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FEBS Open Bio

Luigi Donato, Placido Bramanti, Concetta Scimone, Carmela Rinaldi, Francesco Giorgianni, Sarka Beranova-Giorgianni, Diwa Koirala, Rosalia D'Angelo, Antonina Sidoti
[This corrects the article DOI: 10.1002/2211-5463.12360.].
November 2018: FEBS Open Bio
(no author information available yet)
[This corrects the article DOI: 10.1002/2211-5463.12436.].
November 2018: FEBS Open Bio
Huan Zhao, Xuan Zhang, Zhifeng Han, Yanjun Wang
It has been reported that p16 protein is overexpressed in many types of solid cancer and its aberrant expression may trigger the immune response, leading to the secretion of anti-p16 antibodies. Here, we developed an in-house ELISA with three p16-derived linear peptide antigens to examine plasma anti-p16 antibody levels in patients with non-small cell lung cancer (NSCLC). Blood samples were taken from 200 control subjects and 211 patients with NSCLC prior to anticancer therapy. A Mann-Whitney U test demonstrated that plasma anti-p16a IgG levels were significantly higher in NSCLC patients than in control subjects ( Z  =   -11...
November 2018: FEBS Open Bio
Ji-Hee Kim, Hanul Kim, Kyu-Hee Hwang, Jae Seung Chang, Kyu-Sang Park, Seung-Kuy Cha, In Deok Kong
With-no-lysine 1 (WNK1) kinase is a substrate of the insulin receptor/Akt pathway. Impaired insulin signaling in skeletal muscle disturbs glucose transporter 4 (GLUT4) translocation associated with the onset of type 2 diabetes (T2D). WNK1 is highly expressed in skeletal muscle. However, it is currently unknown how insulin signaling targeting WNK1 regulates GLUT4 trafficking in skeletal muscle, and whether this regulation is perturbed in T2D. Hereby, we show that insulin phosphorylates WNK1 at its activating site via a phosphatidylinositol 3-kinase-dependent mechanism...
November 2018: FEBS Open Bio
Zongping Li, Hongyuan Liu, Qi Zhong, Jian Wu, Zhi Tang
The 5-year survival rate of patients with glioma is < 5%, and therefore there is an urgent need to find novel potential targets for facilitating its diagnosis and treatment. The long non-coding RNA (lncRNA) UCA1 has been shown to promote the proliferation and invasion of cervical cancer cells through regulating miR-206 expression, but the involvement of UCA1 in regulating the stemness and epithelial-mesenchymal transition (EMT) of glioma cells is unknown. Here, we report that the expression of UCA1 is significantly increased by transforming growth factor-β (TGF-β) treatment in glioma cells and is greater in glioma tissues than in normal adjacent tissues...
November 2018: FEBS Open Bio
Tawin Iempridee, Suphachai Wiwithaphon, Kitiya Piboonprai, Pornpitra Pratedrat, Phattharachanok Khumkhrong, Deanpen Japrung, Sasithon Temisak, Somsak Laiwejpithaya, Pattama Chaopotong, Tararaj Dharakul
Circulating lncRNAs have attracted considerable attention as potential noninvasive biomarkers for diagnosing cancers. RT-qPCR is the canonical technique for detecting circulating RNA and depends largely on stable reference genes for data normalization. However, no systematic evaluation of reference genes for serum lncRNA has been reported for cervical cancer. Here, we profiled and validated lncRNA expression from serum of cervical cancer patients and controls using microarrays and RT-qPCR. We identified lncRNA RP11-204K16...
November 2018: FEBS Open Bio
Alexandra Bernadotte, Rajnish Kumar, Bengt Winblad, Pavel F Pavlov
Dicarboxylate clamp tetratricopeptide repeat (dcTPR) motif-containing proteins are well-known partners of the heat shock protein (Hsp) 70 and Hsp90 molecular chaperones. Together, they facilitate a variety of intracellular processes, including protein folding and maturation, protein targeting, and protein degradation. An extreme C-terminal sequence, the EEVD motif, is identical in Hsp70 and Hsp90, and is indispensable for their interaction with dcTPR proteins. However, almost no information is available on the existence of other potential dcTPR-interacting proteins...
November 2018: FEBS Open Bio
Xing Xu, Ling Duan, Jingwen Yu, Chenggang Su, Jinhua Li, Dan Chen, Xingguo Zhang, Hongyuan Song, Yu Pan
Members of the metallothionein (MT) superfamily are involved in coordinating transition metal ions. In plants, MT family members are characterized by their arrangement of Cys residues. In this study, one member of the MT superfamily, CsMTL3 , was characterized from a complementary DNA (cDNA) library from young cucumber fruit; CsMTL3 is predicted to encode a 64 amino acid protein with a predicted molecular mass of 6.751 kDa. Phylogenetic analysis identified it as a type 3 family member as the arrangement of N-terminal Cys residues was different from that of MT-like 2...
November 2018: FEBS Open Bio
Kazuyo Kamitori, Fuminori Yamaguchi, Youyi Dong, Akram Hossain, Ayako Katagi, Chisato Noguchi, Yuko Hirata, Ikuko Tsukamoto, Naoya Hatano, Masaaki Tokuda
Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down-regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the hepatocellular carcinoma cell line HuH-7. TXNIP contains putative phosphorylation sites, but the effects of its phosphorylation have not been fully characterized. TXNIP also contains two α-arrestin domains (N-arrestin and C-arrestin) whose functions are not fully understood. Here, we reveal an association between TXNIP and cell cycle regulatory proteins (p27kip1 , Jun activation domain-binding protein 1 (JAB1), Cdk2, and cyclin E), suggesting its participation in cell cycle regulation...
November 2018: FEBS Open Bio
Jingmiao Yang, Shaojie Luo, Junhui Li, Zhe Zheng, Xiaodong Du, Yuewen Deng
Heterosis improves growth and survival of shellfish species. Although breeders have widely exploited heterosis, its underlying molecular mechanisms remain unclear. In this study, a 2 × 2 complete diallel cross was facilitated between two full-sib families to produce two inbred families (A and D) and their reciprocal hybrid families (B and C) of pearl oyster Pinctada fucata martensii . Growth traits of the four families were compared at the adult stages. Transcriptome analysis was conducted on the four families using an Illumina sequencing platform...
November 2018: FEBS Open Bio
Kenichiro Takeda, Honami Sawazaki, Haruya Takahashi, Yu-Sheng Yeh, Huei-Fen Jheng, Wataru Nomura, Takeshi Ara, Nobuyuki Takahashi, Shigeto Seno, Naoki Osato, Hideo Matsuda, Teruo Kawada, Tsuyoshi Goto
To clarify the effects of a dipeptidyl peptidase-4 (DPP-4) inhibitor on whole-body energy metabolism, we treated mice fed a high-fat diet (HFD) with teneligliptin, a clinically available DPP-4 inhibitor. Teneligliptin significantly prevented HFD-induced obesity and obesity-associated metabolic disorders. It also increased oxygen consumption rate and upregulated uncoupling protein 1 (UCP1) expression in both brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT), suggesting that it enhances BAT function...
November 2018: FEBS Open Bio
Xiyong Fan, Chris McLaughlin, Jason Ravasini, Cleo Robinson, Anthony M George
For centuries, zeolites have been used for their utility in binding metals, and they feature in a multitude of agricultural and industrial applications in which the honeycombed zeolite structures form ideal ion exchangers, catalysts and binding agents. Zeolites are currently in a transition period, moving towards implementation in human ailments and diseases. Here, we postulated that zeolites may be able to counter the effects of excess iron and conducted a mouse model trial to gauge the utility of this notion...
November 2018: FEBS Open Bio
Petra Molnár, Lívia Marton, Richard Izrael, Hajnalka L Pálinkás, Beáta G Vértessy
Plasmodium falciparum parasites undergo multiple genome duplication events during their development. Within the intraerythrocytic stages, parasites encounter an oxidative environment and DNA synthesis necessarily proceeds under these circumstances. In addition to these conditions, the extreme AT bias of the P. falciparum genome poses further constraints for DNA synthesis. Taken together, these circumstances may allow appearance of damaged bases in the Plasmodium DNA. Here, we focus on uracil that may arise in DNA either via oxidative deamination or thymine-replacing incorporation...
November 2018: FEBS Open Bio
Aishwarya Narayan, Pragati Mastud, Vandana Thakur, Pradipsinh K Rathod, Asif Mohmmed, Swati Patankar
Glutathione peroxidase-like thioredoxin peroxidase (PfTPxGl ) is an antioxidant enzyme trafficked to the apicoplast, a secondary endosymbiotic organelle, in Plasmodium falciparum . Apicoplast trafficking signals usually consist of N-terminal signal and transit peptides, but the trafficking signal of PfTPxGl appears to exhibit important differences. As transfection is a protracted process in P. falciparum , we expressed the N terminus of PfTPxGl as a GFP fusion protein in a related apicomplexan, Toxoplasma gondii , in order to dissect its trafficking signals...
November 2018: FEBS Open Bio
Chiharu Moriya, Kohzoh Imai, Hiroaki Taniguchi
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer that is typically diagnosed at a later stage with metastases and is difficult to treat. Therefore, investigating the mechanism of PDAC initiation is important to aid early-stage cancer detection. PRDM14 is a transcription factor that maintains pluripotency in embryonic stem cells and is overexpressed in several cancers. We previously reported that PRDM14 is overexpressed and regulates cancer stem-like phenotypes in PDAC, and herein, we assess whether PRDM14 expression increases prior to tumorigenesis...
October 2018: FEBS Open Bio
Zunqiang Yan, Tiantuan Jiang, Pengfei Wang, Xiaoyu Huang, Qiaoli Yang, Wenyang Sun, Shuangbao Gun
Clostridium perfringens type C is a pathogen that causes necrotizing enteritis (NE), which is an intestinal tract disease in piglets. The pathogenesis of C. perfringens type C-induced NE is still unclear, leading to a lack of effective therapies. Earlier studies have reported that circular RNAs (circRNAs) are involved in the pathogenic processes of various diseases. However, it is not known if circRNAs in spleen play a role in C. perfringens type C infection in NE. To address this question, we infected 7-day-old piglets with C...
October 2018: FEBS Open Bio
Wei Zhu, Lanfen Li, Mingjing Deng, Bo Wang, Mengfei Li, Guofang Ding, Zuisu Yang, Dan Medynski, Xiaotao Lin, Ying Ouyang, Jirui Lin, Luyuan Li, Xinli Lin
Native α1-antitrypsin (AAT) is a 52-kDa glycoprotein that acts as an antiprotease and is the physiological inhibitor of neutrophil serine proteases. The main function of AAT is to protect the lung from proteolytic damage induced by inflammation. AAT deficiency (AATD) is a codominant autosomal disorder caused by pathogenic mutations in SERPINA1 gene, leading to reduced levels of serum AAT. The deficiency is known to increase the risk of pulmonary emphysema and chronic obstructive pulmonary disease as a consequence of proteolytic imbalance induced by inflammation, associated in many instances with cigarette smoking and other environmental hazards...
October 2018: FEBS Open Bio
Xian-Yang Qin, Jun Lu, Muyi Cai, Soichi Kojima
We previously reported a profound augmentation in the hepatic levels of a pro-inflammatory precursor, arachidonic acid (AA), during liver tumorigenesis. Here, we report a critical role of the induced reactive oxygen species (ROS)-mediated cellular activation of a protein cross-linking enzyme, transglutaminase 2 (TG2), in liver injury by AA. In cultures of hepatic cells, AA dose-dependently suppressed cell growth, which accompanied the induced nuclear accumulation of TG2, as demonstrated in EGFP-tagged, TG2-overexpressing hepatic cells...
October 2018: FEBS Open Bio
Keisuke Tanaka, Naoko Teramura, Osamu Hayashida, Katsumasa Iijima, Teru Okitsu, Shunji Hattori
The collagenase secreted by Grimontia hollisae strain 1706B is a 74 kDa protein that consists of two parts: the catalytic module and a C-terminal segment that includes the bacterial pre-peptidase C-terminal domain. Here, we produced a recombinant C-terminal segment protein and examined its ability to bind collagen and other characteristics as compared with collagen-binding domains (CBDs) derived from Hathewaya histolytica ( Clostridium histolyticum ) collagenases; these CBDs are the only ones thus far identified in bacterial collagenases...
October 2018: FEBS Open Bio
Prajna Tripathi, Priyanka Parijat, Virendra Kumar Patel, Janendra K Batra
Mycobacterium tuberculosis ( Mtb ) is known to persist in extremely hostile environments within host macrophages. The ability to withstand such proteotoxic stress comes from its highly conserved molecular chaperone machinery. ClpB, a unique member of the AAA+ family of chaperones, is responsible for resolving aggregates in Mtb and many other bacterial pathogens. Mtb produces two isoforms of ClpB, a full length and an N-terminally truncated form (ClpB∆N), with the latter arising from an internal translation initiation site...
October 2018: FEBS Open Bio
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