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Multiple Sclerosis and related Disorders

Paola Perini, Francesca Rinaldi, Marco Puthenparampil, Michela Marcon, Francesco Perini, Paolo Gallo
BACKGROUND: Dimethyl fumarate (DMF) is approved as first line therapy for relapsing-remitting multiple sclerosis (RRMS). In some (3%) patients, DMF induces a marked lymphopenia. Herpes simplex encephalitis (HSE) may occur in lymphopenic subjects under treatment with immune-suppressive drugs. CASE PRESENTATION: We report a case of a 39-year-old female patient with RRMS that developed HSE temporally associated with a marked and sudden drop in lymphocyte count, from 1200/µl to 600/µl, in the peripheral blood...
September 11, 2018: Multiple Sclerosis and related Disorders
Viktoria Papp, Annika R Langkilde, Morten Blinkenberg, Karen Schreiber, Poul Erik Hyldgaard Jensen, Finn Sellebjerg
BACKGROUND: Anti-myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) can be found in different immune-mediated inflammatory CNS disorders. The full range of clinical manifestations may not have been fully discovered yet. METHODS: In a cross-sectional study 184 adults (age ≥ 16) were tested for anti-MOG antibody (Ab) with a cell-based assay. To define the relevant target population for anti-MOG antibody testing in a neurology clinic, we divided the entire study population based on the presenting symptoms and classified cases followed for multiple sclerosis (MS) according to the clinical features and response to disease-modifying therapy...
September 11, 2018: Multiple Sclerosis and related Disorders
C Lapucci, F Gualandi, M Mikulska, S Palmeri, G Mancardi, A Uccelli, A Laroni
BACKGROUND: Alemtuzumab is a monoclonal antibody approved for relapsing-remitting multiple sclerosis (RRMS). The only report of Serum Sickness (SS) in a MS patient occurred during treatment with natalizumab. Non-protein drugs, such as some antibiotics, may induce "SS-like" reactions (SSLR), whose clinical and laboratory features may partially overlap with the traditional SS. OBJECTIVE: To report a case of SS/SSLR in a RRMS patient treated with alemtuzumab...
September 11, 2018: Multiple Sclerosis and related Disorders
Bahadır Konuskan, Mirac Yildirim, Rahsan Gocmen, Tuncay Derya Okur, Ipek Polat, Huseyin Kilic, Sema Saltik, Zeynep Ozturk, Kivilcim Gucuyener, Sakir Altunbasak, Tamer Celik, Gulsen Kose, Arzu Yilmaz, Mustafa Komur, Hulya Kayilioglu, Banu Anlar
BACKGROUND: Knowledge has been expanding on myelin oligodendrocyte glycoprotein (MOG) antibody-associated central nervous system disorders. We delineate the clinical and paraclinical findings and outcome of our pediatric patients with MOG antibody seropositive disease. METHODS: We retrospectively analyzed the clinical presentation, cerebrospinal fluid findings, magnetic resonance imaging (MRI) studies, course and outcome of children seropositive for anti-MOG IgG...
September 10, 2018: Multiple Sclerosis and related Disorders
Antonio Cortese, Antonella Conte, Gina Ferrazzano, Eleonora Sgarlata, Enrico Millefiorini, Marco Frontoni, Alfredo Berardelli
BACKGROUND: Photophobia has never been investigated in MS. METHODS: In this pilot study we used photosensitivity questionnaire assessment (PAQ) to evaluate tolerability to light in 73 MS patients and 62 healthy controls. RESULTS: We identified a lower PAQ score and a higher number of photophobic subjects in MS than in controls. Moreover, clinical disability or previous optic neuritis did not predict the photosensitivity profile. CONCLUSION: Further studies to investigate the pathophysiological mechanisms underlying photophobia in MS are needed...
September 8, 2018: Multiple Sclerosis and related Disorders
V Cimino, C G Chisari, G Raciti, A Pappalardo, M Zappia, F Patti
BACKGROUND: The computerized stabilometric platform can be used and privileged over clinical scales, as self-administered questionnaires to asses postural control and balance evaluation in Multiple sclerosis (MS). Aim of our study was to evaluate static postural control assessed by Neurocom Balance Manager® through the modified Clinical Test of Sensory Interaction on Balance (mCTSIB) in relapsing-remitting MS (RRMS), progressive MS (PMS) and CIS, compared to healthy controls (HC). METHODS: We screened MS patients consecutively referring to our MS Center at University of Catania, during July 2013-June 2014 diagnosed as CIS, RRMS and PMS...
September 8, 2018: Multiple Sclerosis and related Disorders
Anastasie M Dunn-Pirio, Christopher Eckstein
Schilder's disease is a rare and aggressive central nervous system demyelinating disorder that is typically monophasic and steroid responsive. Here, we present an unusual case of a teenager with Schilder's disease who was treated with corticosteroids and had a clinical and radiographic recurrence nearly one year after the initial presentation.
September 5, 2018: Multiple Sclerosis and related Disorders
Lommers Emilie, Depierreux Frédérique, Hansen Isabelle, Dive Dominique, Maquet Pierre
Tumor necrosis factor α (TNFα) inhibitors are highly effective and a therapeutic choice for several inflammatory diseases. Their broad and long-term use is associated with a growing number of paradoxical autoimmune events including demyelinating lesions of the central nervous system (CNS). We report and discuss a case of neuromyelitis optica spectrum disorder (NMOSD) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG1) following anti-TNFα therapy for a pustular psoriasis.
August 31, 2018: Multiple Sclerosis and related Disorders
Rita Bertoni, Johanna Jonsdottir, Peter Feys, Ilse Lamers, Davide Cattaneo
BACKGROUND: Gait velocity influences the ability of a person to move in different outdoor or indoor contexts and has accordingly been classified through the Modified Functional Walking Categories (MFWC). Community ambulation in persons with multiple sclerosis (PwMS) may give information on their social and productive participation, as well as independence in household activities. OBJECTIVES: To investigate factors associated with walking and mobility restrictions as classified by the Modified Functional Walking Categories (MFWC) and analyze the influence of disease characteristics, demographical and walking factors on participation in PwMS...
August 31, 2018: Multiple Sclerosis and related Disorders
Mohamed AlKhaja, Abdulaziz Abanmy, Ahmed AlKhdairi, Sami AlRasheedi, Hazza AlZahrani, Mona AlKhawajah
Increasing evidence has emerged lately regarding the use of autologous hematopoietic stem cell transplantation (HSCT) in the treatment of aggressive multiple sclerosis (MS). However, data is scarce regarding the use of allogenic HSCT in treating MS. We present a 42 years old male with aplastic anemia who underwent allogenic HSCT for severe aplastic anemia. This patient was diagnosed with primary progressive multiple sclerosis (PPMS) one-year post transplant and had to undergo a second HSCT due to his hematological disorder...
August 31, 2018: Multiple Sclerosis and related Disorders
Winda Kusumadewi, Darma Imran, Fiastuti Witjaksono, Trevino A Pakasi, Ahmad Irwan Rusmana, David Pangeran, Sarah Shafa Marwadhani, Kartika Maharani, Riwanti Estiasari
BACKGROUND: Vitamin D deficiency is commonly found in multiple sclerosis (MS) and Neuromyelitis Optic (NMO) patients and can impair the immunological status. As a tropical country, Indonesia has a lot of sunshine throughout the year as a source of vitamin D. The aim of this study was to evaluate and compare the serum vitamin D-25(OH) level in Indonesian MS and NMO patients to healthy individuals. METHODS: A cross-sectional study was conducted in Dr. Cipto Mangunkusumo General Hospital Jakarta from November 2016 to May 2017...
August 31, 2018: Multiple Sclerosis and related Disorders
Massimo Pieri, Rossella Zenobi, Maria Morello, Marianna Storto, Fabio Buttari, Diego Centonze, Sergio Bernardini, Mariarita Dessi
BACKGROUND: Multiple sclerosis (MS) is a chronic multifactorial inflammatory and neurodegenerative disease of the central nervous system (CNS). The identification of biomarkers with good diagnostic and prognostic power is of great importance for monitoring and treating MS patients. METHODS: We analyzed serum and cerebrospinal fluid of 228 patients, with different neurological disorders and with MS to confirm our previous results and determine a possible gender difference of kFLC Index cut-off...
August 30, 2018: Multiple Sclerosis and related Disorders
Xinghua Xu, Sumin Chi, Qun Wang, Chengxin Li, Bainan Xu, Jun Zhang, Xiaolei Chen
BACKGROUND: Several monoclonal antibodies have been licensed for relapsing remitting multiple sclerosis (RRMS). It is still unclear which treatment regimen should be recommended due to the lack of head-to-head randomized controlled trials (RCTs). This study aims to investigate the relative efficacy and safety of existing monoclonal antibody therapies in treating RRMS. METHODS: We searched PubMed, Embase, and the Cochrane Library for RCTs of monoclonal antibodies for treatment of RRMS...
August 29, 2018: Multiple Sclerosis and related Disorders
Alejandro Ruiz-Argüelles, Mariana A Méndez-Huerta, Claudia D Lozano, Guillermo J Ruiz-Argüelles
BACKGROUND: Dysglycemia and adiposity have been related to disability in patients with multiple sclerosis. The objective of this work was to determine the prevalence and characteristics of insulin resistance in patients with multiple sclerosis using the metabolomics Quantose score. METHODS: A total of 64 patients were accrued in the study. A blood sample was drawn to estimate the Quantose score, which is derived from fasting measurements of insulin, α-hydroxybutyrate, linoleoyl-glycerophosphocholine, and oleate, three nonglucose metabolites shown to correlate with insulin-stimulated glucose disposal...
August 25, 2018: Multiple Sclerosis and related Disorders
Benjamin W Ewanchuk, Marjan Gharagozloo, Evelyn Peelen, Lara A Pilutti
INTRODUCTION: Vascular comorbidities are prevalent among people with multiple sclerosis (MS) and have adverse disease-related consequences. In the general population, physical activity (PA) and exercise training have proven beneficial at all levels of vascular disease risk management. People with MS exhibit particularly low rates of PA; therefore, PA represents a modifiable health behavior for potentially managing vascular comorbidity risk in MS, and in turn, reducing disease burden. However, points of evidence justifying such an approach have yet to be summarized...
August 24, 2018: Multiple Sclerosis and related Disorders
Kanako Nakazawa, Takamasa Noda, Kanako Ichikura, Tomoko Okamoto, Yuji Takahashi, Takashi Yamamura, Kazuyuki Nakagome
BACKGROUND: Depression and anxiety are common in multiple sclerosis (MS) and recently, studies on these symptoms in neuromyelitis optica spectrum disorder (NMOSD) are increasing. Previous studies suggest that these symptoms have negative effects on the quality of life. Resilience has garnered more interest as one of the protective factors that works to prevent psychiatric symptoms in past decades. There exist a few studies, however, regarding the effects of resilience on these psychiatric symptoms in MS/NMOSD...
August 24, 2018: Multiple Sclerosis and related Disorders
Richard Salazar, Tiara Hypolite, Eric Bixby, Alex Nguyen
No abstract text is available yet for this article.
August 24, 2018: Multiple Sclerosis and related Disorders
Ibrahim Abdollahpour, Saharnaz Nedjat, Yahya Salimi, Rahmatollah Moradzadeh, Mohammad Ali Mansournia, Mohammad Ali Sahraian, Mostafa Shokoohi
BACKGROUND: Evidence on the association between socioeconomic status (SES) and multiple sclerosis (MS) is inconsistent. We examined the association of several indicators of SES with MS in an Iranian population. METHODS: We conducted a population-based incident case-control study with 547 incident cases and 1057 general population controls in Iran, 2015. Data was collected using telephone interviews and indicators of SES i.e. parental education, and household SES during adolescence using asset variables...
August 23, 2018: Multiple Sclerosis and related Disorders
Uwe Martin Pommerich, John Brincks, Marie Ernst Christensen
BACKGROUND: Fatigue is considered the most common symptom of persons with multiple sclerosis MS (pwMS), occurring in up to 90% of the patients at some point with two-thirds of pwMS experience fatigue as their most disturbing symptom. Pharmacological treatment options for MS-related fatigue show only limited and contradicting results. Consequently, many pwMS search for alternative options to control the symptom. A considerable interest in dietary interventions as a means of MS symptom management has advanced in the MS community...
August 21, 2018: Multiple Sclerosis and related Disorders
Ridvan Aktan, Sevgi Ozalevli, Serkan Ozakbas
OBJECTIVE: The aim of the study was to investigate the effects of smoking on respiratory symptoms and functional levels by questioning use of cigarette in Multiple Sclerosis (MS) patients. METHODS: A questionnaire was sent via e-mail to the 135 MS patients, who clinically diagnosed with MS and EDSS score was determined.Perceived dyspnea was assessed by the mMRC scale.The severity of dyspnea and fatigue perceived during rest and effort was assessed by the mBORG scale...
August 17, 2018: Multiple Sclerosis and related Disorders
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