journal
MENU ▼
Read by QxMD icon Read
search

Stem Cells Translational Medicine

journal
https://www.readbyqxmd.com/read/29777577/autologous-bone-marrow-mesenchymal-stem-cells-improve-the-quality-and-stability-of-vascularized-flap-surgery-of-irradiated-skin-in-pigs
#1
Christine Linard, Michel Brachet, Carine Strup-Perrot, Bruno L'homme, Elodie Busson, Claire Squiban, Valerie Holler, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey, Marc Benderitter
Cutaneous radiation syndrome has severe long-term health consequences. Because it causes an unpredictable course of inflammatory waves, conventional surgical treatment is ineffective and often leads to a fibronecrotic process. Data about the long-term stability of healed wounds, with neither inflammation nor resumption of fibrosis, are lacking. In this study, we investigated the effect of injections of local autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs), combined with plastic surgery for skin necrosis, in a large-animal model...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29777574/factors-influencing-the-umbilical-cord-blood-stem-cell-industry-an-evolving-treatment-landscape
#2
REVIEW
Carla Dessels, Marco Alessandrini, Michael Sean Pepper
Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is an attractive alternative to harvesting HSCs from bone marrow or when mobilized into peripheral blood. One of the most appealing attributes of UCB is that it can be banked for future use and hence provides an off-the-shelf solution for patients in urgent need of a transplantation...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29752869/allogeneic-umbilical-cord-blood-infusion-for-adults-with-ischemic-stroke-clinical-outcomes-from-a-phase-1-safety-study
#3
Daniel T Laskowitz, Ellen R Bennett, Rebecca J Durham, John J Volpi, Jonathan R Wiese, Michael Frankel, Elizabeth Shpall, Jeffry M Wilson, Jesse Troy, Joanne Kurtzberg
Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, relatively few patients are eligible for this therapy. We hypothesized that intravenous (IV) infusion of banked unrelated allogeneic umbilical cord blood (UCB) would improve functional outcomes in patients with ischemic stroke. To investigate this, we conducted a phase 1 open-label trial to assess the safety and feasibility of a single IV infusion of non-human leukocyte antigen (HLA) matched, ABO matched, unrelated allogeneic UCB into adult stroke patients...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29752867/topical-application-of-culture-expanded-cd34-umbilical-cord-blood-cells-from-frozen-units-accelerates-healing-of-diabetic-skin-wounds-in-mice
#4
Jennifer Whiteley, Theresa Chow, Hibret Adissu, Armand Keating, Ian M Rogers
Chronic and nonhealing wounds are constant health issues facing patients with type 2 diabetes. As the incidence of type 2 diabetes mellitus (T2DM) increases, the incidence of chronic wounds and amputations will rise. T2DM is associated with peripheral arterial occlusive disease, which leads to the development of nonhealing skin ulcers after minor trauma. Patients develop severe pain limiting their mobility and ability to work and take care of themselves thus putting a significant burden on the family and society...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29749717/using-mesenchymal-stromal-cells-in-islet-transplantation
#5
EDITORIAL
Ahmed A Arzouni, Andreia Vargas-Seymour, Nance Nardi, Aileen J F King, Peter M Jones
Islet transplantation has the potential to cure Type 1 diabetes but current clinical transplantation protocols are inefficient because of the extensive loss of functional islets during the immediate post-transplantation period. Studies in rodent models have demonstrated that co-transplanting mesencyhmal stromal cells (MSCs) with islets improves graft functional survival and transplantation outcomes, and some of the beneficial effects of MSCs are attributable to bioactive molecules secreted by MSCs. Clinical islet transplantation is almost exclusively via the hepatic portal vein, which does not facilitate co-engraftment of islets and MSCs so attention is currently focused on using cell-free cocktails of MSC-derived products to treat islets prior to transplantation...
May 11, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29745997/efficacy-of-human-placental-derived-stem-cells-in-collagen-vii-knockout-recessive-dystrophic-epidermolysis-bullosa-animal-model
#6
Yanling Liao, Larisa Ivanova, Rajarajeswari Sivalenka, Trevor Plumer, Hongwen Zhu, Xiaokui Zhang, Angela M Christiano, John A McGrath, Jodi P Gurney, Mitchell S Cairo
Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating inherited skin blistering disease caused by mutations in the COL7A1 gene that encodes type VII collagen (C7), a major structural component of anchoring fibrils at the dermal-epidermal junction (DEJ). We recently demonstrated that human cord blood-derived unrestricted somatic stem cells promote wound healing and ameliorate the blistering phenotype in a RDEB (col7a1-/- ) mouse model. Here, we demonstrate significant therapeutic effect of a further novel stem cell product in RDEB, that is, human placental-derived stem cells (HPDSCs), currently being used as human leukocyte antigen-independent donor cells with allogeneic umbilical cord blood stem cell transplantation in patients with malignant and nonmalignant diseases...
May 10, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29737632/mesenchymal-stem-cell-microvesicles-restore-protein-permeability-across-primary-cultures-of-injured-human-lung-microvascular-endothelial-cells
#7
Shuling Hu, Jeonghyun Park, Airan Liu, JaeHoon Lee, Xiwen Zhang, Qi Hao, Jae-Woo Lee
Our previous study demonstrated that mesenchymal stem cell (MSC) microvesicles (MV) reduced lung inflammation, protein permeability, and pulmonary edema in endotoxin-induced acute lung injury in mice. However, the underlying mechanisms for restoring lung protein permeability were not fully understood. In this current study, we hypothesized that MSC MV would restore protein permeability across injured human lung microvascular endothelial cells (HLMVEC) in part through the transfer of angiopoietin-1 (Ang1) mRNA to the injured endothelium...
May 8, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29730892/activation-of-p70s6-kinase-1-in-mesenchymal-stem-cells-is-essential-to-lung-tissue-repair
#8
Katsuyuki Takeda, Fangkun Ning, Joanne Domenico, Masakazu Okamoto, Shigeru Ashino, Sang-Ha Kim, Yi Yeong Jeong, Yoshiki Shiraishi, Naohiro Terada, Everett Rand Sutherland, Erwin W Gelfand
All-trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the reparative effects of the combination of the two and the role of p70S6 kinase-1 (p70S6k1) activation in the repair process have not been defined. Twenty-one days after intratracheal instillation of porcine pancreatic elastase (PPE), MSC and/or 10 days of ATRA treatment was initiated. Thirty-two days later, static lung compliance (Cst), mean linear intercepts (MLIs), and alveolar surface area (S) were measured...
May 5, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29709112/a-five-year-study-of-the-efficacy-of-purified-cd34-cell-therapy-for-angiitis-induced-no-option-critical-limb-ischemia
#9
Yuan Fang, Zheng Wei, Bin Chen, Tianyue Pan, Shiyang Gu, Peng Liu, Daqiao Guo, Xin Xu, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi, Yifan Liu, Zhihui Dong, Weiguo Fu
Angiitis-induced critical limb ischemia (AICLI) patients constitute a remarkable proportion of no-option critical limb ischemia (CLI) patients. Stem cell therapy has become an innovative and promising option for no-option CLI patients. As one of these promising stem cell therapies, purified CD34+ cell transplantation (PuCeT) has shown favorable short-term results. However, the long-term efficacy of PuCeT has yet to be reported. This study evaluates the long-term efficacy of PuCeT in AICLI patients. Twenty-seven AICLI patients were enrolled from May 2009 to December 2011...
April 30, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29701016/functional-integrity-and-gene-expression-profiles-of-human-cord-blood-derived-hematopoietic-stem-and-progenitor-cells-generated-in-vitro
#10
Roberto Dircio-Maldonado, Patricia Flores-Guzman, Julieta Corral-Navarro, Ileana Mondragón-García, Alfredo Hidalgo-Miranda, Fredy Omar Beltran-Anaya, Alberto Cedro-Tanda, Lourdes Arriaga-Pizano, Odette Balvanera-Ortiz, Hector Mayani
To date, different experimental strategies have been developed for the ex vivo expansion of human hematopoietic stem (HSCs) and progenitor (HPCs) cells. This has resulted in significant advances on the use of such expanded cells in transplantation settings. To this day, however, it is still unclear to what extent those stem and progenitor cells generated in vitro retain the functional and genomic integrity of their freshly isolated counterparts. In trying to contribute to the solving of this issue, in the present study we have selected and purified three different hematopoietic cell populations: HSCs (CD34+ CD38- CD45RA- CD71- Lin- cells), myeloid progenitor cells (CD34+ CD38+ CD45RA+ CD71- Lin- cells), and erythroid progenitor cells (CD34+ CD38+ CD45RA- CD71+ Lin- cells), obtained directly from fresh human umbilical cord blood (UCB) units or generated in vitro under particular culture conditions...
April 26, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29688622/cardiac-progenitor-cells-the-matrix-has-you
#11
Clotilde Castaldo, Isotta Chimenti
Components of the cardiac extracellular matrix (ECM) are synthesized by residing cells and are continuously remodeled by them. Conversely, residing cells (including primitive cells) receive constant biochemical and mechanical signals from the ECM that modulate their biology. The pathological progression of heart failure affects all residing cells, inevitably causing profound changes in ECM composition and architecture that, in turn, impact on cell phenotypes. Any regenerative medicine approach must aim at sustaining microenvironment conditions that favor cardiogenic commitment of therapeutic cells and minimize pro-fibrotic signals, while conversely boosting the capacity of therapeutic cells to counteract adverse remodeling of the ECM...
April 24, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29665255/concise-review-rational-use-of-mesenchymal-stem-cells-in-the-treatment-of-ischemic-heart-disease
#12
REVIEW
Michael R Ward, Armin Abadeh, Kim A Connelly
The capacity of stem and progenitor cells to stimulate cardiac regeneration has been studied for almost 20 years, with very promising preclinical data and mixed clinical results. Several cell types have been studied, identified by their cell surface markers, differentiation capacity and their secreted growth factors. Bone marrow derived mesenchymal stem cells (MSCs) have been found to have potent regenerative capacity, through multiple mechanisms, including mesoderm lineage differentiation, immunomodulation, and paracrine stimulation...
April 17, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29656536/mmr-deficiency-does-not-sensitize-or-compromise-the-function-of-hematopoietic-stem-cells-to-low-and-high-let-radiation
#13
Rutulkumar Patel, Yulan Qing, Lucy Kennedy, Yan Yan, John Pink, Brittany Aguila, Amar Desai, Stanton L Gerson, Scott M Welford
One of the major health concerns on long-duration space missions will be radiation exposure to the astronauts. Outside the earth's magnetosphere, astronauts will be exposed to galactic cosmic rays (GCR) and solar particle events that are principally composed of protons and He, Ca, O, Ne, Si, Ca, and Fe nuclei. Protons are by far the most common species, but the higher atomic number particles are thought to be more damaging to biological systems. Evaluation and amelioration of risks from GCR exposure will be important for deep space travel...
April 14, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29589874/genome-editing-in-neuroepithelial-stem-cells-to-generate-human-neurons-with-high-adenosine-releasing-capacity
#14
Daniel Poppe, Jonas Doerr, Marion Schneider, Ruven Wilkens, Julius A Steinbeck, Julia Ladewig, Allison Tam, David E Paschon, Philip D Gregory, Andreas Reik, Christa E Müller, Philipp Koch, Oliver Brüstle
As a powerful regulator of cellular homeostasis and metabolism, adenosine is involved in diverse neurological processes including pain, cognition, and memory. Altered adenosine homeostasis has also been associated with several diseases such as depression, schizophrenia, or epilepsy. Based on its protective properties, adenosine has been considered as a potential therapeutic agent for various brain disorders. Since systemic application of adenosine is hampered by serious side effects such as vasodilatation and cardiac suppression, recent studies aim at improving local delivery by depots, pumps, or cell-based applications...
March 28, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29667344/concise-review-aggressive-colorectal-cancer-role-of-epithelial-cell-adhesion-molecule-in-cancer-stem-cells-and-epithelial-to-mesenchymal-transition
#15
REVIEW
Maximilian Boesch, Gilbert Spizzo, Andreas Seeber
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In spite of various attempts to ameliorate outcome by escalating treatment, significant improvement is lacking particularly in the adjuvant setting. It has been proposed that cancer stem cells (CSCs) and the epithelial-to-mesenchymal transition (EMT) are at least partially responsible for therapy resistance in CRC. The epithelial cell adhesion molecule (EpCAM) was one of the first CSC antigens to be described. Furthermore, an EpCAM-specific antibody (edrecolomab) has the merit of having launched the era of monoclonal antibody treatment in oncology in the 1990s...
June 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29654654/compressed-collagen-enhances-stem-cell-therapy-for-corneal-scarring
#16
Golnar Shojaati, Irona Khandaker, Kyle Sylakowski, Martha L Funderburgh, Yiqin Du, James L Funderburgh
Stem cells from human corneal stroma (CSSC) suppress corneal stromal scarring in a mouse wound-healing model and promote regeneration of native transparent tissue (PMID:25504883). This study investigated efficacy of compressed collagen gel (CCG) as a vehicle to deliver CSSC for corneal therapy. CSSC isolated from limbal stroma of human donor corneas were embedded in soluble rat-tendon collagen, gelled at 37°C, and partially dehydrated to a thickness of 100 µm by passive absorption. The CCG disks were dimensionally stable, easy to handle, and could be adhered securely to de-epithelialized mouse cornea with fibrin-based adhesive...
June 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29635868/mesenchymal-stem-cells-msc-derived-from-induced-pluripotent-stem-cells-ipsc-equivalent-to-adipose-derived-msc-in-promoting-intestinal-healing-and-microbiome-normalization-in-mouse-inflammatory-bowel-disease-model
#17
Sirikul Soontararak, Lyndah Chow, Valerie Johnson, Jonathan Coy, William Wheat, Daniel Regan, Steven Dow
Cellular therapy with allogeneic or autologous mesenchymal stem cells (MSC) has emerged as a promising new therapeutic strategy for managing inflammatory bowel disease (IBD). However, MSC therapy ideally requires a convenient and relatively homogenous cell source (typically bone marrow or adipose tissues) and the ability to generate cells with stable phenotype and function. An alternative means of generating allogeneic MSC is to derive them from induced pluripotent stem cells (iPSC), which could in theory provide an indefinite supply of MSC with well-defined phenotype and function...
June 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29604192/a-preview-of-selected-articles
#18
Stuart P Atkinson
No abstract text is available yet for this article.
May 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29573563/quality-quantity-control-culture-enhances-vasculogenesis-and-wound-healing-efficacy-of-human-diabetic-peripheral-blood-cd34-cells
#19
Rica Tanaka, Haruchika Masuda, Satoshi Fujimura, Rie Ito-Hirano, Kayo Arita, Yusuke Kakinuma, Hiroko Hagiwara, Makiko Kado, Ayato Hayashi, Tomoya Mita, Takasuke Ogawa, Hirotaka Watada, Hiroshi Mizuno, Naoki Sawada, Takayuki Asahara
Autologous endothelial progenitor cell (EPC) therapy is commonly used to stimulate angiogenesis in ischemic repair and wound healing. However, low total numbers and functional deficits of EPCs make autologous EPC therapy ineffective in diabetes. Currently, no known ex vivo culture techniques can expand and/or ameliorate the functional deficits of EPCs for clinical usage. Recently, we showed that a quality-quantity culture (QQc) system restores the vasculogenic and wound-healing efficacy of murine diabetic EPCs...
May 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29573225/concise-review-stem-cell-fate-guided-by-bioactive-molecules-for-tendon-regeneration
#20
REVIEW
Yan-Jie Zhang, Xiao Chen, Gang Li, Kai-Ming Chan, Boon Chin Heng, Zi Yin, Hong-Wei Ouyang
Tendon disorders, which are commonly presented in the clinical setting, disrupt the patients' normal work and life routines, and they damage the careers of athletes. However, there is still no effective treatment for tendon disorders. In the field of tissue engineering, the potential of the therapeutic application of exogenous stem cells to treat tendon pathology has been demonstrated to be promising. With the development of stem cell biology and chemical biology, strategies that use inductive tenogenic factors to program stem cell fate in situ are the most easily and readily translatable to clinical applications...
May 2018: Stem Cells Translational Medicine
journal
journal
43940
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"