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Multiple Sclerosis and related Disorders

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https://www.readbyqxmd.com/read/30005357/limbic-encephalitis-associated-with-systemic-sclerosis
#1
Pia De Stefano, Carlo Chizzolini, Patrice H Lalive, Agustina M Lascano
We report the case of a patient affected by systemic sclerosis (SSc) who developed autoimmune limbic encephalitis, which improved under immunosuppressant agents and high-dose intravenous immunoglobulins. In our patient the autoimmune encephalitis occurred during apparently quiescent SSc, though concomitantly with novel arthritis. Moreover, our patient showed auto-antibodies directed against SSA antigen but the panel of auto-antibodies associated with autoimmune encephalitis was negative. We discuss the potential for immunopathogenic inflammatory events affecting the central nervous system in SSc then favoring the occurrence of autoimmune encephalitic disorders...
July 10, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29982107/efficacy-and-safety-of-natalizumab-extended-interval-dosing
#2
Bassem I Yamout, Mohamad Ali Sahraian, Nabil El Ayoubi, Hani Tamim, Johnny Nicolas, Samia J Khoury, Maya M Zeineddine
OBJECTIVE: It is postulated that extending the dosing interval of natalizumab (NTZ) from 4 to 5-8 weeks might decrease the risk of progressive multifocal leukoencephalopathy (PML). The aim of this study was to assess the effect of extended interval dosing (EID) on the therapeutic efficacy of natalizumab. METHODS: We reviewed 85 patients treated at two MS centers in the Middle East with natalizumab for at least 6 months using EID. Patients were shifted after an initial treatment period at standard interval dosing (SID) to an EID ranging from 5-8 weeks...
July 5, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30007180/the-long-term-impact-of-multiple-sclerosis-on-the-risk-of-divorce
#3
Erik Landfeldt, Anna Castelo-Branco, Axel Svedbom, Emil Löfroth, Andrius Kavaliunas, Jan Hillert
BACKGROUND: Several studies have investigated the impact of multiple sclerosis (MS) on the risk of divorce. However, current evidence is inconclusive and limited by e.g. small sample populations, short follow-up, and/or lack of a control group. The objective of this retrospective, observational study was to estimate the long-term impact of MS on the risk of divorce. METHODS: Swedish patients diagnosed with MS between 1975 and 2012 were identified in a nationwide disease-specific register (the Swedish Multiple Sclerosis Registry) and matched with general population controls based on age, sex, region of residency, and marital status...
July 3, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29982109/teeth-loss-after-teriflunomide-treatment-casual-or-causal-a-short-case-series
#4
Veria Vacchiano, Nicola Frattaruolo, Luca Mancinelli, Matteo Foschi, Antonio Carotenuto, Cinzia Scandellari, Maurizio Piattelli, Vincenzo Brescia Morra, Alessandra Lugaresi
BACKGROUND: Teriflunomide is a once-daily oral immunomodulator approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) with a consistent safety profile in clinical trials. We report three cases of multiple teeth loss during teriflunomide treatment. CASE REPORTS: Case 1: a 39 year-old woman started teriflunomide for RRMS, switching from interferon beta. Four months later she complained about mandibular pain followed by the sudden loss of 4 teeth, in the absence of bleeding or trauma...
June 30, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29982108/white-matter-hyperintensities-in-myotonic-dystrophy-type-2-not-always-another-expression-of-the-disease
#5
M Karatzikou, C Bakirtzis, J Nikolaidis, D Parisis, N Grigoriadis
Myotonic dystrophy type 2(DM2), inherited in an autosomal, dominant manner, is clinically characterized by muscle weakness, variable myotonia, cataract and multiorgan involvement, including the Central Nervous System. Recent data from literature indicate a possible autoimmune susceptibility of patients with DM2, while white matter abnormalities are a common feature of the disease. We report herein the case of a 38-year old woman, with the rare co-existence of DM2 and MS and argue about the challenging differential diagnosis if CNS involvement is present in DM2 patients...
June 30, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29990894/a-phase-ii-baseline-versus-treatment-study-to-determine-the-efficacy-of-raltegravir-isentress-in-preventing-progression-of-relapsing-remitting-multiple-sclerosis-as-determined-by-gadolinium-enhanced-mri-the-inspire-study
#6
Julian Gold, Monica Marta, Ute C Meier, Tove Christensen, David Miller, Daniel Altmann, David Holden, Lucia Bianchi, Rocco Adiutori, David MacManus, Tarek Yousry, Klaus Schmierer, Benjamin Turner, Gavin Giovannoni
BACKGROUND: Although the aetiology of multiple sclerosis (MS) remains elusive, it is clear that Epstein Barr virus (EBV) and possibly other viruses play a role in the pathogenesis of MS. Laboratory evidence suggests that human endogenous retroviruses (HERVs) could also have a role, but no interventional therapy has determined what will happen if HERVs are suppressed. Recent epidemiological evidence indicates patients with HIV infection have a significantly lower risk of developing MS and that HIV antiretroviral therapies may be coincidentally inhibiting HERVs, or other retroelements, that could be implicated in MS...
June 28, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29982111/effects-of-exercise-training-on-cytokines-and-adipokines-in-multiple-sclerosis-a-systematic-review
#7
REVIEW
Raoof Negaresh, Robert W Motl, Motahare Mokhtarzade, Ulrik Dalgas, Darpan Patel, Mehdieh Molanouri Shamsi, Nastaran Majdinasab, Rouholah Ranjbar, Philipp Zimmer, Julien S Baker
BACKGROUND: Physical activity, particularly exercise training, is an evidence-based approach for managing symptoms, restoring function and improving overall wellness in people with multiple sclerosis (MS). Several recent studies have argued for a potential disease modifying effect of exercise in people with MS, and among the potential mediating mechanisms are exercise training effects on both cytokines and adipokines. The objectives of this study were to perform a systematic review of exercise training effects on cytokine and adipokine profiles in persons with MS...
June 28, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29982105/trunk-control-the-essence-for-upper-limb-functionality-in-patients-with-multiple-sclerosis
#8
Nilufer Cetisli Korkmaz, Tuba Can Akman, Gonul Kilavuz Oren, Levent Sinan Bir
BACKGROUND: Multiple sclerosis (MS) involves impaired trunk control, leading to impaired upper-limb functionality, dexterity, and independence. Deciding early on a comprehensive approach pointing of functional disturbances and personal needs is essential for a multimodal, individualized, goal-oriented assessment and treatment program, recognizing the broad range of symptoms and disabilities associated with MS. In clinical practice, postural control of the trunk is purported to be an important contributor to voluntary upper-limb function, including motor control and dexterity...
June 28, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29982110/cardiac-autonomic-function-during-postural-changes-and-exercise-in-people-with-multiple-sclerosis-a-cross-sectional-study
#9
Elisa Gervasoni, Marco Bove, Mattia Sinatra, Cristina Grosso, Marco Rovaris, Davide Cattaneo, Giampiero Merati
BACKGROUND: People with multiple sclerosis (PwMS) often develop an autonomic dysfunction (AD), which onset should be assessed early at a subclinical level, as it may interfere with pharmacological treatments and exercise. OBJECTIVE: To evaluate basal cardiac autonomic tone, its modulations during sit-to-stand, sub-maximal exercise and recovery in PwMS without clinical overt AD and its relationships with fatigue perception. METHODS: Twenty-three PwMS (55 ± 8 yrs [mean ± SD]; EDSS score 5...
June 27, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30005356/incorporating-machine-learning-approaches-to-assess-putative-environmental-risk-factors-for-multiple-sclerosis
#10
Ellen M Mowry, Anna K Hedström, Milena A Gianfrancesco, Xiaorong Shao, Catherine A Schaefer, Ling Shen, Kalliope H Bellesis, Farren B S Briggs, Tomas Olsson, Lars Alfredsson, Lisa F Barcellos
BACKGROUND: Multiple sclerosis (MS) incidence has increased recently, particularly in women, suggesting a possible role of one or more environmental exposures in MS risk. The study objective was to determine if animal, dietary, recreational, or occupational exposures are associated with MS risk. METHODS: Least absolute shrinkage and selection operator (LASSO) regression was used to identify a subset of exposures with potential relevance to disease in a large population-based (Kaiser Permanente Northern California [KPNC]) case-control study...
June 23, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29982106/access-to-social-security-benefits-among-multiple-sclerosis-patients-in-italy-a-cross-sectional-study
#11
Marco Bo, Lorena Charrier, Sabina Bartalini, Matteo Benvenuti, Alessandra Oggero, Monica Ulivelli, Mario Gabbrielli, Antonio Bertolotto, Maria Michela Gianino
BACKGROUND: Knowledge concerning the predictors of social security benefits and the proportion of Multiple Sclerosis (MS) patients receiving these benefits is very limited. OBJECTIVE: To estimate the likelihood of receiving social security benefits for Italian MS patients. METHODS: From September 2014 to November 2015, we interviewed MS outpatients from two Italian MS clinics to collect information regarding their personal data, clinical and working history, and access to social security benefits...
June 23, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29966829/radiologically-isolated-syndrome-in-children-current-knowledge-and-future-directions
#12
REVIEW
Colin Wilbur, E Ann Yeh
As the use of magnetic resonance imaging (MRI) grows in clinical practice, clinicians are increasingly faced with the difficult task of interpreting the significance of incidental findings on brain MRI. Among individuals found to have incidental brain MRI findings, a small number have white matter abnormalities on MRI that resemble the demyelinating lesions of multiple sclerosis (MS) in the absence of a history of relevant clinical symptoms. This has been termed radiologically isolated syndrome (RIS). Recent years have seen growing interest in RIS, with observational studies that have specifically focused on answering questions regarding the subsequent risk of future clinical events and diagnosis of MS in adults and children with these findings...
June 21, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29936325/2017-mcdonald-diagnostic-criteria-a-review-of-the-evidence
#13
REVIEW
N McNicholas, M Hutchinson, C McGuigan, J Chataway
The diagnosis of Multiple Sclerosis (MS) has continuously evolved, allowing for an earlier and more accurate diagnosis of MS over time. The McDonald Criteria for diagnosis of MS were originally proposed in 2001, with previous revisions in both 2005 and 2010. The International Panel on Diagnosis in MS have recently reviewed the 2010 McDonald Criteria, and made recommendations for the revised 2017 McDonald Criteria. Any revisions made relied entirely on the available evidence, and not expert opinion. In this review, we provide an overview of the recent 2017 revisions to the McDonald Criteria, focusing in particular on the motivating evidence behind the recommendations made...
June 21, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29960142/an-introduction-to-mendelian-randomization-with-applications-in-neurology
#14
REVIEW
Phillip H Allman, Inmaculada B Aban, Hemant K Tiwari, Gary R Cutter
Mendelian randomization studies have become increasingly common due to the maturation of genome-wide association studies and its potential to ascertain causal relationships. With the increasing use of this method comes the need for medical practitioners and clinicians to develop an understanding of its rationale, limitations, and interpretation. Mendelian randomization attempts to ascertain a causal relationship between some risk factor of interest and some outcome or disease of interest. It exploits Mendel's law on the random assortment of genetic variants...
June 20, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29957351/progressive-visual-function-impairment-as-the-predominant-symptom-of-the-transition-phase-to-secondary-progressive-multiple-sclerosis-a-case-report
#15
A Giordano, B Colombo, E G Spinelli, S Gelibter, S Guerrieri, L Leocani, G Comi, V Martinelli
BACKGROUND: No reliable indicators of the transition to the progressive course in multiple sclerosis (MS) have been identified so far. The main clinical feature of the progressive phase of MS is usually impairment of walking. Magnetic resonance imaging and optical coherence tomography have emerged recently as promising tools to assess increasing neurodegeneration and axonal loss in disease progression in MS. METHODS: <AbstractText Label="CASE REPORT" NlmCategory="METHODS"/> <AbstractText Label="RESULTS" NlmCategory="RESULTS">We report a case of progressive visual impairment as the dominant symptom in the transition to secondary progressive MS...
June 20, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29957350/heart-rate-variability-analysis-in-patients-with-multiple-sclerosis
#16
Ozbek Damla, Cincin Altug, Kahraman Koytak Pinar, Kepez Alper, Ince Gunal Dilek, Agan Kadriye
BACKGROUND: Multiple sclerosis can cause cardiovascular autonomic dysfunction. It is assumed that is caused by multiple demyelinating plaques localized in the brain stem and spinal cord. Previous studies have determined this using tilt table test, heart rate responses to Valsalva maneuver and deep breathing and heart rate variability analysis with 24 h Holter monitoring. However there is not a consensus regarding the presence of the relationship between autonomic dysfunction and severity of multiple sclerosis, type of multiple sclerosis and expanded disability status scale...
June 19, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30005355/patient-awareness-about-family-planning-represents-a-major-knowledge-gap-in-multiple-sclerosis
#17
Peter Vestergaard Rasmussen, Melinda Magyari, Julie Yoon Moberg, Mette Bøgelund, Ulla Fie Appel Jensen, Klaus Gregaard Madsen
BACKGROUND: The purpose of the survey was to assess the knowledge of family planning issues associated with disease modifying therapies (DMTs) among patients diagnosed with multiple sclerosis (MS). METHODS: 590 Danish MS patients responded to an online questionnaire about family planning in MS, collecting demographics, disease characteristics, disease modifying treatment, knowledge of potential teratogenic effects in DMTs, number of children, occurrence of unplanned pregnancies and outcome, and sources of information...
June 15, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29936326/high-intensity-interval-training-for-people-with-multiple-sclerosis-a-systematic-review
#18
REVIEW
Evan Campbell, Elaine H Coulter, Lorna Paul
BACKGROUND: Aerobic high intensity interval training (HIIT) is safe in the general population and more efficient in improving fitness than continuous moderate intensity training. The body of literature examining HIIT in multiple sclerosis (MS) is expanding but to date a systematic review has not been conducted. The aim of this review was to investigate the efficacy and safety of HIIT in people with MS. METHODS: A systematic search was carried out in September 2017 in EMBASE, MEDline, PEDro, CENTRAL and Web of Science Core collections using appropriate keywords and MeSH descriptors...
June 13, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29929093/time-to-consider-alternative-environmental-risk-factor-rather-than-ultra-violet-b-for-multiple-sclerosis
#19
LETTER
Seyed Aidin Sajedi
No abstract text is available yet for this article.
June 8, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29906666/real-life-persistence-and-tolerability-with-dimethyl-fumarate
#20
Tobias Sejbaek, Mads Nybo, Thor Petersen, Zsolt Illes
BACKGROUND: Dimethyl fumarate (DMF) has been registered for the treatment of relapsing-remitting multiple sclerosis (RRMS). Differences in tolerability between multiple sclerosis clinics in patients treated with DMF has not been examined. AIM: We examined real-world tolerability to DMF, and also compared adherence data between two MS clinics. METHODS: Adverse events (AE), discontinuation rates, and causes of discontinuation were investigated...
June 2, 2018: Multiple Sclerosis and related Disorders
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