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BioResearch Open Access

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https://www.readbyqxmd.com/read/29098120/effects-of-atrial-natriuretic-peptide-on-p53-and-estrogen-receptor-in-breast-cancer-cells
#1
Katie Aleck, Kelly Hallman, Meghan Quigley, Victoria Lloyd, Monica Szmyd, Dana Ruskin, Tyler Bedgood, Sumi Dinda
The atrial natriuretic peptide (ANP) hormone is secreted by cardiac atrial myocytes and acts to regulate blood pressure homeostasis in humans. Previous research indicates ANP treatment significantly decreases the proliferation of human prostate cancer cells, pancreatic adenocarcinoma, and breast cancer cells. Minimal studies have been conducted with regard to ANP regulating tumor suppressor genes and steroid hormone receptors in breast cancer cells. Our study analyzed the effects of ANP in combination with 17β-estradiol (E2) and antiestrogen treatments on p53 and ERα levels in T-47D breast cancer cells...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29098119/process-review-for-development-of-quantitative-risk-analyses-for-transboundary-animal-disease-to-pathogen-free-territories
#2
REVIEW
Jonathan Miller, Ken Burton, Joe Fund, Adrian Self
Outbreaks of transboundary animal diseases (TADs) have the potential to cause significant detriment to animal, human, and environmental health; severe economic implications; and national security. Challenges concerning data sharing, model development, decision support, and disease emergence science have recently been promoted. These challenges and recommendations have been recognized and advocated in the disciplines intersecting with outbreak prediction and forecast modeling regarding infectious diseases. To advance the effective application of computation and risk communication, analytical products ought to follow a collaboratively agreed common plan for implementation...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29098118/gut-microbiota-and-salivary-diagnostics-the-mouth-is-salivating-to-tell-us-something
#3
REVIEW
Krishna Kodukula, Douglas V Faller, David N Harpp, Iphigenia Kanara, Julie Pernokas, Mark Pernokas, Whitney R Powers, Nikolaos S Soukos, Kosta Steliou, Walter H Moos
The microbiome of the human body represents a symbiosis of microbial networks spanning multiple organ systems. Bacteria predominantly represent the diversity of human microbiota, but not to be forgotten are fungi, viruses, and protists. Mounting evidence points to the fact that the "microbial signature" is host-specific and relatively stable over time. As our understanding of the human microbiome and its relationship to the health of the host increases, it is becoming clear that many and perhaps most chronic conditions have a microbial involvement...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29098117/human-chorionic-gonadotropin-mediated-generation-of-reactive-oxygen-species-is-sufficient-to-induce-meiotic-exit-but-not-apoptosis-in-rat-oocytes
#4
Meenakshi Tiwari, Shail K Chaube
Generation of reactive oxygen species (ROS) is associated with final stages of follicular development and ovulation in mammals. The human chorionic gonadotropin (hCG) mimics the action of luteinizing hormone and triggers follicular development and ovulation. However, it remains unclear whether hCG induces generation of ROS, if yes, whether hCG-mediated increased level of ROS could induce meiotic exit and/or apoptosis in rat oocytes. For this purpose, cumulus-oocyte complexes (COCs) were collected from ovary of experimental rats injected with 20 IU pregnant mare's serum gonadotropin for 48 h followed by 20 IU hCG for 0, 7, 14, and 21 h...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29082109/supporting-the-one-carbon-cycle-restores-ovarian-reserve-in-subfertile-women-absence-of-correlation-with-urinary-bisphenol-a-concentration
#5
Erica Silvestris, Marc Cohen, Dominique Cornet, Laetitia Jacquesson-Fournols, Patrice Clement, Jacques Chouteau, Marc Schneider, Thierry Besnard, Yves Ménézo
Environmental endocrine disrupting chemicals (EDCs), including bisphenol A (BPA), induce DNA methylation errors and oxidative stress, and alter fertility. Animal studies have demonstrated that supporting the one-carbon cycle (1-CC) with appropriate dietary supplements can reduce the effects of EDCs. Anti-Mullerian hormone (AMH), a marker of ovarian functionality, has been tested in subfertile female patients, to control this hypothesis in humans. Fifty-five women with a history of 3-7 years of infertility, with at least two assisted reproductive technology (ART) treatment failures, and low serum levels of AMH were enrolled in the study...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29034133/local-cellular-responses-to-titanium-dioxide-from-orthopedic-implants
#6
REVIEW
Jie J Yao, Eric A Lewallen, William H Trousdale, Wei Xu, Roman Thaler, Christopher G Salib, Nicolas Reina, Matthew P Abdel, David G Lewallen, Andre J van Wijnen
We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO2) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO2 particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736691/prevalence-and-risk-factors-of-osteoporosis-among-jordanian-postmenopausal-women-attending-the-national-center-for-diabetes-endocrinology-and-genetics-in-jordan
#7
Dana Hyassat, Taghreed Alyan, Hashem Jaddou, Kamel M Ajlouni
To assess the prevalence of osteoporosis and osteopenia among Jordanian postmenopausal women attending the National Center for Diabetes, Endocrinology, and Genetics (NCDEG), and to determine the potential associated risk factors. A cross-sectional study was conducted at (NCDEG) in Amman, Jordan. A total of 1079 Jordanian postmenopausal women aged between 45 and 84 years were included in this study that was conducted during the period between April 2013 and December 2014. All patients underwent bone mineral density measurement through dual-energy X-ray absorptiometry (DEXA) scan...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736690/decellularization-of-human-internal-mammary-artery-biomechanical-properties-and-histopathological-evaluation
#8
Abdol-Mohammad Kajbafzadeh, Reza Khorramirouz, Seyede Maryam Kameli, Javad Hashemi, Amin Bagheri
This study undertook to create small-diameter vascular grafts and assess their structure and mechanical properties to withstand arterial implantation. Twenty samples of intact human internal mammary arteries (IMAs) were collected and decellularized using detergent-based methods. To evaluate residual cellular and extracellular matrix (ECM) components, histological analysis was performed. Moreover, collagen typing and ECM structure were analyzed by Picrosirius red and Movat's pentachrome staining. Scanning electron microscopy was also applied to assess microarchitecture of both endothelial and adventitial surfaces of native and decellularized arterial samples...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736689/induced-pluripotent-stem-cells-global-research-trends
#9
REVIEW
Takaharu Negoro, Hanayuki Okura, Akifumi Matsuyama
The induced pluripotent stem cell (iPSC) was first described more than 10 years ago and is currently used in various basic science and clinical research fields. The aim of this report is to examine the trends in research using iPSCs over the last 10 years. The 2006-2016 PubMed database was searched using the MeSH term "induced pluripotent stem cells." Only original research articles were selected, with a total of 3323 articles. These were classified according to research theme into reprogramming, differentiation protocols for specific cells and/or tissues, pathophysiological research on diseases, and discovery of new drugs, and then the trends over the years were analyzed...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736688/the-top-50-most-cited-articles-in-cartilage-regeneration
#10
REVIEW
Ciaran K Mc Donald, Peter Moriarty, Manvydas Varzgalis, Colin Murphy
The aim of this study was to identify and analyze the top 50 most cited articles in cartilage regeneration. The impact of a scientific journal can be gauged by the total number of citations it has accrued. The top 50 most cited articles involving cartilage regeneration represent the most quoted level of evidence among this new subspecialty. This study aims to identify and analyze the 50 most cited articles in cartilage regeneration. The Web of Science™ citation indexing service was utilized to determine the most frequently cited articles published after 1956 containing "cartilage regeneration" in the "topic" or "title...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736687/tissue-engineered-tendon-for-enthesis-regeneration-in-a-rat-rotator-cuff-model
#11
Michael J Smietana, Pablo Moncada-Larrotiz, Ellen M Arruda, Asheesh Bedi, Lisa M Larkin
Healing of rotator cuff (RC) injuries with current suture or augmented scaffold techniques fails to regenerate the enthesis and instead forms a weaker fibrovascular scar that is prone to subsequent failure. Regeneration of the enthesis is the key to improving clinical outcomes for RC injuries. We hypothesized that the utilization of our tissue-engineered tendon to repair either an acute or a chronic full-thickness supraspinatus tear would regenerate a functional enthesis and return the biomechanics of the tendon back to that found in native tissue...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28560090/correction-to-biores-open-access-2016-5-137-145
#12
(no author information available yet)
[This corrects the article DOI: 10.1089/biores.2016.0010.].
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28560089/characterization-of-a-murine-model-of-bioequivalent-bladder-wound-healing-and-repair-following-subtotal-cystectomy
#13
Mona Zarifpour, Karl-Erik Andersson, Sneha S Kelkar, Aaron Mohs, Cathy Mendelsohn, Kerry Schneider, Frank Marini, George J Christ
Previous work demonstrated restoration of a bioequivalent bladder within 8 weeks of removing the majority of the bladder (subtotal cystectomy or STC) in rats. The goal of the present study was to extend our investigations of bladder repair to the murine model, to harness the power of mouse genetics to delineate the cellular and molecular mechanisms responsible for the observed robust bladder regrowth. Female C57 black mice underwent STC, and at 4, 8, and 12 weeks post-STC, bladder repair and function were assessed via cystometry, ex vivo pharmacologic organ bath studies, and T2-weighted magnetic resonance imaging (MRI)...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28451472/cataract-surgery-and-visual-acuity-in-elderly-japanese-results-of-fujiwara-kyo-eye-study
#14
Kimie Miyata, Tadanobu Yoshikawa, Masashi Mine, Tomo Nishi, Nozomi Okamoto, Tetsuo Ueda, Ryo Kawasaki, Norio Kurumatani, Nahoko Ogata
The aim of this study was to determine the presence of prior cataract surgery and best-corrected visual acuity (BCVA) in an elderly Japanese cohort. The Fujiwara-kyo Eye Study was a prospective, population-based, cross-sectional epidemiological study. The subjects were ≥68 years who lived in the Nara Prefecture and responded to recruitment notices. All of the subjects underwent comprehensive ophthalmological examinations, and the sociodemographic information and medical history, including prior cataract surgery, were obtained by answers to a questionnaire...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28451471/can-handgrip-strength-improve-following-body-mass-based-lower-body-exercise
#15
Yu Yaginuma, Takashi Abe, Robert S Thiebaud, Takahiro Kitamura, Masashi Kawanishi, Tetsuo Fukunaga
Knee extension strength (KES) improves following body mass-based lower body exercise training; however, it is unknown whether this type of exercise increases handgrip strength (HGS) as a result of a cross-education effect in older individuals. Our aim was to investigate the effect of a body mass-based exercise intervention on HGS and KES in older adults. At baseline, 166 subjects started a 12-week intervention program, and 160 (108 women and 52 men) subjects completed the study. A self-selected group of 37 older adults (21 women and 16 men) served as a control group...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28303211/real-time-three-dimensional-echocardiography-characterization-of-cardiac-anatomy-and-function-current-clinical-applications-and-literature-review-update
#16
REVIEW
Omar Velasco, Morgan Q Beckett, Aaron W James, Megan N Loehr, Taylor G Lewis, Tahmin Hassan, Rajesh Janardhanan
Our review of real-time three-dimensional echocardiography (RT3DE) discusses the diagnostic utility of RT3DE and provides a comparison with two-dimensional echocardiography (2DE) in clinical cardiology. A Pubmed literature search on RT3DE was performed using the following key words: transthoracic, two-dimensional, three-dimensional, real-time, and left ventricular (LV) function. Articles included perspective clinical studies and meta-analyses in the English language, and focused on the role of RT3DE in human subjects...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28289555/gender-differences-in-post-traumatic-stress
#17
Maria Grazia Modena, Daniele Pettorelli, Giulia Lauria, Elisa Giubertoni, Erminio Mauro, Valentina Martinotti
Acute stress can trigger cardiovascular events and disease. The earthquake is an "ideal" natural experiment for acute and chronic stress, with impact mainly on the cardiovascular system. On May 20th and 29th, 2012, two earthquakes of magnitude 5.9° to 6.4° on the Richter scale, hit the province of Modena and Reggio Emilia, an area of the north-center of Italy never considered at seismic risk. The purpose of our study was to assess whether there were gender-specific differences in stress-induced incidence of cardiovascular events and age of patients who arrived at the Emergency Departments (ED) of the three main teaching hospitals of the University of Modena and Reggio Emilia...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28163982/biomimetics-of-bone-implants-the-regenerative-road
#18
REVIEW
Elizabeth Brett, John Flacco, Charles Blackshear, Michael T Longaker, Derrick C Wan
The current strategies for healing bone defects are numerous and varied. At the core of each bone healing therapy is a biomimetic mechanism, which works to enhance bone growth. These range from porous scaffolds, bone mineral usage, collagen, and glycosaminoglycan substitutes to transplanted cell populations. Bone defects face a range of difficulty in their healing, given the composite of dense outer compact bone and blood-rich inner trabecular bone. As such, the tissue possesses a number of inherent characteristics, which may be clinically harnessed as promoters of bone healing...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/27965915/mixed-fibronectin-derived-peptides-conjugated-to-a-chitosan-matrix-effectively-promotes-biological-activities-through-integrins-%C3%AE-4%C3%AE-1-%C3%AE-5%C3%AE-1-%C3%AE-v%C3%AE-3-and-syndecan
#19
Kentaro Hozumi, Kyotaro Nakamura, Haruna Hori, Mari Miyagi, Rika Nagao, Keiko Takasaki, Fumihiko Katagiri, Yamato Kikkawa, Motoyoshi Nomizu
Mimicking the biological function of the extracellular matrix is an approach to developing cell adhesive biomaterials. The RGD peptide, derived from fibronectin (Fn), mainly binds to integrin αvβ3 and has been widely used as a cell adhesive peptide on various biomaterials. However, cell adhesion to Fn is thought to be mediated by several integrin subtypes and syndecans. In this study, we synthesized an RGD-containing peptide (FIB1) and four integrin α4β1-binding-related motif-containing peptides (LDV, IDAPS, KLDAPT, and PRARI) and constructed peptide-chitosan matrices...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27965914/computational-model-based-analysis-of-strategies-to-enhance-scaffold-vascularization
#20
Elif Seyma Bayrak, Banu Akar, Sami I Somo, Chenlin Lu, Nan Xiao, Eric M Brey, Ali Cinar
Stable and extensive blood vessel networks are required for cell function and survival in engineered tissues. A number of different strategies are currently being investigated to enhance biomaterial vascularization with screening primarily through extensive in vitro and in vivo experiments. In this article, we describe an agent-based model (ABM) developed to evaluate various strategies in silico, including design of optimal biomaterial structure, delivery of angiogenic factors, and application of prevascularized biomaterials...
2016: BioResearch Open Access
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