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Advanced Healthcare Materials

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https://www.readbyqxmd.com/read/29785773/molecular-tension-probes-to-investigate-the-mechanopharmacology-of-single-cells-a-step-toward-personalized-mechanomedicine
#1
Kornelia Galior, Victor Pui-Yan Ma, Yang Liu, Hanquan Su, Nusaiba Baker, Reynold A Panettieri, Cherry Wongtrakool, Khalid Salaita
Given that dysregulation of mechanics contributes to diseases ranging from cancer metastasis to lung disease, it is important to develop methods for screening the efficacy of drugs that target cellular forces. Here, nanoparticle-based tension sensors are used to quantify the mechanical response of individual cells upon drug treatment. As a proof-of-concept, the activity of bronchodilators is tested on human airway smooth muscle cells derived from seven donors, four of which are asthmatic. It is revealed that airway smooth muscle cells isolated from asthmatic donors exhibit greater traction forces compared to the control donors...
May 22, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29782706/biological-stimulus-driven-assembly-disassembly-of-functional-nanoparticles-for-targeted-delivery-controlled-activation-and-bioelimination
#2
REVIEW
Xi Hu, Fangyuan Li, Shuying Wang, Fan Xia, Daishun Ling
Nanoassembly technology has emerged as a powerful tool for targeted drug delivery and provides a basis for fabricating medical theranostic nanosystems. However, it is extremely difficult to concentrate nanoparticles at tumor sites, and the poor target-to-background ratio undoubtedly obstructs the accurate diagnosis and effective therapy of cancerous tissues. Importantly, the addition of biological stimulus-responsive groups to nanoassembly systems can enable a biological stimulus-driven assembly-disassembly mutual switch or structural composition/conformation change, thereby amplifying the imaging signal and/or enhancing the therapeutic effect...
May 21, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29770610/arsenic-trioxide-coated-stent-is-an-endothelium-friendly-drug-eluting-stent
#3
Yinping Zhao, Ruolin Du, Tian Zhou, Dongchuan Yang, Yuhua Huang, Yi Wang, Junli Huang, Xiaoyi Ma, Fugui He, Juhui Qiu, Guixue Wang
An ideal vascular stent would both inhibit in-stent restenosis (ISR) and promote rapid re-endothelialization. In the current study, the performance of arsenic trioxide (ATO)-drug eluting stent (AES) is compared with the bare metal stent, poly-lactic-co-glycolic acid-coating metal stent, and rapamycin-drug eluting stent (RES). In vivo AES is shown to prevent neointimal hyperplasia more efficiently than the others when implanted into the carotid arteries of rabbits. Moreover, AES promotes endothelial cells proliferation and re-endothelialization more quickly than RES...
May 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29766658/ampli-a-construction-set-for-paperfluidic-systems
#4
Elizabeth A Phillips, Anna K Young, Nikolas Albarran, Jonah Butler, Kaira Lujan, Kimberly Hamad-Schifferli, Jose Gomez-Marquez
The design and fabrication of reconfigurable, modular paperfluidics driven by a prefabricated reusable block library, asynchronous modular paperfluidic linear instrument-free (Ampli) block, are reported. The blocks are inspired by the plug-and-play modularity of electronic breadboards that lower prototyping barriers in circuit design. The resulting biochemical breadboard is a paperfluidic construction set that can be functionalized with chemical, biological, and electrical elements. Ampli blocks can form standard paperfluidic devices without any external instrumentation...
May 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29761649/polyphenol-poloxamer-self-assembled-supramolecular-nanoparticles-for-tumor-nirf-pet-imaging
#5
Xinyu Wang, Junjie Yan, Donghui Pan, Runlin Yang, Lizhen Wang, Yuping Xu, Jie Sheng, Yuanyuan Yue, Qianhuan Huang, Yanting Wang, Rongrong Wang, Min Yang
Self-assembled supramolecular nanoparticles have remarkable benefits in bioimaging and drug delivery. Here it is first reported that polyphenol and poloxamer self-assemble supramolecular nanoparticles (PPNPs). PPNPs are fabricated by multivalent hydrogen bonding between tannic acid and Pluronic F-127 together with hydrophobic interactions of poly(propylene oxide) chains, to be applied in tumor near-infrared fluorescence (NIRF) imaging and positron emission tomography (PET) imaging. With near-infrared fluorescent dyes such as IR780 encapsulated via hydrophobic interactions, PPNPs are used in NIRF imaging...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29761648/poly-%C3%AE-amino-ester-co-poly-caprolactone-terpolymers-as-nonviral-vectors-for-mrna-delivery-in-vitro-and-in-vivo
#6
Umberto Capasso Palmiero, James C Kaczmarek, Owen S Fenton, Daniel G Anderson
The production of new proteins with messenger RNA (mRNA) has gained a broad interest due to its potential for addressing a wide range of diseases. Here, the design and characterization of novel ionizable poly(β-amino ester)-co-poly(caprolactone) terpolymers, synthesized via the combination of the ring opening polymerization and the Michael step-growth polymerization, are reported. The versatility of this method is demonstrated by varying the number of caprolactone units attached to each poly(β-amino ester) (PBAE) terpolymer...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29761643/fluorescent-2d-ws-2-nanosheets-bearing-chemical-affinity-elements-for-the-recognition-of-glycated-hemoglobin
#7
Jin-Kyoung Yang, Hye-Rim Lee, In-Jun Hwang, Hye-In Kim, DaBin Yim, Jong-Ho Kim
It is required to exfoliate and functionalize 2D transition metal dichalcogenides (TMDs) in an aqueous solution for biological and medical applications. Herein, the approach for the simultaneous exfoliation and functionalization of 2D WS2 nanosheets using boronic acid-modified poly(vinyl alcohol) (B-PVA) in an aqueous solution is reported, and the B-PVA-functionalized WS2 nanosheets (B-PVA-WS2 ) are exploited as a fluorescent biosensor for the detection of glycated hemoglobin, HbA1c. The synthetic B-PVA polymer facilitates the exfoliation and functionalization of WS2 nanosheets from the bulk counterpart in the aqueous solution via a pulsed sonication process, resulting in fluorescent B-PVA-WS2 nanohybrids with a specific recognition of HbA1c...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29757494/multifunctional-smart-skin-adhesive-patches-for-advanced-health-care
#8
REVIEW
Insol Hwang, Hong Nam Kim, Minho Seong, Sang-Hyeon Lee, Minsu Kang, Hoon Yi, Won Gyu Bae, Moon Kyu Kwak, Hoon Eui Jeong
A skin adhesive patch is the most fundamental and widely used medical device for diverse health-care purposes. Conventional skin adhesive patches have been mainly utilized for routine medical purposes such as wound management, fixation of medical devices, and simple drug release. In contrast to traditional skin adhesive patches, recently developed patches incorporate multiple key functions of bulky medical devices into a thin, flexible patch based on emerging nanomaterials and flexible electronic technologies...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29756275/nitric-oxide-releasing-macromolecular-scaffolds-for-antibacterial-applications
#9
REVIEW
Lei Yang, Evan S Feura, Mona Jasmine R Ahonen, Mark H Schoenfisch
Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO-releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO-releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti-biofilm activity...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29756272/harnessing-human-decellularized-blood-vessel-matrices-and-cellular-construct-implants-to-promote-bone-healing-in-an-ex-vivo-organotypic-bone-defect-model
#10
Stefanie Inglis, Karl Heinrich Schneider, Janos M Kanczler, Heinz Redl, Richard O C Oreffo
Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as a periosteal protective sleeve to enhance bone regeneration in embryonic day 18 chick femurs contained within the PVS and cultured organotypically over a 10 day period. The femurs are inserted into decellularized biocompatibility-tested PVS and maintained in an organotypic culture for a period of 10 days. In femurs containing decellularized PVS, a significant increase in bone volume (p < 0...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29749708/freestanding-fiber-based-wearable-temperature-sensor-with-tunable-thermal-index-for-healthcare-monitoring
#11
Tran Quang Trung, Hoang Sinh Le, Thi My Linh Dang, Sanghyun Ju, Sang Yoon Park, Nae-Eung Lee
Fiber-based sensors integrated on textiles or clothing systems are required for the next generation of wearable electronic platforms. Fiber-based physical sensors are developed, but the development of fiber-based temperature sensors is still limited. Herein, a new approach to develop wearable temperature sensors that use freestanding single reduction graphene oxide (rGO) fiber is proposed. A freestanding and wearable temperature-responsive rGO fiber with tunable thermal index is obtained using simple wet spinning and a controlled graphene oxide reduction time...
May 11, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29749707/automated-expansion-of-primary-human-t-cells-in-scalable-and-cell-friendly-hydrogel-microtubes-for-adoptive-immunotherapy
#12
Haishuang Lin, Qiang Li, Ou Wang, Jack Rauch, Braden Harm, Hendrik J Viljoen, Chi Zhang, Erika Van Wyk, Chi Zhang, Yuguo Lei
Adoptive immunotherapy is a highly effective strategy for treating many human cancers, such as melanoma, cervical cancer, lymphoma, and leukemia. Here, a novel cell culture technology is reported for expanding primary human T cells for adoptive immunotherapy. T cells are suspended and cultured in microscale alginate hydrogel tubes (AlgTubes) that are suspended in the cell culture medium in a culture vessel. The hydrogel tubes protect cells from hydrodynamic stresses and confine the cell mass less than 400 µm (in radial diameter) to ensure efficient mass transport, creating a cell-friendly microenvironment for growing T cells...
May 11, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29745029/amplifying-apoptosis-homing-nanoplatform-for-tumor-theranostics
#13
Heng Zhao, Ping Zhou, Kai Huang, Guang Deng, Zhiguo Zhou, Jing Wang, Mingwei Wang, Yingjian Zhang, Hong Yang, Shiping Yang
Nanomedicine has significantly impacted cancer theranostics. However, its efficiency is restricted by the limited enhanced permeability and retention effect of nanomaterials and insufficient density/specificity of receptors of tumor cells. Herein, an apoptosis-homing nanoplatform based on zinc(II) dipicolylamine (ZnDPA) conjugated Fe/Fe3 O4 nanoparticles (MNPs/ZnDPA), which demonstrates amplified magnetic resonance signal and photothermal therapy, is developed. In an apoptotic xenograft model constructed by doxorubicin, due to the high affinity between ZnDPA and the upregulated level of phosphatidylserine on the outer surface of apoptotic cancer cells, the accumulation value of MNPs/ZnDPA is enhanced two-fold and the tumor/muscle ratio of T2 values is decreased to 50% compared to that in the normal xenograft model...
May 10, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29737043/bioreactors-for-cardiac-tissue-engineering
#14
REVIEW
Jesus Paez-Mayorga, Gustavo Hernández-Vargas, Guillermo U Ruiz-Esparza, Hafiz M N Iqbal, Xichi Wang, Yu Shrike Zhang, Roberto Parra-Saldivar, Ali Khademhosseini
The advances in biotechnology, biomechanics, and biomaterials can be used to develop organ models that aim to accurately emulate their natural counterparts. Heart disease, one of the leading causes of death in modern society, has attracted particular attention in the field of tissue engineering. To avoid incorrect prognosis of patients suffering from heart disease, or from adverse consequences of classical therapeutic approaches, as well as to address the shortage of heart donors, new solutions are urgently needed...
May 8, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29732735/tissue-engineering-at-the-blood-contacting-surface-a-review-of-challenges-and-strategies-in-vascular-graft-development
#15
REVIEW
Daniel Radke, Wenkai Jia, Dhavan Sharma, Kemin Fena, Guifang Wang, Jeremy Goldman, Feng Zhao
Tissue engineered vascular grafts (TEVGs) are beginning to achieve clinical success and hold promise as a source of grafting material when donor grafts are unsuitable or unavailable. Significant technological advances have generated small-diameter TEVGs that are mechanically stable and promote functional remodeling by regenerating host cells. However, developing a biocompatible blood-contacting surface remains a major challenge. The TEVG luminal surface must avoid negative inflammatory responses and thrombogenesis immediately upon implantation and promote endothelialization...
May 7, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29732715/evaporative-cooling-hydrogel-packaging-for-storing-biologics-outside-of-the-cold-chain
#16
Shiran Ferber, Adam M Behrens, Kevin J McHugh, Evan M Rosenberg, Allison R Linehan, James L Sugarman, Hapuarachchige Surangi N Jayawardena, Robert Langer, Ana Jaklenec
Stabilizing thermolabile pharmaceuticals outside of the cold chain has the potential to alleviate some of the logistical and monetary burden of providing health care access in the developing world. Evaporative cooling hydrogel packaging is designed to extend the storage stability of existing pharmaceutical products without the need for reformulation. Hydrogels with high water content and reversible hydrophilicity offer a promising platform for reducing storage temperatures without refrigeration. As a model, poly(N-isopropylacrylamide) is selected as a basis for creating a potentially low cost and easy-to-fabricate hydrogels...
May 7, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29726118/gold-nanoparticles-in-radiotherapy-and-recent-progress-in-nanobrachytherapy
#17
REVIEW
Myriam Laprise-Pelletier, Teresa Simão, Marc-André Fortin
Over the last few decades, gold nanoparticles (GNPs) have emerged as "radiosensitizers" in oncology. Radiosensitizers are additives that can enhance the effects of radiation on biological tissues treated with radiotherapy. The interaction of photons with GNPs leads to the emission of low-energy and short-range secondary electrons, which in turn increase the dose deposited in tissues. In this context, GNPs are the subject of intensive theoretical and experimental studies aiming at optimizing the parameters leading to greater dose enhancement and highest therapeutic effect...
May 4, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29719138/mannose-and-mannose-6-phosphate-receptor-targeted-drug-delivery-systems-and-their-application-in-cancer-therapy
#18
REVIEW
Elena Dalle Vedove, Gabriella Costabile, Olivia M Merkel
In order to overcome the main disadvantages of conventional cancer therapies, which prove to be inadequate because of their lack of selectivity, the development of targeted delivery systems is one of the main focuses in anticancer research. It is repeatedly shown that decorating the surface of nanocarriers with high-affinity targeting ligands, such as peptides or small molecules, is an effective way to selectively deliver therapeutics by enhancing their specific cellular uptake via the binding between a specific receptor and the nanosystems...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29719137/real-time-imaging-of-brain-tumor-for-image-guided-surgery
#19
REVIEW
Shuang Hu, Homan Kang, Yoonji Baek, Georges El Fakhri, Anren Kuang, Hak Soo Choi
The completion of surgical resection is a key prognostic factor in brain tumor treatment. This requires surgeons to identify residual tumors in theater as well as to margin the proximity of the tumor to adjacent normal tissue. Subjective assessments, such as texture palpation or visual tissue differences, are commonly used by oncology surgeons during resection to differentiate cancer lesions from normal tissue, which can potentially result in either an incomplete tumor resection, or accidental removal of normal tissue...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29719134/an-intelligent-neural-stem-cell-delivery-system-for-neurodegenerative-diseases-treatment
#20
Shupei Qiao, Yi Liu, Fengtong Han, Mian Guo, Xiaolu Hou, Kangruo Ye, Shuai Deng, Yijun Shen, Yufang Zhao, Haiying Wei, Bing Song, Lifen Yao, Weiming Tian
Transplanted stem cells constitute a new therapeutic strategy for the treatment of neurological disorders. Emerging evidence indicates that a negative microenvironment, particularly one characterized by the acute inflammation/immune response caused by physical injuries or transplanted stem cells, severely impacts the survival of transplanted stem cells. In this study, to avoid the influence of the increased inflammation following physical injuries, an intelligent, double-layer, alginate hydrogel system is designed...
May 2, 2018: Advanced Healthcare Materials
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