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Natural Products and Bioprospecting

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https://www.readbyqxmd.com/read/29980943/research-of-panax-spp-in-kunming-institute-of-botany-cas
#1
REVIEW
Yi-Jun Qiao, Jia-Huan Shang, Dong Wang, Hong-Tao Zhu, Chong-Ren Yang, Ying-Jun Zhang
Panax, a genus of the Araliaceae family, is an important herbal group in traditional Chinese medicine (TCM). Nine species and three varieties are included in the genus of Panax, in which nearly all species have been used for medicinal purposes. Among them, Panax notoginseng (Burk) F. H. Chen, Panax ginseng C. A. Meyer and Panax quinquefolius L. are the most representative and valuable herbs world-wide, with a long history of cultivation. As the main bioactive chemical constituents, saponins with different aglycones are the major components in various Panax spp...
July 6, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29978386/the-progress-of-anti-hbv-constituents-from-medicinal-plants-in-china
#2
REVIEW
Chang-An Geng, Ji-Jun Chen
Hepatitis B virus (HBV) infection causing acute and chronic hepatitis is a serious problem worldwide, whereas the current treatment methods are unsatisfactory. Traditional Chinese herbs that have long been used for medicinal purposes are fascinating sources for novel anti-HBV candidates. This paper summarizes the progress of anti-HBV constituents from diverse medicinal plants in China to provide information for searching new anti-HBV drugs from natural sources.
July 5, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29974338/small-molecule-targets-in-tumor-immunotherapy
#3
REVIEW
Hui-Fang Zhu, Yan Li
Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success of targeting the T cell immune checkpoint receptors PD-1 or CTLA4 by antibodies blockade in advanced stages of cancers has demonstrated the importance of immune modulation. But antibodies-based immunotherapy confronted with some disadvantages, such as immunogenicity, stability, membrane permeability, and production cost...
July 5, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29974350/untiring-researches-for-alternative-resources-of-rhizoma-paridis
#4
REVIEW
Xu-Jie Qin, Wei Ni, Chang-Xiang Chen, Hai-Yang Liu
Rhizoma Paridis (RP, ), a traditional Chinese medicine, is the rhizoma of Paris polyphylla var. yunnanensis (PPY) or P. polyphylla var. chinensis which are widely used as important raw materials for several Chinese patent drugs. However, the wild resources of these herbs have become less and less due to their slow-growing characteristics and previously excessive excavation. This review covers untiring investigations on alternative resources of RP by our research group over the past decades, including non-medicinal parts of PPY as well as other plants of Liliaceae and Liliflorae families...
July 4, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29959744/application-of-metabolomics-in-the-study-of-natural-products
#5
Qi Zhao, Jia-Le Zhang, Fei Li
LC-MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro and in vivo metabolism of natural compounds, such as osthole, dehydrodiisoeugenol, and myrislignan. The pharmacological effects of natural compounds and extracts were determined using metabolomics technology combined with diseases models in animal, including osthole and nutmeg extracts...
June 29, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29943349/residual-dipolar-couplings-in-structure-determination-of-natural-products
#6
REVIEW
Gao-Wei Li, Han Liu, Feng Qiu, Xiao-Juan Wang, Xin-Xiang Lei
The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will provide a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized...
June 25, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29934731/medicinal-plant-using-ground-state-stabilization-of-natural-antioxidant-curcumin-by-keto-enol-tautomerisation
#7
S Manimaran, K SambathKumar, R Gayathri, K Raja, N Rajkamal, M Venkatachalapathy, G Ravichandran, C Lourdu EdisonRaj
Curcumin is a medicinal agent that exhibits anti-cancer properties and bioactive pigment in Turmeric has a huge therapeutic value. It has a keto-enol moiety that gives rise to many of its chemical properties. A recent study has shown that keto-enol tautomerisation at this moiety is implicated the effect of curcumin. The tautomerisation of curcumin in methanol, acetone and acetonitrile are used in nuclear magnetic resonance (1 H, 13 C) spectroscopy. It was characterized using UV, IR and Raman spectral values...
June 22, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29915912/two-new-alkaloids-from-fusarium-tricinctum-sypf-7082-an-endophyte-from-the-root-of-panax-notoginseng
#8
Wen-Jie Sun, Hong-Tao Zhu, Tian-Yuan Zhang, Meng-Yue Zhang, Dong Wang, Chong-Ren Yang, Yi-Xuan Zhang, Ying-Jun Zhang
Panax notoginseng (Araliaceae) is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of China. Two new alkaloids, rigidiusculamide E (1) and [-(α-oxyisohexanoyl-N-methyl-leucyl)2 -] (2), together with two known ones, (-)-oxysporidinone (3) and (-)-4,6'-anhydrooxysporidinone (4) were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082, an endophytic fungus obtained from the healthy root of P. notoginseng. Their structures were determined on the basis of extensive spectroscopic analyses...
June 18, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29909523/synthesis-and-cytotoxicities-of-royleanone-derivatives
#9
Cheng-Ji Li, Fan Xia, Rong Wu, Hong-Sheng Tan, Hong-Xi Xu, Gang Xu, Hong-Bo Qin
Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.
June 16, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29876754/assessment-of-expression-cassettes-and-culture-media-for-different-escherichia-coli-strains-to-produce-astaxanthin
#10
Shun Li, Jun-Chao Huang
Astaxanthin is a value-added ketocarotenoid with great potential in nutraceutical and pharmaceutical industries. Genetic engineering of heterologous hosts for astaxanthin production has attracted great attention. In this study, we assessed some key factors, including codon usage of the expressed genes, types of promoters, bacterial strains, and culture media, for engineered Escherichia coli to produce astaxanthin. The effect of codon usage was shown to be related to the types of promoters. E. coli DH5α was superior to other strains for astaxanthin production...
June 6, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29855857/-%C3%A2-zanthonitidine-a-a-pair-of-enantiomeric-furoquinoline-alkaloids-from-zanthoxylum-nitidum-with-antibacterial-activity
#11
Li-Na Zhao, Xi-Xi Guo, Shuai Liu, Li Feng, Qi-Rui Bi, Zhe Wang, Ning-Hua Tan
A pair of new enantiomeric furoquinoline alkaloids, (±)-zanthonitidine A (1), together with nine known ones (2-10) were isolated from the radix of Zanthoxylum nitidum. Their chemical structures were elucidated based on the extensive spectroscopic analysis. The racemic mixture of 1 was separated by chiral column chromatography, and the absolute configurations of (+)-1 and (-)-1 were determined by the comparison of experimental and calculated electronic circular dichroism spectra. Antibacterial activities of compounds 1-9 were evaluated, and compounds (+)-1, (-)-1, 3, 7 and 8 showed antibacterial activities against Bacillus subtilis, Enterococcus faecalis or Staphylococcus aureus...
May 31, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29802619/antitumor-triterpenoid-saponin-from-the-fruits-of-avicennia-marina
#12
Xiong-Wu Yang, Zhi Dai, Bei Wang, Ya-Ping Liu, Xu-Dong Zhao, Xiao-Dong Luo
The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China. As a part of our continuous effort to search for bioactive molecules from the plant, the fruits of A. marina were investigated, which has led to one new triterpenoid saponin (1) and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data. The new triterpenoid saponin showed cytotoxicity against GSC-3# and GSC-18# with the IC50 values were 12...
May 25, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29790088/three-new-heptelidic-acid-derivatives-from-the-culture-of-mushroom-lentinellus-ursinus
#13
Li Liu, Jun-Jie Han, Tian-Shun Xu, Rui-Xing Liu, Li Bao, Hong-Wei Liu
Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.
May 22, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29754315/three-new-indole-alkaloids-from-tabernaemontana-divaricata
#14
Yan Deng, Mei-Fen Bao, Bao-Bao Shi, Jing Wu, Xiang-Hai Cai
Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC50  > 20 µM).
May 12, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29744736/compounds-from-african-medicinal-plants-with-activities-against-selected-parasitic-diseases-schistosomiasis-trypanosomiasis-and-leishmaniasis
#15
REVIEW
Conrad V Simoben, Fidele Ntie-Kang, Sergi H Akone, Wolfgang Sippl
Parasitic diseases continue to represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases. In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species...
May 9, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29777503/anti-tmv-effects-of-amaryllidaceae-alkaloids-isolated-from-the-bulbs-of-lycoris-radiata-and-lycoricidine-derivatives
#16
Dong-Qiong Yang, Zhao-Rong Chen, Duo-Zhi Chen, Xiao-Jiang Hao, Shun-Lin Li
Fifteen known amaryllidaceae alkaloids were isolated from the bulbs of Lycoris radiata. Some of the compounds and lycoricidine derivatives had been screened for the activities against tobacco mosaic virus (TMV) by the conventional half-leaf method. Lycoricidine derivatives were also carried out the assay of effect on systemic infection of TMV by western-blot and RT-PCR analysis. The tested compounds showed moderate inactivation effect, whereas the lycoricidine derivatives showed good protective effect. The protective inhibitory activity of compounds L1 (N-methyl-2,3,4-trimethoxylycoricidine) (60...
June 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29722004/meroterpenoids-from-ganoderma-species-a-review-of-last-five-years
#17
REVIEW
Xingrong Peng, Minghua Qiu
Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. Ganoderma meroterpenoids (GMs) are a type of meroterpenoids containing a 1,2,4-trisubstituted phenyl and a polyunsaturated terpenoid part. Over last 5 years, great efforts have been made to conduct phytochemistry research on the genus Ganoderma, which have led to the isolation and identification of a number of GMs. These newly reported GMs showed diverse structures and a wide range of biological activities. This review gives an overview of new GMs from genus Ganoderma and their biological activities and biosynthetic pathway, focusing on the period from 2013 until 2018...
June 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29633187/lycoplanines-b-d-three-lycopodium-alkaloids-from-lycopodium-complanatum
#18
Zhi-Jun Zhang, Qin-Feng Zhu, Jia Su, Xing-De Wu, Qin-Shi Zhao
A novel C17 N Lycopodium alkaloid (LA), lycoplanine B (1), containing an unusual formyl group, along with two new LAs, lycoplanines C (2) and D (3), were isolated from the whole plant of Lycopodium complanatum. Their structures were elucidated by extensive NMR techniques, including 1D- and 2D-NMR experiments, as well as comparing their spectral data with those of the known analogues. A possible biogenetic pathway for 1 was also proposed.
June 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29594954/irpexoates-a-d-four-triterpenoids-with-malonyl-modifications-from-the-fruiting-bodies-of-the-medicinal-fungus-irpex-lacteus
#19
Yang Tang, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, He-Ping Chen, Ji-Kai Liu
Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A-D (1-4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS spectroscopic analysis. Irpexoate B (2) displayed weak cytotoxicity against four human cancer cell lines (A-549, SMMC-7721, MCF-7, SW480) with IC50 values varying from 22.9 to 34.0 μM, and irpexoate D (4) showed weak cytotoxicity against the human cancer cell line SW480 with an IC50 value of 35...
June 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29633188/antitumor-research-on-artemisinin-and-its-bioactive-derivatives
#20
REVIEW
Yunqin Zhang, Guowei Xu, Shuqun Zhang, Dong Wang, P Saravana Prabha, Zhili Zuo
Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment...
April 9, 2018: Natural Products and Bioprospecting
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