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Multiple Sclerosis and related Disorders

Ozden Kamisli, Ceren Acar, Mert Sozen, Mehmet Tecellioglu, Fatma Ebru Yücel, Dilara Vaizoglu, Cemal Özcan
BACKGROUND: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. METHODS: 167 MS patients and 146 healthy control subjects were included in the present study...
January 9, 2018: Multiple Sclerosis and related Disorders
K Soelberg, H P B Skejoe, J Grauslund, T J Smith, S T Lillevang, S Jarius, B Wildemann, F Paul, N Asgari
BACKGROUND: Optic neuritis (ON) is a focal demyelinating event, which may evolve into multiple sclerosis (MS). OBJECTIVE: To study MRI characteristics in the acute phase of the first ON episode. METHODS: A prospective population-based study was performed on 31 patients with a first episode of acute ON with a one year follow-up. MRI, clinical evaluation, and detection of aquaporin-4 (AQP4)-IgG and myelin oligodendrocyte glycoprotein (MOG)-IgG was undertaken...
December 25, 2017: Multiple Sclerosis and related Disorders
Nabeel M Syed, Imran Nazir Ahmad, Aamna Batool Khan, Arsalan Ahmad
No abstract text is available yet for this article.
December 25, 2017: Multiple Sclerosis and related Disorders
Efthimios Dardiotis, Anastasia Nousia, Vasileios Siokas, Zisis Tsouris, Athina Andravizou, Alexios-Fotios A Mentis, Despoina Florou, Lambros Messinis, Grigorios Nasios
IMPORTANCE: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by relapses and a progressive course that may lead to accumulation of physical and cognitive disability. Cognitive training interventions seem to improve the cognitive performance of MS patients. The aim of the present meta-analysis is to quantitatively investigate the effect of computer-based cognitive rehabilitation on the neuropsychological performance of patients with MS...
December 24, 2017: Multiple Sclerosis and related Disorders
Mohammad Hossein Harirchian, Farzad Fatehi, Payam Sarraf, Niyaz Mohammadzadeh Honarvar, Sama Bitarafan
BACKGROUND: Several studies have suggested that the existence of a history of multiple sclerosis (MS) in family, is one of the predisposing factors for MS. Based on our knowledge, the review and estimation of the prevalence of familial multiple sclerosis (FMS) in the world has not been reported up to now. This study is a systematic review and a meta-analysis of FMS prevalence in the world. METHODS: Two researchers searched "epidemiology" or "prevalence" or "incidence" and "familial multiple sclerosis" as relevant keywords in international databases such as PubMed, web of science and Scopus up to 2016...
December 24, 2017: Multiple Sclerosis and related Disorders
Philippe Beauchemin, Raffaele Iorio, Anthony L Traboulsee, Thalia Field, Anna V Tinker, Robert L Carruthers
BACKGROUND: Paraneoplastic syndromes are remote effects of cancer caused by an autoimmune response triggered by tumor cells. Paraneoplastic Neuromyelitis Optica Spectrum Disorders (NMOSD) has been previously described, but the underlying mechanism for these rare cases is not well characterized. This paper presents a newly described case series of paraneoplastic NMOSD, including 2 new histological types of cancer and histological validation. METHODS: The UBC NMO clinic database was surveyed and identified 6 patients with paraneoplastic NMOSD...
December 23, 2017: Multiple Sclerosis and related Disorders
Katrin Hanken, Yoselin Francis, Andreas Kastrup, Paul Eling, Jan Klein, Helmut Hildebrandt
BACKGROUND: Recently, we proposed a model explaining the origin of fatigue in multiple sclerosis (MS) patients. This model assumes that the feeling of fatigue results from inflammation-induced information processing within interoceptive brain areas. OBJECTIVES: To investigate the association between self-reported cognitive fatigue and structural integrity of interoceptive brain areas in MS patients. METHODS: 95 MS patients and 28 healthy controls participated in this study...
December 21, 2017: Multiple Sclerosis and related Disorders
Marco A Lana-Peixoto, Denison Pedrosa, Natália Talim, Juliana M S S Amaral, Pâmela E Lacerda, Rodrigo Kleinpaul
Dengue fever (DF) is a common arbovirosis in tropical and subtropical countries and may be associated with a wide range of neurological complications. We describe a 41-year-old man who developed weakness in the right arm and lower limbs, paresthesia in the upper and lower limbs, and sphincter disturbance four weeks following DF. Examination disclosed a wheel-chair bound patient with urinary catheter, areflexia in the lower limbs, and a sensation level at T10. Spinal magnetic resonance imaging showed diffuse lesions with contrast-enhanced areas extending from the medullary-cervical junction to the conus medullaris and cauda equina...
December 21, 2017: Multiple Sclerosis and related Disorders
C Ammitzbøll, T B Dyrby, M Lyksborg, K Schreiber, R Ratzer, J Romme Christensen, P Iversen, M Magyari, E Garde, P S Sørensen, H R Siebner, F Sellebjerg
BACKGROUND: Progressive multiple sclerosis (MS) is characterised by diffuse changes on brain magnetic resonance imaging (MRI), which complicates the use of MRI as a diagnostic and prognostic marker. The relationship between MRI measures (conventional and non-conventional) and clinical disability in progressive MS therefore warrants further investigation. OBJECTIVE: To investigate the relationship between clinical disability and MRI measures in patients with progressive MS...
December 18, 2017: Multiple Sclerosis and related Disorders
Elijah Edward Rhone, Peter Siu Pan Cho, Surinder S Birring, James Galloway, Eli Silber
As new immunomodulatory therapies continue to be licensed for use in Multiple Sclerosis, it is important to remain vigilant for new, unexpected associations relating to these medications. We highlight this by reporting on a case of a 45-year-old man who developed systemic, non-specific symptoms following long term use of daclizumab and was subsequently diagnosed with sarcoidosis. We go on to briefly discuss the action of daclizumab, in particular the effect it has on CD56bright natural killer cells, a cell type that has been investigated in relation to sarcoidosis...
December 18, 2017: Multiple Sclerosis and related Disorders
Stefania Barone, Sara Scannapieco, Carlo Torti, Enrica Filippelli, Vincenzo Pisani, Alfredo Granata, Domenico Console, Giulio Demonte, Tiziana Tallarico, Serena Polidoro, Aldo Quattrone, Paola Valentino
The anti-CD52 monoclonal antibody alemtuzumab is a highly active treatment for multiple sclerosis (MS) causing rapid depletion of B and T lymphocytes with nadir one month after last infusion. Opportunistic Cytomegalovirus (CMV) infections have been reported in MS patients treated with this drug. We report one patient who developed a CMV reactivation with hepatic involvement three weeks after the first cycle of alemtuzumab. This patient, promptly diagnosed and treated, achieved a complete recovery with valganciclovir...
December 18, 2017: Multiple Sclerosis and related Disorders
Ruth Ann Marrie, Lixia Zhang, Lisa M Lix, Lesley A Graff, John R Walker, John D Fisk, Scott B Patten, Carol A Hitchon, James M Bolton, Jitender Sareen, Renée El-Gabalawy, James J Marriott, Charles N Bernstein
OBJECTIVE: We aimed to evaluate the validity and reliability of multiple screening measures for depression and anxiety for use in the clinical care of people with multiple sclerosis (MS). METHODS: Participants with MS completed the Patient Health Questionnaire (PHQ-9), Hospital Anxiety and Depression Scale (HADS), Kessler-6 Distress Scale, PROMIS Emotional Distress Depression Short-Form 8a (PROMIS Depression) and Anxiety Short-Form 8a (PROMIS Anxiety), Generalized Anxiety Disorder 7-item Scale (GAD-7), and the Overall Anxiety and Severity Impairment Scale (OASIS)...
December 16, 2017: Multiple Sclerosis and related Disorders
M Baharnoori, C T Gonzalez, A Chua, C Diaz-Cruz, B C Healy, J Stankiewicz, H L Weiner, T Chitnis
BACKGROUND: There is limited data regarding the predictors of hematological abnormalities in multiple sclerosis (MS) patients treated with dimethyl fumarate (DMF) or fingolimod (FNG), and the impact of treatment switch on lymphocyte and leukocyte count METHODS: We identified 405 patients on DMF and 300 patients on FNG (treatment duration: at least 12 month) within a large prospective study of MS patients conducted at the Partners MS Center, Brigham and Women's Hospital (CLIMB study) between Jan 2011 to Feb 2016...
December 14, 2017: Multiple Sclerosis and related Disorders
Julia Smith, Amanda S Bruce, Morgan Glusman, Joanie Thelen, Sharon Lynch, Jared M Bruce
BACKGROUND: Fatigue is prevalent in Multiple Sclerosis (MS), but little research indicates how to best quantify changes in fatigue over time. OBJECTIVE: Evaluate reliable change on the abbreviated Modified Fatigue Impact Scale (MFIS-5) in MS patients. METHODS: One-hundred sixty eight MS patients completed the MFIS-5 at baseline and follow-up as part of two larger studies. Test-retest reliability scores and reliable change indices were calculated...
December 14, 2017: Multiple Sclerosis and related Disorders
Guoqiao Wang, Ruth Ann Marrie, Robert J Fox, Tuula Tyry, Stacey S Cofield, Gary R Cutter, Amber Salter
BACKGROUND: Bladder, bowel, and sexual symptoms are common among persons with multiple sclerosis (MS). We aimed to investigate the frequency and severity of bladder, bowel, and sexual symptoms, the relationships between these symptoms, satisfaction with treatment of these symptoms, and factors associated with symptom severity and treatment satisfaction. METHODS: In the fall 2010, we surveyed participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding the severity of being bothered by bladder, bowel, and sexual symptoms, their satisfaction of health providers' inquiry and treatment with these symptoms, and whether their quality of life (QOL) had changed with the treatment...
December 14, 2017: Multiple Sclerosis and related Disorders
Tarig Mohammed Abkur, Hugh Kearney, Michael J Hennessy
Natalizumab treatment of multiple sclerosis (MS) is associated with a risk of developing progressive multifocal leukoencephalopathy (PML), a rare opportunistic viral demyelinating disease caused by reactivation of John Cunningham virus (JCV). Herein, we report a case of a 40-year-old woman who developed refractory temporal lobe epilepsy; one year after recovery form Natalizumab-induced PML. Localisation related epilepsy, which may be refractory in nature, as in this case report, is a potential chronic disabling complication of PML...
December 13, 2017: Multiple Sclerosis and related Disorders
Eero Rissanen, Kari Remes, Laura Airas
We present here the first MS-case where rituximab-treatment led to grade IV neutropenia, with hospitalization and treatment of a serious infection with broad-spectrum antibiotics. The neutropenia resolved promptly with granulocyte-colony stimulating factor-treatment and the patient recovered well. Due to risk of recurring neutropenia rituximab-treatment was not re-administered. We discuss the mechanisms and occurrence of neutropenia as a side effect to rituximab-treatment of MS, and remind of the importance of monitoring rituximab-treated MS-patients for this rare but potentially dangerous side effect...
December 12, 2017: Multiple Sclerosis and related Disorders
Inês Correia, Joana Jesus Ribeiro, Luís Isidoro, Sónia Batista, Carla Nunes, Carmo Macário, Catarina Borges, Jorge Tomaz, Lívia Sousa
BACKGROUND: Relapses in Multiple Sclerosis (MS) are often associated with significant disability impairment which is resultant from poor response to corticosteroids. In such severe cases, plasma exchange (PLEX) may be used, although only a few studies with MS patients have been reported. Our objective was to evaluate the effectiveness of PLEX in severe relapses of MS. METHODS: Retrospective study of MS patients treated with PLEX in acute relapses. Data regarding EDSS, annualized relapse rate (ARR), treatment with corticosteroids, number of PLEX sessions, adverse events, and gadolinium enhancement in brain MRI were analysed...
December 7, 2017: Multiple Sclerosis and related Disorders
Gautam Adusumilli, Kathryn Trinkaus, Peng Sun, Samantha Lancia, Jeffrey D Viox, Jie Wen, Robert T Naismith, Anne H Cross
BACKGROUND: Improved imaging methods are critical to assess neurodegeneration and remyelination in multiple sclerosis. Chronic hypointensities observed on T1-weighted brain MRI, "persistent black holes," reflect severe focal tissue damage. Present measures consist of determining persistent black holes numbers and volumes, but do not quantitate severity of individual lesions. OBJECTIVE: Develop a method to differentiate black and gray holes and estimate the severity of individual multiple sclerosis lesions using standard magnetic resonance imaging...
December 2, 2017: Multiple Sclerosis and related Disorders
James John Marriott, Hui Chen, Randall Fransoo, Ruth Ann Marrie
BACKGROUND: Severe relapses that required treatment were important outcomes in the sentinel trials of disease-modifying therapy (DMT). Identifying such relapses in administrative data would allow comparative-effectiveness studies of DMTs to be conducted in real-world clinical settings. METHODS: All relapsing-remitting (RRMS) and secondary-progressive (SPMS) patients living in Manitoba between 1999 and 2015 were identified using a validated case definition and linkage to the Manitoba MS Clinic database...
December 2, 2017: Multiple Sclerosis and related Disorders
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