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Advanced Healthcare Materials

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https://www.readbyqxmd.com/read/29045017/connecting-biology-to-electronics-molecular-communication-via-redox-modality
#1
REVIEW
Yi Liu, Jinyang Li, Tanya Tschirhart, Jessica L Terrell, Eunkyoung Kim, Chen-Yu Tsao, Deanna L Kelly, William E Bentley, Gregory F Payne
Biology and electronics are both expert at for accessing, analyzing, and responding to information. Biology uses ions, small molecules, and macromolecules to receive, analyze, store, and transmit information, whereas electronic devices receive input in the form of electromagnetic radiation, process the information using electrons, and then transmit output as electromagnetic waves. Generating the capabilities to connect biology-electronic modalities offers exciting opportunities to shape the future of biosensors, point-of-care medicine, and wearable/implantable devices...
October 18, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29034608/nanoparticle-based-therapeutics-for-brain-injury
#2
REVIEW
Vimala N Bharadwaj, Duong T Nguyen, Vikram D Kodibagkar, Sarah E Stabenfeldt
Brain injuries affect a large patient population with major physical and emotional suffering for patients and their relatives; at a significant cost to the society. Effective diagnostic and therapeutic options available for brain injuries are limited by the complex brain injury pathology involving blood-brain barrier (BBB). Brain injuries, including ischemic stroke and brain trauma, initiate BBB opening for a short period of time, which is followed by a second reopening for an extended time. The leaky BBB and/or the alterations in the receptor expression on BBB may provide opportunities for therapeutic delivery via nanoparticles (NPs)...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29034591/organ-on-a-chip-platforms-a-convergence-of-advanced-materials-cells-and-microscale-technologies
#3
REVIEW
Samad Ahadian, Robert Civitarese, Dawn Bannerman, Mohammad Hossein Mohammadi, Rick Lu, Erika Wang, Locke Davenport-Huyer, Ben Lai, Boyang Zhang, Yimu Zhao, Serena Mandla, Anastasia Korolj, Milica Radisic
Significant advances in biomaterials, stem cell biology, and microscale technologies have enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs, referred to as organ-on-a-chip (OOC) platforms, have emerged as a powerful tool in tissue analysis and disease modeling for biological and pharmacological applications. A variety of biomaterials are used in tissue fabrication providing multiple biological, structural, and mechanical cues in the regulation of cell behavior and tissue morphogenesis...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29034587/open-fluidics-a-cell-culture-flow-system-developed-over-wettability-contrast-based-chips
#4
Nuno M Oliveira, Rui L Reis, João F Mano
Biological tissues are recurrently exposed to several dynamic mechanical forces that influence cell behavior. On this work, the focus is on the shear stress forces induced by fluid flow. The study of flow-induced effects on cells leads to important advances in cardiovascular, cancer, stem cell, and bone biology understanding. These studies are performed using cell culture flow (CCF) systems, mainly parallel plate flow chambers (PPFC), and microfluidic systems. Here, it is proposed an original CCF system based on the open fluidics concept...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29034584/modern-therapeutic-approaches-for-noninfectious-ocular-diseases-involving-inflammation
#5
REVIEW
Michelle L Ratay, Elena Bellotti, Riccardo Gottardi, Steven R Little
Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29024556/synthesis-of-metal-nanoparticles-in-metal-phenolic-networks-catalytic-and-antimicrobial-applications-of-coated-textiles
#6
Gyeongwon Yun, Shuaijun Pan, Ting-Yi Wang, Junling Guo, Joseph J Richardson, Frank Caruso
The synthesis of metal nanoparticle (NP)-coated textiles (nanotextiles) is achieved by a dipping process in water without toxic chemicals or complicated synthetic procedures. By taking advantage of the unique nature of tannic acid, metal-phenolic network-coated textiles serve as reducing and stabilizing sites for the generation of metal nanoparticles of controllable size. The textiles can be decorated with various metal nanoparticles, including palladium, silver, or gold, and exhibit properties derived from the presence of the metal nanoparticles, for example, catalytic activity in water (>96% over five cycles using palladium nanoparticles) and antibacterial activity against Gram-negative bacteria (inhibition of Escherichia coli using silver nanoparticles) that outperforms a commercial bandage...
October 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29024487/controlling-the-release-of-small-bioactive-proteins-via-dual-mechanisms-with-therapeutic-potential
#7
Prathamesh M Kharkar, Rebecca A Scott, Laura P Olney, Paige J LeValley, Emanual Maverakis, Kristi L Kiick, April M Kloxin
Injectable delivery systems that respond to biologically relevant stimuli present an attractive strategy for tailorable drug release. Here, the design and synthesis of unique polymers are reported for the creation of hydrogels that are formed in situ and degrade in response to clinically relevant endogenous and exogenous stimuli, specifically reducing microenvironments and externally applied light. Hydrogels are formed with polyethylene glycol and heparin-based polymers using a Michael-type addition reaction...
October 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28994225/scaffold-composition-determines-the-angiogenic-outcome-of-cell-based-vascular-endothelial-growth-factor-expression-by-modulating-its-microenvironmental-distribution
#8
Emanuele Gaudiello, Ludovic Melly, Giulia Cerino, Stefano Boccardo, Sasan Jalili-Firoozinezhad, Lifen Xu, Friedrich Eckstein, Ivan Martin, Beat A Kaufmann, Andrea Banfi, Anna Marsano
Delivery of genetically modified cells overexpressing Vascular Endothelial Growth Factor (VEGF) is a promising approach to induce therapeutic angiogenesis in ischemic tissues. The effect of the protein is strictly modulated by its interaction with the components of the extracellular matrix. Its therapeutic potential depends on a sustained but controlled release at the microenvironmental level in order to avoid the formation of abnormal blood vessels. In this study, it is hypothesized that the composition of the scaffold plays a key role in modulating the binding, hence the therapeutic effect, of the VEGF released by 3D-cell constructs...
October 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28990364/synthesis-functionalization-and-design-of-magnetic-nanoparticles-for-theranostic-applications
#9
REVIEW
Jalal Mosayebi, Mehdi Kiyasatfar, Sophie Laurent
In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non-invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section...
October 9, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28985032/organ-on-a-chip-systems-for-women-s-health-applications
#10
REVIEW
Janna Nawroth, Julia Rogal, Martin Weiss, Sara Y Brucker, Peter Loskill
Biomedical research, for a long time, has paid little attention to the influence of sex in many areas of study, ranging from molecular and cellular biology to animal models and clinical studies on human subjects. Many studies solely rely on male cells/tissues/animals/humans, although there are profound differences in male and female physiology, which can significantly impact disease mechanisms, toxicity of compounds, and efficacy of pharmaceuticals. In vitro systems have been traditionally very limited in their capacity to recapitulate female-specific physiology and anatomy such as dynamic sex-hormone levels and the complex interdependencies of female reproductive tract organs...
October 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28975768/a-physicochemically-optimized-and-neuroconductive-biphasic-nerve-guidance-conduit-for-peripheral-nerve-repair
#11
Alan J Ryan, William A Lackington, Alan J Hibbitts, Austyn Matheson, Tijna Alekseeva, Anna Stejskalova, Phoebe Roche, Fergal J O'Brien
Clinically available hollow nerve guidance conduits (NGCs) have had limited success in treating large peripheral nerve injuries. This study aims to develop a biphasic NGC combining a physicochemically optimized collagen outer conduit to bridge the transected nerve, and a neuroconductive hyaluronic acid-based luminal filler to support regeneration. The outer conduit is mechanically optimized by manipulating crosslinking and collagen density, allowing the engineering of a high wall permeability to mitigate the risk of neuroma formation, while also maintaining physiologically relevant stiffness and enzymatic degradation tuned to coincide with regeneration rates...
October 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28975716/programmable-hydrogels-for-cell-encapsulation-and-neo-tissue-growth-to-enable-personalized-tissue-engineering
#12
REVIEW
Stephanie J Bryant, Franck J Vernerey
Biomimetic and biodegradable synthetic hydrogels are emerging as a promising platform for cell encapsulation and tissue engineering. Notably, synthetic-based hydrogels offer highly programmable macroscopic properties (e.g., mechanical, swelling and transport properties) and degradation profiles through control over several tunable parameters (e.g., the initial network structure, degradation kinetics and behavior, and polymer properties). One component to success is the ability to maintain structural integrity as the hydrogel transitions to neo-tissue...
October 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28961393/development-of-antifouling-and-bactericidal-coatings-for-platelet-storage-bags-using-dopamine-chemistry
#13
Narges Hadjesfandiari, Marie Weinhart, Jayachandran N Kizhakkedathu, Rainer Haag, Donald E Brooks
Platelets have a limited shelf life, due to the risk of bacterial contamination and platelet quality loss. Most platelet storage bags are made of a mixture of polyvinyl chloride with a plasticizer, denoted as pPVC. To improve biocompatibility of pPVC with platelets and to inhibit bacterial biofilm formation, an antifouling polymer coating is developed using mussel-inspired chemistry. A copolymer of N,N-dimethylacrylamide and N-(3-aminopropyl)methacrylamide hydrochloride is synthesized and coupled with catechol groups, named DA51-cat...
September 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28961385/droplet-microarray-based-on-patterned-superhydrophobic-surfaces-prevents-stem-cell-differentiation-and-enables-high-throughput-stem-cell-screening
#14
Tina Tronser, Anna A Popova, Mona Jaggy, Martin Bastmeyer, Pavel A Levkin
Over the past decades, stem cells have attracted growing interest in fundamental biological and biomedical research as well as in regenerative medicine, due to their unique ability to self-renew and differentiate into various cell types. Long-term maintenance of the self-renewal ability and inhibition of spontaneous differentiation, however, still remain challenging and are not fully understood. Uncontrolled spontaneous differentiation of stem cells makes high-throughput screening of stem cells also difficult...
September 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28961378/recent-advances-in-the-generation-of-antibody-nanomaterial-conjugates
#15
REVIEW
Amal J Sivaram, Andri Wardiana, Christopher B Howard, Stephen M Mahler, Kristofer J Thurecht
Targeted nanomedicines have significantly changed the way new therapeutics are designed to treat disease. Central to successful therapeutics is the ability to control the dynamics of protein-nanomaterial interactions to enhance the therapeutic effect of the nanomedicine. The aim of this review is to illustrate the diversity and versatility of the conjugation approaches involved in the synthesis of antibody-nanoparticle conjugates, and highlight significant new advances in the field of bioconjugation. Such nanomedicines have found utility as both advanced therapeutic agents, as well as more complex imaging contrast agents that can provide both anatomical and functional information of diseased tissue...
September 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28961377/droplet-templated-antisolvent-spherical-crystallization-of-hydrophilic-and-hydrophobic-drugs-with-an-in-situ-formed-binder
#16
Tonghan Gu, Eunice W Q Yeap, Zheng Cao, Denise Z L Ng, Yinying Ren, Ran Chen, Saif A Khan, T Alan Hatton
This study presents a novel droplet-templated antisolvent spherical crystallization method applicable to both hydrophilic and hydrophobic drugs. In both cases, an alginate hydrogel binder forms in situ, concurrently with the crystallization process, effectively binding the drug crystals into monodisperse spheres. This study presents a detailed process description with mass transfer modeling, and with characterization of the obtained alginate/drug spheres in terms of morphology, composition, and drug loading...
September 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28960916/preservation-of-cell-structure-metabolism-and-biotransformation-activity-of-liver-on-chip-organ-models-by-hypothermic-storage
#17
Marko Gröger, Julia Dinger, Michael Kiehntopf, Frank T Peters, Ursula Rauen, Alexander S Mosig
The liver is a central organ in the metabolization of nutrition, endogenous and exogenous substances, and xenobiotic drugs. The emerging organ-on-chip technology has paved the way to model essential liver functions as well as certain aspects of liver disease in vitro in liver-on-chip models. However, a broader use of this technology in biomedical research is limited by a lack of protocols that enable the short-term preservation of preassembled liver-on-chip models for stocking or delivery to researchers outside the bioengineering community...
September 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28960892/strategies-for-optimizing-the-soft-tissue-seal-around-osseointegrated-implants
#18
REVIEW
Mohamed-Nur Abdallah, Zahi Badran, Ovidiu Ciobanu, Nader Hamdan, Faleh Tamimi
Percutaneous and permucosal devices such as catheters, infusion pumps, orthopedic, and dental implants are commonly used in medical treatments. However, these useful devices breach the soft tissue barrier that protects the body from the outer environment, and thus increase bacterial infections resulting in morbidity and mortality. Such associated infections can be prevented if these devices are effectively integrated with the surrounding soft tissue, and thus creating a strong seal from the surrounding environment...
September 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28945945/macromolecular-antiviral-agents-against-zika-ebola-sars-and-other-pathogenic-viruses
#19
Franziska Schandock, Camilla Frich Riber, Annika Röcker, Janis A Müller, Mirja Harms, Paulina Gajda, Kaja Zuwala, Anna H F Andersen, Kaja Borup Løvschall, Martin Tolstrup, Florian Kreppel, Jan Münch, Alexander N Zelikin
Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28945015/membrane-fusion-mediated-intracellular-delivery-of-lipid-bilayer-coated-mesoporous-silica-nanoparticles
#20
Jian Yang, Jing Tu, Gerda E M Lamers, René C L Olsthoorn, Alexander Kros
Protein delivery into the cytosol of cells is a challenging topic in the field of nanomedicine, because cellular uptake and endosomal escape are typically inefficient, hampering clinical applications. In this contribution cuboidal mesoporous silica nanoparticles (MSNs) containing disk-shaped cavities with a large pore diameter (10 nm) are studied as a protein delivery vehicle using cytochrome-c (cytC) as a model membrane-impermeable protein. To ensure colloidal stability, the MSNs are coated with a fusogenic lipid bilayer (LB) and cellular uptake is induced by a complementary pair of coiled-coil (CC) lipopeptides...
September 25, 2017: Advanced Healthcare Materials
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