journal
MENU ▼
Read by QxMD icon Read
search

Journal of the American Heart Association

journal
https://www.readbyqxmd.com/read/28325714/warning-about-shortcuts-in-drug-development
#1
EDITORIAL
Robert M Califf
No abstract text is available yet for this article.
March 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28325713/two-decades-of-cardiovascular-trials-with-primary-surrogate-endpoints-1990-2011
#2
Behnood Bikdeli, Natdanai Punnanithinont, Yasir Akram, Ike Lee, Nihar R Desai, Joseph S Ross, Harlan M Krumholz
BACKGROUND: Surrogate endpoint trials test strategies more efficiently but are accompanied by uncertainty about the relationship between changes in surrogate markers and clinical outcomes. METHODS AND RESULTS: We identified cardiovascular trials with primary surrogate endpoints published in the New England Journal of Medicine, Lancet, and JAMA: Journal of the American Medical Association from 1990 to 2011 and determined the trends in publication of surrogate endpoint trials and the success of the trials in meeting their primary endpoints...
March 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320751/sex-and-outcomes-after-percutaneous-coronary-intervention-a-cause-for-concern-for-young-women-and-those-with-st-segment-elevation-myocardial-infarction
#3
EDITORIAL
Jacqueline E Tamis-Holland
No abstract text is available yet for this article.
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320750/metabolic-mediators-of-the-effects-of-family-history-and-genetic-risk-score-on-coronary-heart-disease-findings-from-the-malm%C3%A3-diet-and-cancer-study
#4
Josef Fritz, Dov Shiffman, Olle Melander, Hayato Tada, Hanno Ulmer
BACKGROUND: Family history of coronary heart disease (CHD) as well as genetic predisposition to CHD assessed by a genetic risk score (GRS) are predictors of CHD risk. It is, however, uncertain to what extent these risk predictors are mediated by major metabolic pathways. METHODS AND RESULTS: Total effects of self-reported family history and a 50-variant GRS (GRS50), as well as effects mediated by apolipoprotein B and A-I (apoB, apoA-I), blood pressure, and diabetes mellitus, on incidence of CHD were estimated in 23 595 participants of the Malmö Diet and Cancer study (a prospective, population-based study)...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320749/sex-differences-in-percutaneous-coronary-intervention-insights-from-the-coronary-angiography-and-pci-registry-of-the-german-society-of-cardiology
#5
Tobias Heer, Matthias Hochadel, Karin Schmidt, Julinda Mehilli, Ralf Zahn, Karl-Heinz Kuck, Christian Hamm, Michael Böhm, Georg Ertl, Hans Martin Hoffmeister, Stefan Sack, Jochen Senges, Steffen Massberg, Anselm K Gitt, Uwe Zeymer
BACKGROUND: Several studies have suggested sex-related differences in diagnostic and invasive therapeutic coronary procedures. METHODS AND RESULTS: Data from consecutive patients who were enrolled in the Coronary Angiography and PCI Registry of the German Society of Cardiology were analyzed. We aimed to compare sex-related differences in in-hospital outcomes of patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease, non-ST elevation acute coronary syndromes, ST elevation myocardial infarction, and cardiogenic shock...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320748/association-of-husband-smoking-with-wife-s-hypertension-status-in-over-5%C3%A2-million-chinese-females-aged-20-to-49%C3%A2-years
#6
Ying Yang, Fangchao Liu, Long Wang, Qian Li, Xingyu Wang, Julia C Chen, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Man Zhang, Yuan He, Zuoqi Peng, Yuanyuan Wang, Jihong Xu, Jun Zhao, Ya Zhang, Hongguang Zhang, Xiaona Xin, Yan Wang, Dujia Liu, Tongjun Guo, Qiaoyun Dai, Xu Ma
BACKGROUND: The effect of second-hand smoking, especially husband smoking, on wife's hypertension has not been well studied. The current study was aimed to assess the association of husband smoking with wife's hypertension among females aged 20 to 49 years. METHODS AND RESULTS: This study included 5 027 731 females along with their husbands from the National Free Pre-pregnancy Checkup Projects conducted across 31 provinces in China in 2014. Smoking/passive smoking status was collected by a standard questionnaire and blood pressure was measured by an electronic device after 10 minutes rest...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320747/association-of-cardiovascular-health-with-subclinical-disease-and-incident-events-the-multi-ethnic-study-of-atherosclerosis
#7
Tamar S Polonsky, Hongyan Ning, Martha L Daviglus, Kiang Liu, Gregory L Burke, Mary Cushman, John Eng, Aaron R Folsom, Pamela L Lutsey, Jennifer A Nettleton, Wendy S Post, Ralph L Sacco, Moyses Szklo, Donald M Lloyd-Jones
BACKGROUND: Few adults have ideal cardiovascular health (CVH). We studied associations of an overall CVH score with subclinical cardiovascular disease and events. We assessed whether associations varied by race/ethnicity. METHODS AND RESULTS: Among 5961 participants in the Multi-Ethnic Study of Atherosclerosis, components of CVH were measured at baseline, 2000-2002: systolic blood pressure, total cholesterol, fasting glucose, smoking, physical activity, diet, and body mass index...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320746/race-and-sex-differences-in-qrs-interval-and-associated-outcome-among-patients-with-left-ventricular-systolic-dysfunction
#8
Tiffany C Randolph, Samuel Broderick, Linda K Shaw, Karen Chiswell, Robert J Mentz, Valentina Kutyifa, Eric J Velazquez, Francis R Gilliam, Kevin L Thomas
BACKGROUND: Prolonged QRS duration is associated with increased mortality among heart failure patients, but race or sex differences in QRS duration and associated effect on outcomes are unknown. METHODS AND RESULTS: We investigated QRS duration and morphology among 2463 black and white patients with heart failure and left ventricular ejection fraction ≤35% who underwent coronary angiography and 12-lead electrocardiography at Duke University Hospital from 1995 through 2011...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320745/statin-use-and-the-risk-of-cataracts-a-systematic-review-and-meta-analysis
#9
REVIEW
Shandong Yu, Yanpeng Chu, Gang Li, Lu Ren, Qing Zhang, Lin Wu
BACKGROUND: Cataracts are the main cause of poor vision and blindness worldwide. The effects of statin administration on cataracts remain debated. Therefore, we conducted a systematic review and meta-analysis to determine whether statin use affects the risk of cataracts. METHODS AND RESULTS: We performed a systematic search of the electronic databases PubMed, EMBASE, and the Cochrane Library through January 2016. Weighted averages were reported as relative risk values with 95% CIs...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320744/angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-are-associated-with-improved-outcome-but-do-not-prevent-new-onset-atrial-fibrillation-after-acute-myocardial-infarction
#10
Gorav Batra, Lars Lindhagen, Pontus Andell, David Erlinge, Stefan James, Jonas Spaak, Jonas Oldgren
BACKGROUND: Treatment with renin-angiotensin system (RAS) inhibitors might restrain the structural/electrical remodeling associated with atrial fibrillation (AF). Limited evidence exists regarding the potential benefits of RAS inhibition post-acute myocardial infarction (AMI) in patients with AF. This study sought to assess the association between RAS inhibition and all-cause mortality and new-onset AF in patients with/without congestive heart failure (CHF) post-AMI. METHODS AND RESULTS: Patients hospitalized for AMI between 2006 and 2012 were identified in Swedish registries...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28315826/early-invasive-strategy-and-in-hospital-survival-among-diabetics-with-non-st-elevation-acute-coronary-syndromes-a-contemporary-national-insight
#11
Ahmed N Mahmoud, Islam Y Elgendy, Hend Mansoor, Xuerong Wen, Mohammad K Mojadidi, Anthony A Bavry, R David Anderson
BACKGROUND: There are limited data on the merits of an early invasive strategy in diabetics with non-ST-elevation acute coronary syndrome, with unclear influence of this strategy on survival. The aim of this study was to evaluate the in-hospital survival of diabetics with non-ST-elevation acute coronary syndrome treated with an early invasive strategy compared with an initial conservative strategy. METHODS AND RESULTS: The National Inpatient Sample database, years 2012-2013, was queried for diabetics with a primary diagnosis of non-ST-elevation acute coronary syndrome defined as either non-ST-elevation myocardial infarction or unstable angina (unstable angina)...
March 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314801/characterization-of-foci-and-breakthrough-sites-during-persistent-and-long-standing-persistent-atrial-fibrillation-in-patients-studies-using-high-density-510-512-electrodes-biatrial-epicardial-mapping
#12
Seungyup Lee, Jayakumar Sahadevan, Celeen M Khrestian, Alan Markowitz, Albert L Waldo
BACKGROUND: We previously demonstrated that persistent and long-standing persistent atrial fibrillation is maintained by activation emanating from foci and breakthrough sites of different cycle lengths (CLs). The purpose of this study was to characterize the behavior of focal and nonrandom breakthrough activation identified during high-density mapping of atrial fibrillation in these patients. METHODS AND RESULTS: During open heart surgery, we recorded activation from both atria simultaneously using 510 to 512 epicardial electrodes along with ECG lead II in 12 patients with persistent and long-standing persistent atrial fibrillation...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314800/performance-of-the-atherosclerotic-cardiovascular-disease-pooled-cohort-risk-equations-by-social-deprivation-status
#13
Lisandro D Colantonio, Joshua S Richman, April P Carson, Donald M Lloyd-Jones, George Howard, Luqin Deng, Virginia J Howard, Monika M Safford, Paul Muntner, David C Goff
BACKGROUND: The atherosclerosis cardiovascular disease (ASCVD) Pooled Cohort risk equations have shown different calibration across US populations with varied levels of social deprivation. METHODS AND RESULTS: We analyzed the calibration and discrimination of the Pooled Cohort risk equations by social deprivation status among 9066 REGARDS (REasons for Geographic And Racial Differences in Stroke) study participants not taking statins for whom ASCVD risk may lead to statin initiation...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314799/coronary-atherosclerotic-vulnerable-plaque-current-perspectives
#14
REVIEW
Christodoulos Stefanadis, Christos-Konstantinos Antoniou, Dimitrios Tsiachris, Panagiota Pietri
No abstract text is available yet for this article.
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314798/insulin-like-growth-factor-binding-protein-4-fragments-provide-incremental-prognostic-information-on-cardiovascular-events-in-patients-with-st-segment-elevation-myocardial-infarction
#15
Rikke Hjortebjerg, Søren Lindberg, Sune Pedersen, Rasmus Mogelvang, Jan S Jensen, Claus Oxvig, Jan Frystyk, Mette Bjerre
BACKGROUND: Fragments of insulin-like growth factor binding protein 4 (IGFBP-4) are potential new biomarkers for cardiac risk assessment. The fragments are generated on specific cleavage by pregnancy-associated plasma protein-A, which exerts proatherogenic activity. This study investigated the prognostic value of IGFBP-4 fragments in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS: We prospectively included 656 patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention from September 2006 to December 2008...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314797/effect-of-2013-acc-aha-blood-cholesterol-guidelines-on-statin-treatment-patterns-and-low-density-lipoprotein-cholesterol-in-atherosclerotic-cardiovascular-disease-patients
#16
Ted Okerson, Jeetvan Patel, Stefan DiMario, Tanya Burton, Jerald Seare, David J Harrison
BACKGROUND: Preceding release of the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guidelines, prescribers aimed for specific low-density lipoprotein cholesterol (LDL-C) goals in patients with atherosclerotic cardiovascular disease (ASCVD). The 2013 guidelines changed this focus to treating patients with appropriate statin intensity given their ASCVD risk. We examined statin use and LDL-C levels before and after the 2013 ACC/AHA guidelines in patients with clinical ASCVD as defined in the guidelines...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314796/prehypertensive-blood-pressures-and-regional-cerebral-blood-flow-independently-relate-to-cognitive-performance-in-midlife
#17
J Richard Jennings, Matthew F Muldoon, Christopher Ryan, H Michael Gach, Alicia Heim, Lei K Sheu, Peter J Gianaros
BACKGROUND: High blood pressure is thought to contribute to dementia in late life, but our understanding of the relationship between individual differences in blood pressure (BP) and cognitive functioning is incomplete. In this study, cognitive performance in nonhypertensive midlife adults was examined as a function of resting BP and regional cerebral blood flow (rCBF) responses during cognitive testing. We hypothesized that BP would be negatively related to cognitive performance and that cognitive performance would also be related to rCBF responses within areas related to BP control...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28298373/prognostic-impact-of-in-hospital-and-postdischarge-heart-failure-in-patients-with-acute-myocardial-infarction-a-nationwide-analysis-using-data-from-the-cardiovascular-disease-in-norway-cvdnor-project
#18
Gerhard Sulo, Jannicke Igland, Ottar Nygård, Stein Emil Vollset, Marta Ebbing, Neil Poulter, Grace M Egeland, Charlotte Cerqueira, Torben Jørgensen, Grethe S Tell
BACKGROUND: Heart failure (HF) is a serious complication of acute myocardial infarction (AMI). We explored the excess mortality associated with HF as an early or late complication of AMI and describe changes over time in such excess mortality. METHODS AND RESULTS: All patients hospitalized with an incident AMI and without history of prior HF hospitalization were followed up to 1 year after AMI discharge for episodes of HF. New HF episodes were classified as in-hospital HF if diagnosed during the AMI hospitalization or postdischarge HF if diagnosed within 1 year after discharge from the incident AMI...
March 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28298372/what-is-the-evidence-that-the-tissue-doppler-index-e-e-reflects-left-ventricular-filling-pressure-changes-after-exercise-or-pharmacological-intervention-for-evaluating-diastolic-function-a-systematic-review
#19
REVIEW
Oleg F Sharifov, Himanshu Gupta
BACKGROUND: Noninvasive echocardiographic tissue Doppler assessment (E/e') in response to exercise or pharmacological intervention has been proposed as a useful parameter to assess left ventricular (LV) filling pressure (LVFP) and LV diastolic dysfunction. However, the evidence for it is not well summarized. METHODS AND RESULTS: Clinical studies that evaluated invasive LVFP changes in response to exercise/other interventions and echocardiographic E/e' were identified from PubMed, Scopus, Embase, and Cochrane Library databases...
March 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28298371/temporal-trends-in-treatment-and-outcomes-of-acute-myocardial-infarction-in-patients-with-chronic-obstructive-pulmonary-disease-a-nationwide-population-based-observational-study
#20
Tse-Hsuan Su, Shang-Hung Chang, Pei-Chun Chen, Yi-Ling Chan
BACKGROUND: Acute myocardial infarction is a major cause of hospitalization and death in patients with chronic obstructive pulmonary disease (COPD); however, temporal trends in the management and clinical outcomes of these patients remain unclear. METHODS AND RESULTS: We conducted an observational study by using a representative sample of 1 million beneficiaries from the Taiwan National Health Insurance Research Database. Comorbidities, in-hospital treatment, and outcomes were compared for patients with acute myocardial infarction with and without COPD between 2004 and 2013...
March 15, 2017: Journal of the American Heart Association
journal
journal
43995
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"