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Advanced Healthcare Materials

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https://www.readbyqxmd.com/read/30240165/bi-2-s-3-tween-20-nanodots-loading-pi3k-inhibitor-ly294002-for-mild-photothermal-therapy-of-lovo-cells-in-vitro-and-in-vivo
#1
Li Song, Xinghua Dong, Shuang Zhu, Chunfang Zhang, Wenyan Yin, Xiao Zhang, Xiangfeng Liu, Zhanjun Gu
Although various types of photothermal agents are developed for photothermal cancer therapy, relatively few photothermal agents exhibit high tumor inhibition rate under relatively mild conditions. Herein, a multifunctional Bi2 S3 -Tween 20 nanoplatform loaded with PI3K inhibitor LY294002 is designed as a novel photothermal agent for inhibitor and photothermal synergistic therapy of tumors under mild photothermal therapy conditions. The LY294002 of PI3K inhibitor, after being loaded by Bi2 S3 -Tween 20 nanodots, exhibits greatly increased drug utilization and reduced side effects on normal tissues...
September 21, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30240157/biomineralization-inspired-material-design-for-bone-regeneration
#2
REVIEW
Daniel de Melo Pereira, Pamela Habibovic
Synthetic substitutes of bone grafts, such as calcium phosphate-based ceramics, have shown some good clinical successes in the regeneration of large bone defects and are currently extensively used. In the past decade, the field of biomineralization has delivered important new fundamental knowledge and techniques to better understand this fascinating phenomenon. This knowledge is also applied in the field of biomaterials, with the aim of bringing the composition and structure, and hence the performance, of synthetic bone graft substitutes even closer to those of the extracellular matrix of bone...
September 21, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30240152/protein-nanotherapeutics-as-an-emerging-modality-for-cancer-therapy
#3
REVIEW
Liang Cheng, Liang Yang, Fenghua Meng, Zhiyuan Zhong
Protein drugs are a unique and versatile class of biotherapeutics that have not only high biological activity but also superb specificity. This rapidly evolving biotechnology has rendered it possible to produce various proteins in a large scale and reproducible way. Many proteins have demonstrated striking anticancer activities and have emerged as advanced alternatives to cytotoxic chemotherapeutic agents for cancer therapy. The clinical translation of anticancer proteins with intracellular targets is, nevertheless, severely hindered by their fast degradation in vivo, poor cell penetration, and inefficient intracellular transportation...
September 21, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30238637/the-biomedical-use-of-silk-past-present-future
#4
REVIEW
Chris Holland, Keiji Numata, Jelena Rnjak-Kovacina, F Philipp Seib
Humans have long appreciated silk for its lustrous appeal and remarkable physical properties, yet as the mysteries of silk are unraveled, it becomes clear that this outstanding biopolymer is more than a high-tech fiber. This progress report provides a critical but detailed insight into the biomedical use of silk. This journey begins with a historical perspective of silk and its uses, including the long-standing desire to reverse engineer silk. Selected silk structure-function relationships are then examined to appreciate past and current silk challenges...
September 20, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30230709/bioengineering-organs-for-blood-detoxification
#5
REVIEW
Cécile Legallais, Dooli Kim, Sylvia M Mihaila, Milos Mihajlovic, Marina Figliuzzi, Barbara Bonandrini, Simona Salerno, Fjodor A Yousef Yengej, Maarten B Rookmaaker, Natalia Sanchez Romero, Pilar Sainz-Arnal, Ulysse Pereira, Mattia Pasqua, Karin G F Gerritsen, Marianne C Verhaar, Andrea Remuzzi, Pedro M Baptista, Loredana De Bartolo, Rosalinde Masereeuw, Dimitrios Stamatialis
For patients with severe kidney or liver failure the best solution is currently organ transplantation. However, not all patients are eligible for transplantation and due to limited organ availability, most patients are currently treated with therapies using artificial kidney and artificial liver devices. These therapies, despite their relative success in preserving the patients' life, have important limitations since they can only replace part of the natural kidney or liver functions. As blood detoxification (and other functions) in these highly perfused organs is achieved by specialized cells, it seems relevant to review the approaches leading to bioengineered organs fulfilling most of the native organ functions...
September 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30230271/novel-in-situ-gelling-hydrogels-loaded-with-recombinant-collagen-peptide-microspheres-as-a-slow-release-system-induce-ectopic-bone-formation
#6
Shorouk Fahmy-Garcia, Didem Mumcuoglu, Laura de Miguel, Veerle Dieleman, Janneke Witte-Bouma, Bram C J van der Eerden, Marjolein van Driel, David Eglin, Jan A N Verhaar, Sebastiaan G J M Kluijtmans, Gerjo J V M van Osch, Eric Farrell
New solutions for large bone defect repair are needed. Here, in situ gelling slow release systems for bone induction are assessed. Collagen-I based Recombinant Peptide (RCP) microspheres (MSs) are produced and used as a carrier for bone morphogenetic protein 2 (BMP-2). The RCP-MSs are dispersed in three hydrogels: high mannuronate (SLM) alginate, high guluronate (SLG) alginate, and thermoresponsive hyaluronan derivative (HApN). HApN+RCP-MS forms a gel structure at 32 ºC or above, while SLM+RCP-MS and SLG+RCP-MS respond to shear stress displaying thixotropic behavior...
September 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30221829/incorporating-4d-into-bioprinting-real-time-magnetically-directed-collagen-fiber-alignment-for-generating-complex-multilayered-tissues
#7
Marcel Betsch, Catalin Cristian, Ying-Ying Lin, Andreas Blaeser, Jan Schöneberg, Michael Vogt, Eva Miriam Buhl, Horst Fischer, Daniela Filipa Duarte Campos
In vitro multilayered tissues with mimetic architectures resembling native tissues are valuable tools for application in medical research. In this study, an advanced bioprinting strategy is presented for aligning collagen fibers contained in functional bioinks. Streptavidin-coated iron nanoparticles are embedded in printable bioinks with varying concentrations of low gelling temperature agarose and type I collagen. By applying a straightforward magnetic-based mechanism in hydrogels during bioprinting, it is possible to align collagen fibers in less concentrated hydrogel blends with a maximum agarose concentration of 0...
September 17, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30221496/nanogel-tectonics-for-tissue-engineering-protein-delivery-systems-with-nanogel-chaperones
#8
REVIEW
Yoshihide Hashimoto, Sada-Atsu Mukai, Yoshihiro Sasaki, Kazunari Akiyoshi
Amphiphilic polysaccharide self-assembled (SA) nanogels are promising protein carriers owing to their chaperone-like activity that allows them to nanoencapsulate proteins within their polymer networks. The chaperoning function is an important concept that has led to breakthroughs in the development of effective protein drug delivery systems by stabilizing formulations and controlling the quality of unstable proteins. Recently, nanogel-tectonic materials that integrate SA nanogels as building blocks have been designed as new hydrogel biomaterials...
September 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30221474/in-situ-synchrotron-x-ray-diffraction-characterization-of-corrosion-products-of-a-ti-based-metallic-glass-for-implant-applications
#9
Petre Flaviu Gostin, Owen Addison, Alexander P Morrell, Yue Zhang, Angus J M C Cook, Alethea Liens, Mihai Stoica, Konstantin Ignatyev, Steven R Street, Jing Wu, Yu-Lung Chiu, Alison J Davenport
Ti-based bulk metallic glasses are under consideration for implants due to their high yield strength and biocompatibility. In this work, in situ synchrotron X-ray diffraction (XRD) is used to investigate the corrosion products formed from corrosion of Ti40 Zr10 Cu34 Pd14 Sn2 bulk metallic glass in artificial corrosion pits in physiological saline (NaCl). It is found that Pd nanoparticles form in the interior of the pits during electrochemical dissolution. At a low pit growth potential, the change in lattice parameter of the Pd nanoparticles is consistent with the formation of palladium hydride...
September 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30211482/mixed-and-matched-metallo-nanotexaphyrin-for-customizable-biomedical-imaging
#10
Joseph M Keca, Michael S Valic, Miffy H Y Cheng, Wenlei Jiang, Marta Overchuk, Juan Chen, Gang Zheng
The discovery and synthesis of multifunctional organic building blocks for nanoparticles have remained challenging. Texaphyrin macrocycles are multifunctional, all-organic compounds that possess versatile metal-chelation capabilities and unique theranostics properties for biomedical applications. Unfortunately, there are significant difficulties associated with the synthesis of texaphyrin-based subunits capable of forming nanoparticles. Herein, the detailed synthesis of a texaphyrin-phospholipid building block is reported via a key 1,2-dinitrophenyl-phospholipid intermediate, along with stable chelation of two clinically relevant metal ions into texaphyrin-lipid without compromising their self-assembly into texaphyrin nanoparticles or nanotexaphyrin...
September 13, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30175520/the-application-of-biomaterials-to-tissue-engineering-neural-retina-and-retinal-pigment-epithelium
#11
REVIEW
Nicola C Hunt, Dean Hallam, Valeria Chichagova, David H Steel, Majlinda Lako
The prevalence of degenerative retinal disease is ever increasing as life expectancy rises globally. The human retina fails to regenerate and the use of human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (hiPSCs) to engineer retinal tissue is of particular interest due to the limited availability of suitable allogeneic or autologous tissue. Retinal tissue and its development are well characterized, which have resulted in robust assays to assess the development of tissue-engineered retina...
September 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30175464/architectural-effects-of-star-shaped-structurally-nanoengineered-antimicrobial-peptide-polymers-snapps-on-their-biological-activity
#12
Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao
In this work, the effect of two key structural parameters, number of arms and arm length, of star-shaped "structurally nanoengineered antimicrobial peptide polymers" (SNAPPs) on their antimicrobial activity and biocompatibility, is investigated. A library of star-shaped SNAPPs is prepared, containing varying arm numbers and arm lengths. Antimicrobial assays are then performed to assess the capacity of the SNAPPs to disrupt the membrane, inhibit the growth, and kill pathogenic bacteria. A major finding of the study is that increasing arm number and length of SNAPPs enhanced antimicrobial activity, which can be respectively attributed to the higher local concentrations of polypeptide arms and increased α-helical content...
September 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30160820/blue-te-nanoneedles-with-strong-nir-photothermal-and-laser-enhanced-anticancer-effects-as-all-in-one-nanoagents-for-synergistic-thermo-chemotherapy-of-tumors
#13
Nuo Yu, Jinning Li, Zhaojie Wang, Shuyan Yang, Zixiao Liu, Yanshu Wang, Meifang Zhu, Dengbin Wang, Zhigang Chen
The conventional blue Te nanostructures exhibit strong photoabsorption in the near-infrared (NIR) region but have ultralong lengths (tenths of micrometers), while purple Te nanostructures with short lengths (such as nanodots and nanorods) show extremely low intensity of the NIR band. These Te nanostructures cannot achieve simultaneously both the suitable size and high NIR absorption, undoubtedly hindering their bioapplication. Herein, blue Te nanoneedles are prepared through a facile one-pot reduction route for the first time, and they have strong NIR absorbance while maintaining the shortened length (<500 nm)...
August 30, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30152602/an-additive-to-pmma-bone-cement-enables-postimplantation-drug-refilling-broadens-range-of-compatible-antibiotics-and-prolongs-antimicrobial-therapy
#14
Erika L Cyphert, Greg D Learn, Sara K Hurley, Chao-Yi Lu, Horst A von Recum
Poly(methyl methacrylate) (PMMA) bone cement is used in several biomedical applications including as antibiotic-filled beads, temporary skeletal spacers, and cement for orthopedic implant fixation. To mitigate infection following surgery, antibiotics are often mixed into bone cement to achieve local delivery. However, since implanted cement is often structural, incorporated antibiotics must not compromise mechanical properties; this limits the selection of compatible antibiotics. Furthermore, antibiotics cannot be added to resolve future infections once cement is implanted...
August 28, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30146770/magnetic-resonance-imaging-guided-drug-delivery-to-breast-cancer-stem-like-cells
#15
Yujin Sun, Hoe Suk Kim, Sukmo Kang, Yin Ji Piao, Sangyong Jon, Woo Kyung Moon
The feasibility of detecting breast cancer stem-like cells (BCSCs) with magnetic resonance imaging using extradomain-B of fibronectin (EDB-FN)-specific peptide (APTEDB )-conjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (APTEDB -TCL-SPIONs) is previously demonstrated. Here, doxorubicin (Dox)-loaded APTEDB -TCL-SPIONs (Dox@APTEDB -TCL-SPIONs) are generated and their theranostic ability in a BCSC xenograft mouse model is assessed. The Dox@APTEDB -TCL-SPIONs enable more efficient delivery of Dox to tumors than nontargeted Dox@TCL-SPIONs...
August 26, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30146758/tissue-engineered-constructs-for-periodontal-regeneration-current-status-and-future-perspectives
#16
REVIEW
Cedryck Vaquette, Sophia P Pilipchuk, P Mark Bartold, Dietmar W Hutmacher, William V Giannobile, Saso Ivanovski
The periodontium, consisting of gingiva, periodontal ligament, cementum, and alveolar bone, is a hierarchically organized tissue whose primary role is to provide physical and mechanical support to the teeth. Severe cases of periodontitis, an inflammatory condition initiated by an oral bacterial biofilm, can lead to significant destruction of soft and hard tissues of the periodontium and result in compromised dental function and aesthetics. Although current treatment approaches can limit the progression of the disease by controlling the inflammatory aspect, complete periodontal regeneration cannot be predictably achieved...
August 26, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30137689/self-assembled-fluorescent-organic-nanomaterials-for-biomedical-imaging
#17
REVIEW
Kuo Zhang, Yu-Juan Gao, Pei-Pei Yang, Guo-Bin Qi, Jing-Ping Zhang, Lei Wang, Hao Wang
Fluorescent nanomaterials, self-assembled from building blocks through multiple intermolecular interactions show diversified structures and functionalities, and are potential fluorescence contrast agents/probes for high-performance biomedical imaging. Self-assembled nanomaterials exhibit high stability, long circulation time, and targeted biological distribution. This review summarizes recent advances of self-assembled nanomaterials as fluorescence contrast agents/probes for biomedical imaging. The self-assembled nanomaterials are classified into two groups, i...
August 23, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30118580/bisphosphonate-functionalized-gadolinium-oxide-nanoparticles-allow-long-term-mri-ct-multimodal-imaging-of-calcium-phosphate-bone-cement
#18
Simone Mastrogiacomo, Alicja E Kownacka, Weiqiang Dou, Benjamin P Burke, Rafael T M de Rosales, Arend Heerschap, John A Jansen, Stephen J Archibald, X Frank Walboomers
Direct in vivo monitoring of bioconstructs using noninvasive imaging modalities such as magnetic resonance imaging (MRI) or computed tomography (CT) is not possible for many materials. Calcium phosphate-based composites (CPCs) that are applicable to bone regeneration are an example where the materials have poor MRI and CT contrast; hence, they are challenging to detect in vivo. In this study, a CPC construct is designed with gadolinium-oxide nanoparticles incorporated to act as an MRI/CT multimodal contrast agent...
August 17, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30118576/remote-controlling-potassium-channels-in-living-cells-through-photothermal-inactivation-of-calmodulin
#19
Ran Chai, Chengfen Xing, Dong Gao, Hongbo Yuan, Yong Zhan, Shu Wang
Spatiotemporal regulation of cellular functions provides a powerful strategy for understanding underlying mechanisms of cellular bioprocesses. Here, a strategy is reported to realize the remote control of the activities of potassium channels via photothermal inactivation of calmodulin (CaM) by using reduced graphene oxide decorated with calmodulin binding peptide (rGO-P) as the transducer with near-infrared light (NIR) irradiation. Upon NIR light irradiation, the CaM/Ca2+ bound to rGO-P is inactivated by the photothermal effect of rGO-P, resulting in the incapability of binding with Ca2+ ...
August 17, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30118185/diatom-silica-for-biomedical-applications-recent-progress-and-advances
#20
REVIEW
Shaheer Maher, Tushar Kumeria, Moom Sin Aw, Dusan Losic
Diatoms are unicellular photosynthetic algae enclosed in porous 3D nanopatterned silica enclosures called "frustules." The diatom frustules are made from biosilica self-assembled into intricate porous shells that feature unique properties including high specific surface area, biocompatibility, tailorable surface chemistry, thermal stability, and high mechanical and chemical resistance. The ability to cultivate diatoms in artificial environments and their abundant availability of diatom frustules as mineable fossilized mineral deposits (diatomite or diatomaceous earth; DE) make diatom silica a promising natural alternative to synthetic porous silica for a broad range of biomedical, environmental, agricultural, and energy applications...
August 17, 2018: Advanced Healthcare Materials
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