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Case Reports in Oncological Medicine

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https://www.readbyqxmd.com/read/28083152/giant-anterior-chest-wall-basal-cell-carcinoma-an-approach-to-palliative-reconstruction
#1
Pauline Joy F Santos, Christina Prendergast, Amber Leis
Anterior chest wall giant basal cell carcinoma (GBCC) is a rare skin malignancy that requires a multidisciplinary treatment approach. This case report demonstrates the challenges of anterior chest wall GBCC reconstruction for the purpose of palliative therapy in a 72-year-old female. Surgical resection of the lesion included the manubrium and upper four ribs. The defect was closed with bilateral pectoral advancement flaps, FlexHD, and pedicled VRAM. The palliative nature of this case made hybrid reconstruction more appropriate than rigid sternal reconstruction...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27999696/a-novel-case-of-penile-gangrene-in-a-patient-treated-with-ibrutinib-for-chronic-lymphocytic-leukemia
#2
William Paul Skelton Iv, Neeka N Akhavan, Zachary A Taylor, Thu-Cuc Nguyen, Hassan Hassan, Tabitha N Townsend, Prajwol Pathak, Gaurav Trikha, Nam H Dang, Long H Dang, Azka Ali
Introduction. Ibrutinib is commonly used for the treatment of patients with CLL in either first-line or relapsed/refractory settings. Case Presentation. We present the case of a 74-year-old Caucasian man with CLL who presented with penile gangrene upon initiation of ibrutinib treatment. Our case is the first showing the complication of penile gangrene associated with ibrutinib use. The gangrene was self-limited upon discontinuing ibrutinib. Conclusion. Our finding describes a very rare yet important adverse event associated with ibrutinib use...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27994899/low-grade-lymphoma-mimicking-metastatic-urothelial-carcinoma-when-do-we-need-further-histologic-staging
#3
Azka Ali, William P Skelton Iv, Neeka N Akhavan, Thu-Cuc Nguyen, Zachary A Taylor, Tabitha Townsend, Prajwol Pathak, Nalini Hasija, Li Li, Jacqueline Indrisek, Scott Watson, Isis Nixon, Nam H Dang, Robert Zlotecki, Paul Crispen, Robert Allan, Patricia Abbitt, Long H Dang
Introduction. Patients with urothelial carcinoma of the bladder often present with metastases to regional lymph nodes, with lymphadenopathy on physical examination or radiographic imaging. Case Presentation. We present the case of a 73-year-old Caucasian man with presumed metastatic urothelial carcinoma of the bladder to regional pelvic and retroperitoneal lymph nodes. He underwent systemic chemotherapy for treatment of urothelial carcinoma and was discovered on restaging to have findings suggestive of disease progression but ultimately was found to have a concurrent secondary malignancy...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27994898/recurrence-of-solid-pseudopapillary-tumor-a-rare-pancreatic-tumor
#4
Chandra Punch, Nupur Garg, Penelope Harris
Solid pseudopapillary tumor of the pancreas (SPTP) is a rare disease of young females that does not usually recur after resection. Here we report a case of an elderly female with history of SPTP ten years ago who presented with anorexia and a palpable left lower quadrant abdominal mass. Imaging revealed metastatic disease and US-guided biopsy of the liver confirmed the diagnosis of SPTP. Due to her advanced age and comorbidities, she elected to undergo hospice care. The objective of this case report is to increase awareness of this tumor and its possibility of recurrence, necessitating further guidelines for follow-up...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27990306/primary-pericardial-sarcoma-with-right-atrial-invasion-and-multiple-bilateral-pulmonary-metastases-in-a-patient-with-hereditary-nonpolyposis-colorectal-cancer
#5
Eugene Wong, Lawrence J Oh, Kazi Nahar, Adrian Lee, Stephen Clarke
Primary tumours originating from the pericardium are extremely rare. Previous studies have reported that these tumours account for only 6.7-12.8% of all mediastinal tumours with an overall prevalence of 0.001% to 0.007%. The majority of these tumours are benign lipomas or pericardial cysts. The most common pericardial malignancy is mesothelioma. Sarcomas are soft-tissue mesenchymal malignancies originating from various parts of the body but are extremely rare in this area. We report a case of a 52-year-old female who was diagnosed with a primary sarcoma with rhabdoid differentiation originating from the pericardium...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27957365/corrigendum-to-diagnosis-and-treatment-of-mucinous-appendiceal-neoplasm-presented-as-acute-appendicitis
#6
Ioannis Kehagias, Apollon Zygomalas, Georgios Markopoulos, Thanasis Papandreou, Pantelis Kraniotis
[This corrects the article DOI: 10.1155/2016/2161952.].
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27885349/chronic-lymphocytic-leukemia-with-translocation-2-14-p16-q32-a-case-report-and-review-of-the-literature
#7
Francisco Socola, Giovanni Insuasti-Beltran, Rodolfo Henrich Lobo, Shebli Atrash, Appalanaidu Sasapu
We report the case of a young African American male with no significant past medical history presenting with low back and bilateral leg pain; presenting CBC and chemistries revealed elevated white blood cell count of 250,000, with anemia (Hb 6.8 g/dL) and thrombocytopenia (platelets 9 K/μL), and elevated LDH, 1008. Physical examination findings were notable for diffuse lymphadenopathy and lower extremity skin nodules. Interestingly the bone marrow biopsy revealed involvement by CLL/SLL with translocation (2;14)(p16;q32) and trisomy 12...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27882257/a-hormonally-active-malignant-struma-ovarii
#8
Carolina Lara, Dalia Cuenca, Latife Salame, Rafael Padilla-Longoria, Moisés Mercado
Struma ovarii is a rare monodermal variant of ovarian teratoma that contains at least 50% thyroid tissue. Less than 8% of struma ovarii cases present with clinical and biochemical evidence of thyrotoxicosis due to ectopic production of thyroid hormone and only 5% undergo malignant transformation into a papillary thyroid carcinoma. Only isolated cases of hormonally active papillary thyroid carcinoma developing within a struma ovarii have been reported in the literature. We report the case of a 36-year-old woman who presented with clinical signs and symptoms of hyperthyroidism as well as a left adnexal mass, which proved to be a thyroid hormone-producing, malignant struma ovarii...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27867672/primary-angiosarcoma-of-the-spleen-rare-diagnosis-with-atypical-clinical-course
#9
Filip Kohutek, Ladislav Badik, Branislav Bystricky
Primary angiosarcoma of the spleen is a rare diagnosis with poor prognosis. Morphologically, it demonstrates conventional blood vessel differentiation. We present a case of 65-year-old female who underwent radical splenectomy for primary angiosarcoma of the spleen. After three-year disease-free interval, she was diagnosed with bone-only metastatic disease. Palliative radiotherapy and bisphosphonates kept her disease reasonably stable for another four years. After development of lung metastases, six cycles of single agent doxorubicin kept her progression-free for six years...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27847663/extramedullary-plasmacytoma-mimicking-pancreatic-cancer-an-unusual-presentation
#10
Daniela Sciancalepore, Sergio Musci, Maria Rosaria Fracella, Grazia D'Alesio, Azzurra Sportelli, Giuseppe Ingravallo, Angelo Vacca, Roberto Ria
Multiple myeloma is a plasma cell tumor that homes to and expands in the bone marrow and that, despite the new available drugs, remains incurable. Extramedullary plasmacytoma is a not frequent manifestation during the natural history of multiple myeloma and is frequently associated with plasma cell bone marrow infiltration. The most common locations for an EMP include the gastrointestinal tract, pleura, testis, skin, peritoneum, liver, endocrine glands, and lymph nodes. Primary involvement of the gallbladder fossa is exceedingly rare...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27847662/effectiveness-of-clavicula-pro-humero-reconstruction-for-elderly-patients-report-of-two-cases
#11
Sho Okimatsu, Hiroto Kamoda, Tsukasa Yonemoto, Shintaro Iwata, Takeshi Ishii
Clavicula pro humero (CPH) reconstruction is a method that is used after proximal humeral excision. During CPH reconstruction, the ipsilateral clavicle is rotated downward and connected to the preserved distal humerus by using plates and screws. This method is frequently used for reconstruction surgeries involving young patients and has positive outcomes. In this study, we describe two cases of CPH reconstruction that were performed on elderly individuals after wide resection of the proximal humerus; postoperative results from these surgeries were satisfactory...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27830100/scrotal-involvement-with-testicular-nonseminomatous-germ-cell-tumour
#12
C G O'Leary, J A Allen, F O'Brien, A Tuthill, D G Power
A 37-year-old male presented with a traumatic injury to the scrotal region necessitating emergency surgery. Evacuation of a haematoma and bilateral orchidectomy were performed. A left sided nonseminomatous germ cell tumour (NSGCT), predominantly yolk sac, was identified. Microscopic margins were positive for tumour. Initial tumour markers revealed an AFP of 22,854 ng/mL, HCG of <1 mIU/mL, and LDH of 463 IU/L. Eight weeks after surgery, AFP levels remained elevated at 11,646 ng/mL. Computed tomography (CT) scanning demonstrated left inguinal adenopathy, 1...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27818816/scrotal-apocrine-adenocarcinoma-with-pagetoid-phenomenon-and-inguinal-lymph-node-metastases
#13
Aristeidis Hristos Zibis, Apostolos Haralampos Fyllos, Sophia Havaki, Sotirios Sotiriou, Georgios Kotakidis, Dimitrios Leonidas Arvanitis
We report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as a reddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrine adenocarcinoma with pagetoid phenomenon. The tumor recurred after four months and then excision biopsy showed tumor with pagetoid phenomenon which reached all the surgical margins. Three months later an ulcerated nodule in the scrotum and greatly enlarged ipsilateral inguinal lymph nodes were noticed...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27807492/novel-brentuximab-vedotin-combination-therapies-show-promising-activity-in-highly-refractory-cd30-non-hodgkin-lymphoma-a-case-series-and-review-of-the-literature
#14
Wilfred Delacruz, Robert Setlik, Arash Hassantoufighi, Shyam Daya, Susannah Cooper, Dale Selby, Alexander Brown
Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of hematologic malignancies which typically respond to standard first-line chemoimmunotherapy regimens. Unfortunately, patients with refractory NHL face a poor prognosis and represent an unmet need for improved therapeutics. We present two cases of refractory CD30+ NHL who responded to novel brentuximab vedotin- (BV-) based regimens. The first is a patient with stage IV anaplastic large cell lymphoma (ALCL) with cranial nerve involvement who failed front-line treatment with cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP) and second line cyclophosphamide, vincristine, doxorubicin, dexamethasone alternating with high-dose methotrexate (MTX), and cytarabine (hyperCVAD) with intrathecal- (IT-) MTX and IT-cytarabine, but responded when BV was substituted for vincristine (hyperCBAD)...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27781130/single-jejunum-metastasis-from-breast-cancer-arising-twelve-years-after-the-initial-treatment
#15
Cláudia Paiva, José Garcia, Cristina Silva, Alexandra Araújo, António Araújo, Marisa D Santos
Metastatic involvement of gastrointestinal tract from breast cancer is a rare event. We report the case of a 61-year-old woman presenting with bowel obstruction, related to metastasis of a primary breast cancer she had 12 years earlier (a triple-negative invasive ductal carcinoma treated with surgery and chemotherapy). Bowel obstruction was caused by a 20-centimeter tumor in the jejunum, involving also the transverse colon. The patient underwent en bloc resection of tumor with jejunum and transverse bowel segment and received adjuvant chemotherapy with carboplatin and paclitaxel...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27774327/poor-outcomes-in-hepatic-amyloidosis-a-report-of-2-cases
#16
Brandon Yim, Elizabeth Kertowidjojo, Yue Zhang, Pruthvi Patel
Hepatic amyloidosis is a rare disease entity that results from insoluble amyloid protein deposition in the liver. The disease often presents with vague, nonspecific clinical features. Currently, there is little literature describing treatment outcomes for biopsy-proven hepatic amyloidosis and current treatment guidelines recommend that patients enroll in a clinical trial due to insufficient evidence to suggest an optimal treatment regimen. Here, we present two cases of hepatic amyloidosis at an academic medical center and describe their presentation, treatment, and outcomes...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27752376/refractory-igd-multiple-myeloma-treated-with-daratumumab-a-case-report-and-literature-review
#17
Muhammad Husnain, Sandra Kurtin, Nikki Barkett, Irbaz Bin Riaz, Amit Agarwal
Patients with relapsed and refractory multiple myeloma have poor prognosis. A recent analysis of patients with relapsed and refractory multiple myeloma who were refractory to both proteasome inhibitors and immunomodulatory drugs showed the median overall survival of 9 months only. Daratumumab is the first-in-class human monoclonal antibody against CD38 cells which was studied in phase I/II trials for treatment of these patients with relapsed refractory multiple myeloma. It showed an overall response rate of 36% and a median overall survival (OS) of 17 months in these patients...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27747117/smooth-muscle-tumor-originating-in-the-pleura-a-case-report-and-updated-literature-review
#18
Santiago Fabián Moscoso Martínez, Vadim Zarubin, Geethapriya Rajasekaran Rathnakumar, Alireza Zarineh
Smooth muscle tumors (SMTs) of the pleura are exceptionally rare. At present and to the best of these authors' knowledge, there are only 17 cases reported in the literature. We describe a case of a 51-year-old woman who complained of left sided pleuritic chest pain. Further, computed tomography (CT) revealed a left sided localized pleural-based mass involving the 9th rib. She underwent an interventional radiology guided percutaneous core biopsy of the lesion, which disclosed a "Smooth Muscle Tumor of Undetermined Malignant Potential (SMT-UMP)...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27688920/chemotherapy-used-to-halt-lower-gi-bleeding-in-a-rare-case-of-metastatic-choriocarcinoma-to-the-gi-tract
#19
Ralph Kamel, Talal Seoud, Teniola Oluwadamilola, Michael Karass, Emily Grossniklaus, Gabriela Oprea-Ilies, Daniel A Goldstein, Sanjay Jain
Choriocarcinoma, a nonseminomatous germ cell tumor, is a rare type of testicular malignancy that tends to occur in young males. It is, however, exceedingly rare for choriocarcinoma to involve the GI tract. In this article, we present a rare case of a 31-year-old male, diagnosed with choriocarcinoma of the left testes, along with several metastases to distant sites. The patient presented with headaches and severe lower GI bleeding due to metastases to the GI tract, which was eventually controlled with systemic chemotherapy, while requiring several units of packed RBCs during his admission to the hospital...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27642531/cardiac-relapse-of-acute-myeloid-leukemia-after-allogeneic-hematopoietic-stem-cell-transplantation
#20
María Facenda-Lorenzo, Ana Sánchez-Quintana, Alejandro Quijada-Fumero, Ana Laynez-Carnicero, Joaquín Breña-Atienza, Francisco J Poncela-Mireles, Juan M Llanos-Gómez, Ana I Cabello-Rodríguez, María Ramos-López
Secondary or metastatic cardiac tumors are much more common than primary benign or malignant cardiac tumors. Any tumor can cause myocardial or pericardial metastasis, although isolated or combined tumor invasion of the pericardium is more common. Types of neoplasia with the highest rates of cardiac or pericardial involvement are melanoma, lung cancer, and breast and mediastinal carcinomas. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Initial treatment involves chemotherapy followed by consolidation treatment to reduce the risk of relapse...
2016: Case Reports in Oncological Medicine
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