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Stem Cells Translational Medicine

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https://www.readbyqxmd.com/read/28429849/public-support-in-the-u-s-for-human-animal-chimera-research-results-of-a-representative-cross-sectional-survey-of-1-058-adults
#1
LETTER
Jonathan Kantor
No abstract text is available yet for this article.
April 21, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28425576/bone-marrow-adipose-and-lung-tissue-derived-murine-mesenchymal-stromal-cells-release-different-mediators-and-differentially-affect-airway-and-lung-parenchyma-in-experimental-asthma
#2
Soraia C Abreu, Mariana A Antunes, Debora G Xisto, Fernanda F Cruz, Vivian C Branco, Elga Bandeira, Jamil Zola Kitoko, Almair F de Araújo, Ludmilla Dellatorre-Texeira, Priscilla C Olsen, Daniel J Weiss, Bruno L Diaz, Marcelo M Morales, Patricia R M Rocco
Mesenchymal stromal cells (MSCs) from different sources have differential effects on lung injury. To compare the effects of murine MSCs from bone marrow (BM), adipose tissue (AD), and lung tissue (LUNG) on inflammatory and remodeling processes in experimental allergic asthma, female C57BL/6 mice were sensitized and challenged with ovalbumin (OVA) or saline (C). Twenty-four hours after the last challenge, mice received either saline (50 µl, SAL), BM-MSCs, AD-MSCs, or LUNG-MSCs (10(5) cells per mouse in 50 µl total volume) intratracheally...
April 20, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28378499/autologous-cord-blood-infusions-are-safe-and-feasible-in-young-children-with-autism-spectrum-disorder-results-of-a-single-center-phase-i-open-label-trial
#3
Geraldine Dawson, Jessica M Sun, Katherine S Davlantis, Michael Murias, Lauren Franz, Jesse Troy, Ryan Simmons, Maura Sabatos-DeVito, Rebecca Durham, Joanne Kurtzberg
Despite advances in early diagnosis and behavioral therapies, more effective treatments for children with autism spectrum disorder (ASD) are needed. We hypothesized that umbilical cord blood-derived cell therapies may have potential in alleviating ASD symptoms by modulating inflammatory processes in the brain. Accordingly, we conducted a phase I, open-label trial to assess the safety and feasibility of a single intravenous infusion of autologous umbilical cord blood, as well as sensitivity to change in several ASD assessment tools, to determine suitable endpoints for future trials...
April 5, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28375556/human-kidney-derived-cells-ameliorate-acute-kidney-injury-without-engrafting-into-renal-tissue
#4
Ilaria Santeramo, Zeneida Herrera Perez, Ana Illera, Arthur Taylor, Simon Kenny, Patricia Murray, Bettina Wilm, Norbert Gretz
Previous studies have suggested that CD133(+) cells isolated from human kidney biopsies have the potential to ameliorate injury following intravenous (IV) administration in rodent models of kidney disease by integrating into damaged renal tissue and generating specialized renal cells. However, whether renal engraftment of CD133(+) cells is a prerequisite for ameliorating injury has not yet been unequivocally resolved. Here, we have established a cisplatin-induced nephropathy model in immunodeficient rats to assess the efficacy of CD133(+) human kidney cells in restoring renal health, and to determine the fate of these cells after systemic administration...
April 4, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28371411/generation-of-integration-free-induced-pluripotent-stem-cells-from-urine-derived-cells-isolated-from-individuals-with-down-syndrome
#5
Young M Lee, Bruna L Zampieri, Jonah J Scott-McKean, Mark W Johnson, Alberto C S Costa
Down syndrome (DS) is a genetic disorder caused by trisomy 21 (T21). Over the past two decades, the use of mouse models has led to significant advances in the understanding of mechanisms underlying various phenotypic features and comorbidities secondary to T21 and even informed the design of clinical trials aimed at enhancing the cognitive abilities of persons with DS. In spite of its success, this approach has been plagued by all the typical limitations of rodent modeling of human disorders and diseases. Recently, several laboratories have succeeded in producing T21 human induced pluripotent stem cells (T21-iPSCs) from individuals with DS, which is emerging as a promising complementary tool for the study of DS...
March 28, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28337852/turning-potential-into-action-using-pluripotent-stem-cells-to-understand-heart-development-and-function-in-health-and-disease
#6
Hananeh Fonoudi, Alexis Bosman
Pluripotent stem cells hold enormous potential for regenerative therapies, however their ability to provide insight into early human development and the origins of disease could arguably provide an even greater outcome. This is primarily due to their contribution to the establishment of a powerful knowledge base of human development, something which all researchers and clinicians can potentially benefit from. Modeling human heart development and disease using pluripotent stem cells has already provided many important insights into cardiogenesis and cardiovascular disease mechanisms however, it is important to be aware of the complexities of this model system...
March 24, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28296268/feasibility-and-efficacy-of-intra-arterial-administration-of-mesenchymal-stem-cells-in-an-animal-model-of-double-toxin-induced-multiple-system-atrophy
#7
Ha Na Kim, Dong Yeol Kim, Se Hee Oh, Hyung Sook Kim, Kyung Suk Kim, Phil Hyu Lee
Multiple system atrophy (MSA) is a sporadic neurodegenerative disease of the central and autonomic nervous system. Because no drug treatment consistently benefits MSA patients, neuroprotective strategy using mesenchymal stem cells (MSCs) has a lot of concern for the management of MSA. In this study, we investigated the safety and efficacy of intra-arterial administration of MSCs via internal carotid artery (ICA) in an animal model of MSA. The study was composed of feasibility test using a ×10 and ×50 of a standard dose of MSCs (4 × 10(7) MSCs) and efficacy test using a ×0...
March 13, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28296283/effects-of-transendocardial-cd34-cell-transplantation-on-diastolic-parameters-in-patients-with-nonischemic-dilated-cardiomyopathy
#8
Mojca Bervar, Mirta Kozelj, Gregor Poglajen, Matjaz Sever, Gregor Zemljic, Sabina Frljak, Marko Cukjati, Peter Cernelc, François Haddad, Bojan Vrtovec
We sought to evaluate the physiological background and the effects of CD34(+) cell transplantation on diastolic parameters in nonischemic dilated cardiomyopathy patients (DCM). We enrolled 38 DCM patients with NYHA class III and LVEF <40% who underwent transendocardial CD34(+) cell transplantation. Peripheral blood CD34(+) cells were mobilized by G-CSF, collected via apheresis, and injected transendocardially in the areas of myocardial hibernation. Patients were followed for 1 year. At baseline, estimated filling pressures were significantly elevated (E/e'≥15) in 18 patients (Group A), and moderately elevated (E/e'<15) in 20 patients (Group B)...
March 11, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28296182/endothelial-progenitors-a-consensus-statement-on-nomenclature
#9
EDITORIAL
Reinhold J Medina, Chad L Barber, Florence Sabatier, Francoise Dignat-George, Juan M Melero-Martin, Kiarash Khosrotehrani, Osamu Ohneda, Anna M Randi, Jerry K Y Chan, Teruhide Yamaguchi, Victor W M Van Hinsbergh, Mervin C Yoder, Alan W Stitt
Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct cell subtypes continually grouped under the term "EPC." It would be highly advantageous to agree standards to confirm an endothelial progenitor phenotype and this should include detailed immunophenotyping, potency assays, and clear separation from hematopoietic angiogenic cells which are not endothelial progenitors. In this review, we seek to discourage the indiscriminate use of "EPCs," and instead propose precise terminology based on defining cellular phenotype and function...
March 10, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28276172/ascorbic-acid-promotes-the-stemness-of-corneal-epithelial-stem-progenitor-cells-and-accelerates-epithelial-wound-healing-in-the-cornea
#10
Jialin Chen, Jie Lan, Dongle Liu, Ludvig J Backman, Wei Zhang, Qingjun Zhou, Patrik Danielson
High concentration of ascorbic acid (vitamin C) has been found in corneal epithelium of various species. However, the specific functions and mechanisms of ascorbic acid in the repair of corneal epithelium are not clear. In this study, it was found that ascorbic acid accelerates corneal epithelial wound healing in vivo in mouse. In addition, ascorbic acid enhanced the stemness of cultured mouse corneal epithelial stem/progenitor cells (TKE2) in vitro, as shown by elevated clone formation ability and increased expression of stemness markers (especially p63 and SOX2)...
March 9, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28271621/first-characterization-of-human-amniotic-fluid-stem-cell-extracellular-vesicles-as-a-powerful-paracrine-tool-endowed-with-regenerative-potential
#11
Carolina Balbi, Martina Piccoli, Lucio Barile, Andrea Papait, Andrea Armirotti, Elisa Principi, Daniele Reverberi, Luisa Pascucci, Pamela Becherini, Luigi Varesio, Massimo Mogni, Domenico Coviello, Tiziano Bandiera, Michela Pozzobon, Ranieri Cancedda, Sveva Bollini
Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and significant regenerative potential in several preclinical models of disease. Nevertheless, little is known about the detailed characterization of their secretome. Herein we show for the first time that hAFS actively release extracellular vesicles (EV) endowed with significant paracrine potential and regenerative effect. c-KIT(+) hAFS were isolated from leftover samples of amniotic fluid from prenatal screening and stimulated to enhance EV release (24 hours 20% O2 versus 1% O2 preconditioning)...
March 8, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28252842/effects-of-transendocardial-stem-cell-injection-on-ventricular-proarrhythmia-in-patients-with-ischemic-cardiomyopathy-results-from-the-poseidon-and-tac-hft-trials
#12
Archana Ramireddy, Chad R Brodt, Adam M Mendizabal, Darcy L DiFede, Chris Healy, Vishal Goyal, Yahya Alansari, James O Coffey, Juan F Viles-Gonzalez, Alan W Heldman, Jeffrey J Goldberger, Robert J Myerburg, Joshua M Hare, Raul D Mitrani
Transendocardial stem cell injection in patients with ischemic cardiomyopathy (ICM) improves left ventricular function and structure but has ill-defined effects on ventricular arrhythmias. We hypothesized that mesenchymal stem cell (MSC) implantation is not proarrhythmic. Post hoc analyses were performed on ambulatory ECGs collected from the POSEIDON and TAC-HFT trials. Eighty-eight subjects (mean age 61 ± 10 years) with ICM (mean EF 32.2% ± 9.8%) received treatment with MSC (n = 48), Placebo (n = 21), or bone marrow mononuclear cells (BMC) (n = 19)...
March 2, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28244269/selective-expansion-of-skeletal-muscle-stem-cells-from-bulk-muscle-cells-in-soft-three-dimensional-fibrin-gel
#13
Pei Zhu, Yalu Zhou, Furen Wu, Yuanfan Hong, Xin Wang, Gajendra Shekhawat, Jeffrey Mosenson, Wen-Shu Wu
Muscle stem cells (MuSCs) exhibit robust myogenic potential in vivo, thus providing a promising curative treatment for muscle disorders. Ex vivo expansion of adult MuSCs is highly desired to achieve a therapeutic cell dose because of their scarcity in limited muscle biopsies. Sorting of pure MuSCs is generally required for all the current culture systems. Here we developed a soft three-dimensional (3D) salmon fibrin gel culture system that can selectively expand mouse MuSCs from bulk skeletal muscle preparations without cell sorting and faithfully maintain their regenerative capacity in culture...
February 28, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28244243/angiotensin-ii-causes-apoptosis-of-adult-hippocampal-neural-stem-cells-and-memory-impairment-through-the-action-on-ampk-pgc1%C3%AE-signaling-in-heart-failure
#14
Min-Seok Kim, Geun-Hee Lee, Yong-Min Kim, Byoung-Wook Lee, Hae Yun Nam, U-Cheol Sim, Suk-Jung Choo, Seong-Woon Yu, Jae-Joong Kim, Yunhee Kim Kwon, Seong Who Kim
Data are limited on the mechanisms underlying memory impairment in heart failure (HF). We hypothesized that angiotensin II (Ang II) may determine the fate of adult hippocampal neural stem cells (HCNs), a cause of memory impairment in HF. HCNs with neurogenesis potential were isolated and cultured from adult rat hippocampi. Ang II decreased HCN proliferation in dose- and time-dependent manners. Moreover, Ang II treatment (1 µM) for 48 hours induced apoptotic death, which was attenuated by pretreatment with Ang II receptor blockers (ARBs)...
February 28, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28244236/concise-reviews-innate-and-adaptive-immune-recognition-of-allogeneic-and-xenogeneic-cell-transplants-in-the-central-nervous-system
#15
Chloé J Hoornaert, Debbie Le Blon, Alessandra Quarta, Jasmijn Daans, Herman Goossens, Zwi Berneman, Peter Ponsaerts
Over the last 30 years, numerous allogeneic and xenogeneic cell grafts have been transplanted into the central nervous system (CNS) of mice and men in an attempt to cure neurological diseases. In the early studies, human or porcine embryonic neural cells were grafted in the striatum of animals or patients in an attempt to replace lost neurons. Although the immune-privileged status of the brain as a recipient organ was widely accepted, it rapidly became evident that CNS-grafted allogeneic and xenogeneic cells could be recognized and rejected by the immune system, resulting in poor neural graft survival and limited functional recovery...
February 28, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28225193/human-neural-progenitor-transplantation-rescues-behavior-and-reduces-%C3%AE-synuclein-in-a-transgenic-model-of-dementia-with-lewy-bodies
#16
Natalie R S Goldberg, Samuel E Marsh, Joseph Ochaba, Brandon C Shelley, Hayk Davtyan, Leslie M Thompson, Joan S Steffan, Clive N Svendsen, Mathew Blurton-Jones
Synucleinopathies are a group of neurodegenerative disorders sharing the common feature of misfolding and accumulation of the presynaptic protein α-synuclein (α-syn) into insoluble aggregates. Within this diverse group, Dementia with Lewy Bodies (DLB) is characterized by the aberrant accumulation of α-syn in cortical, hippocampal, and brainstem neurons, resulting in multiple cellular stressors that particularly impair dopamine and glutamate neurotransmission and related motor and cognitive function. Recent studies show that murine neural stem cell (NSC) transplantation can improve cognitive or motor function in transgenic models of Alzheimer's and Huntington's disease, and DLB...
February 22, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28213979/mmp-2-and-mmp-14-silencing-inhibits-vegfr2-cleavage-and-induces-the-differentiation-of-porcine-adipose-derived-mesenchymal-stem-cells-to-endothelial-cells
#17
Sami G Almalki, Yovani Llamas Valle, Devendra K Agrawal
The molecular mechanisms that control the ability of adipose-derived mesenchymal stem cells (AMSCs) to remodel three-dimensional extracellular matrix barriers during differentiation are not clearly understood. Herein, we studied the expression of matrix metalloproteinases (MMPs) during the differentiation of AMSCs to endothelial cells (ECs) in vitro. MSCs were isolated from porcine abdominal adipose tissue, and characterized by immunopositivity to CD44, CD90, CD105, and immunonegativity to CD14 and CD45. Plasticity of AMSCs was confirmed by multilineage differentiation...
February 18, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28205406/potency-of-human-cardiosphere-derived-cells-from-patients-with-ischemic-heart-disease-is-associated-with-robust-vascular-supportive-ability
#18
Emma Harvey, Huajun Zhang, Pilar Sepúlveda, Sara P Garcia, Dominic Sweeney, Fizzah A Choudry, Delia Castellano, George N Thomas, Hassan Kattach, Romina Petersen, Derek J Blake, David P Taggart, Mattia Frontini, Suzanne M Watt, Enca Martin-Rendon
Cardiosphere-derived cell (CDC) infusion into damaged myocardium has shown some reparative effect; this could be improved by better selection of patients and cell subtype. CDCs isolated from patients with ischemic heart disease are able to support vessel formation in vitro but this ability varies between patients. The primary aim of our study was to investigate whether the vascular supportive function of CDCs impacts on their therapeutic potential, with the goal of improving patient stratification. A subgroup of patients produced CDCs which did not efficiently support vessel formation (poor supporter CDCs), had reduced levels of proliferation and increased senescence, despite them being isolated in the same manner and having a similar immunophenotype to CDCs able to support vessel formation...
February 16, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28198124/long-distance-axonal-growth-and-protracted-functional-maturation-of-neurons-derived-from-human-induced-pluripotent-stem-cells-after-intracerebral-transplantation
#19
Jonathan C Niclis, Christopher Turner, Jennifer Durnall, Stuart McDougal, Jessica A Kauhausen, Bryan Leaw, Mirella Dottori, Clare L Parish, Lachlan H Thompson
The capacity for induced pluripotent stem (iPS) cells to be differentiated into a wide range of neural cell types makes them an attractive donor source for autologous neural transplantation therapies aimed at brain repair. Translation to the in vivo setting has been difficult, however, with mixed results in a wide variety of preclinical models of brain injury and limited information on the basic in vivo properties of neural grafts generated from human iPS cells. Here we have generated a human iPS cell line constitutively expressing green fluorescent protein as a basis to identify and characterize grafts resulting from transplantation of neural progenitors into the adult rat brain...
February 15, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28371563/placental-stromal-cell-therapy-for-experimental-autoimmune-encephalomyelitis-the-role-of-route-of-cell-delivery
#20
Ilona Shapira, Nina Fainstein, Maria Tsirlin, Ilana Stav, Evgenia Volinsky, Claudia Moresi, Tamir Ben-Hur, Raphael Gorodetsky
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) with no effective treatment available for the chronic-progressive stage. Cell therapy is a promising therapeutic approach for attenuating the immune-mediated CNS process. Isolated and expanded human placental stromal cells (hPSCs) possess potent immunomodulatory and trophic properties, making them a good candidate for MS therapy. We examined the potential of hPSC therapy in preventing the onset or attenuating the course of established disease in a murine MS model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis...
April 2017: Stem Cells Translational Medicine
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