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Radiation Oncology Journal

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https://www.readbyqxmd.com/read/28395504/influence-of-jaw-tracking-in-intensity-modulated-and-volumetric-modulated-arc-radiotherapy-for-head-and-neck-cancers-a-dosimetric-study
#1
Karthick Raj Mani, Sagar Upadhayay, K J Maria Das
PURPOSE: To Study the dosimetric advantage of the Jaw tracking technique in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for Head and Neck Cancers. MATERIALS AND METHODS: We retrospectively selected 10 previously treated head and neck cancer patients stage (T1/T2, N1, M0) in this study. All the patients were planned for IMRT and VMAT with simultaneous integrated boost technique. IMRT and VMAT plans were performed with jaw tracking (JT) and with static jaw (SJ) technique by keeping the same constraints and priorities for a particular patient...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28395503/radiotherapy-for-locally-recurrent-rectal-cancer-treated-with-surgery-alone-as-the-initial-treatment
#2
Hidekazu Tanaka, Takahiro Yamaguchi, Kae Hachiya, Sunaho Okada, Masashi Kitahara, Katsuya Matsuyama, Masayuki Matsuo
PURPOSE: Although the technical developments of radiotherapy have been remarkable, there are currently few reports on the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as initial treatment in this three-dimensional conformal radiotherapy era. Thus, we retrospectively evaluated the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as the initial treatment. MATERIALS AND METHODS: Thirty-two patients who underwent radiotherapy were enrolled in this study...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28395502/reirradiation-of-head-and-neck-cancer-in-the-era-of-intensity-modulated-radiotherapy-patient-selection-practical-aspects-and-current-evidence
#3
REVIEW
Yeon Sil Kim
Locoregional failure is the most frequent pattern of failure in locally advanced head and neck cancer patients and it leads to death in most of the patients. Second primary tumors occurring in the other head and neck region reach up to almost 40% of long-term survivors. Recommended and preferred retreatment option in operable patients is salvage surgical resection, reporting a 5-year overall survival of up to 40%. However, because of tumor location, extent, and underlying comorbidities, salvage surgery is often limited and compromised by incomplete resection...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28395501/multidisciplinary-team-approach-for-the-management-of-patients-with-locally-advanced-non-small-cell-lung-cancer-searching-the-evidence-to-guide-the-decision
#4
REVIEW
In-Jae Oh, Sung-Ja Ahn
Locally advanced non-small cell lung cancer (LA-NSCLC) is composed of heterogeneous subgroups that require a multidisciplinary team approach in order to ensure optimal therapy for each patient. Since 2010, the National Comprehensive Cancer Network has recommended chemoradiation therapy (CRT) for bulky mediastinal disease and surgical combination for those patients with single-station N2 involvement who respond to neoadjuvant therapy. According to lung cancer tumor boards, thoracic surgeons make a decision on the resectability of the tumor, if it is determined to be unresectable, concurrent CRT (CCRT) is considered the next choice...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28292006/radiotherapy-in-prostate-cancer-treatment-results-of-the-patterns-of-care-study-in-korea
#5
Ah Ram Chang, Won Park
PURPOSE: The purpose of this study was to describe treatment patterns of radiotherapy (RT) for prostate cancer in Korea. MATERIALS AND METHODS: A questionnaire about radiation treatment technique and principles in 2013 was sent to 83 radiation oncologists and data from 57 hospitals were collected analyzed to find patterns of RT for prostate cancer patients in Korea. RESULTS: The number of patients with prostate cancer treated with definitive RT ranged from 1 to 72 per hospital in 2013...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28278561/the-role-of-surgical-clips-in-the-evaluation-of-interfractional-uncertainty-for-treatment-of-hepatobiliary-and-pancreatic-cancer-with-postoperative-radiotherapy
#6
Jin Suk Bae, Dong Hyun Kim, Won Taek Kim, Yong Ho Kim, Dahl Park, Yong Kan Ki
PURPOSE: To evaluate the utility of implanted surgical clips for detecting interfractional errors in the treatment of hepatobiliary and pancreatic cancer with postoperative radiotherapy (PORT). METHODS AND MATERIALS: Twenty patients had been treated with PORT for locally advanced hepatobiliary or pancreatic cancer, from November 2014 to April 2016. Patients underwent computed tomography simulation and were treated in expiratory breathing phase. During treatment, orthogonal kilovoltage (kV) imaging was taken twice a week, and isocenter shifts were made to match bony anatomy...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28183161/radiotherapy-for-gastric-mucosa-associated-lymphoid-tissue-lymphoma-dosimetric-comparison-and-risk-assessment-of-solid-secondary-cancer
#7
Sun Hyun Bae, Dong Wook Kim, Mi-Sook Kim, Myung-Hee Shin, Hee Chul Park, Do Hoon Lim
PURPOSE: To determine the optimal radiotherapy technique for gastric mucosa-associated lymphoid tissue lymphoma (MALToma), we compared the dosimetric parameters and the risk of solid secondary cancer from scattered doses among anterior-posterior/posterior-anterior parallel-opposed fields (AP/PA), anterior, posterior, right, and left lateral fields (4_field), 3-dimensional conformal radiotherapy (3D-CRT) using noncoplanar beams, and intensity-modulated radiotherapy composed of 7 coplanar beams (IMRT_co) and 7 coplanar and noncoplanar beams (IMRT_non)...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28183160/long-term-outcomes-after-salvage-radiotherapy-for-postoperative-locoregionally-recurrent-non-small-cell-lung-cancer
#8
Eunji Kim, Changhoon Song, Mi Young Kim, Jae-Sung Kim
PURPOSE: The outcomes and toxicities of locoregionally recurrent non-small-cell lung cancer (NSCLC) patients treated with curative radiotherapy were evaluated in the modern era. MATERIALS AND METHODS: Fifty-seven patients receiving radical radiotherapy for locoregionally recurrent NSCLC without distant metastasis after surgery from 2004 to 2014 were reviewed. Forty-two patients were treated with concurrent chemoradiotherapy (CCRT), and 15 patients with radiotherapy alone...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28183159/a-novel-schedule-of-accelerated-partial-breast-radiation-using-intensity-modulated-radiation-therapy-in-elderly-patients-survival-and-toxicity-analysis-of-a-prospective-clinical-trial
#9
Mutlay Sayan, Karen Wilson, Carl Nelson, Havaleh Gagne, Deborah Rubin, Ruth Heimann
PURPOSE: Several accelerated partial breast radiation (APBR) techniques have been investigated in patients with early-stage breast cancer (BC); however, the optimal treatment delivery techniques remain unclear. We evaluated the feasibility and toxicity of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I BC, using a novel fractionation schedule. MATERIALS AND METHODS: Forty-two patients aged ≥65 years, with stage I BC who underwent breast conserving surgery were enrolled in a phase I/II study evaluating APBR using IMRT...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27997788/adverse-effect-of-excess-body-weight-on-survival-in-cervical-cancer-patients-after-surgery-and-radiotherapy
#10
Yunseon Choi, Ki Jung Ahn, Sung Kwang Park, Heunglae Cho, Ji Young Lee
PURPOSE: This study aimed to assess the effects of body mass index (BMI) on survival in cervical cancer patients who had undergone surgery and radiotherapy (RT). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 70 cervical cancer patients who underwent surgery and RT from 2007 to 2012. Among them, 40 patients (57.1%) had pelvic lymph node metastases at the time of diagnosis. Sixty-seven patients (95.7%) had received chemotherapy. All patients had undergone surgery and postoperative RT...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27927011/clinical-outcomes-in-patients-treated-with-radiotherapy-after-surgery-for-cervical-cancer
#11
Kyungmi Yang, Won Park, Seung Jae Huh, Duk-Soo Bae, Byoung-Gie Kim, Jeong-Won Lee
PURPOSE: The purpose of this study was to analyze clinical outcomes from cervical cancer and stratify patients into risk groups for prognostic factors for early-stage disease. MATERIALS AND METHODS: We retrospectively reviewed patients with stage IB or IIA cervical cancer treated with adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) following primary surgery at Samsung Medical Center from 2001 to 2011. Adjuvant RT was added for patients with intermediate-risk factors, and adjuvant CCRT was performed on high-risk patients after surgery...
March 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030901/radiotherapy-and-immune-checkpoint-blockades-a-snapshot-in-2016
#12
REVIEW
Taeryool Koo, In Ah Kim
Immune checkpoint blockades including monoclonal antibodies (mAbs) of cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and programmed death-ligand 1 (PD-L1) have been emerged as a promising anticancer therapy. Several immune checkpoint blockades have been approved by US Food and Drug Administration (FDA), and have shown notable success in clinical trials for patients with advanced melanoma and non-small cell lung cancer. Radiotherapy is a promising combination partner of immune checkpoint blockades due to its potent pro-immune effect...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030900/tumor-hypoxia-and-reoxygenation-the-yin-and-yang-for-radiotherapy
#13
REVIEW
Beom-Ju Hong, Jeongwoo Kim, Hoibin Jeong, Seoyeon Bok, Young-Eun Kim, G-One Ahn
Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major contributing factor for failures of anticancer therapies. Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized. In this review, we will highlight some of the past attempts to overcome tumor hypoxia including hypoxic radiosensitizers and hypoxia-selective cytotoxin. Although they were (still are) a very clever idea, they lacked clinical efficacy largely because of 'reoxygenation' phenomenon occurring in the conventional low dose hyperfractionation radiotherapy prevented proper activation of these compounds...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030899/analysis-of-treatment-outcomes-for-primary-tonsillar-lymphoma
#14
Yun Hee Lee, Seok Goo Cho, Seung Eun Jung, Sung Hoon Kim, Joo Hyun O, Gyeong Sin Park, Suk Woo Yang, In Seok Lee, Chin Kook Rhee, Byung Ock Choi
PURPOSE: Although each Waldeyer's ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT). MATERIALS AND METHODS: Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age, sex, and histology, amongst other factors, were reviewed...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030898/early-hypopharyngeal-cancer-treated-with-different-therapeutic-approaches-a-single-institution-cohort-analysis
#15
Nalee Kim, Jeongshim Lee, Kyung Hwan Kim, Jong Won Park, Chang Geol Lee, Ki Chang Keum
PURPOSE: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment. MATERIALS AND METHODS: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January 1992 and March 2014 were reviewed. Patients received definitive radiotherapy (RT) (R group, n = 10), surgery only (S group, n = 19), or postoperative RT (PORT group, n = 7)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27951625/dosimetric-comparison-of-intensity-modulated-radiotherapy-imrt-and-volumetric-modulated-arc-therapy-vmat-in-total-scalp-irradiation-a-single-institutional-experience
#16
Christian Ostheimer, Patrick Hübsch, Martin Janich, Reinhard Gerlach, Dirk Vordermark
PURPOSE: Total scalp irradiation (TSI) is a rare but challenging indication. We previously reported that non-coplanar intensity-modulated radiotherapy (IMRT) was superior to coplanar IMRT in organ-at-risk (OAR) protection and target dose distribution. This consecutive treatment planning study compared IMRT with volumetric-modulated arc therapy (VMAT). MATERIALS AND METHODS: A retrospective treatment plan databank search was performed and 5 patient cases were randomly selected...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27951624/postoperative-radiotherapy-appeared-to-improve-the-disease-free-survival-rate-of-patients-with-extrahepatic-bile-duct-cancer-at-high-risk-of-loco-regional-recurrence
#17
Mi Young Kim, Jin Hee Kim, Yonghoon Kim, Sang Jun Byun
PURPOSE: To investigate the outcomes of postoperative radiotherapy (RT), in patients with extrahepatic bile duct (EHBD) cancer by comparing the survival rate between patients undergoing surgery alone or surgery plus postoperative RT, and to identify the prognostic factors affecting survival. MATERIALS AND METHODS: Between 2000 and 2013, 52 patients with EHBD cancer underwent surgical resection. Of these, 33 patients did not receive postoperative RT (group I), and 19 patients did (group II)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27927012/nodal-tumor-response-according-to-the-count-of-peripheral-blood-lymphocyte-subpopulations-during-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#18
Jaesung Heo, Young-Taek Oh, O Kyu Noh, Mison Chun, Jun-Eun Park, Sung-Ran Cho
PURPOSE: The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. MATERIALS AND METHODS: From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27703126/treatment-outcomes-after-adjuvant-radiotherapy-following-surgery-for-patients-with-stage-i-endometrial-cancer
#19
Jiyoung Kim, Kyung-Ja Lee, Kyung-Ran Park, Boram Ha, Yi-Jun Kim, Wonguen Jung, Rena Lee, Seung Cheol Kim, Hye Sung Moon, Woong Ju, Yun Hwan Kim, Jihae Lee
PURPOSE: The purpose of this study is to evaluate the treatment outcomes of adjuvant radiotherapy using vaginal brachytherapy (VB) with a lower dose per fraction and/or external beam radiotherapy (EBRT) following surgery for patients with stage I endometrial carcinoma. MATERIALS AND METHODS: The subjects were 43 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer who underwent adjuvant radiotherapy following surgery between March 2000 and April 2014...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27609110/the-impact-of-radiotherapy-on-clinical-outcomes-in-parameningeal-rhabdomyosarcoma
#20
Yunseon Choi, Do Hoon Lim
PURPOSE: Radiotherapy (RT) is considered a mainstay of treatment in parameningeal rhabdomyosarcoma (PM-RMS). We aim to determine the treatment outcomes and prognostic factors for PM-RMS patients who treated with RT. In addition, we tried to evaluate the adequate dose and timing of RT. MATERIALS AND METHODS: Twenty-two patients with PM-RMS from 1995 to 2013 were evaluated. Seven patients had intracranial extension (ICE) and 17 patients had skull base bony erosion (SBBE)...
December 2016: Radiation Oncology Journal
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