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Radiation Oncology Journal

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https://www.readbyqxmd.com/read/27997788/adverse-effect-of-excess-body-weight-on-survival-in-cervical-cancer-patients-after-surgery-and-radiotherapy
#1
Yunseon Choi, Ki Jung Ahn, Sung Kwang Park, Heunglae Cho, Ji Young Lee
Purpose: This study aimed to assess the effects of body mass index (BMI) on survival in cervical cancer patients who had undergone surgery and radiotherapy (RT). Materials and Methods: We retrospectively reviewed the medical records of 70 cervical cancer patients who underwent surgery and RT from 2007 to 2012. Among them, 40 patients (57.1%) had pelvic lymph node metastases at the time of diagnosis. Sixty-seven patients (95.7%) had received chemotherapy. All patients had undergone surgery and postoperative RT...
December 22, 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27927011/clinical-outcomes-in-patients-treated-with-radiotherapy-after-surgery-for-cervical-cancer
#2
Kyungmi Yang, Won Park, Seung Jae Huh, Duk-Soo Bae, Byoung-Gie Kim, Jeong-Won Lee
Purpose: The purpose of this study was to analyze clinical outcomes from cervical cancer and stratify patients into risk groups for prognostic factors for early-stage disease. Materials and Methods: We retrospectively reviewed patients with stage IB or IIA cervical cancer treated with adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) following primary surgery at Samsung Medical Center from 2001 to 2011. Adjuvant RT was added for patients with intermediate-risk factors, and adjuvant CCRT was performed on high-risk patients after surgery...
December 12, 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030901/radiotherapy-and-immune-checkpoint-blockades-a-snapshot-in-2016
#3
REVIEW
Taeryool Koo, In Ah Kim
Immune checkpoint blockades including monoclonal antibodies (mAbs) of cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and programmed death-ligand 1 (PD-L1) have been emerged as a promising anticancer therapy. Several immune checkpoint blockades have been approved by US Food and Drug Administration (FDA), and have shown notable success in clinical trials for patients with advanced melanoma and non-small cell lung cancer. Radiotherapy is a promising combination partner of immune checkpoint blockades due to its potent pro-immune effect...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030900/tumor-hypoxia-and-reoxygenation-the-yin-and-yang-for-radiotherapy
#4
REVIEW
Beom-Ju Hong, Jeongwoo Kim, Hoibin Jeong, Seoyeon Bok, Young-Eun Kim, G-One Ahn
Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major contributing factor for failures of anticancer therapies. Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized. In this review, we will highlight some of the past attempts to overcome tumor hypoxia including hypoxic radiosensitizers and hypoxia-selective cytotoxin. Although they were (still are) a very clever idea, they lacked clinical efficacy largely because of 'reoxygenation' phenomenon occurring in the conventional low dose hyperfractionation radiotherapy prevented proper activation of these compounds...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030899/analysis-of-treatment-outcomes-for-primary-tonsillar-lymphoma
#5
Yun Hee Lee, Seok Goo Cho, Seung Eun Jung, Sung Hoon Kim, Joo Hyun O, Gyeong Sin Park, Suk Woo Yang, In Seok Lee, Chin Kook Rhee, Byung Ock Choi
PURPOSE: Although each Waldeyer's ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT). MATERIALS AND METHODS: Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age, sex, and histology, amongst other factors, were reviewed...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28030898/early-hypopharyngeal-cancer-treated-with-different-therapeutic-approaches-a-single-institution-cohort-analysis
#6
Nalee Kim, Jeongshim Lee, Kyung Hwan Kim, Jong Won Park, Chang Geol Lee, Ki Chang Keum
PURPOSE: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment. MATERIALS AND METHODS: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January 1992 and March 2014 were reviewed. Patients received definitive radiotherapy (RT) (R group, n = 10), surgery only (S group, n = 19), or postoperative RT (PORT group, n = 7)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27951625/dosimetric-comparison-of-intensity-modulated-radiotherapy-imrt-and-volumetric-modulated-arc-therapy-vmat-in-total-scalp-irradiation-a-single-institutional-experience
#7
Christian Ostheimer, Patrick Hübsch, Martin Janich, Reinhard Gerlach, Dirk Vordermark
PURPOSE: Total scalp irradiation (TSI) is a rare but challenging indication. We previously reported that non-coplanar intensity-modulated radiotherapy (IMRT) was superior to coplanar IMRT in organ-at-risk (OAR) protection and target dose distribution. This consecutive treatment planning study compared IMRT with volumetric-modulated arc therapy (VMAT). MATERIALS AND METHODS: A retrospective treatment plan databank search was performed and 5 patient cases were randomly selected...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27951624/postoperative-radiotherapy-appeared-to-improve-the-disease-free-survival-rate-of-patients-with-extrahepatic-bile-duct-cancer-at-high-risk-of-loco-regional-recurrence
#8
Mi Young Kim, Jin Hee Kim, Yonghoon Kim, Sang Jun Byun
PURPOSE: To investigate the outcomes of postoperative radiotherapy (RT), in patients with extrahepatic bile duct (EHBD) cancer by comparing the survival rate between patients undergoing surgery alone or surgery plus postoperative RT, and to identify the prognostic factors affecting survival. MATERIALS AND METHODS: Between 2000 and 2013, 52 patients with EHBD cancer underwent surgical resection. Of these, 33 patients did not receive postoperative RT (group I), and 19 patients did (group II)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27927012/nodal-tumor-response-according-to-the-count-of-peripheral-blood-lymphocyte-subpopulations-during-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#9
Jaesung Heo, Young-Taek Oh, O Kyu Noh, Mison Chun, Jun-Eun Park, Sung-Ran Cho
PURPOSE: The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. MATERIALS AND METHODS: From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27703126/treatment-outcomes-after-adjuvant-radiotherapy-following-surgery-for-patients-with-stage-i-endometrial-cancer
#10
Jiyoung Kim, Kyung-Ja Lee, Kyung-Ran Park, Boram Ha, Yi-Jun Kim, Wonguen Jung, Rena Lee, Seung Cheol Kim, Hye Sung Moon, Woong Ju, Yun Hwan Kim, Jihae Lee
PURPOSE: The purpose of this study is to evaluate the treatment outcomes of adjuvant radiotherapy using vaginal brachytherapy (VB) with a lower dose per fraction and/or external beam radiotherapy (EBRT) following surgery for patients with stage I endometrial carcinoma. MATERIALS AND METHODS: The subjects were 43 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer who underwent adjuvant radiotherapy following surgery between March 2000 and April 2014...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27609110/the-impact-of-radiotherapy-on-clinical-outcomes-in-parameningeal-rhabdomyosarcoma
#11
Yunseon Choi, Do Hoon Lim
PURPOSE: Radiotherapy (RT) is considered a mainstay of treatment in parameningeal rhabdomyosarcoma (PM-RMS). We aim to determine the treatment outcomes and prognostic factors for PM-RMS patients who treated with RT. In addition, we tried to evaluate the adequate dose and timing of RT. MATERIALS AND METHODS: Twenty-two patients with PM-RMS from 1995 to 2013 were evaluated. Seven patients had intracranial extension (ICE) and 17 patients had skull base bony erosion (SBBE)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27306777/hypofractionated-stereotactic-body-radiotherapy-in-low-and-intermediate-risk-prostate-carcinoma
#12
Hun Jung Kim, Jeong Hoon Phak, Woo Chul Kim
PURPOSE: Stereotactic body radiotherapy (SBRT) takes advantage of low α/β ratio of prostate cancer to deliver a large dose in few fractions. We examined clinical outcomes of SBRT using CyberKnife for the treatment of low- and intermediate-risk prostate cancer. MATERIALS AND METHODS: This study was based on a retrospective analysis of the 33 patients treated with SBRT using CyberKnife for localized prostate cancer (27.3% in low-risk and 72.7% in intermediate-risk)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730805/application-of-radiotherapy-for-hepatocellular-carcinoma-in-current-clinical-practice-guidelines
#13
REVIEW
Chai Hong Rim, Jinsil Seong
In oncologic practice, treatment guidelines provide appropriate treatment strategies based on evidence. Currently, many guidelines are used, including those of the European Association for the Study of the Liver and European Organization for Research and Treatment of Cancer (EASL-EORTC), National Comprehensive Cancer Network (NCCN), Asia-Pacific Primary Liver Cancer Expert (APPLE), and Korean Liver Cancer Study Group and National Cancer Centre (KLCSG-NCC). Although radiotherapy is commonly used in clinical practice, some guidelines do not accept it as a standard treatment modality...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730804/preoperative-chemoradiotherapy-followed-by-local-excision-in-clinical-t2n0-rectal-cancer
#14
Young Seob Shin, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Tae Won Kim, Heung Moon Chang, Jin-Hong Park, Seung Do Ahn, Sang-Wook Lee, Eun Kyung Choi, Jin Cheon Kim, Jong Hoon Kim
PURPOSE: To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients. MATERIALS AND METHODS: Patients who received PCRT and LE because of clinical T2 rectal cancer within 7 cm from anal verge between January 2006 and June 2014 were retrospectively analyzed. LE was performed in case of a good clinical response after PCRT. Patients' characteristics, treatment record, tumor recurrence, and treatment-related complications were reviewed at a median follow-up of 49 months...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730803/radiation-therapy-for-gastric-mucosa-associated-lymphoid-tissue-lymphoma-dose-volumetric-analysis-and-its-clinical-implications
#15
Hyeon Woo Lim, Tae Hyun Kim, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Soo Jeong Cho, Hyeon Seok Eom, Sung Ho Moon, Dae Yong Kim
PURPOSE: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness of involved field RT with moderate-dose and to evaluate the benefit of 3D-CRT comparing with 2D-RT. MATERIALS AND METHODS: Between July 2003 and March 2015, 33 patients with stage IE and IIE gastric MALT lymphoma received RT were analyzed...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730802/retroperitoneal-liposarcoma-the-role-of-adjuvant-radiation-therapy-and-the-prognostic-factors
#16
Hong Seok Lee, Jeong Il Yu, Do Hoon Lim, Sung Joo Kim
PURPOSE: To evaluate the benefit of adjuvant radiation therapy (RT) for retroperitoneal liposarcoma (RPLS) following gross tumor removal. MATERIALS AND METHODS: We reviewed 77 patients with primary RPLS surgically treated between January 2000 and December 2013. Cases with gross residual disease were excluded. Tumor grade was evaluated according to the French Federation of Cancer Centers Sarcoma Group (FNCLCC) system. Adjuvant RT was delivered to 32 patients (42%) using external beam RT alone...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730801/comparison-of-concurrent-chemoradiotherapy-versus-sequential-radiochemotherapy-in-patients-with-completely-resected-non-small-cell-lung-cancer
#17
Hwan-Ik Kim, O Kyu Noh, Young-Taek Oh, Mison Chun, Sang-Won Kim, Oyeon Cho, Jaesung Heo
PURPOSE: Our institution has implemented two different adjuvant protocols in treating patients with non-small cell lung cancer (NSCLC): chemotherapy followed by concurrent chemoradiotherapy (CT-CCRT) and sequential postoperative radiotherapy (PORT) followed by postoperative chemotherapy (POCT). We aimed to compare the clinical outcomes between the two adjuvant protocols. MATERIALS AND METHODS: From March 1997 to October 2012, 68 patients were treated with CT-CCRT (n = 25) and sequential PORT followed by POCT (RT-CT; n = 43)...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27730800/gold-nanoparticles-enhance-anti-tumor-effect-of-radiotherapy-to-hypoxic-tumor
#18
Mi Sun Kim, Eun-Jung Lee, Jae-Won Kim, Ui Seok Chung, Won-Gun Koh, Ki Chang Keum, Woong Sub Koom
PURPOSE: Hypoxia can impair the therapeutic efficacy of radiotherapy (RT). Therefore, a new strategy is necessary for enhancing the response to RT. In this study, we investigated whether the combination of nanoparticles and RT is effective in eliminating the radioresistance of hypoxic tumors. MATERIALS AND METHODS: Gold nanoparticles (GNPs) consisting of a silica core with a gold shell were used. CT26 colon cancer mouse model was developed to study whether the combination of RT and GNPs reduced hypoxia-induced radioresistance...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27609109/immunomodulatory-effect-of-captopril-and-local-irradiation-on-myeloid-derived-suppressor-cells
#19
Won Kyung Cho, Sung-Won Shin, Shin-Yeong Kim, Chang-Won Hong, Changhoon Choi, Won Park, Jae Myoung Noh
PURPOSE: This study is to investigate the effect of captopril when combined with irradiation. MATERIALS AND METHODS: 4T1 (mouse mammary carcinoma) cells were injected in the right hind leg of Balb/c mice. Mice were randomized to four groups; control (group 1), captopril-treated (group 2), irradiated (group 3), irradiated and captopril-treated concurrently (group 4). Captopril was administered by intraperitoneal injection (10 mg/kg) daily and irradiation was delivered on the tumor-bearing leg for 15 Gy in 3 fractions...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27592515/organ-preservation-with-neoadjuvant-chemoradiation-in-patients-with-orbit-invasive-sinonasal-cancer-otherwise-requiring-exenteration
#20
Mark J Amsbaugh, Mehran Yusuf, Craig Silverman, Jeffrey Bumpous, Cesar A Perez, Keven Potts, Paul Tennant, Rebecca Redman, Neal Dunlap
PURPOSE: We sought to determine if organ preservation (OP) with neoadjuvant chemoradiation (CRT) was feasible in patients with sinonasal cancer determined to require exenteration. MATERIALS AND METHODS: Twenty patients were determined to require exenteration for definitive treatment from 2005 to 2014. Fourteen patients underwent OP and 6 patients received exenteration with adjuvant CRT. Exenteration free survival (EFS), locoregional control (LRC), progression-free survival (PFS), and overall survival (OS) were estimated...
September 2016: Radiation Oncology Journal
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