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Radiation Oncology Journal

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https://www.readbyqxmd.com/read/28893060/clinical-significance-of-the-lymph-node-ratio-in-n1-breast-cancer
#1
Jaeho Kim, Jin Hee Kim, Ok Bae Kim, Young Kee Oh, Seung Gyu Park
Purpose: The purpose of this study was to evaluate the prognostic value of the lymph node ratio (LNR), which was defined as the proportion of involved nodes of all dissected nodes, in pN1 breast cancer. Materials and Methods: We retrospectively analyzed the clinical data of patients with pN1 breast cancer (N = 144) treated at Keimyung University Dongsan Medical Center, Daegu, Korea between 2001 and 2010. The median age was 46 years (range, 27 to 66 years). The LNR was 0...
September 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28893059/dosimetric-advantages-and-clinical-outcomes-of-simultaneous-integrated-boost-intensity-modulated-radiotherapy-for-anal-squamous-cell-carcinoma
#2
Katsuyuki Sakanaka, Satoshi Itasaka, Yuichi Ishida, Kota Fujii, Takahiro Horimatsu, Takashi Mizowaki, Yoshiharu Sakai, Masahiro Hiraoka
Purpose: The purpose of this study was to explore the dosimetric difference between simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) and three-dimensional conformal radiotherapy (3DCRT), and the clinical outcomes of anal squamous cell carcinoma (ASCC) chemoradiotherapy featuring SIB-IMRT. Materials and Methods: This study included ten patients with ASCC who underwent chemoradiotherapy using SIB-IMRT with 5-fluorouracil and mitomycin C. SIB-IMRT delivered 54 Gy to each primary tumor plus metastatic lymph nodes and 45 Gy to regional lymph nodes, in 30 fractions...
September 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28881504/low-dose-radiation-therapy-for-massive-chylous-leakage-after-subtotal-gastrectomy
#3
Sang-Won Kim, Jung Hoon Kim
Massive chylous leakage is a rare postoperative complication that can prolong hospital stay and cause secondary morbidities. Conservative management strategies are the treatment of choice; however, radiation therapy (RT) can be used as an alternative for cases that are refractory to conservative treatment. Herein, we report a 69-year-old female patient who suffered from massive chylous leakage after subtotal gastrectomy. Due to persistent massive chylous leakage, she was scheduled to undergo low-dose RT. Radiation was delivered with a daily dose of 1 Gy, using an anterior-posterior and posterior-anterior beam arrangement...
September 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28881503/identification-of-cea-interacting-proteins-in-colon-cancer-cells-and-their-changes-in-expression-after-irradiation
#4
Byong Chul Yoo, Seung-Gu Yeo
Purpose: The serum carcinoembryonic antigen (CEA) level has been recognized as a prognostic factor in colorectal cancer, and associated with response of rectal cancer to radiotherapy. This study aimed to identify CEA-interacting proteins in colon cancer cells and observe post-irradiation changes in their expression. Materials and Methods: CEA expression in colon cancer cells was examined by Western blot analysis. Using an anti-CEA antibody or IgG as a negative control, immunoprecipitation was performed in colon cancer cell lysates...
September 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712283/stereotactic-radiotherapy-of-the-prostate-fractionation-and-utilization-in-the-united-states
#5
Joseph P Weiner, David Schwartz, Meng Shao, Virginia Osborn, Kwang Choi, David Schreiber
PURPOSE: To analyze the utilization and fractionation of extreme hypofractionation via stereotactic body radiotherapy (SBRT) in the treatment of prostate cancer. MATERIALS AND METHODS: Data was analyzed on men diagnosed with localized prostate cancer between 2004-2012 and treated with definitive-intent radiation therapy, as captured in the National Cancer Database. This database is a hospital-based registry that collects an estimated 70% of all diagnosed malignancies in the United States...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712282/deformable-image-registration-in-radiation-therapy
#6
REVIEW
Seungjong Oh, Siyong Kim
The number of imaging data sets has significantly increased during radiation treatment after introducing a diverse range of advanced techniques into the field of radiation oncology. As a consequence, there have been many studies proposing meaningful applications of imaging data set use. These applications commonly require a method to align the data sets at a reference. Deformable image registration (DIR) is a process which satisfies this requirement by locally registering image data sets into a reference image set...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712281/extraordinary-radiation-super-sensitivity-accompanying-with-sorafenib-combination-therapy-what-lies-beneath
#7
Jayoung Lee, Ju Hye Lee, Hanbin Yoon, Ho Jeong Lee, Hosang Jeon, Jiho Nam
Primary liver tumor, especially hepatocellular carcinoma (HCC), is a common cause of cancer death worldwide. The incidence is generally higher in Asian countries than in western countries. Carcinogenesis of HCC is often associated with hepatitis viral infections. Current standard treatment of HCC is surgical resection or transplantation in patients with early stage disease. However, the patient with advanced stage disease, surgical resection is often limited. Sorafenib or other treatment modalities are not so effective as well...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712280/radiation-for-persistent-or-recurrent-epithelial-ovarian-cancer-a-need-for-reassessment
#8
Noorie Choi, Ji Hyun Chang, Suzy Kim, Hak Jae Kim
PURPOSE: The role of radiotherapy (RT) was largely deserted after the introduction of platinum-based chemotherapy, but still survival rates are disappointingly low. This study focuses on assessing the clinical efficacy of RT in relation to chemotherapy resistance. MATERIALS AND METHODS: From October 2002 to January 2015, 44 patients were diagnosed with epithelial ovarian cancer (EOC) and treated with palliative RT for persistent or recurrent EOC. All patients received initial treatment with optimal debulking surgery and adjuvant platinum-based chemotherapy...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712279/the-role-of-adjuvant-external-beam-radiation-therapy-for-papillary-thyroid-carcinoma-invading-the-trachea
#9
Young Suk Kim, Jae Hyuck Choi, Kwang Sik Kim, Gil Chae Lim, Jeong Hong Kim, Ju Wan Kang, Hee-Sung Song, Sang Ah Lee, Chang Lim Hyun, Yunseon Choi, Gwi Eon Kim
PURPOSE: To evaluate the effect of adjuvant external beam radiation therapy (EBRT) on local failure-free survival rate (LFFS) for papillary thyroid cancer (PTC) invading the trachea. MATERIALS AND METHODS: Fifty-six patients with locally advanced PTC invading the trachea were treated with surgical resection. After surgery, 21 patients received adjuvant EBRT and radioactive iodine therapy (EBRT group) and 35 patients were treated with radioactive iodine therapy (control group)...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712278/in-vivo-dosimetry-and-acute-toxicity-in-breast-cancer-patients-undergoing-intraoperative-radiotherapy-as-boost
#10
Jason Joon Bock Lee, Jinhyun Choi, Sung Gwe Ahn, Joon Jeong, Ik Jae Lee, Kwangwoo Park, Kangpyo Kim, Jun Won Kim
PURPOSE: To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. MATERIALS AND METHODS: Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A total of 55 patients with a minimum follow-up of 1 month after WBI were evaluated...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712277/moderate-hypofractionated-image-guided-thoracic-radiotherapy-for-locally-advanced-node-positive-non-small-cell-lung-cancer-patients-with-very-limited-lung-function-a-case-report
#11
Farkhad Manapov, Olarn Roengvoraphoj, Minglun Li, Chukwuka Eze
Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second [FEV1] ≤ 1 L) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712276/optimal-dose-and-volume-for-postoperative-radiotherapy-in-brain-oligometastases-from-lung-cancer-a-retrospective-study
#12
Seung Yeun Chung, Jong Hee Chang, Hye Ryun Kim, Byoung Chul Cho, Chang Geol Lee, Chang-Ok Suh
PURPOSE: To evaluate intracranial control after surgical resection according to the adjuvant treatment received in order to assess the optimal radiotherapy (RT) dose and volume. MATERIALS AND METHODS: Between 2003 and 2015, a total of 53 patients with brain oligometastases from non-small cell lung cancer (NSCLC) underwent metastasectomy. The patients were divided into three groups according to the adjuvant treatment received: whole brain radiotherapy (WBRT) ± boost (WBRT ± boost group, n = 26), local RT/Gamma Knife surgery (local RT group, n = 14), and the observation group (n = 13)...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712275/predictive-factors-of-symptomatic-radiation-pneumonitis-in-primary-and-metastatic-lung-tumors-treated-with-stereotactic-ablative-body-radiotherapy
#13
Kangpyo Kim, Jeongshim Lee, Yeona Cho, Seung Yeun Chung, Jason Joon Bock Lee, Chang Geol Lee, Jaeho Cho
PURPOSE: Although stereotactic ablative body radiotherapy (SABR) is widely used therapeutic technique, predictive factors of radiation pneumonitis (RP) after SABR remain undefined. We aimed to investigate the predictive factors affecting RP in patients with primary or metastatic lung tumors who received SABR. MATERIALS AND METHODS: From 2012 to 2015, we reviewed 59 patients with 72 primary or metastatic lung tumors treated with SABR, and performed analyses of clinical and dosimetric variables related to symptomatic RP...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712274/stereotactic-body-radiation-therapy-for-liver-oligo-recurrence-and-oligo-progression-from-various-tumors
#14
Yu Jin Cha, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik
PURPOSE: To evaluate the outcomes of stereotactic body radiation therapy (SBRT) for patients with liver oligo-recurrence and oligo-progression from various primary tumors. MATERIALS AND METHODS: Between 2002 and 2013, 72 patients with liver oligo-recurrence (oligo-metastasis with a controlled primary tumor) and oligo-progression (contradictory progression of a few sites of disease despite an overall tumor burden response to therapy) underwent SBRT. Of these, 9 and 8 patients with uncontrollable distant metastases and patients immediate loss to follow-up, respectively, were excluded...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712273/effect-of-time-interval-between-capecitabine-intake-and-radiotherapy-on-local-recurrence-free-survival-in-preoperative-chemoradiation-for-locally-advanced-rectal-cancer
#15
Yeon Joo Kim, Jong Hoon Kim, Chang Sik Yu, Tae Won Kim, Se Jin Jang, Eun Kyung Choi, Jin Cheon Kim, Wonsik Choi
PURPOSE: The concentration of capecitabine peaks at 1-2 hours after administration. We therefore assumed that proper timing of capecitabine administration and radiotherapy would maximize radiosensitization and influence survival among patients with locally advanced rectal cancer. MATERIALS AND METHODS: We retrospectively reviewed 223 patients with locally advanced rectal cancer who underwent preoperative chemoradiation, followed by surgery from January 2002 to May 2006...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28395504/influence-of-jaw-tracking-in-intensity-modulated-and-volumetric-modulated-arc-radiotherapy-for-head-and-neck-cancers-a-dosimetric-study
#16
Karthick Raj Mani, Sagar Upadhayay, K J Maria Das
PURPOSE: To Study the dosimetric advantage of the Jaw tracking technique in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for Head and Neck Cancers. MATERIALS AND METHODS: We retrospectively selected 10 previously treated head and neck cancer patients stage (T1/T2, N1, M0) in this study. All the patients were planned for IMRT and VMAT with simultaneous integrated boost technique. IMRT and VMAT plans were performed with jaw tracking (JT) and with static jaw (SJ) technique by keeping the same constraints and priorities for a particular patient...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28395503/radiotherapy-for-locally-recurrent-rectal-cancer-treated-with-surgery-alone-as-the-initial-treatment
#17
Hidekazu Tanaka, Takahiro Yamaguchi, Kae Hachiya, Sunaho Okada, Masashi Kitahara, Katsuya Matsuyama, Masayuki Matsuo
PURPOSE: Although the technical developments of radiotherapy have been remarkable, there are currently few reports on the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as initial treatment in this three-dimensional conformal radiotherapy era. Thus, we retrospectively evaluated the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as the initial treatment. MATERIALS AND METHODS: Thirty-two patients who underwent radiotherapy were enrolled in this study...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28395502/reirradiation-of-head-and-neck-cancer-in-the-era-of-intensity-modulated-radiotherapy-patient-selection-practical-aspects-and-current-evidence
#18
REVIEW
Yeon Sil Kim
Locoregional failure is the most frequent pattern of failure in locally advanced head and neck cancer patients and it leads to death in most of the patients. Second primary tumors occurring in the other head and neck region reach up to almost 40% of long-term survivors. Recommended and preferred retreatment option in operable patients is salvage surgical resection, reporting a 5-year overall survival of up to 40%. However, because of tumor location, extent, and underlying comorbidities, salvage surgery is often limited and compromised by incomplete resection...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28395501/multidisciplinary-team-approach-for-the-management-of-patients-with-locally-advanced-non-small-cell-lung-cancer-searching-the-evidence-to-guide-the-decision
#19
REVIEW
In-Jae Oh, Sung-Ja Ahn
Locally advanced non-small cell lung cancer (LA-NSCLC) is composed of heterogeneous subgroups that require a multidisciplinary team approach in order to ensure optimal therapy for each patient. Since 2010, the National Comprehensive Cancer Network has recommended chemoradiation therapy (CRT) for bulky mediastinal disease and surgical combination for those patients with single-station N2 involvement who respond to neoadjuvant therapy. According to lung cancer tumor boards, thoracic surgeons make a decision on the resectability of the tumor, if it is determined to be unresectable, concurrent CRT (CCRT) is considered the next choice...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28292006/radiotherapy-in-prostate-cancer-treatment-results-of-the-patterns-of-care-study-in-korea
#20
Ah Ram Chang, Won Park
PURPOSE: The purpose of this study was to describe treatment patterns of radiotherapy (RT) for prostate cancer in Korea. MATERIALS AND METHODS: A questionnaire about radiation treatment technique and principles in 2013 was sent to 83 radiation oncologists and data from 57 hospitals were collected analyzed to find patterns of RT for prostate cancer patients in Korea. RESULTS: The number of patients with prostate cancer treated with definitive RT ranged from 1 to 72 per hospital in 2013...
March 2017: Radiation Oncology Journal
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