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Translational Andrology and Urology

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https://www.readbyqxmd.com/read/28217463/prostate-cancer-and-hypofractionation-reflections-on-recent-randomised-phase-iii-clinical-trial-results
#1
COMMENT
David Dearnaley, Emma Hall
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217462/the-therapeutic-potential-of-hif-2-antagonism-in-renal-cell-carcinoma
#2
COMMENT
Olivier Cuvillier
Hypoxia, the insufficient delivery of oxygen for the demand of a tissue, contributes to the development of an aggressive phenotype, resistance to radiation therapy and chemotherapy, and is predictive of a poor outcome in numerous tumor types. Adaptation to hypoxia is mediated by hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, which regulate genes promoting angiogenesis, increased tumor growth or metastasis. In kidney cancer, HIF-2α is believed to be the most important driver for development and progression of clear cell renal cell carcinoma (ccRCC), highlighting the therapeutic potential of HIF-2 antagonists in this disease...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217461/expanding-thermal-ablation-to-the-intermediate-sized-renal-mass-clinical-utility-in-t1b-tumors
#3
EDITORIAL
Ariel A Schulman, Kae Jack Tay, Thomas J Polascik
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217460/collagenase-clostridium-histolyticum-intralesional-injections-for-the-treatment-of-peyronie-s-disease-a-safety-profile
#4
EDITORIAL
Sylvia Yan, Tet Yap, Suks Minhas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217459/complications-and-other-concerns-with-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#5
EDITORIAL
Laurence A Levine
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217458/results-of-smsna-survey-regarding-complications-following-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#6
EDITORIAL
Ates Kadioglu, Emre Salabas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217457/expanding-the-role-of-injectable-collagenase-clostridium-histolyticum-for-the-treatment-of-active-phase-peyronie-s-disease
#7
COMMENT
Louis A Aliperti, Akanksha Mehta
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217456/re-results-of-smsna-survey-regarding-complications-following-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#8
COMMENT
Barbara Kahn, Nelson Bennett
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217455/neoplastic-diseases-of-the-spermatic-cord-an-overview-of-pathological-features-evaluation-and-management
#9
REVIEW
Gautam Dagur, Jason Gandhi, Kailash Kapadia, Rafid Inam, Noel L Smith, Gargi Joshi, Sardar Ali Khan
Extracellular tumors found with the spermatic cord, known as neoplasms, are usually identified to be benign. However, the accurate and timely diagnosis of spermatic cord masses is highly crucial, especially when most results are often overlooked or unclear. In this review, we discuss the anatomy and embryology of the spermatic cord. Upon rooting these fundamental concepts, we discuss an array of benign and malignant neoplastic tumors, including their origin, pathological features, clinical evaluation and management, as well as other case-specific characteristics of unique presentation...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217454/erectile-dysfunction-treatment-and-traditional-medicine-can-east-and-west-medicine-coexist
#10
REVIEW
Joe K C Lee, Ronny B W Tan, Eric Chung
Erectile dysfunction (ED) is a common sexual problem affecting many men irrespective of cultures, beliefs and nationalities. While medical therapy for ED has been revolutionized by the advent of oral phosphodiesterase type 5 inhibitors and intracavernosal injection of vasoactive agents, recent technological advances such stem cell therapy, low intensity shock wave and newer generation of penile prosthesis implant offer hope to men who do not respond to conventional medical therapy. In contrast, traditional and complementary medicine (TCM) focuses on the restoration and better overall bodily regulation with the use of various herbal and animal products as well as exercises to invigorate qi (energy) in vital organs...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217453/erectile-dysfunction-in-fit-and-healthy-young-men-psychological-or-pathological
#11
REVIEW
Giulia Rastrelli, Mario Maggi
Epidemiological studies consistently show that prevalence of erectile dysfunction (ED) increases with ageing. Nonetheless, complaints of ED even in younger men are becoming more and more frequent. Healthcare professionals working in Sexual Medicine but even those operating in different clinical contexts might be adequately prepared to answer this increasing requirement. ED in younger men is likely to be overlooked and dismissed without performing any medical assessment, even the most basic ones, such as collection of medical history and physical exam...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217452/a-review-of-penile-elongation-surgery
#12
REVIEW
Jeffrey Campbell, Joshua Gillis
Penile elongation surgery is less commonly performed in the public sector, but involves a collaborative approach between urology and plastic surgery. Congenital and acquired micropenis are the classic surgical indications for penile elongation surgery. The goal of intervention in these patients is to restore a functional penis size in order to allow normal standing micturition, enable satisfying sexual intercourse and improve patient quality of life. Many men seeking elongation actually have normal length penises, but perceive themselves to be small, a psychologic condition termed 'penile dysmorphophobia'...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217451/erectile-dysfunction-masculinity-and-psychosocial-outcomes-a-review-of-the-experiences-of-men-after-prostate-cancer-treatment
#13
REVIEW
Suzanne K Chambers, Eric Chung, Gary Wittert, Melissa K Hyde
Prostate cancer (PC) treatment side-effects such as erectile dysfunction (ED) can impact men's quality of life (QoL), psychosocial and psycho-sexual adjustment. Masculinity (i.e., men's identity or sense of themselves as being a man) may also be linked to how men respond to PC treatment and ED however the exact nature of this link is unclear. This review aims to provide a snapshot of the current state of evidence regarding ED, masculinity and psychosocial impacts after PC treatment. Three databases (Medline/PsycINFO, CINHAL, and EMBASE) were searched January 1st 1980 to January 31st 2016...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217450/understanding-the-cellular-basis-and-pathophysiology-of-peyronie-s-disease-to-optimize-treatment-for-erectile-dysfunction
#14
REVIEW
Jeffrey Campbell, Raidh Alzubaidi
Erectile dysfunction (ED) is a common condition that significantly impacts a man's physical and psychological well-being. ED is often associated with Peyronie's disease (PD), which is an abnormal curvature of the penis. Delayed treatment of or surgical invention for PD often results in ED and therefore unsatisfied patients. The pathophysiology of PD is incompletely understood, but has been studied extensively and based on our current understanding of PD physiology, many medical treatment options have been proposed...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217449/penile-prosthesis-implant-scientific-advances-and-technological-innovations-over-the-last-four-decades
#15
REVIEW
Eric Chung
Despite introduction of oral phosphodiesterase type 5 inhibitors and intracavernosal vasoactive agents, penile prosthesis implant remains a relevant and desired option with sales of penile prostheses continue to stay high, as many men became refractory to medical therapy and/or seeking a more effective and permanent therapy. There are two types of penile prosthesis implants: inflatable and non-inflatable types, and the inflatable penile implants can be subdivided into single-, two- and three-piece devices. Non-inflatable penile prosthesis (non-IPP) may be referred to as semi-rigid rod or malleable prosthesis...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217448/erectile-dysfunction-metabolic-syndrome-and-cardiovascular-risks-facts-and-controversies
#16
REVIEW
Edward Sanchez, Alexander W Pastuszak, Mohit Khera
Erectile dysfunction (ED) is the most common male sexual dysfunction, and shares many risk factors with systemic conditions including cardiovascular disease (CVD) and the metabolic syndrome (MetS). ED is considered to be an independent risk factor for CVD and can be a harbinger of future cardiovascular events. Given this relationship, each encounter for ED should be viewed by healthcare providers as an opportunity to screen for CVD and other comorbid conditions, including the MetS, that can significantly affect a man's overall health...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217447/aging-related-erectile-dysfunction-potential-mechanism-to-halt-or-delay-its-onset
#17
REVIEW
Monica G Ferrini, Nestor F Gonzalez-Cadavid, Jacob Rajfer
Erectile dysfunction (ED) will visit every man at some time in his life. The age at when that knock on the door is heard is totally dependent on one's genetics as well as other extrinsic factors. Unlike guests who come for a visit and then leave, once ED shows up it tends to hang around forever. To add insult to injury, the longer ED hangs around, the worse it will get. It is estimated that by the time a man is in his 40's, he has about a 40% chance of having some form of ED and this prevalence increases about 10% per decade thereafter...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217446/the-dangers-of-sexual-enhancement-supplements-and-counterfeit-drugs-to-treat-erectile-dysfunction
#18
REVIEW
Jason Chiang, Faysal A Yafi, Philip J Dorsey, Wayne J G Hellstrom
Counterfeit phosphodiesterase-5 inhibitors (PDE-5i) are an increasing problem. Already in widespread use, the market for PDE-5i is steadily growing as the population ages. Counterfeiters are taking advantage of this growing market by developing illicit and counterfeit PDE-5i products. Many factors are contributing to the rapid growth of the illicit market, such as the low risk of prosecution, potentially high financial reward, and ease of distribution via Internet pharmacies. Consumers of illicit PDE-5i often do not realize they are using counterfeit products and placing themselves at an unnecessary health risk...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217445/the-controversy-surrounding-penile-rehabilitation-after-radical-prostatectomy
#19
REVIEW
Jonathan Clavell-Hernández, Run Wang
Radical prostatectomy (RP) techniques have been refined in the last few decades. Despite nerve-sparing surgery, erectile dysfunction (ED) still seems to be affecting more than half of patients undergoing RP. Penile rehabilitation consists of understanding the mechanisms that affect erectile function (EF) and utilizing pharmacologic agents, devices or interventions to promote male sexual function before and after any insult to the penile erectile physiologic axis. There currently is a limited amount of clinical trials that assess treatments with the goal of recovering post-prostatectomy EF...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217444/scientific-advances-and-evidence-based-management-in-erectile-dysfunction
#20
Gerald Brock, Eric Chung
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
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