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Advanced Healthcare Materials

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https://www.readbyqxmd.com/read/28547895/review-of-flexible-temperature-sensing-networks-for-wearable-physiological-monitoring
#1
REVIEW
Qiao Li, Li-Na Zhang, Xiao-Ming Tao, Xin Ding
Physiological temperature varies temporally and spatially. Accurate and real-time detection of localized temperature changes in biological tissues regardless of large deformation is crucial to understand thermal principle of homeostasis, to assess sophisticated health conditions, and further to offer possibilities of building a smart healthcare and medical system. Additionally, continuous temperature mapping in flexible and stretchable formats opens up many other potential areas, such as artificially electronic skins and reflection of emotional changes...
May 26, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28544655/3d-bioprinting-human-induced-pluripotent-stem-cell-constructs-for-in-situ-cell-proliferation-and-successive-multilineage-differentiation
#2
Qi Gu, Eva Tomaskovic-Crook, Gordon G Wallace, Jeremy M Crook
The ability to create 3D tissues from induced pluripotent stem cells (iPSCs) is poised to revolutionize stem cell research and regenerative medicine, including individualized, patient-specific stem cell-based treatments. There are, however, few examples of tissue engineering using iPSCs. Their culture and differentiation is predominantly planar for monolayer cell support or induction of self-organizing embryoids (EBs) and organoids. Bioprinting iPSCs with advanced biomaterials promises to augment efforts to develop 3D tissues, ideally comprising direct-write printing of cells for encapsulation, proliferation, and differentiation...
May 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28544639/biomimetic-model-of-tumor-microenvironment-on-microfluidic-platform
#3
Minhwan Chung, Jungho Ahn, Kyungmin Son, Sudong Kim, Noo Li Jeon
The "Tumor microenvironment" (TME) is a complex, interacting system of the tumor and its surrounding environment. The TME has drawn more attention recently in attempts to overcome current drug resistance and the recurrence of cancer by understanding the cancer and its microenvironment systematically, beyond past reductionist approaches. However, a lack of experimental tools to dissect the intricate interactions has hampered in-depth research into the TME. Here, a biomimetic TME model using a microfluidic platform is presented, which enables the interaction between TME constituents to be studied in a comprehensive manner...
May 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28544743/deconvoluting-the-bioactivity-of-calcium-phosphate-based-bone-graft-substitutes-strategies-to-understand-the-role-of-individual-material-properties
#4
REVIEW
Víctor Pablo Galván-Chacón, Pamela Habibovic
Calcium phosphate (CaP)-based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physico-chemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial-and-error approach to a design-driven approach in the development of new functional biomaterials...
May 23, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28544647/dual-cross-linked-biofunctional-and-self-healing-networks-to-generate-user-defined-modular-gradient-hydrogel-constructs
#5
Zhao Wei, Daniel M Lewis, Yu Xu, Sharon Gerecht
Gradient hydrogels have been developed to mimic the spatiotemporal differences of multiple gradient cues in tissues. Current approaches used to generate such hydrogels are restricted to a single gradient shape and distribution. Here, a hydrogel is designed that includes two chemical cross-linking networks, biofunctional, and self-healing networks, enabling the customizable formation of modular gradient hydrogel construct with various gradient distributions and flexible shapes. The biofunctional networks are formed via Michael addition between the acrylates of oxidized acrylated hyaluronic acid (OAHA) and the dithiol of matrix metalloproteinase (MMP)-sensitive cross-linker and RGD peptides...
May 23, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28524375/bioprinted-osteogenic-and-vasculogenic-patterns-for-engineering-3d-bone-tissue
#6
Batzaya Byambaa, Nasim Annabi, Kan Yue, Grissel Trujillo-de Santiago, Mario Moisés Alvarez, Weitao Jia, Mehdi Kazemzadeh-Narbat, Su Ryon Shin, Ali Tamayol, Ali Khademhosseini
Fabricating 3D large-scale bone tissue constructs with functional vasculature has been a particular challenge in engineering tissues suitable for repairing large bone defects. To address this challenge, an extrusion-based direct-writing bioprinting strategy is utilized to fabricate microstructured bone-like tissue constructs containing a perfusable vascular lumen. The bioprinted constructs are used as biomimetic in vitro matrices to co-culture human umbilical vein endothelial cells and bone marrow derived human mesenchymal stem cells in a naturally derived hydrogel...
May 19, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28516460/taxane-grafted-metal-oxide-nanoparticles-as-a-new-theranostic-tool-against-cancer-the-promising-example-of-docetaxel-functionalized-titanate-nanotubes-on-prostate-tumors
#7
Alexis Loiseau, Julien Boudon, Céline Mirjolet, Gilles Créhange, Nadine Millot
The combination of anticancer drugs and metal oxide nanoparticles is of great interest in cancer nanomedicine. Here, the development of a new nanohybrid, titanate nanotube-docetaxel (TiONts-DTX) is reported, the two parts of which are conjugated by covalent linkages. Unlike most nanoparticles currently being developed for biomedical purposes, TiONts present a needle-shaped morphology. The surface of TiONts is linked with 3-aminopropyl triethoxysilane and with a hetero-bifunctional polymer (polyethylene glycol) to create well-dispersed and biocompatible nanovectors...
May 18, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28512791/peptide-functionalized-fluorescent-particles-for-in-situ-detection-of-nitric-oxide-via-peroxynitrite-mediated-nitration
#8
Jason Y H Chang, Lesley W Chow, W Michael Dismuke, C Ross Ethier, Molly M Stevens, W Daniel Stamer, Darryl R Overby
Nitric oxide (NO) is a free radical signaling molecule that plays a crucial role in modulating physiological homeostasis across multiple biological systems. NO dysregulation is linked to the pathogenesis of multiple diseases; therefore, its quantification is important for understanding pathophysiological processes. The detection of NO is challenging, typically limited by its reactive nature and short half-life. Additionally, the presence of interfering analytes and accessibility to biological fluids in the native tissues make the measurement technically challenging and often unreliable...
May 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28509442/self-assembled-nanoparticles-from-phenolic-derivatives-for-cancer-therapy
#9
Yunlu Dai, Junling Guo, Ting-Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt, Frank Caruso
Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Herein, a facile and rapid method is introduced to assemble poly(ethylene glycol) (PEG)-modified Pt prodrug nanocomplexes through metal-polyphenol complexation and combined with emulsification, which results in ≈100 nm diameter nanoparticles (PtP NPs) that exhibit high drug loading (0.15 fg Pt per nanoparticle) and low fouling properties. The PtP NPs are characterized for potential use as cancer therapeutics...
May 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28509437/detection-of-avian-influenza-virus-from-cloacal-swabs-using-a-disposable-well-gate-fet-sensor
#10
Sungwook Park, Jaebin Choi, Minhong Jeun, Yongdeok Kim, Seong-Su Yuk, Sang Kyung Kim, Chang-Seon Song, Seok Lee, Kwan Hyi Lee
Current methods to detect avian influenza viruses (AIV) are time consuming and lo inw sensitivity, necessitating a faster and more sensitive sensor for on-site epidemic detection in poultry farms and urban population centers. This study reports a field effect transistor (FET) based AIV sensor that detects nucleoproteins (NP) within 30 minutes, down to an LOD of 10(3) EID50 mL(-1) from a live animal cloacal swab. Previously reported FET sensors for AIV detection have not targeted NPs, an internal protein shared across multiple strains, due to the difficulty of field-effect sensing in a highly ionic lysis buffer...
May 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28509413/microcarriers-with-synthetic-hydrogel-surfaces-for-stem-cell-expansion
#11
Andrew D Dias, Jonathan M Elicson, William L Murphy
Microcarriers are scalable support surfaces for cell growth that enable high levels of expansion, and are particularly relevant for expansion of human mesenchymal stem cells (hMSCs). The goal of this study is to develop a poly(ethylene glycol) (PEG)-based microcarrier coating for hMSC expansion. Commercially available microcarriers do not offer customizability of microcarrier surface properties, including elastic modulus and surface cell adhesion ligands. The lab has previously demonstrated that tuning these material properties on PEG-based hydrogels can modulate important cellular growth characteristics, such as cell attachment and expansion, which are important in microcarrier-based culture...
May 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28509381/topography-guided-control-of-local-migratory-behaviors-and-protein-expression-of-cancer-cells
#12
Jung-Youn Shin, Hong Nam Kim, Suk Ho Bhang, Jeong-Kee Yoon, Kahp-Yang Suh, Noo Li Jeon, Byung-Soo Kim
In vivo cancer cell migration and invasion are directed by biophysical guidance mechanisms such as pre-existing microtracks and basement membrane extracellular matrices. Here, this paper reports the correlation of the local migratory behavior of cancer cells and the biochemical signal expression using the topography that can guide or inhibit cell behaviors. To this end, the local apparent migration and the protein expression level are investigated with respect to the topographical feature size (flat, nanoline, and microline) and orientation (microline, microconcentric, and microradial) with the collectively migrating (A431) and individually migrating (MDA-MB-231 and U-87-MG) cancer cells...
May 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28504415/highly-luminescent-folate-functionalized-au22-nanoclusters-for-bioimaging
#13
Kyunglim Pyo, Nguyen Hoang Ly, Sook Young Yoon, Yiming Shen, Seon Young Choi, So Yeong Lee, Sang-Woo Joo, Dongil Lee
Gold nanoclusters are emerging as new materials for biomedical applications because of promises offered by their ultrasmall size and excellent biocompatibility. Here, the synthesis and optical and biological characterizations of a highly luminescent folate-functionalized Au22 cluster (Au22 -FA) are reported. The Au22 -FA clusters are synthesized by functionalizing the surface of Au22 (SG)18 clusters, where SG is glutathione, with benzyl chloroformate and folate. The functionalized clusters are highly water-soluble and exhibit remarkably bright luminescence with a quantum yield of 42%, significantly higher than any other water-soluble gold clusters protected with thiolate ligands...
May 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28504409/multifunctional-liposomes-for-image-guided-intratumoral-chemo-phototherapy
#14
Dyego Miranda, Kevin Carter, Dandan Luo, Shuai Shao, Jumin Geng, Changning Li, Upendra Chitgupi, Steven G Turowski, Nasi Li, G Ekin Atilla-Gokcumen, Joseph A Spernyak, Jonathan F Lovell
Intratumoral (IT) drug injections reduce systemic toxicity, but delivered volumes and distribution can be inconsistent. To improve IT delivery paradigms, porphyrin-phospholipid (PoP) liposomes are passively loaded with three hydrophilic cargos: sulforhodamine B, a fluorophore; gadolinium-gadopentetic acid, a magnetic resonance (MR) agent; and oxaliplatin, a colorectal cancer chemotherapeutic. Liposome composition is optimized so that cargo is retained in serum and storage, but is released in less than 1 min with exposure to near infrared light...
May 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28504348/broad-spectrum-macromolecular-antimicrobials-with-biofilm-disruption-capability-and-in-vivo-efficacy
#15
Jeremy P K Tan, Daniel J Coady, Haritz Sardon, Alexander Yuen, Shujun Gao, Shaun W Lim, Zhen Chang Liang, Eddy W Tan, Shrinivas Venkataraman, Amanda C Engler, Mareva Fevre, Robert Ono, Yi Yan Yang, James L Hedrick
In this study, antimicrobial polymers are synthesized by the organocatalytic ring-opening polymerization of an eight-membered heterocyclic carbonate monomer that is subsequently quaternized with methyl iodide. These polymers demonstrate activity against clinically relevant Gram-positive Staphylococcus epidermidis and Staphylococcus aureus, Gram-negative Escherichia coli and Pseudomonas aeruginosa, and fungus Candida albicans with fast killing kinetics. Importantly, the polymer efficiently inhibits biofilm growth and lyses existing biofilm, leading to a reduction in biomass and cell viability...
May 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28498548/engineered-3d-cardiac-fibrotic-tissue-to-study-fibrotic-remodeling
#16
Amir Hossein Sadeghi, Su Ryon Shin, Janine C Deddens, Giuseppe Fratta, Serena Mandla, Iman K Yazdi, Gyan Prakash, Silvia Antona, Danilo Demarchi, Marc P Buijsrogge, Joost P G Sluijter, Jesper Hjortnaes, Ali Khademhosseini
Activation of cardiac fibroblasts into myofibroblasts is considered to play an essential role in cardiac remodeling and fibrosis. A limiting factor in studying this process is the spontaneous activation of cardiac fibroblasts when cultured on two-dimensional (2D) culture plates. In this study, a simplified three-dimensional (3D) hydrogel platform of contractile cardiac tissue, stimulated by transforming growth factor-β1 (TGF-β1), is presented to recapitulate a fibrogenic microenvironment. It is hypothesized that the quiescent state of cardiac fibroblasts can be maintained by mimicking the mechanical stiffness of native heart tissue...
May 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28493521/a-freeze-concentration-and-polyampholyte-modified-liposome-based-antigen-delivery-system-for-effective-immunotherapy
#17
Sana Ahmed, Satoshi Fujita, Kazuaki Matsumura
Immunotherapy is an exciting new approach to cancer treatment. The development of a novel freeze-concentration method is described that could be applicable in immunotherapy. The method involves freezing cells in the presence of pH-sensitive, polyampholyte-modified liposomes with encapsulated ovalbumin (OVA) as the antigen. In RAW 264.7 cells, compared to unfrozen, freeze-concentration of polyampholyte-modified liposomes encapsulating OVA resulted in efficient OVA uptake and also allowed its delivery to the cytosol...
May 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28493386/a-ferroelectric-ceramic-polymer-composite-based-capacitive-electrode-array-for-in-vivo-recordings
#18
Changyong Chen, Miaomiao Xue, Yige Wen, Guang Yao, Yan Cui, Feiyi Liao, Zhuocheng Yan, Long Huang, Saeed Ahmed Khan, Min Gao, Taisong Pan, Hulin Zhang, Wei Jing, Daqing Guo, Sanfeng Zhang, Hailiang Yao, Xiong Zhou, Qiang Li, Yang Xia, Yuan Lin
A new implantable capacitive electrode array for electrocorticography signal recording is developed with ferroelectric ceramic/polymer composite. This ultrathin and electrically safe capacitive electrode array is capable of attaching to the biological tissue conformably. The barium titanate/polyimide (BaTiO3 /PI) nanocomposite with high dielectric constant is successfully synthesized and employed as the ultrathin dielectric layer of the capacitive BaTiO3 /PI electrode array. The performance of the capacitive BaTiO3 /PI electrode array is evaluated by electrical characterization and 3D finite-element modeling...
May 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28489332/damage-healing-and-remodeling-in-optogenetic-skeletal-muscle-bioactuators
#19
Ritu Raman, Lauren Grant, Yongbeom Seo, Caroline Cvetkovic, Michael Gapinske, Alexandra Palasz, Howard Dabbous, Hyunjoon Kong, Pablo Perez Pinera, Rashid Bashir
A deeper understanding of biological materials and the design principles that govern them, combined with the enabling technology of 3D printing, has given rise to the idea of "building with biology." Using these materials and tools, bio-hybrid robots or bio-bots, which adaptively sense and respond to their environment, can be manufactured. Skeletal muscle bioactuators are developed to power these bio-bots, and an approach is presented to make them dynamically responsive to changing environmental loads and robustly resilient to induced damage...
May 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28489328/induction-of-chondrogenic-differentiation-of-human-mesenchymal-stem-cells-by-biomimetic-gold-nanoparticles-with-tunable-rgd-density
#20
Jingchao Li, Xiaomeng Li, Jing Zhang, Naoki Kawazoe, Guoping Chen
Nanostructured materials have drawn a broad attention for their applications in biomedical fields. Ligand-modified nanomaterials can well mimic the dynamic extracellular matrix (ECM) microenvironments to regulate cell functions and fates. Herein, ECM mimetic gold nanoparticles (Au NPs) with tunable surface arginine-glycine-aspartate (RGD) density are designed and synthesized to induce the chondrogenic differentiation of human mesenchymal stem cells (hMSCs). The biomimetic Au NPs with an average size of 40 nm shows good biocompatibility without affecting the cell proliferation in the studied concentration range...
May 10, 2017: Advanced Healthcare Materials
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