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Journal of the American Heart Association

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https://www.readbyqxmd.com/read/29467150/high-sensitivity-troponin-i-levels-and-coronary-artery-disease-severity-progression-and-long-term-outcomes
#1
Ayman Samman Tahhan, Pratik Sandesara, Salim S Hayek, Muhammad Hammadah, Ayman Alkhoder, Heval M Kelli, Matthew Topel, Wesley T O'Neal, Nima Ghasemzadeh, Yi-An Ko, Mohamad Mazen Gafeer, Naser Abdelhadi, Fahad Choudhary, Keyur Patel, Agim Beshiri, Gillian Murtagh, Jonathan Kim, Peter Wilson, Leslee Shaw, Viola Vaccarino, Stephen E Epstein, Laurence Sperling, Arshed A Quyyumi
BACKGROUND: The associations between high-sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severity and progression of CAD and whether the predictive value of hsTnI level for incident cardiovascular outcomes is independent of CAD severity. METHODS AND RESULTS: In 3087 patients (aged 63±12 years, 64% men) undergoing cardiac catheterization without evidence of acute myocardial infarction, the severity of CAD was calculated by the number of major coronary arteries with ≥50% stenosis and the Gensini score...
February 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29455158/american-heart-association-s-life-s-simple-7-at-middle-age-and-prognosis-after-myocardial-infarction-in-later-life
#2
Yejin Mok, Yingying Sang, Shoshana H Ballew, Casey M Rebholz, Wayne D Rosamond, Gerardo Heiss, Aaron R Folsom, Josef Coresh, Kunihiro Matsushita
BACKGROUND: The American Heart Association recommends focusing on 7 health factors (Life's Simple 7) for primordial prevention of cardiovascular health. However, whether greater adherence to Life's Simple 7 in midlife improves prognosis after myocardial infarction (MI) in later life is unknown. METHODS AND RESULTS: In 1277 participants who developed MI during the ARIC (Atherosclerosis Risk in Communities) Study follow-up, a 14-point score of Life's Simple 7 was constructed according to the status (2 points for ideal, 1 point for intermediate, and 0 points for poor) of each of 7 factors (smoking, adiposity, physical activity, diet, total cholesterol, blood pressure, and fasting glucose) at baseline (1987-1989)...
February 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29455157/improving-outcomes-after-myocardial-infarction-in-the-us-population
#3
EDITORIAL
Waleed T Kayani, Christie M Ballantyne
No abstract text is available yet for this article.
February 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29453309/sutureless-perceval-aortic-valve-versus-conventional-stented-bioprostheses-meta-analysis-of-postoperative-and-midterm-results-in-isolated-aortic-valve-replacement
#4
REVIEW
Massimo Meco, Andrea Montisci, Antonio Miceli, Paolo Panisi, Francesco Donatelli, Silvia Cirri, Matteo Ferrarini, Antonio Lio, Mattia Glauber
BACKGROUND: Aortic stenosis is the most common valvular disease and has a dismal prognosis without surgical treatment. The aim of this meta-analysis was to quantitatively assess the comparative effectiveness of the Perceval (LivaNova) valve versus conventional aortic bioprostheses. METHODS AND RESULTS: A total of 6 comparative studies were identified, including 639 and 760 patients who underwent, respectively, aortic valve replacement with the Perceval sutureless valve (P group) and with a conventional bioprosthesis (C group)...
February 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29453308/sex-specific-mechanisms-of-resistance-vessel-endothelial-dysfunction-induced-by-cardiometabolic-risk-factors
#5
Ana P Davel, Qing Lu, M Elizabeth Moss, Sitara Rao, Imran J Anwar, Jennifer J DuPont, Iris Z Jaffe
BACKGROUND: The incidence of obesity is rising, particularly among women. Microvascular dysfunction is more common with female sex, obesity, and hyperlipidemia and predicts adverse cardiovascular outcomes, but the molecular mechanisms are unclear. Because obesity is associated with mineralocorticoid receptor (MR) activation, we tested the hypothesis that MR in endothelial cells contribute to sex differences in resistance vessel dysfunction in response to cardiometabolic risk factors. METHODS AND RESULTS: Male and female endothelial cell-specific MR knockout mice and MR-intact littermates were randomized to high-fat-diet-induced obesity or obesity with hyperlipidemia induced by adeno-associated virus-based vector targeting transfer of the mutant stable form (DY mutation) of the human PCSK9 (proprotein convertase subtilisin/kexin type 9) gene and compared with control diet...
February 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29453307/delirium-in-the-cardiac-intensive-care-unit
#6
REVIEW
Khalil Ibrahim, Cian P McCarthy, Killian J McCarthy, Charles H Brown, Dale M Needham, James L Januzzi, John W McEvoy
No abstract text is available yet for this article.
February 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29453306/acute-pressor-response-to-psychosocial-stress-is-dependent-on-endothelium-derived-endothelin-1
#7
Brandon M Fox, Bryan K Becker, Analia S Loria, Kelly A Hyndman, Chunhua Jin, Hannah Clark, Robin Johns, Masashi Yanagisawa, David M Pollock, Jennifer S Pollock
BACKGROUND: Acute psychosocial stress provokes increases in circulating endothelin-1 (ET-1) levels in humans and animal models. However, key questions about the physiological function and cellular source of stress-induced ET-1 remain unanswered. We hypothesized that endothelium-derived ET-1 contributes to the acute pressor response to stress via activation of the endothelin A receptor. METHODS AND RESULTS: Adult male vascular endothelium-specific ET-1 knockout mice and control mice that were homozygous for the floxed allele were exposed to acute psychosocial stress in the form of cage switch stress (CSS), with blood pressure measured by telemetry...
February 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29453305/frequency-and-outcomes-of-reduced-dose-non-vitamin-k-antagonist-anticoagulants-results-from-orbit-af-ii-the-outcomes-registry-for-better-informed-treatment-of-atrial-fibrillation-ii
#8
Benjamin A Steinberg, Peter Shrader, Karen Pieper, Laine Thomas, Larry A Allen, Jack Ansell, Paul S Chan, Michael D Ezekowitz, Gregg C Fonarow, James V Freeman, Bernard J Gersh, Peter R Kowey, Kenneth W Mahaffey, Gerald V Naccarelli, James A Reiffel, Daniel E Singer, Eric D Peterson, Jonathan P Piccini
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are indicated for stroke prevention in atrial fibrillation (AF) but require lower doses in certain patients. We sought to describe the frequency, appropriateness (according to Food and Drug Administration labeling), and outcomes of patients prescribed reduced doses of NOACs in community practice. METHODS AND RESULTS: We analyzed data from the ORBIT-AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II) registry, a prospective, national, observational registry of AF patients...
February 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29449274/clinical-relevance-of-functionally-insignificant-moderate-coronary-artery-stenosis-assessed-by-3-vessel-fractional-flow-reserve-measurement
#9
Jonghanne Park, Joo Myung Lee, Bon-Kwon Koo, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Doyeon Hwang, Jinlong Zhang, Xinyang Hu, JianAn Wang, Fei Ye, Shaoliang Chen, Junqing Yang, Jiyan Chen, Nobuhiro Tanaka, Hiroyoshi Yokoi, Hitoshi Matsuo, Hiroaki Takashima, Yasutsugu Shiono, Takashi Akasaka
BACKGROUND: Understanding of the risk conferred by functionally insignificant lesions in multiple coronary vessels is limited. We investigated the prognostic implications of coronary artery disease (CAD) based on 3-vessel fractional flow reserve (FFR). METHODS AND RESULTS: A total of 1,136 patients underwent FFR measurement in the 3 major epicardial arteries. We defined vessels with "Moderate CAD" as vessels with FFR, 0.81 to 0.87. Patients were classified into Group 1: No apparent CAD (FFR>0...
February 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29449273/novel-patient-centered-approach-to-facilitate-same-day-discharge-in-patients-undergoing-elective-percutaneous-coronary-intervention
#10
Amit P Amin, Patricia Crimmins-Reda, Samantha Miller, Brandon Rahn, Mary Caruso, Andrew Pierce, Brandy Dennis, Marissa Pendegraft, Katrine Sorensen, Howard I Kurz, John M Lasala, Alan Zajarias, Richard G Bach, Hemant Kulkarni, Jasvindar Singh
BACKGROUND: Same-day discharge (SDD) after elective percutaneous coronary intervention is safe, less costly, and preferred by patients, but it is usually performed in low-risk patients, if at all. To increase the appropriate use of SDD in more complex patients, we implemented a "patient-centered" protocol based on risk of complications at Barnes-Jewish Hospital. METHODS AND RESULTS: Our objectives were as follows: (1) to evaluate time trends in SDD; (2) to compare (a) mortality, bleeding, and acute kidney injury, (b) patient satisfaction, and (c) hospital costs by SDD versus no SDD (NSDD); and (3) to compare SDD eligibility by our patient-centered approach versus Society for Cardiovascular Angiography and Interventions guidelines...
February 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29449272/differential-clinical-outcomes-between-angiographic-complete-versus-incomplete-coronary-revascularization-according-to-the-presence-of-chronic-kidney-disease-in-the-drug-eluting-stent-era
#11
Jihoon Kim, Joo Myung Lee, Ki Hong Choi, Tae-Min Rhee, Doyeon Hwang, Jonghanne Park, Chul Ahn, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon
BACKGROUND: There are limited data regarding the prognostic impact of angiographic complete revascularization (CR) in patients with chronic kidney disease (CKD). We sought to investigate the differential prognostic impact of angiographic CR over incomplete revascularization (IR), according to the presence of CKD in the drug-eluting stent era. METHODS AND RESULTS: Between 2003 and 2011 at Samsung Medical Center, consecutive patients with multivessel disease were stratified by the presence of CKD (estimated glomerular filtration rate <60 mL/min per 1...
February 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29444774/comparison-between-different-strategies-of-rheumatic-heart-disease-echocardiographic-screening-in-brazil-data-from-the-provar-rheumatic-valve-disease-screening-program-study
#12
Bruno R Nascimento, Craig Sable, Maria Carmo P Nunes, Adriana C Diamantino, Kaciane K B Oliveira, Cassio M Oliveira, Zilda Maria A Meira, Sandra Regina T Castilho, Júlia P A Santos, Letícia Maria M Rabelo, Karlla C A Lauriano, Gabriel A L Carmo, Allison Tompsett, Antonio Luiz P Ribeiro, Andrea Z Beaton
BACKGROUND: Considering the limited accuracy of clinical examination for early diagnosis of rheumatic heart disease (RHD), echocardiography has emerged as an important epidemiological tool. The ideal setting for screening is yet to be defined. We aimed to evaluate the prevalence and pattern of latent RHD in schoolchildren (aged 5-18 years) and to compare effectiveness of screening between public schools, private schools, and primary care centers in Minas Gerais, Brazil. METHODS AND RESULTS: The PROVAR (Rheumatic Valve Disease Screening Program) study uses nonexperts and portable and handheld devices for RHD echocardiographic screening, with remote interpretation by telemedicine, according to the 2012 World Heart Federation criteria...
February 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29444773/lung-function-inflammation-and-endothelin-1-in-congenital-heart-disease-associated-pulmonary-arterial-hypertension
#13
Andrew Low, Sarah George, Luke Howard, Nicholas Bell, Ann Millar, Robert M R Tulloh
BACKGROUND: Breathlessness is the most common symptom in people with pulmonary arterial hypertension and congenital heart disease (CHD-APAH), previously thought to be caused by worsening PAH, but perhaps also by inflammation and abnormalities of lung function. We studied lung function and airway inflammation in patients with CHD-APAH and compared the results with controls. METHODS AND RESULTS: Sixty people were recruited into the study: 20 CHD-APAH, 20 CHD controls, and 20 healthy controls...
February 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29440037/persistent-inflammation-stem-cell-induced-systemic-anti-inflammatory-effects-and-need-for-repeated-stem-cell-injections-critical-concepts-influencing-optimal-stem-cell-strategies-for-treating-acute-myocardial-infarction-and-heart-failure
#14
EDITORIAL
Stephen E Epstein, Michael J Lipinski, Dror Luger
No abstract text is available yet for this article.
February 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29440036/repeated-administrations-of-cardiac-progenitor-cells-are-superior-to-a-single-administration-of-an-equivalent-cumulative-dose
#15
Xian-Liang Tang, Shunichi Nakamura, Qianhong Li, Marcin Wysoczynski, Anna M Gumpert, Wen-Jian Wu, Greg Hunt, Heather Stowers, Qinghui Ou, Roberto Bolli
BACKGROUND: We have recently found that 3 repeated doses (12×10 6 each) of c-kit POS cardiac progenitor cells (CPCs) were markedly more effective than a single dose of 12×10 6 cells in alleviating postinfarction left ventricular dysfunction and remodeling. However, since the single-dose group received only one third of the total number of CPCs given to the multiple-dose group, it is unknown whether the superior therapeutic efficacy was caused by repeated treatments per se or by administration of a higher total number of CPCs...
February 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29440035/readmissions-following-a-hospitalization-for-cardiovascular-events-in-dialysis-patients-a-retrospective-cohort-study
#16
James B Wetmore, Julia T Molony, Jiannong Liu, Yi Peng, Charles A Herzog, Allan J Collins, David T Gilbertson
BACKGROUND: Hospitalization for cardiovascular disease (CVD) is common among patients receiving maintenance dialysis, but patterns of readmissions following cardiovascular events are underexplored. METHODS AND RESULTS: In this retrospective analysis of prevalent, Medicare-eligible patients receiving dialysis in 2012-2013, all live-discharge hospitalizations attributed to CVD were ascertained. Rates of all-cause, CVD-related, and non-CVD-related readmissions and death in the ensuing 10 and 30 days were calculated...
February 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29440034/subclinical-compromise-in-cardiac-strain-relates-to-lower-cognitive-performances-in-older-adults
#17
Hailey A Kresge, Omair A Khan, Madison A Wagener, Dandan Liu, James G Terry, Sangeeta Nair, Francis E Cambronero, Katherine A Gifford, Katie E Osborn, Timothy J Hohman, Kimberly R Pechman, Susan P Bell, Thomas J Wang, John Jeffrey Carr, Angela L Jefferson
BACKGROUND: Global longitudinal strain (GLS), reflecting total shortening of the myocardium during the cardiac cycle, has emerged as a more precise myocardial function measure than left ventricular ejection fraction (LVEF). Longitudinal strain may be selectively affected in subclinical heart disease, even in the presence of normal LVEF. This study examines subclinical cardiac dysfunction, assessed by GLS and LVEF, and cognition among older adults. METHODS AND RESULTS: Vanderbilt Memory and Aging Project participants who were free of clinical dementia, stroke, and heart failure (n=318, 73±7 years, 58% male) completed neuropsychological assessment and cardiac magnetic resonance to quantify GLS and LVEF...
February 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29440033/trajectories-of-long-term-normal-fasting-plasma-glucose-and-risk-of-coronary-heart-disease-a-prospective-cohort-study
#18
Zhongshang Yuan, Yang Yang, Chunxia Wang, Jing Liu, Xiubin Sun, Yi Liu, Shengxu Li, Fuzhong Xue
BACKGROUND: Fasting plasma glucose (FPG) levels can vary over time and its longitudinal changing patterns may predict cardiometabolic risk. We aim to identify different trajectories of FPG in those who remained normoglycemic and investigate the association between trajectory groups and coronary heart disease risk in a large prospective cohort study. METHODS AND RESULTS: A total of 20 514 subjects between ages 20 and 80 years were included at baseline. All participants had maintained normal FPG throughout an average follow-up period of 5...
February 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29440011/different-weight-histories-and-risk-of-incident-coronary-heart-disease-and-stroke-tehran-lipid-and-glucose-study
#19
Maryam Kabootari, Samaneh Asgari, Mohammad Ali Mansournia, Davood Khalili, Majid Valizadeh, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND: This study aimed to determine the association between different weight histories, including cumulative excess weight, cumulative excess waist circumference (WC), duration of general and central adiposity, current and maximum body mass index, and current and maximum WC, and incident coronary heart disease (CHD) and stroke. METHODS AND RESULTS: The study population consisted of 4398 adults aged ≥40 years without CHD or stroke at baseline. Associations between different weight histories and CHD and stroke were determined by multivariable time-varying Cox regression models after adjustment for age, sex, and time-varying confounders...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29440010/effect-and-safety-of-morphine-use-in-acute-anterior-st-segment-elevation-myocardial-infarction
#20
Mickael Bonin, Nathan Mewton, Francois Roubille, Olivier Morel, Guillaume Cayla, Denis Angoulvant, Meyer Elbaz, Marc J Claeys, David Garcia-Dorado, Céline Giraud, Gilles Rioufol, Claire Jossan, Michel Ovize, Patrice Guerin
BACKGROUND: Morphine is commonly used to treat chest pain during myocardial infarction, but its effect on cardiovascular outcome has never been directly evaluated. The aim of this study was to examine the effect and safety of morphine in patients with acute anterior ST-segment elevation myocardial infarction followed up for 1 year. METHODS AND RESULTS: We used the database of the CIRCUS (Does Cyclosporine Improve Outcome in ST Elevation Myocardial Infarction Patients) trial, which included 969 patients with anterior ST-segment elevation myocardial infarction, admitted for primary percutaneous coronary intervention...
February 10, 2018: Journal of the American Heart Association
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