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Advanced Healthcare Materials

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https://www.readbyqxmd.com/read/30658015/macrophage-and-fibroblast-interactions-in-biomaterial-mediated-fibrosis
#1
REVIEW
Claire E Witherel, Daniel Abebayehu, Thomas H Barker, Kara L Spiller
Biomaterial-mediated inflammation and fibrosis remain a prominent challenge in designing materials to support tissue repair and regeneration. Despite the many biomaterial technologies that have been designed to evade or suppress inflammation (i.e., delivery of anti-inflammatory drugs, hydrophobic coatings, etc.), many materials are still subject to a foreign body response, resulting in encapsulation of dense, scar-like extracellular matrix. The primary cells involved in biomaterial-mediated fibrosis are macrophages, which modulate inflammation, and fibroblasts, which primarily lay down new extracellular matrix...
January 18, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30657652/immunostimulatory-effects-triggered-by-self-assembled-microspheres-with-tandem-repeats-of-polymerized-rna-strands
#2
Dajeong Kim, Hyejin Kim, Sangwoo Han, Marta Scatena, Deok-Ho Kim, Jong Bum Lee
Self-assembled RNA particles have been exploited widely to maximize the therapeutic potential of RNA. However, the immune response via RNA particles is not fully understood. In addition, the investigation of the immunogenicity from RNA-based particles is required owing to inherent immunostimulatory effects of RNA for clinical translation. To examine the immune stimulating potency, rationally designed microsized RNA particles, called RNA microspheres (RMSs), are generated with single or double strands via rolling circle transcription...
January 18, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30645055/nitric-oxide-therapy-for-diabetic-wound-healing
#3
REVIEW
Maggie J Malone-Povolny, Sara E Maloney, Mark H Schoenfisch
Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous reservoirs, and supplementing NO from exogenous sources. This progress report examines the efficacy of a variety of NO-based methods to improve wound outcomes, with particular attention given to diabetes-associated chronic wounds.
January 15, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30645037/magnet-patterned-superparamagnetic-fe-3-o-4-au-core-shell-nanoplasmonic-sensing-array-for-label-free-high-throughput-cytokine-immunoassay
#4
Yuxin Cai, Jingyi Zhu, Jiacheng He, Wen Yang, Chao Ma, Feng Xiong, Feng Li, Weiqiang Chen, Pengyu Chen
Rapid and accurate immune monitoring plays a decisive role in effectively treating immune-related diseases especially at point-of-care, where an immediate decision on treatment is needed upon precise determination of the patient immune status. Derived from the emerging clinical demands, there is an urgent need for a cytokine immunoassay that offers unprecedented sensor performance with high sensitivity, throughput, and multiplexing capability, as well as short turnaround time at low system complexity, manufacturability, and scalability...
January 15, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30644660/a-magnetically-assembled-high-aspect-ratio-needle-electrode-for-recording-neuronal-activity
#5
Taiki Yasui, Shota Yamagiwa, Hirohito Sawahata, Shinnosuke Idogawa, Yoshihiro Kubota, Yuto Kita, Koji Yamashita, Rika Numano, Kowa Koida, Takeshi Kawano
Microelectrode devices, which enable the detection of neuronal signals in brain tissues, have made significant contributions in the field of neuroscience and the brain-machine interfaces. To further develop such microelectrode devices, the following requirements must be met: i) a fine needle's diameter (<30 µm) to reduce damage to tissues; ii) a long needle (e.g., ≈1 mm for rodents and ≈2 mm for macaques); and iii) multiple electrodes to achieve high spatial recording (<100 µm in pitch). In order to meet these requirements, this study herein reports an assembly technique for high-aspect-ratio microneedles, which employs a magnet...
January 15, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30637979/3d-electrophysiological-measurements-on-cells-embedded-within-fiber-reinforced-matrigel
#6
Natascha Schaefer, Dieter Janzen, Ezgi Bakirci, Andrei Hrynevich, Paul D Dalton, Carmen Villmann
2D electrophysiology is often used to determine the electrical properties of neurons. In the brain however, neurons form extensive 3D networks. Thus, performing electrophysiology in a 3D environment provides a closer situation to the physiological condition and serves as a useful tool for various applications in the field of neuroscience. In this study, 3D electrophysiology is established within a fiber-reinforced matrix to enable fast readouts from transfected cells, which are often used as model systems for 2D electrophysiology...
January 13, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30633858/near-infrared-light-activatable-nanoparticles-for-deep-tissue-penetrating-wireless-optogenetics
#7
REVIEW
Nuo Yu, Ling Huang, Yubin Zhou, Tian Xue, Zhigang Chen, Gang Han
Optogenetics has been developed to control the activities and functions of cells with high spatiotemporal resolution, cell-type specificity, and flexibility. However, current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues. This often results in a series of side effects, such as tissue damage and unwanted inflammation. Fortunately, the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms...
January 11, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30633854/layer-by-layer-cerium-oxide-nanoparticle-coating-for-antioxidant-protection-of-encapsulated-beta-cells
#8
Nicholas J Abuid, Kerim M Gattás-Asfura, Emily A Schofield, Cherie L Stabler
In type 1 diabetes, the replacement of the destroyed beta cells could restore physiological glucose regulation and eliminate the need for exogenous insulin. Immunoisolation of these foreign cellular transplants via biomaterial encapsulation is widely used to prevent graft rejection. While highly effective in blocking direct cell-to-cell contact, nonspecific inflammatory reactions to the implant lead to the overproduction of reactive oxygen species, which contribute to foreign body reaction and encapsulated cell loss...
January 11, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30633852/development-of-a-coaxial-3d-printing-platform-for-biofabrication-of-implantable-islet-containing-constructs
#9
Xiao Liu, Sarah-Sophia D Carter, Max Jurie Renes, Juewan Kim, Darling Macarena Rojas-Canales, Daniella Penko, Cameron Angus, Stephen Beirne, Christopher John Drogemuller, Zhilian Yue, Patrick T Coates, Gordon G Wallace
Over the last two decades, pancreatic islet transplantations have become a promising treatment for Type I diabetes. However, although providing a consistent and sustained exogenous insulin supply, there are a number of limitations hindering the widespread application of this approach. These include the lack of sufficient vasculature and allogeneic immune attacks after transplantation, which both contribute to poor cell survival rates. Here, these issues are addressed using a biofabrication approach. An alginate/gelatin-based bioink formulation is optimized for islet and islet-related cell encapsulation and 3D printing...
January 11, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30632715/designing-next-generation-local-drug-delivery-vehicles-for-glioblastoma-adjuvant-chemotherapy-lessons-from-the-clinic
#10
REVIEW
Anthony Tabet, Melanie P Jensen, Christopher C Parkins, Parag G Patil, Colin Watts, Oren A Scherman
To date, the clinical outcomes and survival rates for patients with glioblastoma (GB) remain poor. A promising approach to disease-modification involves local delivery of adjuvant chemotherapy into the resection cavity, thus circumventing the restrictions imposed by the blood-brain barrier. The clinical performance of the only FDA-approved local therapy for GB [carmustine (BCNU)-loaded polyanhydride wafers], however, has been disappointing. There is an unmet medical need in the local treatment of GB for drug delivery vehicles that provide sustained local release of small molecules and combination drugs over several months...
January 11, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30632706/replacement-of-rat-tracheas-by-layered-trachea-like-scaffold-free-structures-of-human-cells-using-a-bio-3d-printing-system
#11
Ryusuke Machino, Keitaro Matsumoto, Daisuke Taniguchi, Tomoshi Tsuchiya, Yosuke Takeoka, Yasuaki Taura, Masaaki Moriyama, Tomoyuki Tetsuo, Shosaburo Oyama, Katsunori Takagi, Takuro Miyazaki, Go Hatachi, Ryoichiro Doi, Koichiro Shimoyama, Naoto Matsuo, Naoya Yamasaki, Koichi Nakayama, Takeshi Nagayasu
Current scaffold-based tissue engineering approaches are subject to several limitations, such as design inflexibility, poor cytocompatibility, toxicity, and post-transplant degradation. Thus, scaffold-free tissue-engineered structures can be a promising solution to overcome the issues associated with classical scaffold-based materials in clinical transplantation. The present study seeks to optimize the culture conditions and cell combinations used to generate scaffold-free structures using a Bio-3D printing system...
January 11, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30624860/silk-protein-bioresorbable-drug-eluting-ear-tubes-proof-of-concept
#12
Sarah A Bradner, Deepa Galaiya, Nikhila Raol, David L Kaplan, Chistopher J Hartnick
Otitis media with effusion (OEM) is a common pediatric pathology treated with topical fluoroquinolones (ear drops) and tympanoplasty tube, also referred to as ear tube, implantation for middle ear drainage. Commercially available ear tubes are fabricated using poly (lactic-co-glycolic acid) synthetic materials that are associated with long-complications due to premature extrusion. Resorbable materials have emerged as desirable alternatives to reduce extrusion-related complications, but often limited by fast resorption rates...
January 9, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30624015/fiber-reinforced-cartilage-ecm-functionalized-bioinks-for-functional-cartilage-tissue-engineering
#13
Swetha Rathan, Léa Dejob, Rossana Schipani, Benjamin Haffner, Matthias E Möbius, Daniel J Kelly
Focal articular cartilage (AC) defects, if left untreated, can lead to debilitating diseases such as osteoarthritis. While several tissue engineering strategies have been developed to promote cartilage regeneration, it is still challenging to generate functional AC capable of sustaining high load-bearing environments. Here, a new class of cartilage extracellular matrix (cECM)-functionalized alginate bioink is developed for the bioprinting of cartilaginous tissues. The bioinks are 3D-printable, support mesenchymal stem cell (MSC) viability postprinting and robust chondrogenesis in vitro, with the highest levels of COLLII and ACAN expression observed in bioinks containing the highest concentration of cECM...
January 9, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30620448/atheroma-niche-responsive-nanocarriers-for-immunotherapeutic-delivery
#14
Erica B Peters, Nick D Tsihlis, Mark R Karver, Stacey M Chin, Bruno Musetti, Benjamin T Ledford, Edward M Bahnson, Samuel I Stupp, Melina R Kibbe
Nanomedicine is a promising, noninvasive approach to reduce atherosclerotic plaque burden. However, drug delivery is limited without the ability of nanocarriers to sense and respond to the diseased microenvironment. In this study, nanomaterials are developed from peptide amphiphiles (PAs) that respond to the increased levels of matrix metalloproteinases 2 and 9 (MMP2/9) or reactive oxygen species (ROS) found within the atherosclerotic niche. A pro-resolving therapeutic, Ac2-26, derived from annexin-A1 protein, is tethered to PAs using peptide linkages that cleave in response to MMP2/9 or ROS...
January 8, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30614638/oil-core-peg-shell-nanocarriers-for-in-vivo-mri-imaging
#15
Vincenzo Calcagno, Raffaele Vecchione, Vincenzo Quagliariello, Pasquina Marzola, Alice Busato, Pierangela Giustetto, Martina Profeta, Sara Gargiulo, Chiara Di Cicco, Hui Yu, Marco Cassani, Nicola Maurea, Marcello Mancini, Teresa Pellegrino, Paolo A Netti
Oil-in-water emulsions represent a promising carrier for in vivo imaging because of the possibility to convey poorly water-soluble species. To promote accumulation at the tumor site and prolong circulation time, reduction of carrier size and surface PEGylation plays a fundamental role. In this work a novel, simple method to design an oil-core/PEG-shell nanocarrier is reported. A PEG-shell is grown around a monodisperse oil-in-water nanoemulsion with a one-pot method, using the radical polymerization of poly(ethylene glycol)diacrylate...
January 7, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30614636/unraveling-the-mechanobiology-of-the-immune-system
#16
REVIEW
Jeong-Ki Kim, Yu Jung Shin, Leslie Jaesun Ha, Deok-Ho Kim, Dong-Hwee Kim
Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary...
January 7, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30609312/cardiac-fibrotic-remodeling-on-a-chip-with-dynamic-mechanical-stimulation
#17
Ming Kong, Junmin Lee, Iman K Yazdi, Amir K Miri, Yi-Dong Lin, Jungmok Seo, Yu Shrike Zhang, Ali Khademhosseini, Su Ryon Shin
Cardiac tissue is characterized by being dynamic and contractile, imparting the important role of biomechanical cues in the regulation of normal physiological activity or pathological remodeling. However, the dynamic mechanical tension ability also varies due to extracellular matrix remodeling in fibrosis, accompanied with the phenotypic transition from cardiac fibroblasts (CFs) to myofibroblasts. It is hypothesized that the dynamic mechanical tension ability regulates cardiac phenotypic transition within fibrosis in a strain-mediated manner...
January 4, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30609270/recruitment-and-collection-of-dermal-interstitial-fluid-using-a-microneedle-patch
#18
Chandana Kolluru, Mikayla Williams, Jeremy Chae, Mark R Prausnitz
Interstitial fluid (ISF) that surrounds cells in tissues of the body is a novel source of biomarker that complements conventional sources like blood, urine, and saliva. To overcome difficulties in harvesting ISF, a minimally invasive, rapid, simple-to-use, cost-effective method is developed to collect ISF from the skin involving a microneedle (MN) patch. By pressing 650 µm long MNs at an angle just below the skin surface, blood-free ISF flows through micropores to the skin surface and is absorbed into a thin strip of paper on the MN patch backing for subsequent analysis...
January 4, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30609261/responsive-and-synergistic-antibacterial-coatings-fighting-against-bacteria-in-a-smart-and-effective-way
#19
REVIEW
Ting Wei, Qian Yu, Hong Chen
Antibacterial coatings that eliminate initial bacterial attachment and prevent subsequent biofilm formation are essential in a number of applications, especially implanted medical devices. Although various approaches, including bacteria-repelling and bacteria-killing mechanisms, have been developed, none of them have been entirely successful due to their inherent drawbacks. In recent years, antibacterial coatings that are responsive to the bacterial microenvironment, that possess two or more killing mechanisms, or that have triggered-cleaning capability have emerged as promising solutions for bacterial infection and contamination problems...
January 4, 2019: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30609243/functionalization-of-plla-with-polymer-brushes-to-trigger-the-assembly-of-fibronectin-into-nanonetworks
#20
Mark Robert Sprott, Gloria Gallego-Ferrer, Matthew J Dalby, Manuel Salmerón-Sánchez, Marco Cantini
Poly-l-lactic acid (PLLA) has been used as a biodegradable polymer for many years; the key characteristics of this polymer make it a versatile and useful resource for regenerative medicine. However, it is not inherently bioactive. Thus, here, a novel process is presented to functionalize PLLA surfaces with poly(ethyl acrylate) (PEA) brushes to provide biological functionality through PEA's ability to induce spontaneous organization of the extracellular matrix component fibronectin (FN) into physiological-like nanofibrils...
January 4, 2019: Advanced Healthcare Materials
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