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Systematic Reviews

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https://www.readbyqxmd.com/read/29149908/exosomal-micrornas-as-potential-circulating-biomarkers-in-gastrointestinal-tract-cancers-a-systematic-review-protocol
#1
Elmira Gheytanchi, Zahra Madjd, Leila Janani, Arezoo Rasti, Roya Ghods, Fatemeh Atyabi, Mohammad Hossein Asadi Lari, Sadegh Babashah
BACKGROUND: Metastasis is the most frequent type of recurrence in gastrointestinal (GI) cancers, and there is an emerging potential for new diagnostic and therapeutic approaches, especially in the cases of metastatic GI carcinomas. The expression profiles of circulating exosomal microRNAs are of particular interest as novel non-invasive diagnostic and prognostic biomarkers for improved detection of GI cancers in body fluids, especially in the serum of patients with recurrent cancers. The aim of this study is to systematically review primary studies and identify the miRNA profiles of serum exosomes of GI cancers...
November 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29149907/mapping-evidence-on-the-distribution-of-human-papillomavirus-related-cancers-in-sub-saharan-africa-scoping-review-protocol
#2
Bridget K M Lekoane, Tivani P Mashamba-Thompson, Themba G Ginindza
BACKGROUND: Despite the introduction of HPV vaccines, the incidence of HPV-related cancers (cervical, penile, anal, vulvar, vagina, head, and neck) in sub-Saharan Africa has been rising. The increasing incidence of these HPV-related cancers has been attributed to changes in lifestyle-related risk factors, most notably sexual behavior. The main objective of this study is to map evidence on the distribution of HIV-related cancers in sub-Saharan Africa (SSA). METHODS AND ANALYSIS: We will conduct a scoping review to explore, describe, and map literature on the distribution of HPV-related cancers in sub-Saharan Africa...
November 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29141664/prevalence-and-prognosis-of-acutely-ill-patients-with-organ-failure-at-arrival-to-hospital-protocol-for-a-systematic-review
#3
Peter Bank Pedersen, Asbjorn Hrobjartsson, Daniel Lykke Nielsen, Daniel Pilsgaard Henriksen, Mikkel Brabrand, Annmarie Touborg Lassen
BACKGROUND: Acutely ill patients are a heterogeneous group, and some of these suffer from organ failure. As the prognosis of organ failure improves with early treatment, it is important to identify these patients as early as possible. Most studies on organ failure have been performed in intensive care settings, or on selected groups of patients, where a high prevalence and mortality have been reported. Before patients arrive to the intensive care unit, or the general ward, most of them have passed through the emergency department (ED), where diagnosis and treatment has been initiated...
November 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29116020/assessment-of-safety-and-efficacy-of-mesenchymal-stromal-cell-therapy-in-preclinical-models-of-acute-myocardial-infarction-a-systematic-review-protocol
#4
Carly C Barron, Manoj M Lalu, Duncan J Stewart, Dean Fergusson, Homer Yang, David Moher, Peter Liu, David Mazer, P J Devereaux, Lauralyn McIntyre
BACKGROUND: Despite advances in treatment, acute myocardial infarction (MI) is still associated with significant morbidity and mortality, especially in patients with extensive damage and scar formation. Based on some promising preclinical studies, there is interest in the use of mesenchymal stromal cells (MSCs) to promote cardiac repair after acute MI. However, there is a need for a systematic review of this evidence to summarize the efficacy and safety of MSCs in preclinical models of MI...
November 7, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29100533/effectiveness-of-interventions-during-nicu-hospitalization-on-the-neurodevelopment-of-preterm-infants-a-systematic-review-protocol
#5
Marilyn Aita, Robyn Stremler, Nancy Feeley, Andréane Lavallée, Gwenaëlle De Clifford-Faugère
BACKGROUND: Previous systematic reviews have examined preterm infants' long-term neurodevelopment after neonatal intensive care unit (NICU) discharge, although none have explored the effectiveness of interventions on preterm infants' neurodevelopment during NICU hospitalization. The aim of this review is to evaluate whether interventions, i.e., sensory stimulation, parental involvement, and control of environment, improve preterm infants' neurodevelopment during their NICU hospitalization...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29100499/the-role-of-psychosocial-stress-in-the-development-of-chronic-musculoskeletal-pain-disorders-protocol-for-a-systematic-review-and-meta-analysis
#6
Valentina Buscemi, Wei-Ju Chang, Matthew B Liston, James H McAuley, Siobhan Schabrun
BACKGROUND: Psychosocial factors play an important role in chronic musculoskeletal pain disorders. Although psychosocial stress is likely to contribute to the development of chronic musculoskeletal pain, investigations are limited to work-related stress or examination of specific conditions such as upper limb pain. The purpose of this review is to assess the evidence for an aetiological role of psychological stress in chronic musculoskeletal pain disorders. METHODS: A systematic review and meta-analysis will be conducted...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29100498/reliability-of-measurements-of-the-fractured-clavicle-a-systematic-review
#7
Paul Hoogervorst, Gerjon Hannink, Arnoud R van Geene, Albert van Kampen
BACKGROUND: The objective of this systematic review was to evaluate the reliability and reproducibility of measurements of shortening in midshaft clavicle fractures (MSCF) using any available imaging technique. METHODS: Electronic databases (PubMed, EMBASE, and Cochrane) were searched. The 4-point-scale COSMIN checklist was used to evaluate the methodological quality of studies. RESULTS: Four studies on reliability of measurement of MSCF were identified...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29100497/the-macro-economic-determinants-of-health-and-health-inequalities-umbrella-review-protocol
#8
Yannish Naik, Peter Baker, Ian Walker, Taavi Tillmann, Kristin Bash, Darryl Quantz, Frances Hillier-Brown, Clare Bambra
BACKGROUND: The economic determinants of health have been widely recognised as crucial factors affecting health; however, to date, no comprehensive review has been undertaken to summarise these factors and the ways in which they can influence health. We conceptualise the economy as a complex system made up of underlying approaches, regulation from institutions, markets, finance, labour, the public-private balance as well as production and distributional effects, which collectively impact on health through the effect of moderators...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29096723/mobile-tablet-based-therapies-following-stroke-a-systematic-scoping-review-protocol-of-attempted-interventions-and-the-challenges-encountered
#9
Michael Pugliese, Dylan Johnson, Dar Dowlatshahi, Tim Ramsay
BACKGROUND: Stroke is a growing global epidemic limiting the ability of millions to function independently due to post-stroke deficits and complications. Although specialized stroke rehabilitation improves the recovery of functional abilities, accessing rehabilitation services has become increasingly challenging as the number of stroke survivors continues to increase and rehabilitation resources remain scarce. Mobile tablet-based therapies (MTBTs) may be a resource-efficient platform for providing stroke rehabilitation services...
November 2, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29096721/methodological-quality-and-transparency-of-clinical-practice-guidelines-for-the-pharmacological-treatment-of-non-communicable-diseases-using-the-agree-ii-instrument-a-systematic-review-protocol
#10
Caroline de Godoi Rezende Costa Molino, Eliane Ribeiro, Nicolina Silvana Romano-Lieber, Airton Tetelbom Stein, Daniela Oliveira de Melo
BACKGROUND: Non-communicable diseases (NCDs) are the leading cause of death worldwide. Clinical practice guidelines (CPGs) constitute an important tool for the promotion of evidence-based health, which may improve healthcare outcomes for individuals with NCDs. Studies have shown that many CPGs have poor or moderate quality. Therefore, the aim of the proposed study is to systematically identify and appraise CPGs for pharmacological treatment of the most prevalent NCDs in primary care. METHODS: A comprehensive literature search will be conducted in the following databases: MEDLINE, Embase and Cochrane Library...
November 2, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29096710/putting-research-in-place-an-innovative-approach-to-providing-contextualized-evidence-synthesis-for-decision-makers
#11
Stephen Bornstein, Rochelle Baker, Pablo Navarro, Sarah Mackey, David Speed, Melissa Sullivan
BACKGROUND: The Contextualized Health Research Synthesis Program (CHRSP), developed in 2007 by the Newfoundland and Labrador Centre for Applied Health Research, produces contextualized knowledge syntheses for health-system decision makers. The program provides timely, relevant, and easy-to-understand scientific evidence; optimizes evidence uptake; and, most importantly, attunes research questions and evidence to the specific context in which knowledge users must apply the findings. METHODS: As an integrated knowledge translation (KT) method, CHRSP: Involves intensive partnerships with senior healthcare decision makers who propose priority research topics and participate on research teams; Considers local context both in framing the research question and in reporting the findings; Makes economical use of resources by utilizing a limited number of staff; Uses a combination of external and local experts; and Works quickly by synthesizing high-level systematic review evidence rather than primary studies...
November 2, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29096708/family-resilience-and-adaptive-coping-in-children-with-juvenile-idiopathic-arthritis-protocol-for-a-systematic-review
#12
Sophia Saetes, Lisa Hynes, Brian E McGuire, Line Caes
BACKGROUND: This systematic review is the first step in a study investigating the resilience methods and processes in families of children with juvenile idiopathic arthritis. In particular, this review will focus on chronic or persistent pain, as a common symptom of juvenile idiopathic arthritis, which is the most common rheumatic disease in childhood. The experience of persistent pain can add to the functional disability associated with juvenile idiopathic arthritis. Resilience has relevance to all areas of paediatric psychology, and targeted attention to child, sibling, and parent strengths within the context of paediatric chronic pain and juvenile idiopathic arthritis in particular will augment the field on numerous levels...
November 2, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29070081/understanding-the-experience-of-initiating-community-based-physical-activity-and-social-support-by-people-with-serious-mental-illness-a-systematic-review-using-a-meta-ethnographic-approach
#13
Helen Quirk, Helen Crank, Deborah Harrop, Emma Hock, Robert Copeland
BACKGROUND: People with long-term serious mental illness live with severe and debilitating symptoms that can negatively influence their health and quality of life, leading to outcomes such as premature mortality, morbidity and obesity. An interplay of social, behavioural, biological and psychological factors is likely to contribute to their poor physical health. Participating in regular physical activity could bring symptomatic improvements, weight loss benefits, enhanced wellbeing and when undertaken in a community-based group setting can yield additional, important social support benefits...
October 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29070063/availability-and-performance-of-image-video-based-vital-signs-monitoring-methods-a-systematic-review-protocol
#14
Mirae Harford, Jacqueline Catherall, Stephen Gerry, Duncan Young, Peter Watkinson
BACKGROUND: For many vital signs, monitoring methods require contact with the patient and/or are invasive in nature. There is increasing interest in developing still and video image-guided monitoring methods that are non-contact and non-invasive. We will undertake a systematic review of still and video image-based monitoring methods. METHODS: We will perform searches in multiple databases which include MEDLINE, Embase, CINAHL, Cochrane library, IEEE Xplore and ACM Digital Library...
October 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29070061/effectiveness-of-real-time-polymerase-chain-reaction-assay-for-the-detection-of-mycobacterium-tuberculosis-in-pathological-samples-a-systematic-review-and-meta-analysis
#15
Emmanuel O Babafemi, Benny P Cherian, Lee Banting, Graham A Mills, Kandala Ngianga
BACKGROUND: Rapid and accurate diagnosis of tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Many established diagnostic methods suffer from low sensitivity or delay of timely results and are inadequate for rapid detection of Mycobacterium tuberculosis (MTB) in pulmonary and extra-pulmonary clinical samples. This study examined whether a real-time polymerase chain reaction (RT-PCR) assay, with a turn-a-round time of 2 h, would prove effective for routine detection of MTB by clinical microbiology laboratories...
October 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29070060/the-relationship-between-childhood-body-weight-and-dental-caries-experience-an-umbrella-systematic-review-protocol
#16
Susan J Carson, Lamis Abuhaloob, Derek Richards, Mark P Hector, Ruth Freeman
BACKGROUND: Obesity and dental caries are global public health problems which can impact in childhood and throughout the life course. In simple terms, childhood dental caries and body weight are linked via the common risk factor of diet. An association between dental caries and obesity has been described in a number of studies and reviews. However, similarly, a relationship has also been noted between low body weight and caries experience in children. This protocol will provide the framework for an umbrella review to address the following question: Does the available evidence support a relationship between dental caries experience and body weight in the child population? METHODS: This review protocol outlines the process to carry out an umbrella systematic review which will synthesise previous reviews of childhood dental caries experience and body weight...
October 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29065919/diabetes-related-information-seeking-behaviour-a-systematic-review
#17
Silke Kuske, Tim Schiereck, Sandra Grobosch, Andrea Paduch, Sigrid Droste, Sarah Halbach, Andrea Icks
BACKGROUND: Information-seeking behaviour is necessary to improve knowledge on diabetes therapy and complications. Combined with other self-management skills and autonomous handling of the disease, it is essential for achieving treatment targets. However, a systematic review addressing this topic is lacking. The aims of this systematic review were to identify and analyse existing knowledge of information-seeking behaviour: (1) types information-seeking behaviour, (2) information sources, (3) the content of searched information, and (4) associated variables that may affect information-seeking behaviour...
October 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29065915/interventions-for-acute-stroke-management-in-africa-a-systematic-review-of-the-evidence
#18
Leonard Baatiema, Carina K Y Chan, Adem Sav, Shawn Somerset
BACKGROUND: The past decades have witnessed a rapid evolution of research on evidence-based acute stroke care interventions worldwide. Nonetheless, the evidence-to-practice gap in acute stroke care remains variable with slow and inconsistent uptake in low-middle income countries (LMICs). This review aims to identify and compare evidence-based acute stroke management interventions with alternative care on overall patient mortality and morbidity outcomes, functional independence, and length of hospital stay across Africa...
October 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29065911/effectiveness-of-behavioral-change-techniques-employed-in-ehealth-interventions-designed-to-improve-glycemic-control-in-persons-with-poorly-controlled-type-2-diabetes-a-systematic-review-and-meta-analysis-protocol
#19
Mihiretu Kebede, Lara Christianson, Zohaib Khan, Thomas L Heise, Claudia R Pischke
BACKGROUND: The incorporation of Behavioral Change Techniques (BCTs) in eHealth interventions for the management of non-communicable diseases (NCDs), such as type 2 diabetes mellitus (T2DM), might be a promising approach to improve clinical and behavioral outcomes of NCDs in the long run. This 3paper reports a protocol for a systematic review that aims to (a) identify the effects of individual BCTs in eHealth interventions for lowering glycated hemoglobin levels (HbA1c) and (b) investigate which additional intervention features (duration of intervention, tailoring, theory-base, and mode of delivery) affect levels of HbA1c in this population...
October 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29061188/authors-response-to-comments-from-nachman-ke-et-al
#20
LETTER
Annette M O'Connor, Brent W Auvermann, Rungano S Dzikamunhenga, Julie M Glanville, Julian P T Higgins, Shelley P Kirychuk, Jan M Sargeant, Sarah C Totton, Hannah Wood, Susanna G Von Essen
Authors' response to comments letter to the editor from Nachman KE et al.
October 23, 2017: Systematic Reviews
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