs on the first day of the seventh month in the lunar-based Hijri calendar. In the evening, people light bonfires of tires in the streets, and children and young people attempt to jump over the flames. Flame burns regularly occur due to falling. Attention should be given to preventing injuries such as these that are caused by social and regional customs. METHODS: This retrospective study was carried out using data from the Konya Education and Research Hospital Burn Unit...
2015: International Journal of Burns and Trauma
Slava M Belenkiy, William L Baker, Andriy I Batchinsky, Sumit Mittal, Taylor Watkins, Jose Salinas, Leopoldo C Cancio
PURPOSE: End-tidal CO2 (eTCO2) can be used to estimate the arterial CO2 (PaCO2) under steady-state conditions, but that relationship deteriorates during hemodynamic or respiratory instability. We developed a multivariate method to improve our ability to estimate the PaCO2, by using additional information contained in the volumetric capnograph (Vcap) waveform. We tested this approach using data from a porcine model of chest trauma/hemorrhage. METHODS: This experiment consisted of 3 stages: pre-injury, injury/resuscitation, and post-injury...
2015: International Journal of Burns and Trauma
Richard F Oppeltz, Travis L Holloway, Cody J Covington, Martin G Schwacha
Trauma-related pain is a natural consequence of injury and its surgical management; however, the relationship between opiates and complications in trauma patients is unknown. To study this a retrospective chart review of selected subjects following traumatic injury with admission to the SICU for > 3 days was performed, and opiate administration data was collected for the first 3 days of admission. Associated data from each subject's chart was also collected. Analysis of the data revealed that increased opiate intake after admission to the SICU was associated with significantly increased SICU and hospital LOS independent of injury severity...
2015: International Journal of Burns and Trauma
C Michael Dunham, Barbara M Hileman, Kenneth J Ransom, Rema J Malik
OBJECTIVE: We hypothesized that lung injury and rib cage fracture quantification would be associated with adverse outcomes. SUBJECTS AND METHODS: Consecutive admissions to a trauma center with Injury Severity Score ≥ 9, age 18-75, and blunt trauma. CT scans were reviewed to score rib and sternal fractures and lung infiltrates. Sternum and each anterior, lateral, and posterior rib fracture was scored 1 = non-displaced and 2 = displaced. Rib cage fracture score (RCFS) = total rib fracture score + sternal fracture score + thoracic spine Abbreviated Injury Score (AIS)...
2015: International Journal of Burns and Trauma
Sam Jacob, Yong Zhu, Robert Kraft, Christopher Cotto, Joseph R Carmical, Thomas G Wood, Perenlei Enkhbaatar, David N Herndon, Hal K Hawkins, Robert A Cox
Pneumonia is the leading complication in the critical care of burn victims. Airway epithelial dysfunction compromises host defense against pneumonia. The aim of this study is to test the hypothesis that burn injury alters the physiology of the airway epithelium. A rat model of 60% TBSA third degree scald burn was used. At 24 hours after injury, tracheal epithelial ultrastructure was studied using transmission electron microscopy (TEM) and proliferation was measured by Ki67 immunohistochemistry. Mucociliary clearance (MCC) was measured using fluorescent microspheres...
2015: International Journal of Burns and Trauma
David Sadowsky, Gary Nieman, Derek Barclay, Qi Mi, Ruben Zamora, Gregory Constantine, Lorne Golub, Hsi-Ming Lee, Shreyas Roy, Louis A Gatto, Yoram Vodovotz
Sepsis can lead to multiple organ dysfunction, including the Acute Respiratory Distress Syndrome (ARDS), due to intertwined, dynamic changes in inflammation and organ physiology. We have demonstrated the efficacy of Chemically-Modified Tetracycline 3 (CMT-3) at reducing inflammation and ameliorating pathophysiology in the setting of a clinically realistic porcine model of ARDS. Here, we sought to gain insights into the derangements that characterize sepsis/ARDS and the possible impact of CMT-3 thereon, by combined experimental and computational studies...
2015: International Journal of Burns and Trauma
Ioannis Goutos, Rebecca Spenser Nicholas, Atisha A Pandya, Sudip J Ghosh
Diabetes mellitus is an increasingly prevalent comorbidity in patients presenting to burn facilities. Diabetic patients tend to be older and present in a delayed manner with deeper injuries predominantly affecting the lower limb. Morbidity from burns is higher in this cohort including a longer length of hospital stay, greater need for surgical interventions and increased rate of infective complications. Nevertheless, there seems to be little effect of diabetes on associated mortality. The second part of this review article concentrates on the epidemiological profile of diabetic burn patients and the effect of the disease on morbidity and mortality...
2015: International Journal of Burns and Trauma
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