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Multiple Sclerosis and related Disorders

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https://www.readbyqxmd.com/read/27919509/editors-welcome
#1
EDITORIAL
Chris Hawkes, Fred Lublin, Gavin Giovannoni, Emmanuelle Waubant
No abstract text is available yet for this article.
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919508/the-evaluation-of-mri-diffusion-values-of-active-demyelinating-lesions-in-multiple-sclerosis
#2
Mohammad Abdoli, Santanu Chakraborty, Heather J MacLean, Mark S Freedman
BACKGROUND: Gadolinium (Gd) enhancement of lesions is the main radiologic marker for detection of activity in Multiple Sclerosis (MS). This study compares Diffusion weighted imaging (DWI) characteristics and enhancement to determine whether DWI can be used as an alternative to Gd administration. METHODS: A retrospective study of 72 patients who had MRI with Gd and DWI. Visual assessment and comparison of the Apparent Diffusion Coefficient (ADC) values on Gd+ lesions, all lesions showing restricted diffusion, 2 Gd- lesions and 1 area of normal-appearing white matter (NAWM) in each MRI were performed...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919507/predictors-of-long-term-interferon-discontinuation-in-newly-diagnosed-relapsing-multiple-sclerosis
#3
Marcello Moccia, Raffaele Palladino, Antonio Carotenuto, Cinzia Valeria Russo, Maria Triassi, Roberta Lanzillo, Vincenzo Brescia Morra
BACKGROUND: Interferon-β has long-term safety and efficacy profiles for Relapsing Remitting Multiple Sclerosis (RRMS). However, the increasing number of available treatments requires to improve patient profiling and to perform individualized clinical decisions. Therefore, the present study investigated predictors of Interferon-β discontinuation. METHODS: The present retrospective observational cohort study included 499 newly diagnosed, drug naïve RRMS subjects receiving Interferon-β as first disease modifying treatment (DMT), during a 7...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919506/heart-rate-variability-predicts-the-magnitude-of-heart-rate-decrease-after-fingolimod-initiation
#4
Sakari Simula, Tomi P Laitinen, Tiina M Laitinen, Päivi Hartikainen, Juha Ek Hartikainen
BACKGROUND: Fingolimod is an immunomodulator with a disease modifying effect on relapsing-remitting multiple sclerosis (RRMS). A heart rate (HR) decrease shortly after fingolimod initiation, however, requires a clinical vigilance. The aim of this study was to prospectively investigate whether cardiac autonomic regulation can predict the magnitude of HR decrease after fingolimod initiation. METHODS: Twenty-five patients with RRMS underwent ambulatory 24-h electrocardiogram recording to assess HR variability 20±16 days before fingolimod initiation (baseline) and repeated at the day of fingolimod initiation to assess the magnitude of HR decrease...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919505/persian-adaptation-of-a-questionnaire-of-environmental-risk-factors-in-multiple-sclerosis-envims-q
#5
Mohammad Ali Sahraian, Hoda Naghshineh, Mohsen Shati, Soodeh Razeghi Jahromi, Niloofar Rezaei
BACKGROUND: It seems that gene-environment interaction play most important role in Multiple Sclerosis development. Increasing the incidence and prevalence of MS during the recent decades in the low prevalence area such as Iran is explained better by environment factors. Environmental Risk Factors in Multiple Sclerosis (the 'EnvIMS-Q') is a 6-page self-administered questionnaire for case control studies. OBJECTIVES: the objectives of study are validation and adaptation of the EnvIMS-Q' then development of a Persian version for case control studies in Persian population...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919504/successful-treatment-of-paroxysmal-ataxia-and-dysarthria-in-multiple-sclerosis-with-levetiracetam
#6
Shikha J Goodwin, Adam F Carpenter
BACKGROUND: Paroxysmal ataxia and dysarthria (PAD) is a relatively rare symptom in Multiple Sclerosis patients. PAD involves transient dysfunction in control, coordination and initiation of speech and/or limb movements. OBJECTIVE: To describe the successful use of levetiracetam for the treatment of PAD. METHODS: Case report. RESULTS: A 37-year-old woman with MS developed PAD approximately 3 months after a multifocal MS relapse...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919503/binocular-low-contrast-letter-acuity-and-the-symbol-digit-modalities-test-improve-the-ability-of-the-multiple-sclerosis-functional-composite-to-predict-disease-in-pediatric-multiple-sclerosis
#7
Amy T Waldman, Salim Chahin, Amy M Lavery, Geraldine Liu, Brenda L Banwell, Grant T Liu, Laura J Balcer
BACKGROUND: Outcome measures to capture disability, such as the Multiple Sclerosis Functional Composite (MSFC), were developed to enhance outcome measurements for clinical trials in adults with multiple sclerosis (MS). The MSFC initially included three components: a timed 25-foot walk [T25FW], 9-hole peg test [9HPT], and the Paced Auditory Serial Addition Task [PASAT]. Modifications to the original MSFC, such as adding binocular low-contrast letter acuity (LCLA) or substituting the symbol digit modalities test (SDMT) for the PASAT, improved the capacity to capture neurologic impairment in adults...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919502/motor-fatigability-after-low-intensity-hand-grip-exercises-in-persons-with-multiple-sclerosis
#8
Deborah Severijns, Mieke Lemmens, Ronald Thoelen, Peter Feys
INTRODUCTION: During maximal, sustained contractions, persons with multiple sclerosis (PwMS) show higher motor fatigability in comparison with healthy persons. It is not known if motor fatigability is also different between PwMS and healthy persons during low-intensity exercises. Thus, the aim of this study was to determine the difference in hand grip fatigability between healthy persons and PwMS for both hands during low-intensity hand grip exercises. METHODS: 19 PwMS and 19 healthy controls performed 18min of hand grip exercises at a maximum of 25% of the maximal voluntary strength, with an electronic hand dynamometer...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919501/soluble-serum-vcam-1-whole-blood-mrna-expression-and-treatment-response-in-natalizumab-treated-multiple-sclerosis
#9
E R Petersen, H B Søndergaard, A B Oturai, Peh Jensen, P S Sorensen, F Sellebjerg, L Börnsen
BACKGROUND: Natalizumab reduces disease activity in multiple sclerosis (MS). Natalizumab binds to the very late antigen-4 and inhibits vascular cell adhesion molecule-1 (VCAM-1)-mediated transmigration of immune cells across the blood-brain-barrier. This is associated with decreased serum concentrations of soluble (s)VCAM-1 and an altered composition of immune cell-subsets in the blood. OBJECTIVE: We aimed to examine if sVCAM-1 serum concentrations and whole blood mRNA expression levels of immune activation biomarkers is associated with disease activity in natalizumab-treated MS-patients...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919500/favorable-outcome-of-interferon-beta-associated-thrombotic-microangiopathy-following-treatment-with-corticosteroids-plasma-exchange-and-rituximab-a-case-report
#10
Lea M Gerischer, Eberhard Siebert, Oliver Janke, Gerhard Jan Jungehuelsing, Klemens Ruprecht
Thrombotic microangiopathy (TMA) is a rare but increasingly recognized complication of interferon-beta therapy, which can be associated with serious sequelae. We report on a 53-year-old woman with a longstanding history of relapsing-remitting multiple sclerosis, who developed TMA after 15 years of high-dose treatment with subcutaneous interferon-beta-1a. The patient presented with headaches, an epileptic seizure, confusion, and arterial hypertension. Laboratory findings included thrombocytopenia and hemolytic anemia...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919499/quality-of-life-and-its-correlates-in-adolescent-multiple-sclerosis-patients
#11
Slavica Ostojic, Dejan Stevanovic, Jasna Jancic
INTRODUCTION: Measures of health-related quality of life (HRQOL) are considered to be more comprehensive in health outcome assessments than scales assessing only the degree of neurological deficit. OBJECTIVE: The aim of the study was to evaluate HRQOL and its correlates among adolescents with multiple sclerosis (MS) in Serbia. METHODS: Demographic, clinical, and patient-reported outcome data were collected for 21 adolescents with MS, aged 14-18 years...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919498/association-between-exposure-to-farm-animals-and-pets-and-risk-of-multiple-sclerosis
#12
Dylan Siejka, Bruce Taylor, Anne-Louise Ponsonby, Terence Dwyer, Ingrid van der Mei
PURPOSE: There exists inconsistent evidence regarding animals including pets as risk factors for the development of Multiple Sclerosis (MS). We investigated the association between farm animals and pets as possible environmental factors in MS development. METHODS: Population based case-control study with 136 clinically definite MS cases and 272 controls randomly chosen from the community matched on sex and age. Data was collected from both questionnaire and a lifetime calendar detailing residence, occupation and pet/animal exposure over the course of participant's lives...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919497/comparative-efficacy-and-discontinuation-of-dimethyl-fumarate-and-fingolimod-in-clinical-practice-at-12-month-follow-up
#13
Carrie M Hersh, Thomas E Love, Samuel Cohn, Claire Hara-Cleaver, Robert A Bermel, Robert J Fox, Jeffrey A Cohen, Daniel Ontaneda
BACKGROUND: Dimethyl fumarate (DMF) and fingolimod (FTY) are approved oral disease modifying therapies (DMT) for relapsing multiple sclerosis (MS). Phase 3 trials established these agents as effective and generally well tolerated, though comparative efficacy and discontinuation remain unknown. OBJECTIVE: To assess real-world efficacy and discontinuation of DMF and FTY over 12 months in patients with MS. METHODS: We identified 458 DMF-treated and 317 FTY-treated patients in a large academic MS center...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919496/cognitive-function-did-not-improve-after-initiation-of-natalizumab-treatment-in-relapsing-remitting-multiple-sclerosis-a-prospective-one-year-dual-control-group-study
#14
M Sundgren, Fredrik Piehl, Åke Wahlin, Tom Brismar
BACKGROUND: Cognitive impairment in multiple sclerosis (MS) is common and has severe implications. Natalizumab (NZ) has documented effects on relapse rate and radiological disease activity in relapsing-remitting MS (RRMS) but studies regarding its specific effects on cognitive functioning are few. Previous studies have reported improvement, however, often lacking relevant control groups. The objective of the present study was to evaluate the cognitive effects of NZ treatment, compared to patients on stable first-line treatment and healthy control subjects...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919495/clinical-characteristics-of-patients-with-multiple-sclerosis-enrolled-in-a-new-registry-in-egypt
#15
Magd Zakaria, Dina A Zamzam, Mohamed A Abdel Hafeez, Mahmoud S Swelam, Shaimaa S Khater, Mai F Fahmy, Ayman Abdel Hady, Mohamed M Fouad, Azza Abdel Nasser, Hany Aref, Mohsen Gadallah
BACKGROUND: Epidemiological studies of multiple sclerosis (MS) are lacking in Egypt. OBJECTIVE: To study the characteristics of Egyptian patients with multiple sclerosis in a new registry in a major tertiary referral centre in Cairo, Egypt. SUBJECT AND METHODS: Patients were from the project MS database of the Multiple Sclerosis Unit at Ain Shams University Hospitals (N=950). We conducted a detailed medical history and examination including the Expanded Disability Status Scale (EDSS)...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919494/physical-activity-in-pediatric-onset-multiple-sclerosis-validating-a-questionnaire-for-clinical-practice-and-research
#16
Dominique Kinnett-Hopkins, Stephanie A Grover, E Ann Yeh, Robert W Motl
BACKGROUND: Knowledge regarding physical activity (PA) and its benefits in pediatric onset multiple sclerosis (POMS) is growing and suggests high levels of inactivity. The utility of a validated screening tool for clinical settings is unknown. This study evaluated the Godin Leisure-Time Exercise Questionnaire (GLTEQ) as a measure of PA in POMS. METHODS: POMS patients (n=27) and healthy controls (n=45) wore an accelerometer over a 7-day period and then completed the GLTEQ...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919493/eleven-episodes-of-recurrent-optic-neuritis-of-the-same-eye-for-22-years-eventually-diagnosed-as-neuromyelitis-optica-spectrum-disorder
#17
Yih Chian Yew, Jyh Yung Hor, Thien Thien Lim, Ruban Kanesalingam, Yee Ming Ching, Masita Arip, P E Samuel Easaw, Gaik Bee Eow
It is difficult to predict whether a particular attack of neuromyelitis optica spectrum disorder (NMOSD) will affect the optic nerve [optic neuritis (ON): unilateral or bilateral], spinal cord (myelitis), brain or brainstem, or a combination of the above. We report an interesting case of recurrent ON of the same eye for a total of 11 episodes in a Chinese woman. Over a period of 22 years, the attacks only involved the left eye, and never the right eye and also no myelitis. For a prolonged duration, she was diagnosed as recurrent idiopathic ON...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919492/corrigendum-to-immunologic-mechanisms-of-fingolimod-and-the-role-of-immunosenescence-in-the-risk-of-cryptococcal-infection-a-case-report-and-review-of-literature-mult-scler-relat-disord-9-2016-158-162
#18
Elena Grebenciucova, Anthony T Reder, Jacqueline T Bernard
No abstract text is available yet for this article.
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919491/comparing-outcomes-from-clinical-studies-of-oral-disease-modifying-therapies-dimethyl-fumarate-fingolimod-and-teriflunomide-in-relapsing-ms-assessing-absolute-differences-using-a-number-needed-to-treat-analysis
#19
Mark S Freedman, Xavier Montalban, Aaron E Miller, Catherine Dive-Pouletty, Steven Hass, Karthinathan Thangavelu, Thomas P Leist
Dimethyl fumarate (DMF), fingolimod, and teriflunomide are oral disease-modifying therapies (DMTs) indicated for the treatment of relapsing-remitting multiple sclerosis. Despite well-established limitations of cross-trial comparisons, DMTs are still frequently compared in terms of relative reductions in specific endpoints, most commonly annualized relapse rate. Consideration of absolute risk reduction and number needed to treat (NNT) provides an alternative approach to assess the magnitude of treatment effect and can provide valuable additional information on therapeutic gain...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919490/quantitative-visual-tests-after-poorly-recovered-optic-neuritis-due-to-multiple-sclerosis
#20
Erin E Longbrake, Samantha Lancia, Nhial Tutlam, Kathryn Trinkaus, Robert T Naismith
BACKGROUND: Visual dysfunction in MS can be quantified using a variety of tests. Many vision tests have not been formally evaluated among MS patients with existing visual dysfunction. OBJECTIVE: Evaluate several versions of visual acuity and contrast sensitivity tests, measures of central and peripheral vision, retina structure, electrophysiologic function, and quality of life among MS patients with moderate/severe visual dysfunction. METHODS: Cross-sectional study of 46 patients with stable, incompletely recovered optic neuritis...
November 2016: Multiple Sclerosis and related Disorders
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