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Natural Products and Bioprospecting

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https://www.readbyqxmd.com/read/28194725/otophylloside-b-protects-against-a%C3%AE-toxicity-in-caenorhabditis-elegans-models-of-alzheimer-s-disease
#1
Jie Yang, Xiao-Bing Huang, Qin-Li Wan, Ai-Jun Ding, Zhong-Lin Yang, Ming-Hua Qiu, Hua-Ying Sun, Shu-Hua Qi, Huai-Rong Luo
Alzheimer's disease (AD) is a major public health concern worldwide and the few drugs currently available only treat the symptoms. Hence, there is a strong need to find more effective anti-AD agents. Cynanchum otophyllum is a traditional Chinese medicine for treating epilepsy, and otophylloside B (Ot B), isolated from C. otophyllum, is the essential active component. Having previously identified anti-aging effects of Ot B, we evaluated Ot B for AD prevention in C. elegans models of AD and found that Ot B extended lifespan, increased heat stress-resistance, delayed body paralysis, and increased the chemotaxis response...
February 13, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28132388/quebrachitol-global-status-and-basic-research
#2
REVIEW
Dong Wang, Shuqun Zhang, Zhe Chang, De-Xin Kong, Zhili Zuo
Recently, there has been a renewed interest in the natural-products-inspired drugs. Quebrachitol (QCT) is one of naturally occurring optically active cyclitols that has now received considerable attention. Until the last decade, it came to be a starting point for the lead discovery. In this review, we had a discussion on the basic research of QCT, including its source, structure, properties, and the recent advances on its application. The biological activities and QCT-inspired leads that are potentially effective for treating human diseases were also discussed...
January 28, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28110438/polysubstituted-isoflavonoids-from-spatholobus-suberectus-flemingia-macrophylla-and-cudrania-cochinchinensis
#3
Li-Xia Wang, Hai-Rong Zheng, Fu-Cai Ren, Tian-Ge Chen, Xiang-Mei Li, Xian-Jun Jiang, Fei Wang
Four hitherto unknown polysubstituted isoflavonoids, including three isoflavans: 7,4'-dihydroxy-8,2',3'-trimethoxyisoflavan (1), 7,2',4'-trihydroxy-8,3'-dimethoxyisoflavan (2), and 7,2',4'-trihydroxy-5-methoxyisoflavan (3), and one prenylated isoflavone cudraisoflavone M (4) were isolated from the ethanol extracts of Spatholobus suberectus (for 1 and 2), Flemingia macrophylla (for 3), and Cudrania cochinchinensis (for 4), respectively. Their structures were established on the basis of extensive spectroscopic analysis...
January 21, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28097641/natural-products-diversity-of-marine-ascidians-tunicates-ascidiacea-and-successful-drugs-in-clinical-development
#4
REVIEW
Satheesh Kumar Palanisamy, N M Rajendran, Angela Marino
This present study reviewed the chemical diversity of marine ascidians and their pharmacological applications, challenges and recent developments in marine drug discovery reported during 1994-2014, highlighting the structural activity of compounds produced by these specimens. Till date only 5% of living ascidian species were studied from <3000 species, this study represented from family didemnidae (32%), polyclinidae (22%), styelidae and polycitoridae (11-12%) exhibiting the highest number of promising MNPs...
January 17, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28093670/natural-colorants-historical-processing-and-sustainable-prospects
#5
REVIEW
Mohd Yusuf, Mohd Shabbir, Faqeer Mohammad
With the public's mature demand in recent times pressurized the textile industry for use of natural colorants, without any harmful effects on environment and aquatic ecosystem, and with more developed functionalities simultaneously. Advanced developments for the natural bio-resources and their sustainable use for multifunctional clothing are gaining pace now. Present review highlights historical overview of natural colorants, classification and predominantly processing of colorants from sources, application on textiles surfaces with the functionalities provided by them...
January 16, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28064425/enantioselective-resolution-of-r-s-carvedilol-to-s-carvedilol-by-biocatalysts
#6
Swetha Ettireddy, Vijitha Chandupatla, Ciddi Veeresham
Among the microorganisms employed in the study, Aspergillus niger (GUFCC5443), Escherichia coli (ATCC9637), Streptomyces halstedii (CKM-2), Pseudomonas putida (NCIB9494), Cunninghamella elegans (NCIM689) and Sphingomonas paucimobilis (NCTC11030) were capable for the enantioselective conversion of racemic Carvedilol. Immobilization technique enhanced the enantioselectivity of microorganisms and thus increased the enantiomeric purity of the drug. Excellent enantiomeric ratios (E) were found in reactions catalyzed by immobilized A...
January 7, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28063119/seco-sativene-and-seco-longifolene-sesquiterpenoids-from-cultures-of-endophytic-fungus-bipolaris-eleusines
#7
Man-Si Yang, Xiao-Yue Cai, Yuan-Yuan He, Meng-Ying Lu, Shuang Liu, Wen-Xiang Wang, Zheng-Hui Li, Hong-Lian Ai, Tao Feng
Two new seco-sativene sesquiterpenoids, bipolenins D (1) and E (2), a new seco-longifolene sesquiterpenoid, bipolenin F (3), together with three known analogues (4-6), were obtained from cultures of endophytic fungus Bipolaris eleusines. Their structures were established by MS and NMR data. Compounds 1-6 showed no activity to five human cancer cell lines.
January 6, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28054247/pharmacological-and-predicted-activities-of-natural-azo-compounds
#8
Valery M Dembitsky, Tatyana A Gloriozova, Vladimir V Poroikov
This paper describes research on natural azo compounds isolated from fungi, plant, bacteria, and invertebrates. More than 120 biologically active diazene containing alkaloids demonstrate confirmed pharmacological activity, including antitumor, antimicrobial, and antibacterial effects. The structures, origin, and biological activities of azo compounds are reviewed. Utilizing the computer program PASS, some structure-activity relationship new activities are also predicted, pointing toward possible new applications of these compounds...
January 4, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27873184/-%C3%A2-evodiakine-a-pair-of-rearranged-rutaecarpine-type-alkaloids-from-evodia-rutaecarpa
#9
Yan-Hong Li, Yu Zhang, Li-Yan Peng, Xiao-Nian Li, Qin-Shi Zhao, Rong-Tao Li, Xing-De Wu
(±)-Evodiakine (1a and 1b), a pair of rearranged rutaecarpine-type alkaloids with an unprecedented 6/5/5/7/6 ring system, were isolated from the nearly ripe fruits of Evodia rutaecarpa. Separation of the enantiomers have been achieved by chiral HPLC column. The structures of (±)-evodiakine were unambiguously elucidated by 1D and 2D NMR spectra, mass spectrometry, and single-crystal X-ray diffraction. Their absolute configurations were determined by comparison of experimental and calculated electronic circular dichroism spectra...
December 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27844233/a-fragmentation-study-on-four-unusual-secoiridoid-trimers-swerilactones-h-k-by-electrospray-tandem-mass-spectrometry
#10
Chang-An Geng, Ji-Jun Chen
Swerilactones H-K (1-4) as four unprecedented secoiridoid trimers represent a new type of natural product, which has attracted much interest of natural chemists due to their novel skeletons and promising bioactivity. In order to well understand their MS fragmentation behaviors, they were investigated by electrospray ionization ion-trap time-of-flight multistage product ion mass spectrometry (ESI-IT-TOF-MS (n) ) for the first time. The protonated molecules ([M+H](+)) of swerilactones J and K, and deprotonated molecules ([M-H](-)) of swerilactones H, J and K were readily observed in the conventional single-stage mass spectra (MS); however only the [M+Cl](-) ion for swerilactone I was obtained in negative mode...
December 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27830475/indole-glycosides-from-aqueous-fraction-of-strychnos-nitida
#11
Bei Wang, Zhi Dai, Lu Liu, Xin Wei, Pei-Feng Zhu, Hao-Fei Yu, Ya-Ping Liu, Xiao-Dong Luo
Three new indole glycosides 22-deoxystrictosamide (1), 22-deoxystrictosamide N (b)-oxide (2) and vincosamide 2'-O-β-D-xylopyranoside-11-O-β-D-glucopyranoside (3), together with four known analogues were isolated from aqueous fraction of Strychnos nitida. Their structures were elucidated on the basis of extensive analysis of spectroscopic data. All the alkaloids were tested for their cytotoxic activity, but they did not show any exciting result.
December 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27783309/lyconadins-g-and-h-two-rare-lyconadin-type-lycopodium-alkaloids-from-lycopodium-complanatum
#12
Jin-Tang Cheng, Zhi-Jun Zhang, Xiao-Nian Li, Li-Yan Peng, Huai-Rong Luo, Xing-De Wu, Qin-Shi Zhao
Two rare lyconadin-type Lycopodium alkaloids, lyconadins G (1) and H (2), together with four known ones (3-6), were isolated from Lycopodium complanatum. The structures were determined on the basis of their spectroscopic analyses, and the absolute configuration of 1 was established by an X-ray crystallographic analysis. It is the first time to establish the absolute configuration of lyconadin-type Lycopodium alkaloid by an X-ray diffraction experiment. In addition, these findings may provide more information for the biosynthesis of lyconadins...
December 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27757926/acetylcholinesterase-and-cytotoxic-activity-of-chemical-constituents-of-clutia-lanceolata-leaves-and-its-molecular-docking-study
#13
Mehtab Parveen, Faheem Ahmad, Ali Mohammed Malla, Shaista Azaz, Mahboob Alam, Omer A Basudan, Manuela Ramos Silva, Pedro S Pereira Silva
Phytochemical investigations of the ethanolic extract of leaves of Clutia lanceolata (Family: Euphorbiaceae) resulted in the isolation of four compounds viz. 3,4-dihydroxy-2-methylbenzoic acid (1), 2,2'-dihydroxy-1,1'-binaphthyl (2), 1,3,8-trihydroxy-6-methylanthracene-9,10-dione (3) and 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one (4). Although all the isolated compounds were known but this was the first report from this plant source. Their structures were established on the basis of chemical and physical evidences viz...
December 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27757925/lactam-triterpenoids-from-the-bark-of-toona-sinensis
#14
Qian-Qian Meng, Xing-Rong Peng, Shuang-Yang Lu, Luo-Sheng Wan, Xia Wang, Jin-Run Dong, Rui Chu, Lin Zhou, Xiao-Nian Li, Ming-Hua Qiu
Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities...
October 18, 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27752986/clerodane-diterpenoids-with-anti-hyperglycemic-activity-from-tinospora-crispa
#15
Yuan Gao, Yan-Fen Niu, Fei Wang, Ping Hai, Fang Wang, Yin-Dong Fang, Wen-Yong Xiong, Ji-Kai Liu
Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice...
October 17, 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27655634/furoquinoline-alkaloids-and-methoxyflavones-from-the-stem-bark-of-melicope-madagascariensis-baker-t-g-hartley
#16
Vincent E Rasamison, Peggy J Brodie, Emilio F Merino, Maria B Cassera, Michel A Ratsimbason, Stephan Rakotonandrasana, Andriamalala Rakotondrafara, Elie Rafidinarivo, David G I Kingston, Harinantenaina L Rakotondraibe
Melicope madagascariensis (Rutaceae) is an endemic plant species of Madagascar that was first classified as a member of the genus Euodia J. R. & G. Forst (Rutaceae) under the scientific name Euodia madagascariensis Baker. Based on morphological characteristics, Thomas Gordon Hartley taxonomically revised E. madagascariensis Baker to be M. madagascariensis (Baker) T.G. Hartley. Chemotaxonomical studies have long been used to help the identification and confirmation of taxonomical classification of plant species and botanicals...
October 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27646268/prenylated-coumarins-from-heracleum-stenopterum-peucedanum-praeruptorum-clausena-lansium-and-murraya-paniculata
#17
Xiang-Mei Li, Xian-Jun Jiang, Ku Yang, Li-Xia Wang, Shi-Zhen Wen, Fei Wang
Four hitherto unknown prenylated coumarins, namely 6″-O-β-D-apiofuranosylapterin (1), 4'-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC50 values ranging from 15...
September 19, 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27565150/hirsutane-sesquiterpenes-from-cultures-of-the-basidiomycete-marasmiellus-sp-bcc-22389
#18
Masahiko Isaka, Somporn Palasarn, Malipan Sappan, Sumalee Supothina, Thitiya Boonpratuang
Two new hirsutane sesquiterpenes, marasmiellins A (1) and B (2), were isolated from cultures of the basidiomycete Marasmiellus sp. BCC 22389. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of marasmiellin B was determined by application of the modified Mosher's method.
August 26, 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27379497/sesquiterpenoids-from-the-rhizomes-of-homalomena-occulta
#19
Jun-Li Yang, Ya-Min Zhao, Yan-Ping Shi
Naturally occurring oplopanane sesquiterpenoids are rarely reported. A phytochemical investigation on the rhizomes of Homalomena occulta (Lours) has resulted in the discovery of six oplopanane sesquiterpenoids (1-6), including four new (1-4) and one 3,5-seco-oplopanane (6), together with three previously reported sesquiterpenoids (7-9). In addition three new oplopananes (2a-4a) were also obtained by chemical transformation. All structures of these sesquiterpenoids were established based on the comprehensive spectroscopic analyses, including NMR, MS, and IR, and comparing with the literatures...
August 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27318495/spiralosides-a-c-three-new-c27-steroidal-glycoalkaloids-from-the-fruits-of-solanum-spirale
#20
Dan Li, Yun-Li Zhao, Xu-Jie Qin, Lu Liu, Xing-Wei Yang, Ying-Ying Chen, Bei Wang, Xin Wei, Ya-Ping Liu, Xiao-Dong Luo
Three new C27-steroidal glycoalkaloids, spiralosides A-C (1-3), were obtained from the total alkaloids of Solanum spirale by chromatographic methods. On the basis of spectroscopic evidence, spiralosides A-C were elucidated as (22R,25S)-22,26-epiminocholest-5-ene-3β,16α-diol-N-acetyl-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl (1), (22R,25S)-22,26-epiminocholest-5-ene-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl (2), (22R,25S)-22,26-epiminocholest-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl (3), respectively...
August 2016: Natural Products and Bioprospecting
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