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Journal of the American Heart Association

Carl J Ade, Ryan M Broxterman, Jacqueline M Charvat, Thomas J Barstow
BACKGROUND: It is unknown whether the astronaut occupation or exposure to microgravity influences the risk of long-term cardiovascular disease (CVD). This study explored the effects of being a career National Aeronautics and Space Administration (NASA) astronaut on the risk for clinical CVD end points. METHODS AND RESULTS: During the Longitudinal Study of Astronaut Health, data were collected on 310 NASA astronauts and 981 nonastronaut NASA employees. The nonastronauts were matched to the astronauts on age, sex, and body mass index, to evaluate acute and chronic morbidity and mortality...
August 7, 2017: Journal of the American Heart Association
Sara Ahmadi-Abhari, Severine Sabia, Martin J Shipley, Mika Kivimäki, Archana Singh-Manoux, Adam Tabak, Carmel McEniery, Ian B Wilkinson, Eric J Brunner
BACKGROUND: Physical activity is associated with reduced cardiovascular disease risk, mainly through effects on atherosclerosis. Aortic stiffness may be an alternative mechanism. We examined whether patterns of physical activity and sedentary behavior are associated with rate of aortic stiffening. METHODS AND RESULTS: Carotid-femoral pulse wave velocity (PWV) was measured twice using applanation tonometry at mean ages 65 (in 2008/2009) and 70 (in 2012/2013) years in the Whitehall-II study (N=5196)...
August 7, 2017: Journal of the American Heart Association
Vojtech Melenovsky, Jan Benes, Janka Franekova, Jan Kovar, Barry A Borlaug, Marketa Segetova, Andrea Tura, Tereza Pelikanova
BACKGROUND: The mechanisms and relevance of impaired glucose homeostasis in advanced heart failure (HF) are poorly understood. The study goals were to examine glucose regulation, pancreatic endocrine function, and metabolic factors related to prognosis in patients with nondiabetic advanced HF. METHODS AND RESULTS: In total, 140 advanced HF patients without known diabetes mellitus and 21 sex-, age-, and body mass index-matched controls underwent body composition assessment, oral glucose tolerance testing, and measurement of glucose-regulating hormones to model pancreatic β-cell secretory response...
August 7, 2017: Journal of the American Heart Association
Zhen-Yu Zhang, Susana Ravassa, Esther Nkuipou-Kenfack, Wen-Yi Yang, Shona M Kerr, Thomas Koeck, Archie Campbell, Tatiana Kuznetsova, Harald Mischak, Sandosh Padmanabhan, Anna F Dominiczak, Christian Delles, Jan A Staessen
BACKGROUND: Detection of preclinical cardiac dysfunction and prognosis of left ventricular heart failure (HF) would allow targeted intervention, and appears to be the most promising approach in its management. Novel biomarker panels may support this approach and provide new insights into the pathophysiology. METHODS AND RESULTS: A retrospective comparison of urinary proteomic profiles generated by mass spectrometric analysis from 49 HF patients, 36 patients who progressed to HF within 2...
August 7, 2017: Journal of the American Heart Association
Sanne Bøjet Larsen, Erik Lerkevang Grove, Søs Neergaard-Petersen, Morten Würtz, Anne-Mette Hvas, Steen Dalby Kristensen
BACKGROUND: Increased platelet aggregation during antiplatelet therapy may predict cardiovascular events in patients with coronary artery disease. The majority of these patients receive aspirin monotherapy. We aimed to investigate whether high platelet-aggregation levels predict cardiovascular events in stable coronary artery disease patients treated with aspirin. METHODS AND RESULTS: We included 900 stable coronary artery disease patients with either previous myocardial infarction, type 2 diabetes mellitus, or both...
August 5, 2017: Journal of the American Heart Association
Ernest Spitzer, Martina Frei, Serge Zaugg, Susanne Hadorn, Henning Kelbaek, Miodrag Ostojic, Andreas Baumbach, David Tüller, Marco Roffi, Thomas Engstrom, Giovanni Pedrazzini, Vladan Vukcevic, Michael Magro, Ran Kornowski, Thomas F Lüscher, Clemens von Birgelen, Dik Heg, Stephan Windecker, Lorenz Räber
BACKGROUND: Rehospitalizations (RHs) after ST-elevation myocardial infarction carry a high economic burden and may deteriorate quality of life. Characterizing patients at higher risk may allow the design of preventive measures. We studied the frequency, reasons, and predictors for unplanned cardiac and noncardiac RHs in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. METHODS AND RESULTS: In this post-hoc analysis of the COMFORTABLE AMI (Comparison of Biolimus Eluted From an Erodible Stent Coating With Bare Metal Stents in Acute ST-Elevation Myocardial Infarction; NCT00962416) trial including 1137 patients, unplanned cardiac and noncardiac RHs occurred in 133 (11...
August 5, 2017: Journal of the American Heart Association
Yuan-I Min, Pramod Anugu, Kenneth R Butler, Tara A Hartley, Stanford Mwasongwe, Arnita F Norwood, Mario Sims, Wei Wang, Karen P Winters, Adolfo Correa
BACKGROUND: Black persons have an excess burden of cardiovascular disease (CVD) compared with white persons. This burden persists after adjustment for socioeconomic status and other known CVD risk factors. This study evaluated the CVD burden and the socioeconomic gradient of CVD among black participants in the JHS (Jackson Heart Study). METHODS AND RESULTS: CVD burden was evaluated by comparing the observed prevalence of myocardial infarction, stroke, and hypertension in the JHS at baseline (2000-2004) with the expected prevalence according to US national surveys during a similar time period...
August 4, 2017: Journal of the American Heart Association
Andraea Van Hulst, Tracie A Barnett, Gilles Paradis, Marie-Hélène Roy-Gagnon, Lilianne Gomez-Lopez, Mélanie Henderson
BACKGROUND: Different pathways likely underlie the association between early weight gain and cardiovascular disease risk. We examined whether birth weight for length relationship and weight gain up to 2 years of age are associated with lipid profiles and blood pressure (BP) in early adolescence and determined whether childhood adiposity mediates these associations. METHODS AND RESULTS: Data from QUALITY (Quebec Adipose and Lifestyle Investigation in Youth), a cohort of white children with parental history of obesity, were analyzed (n=395)...
August 4, 2017: Journal of the American Heart Association
Maria Hennig, Saskia Fiedler, Christian Jux, Ludwig Thierfelder, Jörg-Detlef Drenckhahn
BACKGROUND: Fetal growth impacts cardiovascular health throughout postnatal life in humans. Various animal models of intrauterine growth restriction exhibit reduced heart size at birth, which negatively influences cardiac function in adulthood. The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and growth factor availability with cell growth, thereby regulating organ size. This study aimed at elucidating a possible involvement of mTORC1 in intrauterine growth restriction and prenatal heart growth...
August 4, 2017: Journal of the American Heart Association
Arka Chatterjee, Navkaranbir S Bajaj, William S McMahon, Marc G Cribbs, Jeremy S White, Amrita Mukherjee, Mark A Law
BACKGROUND: Transcatheter pulmonary valve implantation is approved for the treatment of dysfunctional right ventricle to pulmonary artery conduits. However, the literature is limited because of a small patient population, and it does not reflect changing procedural practice patterns over the last decade. METHODS AND RESULTS: A comprehensive search of Medline and Scopus databases from inception through August 31, 2016 was conducted using predefined criteria. We included studies reporting transcatheter pulmonary valve implantation in at least 5 patients with a follow-up duration of 6 months or more...
August 4, 2017: Journal of the American Heart Association
Jin-Seok Kim, Seung Yong Shin, Jun Hyuk Kang, Hwan Seok Yong, Jin Oh Na, Cheol Ung Choi, Seong Hwan Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang, Young-Hoon Kim, Hong Euy Lim
BACKGROUND: Epicardial adipose tissue (EAT) is known to play an important role in atrial fibrillation substrate remodeling; however, the influence of sex on the association between EAT and left atrial (LA) transport function has not been elucidated. METHODS AND RESULTS: Of the 514 patients who underwent an index atrial fibrillation ablation procedure, 123 postmenopausal women with no history of hormone replacement therapy and 123 men who were matched for age, body mass index, type of atrial fibrillation, and CHADS2 score were enrolled...
August 4, 2017: Journal of the American Heart Association
Kaylin T Nguyen, Eric Vittinghoff, Thomas A Dewland, Jonathan W Dukes, Elsayed Z Soliman, Phyllis K Stein, John S Gottdiener, Alvaro Alonso, Lin Y Chen, Bruce M Psaty, Susan R Heckbert, Gregory M Marcus
BACKGROUND: Atrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality. METHODS AND RESULTS: We utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort...
August 3, 2017: Journal of the American Heart Association
Mark E Dunlap, Paul J Hauptman, Alpesh N Amin, Sandra L Chase, Joseph A Chiodo, Jun R Chiong, Joseph F Dasta
BACKGROUND: Hyponatremia (HN) occurs commonly in patients with acute heart failure and confers a worse prognosis. Current HN treatment varies widely, with no consensus. This study recorded treatment practices currently used for patients hospitalized with acute heart failure and HN. METHODS AND RESULTS: Data were collected prospectively from 146 US sites on patients hospitalized with acute heart failure and HN (serum sodium concentration [Na(+)] ≤130 mEq/L) present at admission or developing in the hospital...
August 3, 2017: Journal of the American Heart Association
Qianqian Li, Yuanyuan Zhao, Gang Wu, Shanshan Chen, Yingchao Zhou, Sisi Li, Mengchen Zhou, Qian Fan, Jielin Pu, Kui Hong, Xiang Cheng, Qing Kenneth Wang, Xin Tu
BACKGROUND: Idiopathic ventricular tachycardia (VT) is a type of cardiac arrhythmia occurring in structurally normal hearts. The heritability of idiopathic VT remains to be clarified, and numerous genetic factors responsible for development of idiopathic VT are as yet unclear. Variations in FGF12 (fibroblast growth factor 12), which is expressed in the human ventricle and modulates the cardiac Na(+) channel NaV1.5, may play an important role in the genetic pathogenesis of VT. METHODS AND RESULTS: We tested the hypothesis that genetic variations in FGF12 are associated with VT in 2 independent Chinese cohorts and resequenced all the exons and exon-intron boundaries and the 5' and 3' untranslated regions of FGF12 in 320 unrelated participants with idiopathic VT...
August 3, 2017: Journal of the American Heart Association
Julian C van Capelleveen, Andrea E Bochem, S Matthijs Boekholdt, Samia Mora, Ron C Hoogeveen, Christie M Ballantyne, Paul M Ridker, Wensheng Sun, Philip J Barter, Alan R Tall, Aeilko H Zwinderman, John J P Kastelein, Nick J Wareham, Kay-Tee Khaw, G Kees Hovingh
BACKGROUND: The contribution of apolipoprotein A-I (apoA-I) to coronary heart disease (CHD) risk stratification over and above high-density lipoprotein cholesterol (HDL-C) is unclear. We studied the associations between plasma levels of HDL-C and apoA-I, either alone or combined, with risk of CHD events and cardiovascular risk factors among apparently healthy men and women. METHODS AND RESULTS: HDL-C and apoA-I levels were measured among 17 661 participants of the EPIC (European Prospective Investigation into Cancer)-Norfolk prospective population study...
August 3, 2017: Journal of the American Heart Association
Peiying Li, Long Wang, Yuxi Zhou, Yu Gan, Wen Zhu, Yuguo Xia, Xiaoyan Jiang, Simon Watkins, Alberto Vazquez, Angus W Thomson, Jun Chen, Weifeng Yu, Xiaoming Hu
BACKGROUND: Despite recent evidence demonstrating a potent protective effect of adoptively transferred regulatory T cells (Tregs) in ischemic stroke, the mechanism for Treg mobilization and activation in the ischemic brain is, remarkably, unknown. This study determines the role of C-C chemokine receptor type 5 (CCR5) in mediating the docking and activation of transferred Tregs in their protection of early blood-brain barrier disruption after stroke. METHODS AND RESULTS: Adoptive transfer of CCR5(-/-) Tregs failed to reduce brain infarct or neurological deficits, indicating an indispensable role of CCR5 in Treg-afforded protection against cerebral ischemia...
August 2, 2017: Journal of the American Heart Association
Shiqiang Xiong, Bin Wang, Shaoyang Lin, Hexuan Zhang, Yingsha Li, Xing Wei, Yuanting Cui, Xiao Wei, Zongshi Lu, Peng Gao, Li Li, Zhigang Zhao, Daoyan Liu, Zhiming Zhu
BACKGROUND: Environmental cold-induced hypertension is common, but how to treat cold-induced hypertension remains an obstacle. Transient receptor potential melastatin subtype 8 (TRPM8) is a mild cold-sensing nonselective cation channel that is activated by menthol. Little is known about the effect of TRPM8 activation by menthol on mitochondrial Ca(2+) homeostasis and the vascular function in cold-induced hypertension. METHODS AND RESULTS: Primary vascular smooth muscle cells from wild-type or Trpm8(-/-) mice were cultured...
August 2, 2017: Journal of the American Heart Association
Wan Feng, Guangxia Chen, Dawei Cai, Song Zhao, Jiafei Cheng, Hong Shen
BACKGROUND: Several immune-mediated diseases have been shown to be associated with an increased risk of cardiovascular disease. However, studies evaluating the association between inflammatory bowel disease and risk of cardiovascular disease reported inconsistent results. We assessed the association between inflammatory bowel disease and risk of ischemic heart disease in a meta-analysis of cohort studies. METHODS AND RESULTS: We conducted a literature search of PubMed and Embase up to October 2016 to identify relevant studies...
August 2, 2017: Journal of the American Heart Association
Meng Lee, Jeffrey L Saver, Yi-Ling Wu, Sung-Chun Tang, Jiann-Der Lee, Neal M Rao, Hui-Hsuan Wang, Jiann-Shing Jeng, Tsong-Hai Lee, Pei-Chun Chen, Bruce Ovbiagele
BACKGROUND: In-hospital discontinuation of statins has been linked to poorer early stroke outcomes, but the consequences of postdischarge discontinuation or dose reduction of statin treatment are unknown. The objective of this study was to explore the effects of statin discontinuation or statin dose reduction on recurrent stroke risk. METHODS AND RESULTS: We conducted a nationwide cohort study using the data from the Taiwan National Health Insurance Research Database...
August 2, 2017: Journal of the American Heart Association
Karen C Albright, Virginia J Howard, George Howard, Paul Muntner, Vera Bittner, Monika M Safford, Amelia K Boehme, J David Rhodes, T Mark Beasley, Suzanne E Judd, Leslie A McClure, Nita Limdi, Justin Blackburn
BACKGROUND: Stroke is a costly and debilitating disease that disproportionately affects blacks. Despite the efficacy of statins, evidence suggests racial disparities may exist in statin prescribing. METHODS AND RESULTS: We analyzed discharge medications for participants hospitalized for an ischemic stroke during follow-up of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Medications on admission and discharge were abstracted from medical records...
August 2, 2017: Journal of the American Heart Association
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