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Journal of Comparative Effectiveness Research

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https://www.readbyqxmd.com/read/30230361/secukinumab-for-psoriatic-arthritis-comparative-effectiveness-versus-licensed-biologics-apremilast-a-network-meta-analysis
#1
Iain B McInnes, Peter Nash, Christopher Ritchlin, Ernest H Choy, Steve Kanters, Howard Thom, Kunal Gandhi, Luminita Pricop, Steffen M Jugl
AIM: A network meta-analysis using randomized controlled trial data compared psoriatic arthritis (PsA) outcomes (American College of Rheumatology [ACR], Psoriasis Area Severity Index [PASI] and Psoriatic Arthritis Response Criteria [PsARC] response rates) at 12-16 weeks for secukinumab, adalimumab, apremilast, certolizumab, etanercept, golimumab, infliximab and ustekinumab. PATIENTS & METHODS: Trials were identified by systematic review. Separate networks were developed for the full-study populations, biologic-naive patients and biologic-experienced patients...
September 19, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30203668/cost-impact-of-the-transitional-care-model-for-hospitalized-cognitively-impaired-older-adults
#2
Mark V Pauly, Karen B Hirschman, Alexandra L Hanlon, Liming Huang, Kathryn H Bowles, Christine Bradway, Kathleen McCauley, Mary D Naylor
AIM: The goal of this study was to compare postacute care costs of three care management interventions. MATERIALS & METHODS: A total of 202 hospitalized older adults with cognitive impairment received either Augmented Standard Care, Resource Nurse Care or the Transitional Care Model. The Lin method was used to estimate costs at 30 and 180 days postindex hospital discharge. RESULTS: The Transitional Care Model had significantly lower costs than the Augmented Standard Care group at both 30 (p < 0...
September 11, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30192166/meropenem-colistin-versus-meropenem-ampicillin-sulbactam-in-the-treatment-of-carbapenem-resistant-pneumonia
#3
Hossein Khalili, Lida Shojaei, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Alireza Abdollahi, Mahsa Doomanlou
AIM: Efficacy of colistin and ampicillin-sulbactam have not been compared in treatment of ventilator-associated pneumonia due to A. baumannii. Efficacy of colistin and ampicillin-sulbactam in combination with meropenem were compared in treatment of ventilator-associated pneumonia due to carbapenem-resistant A. baumannii. METHOD: 47 patients with ventilator-associated pneumonia due to carbapenem-resistant A. baumannii were randomized to receive meropenem/colistin or meropenem/ampicillin-sulbactam for 14 days...
September 7, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30192159/some-issues-for-the-evaluation-of-noninferiority-trials
#4
Xuanqian Xie, Myra Wang, Vivian Ng, Nancy Sikich
Although published noninferiority trials (NITs) generally conclude that the experimental intervention being studied is noninferior compared with standard therapy or active control, NIT quality is often not satisfactory. We have proposed 14 questions to assist in evaluating the clinical evidence of the experimental versus standard therapy. The aim of these questions is to critically appraise NITs and support proper interpretation of study results. Readers should not only consider whether the confidence interval of the primary effect measure falls within the prespecified noninferiority margin (thus concluding noninferiority), but also assess the similarities between primary and secondary outcomes for the experimental and standard therapy...
September 7, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30192157/m-bioscore-proposing-a-new-statistical-model-for-prognostic-factors-in-metastatic-breast-cancer-patients
#5
Omar Abdel-Rahman
AIM: The current study aims to propose and internally validate 'M-bioscore', which is a model to help predict the outcomes of untreated metastatic breast cancer patients. METHODOLOGY: Surveillance, epidemiology and end results (SEER) database (2010-2013) was accessed. Patients were divided into two groups: a training set and a validation set. Through a Cox proportional model, multivariate analysis for potential prognostic factors was performed. M-bioscore was calculated for all patients...
September 7, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30192155/costs-associated-with-adverse-events-for-systemic-therapies-in-metastatic-melanoma
#6
Alex Z Fu, Zhiyi Li, Jackson Tang, Syed Mahmood, Tyler Whisman, Ying Qiu
AIM: To determine the costs of adverse events (AEs) associated with current metastatic melanoma (MM) therapies. MATERIALS & METHODS: Two retrospective cohort studies were independently conducted using the PharMetrics and MarketScan databases. Included patients were aged ≥18 years, and had ≥1 MM diagnosis and ≥1 claim for systemic therapy from 2004 to 2015. RESULTS: A total of 1654 and 1329 patients were identified in PharMetrics and MarketScan, respectively...
September 7, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30168349/relative-effectiveness-of-sunitinib-versus-everolimus-in-advanced-pancreatic-neuroendocrine-tumors-an-updated-matching-adjusted-indirect-comparison
#7
K Jack Ishak, Michael Rael, Meagen Hicks, Sangeeta Mittal, Martin Eatock, Juan W Valle
AIM: A matching-adjusted indirect comparison (MAIC) of sunitinib and everolimus has been previously reported based on the RADIANT-3 everolimus trial. We performed an analysis using updated overall survival (OS) data based on sunitinib's trial (A6181111). METHODS: The MAIC matched on all baseline characteristics available from both studies. An anchored MAIC was performed for progression-free survival (PFS); an unanchored analysis was deemed more appropriate for OS due to crossover in both trials...
August 31, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30156128/characteristics-of-early-sacubitril-valsartan-patients-and-considerations-for-studies-in-electronic-health-record-data
#8
Joshua J Gagne, Theodore Tsacogianis, Sara Bruce Wirta, James R Rogers, Frederico Calado, Chun-Lan Chang, Stuart J Turner, Raymond G Schlienger, Bogdan Balas, Abdurrahman Abdurrob, Mehdi Najafzadeh, Shirley V Wang
AIM: We examined characteristics of early sacubitril/valsartan users in a large US electronic health records database. PATIENTS & METHODS: We identified three cohorts of patients with heart failure (HF): sacubitril/valsartan patients with a prior HF diagnosis; patients with HF with reduced ejection fraction; and patients with HF treated with an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker and a β-blocker. RESULTS: Sacubitril/valsartan patients were younger than patients in the other cohorts; the mean age of sacubitril/valsartan patients increased by 2 years in the first 15 months of marketing...
August 29, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30136603/real-world-assessment-of-treatment-with-extended-release-topiramate-trokendi-xr-%C3%A2-and-comparison-with-previous-immediate-release-topiramate-treatment
#9
Welton O'Neal, Elizabeth E Hur, Tesfaye Liranso, Barry Patel
AIM: Examine clinical profile of extended-release topiramate (Trokendi XR® ) and compare treatment-emergent adverse events (TEAEs) associated with Trokendi XR versus previous immediate-release topiramate (TPM-IR) treatment. PATIENTS & METHODS: Pilot retrospective study analyzing data extracted from medical charts of patients ≥6 years of age prescribed Trokendi XR. RESULTS: Trokendi XR was the most commonly used to prevent migraine...
August 23, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30132371/the-effectiveness-of-the-follow-up-of-patients-after-surgery-due-to-cancer-of-the-head-and-neck
#10
Joanna Jackowska, Yogen Abelak, Krzysztof Piersiala, Malgorzata Wierzbicka
AIM: The aim of this study was to assess the effectiveness of the follow-up (FU) of patients after head and neck cancer treatment. MATERIALS & METHODS: This is a retrospective cross-sectional study and concerns the analysis of outpatient records of 85 women and 355 men who reported at FU visits between 2011 and 2016 in ENT Department in the University Of Medical Sciences in Poznan, Poland. RESULTS: The value of the FU scheme was confirmed by a high rate of recurrence detected in a medical examination (60%) and routine imaging studies (27%), as opposed to only 13% in spontaneous reports...
August 22, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30132342/development-and-validation-of-a-health-policy-model-of-type-2-diabetes-in-chinese-setting
#11
Bin Wu, Jing Ma, Suhua Zhang, Lei Zhou, Haixiang Wu
AIM: Due to the difference in epidemiology and outcomes between eastern and western populations with Type 2 diabetes mellitus (T2DM), an important challenge is determining how useful the outcomes from diabetes models based on western populations are for eastern patients. Consequently, the principal aim of this study was to develop and validate a Health Policy Model (Chinese Outcomes Model for T2DM [COMT]) for supporting Chinese medical and health economic studies. METHODS: The model is created to simulate a series of important complications of T2DM diabetes based on the latest Risk Equations for Complications of Type 2 Diabetes, which was adjusted by adding the adjustment regulator to the linear predictor within the risk equation...
August 22, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30130977/conditional-power-for-assessing-population-interventions
#12
Alexander M Walker, Paul M Coplan, Daniel C Beachler
AIM: To calculate conditional power in comparative two-period studies with previously observed baseline data. METHOD: Isolate the variability attributable to the yet-to-observed data and modify the standard power formulae. RESULTS: For illustration, we examine rates of opioid overdose before and after a reformulation of one opioid product. The null hypothesis posited no impact of the reformulation, alternative hypotheses posited possible impacts, and ancillary hypotheses posited different secular pre-post changes directly observable in comparators...
August 22, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30130972/assessing-the-robustness-of-direct-meta-analysis-in-the-presence-of-heterogeneity
#13
Claire Ainsworth
AIM: To assess robustness of findings in recent systematic reviews of atypical antipsychotics in schizophrenia patients in the presence of heterogeneity. METHODS: Relative efficacy was measured in seven direct comparisons of mean difference (MD) in average positive and negative syndrome scale total score and comparisons between conventional meta-analysis results and four alternate meta-analytic strategies using the difference in MD (ΔMD). RESULTS: MDs in positive and negative syndrome scale total score were smaller in the conventional meta-analyses than those for three of the four analytic strategies...
August 22, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30129776/systematic-review-and-network-meta-analysis-effect-of-biologics-on-radiographic-progression-in-rheumatoid-arthritis
#14
Erin Murray, Alexandra Ellis, Yekaterina Butylkova, Martha Skup, Jasmina Kalabic, Vishvas Garg
AIM: To evaluate the comparative effectiveness of biologics in inhibiting radiographic progression among rheumatoid arthritis (RA) patients. MATERIALS & METHODS: Bayesian network meta-analysis of published trials investigating the USA FDA approved biologics treatment in RA patients, using methotrexate (MTX) as the reference comparator. RESULTS: Nine trials met the inclusion criteria for base case analysis. Compared with MTX, most biologics (except golimumab) + MTX had significantly lower rates of radiographic progression at 1 year...
August 21, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30129771/impact-of-initiating-long-acting-injectable-antipsychotics-on-hospitalization-in-patients-with-bipolar-i-disorder
#15
Tingjian Yan, Mallik Greene, Eunice Chang, Maëlys Touya, Michael S Broder
AIM: To compare risk of hospitalization in patients with bipolar I disorder (BD-I) initiating long-acting injectable antipsychotics (LAIs). MATERIALS & METHODS: Using Truven Health Analytics MarketScan® (Medicaid, Commercial and Medicare Supplemental) databases (2012-2016), patients (≥18 years) with BD-I with a LAI (aripiprazole once monthly [AOM 400], fluphenazine-LAI, haloperidol-LAI, risperidone-LAI and paliperidone-4-week-LAI) were identified. RESULTS: The adjusted odds of having hospitalization were significantly higher in haloperidol-LAI (Odds ratio [95% CI]: 1...
August 21, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30107762/comparative-effectiveness-of-avelumab-versus-chemotherapy-in-merkel-cell-carcinoma-innovative-use-of-patient-insights
#16
Murtuza Bharmal, Alexia Marrel, Meliessa Hennessy, Fatoumata Fofana, Jérémy Lambert, Benoit Arnould
AIM: To assess patient experience with chemotherapy and avelumab in metastatic Merkel cell carcinoma (mMCC). METHODS: In the JAVELIN Merkel 200 trial, chemotherapy-refractory mMCC patients could participate in optional qualitative interviews at baseline documenting recollection of previous chemotherapy experience, and at weeks 13/25 documenting current experience with avelumab. Functional Assessment of Cancer Therapy subscale for melanoma questionnaire (FACT-M) was administered in parallel...
August 15, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30101611/patient-characteristics-and-bleeding-events-in-nonvalvular-atrial-fibrillation-patients-treated-with-apixaban-or-vitamin-k-antagonists-real-world-evidence-from-italian-administrative-databases
#17
Sreeram Ramagopalan, Victoria Allan, Stefania Saragoni, Luca Degli Esposti, Davide Alessandrini, Valentina Perrone, Stefano Buda, Gillian Stynes, Caterina Toma, Francesco DeSolda
AIM: This study aimed to evaluate the risk of major bleeding among two cohorts of nonvalvular atrial fibrillation patients newly initiating a vitamin K antagonist (VKA) or apixaban in a real-world setting in Italy. PATIENTS & METHODS: A retrospective study using a large administrative database of Italian local health units was performed, using data from ten local health units and patients were included from the date of new initiation of apixaban or VKAs from January 2012 to June 2015...
August 13, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30070596/comparing-outcomes-between-barbed-and-conventional-sutures-in-patients-undergoing-knee-or-hip-arthroplasty
#18
Nadia Sutton, Niels-Derrek Schmitz, Stephen S Johnston
AIM: To compare outcomes between barbed sutures and conventional sutures among patients undergoing knee or hip arthroplasty. MATERIALS & METHODS: Retrospective study of patients (aged ≥18 years) undergoing elective knee/hip arthroplasty for osteoarthritis between 1 January 2013 and 1 September 2015. Patients were classified as: any Stratafix™ Knotless Tissue Control Devices (barbed suture group) used for closure vs. conventional sutures only (conventional suture group)...
August 2, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29944008/comparative-effectiveness-from-a-single-arm-trial-and-real-world-data-alectinib-versus-ceritinib
#19
Jessica Davies, Michael Martinec, Paul Delmar, Mathieu Coudert, Walter Bordogna, Sophie Golding, Reynaldo Martina, Gracy Crane
AIM: To compare the overall survival of anaplastic lymphoma kinase-positive non-small-cell lung cancer patients who received alectinib with those who received ceritinib. MATERIALS & METHODS: Two treatment arms (alectinib [n = 183] and ceritinib [n = 67]) were extracted from clinical trials and an electronic health record database, respectively. Propensity scores were applied to balance baseline characteristics. Kaplan-Meier and multivariate Cox regression were conducted...
June 26, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29943647/evaluation-of-a-mobile-social-networking-application-for-improving-diabetes-type-2-knowledge-an-intervention-study-using-whatsapp
#20
Alanzi Turki, Bah Sulaiman, Alzahrani Sara, Alshammari Sirah, Almunsef Fatima
AIM: The aim of this study is to evaluate the WhatsApp social networking application for improving knowledge, self-efficacy and awareness about diabetes management. METHODOLOGY: The study was conducted with intervention and control groups at Teaching Hospital in Al-Khobar, Saudi Arabia. The intervention group received weekly educational messages using WhatsApp, while the control group received regular care. RESULTS: Statistically, compared with the control group, the diabetes knowledge and self-efficacy of the intervention group increased significantly after the intervention with the WhatsApp application...
June 26, 2018: Journal of Comparative Effectiveness Research
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