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Journal of the American Heart Association

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https://www.readbyqxmd.com/read/29233827/stress-echocardiography-positivity-predicts-cancer-death
#1
Clara Carpeggiani, Patrizia Landi, Claudio Michelassi, Maria Grazia Andreassi, Rosa Sicari, Eugenio Picano
BACKGROUND: Stress echocardiography (SE) predicts cardiac death, but an increasing share of cardiac patients eventually die of cancer. The aim of the study was to assess whether SE positivity predicts cancer death. METHODS AND RESULTS: In a retrospective analysis of prospectively acquired single-center, observational data, we evaluated 4673 consecutive patients who underwent SE from 1983 to 2009. All patients were cancer-free at index SE and were followed up for a median of 131 months (interquartile range 134)...
December 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29233826/association-of-atrial-fibrillation-and-oral-anticoagulant-use-with-perioperative-outcomes-after-major-noncardiac-surgery
#2
Yin Ge, Andrew C T Ha, Clare L Atzema, Husam M Abdel-Qadir, Jiming Fang, Peter C Austin, Duminda N Wijeysundera, Douglas S Lee
BACKGROUND: We examined the association of atrial fibrillation (AF) and oral anticoagulant use with perioperative death and bleeding among patients undergoing major noncardiac surgery. METHODS AND RESULTS: A population-based study of patients aged 66 years and older who underwent elective (n=87 257) or urgent (n=35 930) noncardiac surgery in Ontario, Canada (April 2012 to March 2015) was performed. Outcomes were compared between AF groups using inverse probability of treatment weighting using the propensity score...
December 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223957/prognostic-utility-of-morning-blood-pressure-surge-for-20-year-all-cause-and-cardiovascular-mortalities-results-of-a-community-based-study
#3
Hao-Min Cheng, Chung-Li Wu, Shih-Hsien Sung, Jia-Chun Lee, Kazuomi Kario, Chern-En Chiang, Chi-Jung Huang, Pai-Feng Hsu, Shao-Yuan Chuang, Edward G Lakatta, Frank C P Yin, Pesus Chou, Chen-Huan Chen
BACKGROUND: Morning blood pressure (BP) surge (MS), defined by the MS amplitude, is an independent prognostic factor of cardiovascular outcomes in some, but not all, populations. METHOD AND RESULTS: We enrolled 2020 participants (1029 men; aged 30-79 years) with 24-hour ambulatory BP data. During a median 19.7-year follow-up, 607 deaths (182 by cardiovascular causes) were confirmed from the National Death Registry. The amplitude of sleep-trough MS (STMS) was derived from the difference between morning systolic BP (SBP) and lowest nighttime SBP...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223956/residual-risk-of-atherosclerotic-cardiovascular-events-in-relation-to-reductions-in-very-low-density-lipoproteins
#4
Patrick R Lawler, Akintunde O Akinkuolie, Paulo Harada, Robert J Glynn, Daniel I Chasman, Paul M Ridker, Samia Mora
BACKGROUND: It is uncertain whether pharmacological reductions in very-low-density lipoproteins (VLDLs), and their component triglyceride and cholesterol could reduce residual risk of atherosclerotic cardiovascular disease (ASCVD) events among individuals in whom low-density lipoprotein cholesterol (LDL-C) has been adequately lowered. We examined whether individuals with greater on-statin reductions in VLDL-related measures-beyond reductions in LDL-C-were at further reduced risk of ASCVD...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223955/high-density-lipoprotein-cholesterol-concentration-and-acute-kidney-injury-after-cardiac-surgery
#5
Loren E Smith, Derek K Smith, Jeffrey D Blume, MacRae F Linton, Frederic T Billings
BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is associated with increased short- and long-term mortality. Inflammation, oxidative stress, and endothelial dysfunction and damage play important roles in the development of AKI. High-density lipoproteins (HDLs) have anti-inflammatory and antioxidant properties and improve endothelial function and repair. Statins enhance HDL's anti-inflammatory and antioxidant capacities. We hypothesized that a higher preoperative HDL cholesterol concentration is associated with decreased AKI after cardiac surgery and that perioperative statin exposure potentiates this association...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223954/effect-of-pcsk9-inhibitors-on-clinical-outcomes-in-patients-with-hypercholesterolemia-a-meta-analysis-of-35-randomized-controlled-trials
#6
REVIEW
Aris Karatasakis, Barbara A Danek, Judit Karacsonyi, Bavana V Rangan, Michele K Roesle, Thomas Knickelbine, Michael D Miedema, Houman Khalili, Zahid Ahmad, Shuaib Abdullah, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: We sought to examine the efficacy and safety of 2 PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors: alirocumab and evolocumab. METHODS AND RESULTS: We performed a systematic review and meta-analysis of randomized controlled trials comparing treatment with and without PCSK9 inhibitors; 35 randomized controlled trials comprising 45 539 patients (mean follow-up: 85.5 weeks) were included. Mean age was 61.0±2.8 years, and mean baseline low-density lipoprotein cholesterol was 106±22 mg/dL...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29222390/sodium-channel-remodeling-in-subcellular-microdomains-of-murine-failing-cardiomyocytes
#7
Mathilde R Rivaud, Esperanza Agullo-Pascual, Xianming Lin, Alejandra Leo-Macias, Mingliang Zhang, Eli Rothenberg, Connie R Bezzina, Mario Delmar, Carol Ann Remme
BACKGROUND: Cardiac sodium channel (NaV1.5) dysfunction contributes to arrhythmogenesis during pathophysiological conditions. Nav1.5 localizes to distinct subcellular microdomains within the cardiomyocyte, where it associates with region-specific proteins, yielding complexes whose function is location specific. We herein investigated sodium channel remodeling within distinct cardiomyocyte microdomains during heart failure. METHODS AND RESULTS: Mice were subjected to 6 weeks of transverse aortic constriction (TAC; n=32) to induce heart failure...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29217664/incidence-diagnosis-and-management-of-qt-prolongation-induced-by-cancer-therapies-a-systematic-review
#8
REVIEW
Andreu Porta-Sánchez, Cameron Gilbert, Danna Spears, Eitan Amir, Joyce Chan, Kumaraswamy Nanthakumar, Paaladinesh Thavendiranathan
BACKGROUND: The cardiovascular complications of cancer therapeutics are the focus of the burgeoning field of cardio-oncology. A common challenge in this field is the impact of cancer drugs on cardiac repolarization (ie, QT prolongation) and the potential risk for the life-threatening arrhythmia torsades de pointes. Although QT prolongation is not a perfect marker of arrhythmia risk, this has become a primary safety metric among oncologists. Cardiologists caring for patients receiving cancer treatment should become familiar with the drugs associated with QT prolongation, its incidence, and appropriate management strategies to provide meaningful consultation in this complex clinical scenario...
December 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29217663/prevalence-and-clinical-characteristics-of-refractory-hypertension
#9
Pedro Armario, David A Calhoun, Anna Oliveras, Pedro Blanch, Ernest Vinyoles, Jose R Banegas, Manuel Gorostidi, Julián Segura, Luis M Ruilope, Tanja Dudenbostel, Alejandro de la Sierra
BACKGROUND: We aimed to estimate the prevalence of refractory hypertension (RfH) and to determine the clinical differences between these patients and resistant hypertensives (RH). Secondly, we assessed the prevalence of white-coat RfH and clinical differences between true- and white-coat RfH patients. METHODS AND RESULTS: The present analysis was conducted on the Spanish Ambulatory Blood Pressure Monitoring Registry database containing 70 997 treated hypertensive patients...
December 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29217662/long-term-prognostic-implications-of-cerebral-microbleeds-in-chinese-patients-with-ischemic-stroke
#10
Kui Kai Lau, Yuen Kwun Wong, Kay Cheong Teo, Richard S K Chang, Man Yu Tse, Chu Peng Hoi, Chung Yan Chan, Oi Ling Chan, Ryan Hoi Kit Cheung, Edmund Ka Ming Wong, Joseph Shiu Kwong Kwan, Edward S Hui, Henry Ka Fung Mak
BACKGROUND: This study was performed to determine the clinical correlates and long-term prognostic implications of microbleed burden and location in Chinese patients with ischemic stroke. METHODS AND RESULTS: We recruited 1003 predominantly Chinese patients with ischemic stroke who received magnetic resonance imaging at the University of Hong Kong. We determined the clinical correlates of microbleeds and the long-term risks (3126 patient-years of follow-up) of recurrent ischemic stroke and intracerebral hemorrhage (ICH) by microbleed burden (0 versus 1, 2-4, and ≥5) and location, adjusting for age, sex, and vascular risk factors and stratified by antithrombotic use...
December 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29212651/relation-between-blood-pressure-and-clinical-outcome-in-hypertensive-subjects-with-previous-stroke
#11
Chan Joo Lee, Jinseub Hwang, Jaewon Oh, Sang-Hak Lee, Seok-Min Kang, Hyeon Chang Kim, Sungha Park
BACKGROUND: This study investigated whether a mean blood pressure (BP) of <130/80 mm Hg is associated with further reduction in cardiovascular outcomes in treated hypertensive subjects with previous stroke. METHODS AND RESULTS: Subjects from the Korea National Health Insurance Service health examinee cohort diagnosed as having stroke and hypertension from January 1st, 2003 and December 31st, 2006 (N=2320) were grouped according to mean systolic (<130, 130-<140, and ≥140 mm Hg) and diastolic (<80, 80-<90, and ≥90 mm Hg) BP recorded during follow-up health examinations...
December 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29212650/low-nasal-no-in-congenital-heart-disease-with-systemic-right-ventricle-and-postcardiac-transplantation
#12
Phillip S Adams, Maliha Zahid, Omar Khalifa, Brian Feingold, Cecilia W Lo
BACKGROUND: NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association of NO bioavailability with heart failure risk, we hypothesized NO levels may differ with varying severity of CHD physiologic characteristics. METHODS AND RESULTS: Six-hundred eighteen subjects, 483 with CHD and 135 controls, had nNO measured noninvasively via the nares using American Thoracic Society/European Respiratory Society guidelines...
December 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29203581/cardiac-insulin-signaling-regulates-glycolysis-through-phosphofructokinase-2-content-and-activity
#13
Lee B Bockus, Satoshi Matsuzaki, Shraddha S Vadvalkar, Zachary T Young, Jennifer R Giorgione, Maria F Newhardt, Michael Kinter, Kenneth M Humphries
BACKGROUND: The healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Diabetes mellitus disrupts this metabolic flexibility and promotes cardiomyopathy through mechanisms that are not completely understood. Phosphofructokinase 2 (PFK-2) is a primary regulator of cardiac glycolysis and substrate selection, yet its regulation under normal and pathological conditions is unknown. This study was undertaken to determine how changes in insulin signaling affect PFK-2 content, activity, and cardiac metabolism...
December 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29203580/thrombocytopenia-as-a-preoperative-risk-assessment-tool-in-patients-with-rheumatic-heart-disease-undergoing-valve-replacement-surgery
#14
Xue-Biao Wei, Lei Jiang, Yuan-Hui Liu, Du Feng, Peng-Cheng He, Ji-Yan Chen, Ning Tan, Dan-Qing Yu
BACKGROUND: Postoperative thrombocytopenia has been reported to be correlated with adverse events, but the prognostic value of baseline thrombocytopenia is unclear. This study was undertaken to evaluate the relationship between preoperative thrombocytopenia and adverse outcomes in patients with rheumatic heart disease who underwent valve replacement surgery. METHODS AND RESULTS: A total of 1789 patients with rheumatic heart disease undergoing valve replacement surgery were consecutively enrolled and postoperatively followed up for 1 year...
December 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29203579/heads-and-tails-of-natriuretic-peptides-neuroprotective-role-of-brain-natriuretic-peptide
#15
Héctor Fernández-Susavila, Manuel Rodríguez-Yáñez, Antonio Dopico-López, Susana Arias, María Santamaría, Paulo Ávila-Gómez, Juan M Doval-García, Tomás Sobrino, Ramón Iglesias-Rey, José Castillo, Francisco Campos
BACKGROUND: Besides the relevant role of brain-type natriuretic peptide (BNP) as biomarker of cardioembolic strokes, new experimental evidences suggest that this peptide may mediate neuroprotective effects. In this study, we have evaluated for the first time the clinical association between BNP (by means of proBNP) and good outcome in ischemic stroke patients, and analyzed the effect of blood BNP increase in an ischemic animal model. METHODS AND RESULTS: A retrospective study with 2 different cohorts (262 patients in cohort I and 610 in cohort II) from the same prospective stroke registry was performed...
December 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29203578/left-ventricular-thrombi-in-takotsubo-syndrome-incidence-predictors-and-management-results-from-the-geist-german-italian-stress-cardiomyopathy-registry
#16
Francesco Santoro, Thomas Stiermaier, Nicola Tarantino, Luisa De Gennaro, Christian Moeller, Francesca Guastafierro, Maria Francesca Marchetti, Roberta Montisci, Elena Carapelle, Tobias Graf, Pasquale Caldarola, Holger Thiele, Matteo Di Biase, Natale Daniele Brunetti, Ingo Eitel
BACKGROUND: Left ventricular (LV) thrombi during Takotsubo syndrome represent a potential complication and can be associated with cerebrovascular embolic events. The aim of this study was to evaluate the exact incidence, predictors, and management strategies of LV thrombi in patients with Takotsubo syndrome. METHODS AND RESULTS: We enrolled 541 consecutive patients in a multicenter international registry. Clinical features and echocardiographic data at admission, during hospitalization, and after 3 months were evaluated...
December 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29197832/comparison-of-deep-sedation-with-general-anesthesia-in-patients-undergoing-percutaneous-mitral-valve-repair
#17
Johannes Patzelt, Miriam Ulrich, Harry Magunia, Reinhard Sauter, Michal Droppa, Rezo Jorbenadze, Annika S Becker, Tobias Walker, Ralph Stephan von Bardeleben, Christian Grasshoff, Peter Rosenberger, Meinrad Gawaz, Peter Seizer, Harald F Langer
BACKGROUND: Percutaneous edge-to-edge mitral valve repair (PMVR) has become an established treatment option for mitral regurgitation in patients not eligible for surgical repair. Currently, most procedures are performed under general anesthesia (GA). An increasing number of centers, however, are performing the procedure under deep sedation (DS). Here, we compared patients undergoing PMVR with GA or DS. METHODS AND RESULTS: A total of 271 consecutive patients underwent PMVR at our institution between May 2014 and December 2016...
December 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29197831/association-between-smoking-and-serum-glyca-and-high-sensitivity-c-reactive-protein-levels-the-multi-ethnic-study-of-atherosclerosis-mesa-and-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#18
(no author information available yet)
No abstract text is available yet for this article.
December 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29197830/association-of-accelerometry-measured-physical-activity-and-cardiovascular-events-in-mobility-limited-older-adults-the-life-lifestyle-interventions-and-independence-for-elders-study
#19
Shannon K Cochrane, Shyh-Huei Chen, Jodi D Fitzgerald, John A Dodson, Roger A Fielding, Abby C King, Mary M McDermott, Todd M Manini, Anthony P Marsh, Anne B Newman, Marco Pahor, Catrine Tudor-Locke, Walter T Ambrosius, Thomas W Buford
BACKGROUND: Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. METHODS AND RESULTS: Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis...
December 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29197829/cadmium-carotid-atherosclerosis-and-incidence-of-ischemic-stroke
#20
Yan Borné, Björn Fagerberg, Margaretha Persson, Gerd Östling, Martin Söderholm, Bo Hedblad, Gerd Sallsten, Lars Barregard, Gunnar Engström
BACKGROUND: Exposure to cadmium has been associated with carotid plaques, inflammation in carotid plaques, and increased risk of ischemic stroke. This study examined the separate and interacting effects of blood cadmium levels and carotid plaques on the risk of incident ischemic stroke. METHODS AND RESULTS: Cadmium levels were measured in 4156 subjects (39.2% men; mean±SD age 57.3±5.9 years) without history of stroke, from the Malmö Diet and Cancer cohort. The right carotid artery was examined using B-mode ultrasound examination at baseline...
December 2, 2017: Journal of the American Heart Association
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