Read by QxMD icon Read

Respiratory Investigation

Satoshi Sakamoto, Masaki Okamoto, Shinjiro Kaieda, Kiminori Fujimoto, Shuji Nagata, Masaki Tominaga, Masayuki Nakamura, Yoshiaki Zaizen, Takashi Nouno, Takuma Koga, Tomotaka Kawayama, Masataka Kuwana, Hiroaki Ida, Tomoaki Hoshino
BACKGROUND: Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab) is associated with fatal rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). We attempted to clarify whether anti-MDA5-Ab is associated with long-term outcomes in patients with DM-ILD. METHODS: Thirty-six patients with DM-ILD were retrospectively analyzed for their serum anti-MDA5-Ab by using an enzyme-linked immunosorbent assay. We analyzed the association between clinical parameters, including the serum levels of anti-MDA5-Ab and ferritin...
August 24, 2018: Respiratory Investigation
Kazuto Matsunaga
No abstract text is available yet for this article.
August 24, 2018: Respiratory Investigation
Susumu Hirosako, Kazuyoshi Nakamura, Shohei Hamada, Kazuaki Sugahara, Chieko Yoshida, Sho Saeki, Keisuke Kojima, Shinichiro Okamoto, Hidenori Ichiyasu, Kazuhiko Fujii, Hirotsugu Kohrogi
BACKGROUND: Due to advances in medicine, patients with pulmonary diseases have become candidates for surgery under general anesthesia. They often consult pulmonologists to assess their tolerability for surgery. The purpose of this study was to evaluate the significant characteristics responsible for postoperative pulmonary complications (PPCs) and the preclusion of the planned surgery. METHODS: The clinical data of 462 consecutive patients who consulted at the Department of Respiratory Medicine before surgery under general anesthesia were used in this study...
August 23, 2018: Respiratory Investigation
Miharu Kato, Yumiko Kanehiro, Kaku Yoshimi, Yuzo Kodama, Mitsuaki Sekiya, Tadashi Sato, Kazuhisa Takahashi, Kuniaki Seyama
BACKGROUND: Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease that causes an obstructive ventilatory impairment similar to chronic obstructive pulmonary disease (COPD) and impairs the health-related quality of life (HRQoL). Here, we extended the use of the COPD assessment test (CAT) to patients with chronic respiratory diseases other than COPD. Specifically, the CAT was administered to patients with LAM for the first time. METHODS: Using data from 25 patients with LAM at Juntendo University who participated in the Multicenter Lymphangioleiomyomatosis Sirolimus Trial for Safety (MLSTS), we evaluated changes in pulmonary function, responses to HRQoL questionnaires (the CAT, St...
August 21, 2018: Respiratory Investigation
Masako To, Akihiro Hitani, Yuta Kono, Natsue Honda, Ichino Kano, Kosuke Haruki, Yasuo To
BACKGROUND: Severe asthma is increasingly being recognized as an important public health issue. Obesity has been identified as a risk factor for poor asthma control and for worsening of asthma severity. However, most studies investigating obese patients with asthma have been performed in Western countries. Reports on the characteristics of obese Japanese individuals with severe asthma are lacking. Herein, we investigated the clinical characteristics of patients with obesity-associated severe asthma in a Japanese population and the association between obesity and poor asthma control...
August 9, 2018: Respiratory Investigation
Naoto Ishimaru, Hisashi Ohnishi, Sho Yoshimura, Saori Kinami
OBJECTIVE: To assess the sensitivities of the Wells score (WS) and the revised Geneva score (RGS) and their prognostic values in the diagnosis of pulmonary embolism (PE) in the Japanese population. METHODS: We conducted a retrospective chart review of patients with PE aged 16 years or older who were assessed between December 2008 and August 2014. Patients were divided into the PE unlikely and PE likely groups according to the WS and PE unlikely and PE likely groups according to the RGS...
September 2018: Respiratory Investigation
Shigeki Saito, Joseph A Lasky, Koichi Hagiwara, Yasuhiro Kondoh
Epidemiologic data suggest that there are ethnic differences between Japanese and other populations with regard to the important clinical aspects of interstitial lung disease (ILD), such as the cause of death and prognostic factors in patients with idiopathic pulmonary fibrosis (IPF). Acute exacerbation (AE) of IPF may be more common in Japan than in the rest of the world, although this suggestion remains controversial. Moreover, AE of ILD induced by gefitinib may also be more common in Japan, indicating that Japanese patients have a genetic vulnerability or susceptibility to AE...
September 2018: Respiratory Investigation
Osamu Takakuwa, Tetsuya Oguri, Takamitsu Asano, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Akio Niimi
BACKGROUND: Hypoxemia during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is often encountered even in patients without respiratory impairment before the procedure. The aim of this study was to evaluate the efficacy of a high-flow nasal cannula (HFNC) in preventing hypoxemia during EBUS-TBNA. METHODS: The present investigation was designed as a prospective pilot study. Eligible subjects were adults who could undergo EBUS-TBNA under intravenous midazolam sedation...
September 2018: Respiratory Investigation
Takefumi Komiya, Achuta K Guddati, Gerard Chaaya
No abstract text is available yet for this article.
September 2018: Respiratory Investigation
Jiro Fujita
No abstract text is available yet for this article.
September 2018: Respiratory Investigation
Koichiro Kamio, Arata Azuma
No abstract text is available yet for this article.
September 2018: Respiratory Investigation
Satoshi Takeda, Nobuhiko Nagata, Yuji Yoshida, Takemasa Matsumoto, Takashi Aoyama, Taishi Harada, Hiroyuki Miyazaki, Takanori Akagi, Shinichiro Ushijima, Hiroshi Yatsugi, Senichiro Mori, Kenji Wada, Daisuke Hamatake, Toshihiko Moroga, Masaki Fujita, Kentaro Watanabe
BACKGROUND: Small-bore aspiration catheters (Aspiration Kit® ) cause less pain than conventional trocar catheters in patients. The objective of this study was to examine the usefulness of these less invasive small-bore aspiration catheters for drainage of pneumothorax. METHODS: Baseline characteristics and laboratory test data at admission of 70 patients who were admitted to and underwent drainage treatment for pneumothorax at our hospital between April 2011 and February 2017 were retrospectively reviewed based on their medical records...
September 2018: Respiratory Investigation
Hirofumi Chiba, Mitsuo Otsuka, Hiroki Takahashi
Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible condition with poor prognosis that is characterized by a variable clinical course in each patient, which renders it a complex disease with unknown causes. Despite the proven efficacy of novel antifibrotic therapies, including pirfenidone and nintedanib, the diagnosis and follow-up of IPF remain challenging. Hence, the identification of molecular biomarkers for early detection of IPF and to predict biologically determined individual clinical courses, has recently piqued the interest of researchers...
September 2018: Respiratory Investigation
Mariko Nukaga, Hideyuki Tabata, Mayumi Enseki, Kota Hirai, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND: Breath sound parameters have been suggested to be new biomarkers of airway function in patients with asthma. METHODS: We investigated the effect of bronchodilation on breath sound parameters in sixty-four children (mean age, 8.9 years; range, 6-16 years) using a breath sound analyzer. The breath sound parameters included frequency limiting 50% and 99% of the power spectrum (F50 and F99 ), roll-off from 600-1200 Hz (slope), and spectrum curve indices such as the ratios of the third and fourth power area to the total area of the power spectrum (P3 /PT and P4 /PT ), total area under the curve (A3 /AT and B4 /AT ), and the ratio of power and frequency at 50% and 75% of the highest frequency of the power spectrum (RPF75 and RPF50 )...
September 2018: Respiratory Investigation
Kazumasa Ogawa, Yui Takahashi, Kyoko Murase, Shigeo Hanada, Hironori Uruga, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Atsuko Kurosaki, Kazuma Kishi
BACKGROUND: Pneumothorax occasionally develops in patients with interstitial pneumonia (IP) and is often intractable. As there exists no well-established treatment for pneumothorax with IP, we evaluated the efficacy and safety of pleurodesis with OK-432, a lyophilized preparation of Streptococcus pyogenes Su strain that has been inactivated by benzylpenicillin. METHODS: We retrospectively evaluated the efficacy and safety of pleurodesis using OK-432 in 39 patients treated for IP-related pneumothorax between January 2006 and May 2017...
September 2018: Respiratory Investigation
Masahiro Shimada, Atsuhisa Tamura, Kyoko Yokosuka, Kei Kusaka, Hirotoshi Matsui, Hideaki Nagai, Ken Ohta
BACKGROUND: In current guidelines, the role of immune checkpoint inhibitors is not yet determined in the treatment strategy for NSCLC harboring ALK translocations. CASE: A 51-year-old woman with lung adenocarcinoma harboring ALK translocation was treated with alectinib until PD. After the second (CDDP/PEM) and third (crizotinib) line treatment, a second biopsy was performed, revealing PD-L1 tumor proportion score of 70-80% and G1202R mutation of ALK. Pembrolizumab was selected for the fourth line, leading to PR for more than 6 months...
July 2018: Respiratory Investigation
Nobuhiro Tanabe, Takashi Kawakami, Toru Satoh, Hiromi Matsubara, Norifumi Nakanishi, Hitoshi Ogino, Yuichi Tamura, Ichizo Tsujino, Aiko Ogawa, Seiichiro Sakao, Mari Nishizaki, Keiichi Ishida, Yasunori Ichimura, Masahiro Yoshida, Koichiro Tatsumi
BACKGROUND: Balloon pulmonary angioplasty (BPA) has been performed for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or residual pulmonary hypertension after pulmonary endarterectomy (PEA). We performed a systematic review to assess the efficacy and safety of BPA, especially compared to medical treatment or PEA. METHODS: We reviewed all studies investigating pre- and post-treatment pulmonary hemodynamics, mortality, or complications from three electronic databases (PubMed, Cochrane Library, Japan Medical Abstracts Society) prior to February 2017...
July 2018: Respiratory Investigation
Ram Kumar Mishra, Amit Pagada, Hariprasad Esam
BACKGROUND: Given the well documented and undesired impact of diffuse panbronchiolitis (DPB), there is a need to create a statistical inventory of research output on DPB. The aim of this study was to identify and analyze different trends in publication over time, with technological additions. METHODS: Articles indexed in MEDLINE regarding DPB were retrieved using PubMed. Citation results were categorized by article type, year of publication, language, and country...
July 2018: Respiratory Investigation
Sakae Homma, Masashi Bando, Arata Azuma, Susumu Sakamoto, Keishi Sugino, Yoshiki Ishii, Shinyu Izumi, Naohiko Inase, Yoshikazu Inoue, Masahito Ebina, Takashi Ogura, Kazuma Kishi, Tomoo Kishaba, Takashi Kido, Akihiko Gemma, Yoshihito Goto, Shinichi Sasaki, Takeshi Johkoh, Takafumi Suda, Kazuhisa Takahashi, Hiroki Takahashi, Yoshio Taguchi, Hiroshi Date, Hiroyuki Taniguchi, Takeo Nakayama, Yasuhiko Nishioka, Yoshinori Hasegawa, Noboru Hattori, Junya Fukuoka, Atsushi Miyamoto, Hiroshi Mukae, Akihito Yokoyama, Ichiro Yoshino, Kentaro Watanabe
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology which accounts for a large proportion of cases of idiopathic interstitial pneumonia. It has a very poor prognosis with a 5-year survival rate of 30% or below, and so far there has been no guideline in Japan offering an established effective therapy based on evidence. In addition to the establishment of basic therapies, there is also an urgent need to establish therapies to deal with complications, as death occurs in many cases due to acute exacerbation or comorbid lung cancer...
July 2018: Respiratory Investigation
Koji Chihara
No abstract text is available yet for this article.
July 2018: Respiratory Investigation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"