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Radiation Oncology Journal

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https://www.readbyqxmd.com/read/29983037/correction-intensity-modulated-radiation-therapy-a-review-with-a-physics-perspective
#1
Byungchul Cho
No abstract text is available yet for this article.
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983036/clinical-outcomes-and-prognostic-factors-in-patients-with-mycosis-fungoides-who-underwent-radiation-therapy-in-a-single-institution
#2
Bum-Sup Jang, Eunji Kim, Il Han Kim, Hyun-Cheol Kang, Sung-Joon Ye
PURPOSE: We aimed to evaluate clinical outcomes including progression-free survival (PFS), overall survival (OS), partial response, and complete response in patients who underwent radiation therapy (RT) for mycosis fungoides (MF). Also, we sought to find prognostic factors for clinical outcomes. Materials and. METHODS: Total 19 patients confirmed with MF between 1999-2015 were retrospectively reviewed. Clinical and treatment characteristics, clinical outcomes, and and toxicities were analyzed...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983035/adjuvant-external-beam-radiation-and-brachytherapy-for-vaginal-resection-margin-positive-cervical-cancer
#3
Donghyun Kim, Yongkan Ki, Wontaek Kim, Dahl Park, Joohye Lee, Jayoung Lee, Hosang Jeon, Jiho Nam
PURPOSE: To evaluate the treatment outcomes of adjuvant external beam radiation therapy (EBRT) and vaginal brachytherapy (VB) following radical hysterectomy in cervical cancer patients with involved vaginal resection margin (VRM). Materials and. METHODS: We retrospectively reviewed the medical records of 21 patients treated with postoperative EBRT and VB for positive VRM FIGO stage IB-IIA cervical cancer between 2003 and 2015. Concurrent platinum-based chemotherapy was administered to all patients...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983034/external-validation-of-ibtr-2-0-nomogram-for-prediction-of-ipsilateral-breast-tumor-recurrence
#4
Byung Min Lee, Jee Suk Chang, Young Up Cho, Seho Park, Hyung Seok Park, Jee Ye Kim, Joo Hyuk Sohn, Gun Min Kim, Ja Seung Koo, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
PURPOSE: IBTR! 2.0 nomogram is web-based nomogram that predicts ipsilateral breast tumor recurrence (IBTR). We aimed to validate the IBTR! 2.0 using an external data set. Materials and. METHODS: The cohort consisted of 2,206 patients, who received breast conserving surgery and radiation therapy from 1992 to 2012 at our institution, where wide surgical excision is been routinely performed. Discrimination and calibration were used for assessing model performance. Patients with predicted 10-year IBTR risk based on an IBTR! 2...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983033/is-higher-dose-always-the-right-answer-in-stereotactic-body-radiation-therapy-for-small-hepatocellular-carcinoma
#5
Kyung Hwa Lee, Jeong Il Yu, Hee Chul Park, Su Yeon Park, Jung Suk Shin, Eun Hyuk Shin, Sungkoo Cho, Sang Hoon Jung, Young Yih Han, Do Hoon Lim
PURPOSE: This study was conducted to compare clinical outcomes and treatment-related toxicities after stereotactic body radiation therapy (SBRT) with two different dose regimens for small hepatocellular carcinomas (HCC) ≤3 cm in size. Materials and. METHODS: We retrospectively reviewed 44 patients with liver-confined HCC treated between 2009 and 2014 with SBRT. Total doses of 45 Gy (n = 10) or 60 Gy (n = 34) in 3 fractions were prescribed to the 95% isodose line covering 95% of the planning target volume...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983032/positional-uncertainties-of-cervical-and-upper-thoracic-spine-in-stereotactic-body-radiotherapy-with-thermoplastic-mask-immobilization
#6
Seung Hyuck Jeon, Jin Ho Kim
PURPOSE: To investigate positional uncertainty and its correlation with clinical parameters in spine stereotactic body radiotherapy (SBRT) using thermoplastic mask (TM) immobilization. Materials and. METHODS: A total of 21 patients who underwent spine SBRT for cervical or upper thoracic spinal lesions were retrospectively analyzed. All patients were treated with image guidance using cone beam computed tomography (CBCT) and 4 degrees-of-freedom (DoF) positional correction...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983031/maximum-diameter-versus-volumetric-assessment-for-the-response-evaluation-of-vestibular-schwannomas-receiving-stereotactic-radiotherapy
#7
Youngmin Choi, Sungmin Kim, Dong-Won Kwak, Hyung-Sik Lee, Myung-Koo Kang, Dong-Kun Lee, Won-Joo Hur
PURPOSE: To explore the feasibility of maximum diameter as a response assessment method for vestibular schwannomas (VS) after stereotactic radiosurgery or fractionated stereotactic radiotherapy (RT), we analyzed the concordance of RT responses between maximum diameters and volumetric measurements. Materials and. METHODS: Forty-two patients receiving curative stereotactic radiosurgery or fractionated stereotactic RT for VS were analyzed retrospectively. Twelve patients were excluded: 4 did not receive follow-up magnetic resonance imaging (MRI) scans and 8 had initial MRI scans with a slice thickness >3 mm...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983030/treatment-outcomes-of-radiotherapy-for-anaplastic-thyroid-cancer
#8
Jong Won Park, Seo Hee Choi, Hong In Yoon, Jeongshim Lee, Tae Hyung Kim, Jun Won Kim, Ik Jae Lee
PURPOSE: Anaplastic thyroid cancer (ATC) is a rare tumor with a lethal clinical course despite aggressive multimodal therapy. Intensity-modulated radiotherapy (IMRT) may achieve a good therapeutic outcome in ATC patients, and the role of IMRT should be assessed. We retrospectively reviewed outcomes for ATC treated with three-dimensional conformal radiotherapy (3D-CRT) or IMRT to determine the optimal treatment option and explore the role of radiotherapy (RT). Materials and. METHODS: Between December 2000 and December 2015, 41 patients with pathologically proven ATC received RT with a sufficient dose of ≥40 Gy...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983029/prognostic-value-of-fdg-pet-ct-during-radiotherapy-in-head-and-neck-cancer-patients
#9
Suzy Kim, Sowon Oh, Jin Soo Kim, Yu Kyeong Kim, Kwang Hyun Kim, Do Hoon Oh, Dong-Han Lee, Woo-Jin Jeong, Young Ho Jung
PURPOSE: To evaluate the prognostic value of 18F-fluorodeoxyglucose positron-emission tomography (FDG PET) with computed tomography (CT) before and during radiotherapy (RT) in patients with head and neck cancer. METHODS: Twenty patients with primary head and neck squamous cell carcinoma were enrolled in this study, of whom 6 had oropharyngeal cancer, 10 had hypopharyngeal cancer, and 4 had laryngeal cancer. Fifteen patients received concurrent cisplatin and 2 received concurrent cetuximab chemotherapy...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29983028/radiation-induced-secondary-malignancies-a-review-article
#10
Chinna Babu Dracham, Abhash Shankar, Renu Madan
Radiation-induced second malignancies (RISM) is one of the important late side effects of radiation therapy and has an impact on optimal treatment decision-making. Many factors contribute to the development of RISM such as age at radiation, dose and volume of irradiated area, type of irradiated organ and tissue, radiation technique and individual and family history of cancer. Exact mechanism of RISM is unknown. But nowadays, it is a growing concern in oncology because of the increased number of cancer survivors and efforts are being made to prevent or decrease the incidence of RISM...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29627970/merkel-cell-carcinoma-in-the-community-setting-a-case-report
#11
Cameron M Callaghan, Rumpa Amornmarn
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin initially believed to arise from the Merkel cells. In the community setting a general radiation oncologist may only encounter this pathology in a handful of cases over the course of their career. Due to the low incidence of this malignancy, few prospective randomized controlled trials have ever been conducted and therefore guidelines are based on relatively lower levels of evidence upon which the clinical recommendations are made. We discuss the case of a female in her 90s presenting with a classic MCC primary lesion, as well as satellite lesions proximal to both the primary and the draining regional lymph nodes with no evidence of nodal involvement...
June 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621873/set-up-errors-in-head-and-neck-cancer-treated-with-imrt-technique-assessed-by-cone-beam-computed-tomography-a-feasible-protocol
#12
Durim Delishaj, Stefano Ursino, Francesco Pasqualetti, Fabrizio Matteucci, Agostino Cristaudo, Carlo Pietro Soatti, Amelia Barcellini, Fabiola Paiar
PURPOSE: To investigate set-up errors, suggest the adequate planning target volume (PTV) margin and image-guided radiotherapy frequency in head and neck (H&N) cancer treated with intensity-modulated radiotherapy (IMRT) assessed by kV cone-beam computed tomography (CBCT). METHODS: We analyzed 360 CBCTs in 60 patients with H&N cancer treated with IMRT. The target delineation was contoured according to ICRU62. PTVs were generated by adding a 3-5 mm margin in all directions to the respective clinical target volumes...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621872/dosimetric-comparison-of-imrt-versus-3dcrt-for-post-mastectomy-chest-wall-irradiation
#13
Kartick Rastogi, Shantanu Sharma, Shivani Gupta, Nikesh Agarwal, Sandeep Bhaskar, Sandeep Jain
PURPOSE: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. MATERIALS AND METHODS: One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters-Dnear-max (D2 ), Dnear-min (D98 ), Dmean , V95 , and V107 -homogeneity index (HI), and conformity index (CI) were compared...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621871/impact-of-radiation-dose-on-concurrent-chemoradiotherapy-for-limited-stage-small-cell-lung-cancer
#14
Junhee Park, Min Kyu Kang
PURPOSE: To evaluate clinical outcomes according to radiation dose in patients with limited-stage small-cell lung cancer (LS-SCLC) treated with concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: From January 2006 to December 2015, 38 patients with LS-SCLC were treated with CCRT with etoposide and cisplatin. Total radiation doses ranged from 45 Gy to 66 Gy (1.8-2 Gy/fraction) and were classified into three groups: 45-54 Gy, 60-63 Gy, and 66 Gy. The impact of radiation dose on survival outcomes were evaluated...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621870/preoperative-short-course-radiotherapy-with-concurrent-and-consolidation-chemotherapies-followed-by-delayed-surgery-in-locally-advanced-rectal-cancer-preliminary-results
#15
Mahdi Aghili, Sarvazad Sotoudeh, Reza Ghalehtaki, Mohammad Babaei, Borna Farazmand, Mohammad-Sadegh Fazeli, Amir Keshvari, Peiman Haddad, Farshid Farhan
PURPOSE: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. MATERIALS AND METHODS: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621869/intensity-modulated-radiation-therapy-a-review-with-a-physics-perspective
#16
REVIEW
Byungchul Cho
Intensity-modulated radiation therapy (IMRT) has been considered the most successful development in radiation oncology since the introduction of computed tomography into treatment planning that enabled three-dimensional conformal radiotherapy in 1980s. More than three decades have passed since the concept of inverse planning was first introduced in 1982, and IMRT has become the most important and common modality in radiation therapy. This review will present developments in inverse IMRT treatment planning and IMRT delivery using multileaf collimators, along with the associated key concepts...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29580046/initial-clinical-outcomes-of-proton-beam-radiotherapy-for-hepatocellular-carcinoma
#17
Jeong Il Yu, Gyu Sang Yoo, Sungkoo Cho, Sang Hoon Jung, Youngyih Han, Seyjoon Park, Boram Lee, Wonseok Kang, Dong Hyun Sinn, Yong-Han Paik, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Hee Chul Park
PURPOSE: This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. MATERIALS AND METHODS: HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST)...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29506326/prognostic-significance-of-adjuvant-radiation-therapy-in-adenocarcinoma-of-the-cecum
#18
Sare Hosseini, Ali Mohammad Bananzadeh, Mohammad Mohammadianpanah, Roham Salek, Ali Taghizadeh-Kermani
PURPOSE: Local recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate the potential role of adjuvant radiation therapy on oncologic outcomes of patients with adenocarcinoma of the cecum. MATERIALS AND METHODS: This retrospective study was carried out at three large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of 162 patients with adenocarcinoma of the cecum that were treated and followed up between 2000 and 2013...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29506325/the-impact-of-continuous-positive-airway-pressure-on-radiation-dose-to-heart-and-lung-during-left-sided-postmastectomy-radiotherapy-when-deep-inspiration-breath-hold-technique-is-not-applicable-a-case-report
#19
Whoon Jong Kil, Tabitha Pham, Sabbir Hossain, Juan Casaigne, Kellie Jones, Mohammad Khalil
Deep inspiration breathing hold (DIBH) compared to free-breathing (FB) during radiotherapy (RT) has significantly decreased radiation dose to heart and has been one of the techniques adopted for patients with breast cancer. However, patients who are unable to make suitable deep inspiration breath may not be eligible for DIBH, yet still need to spare the heart and lung during breast cancer RT (left-sided RT in particular). Continuous positive airway pressure (CPAP) is a positive airway pressure ventilator, which keeps the airways continuously open and subsequently inflates the thorax resembling thoracic changes from DIBH...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29262672/dosimetric-comparison-between-modulated-arc-therapy-and-static-intensity-modulated-radiotherapy-in-thoracic-esophageal-cancer-a-single-institutional-experience
#20
Kyu Hye Choi, Jina Kim, Sea-Won Lee, Young-Nam Kang, HongSeok Jang
PURPOSE: The objective of this study was to compare dosimetric characteristics of three-dimensional conformal radiotherapy (3D-CRT) and two types of intensity-modulated radiotherapy (IMRT) which are step-and-shoot intensity modulated radiotherapy (s-IMRT) and modulated arc therapy (mARC) for thoracic esophageal cancer and analyze whether IMRT could reduce organ-at-risk (OAR) dose. MATERIALS AND METHODS: We performed 3D-CRT, s-IMRT, and mARC planning for ten patients with thoracic esophageal cancer...
March 2018: Radiation Oncology Journal
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