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International Journal of Pharmaceutical Investigation

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https://www.readbyqxmd.com/read/29184828/radioprotective-effect-of-hesperidin-on-reducing-oxidative-stress-in-the-lens-tissue-of-rats
#1
Navid Karimi, Ali Shabestani Monfared, Gholam Hassan Haddadi, Abbas Soleymani, Erfan Mohammadi, Karimollah Hajian-Tilaki, Sajad Borzoueisileh
Introduction: Oxidative stress is a common factor in cataract. Considering the antioxidant properties of hesperidin as a flavanone glycoside from the flavonoid family with radioprotective effect, this study aimed to determine the protective effect of this flavanone glycoside on reducing oxidative stress in the eye lens tissue of mature rats caused by gamma irradiation. Materials and Methods: A total of 48 adult rats were randomly divided into six groups, namely, control, Dimethyl sulfoxide (DMSO), hesperidin, radiation, radiation + DMSO, and radiation + hesperidin...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29184827/development-of-a-binary-carrier-system-consisting-polyethylene-glycol-4000-ethyl-cellulose-for-ibuprofen-solid-dispersion
#2
Gada Sulaiman A Alagdar, May Kyaw Oo, Pinaki Sengupta, Uttam Kumar Mandal, Julian Md Jaffri, Bappaditya Chatterjee
Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aimed to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29184826/isolation-and-identification-of-probiotic-lactobacillus-from-local-dairy-and-evaluating-their-antagonistic-effect-on-pathogens
#3
Sahar Karami, Mohammad Roayaei, Hosna Hamzavi, Mahmoud Bahmani, Hassan Hassanzad-Azar, Mahmoodnia Leila, Mahmoud Rafieian-Kopaei
Objective: Probiotics such as lactobacilli prevent the development of a wide range of human and animal's pathogens. The aim of this study was evaluation of antagonistic effect of isolated lactobacilli from local dairy products against three standard strains of Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Materials and Methods: Twenty samples of local dairy products including cow milk, buffalo milk, cheese, and yogurt were collected from different areas of Ahwaz city...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29184825/a-comparative-evaluation-of-diclofenac-sodium-transdermal-patch-oral-diclofenac-sodium-with-intramuscular-injections-of-diclofenac-sodium-in-patients-suffering-from-oral-pain-a-randomized-control-trial
#4
Nallan Csk Chaitanya, P Karunakar, Komali Garlapati, Mounika Yeladandi, Pallavi Bidari, Pratima Soni
Background: Newer drug delivery systems such as transdermal patches using pain relieving or modifying agents emerged as a mainstream treatment protocol for management of pain on the outpatient basis. The administration of diclofenac 100 mg in the transdermal patch in the patients having dental pain due to periapical/periodontal infections was evaluated. Materials and Methods: Ninety patients of either gender, between 18 and 80 years were divided into 3 groups (Group A - oral medication, Group B - transdermal patch, Group C - intramuscular group)...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29184824/smartphone-usage-and-increased-risk-of-mobile-phone-addiction-a-concurrent-study
#5
Subramani Parasuraman, Aaseer Thamby Sam, Stephanie Wong Kah Yee, Bobby Lau Chik Chuon, Lee Yu Ren
Objective: This study aimed to study the mobile phone addiction behavior and awareness on electromagnetic radiation (EMR) among a sample of Malaysian population. Methods: This online study was conducted between December 2015 and 2016. The study instrument comprised eight segments, namely, informed consent form, demographic details, habituation, mobile phone fact and EMR details, mobile phone awareness education, psychomotor (anxious behavior) analysis, and health issues...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29184823/a-prospective-randomized-controlled-study-theophylline-on-oxidative-stress-and-steroid-sensitivity-in-chronic-obstructive-pulmonary-disease-patients
#6
R Ranjani, A T Sathiya Vinotha
Objective: Oxidative stress is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Corticosteroid fails to suppress inflammation and oxidative stress due to steroid resistance. Theophylline has an effect on histone deacetylase (HDAC) activity and improves steroid sensitivity in COPD. Given changes in oxidative stress associated with diminished corticosteroid effects, a clinical study in which antioxidants and free radicals are estimated can suggest a correlation between antioxidants, theophylline, and corticosteroid sensitivity...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29184822/gingivitis-and-plaque-prevention-using-three-commercially-available-dentifrices-a-comparative-clinical-and-microbiological-randomized-control-parallel-study
#7
Ramprasad Reddy, Rajababu Palaparthy, Satyanarayana Durvasula, Pradeep Koppolu, Essam Elkhatat, Khaled Ali Rajab Assiri, A Al Sulaiman Abdulrahman Saad
Aim: The aim of the study was to compare the clinical and microbiological efficacy of Group I-delmopinol dentifrice, Group II-chlorhexidine, and Group III-triclosan-containing regularly used control dentifrice on plaque formation and gingivitis. Materials and Methods: A total of 45 healthy volunteer students fulfilling the inclusion criteria are recruited for this randomized control parallel study. All the individuals were randomly assigned into 3 groups depending on the dentifrice prescribed...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929054/prosthetic-rehabilitation-of-a-geriatric-patient-with-squamous-cell-carcinoma-of-the-buccal-mucosa-a-report-of-clinical-challenges
#8
Raghavendra Adaki, Sarvesh Raikar, Kamal Shigli, Sivaranjani Gali
OBJECTIVE: This article aims to highlight the rehabilitation of a geriatric patient with an orofacial cheek defect by an extraoral silicone prosthesis. METHODOLOGY: Structured extra- and intra-oral examination of tissues coupled with a justified choice of impression materials, techniques, and prosthetic rehabilitation with a high-temperature vulcanizing silicone was done. RESULTS: The presence of compressible tissues, static appearance of the prosthesis during patient's facial movements, variability in complexion of the skin around the defect, and manipulating heat-vulcanized silicone were the challenges faced during clinical procedures...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929053/thermoreversible-in-situ-gel-for-subgingival-delivery-of-simvastatin-for-treatment-of-periodontal-disease
#9
Swaminathan Rajendran, K Sathesh Kumar, S Ramesh, Suresh Ranga Rao
OBJECTIVE: The aim of this in vitro study was to formulate an in situ thermoreversible injectable gel with poloxamer (PM) and methylcellulose (MC) to deliver simvastatin (SMV) in a controlled manner. SUBJECTS AND METHODS: Preformulation studies (Fourier transform infrared and differential scanning calorimetry) to assess the interaction between SMV and MC and PM were performed before gel formulation. Keeping the concentration of SMV at 2.2%, the concentration of PM and MC was altered to formulate in situ thermosensitive gel at 37°C...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929052/simultaneous-determination-of-rutin-isoquercetin-and-quercetin-flavonoids-in-nelumbo-nucifera-by-high-performance-liquid-chromatography-method
#10
P Naveen, H B Lingaraju, Anitha, K Shyam Prasad
OBJECTIVE: The present study was investigated to provide a documentary evidence for the determination of rutin, isoquercetin, and quercetin flavonoids from the flora of Nelumbo nucifera by reversed-phase high-performance liquid chromatography (RP-HPLC). MATERIALS AND METHODS: RP-HPLC analysis was performed by gradient elution with a low-pressure gradient using 0.5% acetic acid: acetonitrile as a mobile phase with a flow rate of 1.0 ml/min. The separation was done at 26°C using a Kinetex XB-C18 column as stationary phase and the detection wavelength at 356 nm...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929051/comparison-of-effectiveness-of-calendula-officinalis-extract-gel-with-lycopene-gel-for-treatment-of-tobacco-induced-homogeneous-leukoplakia-a-randomized-clinical-trial
#11
Manisha Singh, Anjana Bagewadi
AIM: The aim of the study is to assess the efficacy of Calendula officinalis gel as cost-effective treatment modality in comparison to lycopene gel in the treatment of leukoplakia. MATERIALS AND METHODS: The study comprised of sixty patients of clinically diagnosed and histopathologically confirmed cases of homogeneous leukoplakia which were divided into Group I and Group II with thirty patients each. Group I patients were dispensed C. officinalis extract gel whereas Group II patients were given lycopene gel...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929050/synergistic-effect-of-carum-copticum-and-mentha-piperita-essential-oils-with-ciprofloxacin-vancomycin-and-gentamicin-on-gram-negative-and-gram-positive-bacteria
#12
Gholam-Reza Talei, Mohsen Mohammadi, Mahmoud Bahmani, Mahmoud Rafieian Kopaei
BACKGROUND: Infectious diseases have always been an important health issue in human communities. In the recent years, much research has been conducted on antimicrobial effects of nature-based compounds because of increased prevalence of antibiotic resistance. The present study was conducted to investigate synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram-negative and Gram-positive bacteria. MATERIALS AND METHODS: In this experimental study, the synergistic effects of C...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929049/antifungal-effects-of-lactobacillus-species-isolated-from-local-dairy-products
#13
Sahar Karami, Mohammad Roayaei, Elnaz Zahedi, Mahmoud Bahmani, Leila Mahmoodnia, Hosna Hamzavi, Mahmoud Rafieian-Kopaei
OBJECTIVE: The Lactobacillus is a genus of lactic acid bacteria which are regularly rod-shaped, nonspore, Gram-positive, heterogeneous, and are found in a wide range of inhabitants such as dairy products, plants, and gastrointestinal tract. A variety of antimicrobial compounds and molecules such as bacteriocin are produced by these useful bacteria to inhibit the growth of pathogenic microbes in the food products. This paper aims to examine the isolation of Lactobacillus from local dairies as well as to determine their inhibition effect against a number of pathogens, such as two fungi: Penicillium notatum and Aspergillus fulvous...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929048/brand-versus-generic-dispensing-trend-for-ciprofloxacin-500-mg-levofloxacin-500-mg-and-moxifloxacin-400-mg-oral-dosage-forms-among-pharmacies-of-karachi-pakistan
#14
Fatima Zehra, Atta Abbas Naqvi, Sumbul Tasneem, Rizwan Ahmad, Niyaz Ahmad, Adnan Zia Shamsi, Naqiya Ali Asghar, Ghufran Ullah Khan
INTRODUCTION: Pakistan spends 0.7% of its gross domestic product on health. The public sector health-care system provides services to 22% of population thus paving the way for a dominant private sector. Patients in Pakistan mostly pay their medical expenses directly, and 64% of the health expenditures are borne by the household. Expenditure on medicine constitutes 43% of the total household expenditure. METHODS: A quantitative cross-sectional study was conducted in Karachi, Pakistan, for a month...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929047/determining-frequency-of-genes-of-ctx-m-and-ctx-m-15-of-producing-enterobacteriaceae-of-isolated-extended-spectrum-beta-lactamases-from-clinical-samples-of-patients-referred-to-training-hospitals-of-medical-sciences-university-khorramabad-iran
#15
Seyed Mojtaba Mosavian, Azam Rezvani-Rad
OBJECTIVE: The purpose of conducting this research was evaluation of the frequency of extended-spectrum beta-lactamases (ESBLs) in separated Enterobacteriaceae isolates from clinical samples in Khorramabad city and determination of their antimicrobial resistance pattern. MATERIALS AND METHODS: In this study, 240 isolates belonging to Enterobacteriaceae family were collected in time duration between March and June in 2014. The isolates were identified by standard biochemical tests...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929046/application-of-three-dimensional-printing-for-colon-targeted-drug-delivery-systems
#16
REVIEW
Nitin B Charbe, Paul A McCarron, Majella E Lane, Murtaza M Tambuwala
Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide have been interested in colon drug delivery for several decades, not only for the delivery of the drugs for the treatment of colonic diseases such as ulcerative colitis and colon cancer but also for delivery of therapeutic proteins and peptides for systemic absorption...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28929045/compensation-to-clinical-trial-participants-in-india-a-gap-analysis
#17
REVIEW
Mohd Urooj, Gulam Mohammed Husain, Mohammad Ahmed Khan, Munawwar Husain Kazmi
The recent amendments notified by the Government of India, for conducting clinical trial, is greatly appreciable as promoting safety and well-being of human subjects. These rules clearly state that medical management of injuries in clinical trials is mandatory, and clinical trial-related injury or death needs to be compensated over and above the medical management. These rules need to be reconsidered for simplification and better understanding of issues regarding compensation. There is a need of clarity at some points which should be discussed with all stakeholders for better understanding of current regulations...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28405577/a-comprehensive-physicochemical-thermal-and-spectroscopic-characterization-of-zinc-ii-chloride-using-x-ray-diffraction-particle-size-distribution-differential-scanning-calorimetry-thermogravimetric-analysis-differential-thermogravimetric-analysis-ultraviolet
#18
Mahendra Kumar Trivedi, Kalyan Kumar Sethi, Parthasarathi Panda, Snehasis Jana
OBJECTIVE: Zinc chloride is an important inorganic compound used as a source of zinc and has other numerous industrial applications. Unfortunately, it lacks reliable and accurate physicochemical, thermal, and spectral characterization information altogether. Hence, the authors tried to explore in-depth characterization of zinc chloride using the modern analytical technique. MATERIALS AND METHODS: The analysis of zinc chloride was performed using powder X-ray diffraction (PXRD), particle size distribution, differential scanning calorimetry (DSC), thermogravimetric analysis/differential thermogravimetric analysis (TGA/DTG), ultraviolet-visible spectroscopy (UV-vis), and Fourier transform-infrared (FT-IR) analytical techniques...
January 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28405576/evaluation-of-anti-diabetic-activity-of-ahpl-aytab-0513-tablet-in-streptozotocin-induced-diabetes-in-rats
#19
Sanjay U Nipanikar, Soham S Chitlange, Dheeraj Nagore
BACKGROUND: Diabetes is a chronic, progressive disease associated with several complications leading to significant mortality and morbidity. Limitations and drawbacks of the conventional treatment generate need for safer, effective complimentary therapies to prevent complications, and maintain normoglycemic status. AIM AND OBJECTIVES: The aim of this study is to to evaluate antidiabetic activity of AHPL/AYTAB/0513 tablet alone, oral hypoglycemic agents (OHA[s]), and combination of AHPL/AYTAB/0513 tablet and OHA(s) in streptozotocin-induced diabetes in rats...
January 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28405575/factorial-analysis-of-the-binding-properties-of-acetylated-ginger-starch-in-metronidazole-tablet-formulations
#20
Oluyemisi Adebowale Bamiro, Abioye Josephina Duro-Emanuel
INTRODUCTION: The delivery of drug is often affected by formulation processes and the excipients used in the formulation. MATERIALS AND METHODS: A 2(3) factorial analysis was used in this study to evaluate the effect of acetylated ginger starch (AGS) (Zingiber officinale) as a binder in metronidazole tablets, in comparison to corn starch (CS) BP. The individual and interacting effects of variables (binder type X1, binder concentration X2, and compression pressure X3) used on tablet properties such as friability, crushing strength, crushing strength friability ratio (CSFR), disintegration and crushing strength friability/disintegration time ratio (CSFR/DT) were determined...
January 2017: International Journal of Pharmaceutical Investigation
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