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Multiple Sclerosis and related Disorders

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https://www.readbyqxmd.com/read/29136526/upbeat-nystagmus-is-a-useful-sign-in-the-regional-diagnosis-of-trigeminal-nerve-disorder-with-multiple-sclerosis
#1
Kiyotaka Nakamagoe, Naoki Tozaka, Seitaro Nohara, Rio Kawakami, Shiori Yamada, Tadachika Koganezawa, Akira Tamaoka
Trigeminal nerve disorder is an important neurological sign that is often seen with multiple sclerosis (MS). We investigated eye movements in three MS patients with trigeminal disorder due to pontine lesions near the trigeminal root entry zone (REZ). Upbeat nystagmus was observed in all MS patients with trigeminal REZ lesions. We conjecture that trigeminal nerve disorder and upbeat nystagmus appeared due to simultaneous damage to both the trigeminal nerve and the vestibulo-ocular reflex pathway. If upbeat nystagmus appears in MS patients exhibiting a trigeminal nerve disorder, such as trigeminal neuralgia, and paralysis, pontine lesions near the trigeminal REZ should be considered...
November 9, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29149698/ectrodactyly-in-a-chinese-patient-born-to-a-mother-with-neuromyelitis-optica-spectrum-disorder
#2
Yanyu Chang, Yaqing Shu, Xiaobo Sun, Chengfang Xu, Dan He, Ling Fang, Chen Chen, Xueqiang Hu, Allan Kermode, Wei Qiu
NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29149697/characteristics-of-motor-speech-phenotypes-in-multiple-sclerosis
#3
Jan Rusz, Barbora Benova, Hana Ruzickova, Michal Novotny, Tereza Tykalova, Jan Hlavnicka, Tomas Uher, Manuela Vaneckova, Michaela Andelova, Klara Novotna, Lucie Kadrnozkova, Dana Horakova
BACKGROUND: Motor speech disorders in multiple sclerosis (MS) are poorly understood and their quantitative, objective acoustic characterization remains limited. Additionally, little data regarding relationships between the severity of speech disorders and neurological involvement in MS, as well as the contribution of pyramidal and cerebellar functional systems on speech phenotypes, is available. METHODS: Speech data were acquired from 141 MS patients with Expanded Disability Status Scale (EDSS) ranging from 1 to 6...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29132035/brain-volume-in-early-ms-patients-with-and-without-igg-oligoclonal-bands-in-csf
#4
G Fenu, L Lorefice, V Sechi, L Loi, F Contu, F Cabras, G Coghe, J Frau, M A Secci, C Melis, L Schirru, G Costa, V Melas, M Arru, M A Barracciu, M G Marrosu, E Cocco
BACKGROUND: Oligoclonal bands of IgG (OB) are proposed as an early prognostic factor of the disease. Growing attention is directed towards brain volume evaluation as a possible marker of the severity of MS. Previous studies found that MS patients lacking OB have less brain atrophy. AIM: to evaluate a possible relationship between OB and cerebral volume in a cohort of early MS patients. METHODS: Inclusion criteria were: diagnosis of relapsing-remitting MS; CSF analysis and MRI acquired simultaneously and within 12 months from clinical onset...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29125969/psychiatric-comorbidities-and-suicidality-among-patients-with-neuromyelitis-optica-spectrum-disorders-in-argentina
#5
V C Fernández, N Alonso, L Melamud, A M Villa
BACKGROUND: Neuromyelitis optica is a relapsing inflammatory, secondarily demyelinating astrocytopathy that most commonly affects the optic nerves and the spinal cord. OBJECTIVE: This study aimed to evaluate the psychopathological profile, presence of current depression, and suicidality in patients with neuromyelitis optica spectrum disorders (NMOSD) in an Argentinean cohort, and compare these parameters to those in patients with multiple sclerosis (MS) and in healthy controls (HCs)...
November 7, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29125968/the-prevalence-of-anxiety-and-associated-factors-in-persons-with-multiple-sclerosis
#6
Tram Pham, Nathalie Jetté, Andrew G M Bulloch, Jodie M Burton, Samuel Wiebe, Scott B Patten
BACKGROUND: The prevalence of anxiety and its association with sociodemographic and clinical factors is not well characterized in those with multiple sclerosis (MS). We aimed to estimate the prevalence and examine associated factors of anxiety in persons with MS. METHODS: A cross-sectional analysis was conducted utilizing data from 244 participants from the Neurological Disease and Depression study. Anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS)...
November 7, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29128737/a-8-year-retrospective-cohort-study-comparing-interferon-%C3%AE-formulations-for-relapsing-remitting-multiple-sclerosis
#7
Marcello Moccia, Raffaele Palladino, Antonio Carotenuto, Francesco Saccà, Cinzia Valeria Russo, Roberta Lanzillo, Vincenzo Brescia Morra
BACKGROUND: Interferon-β has been approved for the treatment of relapsing-remitting (RR) multiple sclerosis (MS), whereas its efficacy in preventing long-term disability and conversion to secondary progressive (SP) MS is still debated. We aim to compare long-term clinical evolution of newly-diagnosed RRMS patients treated with different Interferon-β formulations. METHODS: 507 patients were included in the analysis and followed-up for 8.5 ± 3.9 years. 37.6% were treated with subcutaneous Interferon-β1a 44mcg, 33...
November 6, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29127856/acute-and-long-term-effects-of-fingolimod-on-heart-rhythm-and-heart-rate-variability-in-patients-with-multiple-sclerosis
#8
Ruken Özge Akbulak, Sina C Rosenkranz, Benjamin N Schaeffer, Hans O Pinnschmidt, Stephan Willems, Christoph Heesen, Boris A Hoffmann
BACKGROUND: Fingolimod can lead to increased risk of cardiac events such as bradycardia or atrioventricular (AV) block. OBJECTIVE: Evaluate acute and long-term effects of fingolimod on heart rhythm (HR), heart rate variability (HRV) and development of AV-blocks. METHODS: In 64 patients with relapsing-remitting multiple sclerosis Holter ECG monitoring (HEM) and HRV analysis were performed 24h before, six h during and 72h after initiation of fingolimod...
November 2, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29121513/psychiatric-morbidity-develops-after-onset-of-pediatric-multiple-sclerosis-a-danish-nationwide-population-based-study
#9
Magnus Spangsberg Boesen, Lau Caspar Thygesen, Peter Vilhelm Uldall, Frank Eriksson, Alfred Peter Born, Morten Blinkenberg, Nils Koch-Henriksen, Gorm Greisen, Melinda Magyari
BACKGROUND: Pediatric-onset multiple sclerosis (MS) affects life at a stage vital for social and educational achievements and psychiatric co-morbidity is common after MS onset. Few studies have examined psychiatric morbidity before MS onset. METHODS: In this nationwide study, detailed case ascertainment was performed in all children with pediatric MS, including chart review. For each MS patient, we selected five controls using density sampling from the entire Danish population, matching controls to children with MS by sex and birthdate...
October 31, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29112939/serious-games-for-arm-rehabilitation-of-persons-with-multiple-sclerosis-a-randomized-controlled-pilot-study
#10
Johanna Jonsdottir, Rita Bertoni, Michael Lawo, Angelo Montesano, Thomas Bowman, Silvia Gabrielli
OBJECTIVES: The feasibility and preliminary evidence for efficacy of a serious games platform compared to exergame using the Wii for arm rehabilitation in persons with multiple sclerosis (MS) was investigated. METHODS: A pilot single-blind randomized (2:1) controlled in clinic trial was carried out. Sixteen persons with MS participated (age years 56.8 (SD 12.3), MS-onset years 19.4 (SD 12.3), EDSS 6.5). Ten participants used a serious games platform (Rehab@Home) while 6 participants played with the commercial Wii platform, for four weeks (40min, 12 sessions/4 weeks)...
October 28, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29100046/vaccinia-related-kinase-2-vrk2-expression-in-neurological-disorders-schizophrenia-epilepsy-and-multiple-sclerosis
#11
Tahereh Azimi, Soudeh Ghafouri-Fard, Mir Davood Omrani, Mehrdokht Mazdeh, Shahram Arsang-Jang, Arezou Sayad, Mohammad Taheri
BACKGROUND: Schizophrenia (SCZ), epilepsy and Multiple Sclerosis (MS) are neurological disorders with increasing prevalence disturb the patients' lives and are regarded as burdens to the society. As multifactorial disorders, genetic susceptibility factors are involved in their pathogenesis. The Vaccinia-Related Kinase 2 (VRK2) gene codes for a serine threonine kinase recently reported to be contributed in the pathogenesis of some neurological disorders. In the present case-control study we compared the VRK2 gene expression in peripheral blood samples from SCZ, epilepsy and MS patients with normal subjects...
October 25, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29100048/novel-candidate-genes-of-the-park7-interactome-as-mediators-of-apoptosis-and-acetylation-in-multiple-sclerosis-an-in-silico-analysis
#12
George D Vavougios, Sotirios G Zarogiannis, Karen Angeliki Krogfelt, Konstantinos Gourgoulianis, Dimos Dimitrios Mitsikostas, Georgios Hadjigeorgiou
BACKGROUND: currently only 4 studies have explored the potential role of PARK7's dysregulation in MS pathophysiology Currently, no study has evaluated the potential role of the PARK7 interactome in MS. OBJECTIVE: The aim of our study was to assess the differential expression of PARK7 mRNA in peripheral blood mononuclears (PBMCs) donated from MS versus healthy patients using data mining techniques. METHODS: The PARK7 interactome data from the GDS3920 profile were scrutinized for differentially expressed genes (DEGs); Gene Enrichment Analysis (GEA) was used to detect significantly enriched biological functions...
October 24, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29100047/prevalence-of-neuromyelitis-optica-spectrum-disorder-in-the-multi-ethnic-penang-island-malaysia-and-a-review-of-worldwide-prevalence
#13
Jyh Yung Hor, Thien Thien Lim, Yuen Kang Chia, Yee Ming Ching, Chun Fai Cheah, Kenny Tan, Han Bing Chow, Masita Arip, Gaik Bee Eow, P E Samuel Easaw, M Isabel Leite
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) occurs worldwide in all ethnicities. Recently, population-based studies have shown that NMOSD is more common among non-White populations. There is scarce data about NMOSD prevalence in South East Asian populations. METHODS: (1) A population-based study was undertaken to estimate NMOSD prevalence in the multi-ethnic Penang Island, Malaysia, comprising Chinese, Malays, and Indians. Medical records of NMOSD patients followed up at the Penang General Hospital (the neurology referral centre in Penang Island) were reviewed...
October 21, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29107207/association-of-serum-gamma-glutamyltransferase-and-c-reactive-proteins-with-neuromyelitis-optica-and-multiple-sclerosis
#14
Yaqing Shu, Rui Li, Wei Qiu, Yanyu Chang, Xiaobo Sun, Ling Fang, Chen Chen, Yu Yang, Zhengqi Lu, Xueqiang Hu, Allan G Kermode
BACKGROUND: Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown. METHODS: We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Serum GGT and CRP levels were measured in 106 NMO patients, 87 MS patients, 79 patients with non-inflammatory neurological diseases (Parkinson disease) and 80 healthy controls (HC)...
September 20, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141832/editors-welcome
#15
EDITORIAL
Emmanuelle Waubant, Gavin Giovannoni, Chris Hawkes, Fred Lublin
No abstract text is available yet for this article.
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141831/long-term-follow-up-of-a-randomized-study-of-combination-interferon-and-glatiramer-acetate-in-multiple-sclerosis-efficacy-and-safety-results-up-to-7-years
#16
Fred D Lublin, Stacey S Cofield, Gary R Cutter, Tarah Gustafson, Stephen Krieger, Ponnada A Narayana, Flavia Nelson, Amber R Salter, Jerry S Wolinsky
BACKGROUND: To report the long-term results of the blinded extension phase of the randomized, controlled study of the combined use of interferon beta-1a (IFN) 30μg IM weekly and glatiramer acetate (GA) 20mg daily compared to each agent alone in relapsing-remitting multiple sclerosis (RRMS). METHODS: 1008 RRMS patients were followed on protocol until the last participant enrolled completed 3 years, allowing some subjects to be followed for up to 7 years. The primary endpoint was reduction in annualized relapse rate...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141830/post-herpes-zoster-infection-neuromyelitis-optica-spectrum-disorder
#17
Thomas Mathew, Kurian Thomas, Sonia Shivde, Shruthi Venkatesh, Smitha Mary Rockey
Neuromyelitis optica is a severe autoimmune demyelinating disease; however, the trigger for autoimmunity in an individual patient is unclear. Here, we report the case of a 48 year old female presenting with longitudinally extensive transverse myelitis in the cervical region of the spinal cord two weeks post herpes zoster infection in right C6 dermatome. Though post herpetic myelitis was provisionally diagnosed, serological evaluation revealed aquaporin-4 antibody positivity, confirming the diagnosis of neuromyelitis optica spectrum disorder...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141829/cerebral-cortical-encephalitis-followed-by-recurrent-cns-demyelination-in-a-patient-with-concomitant-anti-mog-and-anti-nmda-receptor-antibodies
#18
Lei Zhou, Jingzi ZhangBao, Haiqing Li, Xiaoyang Li, Yongheng Huang, Min Wang, Chongbo Zhao, Jiahong Lu, Chuanzhen Lu, Yuxin Li, Chao Quan
We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141828/alternative-diagnoses-in-patients-referred-to-specialized-centers-for-suspected-ms
#19
B I Yamout, S J Khoury, N Ayyoubi, H Doumiati, M Fakhreddine, S F Ahmed, H Tamim, J Y Al-Hashel, R Behbehani, R Alroughani
OBJECTIVES: The aim of this study is to explore the frequency, type, and predictors of alternative diagnoses among patients referred with a recent diagnosis of multiple sclerosis (MS) to two specialized MS centers in the Middle East. METHODS: This is a retrospective review of a prospectively followed cohort of MS patients at 2 University specialized MS centers. All patients referred for MS were included. The final diagnosis was recorded and demographic, clinical, laboratory, electrophysiological and radiological variables were collected...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141827/a-nmosd-case-with-multifocal-nervous-system-involvement-in-a-single-attack
#20
LETTER
Tuba Tanyel, Zerrin Karaaslan, Handan Misirli, Mehmet Gencer, Erdem Tüzün, Recai Türkoğlu
No abstract text is available yet for this article.
November 2017: Multiple Sclerosis and related Disorders
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