journal
MENU ▼
Read by QxMD icon Read
search

Journal of Comparative Effectiveness Research

journal
https://www.readbyqxmd.com/read/28699780/depression-anxiety-and-stress-severities-in-multiple-sclerosis-patients-using-injectable-versus-oral-treatments
#1
Fawaz Al-Hussain, Noura Al-Salloum, Naael Alazwary, Jameelah Saeedi, Sara Howaidi, Abdulkader Daif
AIM: Studies on multiple sclerosis in Saudi Arabia remain scant, particularly studies on the psychological aspects. This study measures severities of depression, anxiety and stress, and compares them to the used disease-modifying treatment. MATERIALS & METHODS: Cross-sectional study using a phone questionnaire targeting 452 Saudi patients with relapsing-remitting multiple sclerosis following in King Khalid University Hospital, King Fahad Medical City or Security Forces Hospital...
July 12, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28699779/indication-specific-pricing-of-pharmaceuticals-in-the-us-healthcare-system
#2
Steven D Pearson, William B Dreitlein, Chris Henshall, Adrian Towse
AIM: To explore the potential of indication-specific pricing (ISP) of pharmaceuticals and to discuss prospects for implementation in the US healthcare system. MATERIALS & METHODS: The Institute for Clinical and Economic Review convened a policy forum with 44 healthcare leaders from 22 payer and life sciences companies. Models of ISP were discussed. RESULTS: Payers and drug manufacturers saw the potential benefits of an ISP system that balances affordability for payers, sustainability for manufacturers and access for patients...
July 12, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28699771/comparative-effectiveness-of-surgery-versus-antibiotics-in-acute-appendicitis-a-systematic-review
#3
Stephanie D Talutis, Frederick Thurston Drake
AIM: To review outcomes of surgical and antibiotic management of acute appendicitis. METHODS: 11 prospective studies comparing surgical versus antibiotic management of acute appendicitis over a 21-year period were reviewed. RESULTS: Antibiotic management is successful in most cases of uncomplicated acute appendicitis. The need for crossover in management and recurrent appendicitis were low among all studies. For those patients who ultimately required surgery, no increased complications were observed...
July 12, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28699769/deriving-more-value-from-rwe-to-ensure-timely-access-of-medicines-by-patients
#4
Sarah Wamala Andersson, Mattias Kyhlstedt
No abstract text is available yet for this article.
July 12, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28686060/show-me-the-money-an-analysis-of-underserved-stakeholders-funding-priorities-in-patient-centered-outcomes-research-domains
#5
Stephanie Solomon Cargill, Lauren Lyn Baker, Susan Dorr Goold
AIM: Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS: Academic and community partners collaborated to develop an Ipad exercise to facilitate group deliberation about PCOR funding priorities. Sixteen groups (n = 183) of underserved individuals in both urban and rural areas participated...
July 7, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28686057/patient-relevant-outcomes-associated-with-generic-tamsulosin-levothyroxine-and-amphetamine-in-the-fda-adverse-event-reporting-system-a-pilot-study
#6
Sathiya Priya Marimuthu, Geetha Iyer, Jodi B Segal, Sonal Singh
AIM: Patient-reported outcomes associated with adverse events (AEs) reported with generics have not been evaluated. To map AEs associated with generics to the NIH Patient-reported Outcomes Measurement Information System. METHODS: We mapped 381 AEs from 148 case reports of generic tamsulosin, levothyroxine and amphetamine/dextroamphetamine to the physical, mental and social domain of the NIH Patient-Reported Outcomes Measurement Information System after reviewing 1237 case reports in the US FDA's Adverse Event Reporting System (FAERS; 2011-2013)...
July 7, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28686055/a-stakeholder-informed-randomized-controlled-comparative-effectiveness-study-of-an-order-prescribing-intervention-to-improve-colony-stimulating-factor-use-for-cancer-patients-receiving-myelosuppressive-chemotherapy-the-tracer-study
#7
Aasthaa Bansal, Sean D Sullivan, Dawn L Hershman, Gary H Lyman, William E Barlow, Jeannine S McCune, Scott D Ramsey
Colony stimulating factors (CSF) are widely prescribed to avoid febrile neutropenia (FN) among cancer patients receiving chemotherapy, but studies show their use is often not consistent with practice guidelines. In addition, there is limited high quality evidence assessing benefits and harms of primary prophylactic-CSF (PP-CSF) in the setting of chemotherapy that poses an intermediate risk of FN. To address these issues, with funding from the Patient Centered Outcomes Research Institute (PCORI) and the National Cancer Institute's Community Oncology Research Program, SWOG is sponsoring a prospective, cluster randomized controlled pragmatic trial of an automated order entry protocol for PP-CSF among patients with breast, lung and colorectal cancer receiving myelosuppressive chemotherapy, with a nested randomized controlled trial of PP-CSF for patients receiving intermediate risk chemotherapy...
July 7, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28660802/efficacy-and-safety-of-ustekinumab-in-the-induction-therapy-of-tnf-%C3%AE-refractory-crohn-s-disease-patients-a-systematic-review-and-meta-analysis
#8
Paweł Kawalec, Paweł Moćko, Iwona Malinowska-Lipien, Tomasz Brzostek
AIM: The aim of the systematic review and meta-analysis was to assess the efficacy and safety of ustekinumab in the induction therapy of anti-TNF-α failure patients with Crohn's disease. METHODS: A systematic literature search was conducted in Medline (PubMed), EMBASE, Cochrane Library until 30 December 2016. We included randomized controlled trials that compared efficacy (clinical response and remission) and safety profile of ustekinumab in TNF-α failure Crohn's disease patients; primary and secondary TNF-α nonresponders or intolerant patients were also assessed...
June 29, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28627930/randomized-comparative-efficacy-and-safety-study-of-intermittent-simvastatin-versus-fenofibrate-in-hemodialysis
#9
Aya M Abdel Magid, Maggie M Abbassi, Essam Eldin M Iskander, Osama Mohamady, Samar F Farid
AIM: Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients. PATIENTS & METHODS: Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment. RESULTS: After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0...
June 19, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621558/patient-engagement-in-patient-centered-outcomes-research-challenges-facilitators-and-actions-to-strengthen-the-field
#10
Lauren E Ellis, Nancy E Kass
AIM: To describe challenges to and facilitators of patient engagement to inform future strategies and suggested actions to strengthen engagement. METHODS: Interviews with 19 principal investigators of projects funded by the Patient-Centered Outcomes Research Institute and with 33 patients from 18 of the 19 projects. RESULTS: Facilitators included using existing resources, having clear goals, educating patients and treating patients respectfully...
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621553/attitudes-toward-comparative-effectiveness-research-and-patient-engagement-among-reproductive-health-clinicians
#11
Julia Kohn, Zoe Unger, Jennifer Dolatshahi, Hannah Simons, Alison Rein
AIM: To assess reproductive health clinicians' knowledge of and attitudes toward comparative effectiveness research (CER), patient-centered outcomes research (PCOR) and patient engagement in research. MATERIALS & METHODS: Web-based survey of reproductive health clinicians. RESULTS: Among 103 responding clinicians, familiarity with CER and PCOR was moderate (35 and 44%, respectively). Once definitions were provided, most respondents agreed with the potential positive impacts of CER and patient engagement (65-87%), the importance of PCOR (95-99%) and that their patients might be interested in engaging in research as more than subjects (93%)...
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621551/strengthening-stakeholder-engaged-research-and-research-on-stakeholder-engagement
#12
Kristin N Ray, Elizabeth Miller
Stakeholder engagement is an emerging field with little evidence to inform best practices. Guidelines are needed to improve the quality of research on stakeholder engagement through more intentional planning, evaluation and reporting. We developed a preliminary framework for planning, evaluating and reporting stakeholder engagement, informed by published conceptual models and recommendations and then refined through our own stakeholder engagement experience. Our proposed exploratory framework highlights contexts and processes to be addressed in planning stakeholder engagement, and potential immediate, intermediate and long-term outcomes that warrant evaluation...
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621550/the-use-of-digital-technologies-to-collect-patient-data-in-outcomes-research
#13
Bill Byrom, Bill Row
No abstract text is available yet for this article.
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28556675/a-new-modeling-approach-allowing-prediction-and-comparison-of-the-long-term-outcomes-of-treatments-for-hemophilia-b
#14
Marjolijn van Keep, Christina Stentoft Hoxer, Matthew Hemstock, Andreas Velsing Groth, Christopher Knight
AIM: To develop a modeling approach to compare clinical outcomes of nonacog beta pegol to a standard-acting factor IX (FIX) product. METHODS: Regression analysis linked FIX activity to bleed rates. Pharmacokinetic parameters were used to estimate FIX activity over time. The probability of bleeds was estimated for both treatment arms. A Markov model estimated the presence of target joints and annualized bleed rates (ABRs). RESULTS: Higher FIX activity showed reduced ABRs (p < 0...
May 30, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28541099/cost-effectiveness-analysis-of-endoscopic-eradication-therapy-for-treatment-of-high-grade-dysplasia-in-barrett-s-esophagus
#15
Alex Filby, Matthew Taylor, Gideon Lipman, Laurence Lovat, Rehan Haidry
AIM: The aim was to evaluate the cost-effectiveness of endoscopic eradication therapy (EET) with combined endoscopic mucosal resection and radiofrequency ablation for the treatment of high-grade dysplasia (HGD) arising in patients with Barrett's esophagus compared with endoscopic surveillance alone in the UK. MATERIALS & METHODS: The cost-effectiveness model consisted of a decision tree and modified Markov model. A lifetime time horizon was adopted with the perspective of the UK healthcare system...
May 25, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28511548/quality-adjusted-life-year-difference-in-patients-with-predominant-negative-symptoms-of-schizophrenia-treated-with-cariprazine-and-risperidone
#16
Bertalan Németh, Anett Molnár, Ron Akehurst, Margit Horváth, Kristóf Kóczián, György Németh, Árpád Götze, Zoltán Vokó
AIM: Our study aimed at estimating differences in quality-adjusted life year (QALY) gain for patients with predominant negative symptoms of schizophrenia treated with cariprazine compared with risperidone. MATERIALS & METHODS: A Markov model was built, based on the Mohr-Lenert approach and data derived from clinical trials, to estimate potential QALY gains of patients. RESULTS: Patients had higher probability of reaching better health states treated with cariprazine compared with risperidone...
May 17, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485619/characteristics-and-treatment-patterns-among-us-patients-with-hairy-cell-leukemia-a-retrospective-claims-analysis
#17
Victoria Divino, Sudeep Karve, Andrew Gaughan, Mitch DeKoven, Guozhi Gao, Kevin B Knopf, Mark C Lanasa
AIM: Describe hairy cell leukemia (HCL) treatment patterns using a large, nationally representative US database. PATIENTS & METHODS: Adults newly diagnosed with HCL (1 January 2006 to 30 June 2014) with continuous health plan enrollment ≥180 days pre- and 90 days post-diagnosis were identified from the QuintilesIMS PharMetrics Plus Health Plan Claims Database. Treatment patterns by line of therapy were assessed over the variable follow-up. RESULTS: Among 749 HCL patients (77...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485191/familial-clustering-of-atrial-fibrillation-and-comparative-longitudinal-outcomes-of-familial-and-non-familial-atrial-fibrillation
#18
Anna Gundlund, Jonas B Olesen, Eric D Peterson, Gunnar H Gislason, Emil L Fosbøl
Several studies have suggested that family history of atrial fibrillation (AF) is an important risk factor for AF, with several specific genetic regions now implicated through Genome Wide Association Studies. In addition, familial AF is associated with earlier age of onset and affects patients with fewer comorbid conditions than their non-familial counterparts. While those with familial AF have worse symptoms, all-cause mortality and risk of thromboembolic complications are similar among familial and non-familial AF patients...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485178/adoption-of-the-hpv-vaccine-a-case-study-of-three-emerging-countries
#19
Araceli Caro Martínez, Jaime Espín Balbino, Alexandre Lemgruber, Eva Martín Ruiz, Antonio Olry de Labry Lima, Leticia García Mochón, Fernanda Lessa
BACKGROUND: The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries, due to its potential to reduce the impact of HPV-related diseases. This case study sheds new light about the variety of HTA arrangements, methods and processes involved in the adoption and use of HPV vaccines in a selected sample of central, eastern and southern Europe and Latin America and the Caribbean, all of them emerging in the use of HTA. MATERIALS & METHODS: A multi-country case study was designed...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485177/querying-stakeholders-to-inform-comparative-effectiveness-research
#20
Yoon Duk Hong, Daisuke Goto, C Daniel Mullins
Despite the growing recognition of the value of stakeholder engagement in research, there is limited guidance on effectively eliciting stakeholder views during the comparative effectiveness research (CER) process. This article outlines the potential role of each stakeholder (patient, provider, policymaker and payer) throughout the CER process and provides examples of practical questions that researchers can ask the four primary stakeholder groups at each step of the CER process. This guide aims to assist in the development of meaningful stakeholder-researcher shared decision-making to incorporate stakeholder views in the design, conduct and dissemination of patient-centered CER...
May 9, 2017: Journal of Comparative Effectiveness Research
journal
journal
43925
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"