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Journal of the American Heart Association

Gian Paolo Novelli, Barbara Vasapollo, Herbert Valensise
No abstract text is available yet for this article.
July 14, 2018: Journal of the American Heart Association
Brent M Egan
No abstract text is available yet for this article.
July 14, 2018: Journal of the American Heart Association
Kelsey McLaughlin, Jianhong Zhang, Stephen J Lye, John D Parker, John C Kingdom
BACKGROUND: Hypertensive disorders complicating pregnancy are a major cause of maternal death. Our objective was to evaluate maternal clinical, hemodynamic, and placental prognostic indicators in a consolidated manner to identify women who develop hypertension in pregnancy. METHODS AND RESULTS: Twenty-six normotensive pregnant women from a specialized Placenta Clinic at increased risk of developing de novo hypertension and 20 normotensive healthy pregnant controls were recruited at 22 to 26 weeks' gestation...
July 14, 2018: Journal of the American Heart Association
K Michael Cummings, Pamela B Morris, Neal L Benowitz
No abstract text is available yet for this article.
July 14, 2018: Journal of the American Heart Association
Rana M Jaber, Mohammadhassan Mirbolouk, Andrew P DeFilippis, Wasim Maziak, Rachel Keith, Thomas Payne, Andrew Stokes, Emelia Benjamin, Aruni Bhatnagar, Ron Blankstein, Anshul Saxena, Michael J Blaha, Khurram Nasir
BACKGROUND: To examine the prevalence and patterns of recent electronic cigarette (e-cigarette) use in a nationally representative sample of US adults and adolescents. METHODS AND RESULTS: Using tobacco information from NHANES (National Health and Nutrition Examination Survey) 2013-2014, 5423 adults and 895 adolescents (aged 13-17 years) were included in this analysis. Demographic, tobacco use, and drug use information were self-reported. Recent e-cigarette use (within the previous 5 days) was stratified by smoking status...
July 14, 2018: Journal of the American Heart Association
Diana Jalal, Brandon Renner, Jennifer Laskowski, Erik Stites, James Cooper, Karissa Valente, Zhiying You, Loni Perrenoud, Moglie Le Quintrec, Ismaeel Muhamed, Uwe Christians, Jelena Klawitter, Margaret A Lindorfer, Ronald P Taylor, V Michael Holers, Joshua M Thurman
BACKGROUND: Endothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation correlates with endothelial dysfunction in CKD. METHODS AND RESULTS: We analyzed complement data of 30 healthy subjects, 30 patients with stage III/IV CKD, and 30 renal transplant recipients with stage III/IV CKD, evaluating the potential correlation of complement fragments with brachial artery flow-mediated dilation, Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and urinary albumin/creatinine ratio...
July 13, 2018: Journal of the American Heart Association
Yan Chen, Ying-Xian Liu, Wai-Kay Seto, Mei-Zhen Wu, Yu-Juan Yu, Yui-Ming Lam, Wing-Kuk Au, Daniel Chan, Ko-Yung Sit, Lai-Ming Ho, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: The Model for End-stage Liver Disease excluding international normalized ratio (MELD-XI) score and the modified MELD score with albumin replacing international normalized ratio (MELD-Albumin) score, which reflect both liver and renal function, have been reported as predictors of adverse events in liver and heart disease. Nonetheless, their prognostic value in patients undergoing tricuspid annuloplasty has not been addressed. METHODS AND RESULTS: A total of 394 patients who underwent tricuspid annuloplasty were evaluated...
July 13, 2018: Journal of the American Heart Association
Jennifer E Ho, Asya Lyass, Paul Courchesne, George Chen, Chunyu Liu, Xiaoyan Yin, Shih-Jen Hwang, Joseph M Massaro, Martin G Larson, Daniel Levy
BACKGROUND: The discovery of novel and highly predictive biomarkers of cardiovascular disease (CVD) has the potential to improve risk-stratification methods and may be informative regarding biological pathways contributing to disease. METHODS AND RESULTS: We used a discovery proteomic platform that targeted high-value proteins for CVD to ascertain 85 circulating protein biomarkers in 3523 Framingham Heart Study participants (mean age, 62 years; 53% women). Using multivariable-adjusted Cox models to account for clinical variables, we found 8 biomarkers associated with incident atherosclerotic CVD, 18 with incident heart failure, 38 with all-cause mortality, and 35 with CVD death (false discovery rate, q<0...
July 13, 2018: Journal of the American Heart Association
Tomoyo Sugiyama, Erika Yamamoto, Krzysztof Bryniarski, Lei Xing, Francesco Fracassi, Hang Lee, Ik-Kyung Jang
BACKGROUND: Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS: A total of 322 patients with acute coronary syndromes who underwent preintervention optical coherence tomography imaging of the culprit lesion were included. Culprit plaque characteristics were compared between patients with DM (n=95) and those without DM (n=227)...
July 13, 2018: Journal of the American Heart Association
Naghum Alfulaij, Franziska Meiners, Justin Michalek, Andrea L Small-Howard, Helen C Turner, Alexander J Stokes
No abstract text is available yet for this article.
July 13, 2018: Journal of the American Heart Association
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
BACKGROUND: The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. METHODS AND RESULTS: We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death...
July 12, 2018: Journal of the American Heart Association
Suveen Angraal, Rohan Khera, Yun Wang, Yuan Lu, Raymond Jean, Rachel P Dreyer, Arnar Geirsson, Nihar R Desai, Harlan M Krumholz
BACKGROUND: With over a decade of directed efforts to reduce sex and racial differences in coronary artery bypass grafting (CABG) utilization, and post-CABG outcomes, we sought to evaluate how the use of CABG and its outcomes have evolved in different sex and racial subgroups. METHODS AND RESULTS: Using data on all fee-for-service Medicare beneficiaries undergoing CABG in the United States from 1999 to 2014, we examined differences by sex and race in calendar-year trends for CABG utilization and post-CABG outcomes (in-hospital, 30-day, and 1-year mortality and 30-day readmission)...
July 12, 2018: Journal of the American Heart Association
Xiaoli Yang, Rongchuan Yue, Jun Zhang, Xiaoqun Zhang, Yukai Liu, Caiyu Chen, Xinquan Wang, Hao Luo, Wei Eric Wang, Xiongwen Chen, Huixia Judy Wang, Pedro A Jose, Hongyong Wang, Chunyu Zeng
BACKGROUND: Ischemia/reperfusion injury (IRI) is one of the most predominant complications of ischemic heart disease. Gastrin has emerged as a regulator of cardiovascular function, playing a key protective role in hypoxia. Serum gastrin levels are increased in patients with myocardial infarction, but the pathophysiogical significance of this finding is unknown. The purpose of this study was to determine whether and how gastrin protects cardiac myocytes from IRI. METHODS AND RESULTS: Adult male Sprague-Dawley rats were used in the experiments...
July 12, 2018: Journal of the American Heart Association
Bryon A Tompkins, Angela C Rieger, Victoria Florea, Monisha N Banerjee, Makoto Natsumeda, Evan D Nigh, Ana Marie Landin, Gianna M Rodriguez, Konstantinos E Hatzistergos, Ivonne Hernandez Schulman, Joshua M Hare
BACKGROUND: Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) differ in histopathology and prognosis. Although transendocardial delivery of mesenchymal stem cells is safe and provides cardiovascular benefits in both, a comparison of mesenchymal stem cell efficacy in ICM versus DCM has not been done. METHODS AND RESULTS: We conducted a subanalysis of 3 single-center, randomized, and blinded clinical trials: (1) TAC-HFT (Transendocardial Autologous Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells in Ischemic Heart Failure Trial); (2) POSEIDON (A Phase I/II, Randomized Pilot Study of the Comparative Safety and Efficacy of Transendocardial Injection of Autologous Mesenchymal Stem Cells Versus Allogeneic Mesenchymal Stem Cells in Patients With Chronic Ischemic Left Ventricular Dysfunction Secondary to Myocardial Infarction); and (3) POSEIDON-DCM (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy)...
July 12, 2018: Journal of the American Heart Association
Jiaqi Tang, Axin He, Na Li, Xueyi Chen, Xiuwen Zhou, Xiaorong Fan, Yanping Liu, Mengshu Zhang, Linglu Qi, Jianying Tao, Miao Sun, Zhice Xu
BACKGROUND: Magnesium sulfate (MgSO4 ) has been used as a common therapy for preeclampsia and eclampsia for many years. MgSO4 decreases peripheral vascular resistance so as to reduce maternal blood pressure. Whether placental blood vessels react to MgSO4 in the same patterns as that in maternal vessels is largely unknown. METHODS AND RESULTS: This study compared placental vessels (PV) versus nonplacental vessels (non-PV) in human and animal models. MgSO4 -caused vascular dilation was significantly weaker in PV than that in non-PV...
July 12, 2018: Journal of the American Heart Association
Itsuro Morishima, Kenji Okumura, Yasuhiro Morita, Yasunori Kanzaki, Kensuke Takagi, Ruka Yoshida, Hiroaki Nagai, Yoshihiro Ikai, Koichi Furui, Naoki Yoshioka, Hideyuki Tsuboi, Toyoaki Murohara
BACKGROUND: Hypothyroidism has been shown to contribute to enhanced atrial arrhythmogenesis, resulting in atrial fibrillation (AF) development in animal models and clinical populations. We aimed to elucidate whether high thyroid-stimulating hormone (TSH) levels are related to outcomes of catheter ablation of AF. METHODS AND RESULTS: Of 477 consecutive patients who underwent first-time pulmonary vein isolation-based radiofrequency catheter ablation of AF, 456 with TSH above the lower limit of the normal range (age, 65...
July 12, 2018: Journal of the American Heart Association
James M Shikany, Monika M Safford, Joanna Bryan, P K Newby, Joshua S Richman, Raegan W Durant, Todd M Brown, Suzanne E Judd
BACKGROUND: Previously, we reported on associations between dietary patterns and incident acute coronary heart disease (CHD) in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Here, we investigated the associations of dietary patterns and a dietary index with recurrent CHD events and all-cause mortality in REGARDS participants with existing CHD. METHODS AND RESULTS: We included data from 3562 participants with existing CHD in REGARDS...
July 12, 2018: Journal of the American Heart Association
S Justin Thomas, John N Booth, Chen Dai, Xuelin Li, Norrina Allen, David Calhoun, April P Carson, Samuel Gidding, Cora E Lewis, James M Shikany, Daichi Shimbo, Stephen Sidney, Paul Muntner
BACKGROUND: Blacks have higher blood pressure levels compared with whites beginning in childhood. Few data are available on racial differences in the incidence of hypertension from young adulthood through middle age. METHODS AND RESULTS: We calculated the cumulative incidence of hypertension from age 18 to 55 years among participants in the CARDIA (Coronary Artery Risk Development in Young Adults) study. Incident hypertension was defined by the first visit with mean systolic blood pressure ≥130 mm Hg, mean diastolic blood pressure ≥80 mm Hg, or self-reported use of antihypertensive medication...
July 11, 2018: Journal of the American Heart Association
Yang Gao, Deborah Stuart, Takamune Takahishi, Donald E Kohan
BACKGROUND: In vitro studies suggest that nephron nitric oxide synthase 3 (NOS3) modulates tubule Na+ transport. METHODS AND RESULTS: To assess nephron NOS3 relevance in vivo, knockout (KO) mice with doxycycline-inducible nephron-wide deletion of NOS3 were generated. During 1 week of salt loading, KO mice, as compared with controls, had higher arterial pressure and Na+ retention, a tendency towards reduced plasma renin concentration, and unchanged glomerular filtration rate...
July 11, 2018: Journal of the American Heart Association
Saraschandra Vallabhajosyula, Sri Harsha Patlolla, Harigopal Sandhyavenu, Saarwaani Vallabhajosyula, Gregory W Barsness, Shannon M Dunlay, Kevin L Greason, David R Holmes, Mackram F Eleid
BACKGROUND: There are limited data on the use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) or cardiopulmonary bypass (CPB) to provide hemodynamic support periprocedurally during transcatheter aortic valve replacement. This study sought to evaluate patients receiving transcatheter aortic valve replacement with concomitant use of CPB/VA-ECMO. METHODS AND RESULTS: We systematically reviewed the published literature from 2000 to 2018 for studies evaluating adult patients requiring CPB/VA-ECMO periprocedurally during transcatheter aortic valve replacement...
July 9, 2018: Journal of the American Heart Association
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