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Multiple Sclerosis and related Disorders

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https://www.readbyqxmd.com/read/28755685/editors-welcome
#1
EDITORIAL
Chris Hawkes, Gavin Giovannoni, Fred Lublin, Emmanuelle Waubant
No abstract text is available yet for this article.
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755684/epstein-barr-virus-and-multiple-sclerosis-updating-pender-s-hypothesis
#2
REVIEW
Martin Laurence, Julián Benito-León
Substantial epidemiological evidence supports the involvement of the Epstein-Barr virus (EBV) in multiple sclerosis (MS). Mechanisms through which EBV may increase MS risk are reviewed here. Most individuals contract EBV in early childhood yet only develop MS in early adulthood, by which time EBV has been latent for decades. When latent, EBV is confined to a minute subset of memory B cells: about 1000 cells in peripheral blood and 500,000 cells in the lymphoid system, mainly in the mouth. Reactivation of EBV in the central nervous system (CNS) has been proposed as a cause of MS...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755683/sulbutiamine-shows-promising-results-in-reducing-fatigue-in-patients-with-multiple-sclerosis
#3
Serhan Sevim, Hakan Kaleağası, Bahar Taşdelen
BACKGROUND: Fatigue is the most frequent and often debilitating symptom for patients with multiple sclerosis (MS). There are no available effective therapies for fatigue associated with MS, and it is unclear whether a successful therapy of MS leads to clinical improvement. Sulbutiamine is a lipophilic compound that crosses the blood-brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. Whereas several clinical trials have demonstrated the beneficial effects of sulbutiamine in patients with asthenia, there have been no reports on the effects of sulbutiamine on fatigue in patients with MS...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755682/the-effect-of-exercise-training-in-adults-with-multiple-sclerosis-with-severe-mobility-disability-a-systematic-review-and-future-research-directions
#4
REVIEW
Thomas Edwards, Lara A Pilutti
INTRODUCTION: There is evidence for the benefits of exercise training in persons with multiple sclerosis (MS). However, these benefits have primarily been established in individuals with mild-to-moderate disability (i.e., Expanded Disability Status Scale [EDSS] scores 1.0-5.5), rather than among those with significant mobility impairment. Further, the approaches to exercise training that have been effective in persons with mild-to-moderate MS disability may not be physically accessible for individuals with mobility limitations...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755681/ebv-and-ms-major-cause-minor-contribution-or-red-herring
#5
REVIEW
Sean Burnard, Jeannette Lechner-Scott, Rodney J Scott
Multiple Sclerosis (MS) is a chronic neurological disease with genetic and environmental risk factors. Epstein Barr-Virus (EBV) has been closely associated with MS but with a significant amount of conflicting evidence. Some of the evidence for EBV involvement in MS includes: almost 100% of MS patients showing past EBV infection, an association with Infectious Mononucleosis (acute EBV infection), higher titres of EBV antibodies associated with an increased risk of MS development, and an overall altered immune response to EBV found in peripheral blood and the CNS of MS patients...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755680/capillary-leak-syndrome-in-neuromyelitis-optica-treated-with-rituximab
#6
Ignacio Fuentes Fernandez, Rocio Hernandez-Clares, Ester Carreón Guarnizo, Jose E Meca Lallana
61-year-old woman with Neuromyelitis optica (NMO) diagnosis treated with rituximab was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein. She developed a multiple organ failure and died three hours later. We diagnosed the patient as having capillary leak syndrome (CLS). CLS is a very rare condition caused by unexplained episodic capillary hyperpermeability, which can be idiopathic or secondary to some conditions like infection, malignant disease and some drugs like monoclonal antibodies...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755679/effect-of-walking-on-sand-on-gait-kinematics-in-individuals-with-multiple-sclerosis
#7
Maayken E L van den Berg, Christopher J Barr, James V McLoughlin, Maria Crotty
BACKGROUND: Walking in the real-world involves negotiating challenging or uneven surfaces, including sand. This can be challenging for people with Multiple Sclerosis (PWMS) due to motor deficits affecting the lower extremities. The study objective was to characterise kinematic gait adaptations made by PWMS when walking on sand and describe any immediate post-adaptation effects. METHODS: 17 PWMS (mean age 51.4 ± 5.5, Disease Steps 2.4 ± 1.0), and 14 age-and gender matched healthy adults (HA) took part in a case-control study...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755678/cognitive-impairment-in-chinese-iidds-revealed-by-moca-and-p300
#8
Qiuming Zeng, Xiaohua Dong, Chunyun Ruan, Bo Hu, Binting Zhou, Yuanyuan Xue, Yu Liu, Huan Yang
To investigate the value of MoCA and auditory P300 as a cognitive assessment tool in chinese idiopathic inflammatory-demyelinating diseases (IIDDs), eighty three consecutive patients with IIDDs and thirteen sex- and age-matched healthy controls were recruited in the study. MMSE, MoCA and auditory P300 potential were administrated to each participant. The percentage of cognitive impairment in IIDDs patients was 24.1% by using MMSE, while the percentage was 81.9% by using MoCA. The majority of IIDDs participants had MMSE scores in the normal range...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641776/the-field-hypothesis-rebound-activity-after-stopping-disease-modifying-therapies
#9
EDITORIAL
Gavin Giovannoni, Chris Hawkes, Emmanuelle Waubant, Fred Lublin
No abstract text is available yet for this article.
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641775/is-toxoplasma-gondii-infection-protective-against-multiple-sclerosis-risk
#10
Asli Koskderelioglu, Ilhan Afsar, Bayram Pektas, Muhtesem Gedizlioglu
BACKGROUND: Parasitic infections may play a protective role in neurodegenative diseases. OBJECTıVE: To determine the association between Toxoplasma gondii (T. gondii) infection and Multiple Sclerosis (MS). METHODS: One hundred fifteen patients with MS were included in the study. Sixty age and gender-matched healthy subjects were recruited as controls. Subjects were assessed for clinical and demographic parameters. The presence of specific IgG antibodies against T...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641774/membranous-nephropathy-with-neuromyelitis-optica-spectrum-disorder
#11
Xiangling Li, YanQiang Wang
Membranous nephropathy (MN) accompanying Neuromyelitis optica spectrum disorders (NMOSD) has rarely been described previously. We recently presented a 45-year-old Chinese male presenting with recurrent lower extremity pitting edema, or eyelid edema, proteinuria and hyperlipidemia. especially intractable hiccup and vomiting, painful tonic spasm (PTS) as the revealing symptom of a demyelinating disorder of central nervous system. The kindey biopsy specimen showed MN stage 2. Serological testing revealed antibodies AQP4, MRI head and spine revealed medulla oblongata and C1-C2 cervical vertebra lesions...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641773/incidence-of-tonic-spasms-as-the-initial-presentation-of-pediatric-multiple-sclerosis-in-slovenia
#12
Neli Bizjak, Damjan Osredkar, Nuška Pečarič Meglič, Mirjana Perković Benedik
Tonic spasms (TS) are involuntary movement patterns that can present in patients with multiple sclerosis (MS). They have been first described decades ago, but are frequently missed and misdiagnosed, particularly in the pediatric MS patients and if appearing ahead of hallmark neurological signs and symptoms of MS. Slovenia is a country with the population of about 2 million people. In the years from 1992 to 2016, we have treated 57 sequential pediatric patients with MS at our hospital, which is the only tertiary medical institution for treating children with MS in the country...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641772/susac-syndrome-a-differential-diagnosis-of-white-matter-lesions
#13
Mariano Marrodan, Jorge Correale, Lucas Alessandro, Mariela Amaya, Maria Eugenia Fracaro, Alejandro Alfredo Köhler, Marcela Fiol
INTRODUCTION: Susac Syndrome is an autoimmune endotheliopathy affecting capillaries and precapillary arterioles of the brain, inner ear and retina. The classic symptom triad includes visual disturbances, hypoacusia, and encephalopathy, but is rarely fully manifest at onset. The syndrome typically follows an active fluctuating monophasic course. Typical imaging findings on brain magnetic resonance show central fiber microischemias/microinfarctions of the corpus callosum known as "snow balls", as well as lineal infarcts and upper callosal fiber involvement...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641771/fatigue-in-multiple-sclerosis-is-it-related-to-cytokines-and-hypothalamic-pituitary-adrenal-axis
#14
Aylin Akcali, Fatma Zengin, Sefika Nur Aksoy, Orhan Zengin
BACKGROUND: Fatigue is a common symptom of Multiple Sclerosis (MS) that diminishes the quality of life of patients, but its exact mechanism remains poorly understood. There is not a generally adopted scale to determine MS fatigue. Studies that investigated physiopathology of fatigue symptom have shown dysregulation of hypothalamic-pituitaryadrenal (HPA) axis. In the current study, we aimed to compare the results obtained with two separate scales, namely the Fatigue Severity Scale (FSS) and the Neurological Fatigue Index-Multiple Sclerosis (NFI-MS), and assess the relationship between fatigue and serum IL-1β, TNF-α, IL-35, IL-2, IL-10, ACTH, cortisol, α-MSH, β-MSH, γ-MSH and CLIP (Corticotropinlike intermediate lobe peptide) in MS patients categorized as fatigued and non-fatigued on the basis of FSS scores...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641770/does-vagotomy-protect-against-multiple-sclerosis
#15
Jens Sundbøll, Erzsébet Horváth-Puhó, Kasper Adelborg, Elisabeth Svensson
OBJECTIVES: To examine the association between vagotomy and multiple sclerosis. METHODS: We conducted a matched cohort study of all patients who underwent truncal or super-selective vagotomy and a comparison cohort, by linking Danish population-based medical registries (1977-1995). Hazard ratios (HRs) for multiple sclerosis, adjusting for potential confounders were computed by means of Cox regression analysis. RESULTS: Median age of multiple sclerosis onset corresponded to late onset multiple sclerosis...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641769/reduction-of-pk11195-uptake-observed-in-multiple-sclerosis-lesions-after-natalizumab-initiation
#16
Ulrike W Kaunzner, Yeona Kang, Elizabeth Monohan, Paresh J Kothari, Nancy Nealon, Jai Perumal, Timothy Vartanian, Amy Kuceyeski, Shankar Vallabhajosula, P David Mozley, Claire S Riley, Stephen M Newman, Susan A Gauthier
OBJECTIVE: The objective of this study is to longitudinally analyze the uptake of [(11)C]PK11195-PET in multiple sclerosis patients after 3 and 6 months of natalizumab treatment. METHODS: Eighteen MS patients, starting treatment with monocloncal anti-VLA-4, were enrolled in a longitudinal PK-PET study. PK uptake was quantified by volume of distribution (VT) calculation using image-derived input function at baseline, 3 and 6 months. Pharmacokinetic quantification was done using a segmented MRI, and selected areas included white matter, gadolinium enhancing lesions, non-enhancing lesions, cortical grey matter and thalamus...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641768/disease-reactivation-following-fingolimod-withdrawal-in-multiple-sclerosis-two-case-reports
#17
Benedetta Forci, Alice Mariottini, Claudia Mechi, Luca Massacesi, Anna Repice
BACKGROUND: Severe multiple sclerosis reactivation following second line treatment withdrawal, defined "rebound syndrome", is becoming a prominent issue to consider when deciding to discontinue a treatment. In particular disease recurrence after cessation of fingolimod is actually poorly characterized as to date, only case reports and small case series have been described. CASE PRESENTATION: We herewith describe 2 cases of severe disease reactivation associated to a high number of brain gadolinium enhancing lesions at magnetic resonance imaging (MRI) despite high dose steroid treatment, observed a few weeks after cessation of fingolimod administration, causing a substantial and persistent worsening of patient disability that required long term hospitalization...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641767/prehistoric-enemies-within-the-contribution-of-human-endogenous-retroviruses-to-neurological-diseases-meeting-report-second-international-workshop-on-human-endogenous-retroviruses-and-disease-washington-dc-march-13th-and-14th-2017
#18
David Kremer, Robert Glanzman, Anthony Traboulsee, Avindra Nath, Laurent Groc, Marc Horwitz, Peter Göttle, Hervé Perron, Julian Gold, Hans-Peter Hartung, Patrick Küry
The Second International Workshop on Human Endogenous Retroviruses and Disease, Washington DC, March 13-14 2017 brought together international basic and clinical scientists investigating the involvement of human endogenous retroviruses (HERVs) in complex human diseases.
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641766/amyloid-pet-in-pseudotumoral-multiple-sclerosis
#19
Jordi A Matías-Guiu, María Nieves Cabrera-Martín, Ana Cortés-Martínez, Vanesa Pytel, Teresa Moreno-Ramos, Celia Oreja-Guevara, José Luis Carreras, Jorge Matías-Guiu
BACKGROUND: Pseudotumoral multiple sclerosis is a rare form of demyelinating disease of the central nervous system. Positron emission tomography (PET) using amyloid-tracers has also been suggested as a marker of damage in white matter lesions in multiple sclerosis due to the nonspecific uptake of these tracers in white matter. METHOD: We present the case of a 59 year-old woman with a pathological-confirmed pseudotumoral multiple sclerosis, who was studied with the amyloid tracer (18)F-florbetaben...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641765/investigation-of-the-prognostic-value-of-adipokines-in-multiple-sclerosis
#20
Arzu Çoban, Berna Düzel, Erdem Tüzün, Yusuf Tamam
BACKGROUND: Adipokines may be involved in multiple sclerosis (MS) as well as other inflammatory diseases. This study aimed to analyze the value of serum adipokine levels as biomarkers in determining the clinical progression of MS. METHODS: A total of 90 subjects including 40 healthy individuals and 50 MS patients [24 with classical clinical course of MS (C-MS), 26 with benign MS (B-MS)] were recruited for this study. The levels of serum adipokines and inflammatory mediators were measured using immunoassay methods...
July 2017: Multiple Sclerosis and related Disorders
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