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Advanced Healthcare Materials

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https://www.readbyqxmd.com/read/28809092/particle-targeting-in-complex-biological-media
#1
REVIEW
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Björnmalm, Christina Cortez-Jugo, Frank Caruso
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with specific cells and tissues, and accumulate at desired target sites, reducing side effects and improve overall efficacy in applications such as vaccination and drug delivery. However, when targeted particles enter a complex biological environment, the adsorption of biomolecules and the formation of a surface coating (e...
August 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28805046/electroenhanced-antimicrobial-coating-based-on-conjugated-polymers-with-covalently-coupled-silver-nanoparticles-prevents-staphylococcus-aureus-biofilm-formation
#2
Salvador Gomez-Carretero, Rolf Nybom, Agneta Richter-Dahlfors
The incidence of hospital-acquired infections is to a large extent due to device-associated infections. Bacterial attachment and biofilm formation on surfaces of medical devices often act as seeding points of infection. To prevent such infections, coatings based on silver nanoparticles (AgNPs) are often applied, however with varying clinical success. Here, the traditional AgNP-based antibacterial technology is reimagined, now forming the base for an electroenhanced antimicrobial coating. To integrate AgNPs in an electrically conducting polymer layer, a simple, yet effective chemical strategy based on poly(hydroxymethyl 3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT-MeOH:PSS) and (3-aminopropyl)triethoxysilane is designed...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28804984/3d-bioprinting-for-cartilage-and-osteochondral-tissue-engineering
#3
REVIEW
Andrew C Daly, Fiona E Freeman, Tomas Gonzalez-Fernandez, Susan E Critchley, Jessica Nulty, Daniel J Kelly
Significant progress has been made in the field of cartilage and bone tissue engineering over the last two decades. As a result, there is real promise that strategies to regenerate rather than replace damaged or diseased bones and joints will one day reach the clinic however, a number of major challenges must still be addressed before this becomes a reality. These include vascularization in the context of large bone defect repair, engineering complex gradients for bone-soft tissue interface regeneration and recapitulating the stratified zonal architecture present in many adult tissues such as articular cartilage...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28795534/graphene-field-effect-transistors-for-the-sensitive-and-selective-detection-of-escherichia-coli-using-pyrene-tagged-dna-aptamer
#4
Guangfu Wu, Ziwen Dai, Xin Tang, Zihong Lin, Pik Kwan Lo, Meyya Meyyappan, King Wai Chiu Lai
This study reports biosensing using graphene field-effect transistors with the aid of pyrene-tagged DNA aptamers, which exhibit excellent selectivity, affinity, and stability for Escherichia coli (E. coli) detection. The aptamer is employed as the sensing probe due to its advantages such as high stability and high affinity toward small molecules and even whole cells. The change of the carrier density in the probe-modified graphene due to the attachment of E. coli is discussed theoretically for the first time and also verified experimentally...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28795530/construction-of-silica-based-micro-nanoplatforms-for-ultrasound-theranostic-biomedicine
#5
REVIEW
Yang Zhou, Xiaoxia Han, Xiangxiang Jing, Yu Chen
Ultrasound (US)-based biomedicine has been extensively explored for its applications in both diagnostic imaging and disease therapy. The fast development of theranostic nanomedicine significantly promotes the development of US-based biomedicine. This progress report summarizes and discusses the recent developments of rational design and fabrication of silica-based micro/nanoparticles for versatile US-based biomedical applications. The synthetic strategies and surface-engineering approaches of silica-based micro/nanoparticles are initially discussed, followed by detailed introduction on their US-based theranostic applications...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28795516/the-potential-of-liquid-marbles-for-biomedical-applications-a-critical-review
#6
REVIEW
Nuno M Oliveira, Rui L Reis, João F Mano
Liquid marbles (LM) are freestanding droplets covered by micro/nanoparticles with hydrophobic/hydrophilic properties, which can be manipulated as a soft solid. The phenomenon that generates these soft structures is regarded as a different method to generate a superhydrophobic behavior in the liquid/solid interface without modifying the surface. Several applications for the LM have been reported in very different fields, however the developments for biomedical applications are very recent. At first, the LM properties are reviewed, namely shell structure, LM shape, evaporation, floatability and robustness...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28795515/multiplexed-optogenetic-stimulation-of-neurons-with-spectrum-selective-upconversion-nanoparticles
#7
Xudong Lin, Ying Wang, Xian Chen, Runhuai Yang, Zixun Wang, Jingyu Feng, Haitao Wang, King W C Lai, Jufang He, Feng Wang, Peng Shi
Optical modulation of nervous system becomes increasingly popular as the wide adoption of optogenetics. For these applications, upconversion materials hold great promise as novel photonic elements. This study describes an upconversion based strategy for combinatorial neural stimulation both in vitro and in vivo by using spectrum-selective upconversion nanoparticles (UCNPs). NaYF4 based UCNPs are used to absorb near-infrared (NIR) energy and to emit visible light for stimulating neurons expressing different channelrhodopsin (ChR) proteins...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28795507/bright-aie-nanoparticles-with-f127-encapsulation-for-deep-tissue-three-photon-intravital-brain-angiography
#8
Yalun Wang, Xiao Han, Wang Xi, Jinyu Li, Anna Wang Roe, Ping Lu, Jun Qian
Deep-tissue imaging is of great significance to biological applications. In this paper, a deep-red emissive luminogen 2,3-bis(4'-(diphenylamino)-[1,1'-biphenyl]-4-yl) fumaronitrile (TPATCN) with aggregation-induced emission (AIE) feature is prepared. TPATCN molecules were then encapsulated within a polymeric matrix of Pluronic F-127 to form nanoparticles (NPs). TPATCN NPs exhibit bright three-photon fluorescence (3PF) in deep-red region, together with high chemical stability, good photostability, and biocompatibility...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28795496/silicone-based-adhesives-with-highly-tunable-adhesion-force-for-skin-contact-applications
#9
Bong Kuk Lee, Jin Hwa Ryu, In-Bok Baek, Yarkyeon Kim, Won Ick Jang, Sang-Hyeob Kim, Yong Sun Yoon, Seung Hwan Kim, Seong-Gu Hong, Sangwon Byun, Han Young Yu
A fundamental approach to fabricating silicone-based adhesives with highly tunable adhesion force for the skin-contact applications is presented. Liquid blends consisting of vinyl-multifunctional polydimethylsiloxane (V-PDMS), hydride-terminated PDMS (H-PDMS), and a tackifier composed of a silanol-terminated PDMS/MQ resin mixture and the MQ resin are used as the adhesive materials. The peel adhesion force of addition-cured adhesives on the skin is increased by increasing the H-PDMS molecular weights and the tackifier content, and decreasing the H-PDMS/V-PDMS ratio...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28783879/human-perinatal-derived-biomaterials
#10
REVIEW
Marc C Moore, Aurore Van De Walle, Jerry Chang, Cassandra Juran, Peter S McFetridge
Human perinatal tissues have been used for over a century as allogeneic biomaterials. Due to their advantageous properties including angiogenecity, anti-inflammation, anti-microbial, and immune privilege, these tissues are being utilized for novel applications across wide-ranging medical disciplines. Given continued clinical success, increased adoption of perinatal tissues as a disruptive technology platform has allowed for significant penetration into the multi-billion dollar biologics market. Here, we review current progress and future applications of perinatal biomaterials, as well as associated regulatory issues...
August 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28783874/edible-electrochemistry-food-materials-based-electrochemical-sensors
#11
Jayoung Kim, Itthipon Jeerapan, Bianca Ciui, Martin C Hartel, Aida Martin, Joseph Wang
This study demonstrates the first example of completely food-based edible electrochemical sensors. The new edible composite electrodes consist of food materials and supplements serving as the edible conductor, corn, and olive oils as edible binders, vegetables as biocatalysts, and food-based packing sleeves. These edible composite electrodes are systematically characterized for their attractive electrochemical properties, such as potential window, capacitance, redox activity using various electrochemical techniques...
August 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28782184/integrin-mediated-interactions-control-macrophage-polarization-in-3d-hydrogels
#12
Byung-Hyun Cha, Su Ryon Shin, Jeroen Leijten, Yi-Chen Li, Sonali Singh, Julie C Liu, Nasim Annabi, Reza Abdi, Mehmet R Dokmeci, Nihal Engin Vrana, Amir M Ghaemmaghami, Ali Khademhosseini
Adverse immune reactions prevent clinical translation of numerous implantable devices and materials. Although inflammation is an essential part of tissue regeneration, chronic inflammation ultimately leads to implant failure. In particular, macrophage polarity steers the microenvironment toward inflammation or wound healing via the induction of M1 and M2 macrophages, respectively. Here, this paper demonstrates that macrophage polarity within biomaterials can be controlled through integrin-mediated interactions between human monocytic THP-1 cells and collagen-derived matrix...
August 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28777502/carbon-nanomaterials-in-biological-studies-and-biomedicine
#13
REVIEW
Nagappa L Teradal, Raz Jelinek
The "carbon nano-world" has made over the past few decades huge contributions in diverse scientific disciplines and technological advances. While dramatic advances have been widely publicized in using carbon nanomaterials such as fullerenes, carbon nanotubes, and graphene in materials sciences, nano-electronics, and photonics, their contributions to biology and biomedicine have been noteworthy as well. This Review focuses on the use of carbon nanotubes (CNTs), graphene, and carbon quantum dots [encompassing graphene quantum dots (GQDs) and carbon dots (C-dots)] in biologically oriented materials and applications...
August 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28777501/liposome-indocyanine-green-nanoprobes-for-optical-labeling-and-tracking-of-human-mesenchymal-stem-cells-post-transplantation-in-vivo
#14
Mariarosa Mazza, Neus Lozano, Debora Braga Vieira, Maurizio Buggio, Cay Kielty, Kostas Kostarelos
Direct labeling of human mesenchymal stem cells (hMSC) prior to transplantation provides a means to track cells after administration and it is a powerful tool for the assessment of new cell-based therapies. Biocompatible nanoprobes consisting of liposome-indocyanine green hybrid vesicles (liposome-ICG) are used to safely label hMSC. Labeled hMSC recapitulating a 3D cellular environment is transplanted as spheroids subcutaneously and intracranially in athymic nude mice. Cells emit a strong NIR signal used for tracking post-transplantation with the IVIS imaging system up to 2 weeks (subcutaneous) and 1 week (intracranial)...
August 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28766896/novel-cranial-implants-of-yttria-stabilized-zirconia-as-acoustic-windows-for-ultrasonic-brain-therapy
#15
Mario I Gutierrez, Elias H Penilla, Lorenzo Leija, Arturo Vera, Javier E Garay, Guillermo Aguilar
Therapeutic ultrasound can induce changes in tissues by means of thermal and nonthermal effects. It is proposed for treatment of some brain pathologies such as Alzheimer's, Parkinson's, Huntington's diseases, and cancer. However, cranium highly absorbs ultrasound reducing transmission efficiency. There are clinical applications of transcranial focused ultrasound and implantable ultrasound transducers proposed to address this problem. In this paper, biocompatible materials are proposed for replacing part of the cranium (cranial implants) based on low porosity polycrystalline 8 mol% yttria-stabilized-zirconia (8YSZ) ceramics as acoustic windows for brain therapy...
August 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28766870/extracellular-hyaluronic-acid-influences-the-efficacy-of-egfr-tyrosine-kinase-inhibitors-in-a-biomaterial-model-of-glioblastoma
#16
Sara Pedron, Jacob S Hanselman, Mark A Schroeder, Jann N Sarkaria, Brendan A C Harley
3D biomaterial models have potential to explore the influence of the tumor microenvironment on aberrant signaling pathways and compensatory signals using patient-derived cells. Glioblastoma (GBM) tumors are highly heterogeneous, with both cell composition and extracellular matrix biophysical factors seen as key regulators of malignant phenotype and treatment outcomes. Amplification, overexpression, and mutation of the epidermal growth factor receptor (EGFR) tyrosine kinase have been identified in 50% of GBM patients...
August 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28758712/spatiotemporally-controlled-release-of-rho-inhibiting-c3-toxin-from-a-protein-dna-hybrid-hydrogel-for-targeted-inhibition-of-osteoclast-formation-and-activity
#17
Jasmina Gačanin, Anna Kovtun, Stephan Fischer, Victoria Schwager, Johanna Quambusch, Seah Ling Kuan, Weina Liu, Felix Boldt, Chuang Li, Zhongqiang Yang, Dongsheng Liu, Yuzhou Wu, Tanja Weil, Holger Barth, Anita Ignatius
In osteoporosis, bone structure can be improved by the introduction of therapeutic molecules inhibiting bone resorption by osteoclasts. Here, biocompatible hydrogels represent an excellent option for the delivery of pharmacologically active molecules to the bone tissue because of their biodegradability, injectability, and manifold functionalization capacity. The present study reports the preparation of a multifunctional hybrid hydrogel from chemically modified human serum albumin and rationally designed DNA building blocks...
July 31, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28758358/freeze-drying-as-a-novel-biofabrication-method-for-achieving-a-controlled-microarchitecture-within-large-complex-natural-biomaterial-scaffolds
#18
Claire M Brougham, Tanya J Levingstone, Nian Shen, Gerard M Cooney, Stefan Jockenhoevel, Thomas C Flanagan, Fergal J O'Brien
The biofabrication of large natural biomaterial scaffolds into complex 3D shapes which have a controlled microarchitecture remains a major challenge. Freeze-drying (or lyophilization) is a technique used to generate scaffolds in planar 3D geometries. Here we report the development of a new biofabrication process to form a collagen-based scaffold into a large, complex geometry which has a large height to width ratio, and a controlled porous microarchitecture. This biofabrication process is validated through the successful development of a heart valve shaped scaffold, fabricated from a collagen-glycosaminoglycan co-polymer...
July 31, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28752598/supercritical-fluid-technology-an-emphasis-on-drug-delivery-and-related-biomedical-applications
#19
REVIEW
Ranjith Kumar Kankala, Yu Shrike Zhang, Shi-Bin Wang, Chia-Hung Lee, Ai-Zheng Chen
During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed...
July 28, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28752592/atomic-force-microscopy-as-a-tool-to-assess-the-specificity-of-targeted-nanoparticles-in-biological-models-of-high-complexity
#20
Carla P Gomes, Cátia D F Lopes, Michael Leitner, Andreas Ebner, Peter Hinterdorfer, Ana P Pêgo
The ability to design nanoparticle delivery systems capable of selectively target their payloads to specific cell populations is still a major caveat in nanomedicine. One of the main hurdles is the fact that each nanoparticle formulation needs to be precisely tuned to match the specificities of the target cell and route of administration. In this work, molecular recognition force spectroscopy (MRFS) is presented as a tool to evaluate the specificity of neuron-targeted trimethyl chitosan nanoparticles to neuronal cell populations in biological samples of different complexity...
July 28, 2017: Advanced Healthcare Materials
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