journal
MENU ▼
Read by QxMD icon Read
search

Journal of the American Heart Association

journal
https://www.readbyqxmd.com/read/27899365/prevalence-and-clinical-significance-of-discordant-changes-in-fractional-and-coronary-flow-reserve-after-elective-percutaneous-coronary-intervention
#1
Junji Matsuda, Tadashi Murai, Yoshihisa Kanaji, Eisuke Usui, Makoto Araki, Takayuki Niida, Sadamitsu Ichijyo, Rikuta Hamaya, Tetsumin Lee, Taishi Yonetsu, Mitsuaki Isobe, Tsunekazu Kakuta
BACKGROUND: Fractional flow reserve (FFR) and coronary flow reserve (CFR) are well-validated physiological indices; however, changes in FFR and CFR after percutaneous coronary intervention (PCI) remain elusive. We sought to evaluate these changes and to investigate whether physiological indices predict cardiac event-free survival after PCI. METHODS AND RESULTS: Physiological assessment of 220 stenoses from 220 patients was performed before and after PCI. The changes in FFR and CFR were studied, and factors associated with CFR change were investigated...
November 29, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27899364/identification-of-shared-and-unique-serum-lipid-profiles-in-diabetes-mellitus-and-myocardial-infarction
#2
Sanela Kjellqvist, Christian Klose, Michal A Surma, George Hindy, Inês G Mollet, Anna Johansson, Patrick Chavaux, Johan Gottfries, Kai Simons, Olle Melander, Céline Fernandez
BACKGROUND: Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. METHODS AND RESULTS: We used shotgun mass spectrometry to determine serum levels of 255 molecular lipids in 316 controls, 171 DM, and 99 myocardial infarction (MI) events from a cohort derived from the Malmö Diet and Cancer study. Orthogonal projections to latent structures analyses were conducted between the lipids and clinical parameters describing DM or MI...
November 29, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27895045/cardiorespiratory-fitness-and-highly-sensitive-cardiac-troponin-levels-in-a-preventive-medicine-cohort
#3
Laura F DeFina, Benjamin L Willis, Nina B Radford, Robert H Christenson, Christopher R deFilippi, James A de Lemos
BACKGROUND: Cardiorespiratory fitness (CRF) and highly sensitive cardiac troponin T (hs-cTnT) are associated with risk of all-cause and cardiovascular mortality as well as incident heart failure. A link of low CRF to subclinical cardiac injury may explain this association. We hypothesized that CRF would be inversely associated with hs-cTnT measured in healthy adults over age 50. METHODS AND RESULTS: We evaluated 2498 participants (24.7% female, mean age 58.7 years) from the Cooper Center Longitudinal Study between August 2008 and January 2012...
November 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27895044/polymorphisms-in-the-gnas-gene-as-predictors-of-ventricular-tachyarrhythmias-and-sudden-cardiac-death-results-from-the-discovery-trial-and-oregon-sudden-unexpected-death-study
#4
Heinrich Wieneke, Jesper Hastrup Svendsen, Jeffrey Lande, Sebastian Spencker, Juan Gabriel Martinez, Bernhard Strohmer, Lauri Toivonen, Hervé Le Marec, F Javier Garcia-Fernandez, Domenico Corrado, Adriana Huertas-Vazquez, Audrey Uy-Evanado, Carmen Rusinaru, Kyndaron Reinier, Csaba Foldesi, Wieslaw Hulak, Sumeet S Chugh, Winfried Siffert
BACKGROUND: Population-based studies suggest that genetic factors contribute to sudden cardiac death (SCD). METHODS AND RESULTS: In the first part of the present study (Diagnostic Data Influence on Disease Management and Relation of Genetic Polymorphisms to Ventricular Tachy-arrhythmia in ICD Patients [DISCOVERY] trial) Cox regression was done to determine if 7 single-nucleotide polymorphisms (SNPs) in 3 genes coding G-protein subunits (GNB3, GNAQ, GNAS) were associated with ventricular tachyarrhythmia (VT) in 1145 patients receiving an implantable cardioverter-defibrillator (ICD)...
November 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27895043/impact-of-alcohol-consumption-on-the-outcome-of-catheter-ablation-in-patients-with-paroxysmal-atrial-fibrillation
#5
Masateru Takigawa, Atsushi Takahashi, Taishi Kuwahara, Yoshihide Takahashi, Kenji Okubo, Emiko Nakashima, Yuji Watari, Jun Nakajima, Kazuya Yamao, Yuki Osaka, Yasuaki Tanaka, Shigeki Kimura, Katsumasa Takagi, Hiroyuki Hikita, Kenzo Hirao, Mitsuaki Isobe
BACKGROUND: Although several studies have reported an association between atrial fibrillation (AF) and alcohol, the impact of alcohol consumption on the outcome after catheter ablation (CA) for AF has not been discussed. We aimed to elucidate the effect of alcohol consumption on the outcome of CA for paroxysmal AF. METHODS AND RESULTS: We examined 1361 consecutive patients with paroxysmal AF (mean age, 61±11 years, 334 women) who underwent CA, including 623 (45...
November 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27895042/prognostic-value-of-cardiac-troponin-t-and-sex-in-patients-undergoing-elective-percutaneous-coronary-intervention
#6
Yukinori Harada, Jonathan Michel, Wolfgang Koenig, Tobias Rheude, Roisin Colleran, Daniele Giacoppo, Adnan Kastrati, Robert A Byrne
BACKGROUND: In patients with stable coronary artery disease undergoing elective percutaneous coronary intervention, the prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) and the influence of sex remain poorly defined. METHODS AND RESULTS: Consecutive patients with stable coronary artery disease who underwent elective percutaneous coronary intervention were included. Primary endpoint was all-cause mortality. Unadjusted hazard ratio (HR) in overall and sex-specific population and multivariable adjusted HR were calculated by using Cox proportional hazard models...
November 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881427/ischemic-stroke-rate-increases-in-young-adults-evidence-for-a-generational-effect
#7
Joel N Swerdel, George G Rhoads, Jerry Q Cheng, Nora M Cosgrove, Abel E Moreyra, John B Kostis, William J Kostis
BACKGROUND: The incidence rates of ischemic stroke and ST-segment elevation myocardial infarction (STEMI) have decreased significantly in the United States since 1950. However, there is evidence of flattening of this trend or increasing rates for stroke in patients younger than 50 years. The objective of this study was to examine the changes in incidence rates of stroke and STEMI using an age-period-cohort model with statewide data from New Jersey. METHODS AND RESULTS: We obtained stroke and STEMI data for the years 1995-2014 from the Myocardial Infarction Data Acquisition System, a database of hospital discharges in New Jersey...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881426/contemporary-trends-and-age-specific-sex-differences-in-management-and-outcome-for-patients-with-st-segment-elevation-myocardial-infarction
#8
Leonardo De Luca, Marco Marini, Lucio Gonzini, Alessandro Boccanelli, Gianni Casella, Francesco Chiarella, Stefano De Servi, Antonio Di Chiara, Giuseppe Di Pasquale, Zoran Olivari, Giorgio Caretta, Laura Lenatti, Michele Massimo Gulizia, Stefano Savonitto
BACKGROUND: Age- and sex-specific differences exist in the treatment and outcome of ST-elevation myocardial infarction (STEMI). We sought to describe age- and sex-matched contemporary trends of in-hospital management and outcome of patients with STEMI. METHODS AND RESULTS: We analyzed data from 5 Italian nationwide prospective registries, conducted between 2001 and 2014, including consecutive patients with STEMI. All the analyses were age- and sex-matched, considering 4 age classes: <55, 55 to 64, 65 to 74, and ≥75 years...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881425/relationship-between-language-preference-and-intravenous-thrombolysis-among-acute-ischemic-stroke-patients
#9
Betty Luan Erfe, Khawja Ahmeruddin Siddiqui, Lee H Schwamm, Nicte I Mejia
BACKGROUND: Approximately 20% of the US population primarily speaks a language other than English at home. Yet the effect of language preference on treatment of acute ischemic stroke (AIS) patients remains unknown. We aimed to evaluate the influence of language preference on AIS patients' receipt of intravenous (IV) thrombolysis. METHODS AND RESULTS: We analyzed data from 3894 AIS patients who participated in the American Heart Association "Get With The Guidelines(®)-Stroke" program at our hospital from January 1, 2003 to April 30, 2014...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881424/temporal-reduction-in-chronotropic-index-predicts-risk-of-cardiovascular-death-among-healthy-middle-aged-men-a-28-year-follow-up-study
#10
Kristian Engeseth, Christian Hodnesdal, Irene Grundvold, Knut Liestøl, Knut Gjesdal, Sverre E Kjeldsen, Jan E Erikssen, Johan Bodegard, Per Torger Skretteberg
BACKGROUND: Chronotropic index is a standardized measure of heart rate (HR) increment during exercise that reflects the combined effects of age, resting HR, and physical fitness. Low chronotropic index has been reported to predict disease and death. We tested whether temporal change in chronotropic index over 7 years influenced risk of cardiovascular death through up to 28 years. METHODS AND RESULTS: Chronotropic index was calculated ([achieved maximal HR-resting HR]/[age-predicted maximal HR-resting HR]) after a symptom-limited bicycle ECG exercise test in 1420 healthy men at 2 examinations 7 years apart, in 1972 and 1979...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881423/association-of-systemic-arterial-properties-with-right-ventricular-morphology-the-multi-ethnic-study-of-atherosclerosis-mesa-right-ventricle-study
#11
Nadine Al-Naamani, Julio A Chirinos, Payman Zamani, Robin Ruthazer, Jessica K Paulus, Kari E Roberts, R Graham Barr, Joao A Lima, David A Bluemke, Richard Kronmal, Steven M Kawut
BACKGROUND: Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown. METHODS AND RESULTS: The associations between systemic arterial measures (total arterial compliance [TAC], systemic vascular resistance [SVR], and aortic augmentation index [AI]) and RV morphology (mass, end-systolic [RVESV] and end-diastolic volume [RVEDV], and ejection fraction [RVEF]) were examined using data from the Multi-Ethnic Study of Atherosclerosis...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881422/association-of-cholesterol-efflux-capacity-with-clinical-features-of-metabolic-syndrome-relevance-to-atherosclerosis
#12
Julie Gall, Eric Frisdal, Randa Bittar, Wilfried Le Goff, Eric Bruckert, Philippe Lesnik, Maryse Guerin, Philippe Giral
BACKGROUND: The contribution of high-density lipoprotein to cardiovascular benefit is closely linked to its role in the cellular cholesterol efflux process; however, various clinical and biochemical variables are known to modulate the overall cholesterol efflux process. The aim of this study was to evaluate the extent to which clinical and biological anomalies associated with the establishment of the metabolic syndrome modulate cholesterol efflux capacity and contribute to development of atherosclerosis...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881421/common-variant-in-glycoprotein-ia-increases-long-term-adverse-events-risk-after-coronary-artery-bypass-graft-surgery
#13
Hanning Liu, Zhengxi Xu, Haiyong Gu, Wenke Li, Wen Chen, Cheng Sun, Kun Zhao, Xiao Teng, Heng Zhang, Lixin Jiang, Shengshou Hu, Zhou Zhou, Zhe Zheng
BACKGROUND: This study was aimed to investigate the clinical relevance between glycoprotein Ia (GPIA) rs1126643C/T polymorphism and the outcome of coronary artery disease after coronary artery bypass graft (CABG) surgery and explore the involved potential mechanisms. METHODS AND RESULTS: We genotyped GPIA rs1126643 polymorphism of 1592 patients who underwent CABG and followed up for a median period of 72.8 months. Patients who are GPIA rs1126643 T-allele carriers have a higher major adverse cardiac or cerebrovascular events risk post-CABG than those who are CC homozygotes (hazard ratio [HR]=1...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881420/elongation-of-long-chain-fatty-acid-family-member-6-elovl6-driven-fatty-acid-metabolism-regulates-vascular-smooth-muscle-cell-phenotype-through-amp-activated-protein-kinase-kr%C3%A3-ppel-like-factor-4-ampk-klf4-signaling
#14
Hiroaki Sunaga, Hiroki Matsui, Saki Anjo, Mas Risky A A Syamsunarno, Norimichi Koitabashi, Tatsuya Iso, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi
BACKGROUND: Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has been lacking. We investigated the role of elongation of long-chain fatty acid member 6 (Elovl6), a rate-limiting enzyme catalyzing the elongation of saturated and monounsaturated long-chain fatty acid, in the regulation of phenotypic switching of VSMC...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27866165/anemia-and-acute-coronary-syndrome-time-for-intervention-studies
#15
EDITORIAL
Serdar Farhan, Usman Baber, Roxana Mehran
No abstract text is available yet for this article.
November 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27866164/relationship-between-anemia-and-mortality-outcomes-in-a-national-acute-coronary-syndrome-cohort-insights-from-the-uk-myocardial-ischemia-national-audit-project-registry
#16
Mamas A Mamas, Chun Shing Kwok, Evangelos Kontopantelis, Anthony A Fryer, Iain Buchan, Max O Bachmann, M Justin Zaman, Phyo K Myint
BACKGROUND: We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. METHODS AND RESULTS: The Myocardial Ischemia National Audit Project (MINAP) registry collects data on all adults admitted to hospital trusts in England and Wales with diagnosis of an ACS. We conducted a retrospective cohort study by analyzing patients in this registry between January 2006 and December 2010 and followed them up until August 2011...
November 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27866163/prognosis-in-familial-atrial-fibrillation
#17
EDITORIAL
Laurent Fauchier, Arnaud Bisson, Nicolas Clementy
No abstract text is available yet for this article.
November 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27866162/outcomes-associated-with-familial-versus-nonfamilial-atrial-fibrillation-a-matched-nationwide-cohort-study
#18
Anna Gundlund, Jonas Bjerring Olesen, Laila Staerk, Christina Lee, Jonathan P Piccini, Eric D Peterson, Lars Køber, Christian Torp-Pedersen, Gunnar H Gislason, Emil Loldrup Fosbøl
BACKGROUND: We examined all-cause mortality and long-term thromboembolic risk (ischemic stroke, transient ischemic attack, systemic thromboembolism) in patients with and without familial atrial fibrillation (AF). METHODS AND RESULTS: Using Danish nationwide registry data, we identified all patients diagnosed with AF (1995-2012) and divided them into those with familial AF (having a first-degree family member with a prior AF admission) and those with nonfamilial AF...
November 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27856487/repositionable-versus-balloon-expandable-devices-for-transcatheter-aortic-valve-implantation-in-patients-with-aortic-stenosis
#19
Thomas Pilgrim, Stefan Stortecky, Fabian Nietlispach, Dik Heg, David Tueller, Stefan Toggweiler, Enrico Ferrari, Stéphane Noble, Francesco Maisano, Raban Jeger, Marco Roffi, Jürg Grünenfelder, Christoph Huber, Peter Wenaweser, Stephan Windecker
BACKGROUND: The safety and effectiveness of the fully repositionable LOTUS valve system as compared with the balloon-expandable Edwards SAPIEN 3 prosthesis for the treatment of aortic stenosis has not been evaluated to date. METHODS AND RESULTS: All patients undergoing transcatheter aortic valve implantation with the Edwards SAPIEN 3 or the LOTUS valve system were included into the Swiss Transcatheter Aortic Valve Implantation Registry. An adjusted analysis was performed to compare the early clinical safety outcome according to the Valve Academic Research Consortium-2 definition...
November 17, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27856486/myocardial-immunocompetent-cells-and-macrophage-phenotypes-as%C3%A2-histopathological-surrogates-for-diagnosis-of-cardiac-sarcoidosis-in-japanese
#20
Yasuyuki Honda, Toshiyuki Nagai, Yoshihiko Ikeda, Mamoru Sakakibara, Naoya Asakawa, Nobutaka Nagano, Michikazu Nakai, Kunihiro Nishimura, Yasuo Sugano, Keiko Ohta-Ogo, Yasuhide Asaumi, Takeshi Aiba, Hideaki Kanzaki, Kengo Kusano, Teruo Noguchi, Satoshi Yasuda, Hiroyuki Tsutsui, Hatsue Ishibashi-Ueda, Toshihisa Anzai
BACKGROUND: The histological diagnosis of cardiac sarcoidosis (CS) is based on the presence of myocardial granulomas; however, the sensitivity of endomyocardial biopsy is relatively low. We investigated whether immunocompetent cells including dendritic cells (DC) and macrophages in nongranuloma sections of endomyocardial biopsy samples could be histopathological surrogates for CS diagnosis. METHODS AND RESULTS: The numbers of DC and macrophages were investigated in 95 consecutive CS patients and 50 patients with nonischemic cardiomyopathy as controls...
November 17, 2016: Journal of the American Heart Association
journal
journal
43995
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"