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Multiple Sclerosis and related Disorders

Luigi Lavorgna, Giovanna Borriello, Sabrina Esposito, Gianmarco Abbadessa, Rocco Capuano, Laura De Giglio, Alessandra Logoteta, Carlo Pozzilli, Gioacchino Tedeschi, Simona Bonavita
BACKGROUND: In order to anticipate the diagnosis of Multiple Sclerosis (MS), the diagnostic criteria had been reviewed several times in the last years. OBJECTIVE: We wanted to understand whether earlier diagnoses of MS have impacted on therapeutic management of the disease. METHODS: We designed a 22-item survey posted on SMsocialnetwork, a webplatform with a medical supervision, dedicated to Italian MS patients. We collected socio-demographic data, disease and treatment-related information of 1000 patients...
November 5, 2018: Multiple Sclerosis and related Disorders
Jonathan Ciron, Clarisse Carra-Dallière, Xavier Ayrignac, Jean-Philippe Neau, Nicolas Maubeuge, Pierre Labauge
Combined central and peripheral demyelination (CCPD) is a rare chronic inflammatory disorder of the nervous system. In this article, we report on a CCPD patient with a very unusual pattern of central demyelination, comprising recurrent cerebral tumefactive demyelinating lesions (three times, each one in a new area of the brain) and one episode of longitudinally extensive transverse myelitis. This patient could not be classified as having multiple sclerosis, or neuromyelitis optica spectrum disorder, or any other well-known inflammatory disorder of the central nervous system, associated with demyelinating neuropathy...
November 3, 2018: Multiple Sclerosis and related Disorders
Zhifeng Mao, César Álvarez-González, Kimberley Allen-Philbey, Stefania De Trane, Ozlem Yildiz, Tom Campion, Ashok Adams, Benjamin P Turner, Monica Marta, Sharmilee Gnanapavan, Maria Espasandin, Joela Mathews, Gavin Giovannoni, David Baker, Klaus Schmierer
BACKGROUND: Whilst there is a broad selection of drugs licensed as disease modifying treatments (DMTs) for people with relapsing multiple sclerosis (pwRMS), access to DMTs remains restricted, particularly for people with progressive MS (pwPMS). Cladribine has shown efficacy at all stages of MS. Following withdrawal from the market of oral cladribine in 2011, partly due to issues associated with lymphopenia, and following a thorough risk assessment, we started using subcutaneously injected cladribine (Litak® ) to treat both pwRMS and pwPMS...
November 2, 2018: Multiple Sclerosis and related Disorders
Masoud Etemadifar, Yalda Nikanpour, Amir Neshatfar, Fatemeh Sabeti
Tumors have been frequently reported to be associated with neuromyelitis optica (NMO). Here we review a case of a 34-year-old woman who presented with complaint of one-sided visual loss. All Lab tests exhibited negative results which decreased the possibility of Auto-immune or neuro-inflammatory disorders. Magnetic resonance imaging (MRI) of the brain and spinal cord was done as a part of work up, which showed Meningioma in anterior fossa without any other findings supporting neuro-demyelinating disorders. After complete surgical removal of the meningioma, patient's visual loss was completely resolved...
November 2, 2018: Multiple Sclerosis and related Disorders
Frédéric London, Katharina Hohenbichler, Thierry Duprez, Christian Sindic, Vincent van Pesch
No abstract text is available yet for this article.
November 1, 2018: Multiple Sclerosis and related Disorders
Xiaofan You, Lirong Yan, Xin Li, Ying Pang, Xiaolei Guo, Jing Ye, Hongtao Hu
OBJECTIVE: The aims of this study were to report brain characteristic abnormalities and to evaluate the relationship of blood-brain barrier (BBB) disruption and brain lesions in Chinese patients with NMOSD. METHODS: Brain magnetic resonance imaging characteristics and cerebrospinal fluid (CSF) laboratory tests of 121 patients with NMOSD at acute attack were reviewed retrospectively. Qalb (CSF albumin/serum albumin) was used for assessment of disruption of BBB. RESULTS: Brain MRI abnormalities were observed in 36...
October 30, 2018: Multiple Sclerosis and related Disorders
Austin Trotter, Emily Anstadt, Robert B Clark, Frank Nichols, Alok Dwivedi, Koko Aung, Jorge L Cervantes
Phospholipases A2 (PLA2 ) are a diverse group of enzymes that cleave the fatty acids of membrane phospholipids. They play critical roles in pathogenesis of neurodegenerative diseases such as multiple sclerosis by enhancing oxidative stress and initiating inflammation. The levels of PLA2 activity in MS patients compared to controls and role of inhibiting PLA2 activity on severity scores in different experimental models are not comprehensively assessed in the light of varying evidence from published studies. The objective of this systematic review is to determine the association between PLA2 activity and multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE)...
October 30, 2018: Multiple Sclerosis and related Disorders
Antje S Mefferd, Abish Lai, Francesca Bagnato
BACKGROUND: Multiple sclerosis can affect the speech motor system and result in dysarthria. OBJECTIVES: This pilot study sought to identify tongue, lip, and jaw motor deficits in persons with dysarthria due to multiple sclerosis (PwDMS) to better understand the speech motor mechanisms that underlie their aberrant speech. METHODS: Tongue and jaw movements during "ai" and lower lip and jaw movements during "bob"were examined in eleven PwDMS and fourteen age- and sex-matched controls using three-dimensional electromagnetic articulography...
October 30, 2018: Multiple Sclerosis and related Disorders
Pauline Luczynski, Cornelia Laule, Ging-Yuek Robin Hsiung, G R Wayne Moore, Helen Tremlett
BACKGROUND: People with multiple sclerosis (MS) are living longer than ever and will likely face the same age-related diseases as other seniors; however, there is strikingly little information on the coexistence of MS with many common diseases of aging. In particular, little appears to be known about the coexistence of MS with Alzheimer's disease (AD), the most common form of dementia. METHODS: In this review, we explore what is known about the coexistence of MS and AD, including a focused literature search to identify any reports of individuals with both MS and AD (PubMed, to May 2017)...
October 27, 2018: Multiple Sclerosis and related Disorders
Leora Hershkovitz, Ofir Malcay, Yevgenia Grinberg, Shani Berkowitz, Alon Kalron
Fear of falling (FoF) and actual falling typifies two common complaints in people with MS (PwMS). The objective of our study was to examine the Instrumented Timed-Up-and-Go test (ITUG) in relation to falls and FoF in PwMS. This case-control study comprised 75 participants; 50 PwMS (33 women), aged 44.2 (S.D = 7.2) and 25 healthy subjects (18 women) aged 44.4 (S.D = 8.6). The ITUG test was evaluated by the APDM Mobility lab (Portland, OR, USA) and was completed under two task conditions, normal and while performing a cognitive test (ITUG-cog)...
October 27, 2018: Multiple Sclerosis and related Disorders
Ndiaga Matar Gaye, Maouly Fall, Alassane Mamadou Diop, Samy Mohamed Lemine Dadah, Mamadou Ka, Ousmane Cissé, Ngor Side Diagne, Marième Soda Diop-Sène, Adjaratou Dieynabou Sow, Anna Modji Basse-Faye, Mamadou Moustapha Sarr, Kamadore Touré, Lala Bouna Seck, Moustapha Ndiaye, Amadou Gallo Diop
BACKGROUND: Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system. In Sub-Saharan Africa, publications are rare and deal with isolated cases. Our goal was to analyze the characteristics of NMO spectrum disorders in a Senegalese cohort compiled in Dakar. PATIENTS AND METHOD: This was a retrospective descriptive study conducted at the Neurology Department of Fann Teaching Hospital. We included all patients with NMO-SD according to the 2014 diagnostic criteria...
October 26, 2018: Multiple Sclerosis and related Disorders
Ruth Ann Marrie, Ronak Patel, Chase R Figley, Jennifer Kornelsen, James M Bolton, Lesley Graff, Erin L Mazerolle, James J Marriott, Charles N Bernstein
OBJECTIVE: To determine whether comorbid diabetes and hypertension are associated with cognition in multiple sclerosis (MS) after accounting for psychiatric comorbidities. METHODS: Participants completed a structured psychiatric interview, the Hospital Anxiety and Depression Scale (HADS), a comorbidity questionnaire, and cognitive testing including the Symbol Digit Modalities Test (SDMT), California Verbal Learning Test (CVLT-II), Brief Visuospatial Memory Test-Revised (BVMT-R), and verbal fluency...
October 23, 2018: Multiple Sclerosis and related Disorders
Henriette Lynge Thomsen, Elise Barsøe Jessen, Moschoula Passali, Jette Lautrup Frederiksen
BACKGROUND: There is an increasing interest in diet as a modifying factor in multiple sclerosis (MS), and gluten has been suggested to affect MS. OBJECTIVE: The aim of this systematic review is to qualitatively evaluate the evidence on the role of gluten in MS. METHODS: A review protocol was submitted to PROSPERO. A systematic literature search was conducted in PubMed, Web of Science, Scopus, Embase, Cab Abstracts, and Google Scholar. Studies on patients with MS, clinically isolated syndrome, or celiac disease presenting with MS-related markers were included, if they investigated effects of diets containing specified amounts of gluten or associations between gluten sensitivities and MS...
October 23, 2018: Multiple Sclerosis and related Disorders
Konstantin Huhn, Daniela Senger, Kathrin S Utz, Manuel Schmidt, Kilian Fröhlich, Anne Waschbisch, Frank Seifert, Arnd Dörfler, De-Hyung Lee, Ralf A Linker
BACKGROUND: Over the last decade, therapy of relapsing remitting multiple sclerosis (RRMS) has evolved with the approval of several new treatment concepts. Thus, treatment goals have become more ambitious aiming at "no evidence of disease activity" (NEDA). As NEDA-3, this concept comprises freedom of clinical disease progression and relapses as well as inflammatory MRI activity. So far, data on NEDA status mainly stem from post-hoc analyses of drug approval studies. Yet, less is known about the significance of NEDA in "real-world" clinical settings...
October 23, 2018: Multiple Sclerosis and related Disorders
D P Holland, D K Schlüter, C A Young, R J Mills, D J Rog, H L Ford, K Orchard
BACKGROUND: Coping positively and negatively influences psychosocial and other outcomes in multiple sclerosis (MS), but there is conflicting evidence about the use of different coping strategies and their associations with demographic and disease characteristics. Our aims were to examine which coping strategies are used by a large sample of people with MS, then to identify any associations between demographic and disease related factors with use of individual coping strategies. METHODS: Participants in the Trajectories of Outcomes in Neurological Conditions (TONiC) study completed the Coping Orientations to Problems Experienced (COPE60) questionnaire...
October 22, 2018: Multiple Sclerosis and related Disorders
Brenda Young, Emmanuelle Waubant, Sabeen Lulu, Jennifer Graves
OBJECTIVES: To determine the association of age of onset and puberty with relapse rate in boys with pediatric multiple sclerosis (MS). BACKGROUND: While sex steroid hormones have been shown to have immune effects, it is not known how age or puberty influence disease course in boys with MS. We have previously shown an association in girls with menarche and risk of relapse. METHODS: Patients from the UCSF Regional Pediatric MS Center were included in this retrospective study...
October 22, 2018: Multiple Sclerosis and related Disorders
B Mark Hoffman, Nuhad Abou Zeid, Umar Alam, James B Caress
BACKGROUND: Alemtuzumab administration is known to cause secondary autoimmune disease but has not been associated with the development of neurologic autoimmune conditions. Lambert-Eaton myasthenic syndrome (LEMS) is caused by autoantibodies directed against calcium channels on the neuromuscular junction. CASE REPORT: We report a case of a patient with relapsing-remitting multiple sclerosis (RRMS) treated with alemtuzumab who develop generalized weakness initially attributed to progression of MS but eventually determined to be due to LEMS...
October 22, 2018: Multiple Sclerosis and related Disorders
Masoud Etemadifar, Maedeh Abbasi, Mehri Salari, Fatemeh Etemadifar, Hossein Tavakoli
BACKGROUND: Recent studies have suggested that anti-MOG antibodies and optic neuritis are associated and anti-MOG antibody positive patients have had better recoveries. The purpose of this study was to compare the clinical course and treatment outcome of MOG-Ab associated and non-MOG-Ab associated ON. METHODS: Patients diagnosed with optic neuritis were referred for brain and cervical MRI. Blood samples were also taken to measure MOG antibody and NMO antibody levels...
October 19, 2018: Multiple Sclerosis and related Disorders
L Lorefice, J Frau, G Coghe, R Pitzalis, I Gessa, F Contu, M A Barracciu, M G Marrosu, E Cocco, G Fenu
BACKGROUND: Some studies have indicated the importance of considering the presence of vascular comorbidities as negative prognostic factors for MRI outcomes in multiple sclerosis (MS). This study aimed to evaluate the possible influence of the most frequent vascular risk factors on brain volume in MS, also exploring the burden of their combined effects. METHODS: MS patients with at least one vascular risk factor and a control group of MS patients were enrolled. Patients underwent brain MRI and the volumes of the whole brain (WB), white matter (WM), grey matter (GM), and cortical GM were estimated by SIENAX...
October 16, 2018: Multiple Sclerosis and related Disorders
Mohammad Dehghanifiroozabadi, Parisa Noferesti, Alireza Amirabadizadeh, Samaneh Nakhaee, Jan Aaseth, Farshid Noorbakhsh, Omid Mehrpour
BACKGROUND: Multiple sclerosis (MS) is a debilitating disease of the central nervous system, with disseminating demyelination of nerve fibers and spinal cord. Exposure to heavy metals seems to be associated with a higher incidence of MS. Few studies have assessed the correlation of the incidence of MS with heavy metal concentrations. The present study aimed to assess the relationship between blood lead levels and MS. METHODS: This case-control study was conducted on 29 MS patients and 29 healthy control persons...
October 15, 2018: Multiple Sclerosis and related Disorders
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