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Respiratory Investigation

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https://www.readbyqxmd.com/read/28012501/the-japanese-respiratory-society-noninvasive-positive-pressure-ventilation-nppv-guidelines-second-revised-edition
#1
Tsuneto Akashiba, Yuka Ishikawa, Hideki Ishihara, Hideaki Imanaka, Motoharu Ohi, Ryoichi Ochiai, Takatoshi Kasai, Kentaro Kimura, Yasuhiro Kondoh, Shigeru Sakurai, Nobuaki Shime, Masayuki Suzukawa, Misa Takegami, Shinhiro Takeda, Sadatomo Tasaka, Hiroyuki Taniguchi, Naohiko Chohnabayashi, Kazuo Chin, Tomomasa Tsuboi, Keisuke Tomii, Koji Narui, Nobuyuki Hasegawa, Ryuichi Hasegawa, Yoshihito Ujike, Keishi Kubo, Yoshinori Hasegawa, Shin-Ichi Momomura, Yoshitsugu Yamada, Masahiro Yoshida, Yukie Takekawa, Ryo Tachikawa, Satoshi Hamada, Kimihiko Murase
No abstract text is available yet for this article.
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012500/familial-diffuse-pulmonary-ossification-a-possible-genetic-disorder
#2
Yoshiaki Kinoshita, Ichiko Mizuguchi, Kouko Hidaka, Hiroshi Ishii, Kentaro Watanabe
Diffuse pulmonary ossification (DPO) is an uncommon disease that is characterized by the widespread formation of ectopic bone in the lungs. Herein, we describe two familial cases of DPO. The patients were a 47-year-old woman and her 76-year-old father. Both patients had a history of recurrent cough, and their chest images showed multiple nodules with ossification. No underlying diseases that might have caused DPO were evident; however, the female patient also had congenital finger hypoplasia and deformity. The present cases indicate the possibility that DPO might be partly associated with genetic disorders...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012499/possible-relationship-between-organizing-pneumonia-and-chronic-pulmonary-aspergillosis-a-case-report-and-literature-review
#3
Aki Sakurai, Hidekatsu Yanai, Tsuyoshi Ishida, Hiromi Kuwata, Katsuhiko Kamei, Shinyu Izumi
Organizing pneumonia (OP) is a nonspecific response to various forms of lung injury and has been reported in association with several infectious agents. However, little is known about the relationship between OP and chronic pulmonary aspergillosis, and the mechanism of this linkage has not been elucidated. Here, we present a case of chronic pulmonary aspergillosis that led to the development of OP, which was successfully treated with corticosteroid and surgical intervention. In a review of the literature, we aim to highlight the possible relationship between OP and chronic pulmonary aspergillosis...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012498/three-dimensional-imaging-forced-oscillation-technique-to-assess-position-dependent-airway-obstruction-in-relapsing-polychondritis-a-case-report
#4
Takahiro Kamada, Isao Ito, Yoshihiro Kanemitsu, Susumu Sato, Hisako Matsumoto, Akio Niimi, Michiaki Mishima
Relapsing polychondritis (RP) is characterized by recurrent systemic inflammation of the cartilages and is accompanied by central airway collapse. We report a case wherein three-dimensional imaging of respiratory system resistance (Rrs) and respiratory system reactance (Xrs) by using MostGraph (CHEST M.I., Tokyo, Japan), a forced oscillation system, revealed that Rrs and Xrs in the inspiratory and expiratory phases correlated with proximal airway collapse. The degree of difference in Rrs and Xrs between the supine and sitting positions reflected airway collapse more closely than did the pulmonary function test...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012497/giant-bulla-formation-in-the-lung-because-of-a-check-valve-mechanism
#5
Aya Hirata, Takeshi Saraya, Nobuaki Arai, Shin Karita, Riken Kawachi, Hidefumi Takei, Kosuke Ohkuma, Manabu Ishida, Masachika Fujiwara, Hajime Takizawa
The pathogenesis of bulla formation has not yet been demonstrated in pathologic examinations or through direct visualization during thoracotomy or thoracoscopic surgery. We present two cases of giant bulla formation after pneumothorax because of cryptogenic organizing pneumonia and lung abscess. The case findings suggested that the pathogenesis was attributable to a check-valve mechanism, secondary to bronchiolitis obliterans, or the presence of an obstructing air leakage due to a lung fistula. The lung fistula had been covered by inflammatory membranes consisting of blood and/or fibrous precipitates with detached visceral pleura...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012496/an-autopsy-case-of-bronchiolitis-obliterans-as-a-previously-unrecognized-adverse-event-of-afatinib-treatment
#6
Nobuhiro Kanaji, Yoichi Chiba Md PhD, Akira Sato Md PhD, Masaki Ueno Md PhD, Akira Tadokoro Md PhD, Nobuyuki Kita Md, Tomoya Ishii Md PhD, Naoki Watanabe Md, Norimitsu Kadowaki Md PhD, Shuji Bandoh Md PhD
Interstitial lung disease is a well-known pulmonary adverse event that occurs during epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy and results in restrictive ventilatory dysfunction. However, obstructive changes such as those associated with bronchiolitis obliterans (BO) have never been reported as adverse events resulting from the use of any approved EGFR-TKI. This report documents an autopsy case of BO that developed during afatinib treatment for adenocarcinoma of the lung...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012495/does-normal-spirometry-rule-out-an-obstructive-or-restrictive-ventilatory-defect
#7
Spyridon Fortis, Edward O Corazalla, Hyun J Kim
No abstract text is available yet for this article.
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012494/hepatotoxicity-of-nintedanib-in-patients-with-idiopathic-pulmonary-fibrosis-a-single-center-experience
#8
Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Hideaki Yamakawa, Masato Morita, Hideya Kitamura, Takashi Ogura
No abstract text is available yet for this article.
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012493/analysis-of-the-impact-of-lung-cancer-treatment-on-nontuberculous-mycobacterial-lung-diseases
#9
Taisuke Tsuji, Kazunari Tsuyuguchi, Kazunobu Tachibana, Yohei Kimura, Takehiko Kobayashi, Shojiro Minomo, Shinji Atagi, Akihide Matsumura, Seiji Hayashi, Katsuhiro Suzuki
BACKGROUND: Although nontuberculous mycobacteria (NTM) lung diseases can occur in association with lung cancer, no study has evaluated the effect of lung cancer treatment on NTM lung diseases. Therefore, the present study aimed to retrospectively examine the effect of lung cancer treatment on NTM lung diseases. METHODS: Patients diagnosed with NTM lung diseases in combination with cytologically or histologically proven lung cancer between January 1, 2010 and October 31, 2014 were enroled...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012492/guidelines-concordant-empiric-antimicrobial-therapy-and-mortality-in-patients-with-severe-community-acquired-pneumonia-requiring-mechanical-ventilation
#10
Yukiyo Sakamoto, Yasuhiro Yamauchi, Hideo Yasunaga, Hideyuki Takeshima, Wakae Hasegawa, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase
BACKGROUND: Community-acquired pneumonia (CAP) has high morbidity and mortality among adults. Several clinical guidelines recommend prompt administration of combined antimicrobial therapy. However, the association between guidelines concordance and mortality in patients with severe pneumonia remains unclear. The present study aimed to examine the impact of guidelines-concordant empiric antimicrobial therapy on 7-day mortality in patients with extremely severe pneumonia who required mechanical ventilation at admission, using a nationwide inpatient database in Japan...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012491/associations-between-the-distance-covered-in-the-incremental-shuttle-walk-test-and-lung-function-and-health-status-in-patients-with-chronic-obstructive-pulmonary-disease
#11
Atsuhito Ushiki, Shuhei Nozawa, Masanori Yasuo, Kazuhisa Urushihata, Hiroshi Yamamoto, Masayuki Hanaoka, Keisaku Fujimoto
BACKGROUND: Field walk tests such as the incremental shuttle walk test (ISWT) are simple tests for assessing the degree of disability in individuals with chronic obstructive pulmonary disease (COPD). In the present study, the correlations between exercise performance in the ISWT, lung function, and health status were examined in patients with COPD of varying severities. METHODS: A retrospective examination of 277 COPD patients was performed using the ISWT and lung function tests along with assessment of health status using St...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012490/association-of-anti-aminoacyl-transfer-rna-synthetase-antibody-and-anti-melanoma-differentiation-associated-gene-5-antibody-with-the-therapeutic-response-of-polymyositis-dermatomyositis-associated-interstitial-lung-disease
#12
Naomi Yoshida, Masaki Okamoto, Shinjiro Kaieda, Kiminori Fujimoto, Tomohiro Ebata, Morihiro Tajiri, Masayuki Nakamura, Masaki Tominaga, Daisuke Wakasugi, Tomotaka Kawayama, Masataka Kuwana, Tsuneyo Mimori, Hiroaki Ida, Tomoaki Hoshino
BACKGROUND: We attempted to clarify whether the presence of anti-aminoacyl-transfer RNA synthetase antibody (anti-ARS Ab) or anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) is associated with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). METHODS: We retrospectively investigated 22 patients with PM/DM-ILD (10 positive for anti-ARS Ab and nine positive for anti-MDA5 Ab) for whom antibody analysis of conserved serum was possible...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012489/pathognomonic-remodeling-of-blood-and-lymphatic-capillaries-in-idiopathic-pulmonary-fibrosis
#13
REVIEW
Masahito Ebina
Numerous studies have been published investigating the pathologic alterations in various interstitial pneumonias, particularly in idiopathic pulmonary fibrosis (IPF). However, the few existing studies on capillary remodeling, which does not seem to have priority for pathologic diagnosis, are contradictory, with some reporting increased and others reduced vascularization. We hypothesized that these discrepancies were due to the temporal heterogeneity of the lesions in IPF. We subsequently developed original techniques for evaluating vascular density within the alveolar septa and discovered, for the first time, a heterogeneous increase in alveolar capillaries in the lungs of IPF patients...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012488/prognostic-value-of-serial-serum-kl-6-measurements-in-patients-with-idiopathic-pulmonary-fibrosis
#14
Kentaro Wakamatsu, Nobuhiko Nagata, Hiroyuki Kumazoe, Keishi Oda, Hiroshi Ishimoto, Michihiro Yoshimi, Shohei Takata, Minako Hamada, Yoshifusa Koreeda, Kouji Takakura, Miwa Ishizu, Makiko Hara, Shinji Ise, Miiru Izumi, Takashi Akasaki, Sanae Maki, Masaharu Kawabata, Hiroshi Mukae, Masayuki Kawasaki
BACKGROUND: The prognostic significance of serial measurements of serum KL-6 levels in patients with idiopathic pulmonary fibrosis (IPF) is unclear; hence, it was assessed in this study. METHODS: Medical records of 66 patients with IPF, who were not treated with pirfenidone prior to enrollment, were retrospectively reviewed for information on clinical progress, forced vital capacity (FVC), survival, and serum KL-6 levels. We assessed initial serum levels of KL-6, serial changes in serum KL-6 levels, yearly decline in FVC (ΔFVC), and the rate of decline (%ΔFVC)...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012487/factors-associated-with-the-relapse-of-cryptogenic-and-secondary-organizing-pneumonia
#15
Yasutaka Onishi, Tetsuji Kawamura, Yasuharu Nakahara, Ryogo Kagami, Shin Sasaki, Sayaka Takahashi, Ryota Kominami, Katsuya Hirano, Ryota Hiraoka, Nobuya Hirata
BACKGROUND: Organizing pneumonia (OP) is a histopathological response pattern to lung inflammation. It is clinically classified into cryptogenic OP and secondary OP, which is associated with various clinical conditions. Rapid resolution with corticosteroids and frequent relapses are common in OP. However, few studies have investigated the factors associated with OP relapse. METHODS: The medical records of 75 patients with biopsy-proven OP, diagnosed between January 2010 and August 2015, who underwent corticosteroid therapy were retrospectively reviewed...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012486/safety-management-of-treatment-with-nintedanib-in-clinical-practice-of-ipf
#16
EDITORIAL
Arata Azuma
No abstract text is available yet for this article.
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/27886865/two-cases-of-pseudo-achalasia-with-lung-cancer-case-report-and-short-literature-review
#17
Taizou Hirano, Eisaku Miyauchi, Akira Inoue, Ryotaro Igusa, Shigeki Chiba, Kazuhiro Sakamoto, Hisatoshi Sugiura, Toshiaki Kikuchi, Masakazu Ichinose
Pseudo-achalasia with lung cancer is a rare complication. We present 2 cases of pseudo-achalasia with lung cancer and summarize previous reports. The previous reports suggested that lung cancer can be complicated with pseudo-achalasia caused by paraneoplastic neurological syndromes rather than direct invasion of the tumor cells to the lower esophageal sphincter, irrespective of the histology of the lung cancer; this can strongly influence the performance status. Treatment for pseudo-achalasia improves not only the symptoms, but also the performance status...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27886864/an-autopsy-case-of-refractory-pulmonary-hypertension-with-sarcoidosis
#18
Hiroki Ota, Keishi Sugino, Toshimasa Uekusa, Tamiko Takemura, Sakae Homma
A 63-year-old man with sarcoidosis-associated pulmonary hypertension (SAPH) died suddenly of decompensated right heart failure. At autopsy, microscopy showed subpleural and interlobular fibrosis in both upper lobes, with marked broncho-bronchiolectasis, as well as bronchovascular bundle fibrosis and fibrotic organization in alveolar lumens, which are consistent with pulmonary sarcoidosis. Intimal fibrosis and medial hypertrophy were noted in the proximal elastic to distal muscular pulmonary arteries (Heath-Edwards, grades II-III) within intensive fibrotic lesions...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27886863/analysis-of-scrub-typhus-involvement-of-the-lung-by-bronchoalveolar-lavage-a-case-report
#19
Shih-Yuan Lin, Yosuke Matsuno, Masahiro Yokosawa, Takeshi Suzuki, Yuko Morishima, Tohru Sakamoto, Takayuki Sumida, Nobuyuki Hizawa
No abstract text is available yet for this article.
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27886862/advancing-tuberculosis-screening-in-japan-historical-considerations-and-the-way-forward
#20
Seiya Kato, Toru Mori
No abstract text is available yet for this article.
November 2016: Respiratory Investigation
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