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Journal of the American Heart Association

Fang Wu, Qingfeng Ma, Haiqing Song, Xiuhai Guo, Marcio A Diniz, Shlee S Song, Nestor R Gonzalez, Xiaoming Bi, Xunming Ji, Debiao Li, Qi Yang, Zhaoyang Fan
BACKGROUND: Intracranial atherosclerotic disease tends to affect multiple arterial segments. Using whole-brain vessel wall imaging, we sought to study the differences in plaque features among various types of plaques in patients with a recent unilateral anterior circulation ischemic stroke. METHODS AND RESULTS: Sixty-one patients with unilateral anterior circulation ischemic stroke were referred to undergo whole-brain vessel wall imaging (before and after contrast) within 1 month of symptom onset for intracranial atherosclerotic disease evaluations...
July 22, 2018: Journal of the American Heart Association
Gilles R Dagenais, Hyejung Jung, Eva Lonn, Peter M Bogaty, Mahshid Dehghan, Claes Held, Alvaro Avezum, Petr Jansky, Matyàs Keltai, Lawrence A Leiter, Patricio Lopez-Jaramillo, William D Toff, Jackie Bosch, Salim Yusuf
BACKGROUND: It is not clear whether the effects of lipid-lowering or antihypertensive medications are influenced by adherence to healthy lifestyle factors. We assessed the effects of both drug interventions in subgroups by the number of healthy lifestyle factors in participants in the HOPE-3 (Heart Outcomes Prevention Evaluation) trial. METHODS AND RESULTS: In this primary prevention trial, 4 healthy lifestyle factors (nonsmoking status, physical activity, optimal body weight, and healthy diet) were recorded in 12 521 participants who were at intermediate risk of cardiovascular disease (CVD) and were randomized to rosuvastatin, candesartan/hydrochlorothiazide, their combination, or matched placebos...
July 22, 2018: Journal of the American Heart Association
Guy Rozen, Seyed Mohammadreza Hosseini, M Ihsan Kaadan, Yitschak Biton, E Kevin Heist, Mark Vangel, Moussa C Mansour, Jeremy N Ruskin
BACKGROUND: Atrial fibrillation (AF) is an increasingly prevalent public health problem and one of the most common causes of emergency department (ED) visits. We aimed to investigate the trends in ED visits and hospital admissions for AF. METHODS AND RESULTS: This is a repeated cross-sectional analysis of ED visit-level data from the Nationwide Emergency Department Sample for 2007 to 2014. We identified adults who visited EDs in the United States, with a principal diagnosis of AF...
July 20, 2018: Journal of the American Heart Association
Diem T T Tran, Jack V Tu, Jean-Yves Dupuis, Anan Bader Eddeen, Louise Y Sun
BACKGROUND: Frailty is increasing in prevalence and poses a formidable challenge for clinicians. The cardiac surgery literature consists primarily of small single-center studies with limited follow-up, and the epidemiological features of frailty remain to be elucidated in long-term follow-up. METHODS AND RESULTS: We conducted a population-based, retrospective, cohort study in Ontario, Canada, between 2008 and 2015. Frailty was defined using the Johns Hopkins Adjusted Clinical Groups frailty indicator (a multidimensional instrument validated for research using administrative data)...
July 20, 2018: Journal of the American Heart Association
Christopher J Nicholson, Kuldeep Singh, Robert J Saphirstein, Yuan Z Gao, Qian Li, Joanna G Chiu, Paul Leavis, Germaine C Verwoert, G F Mitchell, Tyrone Porter, Kathleen G Morgan
BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole. This shock absorber function is impaired with age because of aortic stiffening. METHODS AND RESULTS: We examined the contribution of common genetic variation to aortic stiffness in humans by interrogating results from the AortaGen Consortium genome-wide association study of carotid-femoral pulse wave velocity...
July 18, 2018: Journal of the American Heart Association
Hanan Qasim, Zubair A Karim, Juan C Silva-Espinoza, Fadi T Khasawneh, José O Rivera, Cameron C Ellis, Stephanie L Bauer, Igor C Almeida, Fatima Z Alshbool
BACKGROUND: Cardiovascular disease is the main cause of death in the United States, with smoking being the primary preventable cause of premature death, and thrombosis being the main mechanism of cardiovascular mortality in smokers. Due to the perception that electronic/e-cigarettes are "safer/less harmful" than conventional cigarettes, their usage-among a variety of ages-has increased tremendously during the past decade. Notably, there are limited studies regarding the negative effects of e-cigarettes on the cardiovascular system, which is also the subject of significant debate...
July 18, 2018: Journal of the American Heart Association
Nadine J Kubesch, Jeanette Therming Jørgensen, Barbara Hoffmann, Steffen Loft, Mark J Nieuwenhuijsen, Ole Raaschou-Nielsen, Marie Pedersen, Ole Hertel, Kim Overvad, Anne Tjønneland, Eva Prescot, Zorana J Andersen
BACKGROUND: Physical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure-time and transport-related physical activities on the risk of myocardial infarction (MI), and whether potential benefits on MI are reduced by exposure to traffic-related air pollution. METHODS AND RESULTS: A group of 57 053 participants (50-65 years of age) from the Danish Diet, Cancer, and Health cohort reported physical activity at baseline (1993-1997) and were linked to registry data on hospital contacts and out-of-hospital deaths caused by MI, until December 2015...
July 18, 2018: Journal of the American Heart Association
Clancy Read, Alison G Mitchell, Jessica L de Dassel, Clair Scrine, David Hendrickx, Ross S Bailie, Vanessa Johnston, Graeme P Maguire, Rosalie Schultz, Jonathan R Carapetis, Anna P Ralph
BACKGROUND: Rheumatic heart disease is a high-burden condition in Australian Aboriginal communities. We evaluated a stepped-wedge, community, randomized trial at 10 Aboriginal communities from 2013 to 2015. A multifaceted intervention was implemented using quality improvement and chronic care model approaches to improve delivery of penicillin prophylaxis for rheumatic heart disease. The trial did not improve penicillin adherence. This mixed-methods evaluation, designed a priori , aimed to determine the association between methodological approaches and outcomes...
July 17, 2018: Journal of the American Heart Association
Anna P Ralph, Jessica L de Dassel, Adrienne Kirby, Clancy Read, Alison G Mitchell, Graeme P Maguire, Bart J Currie, Ross S Bailie, Vanessa Johnston, Jonathan R Carapetis
BACKGROUND: Health system strengthening is needed to improve delivery of secondary prophylaxis against rheumatic heart disease. METHODS AND RESULTS: We undertook a stepped-wedge, randomized trial in northern Australia. Five pairs of Indigenous community clinics entered the study at 3-month steps. Study phases comprised a 12 month baseline phase, 3 month transition phase, 12 month intensive phase and a 3- to 12-month maintenance phase. Clinics received a multicomponent intervention supporting activities to improve penicillin delivery, aligned with the chronic care model, with continuous quality-improvement feedback on adherence...
July 17, 2018: Journal of the American Heart Association
Gian Paolo Novelli, Barbara Vasapollo, Herbert Valensise
No abstract text is available yet for this article.
July 14, 2018: Journal of the American Heart Association
Brent M Egan
No abstract text is available yet for this article.
July 14, 2018: Journal of the American Heart Association
Kelsey McLaughlin, Jianhong Zhang, Stephen J Lye, John D Parker, John C Kingdom
BACKGROUND: Hypertensive disorders complicating pregnancy are a major cause of maternal death. Our objective was to evaluate maternal clinical, hemodynamic, and placental prognostic indicators in a consolidated manner to identify women who develop hypertension in pregnancy. METHODS AND RESULTS: Twenty-six normotensive pregnant women from a specialized Placenta Clinic at increased risk of developing de novo hypertension and 20 normotensive healthy pregnant controls were recruited at 22 to 26 weeks' gestation...
July 14, 2018: Journal of the American Heart Association
K Michael Cummings, Pamela B Morris, Neal L Benowitz
No abstract text is available yet for this article.
July 14, 2018: Journal of the American Heart Association
Rana M Jaber, Mohammadhassan Mirbolouk, Andrew P DeFilippis, Wasim Maziak, Rachel Keith, Thomas Payne, Andrew Stokes, Emelia Benjamin, Aruni Bhatnagar, Ron Blankstein, Anshul Saxena, Michael J Blaha, Khurram Nasir
BACKGROUND: To examine the prevalence and patterns of recent electronic cigarette (e-cigarette) use in a nationally representative sample of US adults and adolescents. METHODS AND RESULTS: Using tobacco information from NHANES (National Health and Nutrition Examination Survey) 2013-2014, 5423 adults and 895 adolescents (aged 13-17 years) were included in this analysis. Demographic, tobacco use, and drug use information were self-reported. Recent e-cigarette use (within the previous 5 days) was stratified by smoking status...
July 14, 2018: Journal of the American Heart Association
Diana Jalal, Brandon Renner, Jennifer Laskowski, Erik Stites, James Cooper, Karissa Valente, Zhiying You, Loni Perrenoud, Moglie Le Quintrec, Ismaeel Muhamed, Uwe Christians, Jelena Klawitter, Margaret A Lindorfer, Ronald P Taylor, V Michael Holers, Joshua M Thurman
BACKGROUND: Endothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation correlates with endothelial dysfunction in CKD. METHODS AND RESULTS: We analyzed complement data of 30 healthy subjects, 30 patients with stage III/IV CKD, and 30 renal transplant recipients with stage III/IV CKD, evaluating the potential correlation of complement fragments with brachial artery flow-mediated dilation, Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and urinary albumin/creatinine ratio...
July 13, 2018: Journal of the American Heart Association
Yan Chen, Ying-Xian Liu, Wai-Kay Seto, Mei-Zhen Wu, Yu-Juan Yu, Yui-Ming Lam, Wing-Kuk Au, Daniel Chan, Ko-Yung Sit, Lai-Ming Ho, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: The Model for End-stage Liver Disease excluding international normalized ratio (MELD-XI) score and the modified MELD score with albumin replacing international normalized ratio (MELD-Albumin) score, which reflect both liver and renal function, have been reported as predictors of adverse events in liver and heart disease. Nonetheless, their prognostic value in patients undergoing tricuspid annuloplasty has not been addressed. METHODS AND RESULTS: A total of 394 patients who underwent tricuspid annuloplasty were evaluated...
July 13, 2018: Journal of the American Heart Association
Jennifer E Ho, Asya Lyass, Paul Courchesne, George Chen, Chunyu Liu, Xiaoyan Yin, Shih-Jen Hwang, Joseph M Massaro, Martin G Larson, Daniel Levy
BACKGROUND: The discovery of novel and highly predictive biomarkers of cardiovascular disease (CVD) has the potential to improve risk-stratification methods and may be informative regarding biological pathways contributing to disease. METHODS AND RESULTS: We used a discovery proteomic platform that targeted high-value proteins for CVD to ascertain 85 circulating protein biomarkers in 3523 Framingham Heart Study participants (mean age, 62 years; 53% women). Using multivariable-adjusted Cox models to account for clinical variables, we found 8 biomarkers associated with incident atherosclerotic CVD, 18 with incident heart failure, 38 with all-cause mortality, and 35 with CVD death (false discovery rate, q<0...
July 13, 2018: Journal of the American Heart Association
Tomoyo Sugiyama, Erika Yamamoto, Krzysztof Bryniarski, Lei Xing, Francesco Fracassi, Hang Lee, Ik-Kyung Jang
BACKGROUND: Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS: A total of 322 patients with acute coronary syndromes who underwent preintervention optical coherence tomography imaging of the culprit lesion were included. Culprit plaque characteristics were compared between patients with DM (n=95) and those without DM (n=227)...
July 13, 2018: Journal of the American Heart Association
Naghum Alfulaij, Franziska Meiners, Justin Michalek, Andrea L Small-Howard, Helen C Turner, Alexander J Stokes
No abstract text is available yet for this article.
July 13, 2018: Journal of the American Heart Association
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
BACKGROUND: The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. METHODS AND RESULTS: We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death...
July 12, 2018: Journal of the American Heart Association
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