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Natural Products and Bioprospecting

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https://www.readbyqxmd.com/read/30151716/progress-on-the-chemical-constituents-derived-from-glucosinolates-in-maca-lepidium-meyenii
#1
REVIEW
Yan-Jie Huang, Xing-Rong Peng, Ming-Hua Qiu
Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before. Recently, a series of novel thiohydantoins which generally exhibit a variety of activities have been isolated from Maca. This review focuses on the progress on the main bioactive components of Maca and their biosynthetic pathway, which indicates that macamides, thiohydantoins, and some alkaloids may originate from glucosinolates...
August 27, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/30128843/new-dammarane-triterpenoids-caffruones-a-d-from-the-cherries-of-coffea-arabica
#2
Xia Wang, Xing-Rong Peng, Jing Lu, Gui-Lin Hu, Ming-Hua Qiu
In present study, four new dammarane-type triterpenoids, namely caffruones A-D (1-4), were isolated from the cherries of Coffea arabica. Their structures were elucidated by extensive spectroscopic analysis including 1D, 2D NMR (HSQC, HMBC, 1 H-1 H COSY, and ROESY), HRMS and IR spectra. This is the first time that tetracyclic triterpenes have been reported in genus Coffea.
August 20, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/30073582/amides-isoquinoline-alkaloids-and-dipeptides-from-the-aerial-parts-of-piper-mullesua
#3
Meng-Yuan Xia, Jun Yang, Pan-Hua Zhang, Xiao-Nian Li, Ji-Feng Luo, Chun-Lin Long, Yue-Hu Wang
One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A-F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data. Furthermore, the structures of pipermullesines A-C were confirmed by single crystal X-ray diffraction analysis. All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin (IIa) or platelet-activating factor (PAF)...
August 2, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29934731/medicinal-plant-using-ground-state-stabilization-of-natural-antioxidant-curcumin-by-keto-enol-tautomerisation
#4
S Manimaran, K SambathKumar, R Gayathri, K Raja, N Rajkamal, M Venkatachalapathy, G Ravichandran, C Lourdu EdisonRaj
Curcumin is a medicinal agent that exhibits anti-cancer properties and bioactive pigment in Turmeric has a huge therapeutic value. It has a keto-enol moiety that gives rise to many of its chemical properties. A recent study has shown that keto-enol tautomerisation at this moiety is implicated the effect of curcumin. The tautomerisation of curcumin in methanol, acetone and acetonitrile are used in nuclear magnetic resonance (1 H, 13 C) spectroscopy. It was characterized using UV, IR and Raman spectral values...
June 22, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/30069678/fruits-as-prospective-reserves-of-bioactive-compounds-a-review
#5
REVIEW
Marines Marli Gniech Karasawa, Chakravarthi Mohan
Bioactive natural products have always played a significant role as novel therapeutical agents irrespective of their source of origin. They have a profound effect on human health by both direct and indirect means and also possess immense medicinal properties. Fruit species are largely appreciated and highly consumed throughout the world. Epidemiologic information supports the association between high intake of fruits and low risk of chronic diseases. There are several biological reasons why the consumption of fruits might reduce or prevent chronic diseases...
October 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29855857/-%C3%A2-zanthonitidine-a-a-pair-of-enantiomeric-furoquinoline-alkaloids-from-zanthoxylum-nitidum-with-antibacterial-activity
#6
Li-Na Zhao, Xi-Xi Guo, Shuai Liu, Li Feng, Qi-Rui Bi, Zhe Wang, Ning-Hua Tan
A pair of new enantiomeric furoquinoline alkaloids, (±)-zanthonitidine A (1), together with nine known ones (2-10) were isolated from the radix of Zanthoxylum nitidum. Their chemical structures were elucidated based on the extensive spectroscopic analysis. The racemic mixture of 1 was separated by chiral column chromatography, and the absolute configurations of (+)-1 and (-)-1 were determined by the comparison of experimental and calculated electronic circular dichroism spectra. Antibacterial activities of compounds 1-9 were evaluated, and compounds (+)-1, (-)-1, 3, 7 and 8 showed antibacterial activities against Bacillus subtilis, Enterococcus faecalis or Staphylococcus aureus...
October 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29802619/antitumor-triterpenoid-saponin-from-the-fruits-of-avicennia-marina
#7
Xiong-Wu Yang, Zhi Dai, Bei Wang, Ya-Ping Liu, Xu-Dong Zhao, Xiao-Dong Luo
The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China. As a part of our continuous effort to search for bioactive molecules from the plant, the fruits of A. marina were investigated, which has led to one new triterpenoid saponin (1) and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data. The new triterpenoid saponin showed cytotoxicity against GSC-3# and GSC-18# with the IC50 values were 12...
October 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29790088/three-new-heptelidic-acid-derivatives-from-the-culture-of-mushroom-lentinellus-ursinus
#8
Li Liu, Jun-Jie Han, Tian-Shun Xu, Rui-Xing Liu, Li Bao, Hong-Wei Liu
Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.
October 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/30032475/an-explorer-of-chemical-biology-of-plant-natural-products-in-southwest-china-xiaojiang-hao
#9
REVIEW
Yue-Mao Shen, Duo-Zhi Chen
Xiaojiang Hao, who obtained Master Degree from Kunming Institute of Botany (KIB), Chinese Academy of Sciences (CAS) in 1985, and Doctor in Pharmacy degree in Pharmacy from Institute for Chemical Research, Kyoto University, in 1990, was born in Chongqing in July, 1951. In 1991, he returned to KIB, CAS, as an Associate professor and served as the chair of the Department of Phytochemistry. In 1994, he was promoted to a full professor at the current institute. He served as the Deputy Director of KIB and the Director of Open Laboratory of Phytochemistry from 1995 to 1997, and the Director of KIB from 1997 to 2005...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/30027529/harvest-after-50-years-of-sowing
#10
REVIEW
Pema-Tenzin Puno
No abstract text is available yet for this article.
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/30014450/affiliation-with-natural-products-at-kib-of-prof-zhou-jun-on-the-occasion-of-80th-anniversary-of-kunming-institute-of-botany-cas
#11
REVIEW
Jiang-Miao Hu
Prof. Zhou Jun, Academician of Chinese Academy of Sciences (1999), is a phytochemist and medicinal chemist of China. He is one of the pioneers of Kunming Institute of Botany, CAS and a major founder of the State Key Laboratory of Phytochemistry and Plant Resources in West China. The chemical compositions of some TCM from genus of Dioscorea, Aconitum, Panax, Paris, Cynanchum, Gastrodia, Dendrobium etc. and family Asclepiadaceae, Caryophyllaceae, Hypoxidaceae etc. have been explored by Prof. Zhou's team as steroids, triterpenoids, alkaloids, cyclic peptides and phenols etc...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29980943/research-of-panax-spp-in-kunming-institute-of-botany-cas
#12
REVIEW
Yi-Jun Qiao, Jia-Huan Shang, Dong Wang, Hong-Tao Zhu, Chong-Ren Yang, Ying-Jun Zhang
Panax, a genus of the Araliaceae family, is an important herbal group in traditional Chinese medicine (TCM). Nine species and three varieties are included in the genus of Panax, in which nearly all species have been used for medicinal purposes. Among them, Panax notoginseng (Burk) F. H. Chen, Panax ginseng C. A. Meyer and Panax quinquefolius L. are the most representative and valuable herbs world-wide, with a long history of cultivation. As the main bioactive chemical constituents, saponins with different aglycones are the major components in various Panax spp...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29978386/the-progress-of-anti-hbv-constituents-from-medicinal-plants-in-china
#13
REVIEW
Chang-An Geng, Ji-Jun Chen
Hepatitis B virus (HBV) infection causing acute and chronic hepatitis is a serious problem worldwide, whereas the current treatment methods are unsatisfactory. Traditional Chinese herbs that have long been used for medicinal purposes are fascinating sources for novel anti-HBV candidates. This paper summarizes the progress of anti-HBV constituents from diverse medicinal plants in China to provide information for searching new anti-HBV drugs from natural sources.
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29974350/untiring-researches-for-alternative-resources-of-rhizoma-paridis
#14
REVIEW
Xu-Jie Qin, Wei Ni, Chang-Xiang Chen, Hai-Yang Liu
Rhizoma Paridis (RP, ), a traditional Chinese medicine, is the rhizoma of Paris polyphylla var. yunnanensis (PPY) or P. polyphylla var. chinensis which are widely used as important raw materials for several Chinese patent drugs. However, the wild resources of these herbs have become less and less due to their slow-growing characteristics and previously excessive excavation. This review covers untiring investigations on alternative resources of RP by our research group over the past decades, including non-medicinal parts of PPY as well as other plants of Liliaceae and Liliflorae families...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29974338/small-molecule-targets-in-tumor-immunotherapy
#15
REVIEW
Hui-Fang Zhu, Yan Li
Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success of targeting the T cell immune checkpoint receptors PD-1 or CTLA4 by antibodies blockade in advanced stages of cancers has demonstrated the importance of immune modulation. But antibodies-based immunotherapy confronted with some disadvantages, such as immunogenicity, stability, membrane permeability, and production cost...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29959744/application-of-metabolomics-in-the-study-of-natural-products
#16
Qi Zhao, Jia-Le Zhang, Fei Li
LC-MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro and in vivo metabolism of natural compounds, such as osthole, dehydrodiisoeugenol, and myrislignan. The pharmacological effects of natural compounds and extracts were determined using metabolomics technology combined with diseases models in animal, including osthole and nutmeg extracts...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29943349/residual-dipolar-couplings-in-structure-determination-of-natural-products
#17
REVIEW
Gao-Wei Li, Han Liu, Feng Qiu, Xiao-Juan Wang, Xin-Xiang Lei
The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will provide a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29633188/antitumor-research-on-artemisinin-and-its-bioactive-derivatives
#18
REVIEW
Yunqin Zhang, Guowei Xu, Shuqun Zhang, Dong Wang, P Saravana Prabha, Zhili Zuo
Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment...
August 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29915912/two-new-alkaloids-from-fusarium-tricinctum-sypf-7082-an-endophyte-from-the-root-of-panax-notoginseng
#19
Wen-Jie Sun, Hong-Tao Zhu, Tian-Yuan Zhang, Meng-Yue Zhang, Dong Wang, Chong-Ren Yang, Yi-Xuan Zhang, Ying-Jun Zhang
Panax notoginseng (Araliaceae) is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of China. Two new alkaloids, rigidiusculamide E (1) and [-(α-oxyisohexanoyl-N-methyl-leucyl)2 -] (2), together with two known ones, (-)-oxysporidinone (3) and (-)-4,6'-anhydrooxysporidinone (4) were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082, an endophytic fungus obtained from the healthy root of P. notoginseng. Their structures were determined on the basis of extensive spectroscopic analyses...
June 18, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29909523/synthesis-and-cytotoxicities-of-royleanone-derivatives
#20
Cheng-Ji Li, Fan Xia, Rong Wu, Hong-Sheng Tan, Hong-Xi Xu, Gang Xu, Hong-Bo Qin
Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.
June 16, 2018: Natural Products and Bioprospecting
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