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Radiation Oncology Journal

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https://www.readbyqxmd.com/read/27927012/nodal-tumor-response-according-to-the-count-of-peripheral-blood-lymphocyte-subpopulations-during-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#1
Jaesung Heo, Young-Taek Oh, O Kyu Noh, Mison Chun, Jun-Eun Park, Sung-Ran Cho
Purpose: The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. Materials and Methods: From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy...
December 12, 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27927011/clinical-outcomes-in-patients-treated-with-radiotherapy-after-surgery-for-cervical-cancer
#2
Kyungmi Yang, Won Park, Seung Jae Huh, Duk-Soo Bae, Byoung-Gie Kim, Jeong-Won Lee
Purpose: The purpose of this study was to analyze clinical outcomes from cervical cancer and stratify patients into risk groups for prognostic factors for early-stage disease. Materials and Methods: We retrospectively reviewed patients with stage IB or IIA cervical cancer treated with adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) following primary surgery at Samsung Medical Center from 2001 to 2011. Adjuvant RT was added for patients with intermediate-risk factors, and adjuvant CCRT was performed on high-risk patients after surgery...
December 12, 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27703126/treatment-outcomes-after-adjuvant-radiotherapy-following-surgery-for-patients-with-stage-i-endometrial-cancer
#3
Jiyoung Kim, Kyung-Ja Lee, Kyung-Ran Park, Boram Ha, Yi-Jun Kim, Wonguen Jung, Rena Lee, Seung Cheol Kim, Hye Sung Moon, Woong Ju, Yun Hwan Kim, Jihae Lee
Purpose: The purpose of this study is to evaluate the treatment outcomes of adjuvant radiotherapy using vaginal brachytherapy (VB) with a lower dose per fraction and/or external beam radiotherapy (EBRT) following surgery for patients with stage I endometrial carcinoma. Materials and Methods: The subjects were 43 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer who underwent adjuvant radiotherapy following surgery between March 2000 and April 2014...
October 5, 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27609110/the-impact-of-radiotherapy-on-clinical-outcomes-in-parameningeal-rhabdomyosarcoma
#4
Yunseon Choi, Do Hoon Lim
Purpose: Radiotherapy (RT) is considered a mainstay of treatment in parameningeal rhabdomyosarcoma (PM-RMS). We aim to determine the treatment outcomes and prognostic factors for PM-RMS patients who treated with RT. In addition, we tried to evaluate the adequate dose and timing of RT. Materials and Methods: Twenty-two patients with PM-RMS from 1995 to 2013 were evaluated. Seven patients had intracranial extension (ICE) and 17 patients had skull base bony erosion (SBBE)...
September 13, 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730805/application-of-radiotherapy-for-hepatocellular-carcinoma-in-current-clinical-practice-guidelines
#5
REVIEW
Chai Hong Rim, Jinsil Seong
In oncologic practice, treatment guidelines provide appropriate treatment strategies based on evidence. Currently, many guidelines are used, including those of the European Association for the Study of the Liver and European Organization for Research and Treatment of Cancer (EASL-EORTC), National Comprehensive Cancer Network (NCCN), Asia-Pacific Primary Liver Cancer Expert (APPLE), and Korean Liver Cancer Study Group and National Cancer Centre (KLCSG-NCC). Although radiotherapy is commonly used in clinical practice, some guidelines do not accept it as a standard treatment modality...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730804/preoperative-chemoradiotherapy-followed-by-local-excision-in-clinical-t2n0-rectal-cancer
#6
Young Seob Shin, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Tae Won Kim, Heung Moon Chang, Jin-Hong Park, Seung Do Ahn, Sang-Wook Lee, Eun Kyung Choi, Jin Cheon Kim, Jong Hoon Kim
PURPOSE: To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients. MATERIALS AND METHODS: Patients who received PCRT and LE because of clinical T2 rectal cancer within 7 cm from anal verge between January 2006 and June 2014 were retrospectively analyzed. LE was performed in case of a good clinical response after PCRT. Patients' characteristics, treatment record, tumor recurrence, and treatment-related complications were reviewed at a median follow-up of 49 months...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730803/radiation-therapy-for-gastric-mucosa-associated-lymphoid-tissue-lymphoma-dose-volumetric-analysis-and-its-clinical-implications
#7
Hyeon Woo Lim, Tae Hyun Kim, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Soo Jeong Cho, Hyeon Seok Eom, Sung Ho Moon, Dae Yong Kim
PURPOSE: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness of involved field RT with moderate-dose and to evaluate the benefit of 3D-CRT comparing with 2D-RT. MATERIALS AND METHODS: Between July 2003 and March 2015, 33 patients with stage IE and IIE gastric MALT lymphoma received RT were analyzed...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730802/retroperitoneal-liposarcoma-the-role-of-adjuvant-radiation-therapy-and-the-prognostic-factors
#8
Hong Seok Lee, Jeong Il Yu, Do Hoon Lim, Sung Joo Kim
PURPOSE: To evaluate the benefit of adjuvant radiation therapy (RT) for retroperitoneal liposarcoma (RPLS) following gross tumor removal. MATERIALS AND METHODS: We reviewed 77 patients with primary RPLS surgically treated between January 2000 and December 2013. Cases with gross residual disease were excluded. Tumor grade was evaluated according to the French Federation of Cancer Centers Sarcoma Group (FNCLCC) system. Adjuvant RT was delivered to 32 patients (42%) using external beam RT alone...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730801/comparison-of-concurrent-chemoradiotherapy-versus-sequential-radiochemotherapy-in-patients-with-completely-resected-non-small-cell-lung-cancer
#9
Hwan-Ik Kim, O Kyu Noh, Young-Taek Oh, Mison Chun, Sang-Won Kim, Oyeon Cho, Jaesung Heo
PURPOSE: Our institution has implemented two different adjuvant protocols in treating patients with non-small cell lung cancer (NSCLC): chemotherapy followed by concurrent chemoradiotherapy (CT-CCRT) and sequential postoperative radiotherapy (PORT) followed by postoperative chemotherapy (POCT). We aimed to compare the clinical outcomes between the two adjuvant protocols. MATERIALS AND METHODS: From March 1997 to October 2012, 68 patients were treated with CT-CCRT (n = 25) and sequential PORT followed by POCT (RT-CT; n = 43)...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730800/gold-nanoparticles-enhance-anti-tumor-effect-of-radiotherapy-to-hypoxic-tumor
#10
Mi Sun Kim, Eun-Jung Lee, Jae-Won Kim, Ui Seok Chung, Won-Gun Koh, Ki Chang Keum, Woong Sub Koom
PURPOSE: Hypoxia can impair the therapeutic efficacy of radiotherapy (RT). Therefore, a new strategy is necessary for enhancing the response to RT. In this study, we investigated whether the combination of nanoparticles and RT is effective in eliminating the radioresistance of hypoxic tumors. MATERIALS AND METHODS: Gold nanoparticles (GNPs) consisting of a silica core with a gold shell were used. CT26 colon cancer mouse model was developed to study whether the combination of RT and GNPs reduced hypoxia-induced radioresistance...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27609109/immunomodulatory-effect-of-captopril-and-local-irradiation-on-myeloid-derived-suppressor-cells
#11
Won Kyung Cho, Sung-Won Shin, Shin-Yeong Kim, Chang-Won Hong, Changhoon Choi, Won Park, Jae Myoung Noh
PURPOSE: This study is to investigate the effect of captopril when combined with irradiation. MATERIALS AND METHODS: 4T1 (mouse mammary carcinoma) cells were injected in the right hind leg of Balb/c mice. Mice were randomized to four groups; control (group 1), captopril-treated (group 2), irradiated (group 3), irradiated and captopril-treated concurrently (group 4). Captopril was administered by intraperitoneal injection (10 mg/kg) daily and irradiation was delivered on the tumor-bearing leg for 15 Gy in 3 fractions...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27592515/organ-preservation-with-neoadjuvant-chemoradiation-in-patients-with-orbit-invasive-sinonasal-cancer-otherwise-requiring-exenteration
#12
Mark J Amsbaugh, Mehran Yusuf, Craig Silverman, Jeffrey Bumpous, Cesar A Perez, Keven Potts, Paul Tennant, Rebecca Redman, Neal Dunlap
PURPOSE: We sought to determine if organ preservation (OP) with neoadjuvant chemoradiation (CRT) was feasible in patients with sinonasal cancer determined to require exenteration. MATERIALS AND METHODS: Twenty patients were determined to require exenteration for definitive treatment from 2005 to 2014. Fourteen patients underwent OP and 6 patients received exenteration with adjuvant CRT. Exenteration free survival (EFS), locoregional control (LRC), progression-free survival (PFS), and overall survival (OS) were estimated...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27592514/correlation-between-tumor-regression-grade-and-rectal-volume-in-neoadjuvant-concurrent-chemoradiotherapy-for-rectal-cancer
#13
Hong Seok Lee, Doo Ho Choi, Hee Chul Park, Won Park, Jeong Il Yu, Kwangzoo Chung
PURPOSE: To determine whether large rectal volume on planning computed tomography (CT) results in lower tumor regression grade (TRG) after neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer patients. MATERIALS AND METHODS: We reviewed medical records of 113 patients treated with surgery following neoadjuvant CCRT for rectal cancer between January and December 2012. Rectal volume was contoured on axial images in which gross tumor volume was included...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27545294/the-response-of-thrombosis-in-the-portal-vein-or-hepatic-vein-in-hepatocellular-carcinoma-to-radiation-therapy
#14
Bong Kyung Bae, Jae-Chul Kim
PURPOSE: The purpose of current study is to evaluate the response of the patients with portal vein thrombosis (PVT) or hepatic vein thrombosis (HVT) in hepatocellular carcinoma (HCC) treated with three-dimensional conformal radiation therapy (3D-CRT). In addition, survival of patients and potential prognostic factors of the survival was evaluated. MATERIALS AND METHODS: Forty-seven patients with PVT or HVT in HCC, referred to our department for radiotherapy, were retrospectively reviewed...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27306777/hypofractionated-stereotactic-body-radiotherapy-in-low-and-intermediate-risk-prostate-carcinoma
#15
Hun Jung Kim, Jeong Hoon Phak, Woo Chul Kim
Purpose: Stereotactic body radiotherapy (SBRT) takes advantage of low α/β ratio of prostate cancer to deliver a large dose in few fractions. We examined clinical outcomes of SBRT using CyberKnife for the treatment of low- and intermediate-risk prostate cancer. Materials and Methods: This study was based on a retrospective analysis of the 33 patients treated with SBRT using CyberKnife for localized prostate cancer (27.3% in low-risk and 72.7% in intermediate-risk)...
June 17, 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27381419/the-clinical-utilization-of-radiation-therapy-in-korea-between-2009-and-2013
#16
Jin-Kyu Kang, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Hyun Jin Song
PURPOSE: The purpose of this study was to estimate the clinical utilization of radiation therapy (RT) in Korea between 2009 and 2013. MATERIALS AND METHODS: We analyzed open claims data from the Health Insurance Review and Assessment Service. The subjects were patients who had diagnostic codes C00-C97 or D00-D48 according to the 10th revision of the International Classification of Diseases, with procedure codes indicating RT treatment. RESULTS: The total number of patients who received RT in 2009, 2010, 2011, 2012, and 2013 were 45,571, 49,593, 54,671, 59,172, and 61,485, respectively...
June 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27306779/dosimetric-comparison-of-axilla-and-groin-radiotherapy-techniques-for-high-risk-and-locally-advanced-skin-cancer
#17
Malcolm D Mattes, Ying Zhou, Sean L Berry, Christopher A Barker
PURPOSE: Radiation therapy targeting axilla and groin lymph nodes improves regional disease control in locally advanced and high-risk skin cancers. However, trials generally used conventional two-dimensional radiotherapy (2D-RT), contributing towards relatively high rates of side effects from treatment. The goal of this study is to determine if three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), or volumetric-modulated arc therapy (VMAT) may improve radiation delivery to the target while avoiding organs at risk in the clinical context of skin cancer regional nodal irradiation...
June 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27306778/art-therapy-using-famous-painting-appreciation-maintains-fatigue-levels-during-radiotherapy-in-cancer-patients
#18
Woong Sub Koom, Mi Yeon Choi, Jeongshim Lee, Eun Jung Park, Ju Hye Kim, Sun-Hyun Kim, Yong Bae Kim
PURPOSE: The purpose of this study was to evaluate the efficacy of art therapy to control fatigue in cancer patients during course of radiotherapy and its impact on quality of life (QoL). MATERIALS AND METHODS: Fifty cancer patients receiving radiotherapy received weekly art therapy sessions using famous painting appreciation. Fatigue and QoL were assessed using the Brief Fatigue Inventory (BFI) Scale and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) at baseline before starting radiotherapy, every week for 4 weeks during radiotherapy, and at the end of radiotherapy...
June 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27306776/predictors-of-pathologic-complete-response-after-preoperative-concurrent-chemoradiotherapy-of-rectal-cancer-a-single-center-experience
#19
Euncheol Choi, Jin Hee Kim, Ok Bae Kim, Mi Young Kim, Young Ki Oh, Sung Gyu Baek
PURPOSE: To identify possible predictors of pathologic complete response (pCR) of rectal cancer after preoperative concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: We conducted a retrospective review of 53 patients with rectal cancer who underwent preoperative CCRT followed by radical surgery at a single center between January 2007 and December 2012. The median radiotherapy dose to the pelvis was 54.0 Gy (range, 45.0 to 63.0 Gy). Five-fluorouracil-based chemotherapy was administered via continuous infusion with leucovorin...
June 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27306775/long-term-outcomes-of-surgery-and-radiotherapy-for-secreting-and-non-secreting-pituitary-adenoma
#20
Mi Young Kim, Jin Hee Kim, Young Kee Oh, El Kim
PURPOSE: To investigate treatment outcome and long term complication after surgery and radiotherapy (RT) for pituitary adenoma. MATERIALS AND METHODS: From 1990 to 2009, 73 patients with surgery and RT for pituitary adenoma were analyzed in this study. Median age was 51 years (range, 25 to 71 years). Median tumor size was 3 cm (range, 1 to 5 cm) with suprasellar (n = 21), cavernous sinus extension (n = 14) or both (n = 5). Hormone secreting tumor was diagnosed in 29 patients; 16 patients with prolactin, 12 patients with growth hormone, and 1 patient with adrenocorticotrophic hormone...
June 2016: Radiation Oncology Journal
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