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Case Reports in Oncological Medicine

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https://www.readbyqxmd.com/read/29780652/cardiac-tamponade-as-the-initial-presentation-of-acute-myeloid-leukemia-a-case-report-with-review-of-the-literature
#1
Dillon Karmo, Adam Hafeez, Alexandra Halalau, Siddhartha Yadav
Acute myeloid leukemia (AML) is a complex disease with a variety of presentations. A large pericardial effusion is rare, occurring in less than 0.5% of all patients with AML prior to treatment. A 34-year-old male presented with dyspnea, malaise, and weight loss. On physical exam, he was noted to be hypoxic, tachypneic, tachycardic, and hypotensive. He had cervical lymphadenopathy and jugular venous distention. His WBC count was 110 bil/L with 33% blasts. Bone marrow biopsy confirmed AML with 60% blasts. Leukemic cells were also seen in the cerebrospinal fluid on lumbar puncture...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29780651/fatal-outcome-of-imatinib-in-a-patient-with-idiopathic-hypereosinophilic-syndrome
#2
Ashraf Abugroun, Ahmed Chaudhary, Gabriel Rodriguez
Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like presentation have made it even more challenging to diagnose, and so far, no well-established treatment protocol has been proposed. Its association with certain medications, especially with monoclonal antibodies, has well been reported in literature...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29780650/metastatic-prostate-cancer-manifesting-as-cholestatic-jaundice-a-case-report-and-review-of-the-literature
#3
Deepak Ravindranathan, Emilie Elise Hitron, Greta Anne Russler, Yue Xue, Mehmet Asim Bilen
A paraneoplastic syndrome can often present as the first manifestation of an underlying malignancy. We report a patient who presented with cholestatic jaundice as a paraneoplastic syndrome from his newly diagnosed metastatic prostate cancer. He received initial treatment with androgen deprivation therapy followed by six cycles of docetaxel resulting in resolution of his cholestatic process, normalization of liver enzyme levels, and excellent biochemical and radiographic response. To the best of our knowledge, this is the first reported case of metastatic prostate cancer with cholestatic jaundice as a paraneoplastic phenomenon to be safely treated with androgen deprivation therapy and upfront docetaxel, reflecting the latest shift in the treatment of metastatic prostate cancer...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29755802/cytomegalovirus-colitis-masquerading-as-apple-core-lesion-after-systemic-chemotherapy-in-a-patient-with-relapsed-acute-myeloid-leukemia
#4
Jong An, Jason Brownell, Darrell Barker, Theresa Stockinger, Robert Brady, Katherine Cebe, Russell Baur
We report the case of a 71-year-old male with relapsed acute myeloid leukemia who developed cytomegalovirus (CMV) colitis presenting as an apple-core lesion during induction chemotherapy. CMV infection occurs rarely during induction chemotherapy for acute myeloid leukemia. CMV infection is usually observed in patients with acquired immune deficiency syndrome (AIDS) and in those on immunosuppressive agents following bone marrow transplant. Although rare, CMV colitis should be considered in patients who are critically ill after systemic chemotherapy as it can cause significant morbidity and mortality...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29744229/alk-positive-squamous-cell-carcinoma-dramatically-responded-to-alectinib
#5
Ray Sagawa, Takehiko Ohba, Eisaku Ito, Susumu Isogai
Anaplastic lymphoma kinase (ALK) rearrangement is usually observed in patients with adenocarcinoma. Herein, we report a case of squamous cell carcinoma (SCC) with ALK rearrangement treated with alectinib. The patient was a 73-year-old woman without a smoking history. She consulted us with nonproductive cough and loss of appetite. Computed tomography scan revealed a mass in the left lower lobe of the lung. According to the pathological examinations, we diagnosed the tumor as SCC. Because the patient had never smoked, we searched for driver mutations and found that the tumor harbored ALK rearrangement...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29736285/nonsmall-cell-lung-carcinoma-with-giant-cell-features-expressing-programmed-death-ligand-1-a-report-of-a-patient-successfully-treated-with-pembrolizumab
#6
Shingo Nakayama, Mamoru Sasaki, Shojiroh Morinaga, Naoto Minematsu
Giant cell carcinoma, a rare variant of nonsmall cell lung carcinoma (NSCLC), is characterized by aggressive progression and poor response to conventional chemotherapy. This report is the first to describe a patient with NSCLC and giant cell features who was successfully treated with pembrolizumab, an antibody targeting programmed death-1 (PD-1). A 69-year-old woman was diagnosed with NSCLC with multiple brain metastases. Histological evaluation of lung biopsy specimens revealed proliferation of pleomorphic giant tumor cells with poor cohesiveness, findings consistent with giant cell carcinoma...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29707398/severe-bilateral-breast-mucinous-carcinoma-with-bilateral-lungs-and-cutaneous-metastasis-a-case-report-and-literature-review
#7
Rong Pu, Yanchu Li, Xianyong Li
The case of a female who had severe, rare, terminal breast mucinous carcinoma (BMC) and failed to receive surgery and chemotherapy was reported. The patient was diagnosed with pure BMC (ER++, PR++, CerbB-2-, and Ki-67 10%) accompanied with bilateral lungs, bilateral chest walls with skin ulcer ( D  = 14 cm), lymph nodes of bilateral armpits, and right supraclavicular metastases. ECOG (Eastern Cooperative Oncology Group) and NRS (Numeric Rating Scale) pain scores were 4 and 6, respectively. Because the patient refused traditional chemotherapy and radiotherapy on religious grounds, an herbal medicine containing Panax ginseng , Agrimonia pilosa , and white flower Patrinia herb was administered; extensive nursing for tumor debridement was also provided...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29707397/safe-administration-of-ipilimumab-pembrolizumab-and-nivolumab-in-a-patient-with-metastatic-melanoma-psoriasis-and-a-previous-guillain-barr%C3%A3-syndrome
#8
Alessio Cortellini, Alessandro Parisi, Maria Concetta Fargnoli, Katia Cannita, Azzurra Irelli, Giampiero Porzio, Claudio Martinazzo, Corrado Ficorella
Background: Patients with autoimmune diseases were not evaluated in clinical trials with immune checkpoint inhibitors (ICIs), since a history of immune disorders, such as Guillain-Barré syndrome (GBS) and psoriasis, is one of the major risk factors for the development of immune-related adverse events (irAEs). This risk cannot be defined; therefore, physicians are called to manage these patients in clinical practice. Case Report: We report the case of a 62-year-old male patient affected by metastatic melanoma, with a history of GBS and psoriasis, and treated with sequential ipilimumab, pembrolizumab, and nivolumab, without significant toxicities...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29707396/orbital-desmoid-type-fibromatosis-a-case-report-and-literature-review
#9
Alessandro Moro, Paolo De Angelis, Giulio Gasparini, Sandro Pelo, Gianluigi Petrone, Emanuela Lucci Cordisco, Umberto Garagiola, Giuseppe D'Amato, Gianmarco Saponaro
Purpose: Desmoid-type fibromatosis is a benign fibrous neoplasia originating from connective tissue, fascial planes, and musculoaponeurotic structures of the muscles. Currently, there is no evidence-based treatment approach available for desmoid fibromatosis. In this article, a case of a patient in the pediatric age affected by desmoid fibromatosis localized in the orbit is presented. The aim of the article is to describe this unusual and rare location for the desmoid fibromatosis and outline the principle phases in the decision-making process and the therapeutic alternatives for a patient affected by desmoid fibromatosis...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29686913/oral-capecitabine-achieves-response-in-metastatic-eccrine-carcinoma
#10
Kristian Larson, Hani M Babiker, Andrew Kovoor, Joy Liau, Jordan Eldersveld, Emad Elquza
The low prevalence rate and limited literature on eccrine carcinoma (EC) pose a challenge to properly diagnosing and treating this rare malignancy. EC lesions tend to present similarly to other cutaneous neoplasms and dermatitis-like conditions. Efficacious treatment guidelines have not been established for patients diagnosed with EC, and few treatment regimens have demonstrated clinical benefit. Due to the high metastatic potential of EC, recognizing the clinical presentation, properly diagnosing, and utilizing beneficial treatment options are important for managing this disease...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29683150/erratum-to-gastric-and-rectal-metastases-from-malignant-melanoma-presenting-with-hypochromic-anemia-and-treated-with-immunotherapy
#11
Pietro Genova, Maria Sorce, Daniela Cabibi, Gaspare Genova, Vittorio Gebbia, Daniele Galanti, Chiara Ancona, Mara Rosaria Valerio
[This corrects the article DOI: 10.1155/2017/2079068.].
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29682376/a-case-of-spontaneously-improving-secondary-hemophagocytic-lymphohistiocytosis-in-an-adult-associated-with-t-cell-histiocyte-rich-large-b-cell-lymphoma
#12
Cyrus Askin, Ashley Burris, Clifton Layman, Brian Haney, Jordan Hall
Secondary hemophagocytic lymphohistiocytosis (HLH) in adults is a rare, often fatal syndrome characterized by widespread immune dysregulation. It is seen as a complication of infections, autoimmune diseases, and malignancies. Among the malignancy-related causes, aggressive T-cell or NK-cell neoplasms are most notable, while B-cell lymphomas are less commonly implicated. We present the case of a 32-year-old male transferred to our facility with concern for HLH. During the first week of his hospitalization, his diagnosis was confirmed and the patient demonstrated spontaneous improvement in his symptoms prompting us to delay therapy while searching for a primary cause...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29682375/myeloid-sarcoma-after-allogenic-stem-cell-transplantation-for-acute-myeloid-leukemia-successful-consolidation-treatment-approaches-in-two-patients
#13
Silje Johansen, Hilde Kollsete Gjelberg, Aymen Bushra Ahmed, Øystein Bruserud, Håkon Reikvam
Myeloid sarcoma is an extramedullary (EM) manifestation (i.e., manifestation outside the bone marrow) of acute myeloid leukemia (AML); it is assumed to be relatively uncommon and can be the only manifestation of leukemia relapse after allogenic stem cell transplantation (allo-SCT). An EM sarcoma can manifest in any part of the body, although preferentially manifesting in immunological sanctuary sites as a single or multiple tumors. The development of myeloid sarcoma after allo-SCT is associated with certain cytogenetic abnormalities, developing of graft versus host disease (GVHD), and treatment with donor lymphocytes infusion (DLI)...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29670788/mature-cystic-teratoma-hiding-in-the-retroperitoneum-of-an-adult
#14
Yardesh Singh, Shamir O Cawich, Thivy Kuruvilla, Sidiyq Mohammed, Ammiel Arra
We report a rare case of a mature cystic teratoma found in the retroperitoneum of a 28-year-old woman with vague symptomatology. We review the radiologic and pathologic features of this rare lesion.
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29670787/radiation-recall-dermatitis-in-patients-treated-with-sorafenib
#15
Keyur Mehta, Andreas Kaubisch, Justin Tang, Aneesh Pirlamarla, Shalom Kalnicki
Introduction: Radiation recall dermatitis (RRD) is a phenomenon that occurs in previously irradiated areas shortly after administration of a chemotherapeutic agent. As the use of sorafenib expands, the incidence of radiation recall dermatitis induced by sorafenib will likely increase. Here, we report on a patient who developed RRD and describe his clinical characteristics along with a review of the literature. Case Presentation: Our patient was treated with palliative radiation therapy (RT) to a painful metastatic hepatocellular carcinoma lesion in the right forearm...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29666732/renal-tubular-acidosis-an-adverse-effect-of-pd-1-inhibitor-immunotherapy
#16
Sandy El Bitar, Chanudi Weerasinghe, Elie El-Charabaty, Marcel Odaimi
Immune checkpoint blockade therapy is gaining popularity among oncologists for treatment of solid and hematologic malignancies. The widespread use of these agents resulted in increasing incidence of renal immune-related adverse events. Reported renal toxicity described so far includes acute interstitial nephritis, minimal change disease, and immune complex glomerulonephritis. We report the case of a 79-year-old female with metastatic non-small cell lung cancer on anti-PD-1 therapy nivolumab. After the 4th administration of nivolumab, the treatment course was complicated with normal anion gap metabolic acidosis...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29623227/fulminant-diabetes-in-a-patient-with-advanced-melanoma-on-nivolumab
#17
Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe
Background: Anti-PD-1 agents were approved for advanced melanoma after the landmark trial Checkmate-037. Anti-PD-1 agents can breach immunologic tolerance. Fulminant diabetes is an immune endocrinopathy that results from a violent immune attack leading to complete destruction of pancreatic beta cells in genetically predisposed people. We present a rare case of fulminant diabetes precipitated by anti-PD-1 immunotherapy. Case: A 61-year-old male with advanced melanoma presented with a three-day history of nausea, vomiting, and malaise...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29607237/adjuvant-radiochemotherapy-with-a-23-month-overall-survival-time-in-a-patient-after-a-surgery-due-to-splenic-hemangiosarcoma-rupture-a-case-report-with-the-literature-review
#18
M Bilski, D Surdyka, I Paśnik, M Bilska, P Cisek, P Korona, J Szumiło, L Grzybowska-Szatkowska
Spleen sarcoma is one of the most rare soft tissue malignancies. The annual incidence is 0.14-0.25/1,000,000 and the average age of diagnosis is 50 to 73 years. The incidence of this cancer has been increasing. Treatment of choice is surgical splenectomy, which rarely gives good results due to the aggressive course of the disease as well as the high potential for metastasis. Overall survival in primary spleen sarcomas as described by various authors is between 4 and 14 months. 80% of patients after spleen rupture do not survive 6 months...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29593922/nivolumab-induced-encephalitis-in-hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome
#19
Benjamin Chaucer, Abriella Stone, Augustus Demanes, Shawn M Seibert
The treatment of cancer is a rapidly evolving field. As more chemotherapeutic agents become available, reporting the side effects of these agents in clinical practice becomes increasingly important. Nivolumab is one of the chemotherapeutic agents commonly used for treatment of renal cell carcinoma, metastatic melanoma, and metastatic non-small cell lung cancer. While common side effects are known and well documented, encephalitis is documented as an extremely rare side effect. We present the case of an extremely rare side effect to a common chemotherapeutic agent...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29552367/a-case-of-chemotherapy-refractory-thrlbcl-like-transformation-of-nlphl-successfully-treated-with-lenalidomide
#20
Mamatha Siricilla, Lydia Irwin, Andres Ferber
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of nonclassical Hodgkin lymphoma (HL). It resembles non-Hodgkin lymphoma (NHL), by expressing classic B cell markers such as CD20 and CD79a however lacks definitive HL markers (such as CD15 and CD30). T cell histiocyte-rich large B cell lymphoma (THRLBCL), on the other hand, is a distinct entity classified under NHL and considered a variant of diffuse large B cell lymphoma (DLBCL). NLPHL can look morphologically and immunologically similar to THRLBCL and often poses a diagnostic challenge...
2018: Case Reports in Oncological Medicine
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