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Respiratory Investigation

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https://www.readbyqxmd.com/read/29153420/the-additive-effect-of-clarithromycin-on-influenza-a-infection-in-the-elderly-patients-and-patients-with-comorbid-diseases
#1
Kazuhiro Yatera, Kenji Umeki, Kei Yamasaki, Shingo Noguchi, Chinatsu Nishida, Hiroshi Ishimoto, Noriho Sakamoto, Hiroshi Ishii, Jun-Ichi Kadota, Hiroshi Mukae
No abstract text is available yet for this article.
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153419/health-checkup-system-and-pulmonary-nontuberculous-mycobacterial-disease
#2
Toshihiko Fukuoka, Kozo Morimoto, Tomoyuki Ogata, Kazuhiro Uchimura
No abstract text is available yet for this article.
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153418/long-term-complete-response-to-carboplatin-plus-paclitaxel-combined-with-bevacizumab-in-a-patient-with-metastatic-spindle-cell-carcinoma
#3
Shinya Sakata, Sho Saeki, Ryo Sato, Shiho Ishizuka, Jiichiro Sasaki, Kazuhiko Fujii
We report the case of a 62-year-old Japanese male with metastatic spindle cell carcinoma (SpCC) who showed a long-term complete response (CR) to bevacizumab combination chemotherapy. We performed chemotherapy with carboplatin (AUC 6, day 1) plus paclitaxel (200mg/m(2), day 1) plus bevacizumab (15mg/kg, day 1) for four cycles. After the chemotherapy, CT imaging demonstrated a CR. We subsequently administered bevacizumab (15mg/kg) repeated every 3 weeks as maintenance therapy for 12 cycles. The patient discontinued maintenance chemotherapy because of grade 3 proteinuria, but the anti-tumor effect of CR was maintained at 35 months after the discontinuation of chemotherapy...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153417/the-efficacy-of-transbronchial-needle-aspiration-with-endobronchial-ultrasonography-using-a-guide-sheath-for-peripheral-pulmonary-lesions-suspected-to-be-lung-cancer
#4
Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Akitoshi Sato, Mizue Hasegawa, Hideki Katsura, Etsuko Tagaya, Mitsuko Kondo, Jun Tamaoki
BACKGROUND: The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs. METHODS: We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153416/frequency-of-detection-of-chlamydophila-pneumoniae-using-bronchoalveolar-lavage-fluid-in-patients-with-community-onset-pneumonia
#5
Shingo Noguchi, Kazuhiro Yatera, Toshinori Kawanami, Kazumasa Fukuda, Kei Yamasaki, Keisuke Naito, Kentaro Akata, Hiroshi Ishimoto, Hiroshi Mukae
BACKGROUND: Chlamydophila pneumoniae is a causative pathogen of lower respiratory tract infection, which generally infects healthy, young people. However, it is often difficult to evaluate acute C. pneumoniae infection using upper respiratory tract specimens and/or sputum samples due to its persistent infection or colonization. The interpretation of frequency of detection of C. pneumoniae seems to be insufficient in community-onset pneumonia. The aim of this study was to evaluate the presence of C...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153415/comparison-of-the-rapid-effects-of-single-inhalations-of-formoterol-and-tiotropium-bromide-on-respiratory-function-and-copd-symptoms-in-a-randomized-crossover-study
#6
Hiroyuki Ohbayashi
BACKGROUND: This study aimed to compare rapid improvements in respiratory function and symptoms following single inhalation of formoterol (FOM) dry power inhaler (DPI) or tiotropium bromide (TIO) DPI in patients with chronic obstructive pulmonary disease (COPD). METHODS: Fifty-two outpatients with COPD (GOLD stage 2 or 3) received either a single inhalation of FOM DPI (9 μg via a Turbuhaler®) or TIO DPI (18μg via a HandiHaler®) in a randomized crossover manner...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153414/association-of-interleukin-1-receptor-like-1-gene-polymorphisms-with-eosinophilic-phenotype-in-japanese-adults-with-asthma
#7
Hideki Inoue, Isao Ito, Akio Niimi, Hisako Matsumoto, Tsuyoshi Oguma, Tomoko Tajiri, Toshiyuki Iwata, Tadao Nagasaki, Yoshihiro Kanemitsu, Toshitaka Morishima, Tomomitsu Hirota, Mayumi Tamari, Sally E Wenzel, Michiaki Mishima
BACKGROUND: IL1RL1 (ST2) is involved in Th2 inflammation including eosinophil activation. Single nucleotide polymorphisms (SNPs) of the IL1RL1 gene are associated with asthma development and increased peripheral blood eosinophil counts. However, the association between IL1RL1 SNPs and eosinophilic phenotype among adults with asthma remains unexplored. METHODS: In a primary cohort of 110 adult Japanese patients with stable asthma, we examined the associations between IL1RL1 SNPs and clinical measurements including forced expiratory volume (FEV1), airway reversibility of FEV1, exhaled nitric oxide (FeNO), serum soluble-ST2 (sST2) levels, peripheral blood eosinophil differentials and serum total IgE level...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153413/an-objective-evaluation-of-nocturnal-cough-count-and-cough-pattern-in-children-with-psychogenic-cough
#8
Eri Imai, Kota Hirai, Yoshiko Mikami, Mariko Nukaga, Mayumi Enseki, Hideyuki Tabata, Masahiko Kato, Hiroyuki Mochizuki
Two patients with a chronic, barking cough were diagnosed with psychogenic cough. Using an original cough counter we studied the nocturnal cough count and pattern. While the number of coughs when awake was extremely high for both patients, the number of coughs was remarkably reduced during sleep, similar to an exacerbation of asthma. Moreover, the properties of the coughs when awake were clearly different from those of coughs during sleep. In conclusion, an objective examination using a cough counter was useful for the diagnosis, treatment and management of psychogenic cough...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153412/role-of-lung-volume-and-airway-inflammation-in-obstructive-sleep-apnea
#9
REVIEW
Andras Bikov, Gyorgy Losonczy, Laszlo Kunos
Obstructive sleep apnea (OSA) is a prevalent disorder that affects not only the upper airways but also the intrathoracic airways. In this review, we summarize the results of studies on lung function and airway inflammation. We provide evidence that the alterations in intrathoracic airways observed in OSA are not purely consequences of mechanical trauma and oxidative stress during apneic events but have a causal role in the structural changes associated with OSA and increasing severity of this disorder.
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153411/how-do-we-critically-use-long-acting-muscarinic-receptor-antagonists-and-beta-adrenergic-receptor-agonists-monotherapy-or-these-combination-therapies-depending-on-the-situation-in-japanese-patients-with-copd
#10
EDITORIAL
https://www.readbyqxmd.com/read/28942888/direct-hemoperfusion-with-polymyxin-b-immobilized-fiber-for-the-treatment-of-the-acute-exacerbation-of-idiopathic-pulmonary-fibrosis-in-patients-requiring-invasive-mechanical-ventilation
#11
Masamichi Komatsu, Tsutomu Hachiya, Hidekazu Takahashi, Sawako Yoshikawa, Takayuki Honda
The prognosis of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) in individuals undergoing invasive mechanical ventilation is known to be poor. We describe the cases of three men, who were former smokers and required mechanical ventilation, whose AE-IPF was treated with direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP). In all cases, we successfully weaned the patients from mechanical ventilation. Two of the patients survived for more than 180 days after development of AE-IPF...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942887/bronchoscopic-diagnosis-of-peripheral-pulmonary-lung-cancer-employing-sedation-with-fentanyl-and-midazolam
#12
Daisuke Minami, Takamasa Nakasuka, Chihiro Ando, Yoshitaka Iwamoto Md, Ken Sato, Keiichi Fujiwara, Takuo Shibayama, Toshirou Yonei Md PhD, Toshio Sato
BACKGROUND: Sedation with fentanyl and midazolam during bronchoscopic examination is commonly employed by pulmonary physicians in the USA and Europe. We assessed the efficacy of such sedation in the bronchoscopic diagnosis of peripheral lung cancer. METHODS: We retrospectively evaluated data from 102 patients who underwent transbronchial biopsies (TBB) for diagnosis of peripheral lung cancer. Bronchoscopies with and without fentanyl were performed in 61 (group A) and 41 (group B) patients, respectively...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942886/who-treats-lung-cancer-results-from-a-global-survey
#13
Takefumi Komiya, Christine B Mackay, Prabhakar Chalise
BACKGROUND: In most Western nations, the medical oncologist plays a significant role in the administration of systemic therapy for lung cancer. In Japan however, treatment for lung cancer has historically been provided by pulmonologists and thoracic surgeons. A comparison of the management of advanced disease between Japan and other nations has not been described. METHODS: An online, self-administered, international survey was sent to 3907 active members of the American Society of Clinical Oncology...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942885/mosaic-attenuation-pattern-in-non-contrast-computed-tomography-for-the-assessment-of-pulmonary-perfusion-in-chronic-thromboembolic-pulmonary-hypertension
#14
Hajime Kasai, Nobuhiro Tanabe, Kazushi Fujimoto, Hiromasa Hoshi, Jun Naito, Ryuto Suzuki, Akane Matsumura, Toshihiko Sugiura, Seiichiro Sakao, Koichiro Tatsumi
BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is difficult to diagnose as patients rarely present with specific symptoms. However, a mosaic attenuation pattern (MAP) in chest computed tomography (CT) suggests CTEPH. Areas of increased attenuation are not always visible using default CT settings for the lung. Thus, we examined the utility of non-contrast CT imaging with new settings focusing on MAP (CTMosaic) for the assessment of pulmonary perfusion in patients with CTEPH...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942884/overexpression-of-il-38-protein-in-anticancer-drug-induced-lung-injury-and-acute-exacerbation-of-idiopathic-pulmonary-fibrosis
#15
Masaki Tominaga, Masaki Okamoto, Tomotaka Kawayama, Masanobu Matsuoka, Shinjiro Kaieda, Yuki Sakazaki, Takashi Kinoshita, Daisuke Mori, Akira Inoue, Tomoaki Hoshino
BACKGROUND: Interleukin (IL)-38, a member of the IL-1 family, shows high homology to IL-1 receptor antagonist (IL-1Ra) and IL-36 receptor antagonist (IL-36Ra). Its function in interstitial lung disease (ILD) is still unknown. METHODS: To determine the expression pattern of IL-38 mRNA, a panel of cDNAs derived from various tissues was analyzed by quantitative real-time PCR. Immunohistochemical reactivity with anti-human IL-38 monoclonal antibody (clone H127C) was evaluated semi-quantitatively in lung tissue samples from 12 patients with idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), 5 with acute exacerbation of IPF, and 10 with anticancer drug-induced ILD (bleomycin in 5 and epidermal growth factor receptor-tyrosine kinase inhibitor in 5)...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942883/gastroesophageal-reflux-disease-an-important-consideration-for-respiratory-disorders
#16
EDITORIAL
Akio Niimi
No abstract text is available yet for this article.
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942882/respiratory-sleep-medicine-along-with-conventional-medicine-aids-in-healthy-life-expectancy
#17
EDITORIAL
Kazuo Chin
No abstract text is available yet for this article.
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28705309/comparison-of-the-aerosol-velocity-of-two-respimat-%C3%A2-soft-mist-inhalers-and-two-pressurized-metered-dose-inhalers-for-short-acting-muscarinic-antagonists
#18
LETTER
https://www.readbyqxmd.com/read/28705308/primary-sj%C3%A3-gren-s-syndrome-with-waldenstr%C3%A3-m-s-macroglobulinemia-presenting-as-unilateral-bloody-pleural-effusion
#19
Yasuhiko Koga, Kazuhiko Uchiyama Md, Norifumi Tsukamoto Md PhD, Nobuyuki Shibusawa Md PhD, Mitsuyoshi Utsugi Md PhD, Satoru Kakizaki Md PhD, Junko Hirato Md PhD, Kunio Dobashi Md PhD, Takeshi Hisada Md PhD, Masanobu Yamada Md PhD
No abstract text is available yet for this article.
July 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28705307/a-new-method-for-enhanced-expectoration-of-sputum-by-vibratory-stimulation-of-the-cervical-trachea
#20
RANDOMIZED CONTROLLED TRIAL
Mitsuhiro Kamimura, Nobuhisa Kameyama, Chie Homma, Tatsuya Ibe, Shinjiro Takeoka, Atsuto Mouri, Yoichiro Hamamoto
BACKGROUND: Expectoration of sputum can be difficult for patients with respiratory conditions such as chronic obstructive pulmonary disease, chronic bronchitis, or bronchiectasis because of the effects of decreased pulmonary function, respiratory muscle fatigue, altered sputum properties, and impaired ciliary function. We developed a new method for the vibratory stimulation of the cervical trachea and this study aimed to compare it with the Acapella (a current oscillation device) method...
July 2017: Respiratory Investigation
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