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International Journal of Pharmaceutical Investigation

N Arjun, D Narendar, K Sunitha, K Harika, B Nagaraj
PURPOSE: Osmotic devices are the most promising strategy-based systems for controlled drug delivery. By optimizing formulation and processing parameters, possible to develop osmotic systems to deliver drugs at predetermined rate with high in vitro-in vivo correlation. The aim of the present investigation was to develop an oral elementary osmotic pump (EOP) of atenolol with zero-order or near zero-order drug release profile. MATERIALS AND METHODS: Differential scanning calorimetry and Fourier transform-infrared spectroscopy studies did not show any evidence of interaction between the drug and excipients...
October 2016: International Journal of Pharmaceutical Investigation
Jafar Fattahi-Asl, Mojtaba Karbalaee, Masoud Sanatizadeh, Payam Amini
OBJECTIVE: The aim of this study was to compare the effects of radiofrequency radiation (RF) in synergism with gold (Au) and silver (Ag) nanoparticles (NPs) on the survival fraction of human normal kidney (HNK) and human embryonic kidney (HEK) cells. MATERIALS AND METHODS: HNK and HEK cells were divided into three groups as control, 1 and 2 h/day-irradiated groups for 8 days. To compare the effects of RF in the presence of Au-NPs and Ag-NPs, the cells were incubated with NPs during the irradiation...
October 2016: International Journal of Pharmaceutical Investigation
Guo Huimin, Fu Xiaoying, Du Hongwei, Cong Wei, Meng Xiangcai
INTRODUCTION: The quality of radix scutellariae is particularly associated with environmental stresses, but detailed mechanisms remained unclear. Plant under unfavorable situation generates redundant reactive oxygen species (ROS), and ROS can modify the secondary metabolism. The varied quality of radix scutellariae could be explained by ROS. MATERIALS AND METHODS: .004, 0.4, and 40 μmol/L of sodium dithionite (Na2S2O4), a material producing ROS, were applied to Scutellaria baicalensis to mimic unfavorable situation...
October 2016: International Journal of Pharmaceutical Investigation
Naveen Kanthamneni, Satyanarayana Valiveti, Mita Patel, Heather Xia, Yin-Chao Tseng
INTRODUCTION: The majority of drugs obtained through synthesis and development show poor aqueous solubility and dissolution velocity, resulting in reduced bioavailability of drugs. Most of these problems arise from formulation-related performance issues, and an efficient way to overcome these obstacles and to increase dissolution velocity is to reduce the particle size of drug substances to form drug nanosuspensions. MATERIALS AND METHODS: Danazol nanosuspensions were prepared by wet milling (WM) and high-pressure homogenization (HPH) methods...
October 2016: International Journal of Pharmaceutical Investigation
Nilima A Thombre, Ajit V Vishwakarma, Trupti S Jadhav, Sanjay J Kshirsagar
BACKGROUND: To formulation and development of plasma volume expander (PVE) by using natural and modified starch from Solanum tuberosum. The function of blood circulation is to provide the needs of the body tissues and to maintain an appropriate environment in all tissue fluids of the body for the optimal survival and functions of the cells. Rapid restoration of the blood volume is necessary to decrease reduction in the amount of the blood. The PVEs are isotonic colloidal solutions, act by increasing the osmotic pressure of the intravascular compartment, which leads to the influx of the interstitial fluids through the capillary pore which, in turn, leads to the increase in the volume of the blood...
October 2016: International Journal of Pharmaceutical Investigation
Poluri Koteswari, G Puja Sravanthi, M Mounika, S K Mohammed Rafi, K Nirosha
OBJECTIVE: The present investigation involves the development of zolmitriptan oral soluble film (OSF) formulations and optimization with quality by design (QBD) using natural polymers and evaluation. MATERIALS AND METHODS: Initially, various natural polymers such as sodium alginate, pectin, and gelatin were screened by casting films using solvent casting technique and the prepared films were evaluated. Based on the physical and mechanical properties, sodium alginate was selected as best film former and zolmitriptan-loaded films were casted...
October 2016: International Journal of Pharmaceutical Investigation
Krishnamoorthy Venkateskumar, Subramani Parasuraman, Raju Gunasunderi, Krishnan Sureshkumar, M Muralidhar Nayak, Syed Adnan Ali Shah, Khoo Kassen, Heng Wei Kai
OBJECTIVE: The objective of this study is to provide a mechanistic insight into solubility enhancement and dissolution of acyclovir (ACY) by polyethylene glycol20000 (PEG20000). MATERIALS AND METHODS: Solid dispersions with differing ratios of drug (ACY) and carrier (PEG20000) were prepared and evaluated by phase solubility, in vitro release studies, kinetic analysis, in situ perfusion, and in vitro permeation studies. Solid state characterization was also done by Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared spectroscopy (FT-IR) analysis and surface morphology was assessed by Polarizing Microscopic Image (PMI) analysis, Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), and Nuclear Magnetic Resonance (NMR) analysis...
October 2016: International Journal of Pharmaceutical Investigation
Smita Raghuvanshi, Kamla Pathak
INTRODUCTION: The study was aimed at the development of low-density gastroretentive bioadhesive microsponges of cinnarizine by two-pronged approach (i) coating with bioadhesive material and (ii) exploration of acconon MC 8-2 EP/NF as bioadhesive raw material for fabrication. MATERIALS AND METHODS: Microsponges were prepared by quasi-emulsion solvent diffusion method using 3(2) factorial design. Capmul GMO was employed for bioadhesive coating. In parallel, potential of acconon for the fabrication of bioadhesive floating microsponges (A8) was assessed...
October 2016: International Journal of Pharmaceutical Investigation
Govada Kishore Babu, Puttagunta Srinivasa Babu, Mukkanti Khagga
INTRODUCTION: Valsartan is a type II Biopharmaceutics Classification System (BCS) classified drug. The poor aqueous solubility restricts its use in developing sustained or controlled release systems for the treatment of chronic hypertensive conditions. The present investigation was conducted with an objective to formulate porous matrices (PMs) of valsartan in order to enhance aqueous solubility. MATERIALS AND METHODS: Polyvinylpyrrolidone (PVP) K30 and poloxamer 407 were used as hydrophilic carriers; hexane was used as a pore-forming agent, ethanol was used as a solvent, and tween 20 was used as an emulgent...
July 2016: International Journal of Pharmaceutical Investigation
Vaishali Thakkar, Vaishali Korat, Lalji Baldaniya, Mukesh Gohel, Tejal Gandhi, Nirav Patel
INTRODUCTION: The aim of burn management and therapy is fast healing and epithelisation to prevent infection. The present study is concerned with the development and characterization of a novel nanaoparticulate system; cubosomes, loaded with silver sulfadiazine (SSD) and Aloe vera for topical treatment of infected burns. METHODS: Cubosome dispersions were formulated by an emulsification technique using different concentrations of a lipid phase Glyceryl Monooleate (GMO) and Poloxamer 407...
July 2016: International Journal of Pharmaceutical Investigation
Nallaguntla Lavanya, Yallamalli Indira Muzib, Jithan Aukunuru, Umamahesh Balekari
OBJECTIVE: The objective of the present work was to prepare and evaluate a novel oral formulation for systemic delivery of low molecular weight heparin (LMWH). The formulation consisted of Eudragit S 100-coated positively charged liposomes encapsulating LMWH and a penetration enhancer. MATERIALS AND METHODS: Positively charged liposomes were first prepared by the thin film hydration method using lipid (soy phosphotidylcholine and cholesterol) and stearyl amine (SA) in the optimum ratio of 16:1, along with cetylpyridinium chloride (CPC) as a penetration enhancer...
July 2016: International Journal of Pharmaceutical Investigation
Kenneth C Ofokansi, Franklin C Kenechukwu, Richard O Ezugwu, Anthony A Attama
BACKGROUND: The purpose of this study was to develop ibuprofen (IB)-polyethylene glycol (PEG) 8000 solid dispersions (SDs) and investigate them for in vitro dissolution and in vivo anti-inflammatory activity. MATERIALS AND METHODS: IB-PEG 8000 SDs were prepared by fusion method using varying combination ratios of IB and PEG 8000. Characterization based on surface morphology, particle size, absolute drug content, and Fourier transform infrared (FT-IR) spectroscopy was carried out on the SDs...
July 2016: International Journal of Pharmaceutical Investigation
Kannissery Pramod, M Abu Tahir, Naseem A Charoo, Shahid H Ansari, Javed Ali
The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications...
July 2016: International Journal of Pharmaceutical Investigation
Jobin Jose, R Narayana Charyulu
INTRODUCTION: The potent antifungal agent amphotericin B (AmB) is not freely soluble in water. The clinical use of AmB is limited by nephrotoxicity and poor water solubility. Polyamidoamine (PAMAM) dendrimer offers an identical carrier for drug binding that has the capacity to attach and discharge drugs in numerous ways. MATERIALS AND METHODS: In this research work, we explored the potential of PAMAM dendrimers to improve the solubility of AmB. RESULTS AND DISCUSSION: The experimental results indicated that the solubility of AmB was greatly enhanced in the presence of PAMAM dendrimer solutions...
April 2016: International Journal of Pharmaceutical Investigation
Haritha Siddam, Niranjan G Kotla, Balaji Maddiboyina, Sima Singh, Omprakash Sunnapu, Anil Kumar, Dinesh Sharma
INTRODUCTION: Oral sustained release gastro retentive dosage forms offer several advantages for drugs having absorption from the upper gastrointestinal tract to improve the bioavailability of medications which have narrow absorption window. The aim of the study was to develop a floating bioadhesive drug delivery system exhibiting a unique combination of floatation and bioadhesion to prolong the residence in the stomach using atenolol as a model drug. METHODS: Prior to compression, polymeric blend(s) were evaluated for flow properties...
April 2016: International Journal of Pharmaceutical Investigation
Kamla Pathak, Vijay Sharma, Nida Akhtar, Pragya Rastogi
BACKGROUND: The present research work was aimed at localization of fluconazole in the oral cavity by preferential coating of buccoadhesive tablet for the treatment of oral thrush. MATERIALS AND METHODS: In order to achieve the aim, buccoadhesive tablets were optimized using 3(2) full factorial design to study the influence of varying content of chitosan and carbopol 934P (input variables) on the responses. RESULTS: Perturbation plots revealed high sensitivity of the input variables to ex vivo mucoadhesion force and percent cumulative drug release (CDR) whereas the ex vivo mucoadhesion time was less sensitive to the input variables...
April 2016: International Journal of Pharmaceutical Investigation
Tara Abdulrahman Abdullah, Naz Jamal Ibrahim, Musarrat Husain Warsi
INTRODUCTION: Superiority of topical instillation of drug into the cul-de-sac for the treatment of various ophthalmic complications can be validated with commercial availability of a large number of conventional formulations even though this mode of instillation still elicits limitations owing to poor ocular bioavailability. To overcome the drawbacks of conventional formulations, a large number of novel carriers have been investigated. In this perspective, a new novel nanocarrier, chondroitin sulfate (ChS)-chitosan (CS)-nanoparticles (NPs) are being evaluated for improved delivery of bromfenac sodium...
April 2016: International Journal of Pharmaceutical Investigation
Durai Prabu, Amin F Majdalawieh, Imad A Abu-Yousef, Kadambari Inbasekaran, Tharani Balasubramaniam, Narayanan Nallaperumal, Conjeevaram J Gunasekar
INTRODUCTION: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose (HPMC) or hydroxypropyl cellulose (HPC) polymers, as potential wound dressing materials based on their physicochemical properties and the sustain-release phenomenon. MATERIALS AND METHODS: The physicochemical properties of the prepared hydrogel membranes were evaluated by several methods including Fourier transform infrared and differential scanning calorimetry...
April 2016: International Journal of Pharmaceutical Investigation
Elham Khodaverdi, Marzieh Gharechahi, Mona Alibolandi, Farnaz Sadat Mirzazadeh Tekie, Bibi Zahra Khashyarmanesh, Farzin Hadizadeh
In this study, thermosensitive, water-soluble, and biodegradable triblock copolymer PCL600-PEG6000-PCL600 was used to form supramolecular hydrogel (SMGel) by inclusion complexation with γ-cyclodextrin (γ-CD). The prepared SMGel was investigated as a carrier for sustained release of dexamethasone. The triblock copolymer PCL-PEG-PCL [where PCL = polycaprolactone, PEG = poly(ethylene glycol)] was synthesized by the ring-opening polymerization method using microwave irradiation. The polymerization reaction and the copolymer structures were evaluated by nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC)...
April 2016: International Journal of Pharmaceutical Investigation
Franklin C Kenechukwu, Mumuni A Momoh
INTRODUCTION: The aim of this study was to use Eudragit(®) RL 100 (pH-independent polymer) and magnesium stearate (a hydrophobic droplet stabilizer) in combination to improve the controlled release effect of insulin-loaded Eudragit(®) entrapped microspheres prepared by the emulsification-coacervation technique. MATERIALS AND METHODS: Mucoadhesive insulin-loaded microspheres containing magnesium stearate and varying proportions of Eudragit(®) RL 100 were prepared by the emulsification-coacervation technique and evaluated for thermal properties, physicochemical performance, and in vitro dissolution in acidic and subsequently basic media...
April 2016: International Journal of Pharmaceutical Investigation
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