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Journal of Comparative Effectiveness Research

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https://www.readbyqxmd.com/read/28627930/randomized-comparative-efficacy-and-safety-study-of-intermittent-simvastatin-versus-fenofibrate-in-hemodialysis
#1
Aya M Abdel Magid, Maggie M Abbassi, Essam Eldin M Iskander, Osama Mohamady, Samar F Farid
AIM: Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients. PATIENTS & METHODS: Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment. RESULTS: After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0...
June 19, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621558/patient-engagement-in-patient-centered-outcomes-research-challenges-facilitators-and-actions-to-strengthen-the-field
#2
Lauren E Ellis, Nancy E Kass
AIM: To describe challenges to and facilitators of patient engagement to inform future strategies and suggested actions to strengthen engagement. METHODS: Interviews with 19 principal investigators of projects funded by the Patient-Centered Outcomes Research Institute and with 33 patients from 18 of the 19 projects. RESULTS: Facilitators included using existing resources, having clear goals, educating patients and treating patients respectfully...
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621553/attitudes-toward-comparative-effectiveness-research-and-patient-engagement-among-reproductive-health-clinicians
#3
Julia Kohn, Zoe Unger, Jennifer Dolatshahi, Hannah Simons, Alison Rein
AIM: To assess reproductive health clinicians' knowledge of and attitudes toward comparative effectiveness research (CER), patient-centered outcomes research (PCOR) and patient engagement in research. MATERIALS & METHODS: Web-based survey of reproductive health clinicians. RESULTS: Among 103 responding clinicians, familiarity with CER and PCOR was moderate (35 and 44%, respectively). Once definitions were provided, most respondents agreed with the potential positive impacts of CER and patient engagement (65-87%), the importance of PCOR (95-99%) and that their patients might be interested in engaging in research as more than subjects (93%)...
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621551/strengthening-stakeholder-engaged-research-and-research-on-stakeholder-engagement
#4
Kristin N Ray, Elizabeth Miller
Stakeholder engagement is an emerging field with little evidence to inform best practices. Guidelines are needed to improve the quality of research on stakeholder engagement through more intentional planning, evaluation and reporting. We developed a preliminary framework for planning, evaluating and reporting stakeholder engagement, informed by published conceptual models and recommendations and then refined through our own stakeholder engagement experience. Our proposed exploratory framework highlights contexts and processes to be addressed in planning stakeholder engagement, and potential immediate, intermediate and long-term outcomes that warrant evaluation...
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28621550/the-use-of-digital-technologies-to-collect-patient-data-in-outcomes-research
#5
Bill Byrom, Bill Row
No abstract text is available yet for this article.
June 16, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28556675/a-new-modeling-approach-allowing-prediction-and-comparison-of-the-long-term-outcomes-of-treatments-for-hemophilia-b
#6
Marjolijn van Keep, Christina Stentoft Hoxer, Matthew Hemstock, Andreas Velsing Groth, Christopher Knight
AIM: To develop a modeling approach to compare clinical outcomes of nonacog beta pegol to a standard-acting factor IX (FIX) product. METHODS: Regression analysis linked FIX activity to bleed rates. Pharmacokinetic parameters were used to estimate FIX activity over time. The probability of bleeds was estimated for both treatment arms. A Markov model estimated the presence of target joints and annualized bleed rates (ABRs). RESULTS: Higher FIX activity showed reduced ABRs (p < 0...
May 30, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28541099/cost-effectiveness-analysis-of-endoscopic-eradication-therapy-for-treatment-of-high-grade-dysplasia-in-barrett-s-esophagus
#7
Alex Filby, Matthew Taylor, Gideon Lipman, Laurence Lovat, Rehan Haidry
AIM: The aim was to evaluate the cost-effectiveness of endoscopic eradication therapy (EET) with combined endoscopic mucosal resection and radiofrequency ablation for the treatment of high-grade dysplasia (HGD) arising in patients with Barrett's esophagus compared with endoscopic surveillance alone in the UK. MATERIALS & METHODS: The cost-effectiveness model consisted of a decision tree and modified Markov model. A lifetime time horizon was adopted with the perspective of the UK healthcare system...
May 25, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28511548/quality-adjusted-life-year-difference-in-patients-with-predominant-negative-symptoms-of-schizophrenia-treated-with-cariprazine-and-risperidone
#8
Bertalan Németh, Anett Molnár, Ron Akehurst, Margit Horváth, Kristóf Kóczián, György Németh, Árpád Götze, Zoltán Vokó
AIM: Our study aimed at estimating differences in quality-adjusted life year (QALY) gain for patients with predominant negative symptoms of schizophrenia treated with cariprazine compared with risperidone. MATERIALS & METHODS: A Markov model was built, based on the Mohr-Lenert approach and data derived from clinical trials, to estimate potential QALY gains of patients. RESULTS: Patients had higher probability of reaching better health states treated with cariprazine compared with risperidone...
May 17, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485619/characteristics-and-treatment-patterns-among-us-patients-with-hairy-cell-leukemia-a-retrospective-claims-analysis
#9
Victoria Divino, Sudeep Karve, Andrew Gaughan, Mitch DeKoven, Guozhi Gao, Kevin B Knopf, Mark C Lanasa
AIM: Describe hairy cell leukemia (HCL) treatment patterns using a large, nationally representative US database. PATIENTS & METHODS: Adults newly diagnosed with HCL (1 January 2006 to 30 June 2014) with continuous health plan enrollment ≥180 days pre- and 90 days post-diagnosis were identified from the QuintilesIMS PharMetrics Plus Health Plan Claims Database. Treatment patterns by line of therapy were assessed over the variable follow-up. RESULTS: Among 749 HCL patients (77...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485191/familial-clustering-of-atrial-fibrillation-and-comparative-longitudinal-outcomes-of-familial-and-non-familial-atrial-fibrillation
#10
Anna Gundlund, Jonas B Olesen, Eric D Peterson, Gunnar H Gislason, Emil L Fosbøl
Several studies have suggested that family history of atrial fibrillation (AF) is an important risk factor for AF, with several specific genetic regions now implicated through Genome Wide Association Studies. In addition, familial AF is associated with earlier age of onset and affects patients with fewer comorbid conditions than their non-familial counterparts. While those with familial AF have worse symptoms, all-cause mortality and risk of thromboembolic complications are similar among familial and non-familial AF patients...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485178/adoption-of-the-hpv-vaccine-a-case-study-of-three-emerging-countries
#11
Araceli Caro Martínez, Jaime Espín Balbino, Alexandre Lemgruber, Eva Martín Ruiz, Antonio Olry de Labry Lima, Leticia García Mochón, Fernanda Lessa
BACKGROUND: The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries, due to its potential to reduce the impact of HPV-related diseases. This case study sheds new light about the variety of HTA arrangements, methods and processes involved in the adoption and use of HPV vaccines in a selected sample of central, eastern and southern Europe and Latin America and the Caribbean, all of them emerging in the use of HTA. MATERIALS & METHODS: A multi-country case study was designed...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485177/querying-stakeholders-to-inform-comparative-effectiveness-research
#12
Yoon Duk Hong, Daisuke Goto, C Daniel Mullins
Despite the growing recognition of the value of stakeholder engagement in research, there is limited guidance on effectively eliciting stakeholder views during the comparative effectiveness research (CER) process. This article outlines the potential role of each stakeholder (patient, provider, policymaker and payer) throughout the CER process and provides examples of practical questions that researchers can ask the four primary stakeholder groups at each step of the CER process. This guide aims to assist in the development of meaningful stakeholder-researcher shared decision-making to incorporate stakeholder views in the design, conduct and dissemination of patient-centered CER...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485175/patient-related-beliefs-and-adherence-toward-their-medications-among-the-adult-hypertensive-outpatients-in-tanzania
#13
Mary Jande, Deogratias M Katabalo, Praveen Sravanam, Carol Marwa, Bijal Madlan, Johanita Burger, Brian Godman, Margaret Oluka, Amos Massele, Stanley Mwita
AIM: Hypertension is a leading global health problem requiring lifelong treatment. However, adherence to antihypertensive medicines is a problem, greater among developing countries. Consequently, there is a need to determine current adherence rates and their associations among developing countries to plan future initiatives. MATERIALS & METHODS: Cross-sectional study among adult outpatients with essential hypertension in Tanzania. Predesigned questionnaires were used to gather information on adherence rates and patient-related beliefs...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28482681/how-can-real-world-evidence-be-used-in-practice-to-demonstrate-drug-value-and-improve-patient-care
#14
Laura Dormer
Evidence Europe 2017, Victoria Park Plaza, London, UK, 22-23 February 2017 The Evidence Europe 2017 meeting took place in February 2017 in London (UK). This year's event focused on the use of real-world evidence in practice, both before and after a product has been approved. Speakers and attendees represented a broad spread of stakeholders, including national bodies, industry and academia. The event involved expert presentations, lively panel discussions and networking opportunities, allowing everyone involved to improve their knowledge of how real-world evidence is being used and potential opportunities for the future...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28452226/the-cost-effectiveness-of-blue-light-therapy-in-the-treatment-of-mild-to-moderate-psoriasis
#15
Amir Ansaripour, Hok Bing Thio, Rob Maessen, William Ken Redekop
AIM: To investigate the cost-effectiveness of blue-light therapy versus a two-compound formulation (TCF) (Dovobet(®) gel [calcipotriol and betamethasone]) in mild-to-moderate psoriasis. METHODS: A Markov model was applied to describe the course of disease among Dutch patients with a Psoriasis Area and Severity Index (PASI) score ≤ 10 over a 52-week time horizon. Patients received either 12-week blue-light therapy or two 4-week treatments with TCF. Patients, experiencing no PASI reduction after either therapy, were assumed to receive 12-week ultraviolet B phototherapy...
April 28, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28374618/the-economic-value-of-rapid-deployment-aortic-valve-replacement-via-full-sternotomy
#16
Matt Moore, Glenn R Barnhart, W Randolph Chitwood, John A Rizzo, Candace Gunnarsson, Swetha R Palli, Eugene A Grossi
AIM: To compare the economic value of EDWARDS INTUITY Elite™ (EIE) valve system for rapid-deployment aortic valve replacement (RDAVR) in a full sternotomy (FS) approach (EIE-FS-RDAVR) versus FS-AVR using conventional stented bioprosthesis. DATA & METHODS: A simulation model to compare each treatment's 30-day inpatient utilization and complication rates utilized: clinical end points obtained from the TRANSFORM trial patient subset (EIE-FS-RDAVR) and a best evidence review of the published literature (FS-AVR); and costs from the Premier database and published literature...
April 4, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28353372/satisfaction-quality-of-life-and-perception-of-patients-regarding-burdens-and-benefits-of-vitamin-k-antagonists-compared-with-direct-oral-anticoagulants-in-patients-with-nonvalvular-atrial-fibrillation
#17
Mª Del Mar Contreras Muruaga, José Vivancos, Gemma Reig, Ayoze González, Pere Cardona, José Mª Ramírez-Moreno, Joan Martí, Carmen Suárez Fernández
AIM: To compare the satisfaction of patients treated with vitamin K antagonists (VKA) with that of patients treated with direct oral anticoagulants (DOACs) and to determine the impact on quality of life of both treatments in patients with nonvalvular atrial fibrillation (NVAF). METHODS: Cross-sectional multicenter study in which outpatients with NVAF completed the ACTS (Anti-Clot Treatment Scale), SAT-Q (Satisfaction Questionnaire) and EQ-5D-3L (EuroQol 5 dimensions questionnaire, 3 level version) questionnaires...
March 29, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28350241/comparative-effectiveness-of-delayed-release-dimethyl-fumarate-versus-glatiramer-acetate-in-multiple-sclerosis-patients-results-of-a-matching-adjusted-indirect-comparison
#18
Andrew Chan, Gary Cutter, Robert J Fox, James Xiao, James B Lewin, Michael R Edwards
AIM: Using matching-adjusted indirect comparison, we compared efficacy outcomes in patients with relapsing-remitting multiple sclerosis treated with delayed-release dimethyl fumarate (DMF) or glatiramer acetate (GA). MATERIALS & METHODS: An indirect comparison of DMF (patient-level data) and GA (aggregate data) was conducted, with average baseline characteristics of DMF patients weighted to match those for GA patients. Direct comparison of DMF and GA was conducted in CONFIRM...
March 28, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485691/adoption-of-the-hpv-vaccine-a-case-study-of-three-emerging-countries
#19
Araceli Caro Martínez, Jaime Espín Balbino, Alexandre Lemgruber, Eva Martín Ruiz, Antonio Olry de Labry Lima, Leticia García-Mochón, Fernanda Lessa
BACKGROUND: The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries, due to its potential to reduce the impact of HPV-related diseases. This case study sheds new light about the variety of HTA arrangements, methods and processes involved in the adoption and use of HPV vaccines in a selected sample of central, eastern and southern Europe and Latin America and the Caribbean, all of them emerging in the use of HTA. MATERIALS & METHODS: A multi-country case study was designed...
May 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28118752/the-impact-of-adjunctive-guanfacine-extended-release-on-stimulant-adherence-in-children-adolescents-with-attention-deficit-hyperactivity-disorder
#20
Juliana Meyers, Kavita Gajria, Sean D Candrilli, Moshe Fridman, Vanja Sikirica
AIM: To assess stimulant adherence among children/adolescents with attention-deficit/hyperactivity disorder (ADHD) augmenting stimulants with guanfacine extended-release (GXR). PATIENTS & METHODS: Inclusion criteria: 6-17 years, ≥1 ADHD diagnosis, ≥1 long-acting and/or short-acting stimulant with GXR augmentation. Modified medication possession ratio (mMPR; days medication available/days in period, excluding medication holidays) was assessed; mMPR <0.80 nonadherent...
March 2017: Journal of Comparative Effectiveness Research
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