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Journal of Comparative Effectiveness Research

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https://www.readbyqxmd.com/read/28326827/factors-influencing-patients-receptiveness-to-evidence-based-recommendations-during-the-clinical-encounter
#1
Cara Stepanczuk, Nyna Williams, Katie Morrison, Charlene Kemmerer
AIM: To identify the factors that promote or interfere with evidence-based clinical decisions from the patient perspective. MATERIALS & METHODS: We developed four hypothetical scenarios with clinical decisions, such as whether to pursue testing for a chronic condition. We conducted eight focus groups to better understand the influences on individuals' decisions in the context of the scenarios. RESULTS: A patient's relationship with a physician emerged as the strongest influence on whether participants would accept or reject a physician's recommendation...
February 28, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28173732/patient-caregiver-and-clinician-views-on-engagement-in-comparative-effectiveness-research
#2
Laura P Forsythe, Lori B Frank, Thomas A Workman, Tandrea Hilliard, Daniel Harwell, Lauren Fayish
AIM: Describe patient, caregiver and clinician views toward engagement as partners in health research. MATERIALS & METHODS: Online surveys of patients and caregivers managing rare (n = 560 patients, n = 609 caregivers) or chronic conditions (n = 762 patients, n = 776 caregivers) and practicing clinicians (n = 638). RESULTS: Over half of respondents were unfamiliar with the concept of partnering with researchers but most expressed interest in working in a research partnership...
February 8, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28173724/patient-caregiver-and-clinician-use-of-comparative-effectiveness-research-findings-in-care-decisions-results-from-a-national-study
#3
Lori B Frank, Laura P Forsythe, Thomas A Workman, Tandrea Hilliard, Mary Lavelle, Daniel Harwell, Lauren Fayish
AIM: To assess awareness, use and attitudes concerning comparative effectiveness research (CER) findings. MATERIALS & METHODS: Online surveys of patients and caregivers managing rare (n = 560 patients, n = 609 caregivers) or chronic conditions (n = 762 patients, n = 776 caregivers), and practicing clinicians (n = 638). RESULTS: Less than half of patients and caregivers reported exposure to any type of CER findings in the past 12 months. Of those, over half identify healthcare professionals as the information source, yet only 10% of clinicians indicated they were 'very familiar' with CER...
February 8, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28173710/health-researcher-views-on-comparative-effectiveness-research-and-research-engagement
#4
Laura P Forsythe, Lori B Frank, Thomas A Workman, Amanda Borsky, Tandrea Hilliard, Daniel Harwell, Lauren Fayish
AIM: To understand researcher capability for and interest in patient-centered comparative effectiveness research (PC-CER), particularly related to engaging with patients/caregivers. MATERIALS & METHODS: Web-based survey of 508 health researchers recruited via professional health research organizations. RESULTS: Most respondents (94%) were familiar with CER and many (69%) reported having previously conducting some form of CER. Most respondents were familiar with (81%) and interested in (87%) partnering with patients and/or caregivers in research...
February 8, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28142254/learning-effect-and-diffusion-of-innovative-medical-devices-the-case-of-transcatheter-aortic-valve-implantation-in-italy
#5
Giuditta Callea, Maria Caterina Cavallo, Rosanna Tarricone, Aleksandra Torbica
AIM: We investigated the diffusion of transcatheter aortic valve implantation (TAVI) since its introduction into the Italian market aimed at identifying the potential drivers of uptake and diffusion at hospital and regional levels. MATERIALS & METHODS: We estimated the determinants of TAVI diffusion in Italy from 2007 to 2015 with a regression analysis based on registry data. RESULTS: Since 2007, TAVI has shown significant diffusion rates in Italy...
February 1, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28128640/corrigendum
#6
(no author information available yet)
No abstract text is available yet for this article.
January 27, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28120623/the-comparative-effectiveness-of-antiretroviral-therapies-for-hiv-evidence-to-inform-precision-public-health
#7
Edward J Mills, Steve Kanters, Nathan Ford
No abstract text is available yet for this article.
January 25, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28118737/publication-in-2005-recommended-the-prototype-for-the-patient-centered-outcomes-research-institute
#8
Joel Kupersmith
No abstract text is available yet for this article.
January 25, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28118731/cost-effectiveness-of-different-strategies-for-treatment-relapsing-remitting-multiple-sclerosis
#9
Aseel Bin Sawad, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, Fatema Turkistani
AIM: To compare the cost-effectiveness of different disease-modifying therapies' strategies for treatment of relapsing-remitting multiple sclerosis. METHODS: A Markov model was developed to assess the cost-effectiveness and incremental cost-effectiveness ratios for different strategies of using disease-modifying therapies from a US third-party payer perspective. All costs were converted to 2014 US$. RESULTS: Over 20 years, the total costs per patient were estimated at US$161,136...
January 25, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28114803/comparative-effectiveness-research-around-the-globe-a-valuable-tool-for-achieving-and-sustaining-universal-healthcare
#10
Kalipso Chalkidou
No abstract text is available yet for this article.
January 24, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28114798/metoclopramide-as-intermittent-and-continuous-infusions-in-critically-ill-patients-a-pilot-randomized-clinical-trial
#11
Masoume Malekolkottab, Hossein Khalili, Mostafa Mohammadi, Masoud Ramezani, Anahid Nourian
AIM: Metoclopramide is commonly used as a prokinetic agent in critically ill patients with enteral feeding intolerance. OBJECTIVES: In this study, noninferiority of metoclopramide as intermittent versus continuous infusion was examined in critically ill patients with enteral feeding intolerance. METHODS: Forty critically ill adults patients were assigned to receive metoclopramide as either intermittent (10 mg every 6 h) or continuous (2 mg/h) infusion...
January 24, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28114795/efficacy-and-safety-of-apt198k-for-the-treatment-of-infantile-colic-a-pilot-study
#12
Yvan Vandenplas, Anca Bacarea, Marius Marusteri, Vlad Bacarea, Mariana Constantin, Mihai Manolache
AIM: Comparing efficacy and safety of APT198K (xyloglucan plus heat-killed Lactobacillus reuteri SGL01 and Bifidobacterium brevis SGB01) versus a lactase dietary supplement as first-line treatment of infantile colic. METHODS: Randomized, multicenter, open-label, parallel group, active-controlled study, in 46 infants aged 3-16 weeks with infantile colic, receiving APT198K or a lactase dietary supplement for 10 days. RESULTS: Number and duration of crying episodes decreased significantly versus baseline in both groups...
January 24, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28118752/the-impact-of-adjunctive-guanfacine-extended-release-on-stimulant-adherence-in-children-adolescents-with-attention-deficit-hyperactivity-disorder
#13
Juliana Meyers, Kavita Gajria, Sean D Candrilli, Moshe Fridman, Vanja Sikirica
AIM: To assess stimulant adherence among children/adolescents with attention-deficit/hyperactivity disorder (ADHD) augmenting stimulants with guanfacine extended-release (GXR). PATIENTS & METHODS: Inclusion criteria: 6-17 years, ≥1 ADHD diagnosis, ≥1 long-acting and/or short-acting stimulant with GXR augmentation. Modified medication possession ratio (mMPR; days medication available/days in period, excluding medication holidays) was assessed; mMPR <0.80 nonadherent...
March 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28084784/cyd-tdv-dengue-vaccine-systematic-review-and-meta-analysis-of-efficacy-immunogenicity-and-safety
#14
Isabella Piassi Godói, Livia Lovato Pires Lemos, Vânia Eloisa de Araújo, Braúlio Cesar Bonoto, Brian Godman, Augusto Afonso Guerra Júnior
INTRODUCTION: Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia(®)) was the first vaccine to gain regulatory approval to try and address this problem. AIM: Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine. METHOD: Meta-analysis and systematic review. RESULTS: The best and worst immunogenicity results were for DENV4 and DENV1, respectively...
March 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28001117/introducing-volume-6-of-the-journal-of-comparative-effectiveness-research
#15
Laura Dormer
No abstract text is available yet for this article.
January 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27936907/adverse-effects-of-carbamazepine-monotherapy-among-patients-in-nigeria-a-pilot-study-and-implications
#16
Adedunni Olusanya, Olayinka Ogunleye, Brian Godman, Joseph Fadare, Mustafa Danesi
AIM: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients. METHODS: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors. RESULTS: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression...
January 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27935741/barriers-to-evidence-based-physician-decision-making-at-the-point-of-care-a-narrative-literature-review
#17
Kara Contreary, Anna Collins, Eugene C Rich
We conduct a narrative literature review using four real-world cases of clinical decisions to show how barriers to the use of evidence-based medicine affect physician decision-making at the point of care, and where adjustments could be made in the healthcare system to address these barriers. Our four cases constitute decisions typical of the types physicians make on a regular basis: diagnostic testing, initial treatment and treatment monitoring. To shed light on opportunities to improve patient care while reducing costs, we focus on barriers that could be addressed through changes to policy and/or practice at a particular level of the healthcare system...
January 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27935320/missing-laboratory-results-data-in-electronic-health-databases-implications-for-monitoring-diabetes-risk
#18
James H Flory, Jason Roy, Joshua J Gagne, Kevin Haynes, Lisa Herrinton, Christine Lu, Elisabetta Patorno, Azadeh Shoaibi, Marsha A Raebel
AIM: Laboratory test (lab) results may be useful to detect incident diabetes in electronic health record and claims-based studies. RESEARCH DESIGN & METHODS: Using the Mini-Sentinel distributed database, we assessed the value of lab results added to diagnosis codes and dispensing claims to identify incident diabetes. RESULTS: Inclusion of lab results increased the number of diabetes outcomes identified by 21%. In settings where capture of lab results was relatively complete, the absence of lab results was associated with implausibly low rates of the outcome...
January 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27934549/burden-of-illness-and-research-investments-in-translational-sciences-for-pharmaceuticals-in-metastatic-cancers
#19
Wei-Jhih Wang, Justin C Robertson, Anirban Basu
AIM: To explore whether investments in translational sciences for six metastatic cancers follow idiosyncratic returns to those investments rather than levels of burden of illness (BI). METHODS: Associate the number of translational clinical trials in the USA involving oncolytic drugs approved during 2008-2013 and the level (in 2008) and changes (2002-2008 and 2008-2014) in cancer-specific years of life lost. RESULTS: Investments in trials were positively associated only with contemporary changes in BI (2008-2014)...
January 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27934539/healthcare-reform-in-the-middle-east-and-the-usa
#20
Mustafa Z Younis
Mustafa Z Younis speaks to Laura Dormer, Commissioning Editor: Dr Mustafa Z Younis is an internationally recognized scholar and was a member of the Executive Committee of the International Society for Research of Healthcare Financial Management. Dr Younis has authored and published over 200 articles, abstracts and presentations in refereed journals and meetings, and has presented at national and international conferences. Dr Younis has administrative experience as Senior Adviser for the President at Zirve University, Turkey and as Chair of the Department of Health Policy and Management at Florida International University (FL, USA) where he led the accreditation efforts for the Healthcare Management Program...
January 2017: Journal of Comparative Effectiveness Research
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