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Multiple Sclerosis and related Disorders

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https://www.readbyqxmd.com/read/28283115/editors-welcome
#1
EDITORIAL
Chris Hawkes, Gavin Giovannoni, Fred Lublin, Emmanuelle Waubant
No abstract text is available yet for this article.
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283114/the-varieties-of-psychosis-in-multiple-sclerosis-a-systematic-review-of-cases
#2
REVIEW
Carlos R Camara-Lemarroy, Beatriz E Ibarra-Yruegas, Rene Rodriguez-Gutierrez, Idanis Berrios-Morales, Carolina Ionete, Peter Riskind
OBJECTIVES: Multiple Sclerosis (MS) is known to be associated with a wide range of psychiatric symptoms, particularly with affective disorders. However, a link to psychotic disorders has not been fully established. METHODS: A systematic review of the PubMed/MEDLINE database was performed to identify cases of MS presenting with psychotic symptoms. Variables analyzed included patient demographics, clinical presentation, imaging characteristics and treatment. RESULTS: Ninety-one cases were identified...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283113/discontinuation-of-disease-modifying-treatments-in-middle-aged-multiple-sclerosis-patients-first-line-drugs-vs-natalizumab
#3
Jan Fagius, Amalia Feresiadou, Elna-Marie Larsson, Joachim Burman
BACKGROUND: Several disease-modifying drugs (DMD) are available for the treatment of MS, and most patients with relapsing-remitting disease are currently treated. Data on when and how DMD treatment can be safely discontinued are scarce. METHODS: Fifteen MS patients, treated with natalizumab for >5 years without clinical and radiological signs of inflammatory disease activity, suspended treatment and were monitored with MRI examinations and clinical follow-up to determine recurrence of disease activity...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283112/should-we-rebrand-multiple-sclerosis-a-dementia
#4
Gavin Giovannoni
No abstract text is available yet for this article.
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283111/is-multiple-sclerosis-a-length-dependent-central-axonopathy-the-case-for-therapeutic-lag-and-the-asynchronous-progressive-ms-hypotheses
#5
REVIEW
Gavin Giovannoni, Gary Cutter, Maria Pia-Sormani, Shibeshih Belachew, Robert Hyde, Harold Koendgen, Volker Knappertz, Davorka Tomic, David Leppert, Robert Herndon, Claudia A M Wheeler-Kingshott, Olga Ciccarelli, David Selwood, Elisabetta Verdun di Cantogno, Ali-Frederic Ben-Amor, Paul Matthews, Daniele Carassiti, David Baker, Klaus Schmierer
Trials of anti-inflammatory therapies in non-relapsing progressive multiple sclerosis (MS) have been stubbornly negative except recently for an anti-CD20 therapy in primary progressive MS and a S1P modulator siponimod in secondary progressive MS. We argue that this might be because trials have been too short and have focused on assessing neuronal pathways, with insufficient reserve capacity, as the core component of the primary outcome. Delayed neuroaxonal degeneration primed by prior inflammation is not expected to respond to disease-modifying therapies targeting MS-specific mechanisms...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283110/access-delivery-and-perceived-efficacy-of-physiotherapy-and-use-of-complementary-and-alternative-therapies-by-people-with-progressive-multiple-sclerosis-in-the-united-kingdom-an-online-survey
#6
Evan Campbell, Elaine Coulter, Paul Mattison, Angus McFadyen, Linda Miller, Lorna Paul
INTRODUCTION: All people with progressive MS in the United Kingdom should have access to physiotherapy through the National Health Service (NHS). However levels of access and delivery are unknown. Furthermore there is no research on perceived efficacy of physiotherapy or the use of complementary and alternative medicine in people with progressive MS in the United Kingdom. METHODS: An online survey was carried out via the UK MS Register. Inclusion criteria were diagnosis of progressive MS, a member of UK MS Register and 18 years or older...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283109/classifying-pml-risk-with-disease-modifying-therapies
#7
REVIEW
Joseph R Berger
OBJECTIVE: To catalogue the risk of PML with the currently available disease modifying therapies (DMTs) for multiple sclerosis (MS). BACKGROUND: All DMTs perturb the immune system in some fashion. Natalizumab, a highly effective DMT, has been associated with a significant risk of PML. Fingolimod and dimethyl fumarate have also been unquestionably associated with a risk of PML in the MS population. Concerns about PML risk with other DMTs have arisen due to their mechanism of action and pharmacological parallel to other agents with known PML risk...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283108/higher-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-in-multiple-sclerosis-patients-is-related-to-spinal-cord-lesions
#8
M Minár, D Petrleničová, P Valkovič
BACKGROUND: Multiple sclerosis (MS) is connected with higher prevalence of secondary restless legs syndrome/Willis-Ekbom disease (RLS/WED). Aim of this study was to determine risk factor for developing symptoms of RLS in MS patients. METHODS: In cross-sectional study we examined 200 random MS patients. After obtaining informed consents, patients undervent a structured interview based on RLS and MS symptoms and characteristics, demographic, and health-related data...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283107/sexual-dysfunction-levels-in-iranian-women-suffering-from-multiple-sclerosis
#9
Nahid Dehghan-Nayeri, Zohreh Khakbazan, Faezeh Ghafoori, Seyed Massood Nabavi
OBJECTIVE: Sexual dysfunction (SD) is a common complaint in women who suffer from Multiple Sclerosis (MS), which has been categorized in three levels (primary, secondary, and tertiary) in previous studies. This study was conducted to assess the prevalence of sexual dysfunction (SD) at each level, and to identify associated factors and their impacts on SD in married women who suffer from Multiple Sclerosis. This study was conducted in Iran where the cultural barriers are recognized as important challenges in sexual function...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283106/vogt-koyanagi-harada-syndrome-mimicking-multiple-sclerosis-a-case-report-and-review-of-the-literature
#10
REVIEW
Hussein Algahtani, Bader Shirah, Raghad Algahtani, Abdulah Alkahtani, Saeed Alwadie
Vogt Koyanagi Harada (VKH) Syndrome, also called uveomeningioencephalitis, is a chronic disorder characterized by inflammation of the uvea, meninges, auditory system, and integumentary system. The association between VKH syndrome and multiple sclerosis (MS) has been reported only once in the literature in a patient who developed VKH syndrome after two years of the diagnosis of MS. In this article, we report a case who was misdiagnosed and treated as MS until she was proven to have VKH syndrome, and a diagnosis of MS was excluded...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283105/perinatal-characteristics-and-obstetric-complications-in-mothers-with-multiple-sclerosis-record-linkage-study
#11
Alexander Goldacre, Julia Pakpoor, Michael Goldacre
BACKGROUND: Multiple sclerosis (MS) predominantly onsets in women of reproductive age. The possibility of adverse obstetric and perinatal outcomes is a likely source of concern to pregnant women with MS and their clinicians. We aimed to compare the characteristics of the pregnancies of mothers with or without MS. METHODS: The historical Oxford Record Linkage Study specialised maternity dataset (850,000 people, 1970-1989), with record-linkage between mother and baby, was analysed...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283104/comparing-epidemiology-and-baseline-characteristic-of-multiple-sclerosis-and-neuromyelitis-optica-a-case-control-study
#12
COMPARATIVE STUDY
Sharareh Eskandarieh, Saharnaz Nedjat, Ibrahim Abdollahpour, Abdorreza Naser Moghadasi, Amir Reza Azimi, Mohammad Ali Sahraian
BACKGROUND: Autoimmune syndromes such as Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) are chronic, demyelinating diseases of the central nervous system which usually affect young adults. Both environmental risk factors and genetic susceptibility have been proposed to explain the etiology of these diseases. The aim of this study was to compare epidemiology and possible risk factors in MS and NMO in Tehran, Iran. METHOD: A population-based incident case-control study was performed in Tehran based on a study conducted on1513 MS patients from Iranian MS Society registry center of Tehran, from 2014 to 2015, and 83 NMO patients diagnosed with NMO in 2015 at Sina hospital, a tertiary care referral center in Tehran...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283103/there-is-less-mri-brain-lesions-and-no-characteristic-mri-brain-findings-in-iidds-patients-with-positive-aqp4-serology-among-malaysians
#13
Suhailah Abdullah, Farhana Fadzli, Norlisah Ramli, Chong Tin Tan
BACKGROUND AND OBJECTIVE: The recently introduced International Consensus diagnostic criteria for diagnosis of neuromyelitis spectrum disorder include patients who are seronegative for AQP4 antibody. The criteria are dependent on typical MRI changes in the spinal cord, optic nerve and brain. This study aims to determine whether there are significant differences in the MRI brain images between AQP4 positive and negative patients with IIDDs. METHOD: MRI brain of patients with a diagnosis of IIDDs presented to the Hospital from 2010 to 2015 was analysed...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283102/the-association-between-physical-activity-and-sleep-characteristics-in-people-with-multiple-sclerosis
#14
Aseel Aburub, Hanan Khalil, Alham Al-Sharman, Mahmoud Alomari, Omar Khabour
STUDY OBJECTIVES: The majority of individuals with multiple sclerosis (MS) suffer from sleep disorders. In this study, we investigated the relationship between physical activity and sleep characteristics in MS patients. METHODS: Sixty MS patients were recruited in the study. Sleep characteristics were assessed using the Actisleep device while physical activity levels were assessed using mobility accelerometer. RESULTS: The results showed that means (±SD) of sleep latency (SL) and sleep efficiency (ES) for MS patients were 23...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283101/sex-differences-in-outcomes-of-disease-modifying-treatments-for-multiple-sclerosis-a-systematic-review
#15
REVIEW
Rui Li, Xiaobo Sun, Yaqing Shu, Zhifeng Mao, Li Xiao, Wei Qiu, Zhengqi Lu, Xueqiang Hu
BACKGROUND: Multiple sclerosis (MS) is a chronic immune mediated demyelinating disease of the central nervous system that exhibits sexual dimorphism and may benefit from sex-specific treatment. To investigate a potential influence of sex on immunomodulatory therapeutic effects in patients with MS, we performed a comprehensive analysis of published studies examining sex differences in the effects of disease-modifying treatments (DMTs) for MS. METHODS: PubMed, Cochrane Library, and Web of Science databases were searched for clinical studies involving patients with MS who were undergoing DMTs...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283100/antecedent-anti-nmda-receptor-encephalitis-in-two-patients-with-multiple-sclerosis
#16
A Baheerathan, W J Brownlee, D T Chard, K Shields, R Gregory, S A Trip
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder characterised by psychiatric symptoms, movement disorder and seizures often evolving into a severe encephalopathy. An overlap has recently been recognised between anti-NMDAR encephalitis and inflammatory demyelinating disorders, particularly neuromyelitis optical spectrum disorder (NMOSD). In this case report, we describe two patients with an initial presentation consistent with anti-NMDAR encephalitis who have subsequently developed relapsing-remitting multiple sclerosis (MS) and discuss the literature pertaining to potential overlap between NMDAR encephalitis and inflammatory demyelinating disorders...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283099/sensitivity-of-visual-evoked-potentials-and-spectral-domain-optical-coherence-tomography-in-early-relapsing-remitting-multiple-sclerosis
#17
COMPARATIVE STUDY
Raed Behbehani, Samar Ahmed, Jasem Al-Hashel, Rossen T Rousseff, Raed Alroughani
BACKGROUND: Visual evoked potentials and spectral-domain optical coherence tomography are common ancillary studies that assess the visual pathways from a functional and structural aspect, respectively. OBJECTIVE: To compare prevalence of abnormalities of Visual evoked potentials (VEP) and spectral-domain optical coherence tomography (SDOCT) in patients with relapsing remitting multiple sclerosis (RRMS). METHODS: A cross-sectional study of 100 eyes with disease duration of less than 5 years since the diagnosis...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28283098/from-bugs-to-brains-the-microbiome-in-neurological-health
#18
EDITORIAL
Kyla A McKay, Kaarina Kowalec, Fiona Brinkman, B Brett Finlay, Marc Horwitz, Amee R Manges, Lisa Osborne, Helen Tremlett
Knowledge surrounding the trillions of microbes that inhabit the human gut has bloomed exponentially in recent years, and the emerging concept of a gut-brain axis represents a major shift in how we think about neurological health. A recent workshop at the University of British Columbia, Canada brought together multi-disciplinary leaders in the field of microbiomics and brain health and aimed to serve as a springboard for future combined endeavors in these areas. This article provides the motivation for, and overview of, the workshop, and the next steps in establishing a cross-disciplinary initiative on Brain Health and the Microbiome...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104262/editors-welcome
#19
EDITORIAL
Gavin Giovannoni, Chris Hawkes, Fred Lublin, Emmanuelle Waubant
No abstract text is available yet for this article.
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104261/multiple-sclerosis-association-of-gelatinase-b-matrix-metalloproteinase-9-with-risk-and-clinical-course-the-disease
#20
Ana Valado, Maria João Leitão, António Martinho, Rui Pascoal, João Cerqueira, Inês Correia, Sónia Batista, Lívia Sousa, Inês Baldeiras
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and axonal degeneration of the central nervous system and a leading cause of disability in young adults. The matrix metalloproteinases in general and specially gelatinase B/metalloproteinase-9 (MMP-9) plays a role in the pathogenesis of multiple sclerosis. OBJECTIVE: To investigate the presence of the MMP-9 -1562C/T polymorphism in a Portuguese population of MS patients and assess its impact in susceptibility and course of the disease...
January 2017: Multiple Sclerosis and related Disorders
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