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Case Reports in Pathology

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https://www.readbyqxmd.com/read/28105379/a-rare-case-of-extramedullary-t-myeloid-mixed-phenotype-acute-leukemia-with-t-1-5-q23-q33
#1
Ahmad Monabati, Akbar Safaei, Sadat Nouri, Moeinadin Safavi, Freidoon Solhjoo
Mixed phenotype acute leukemia (MPAL) is a rare neoplasm which accounts for 2-5% of all leukemias and it is classified under heading of acute leukemia of ambiguous lineage in 2008 WHO classification. This patient was a 61-year-old man who presented with malaise and weakness. In physical examination there was cervical and axillary lymphadenopathy. Paraclinical evaluation revealed anemia (Hb = 10.3 g/dL, MCV = 108 fl). Histologic sections of the axillary lymph node revealed leukemic involvement with two discrete populations of cells in immunohistochemistry...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28105378/a-nonpalpable-nodule-in-ectopic-axillary-breast-tissue-consider-phyllodes-tumor
#2
Eva Ruvalcaba-Limón, Verónica Bautista-Piña, Julio Ramírez-Bollas, Ruby Espejo-Fonseca, Sergio Rodríguez-Cuevas
Benign and malignant pathology can develop in ectopic axillary breast tissue, such as fibroadenomas, phyllodes tumors, and breast cancer. We present a rare case of an asymptomatic 43-year-old woman with an axillary nodule which was identified during screening mammography within ectopic axillary breast tissue, initially considered as a suspicious lymph node. Radiologic studies were considered as Breast Imaging-Reporting Data System (BI-RADS) 4. A hyperdense, lobular, and well-circumscribed nodule was identified in mammogram while the nodule by ultrasound (US) was hypoechoic with indistinct microlobular margins, without vascularity by Doppler, and measuring 1...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28097030/a-foregut-duplication-cyst-of-the-stomach-in-association-with-a-gastrointestinal-stromal-tumor-and-a-leiomyoma-a-case-report
#3
Andréanne Gagné, Olga Sazonova, Simon Marceau, Martine Périgny, Philippe Joubert
Objectives. Duplication cysts are rare benign lesions usually arising in the gastrointestinal tract. We report a case of a 52-year-old woman with an incidental gastric mass found on computed tomography during a pregraft workup for a familial cardiomyopathy. Methods. The mass was completely excised by partial gastrectomy and gross examination revealed a cystic lesion containing two small solid nodules in its wall. Microscopic evaluation and immunohistochemistry study were performed to further characterize the cyst and the nodules...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28078158/unusual-presentation-of-primary-squamous-cell-carcinoma-of-mandible
#4
Karpagavalli Shanmugasundaram, Sathasiva Subramanian, Vaishnavi Vedam, Vimal Kumar
Carcinoma arising primarily from the jaw is a locally aggressive lesion with poor prognosis. Primary intraosseous carcinoma (PIOC) lesion develops either de novo remnants of odontogenic epithelium, odontogenic cyst/tumor, epithelium remnants, or/and salivary gland residues. We describe very interesting case of primary intraosseous carcinoma of mandible. This extensive lesion was sent for oncological opinion and further management. Due to the uncertainty of diagnostic criteria of PIOC, only few cases of this lesion with a typical presentation have been reported...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28078157/dendritic-fibromyxolipoma-of-the-pyriform-sinus-a-case-report-and-review-of-the-literature
#5
Abdulrahim AlAbdulsalam, Maha Arafah
Dendritic fibromyxolipoma is a rare and distinctive soft tissue neoplasm that is considered by many authors as a variant of spindle cell lipoma and characterized by the presence of dendritic cytoplasmic processes, plexiform vascular pattern, and keloidal collagen. It has never been reported in the larynx and hypopharynx. Its rarity and the potential to mistake it as a more clinically aggressive myxoid soft tissue neoplasm highlight the importance of its recognition. Here, a case of a dendritic fibromyxolipoma of the pyriform sinus in a 38-year-old male who presented with dysphagia, change of voice, and stridor is reported...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28078156/undifferentiated-malignant-neoplasm-involving-parotid-and-thyroid-sampling-and-pax8-cross-reactivity-can-obscure-the-diagnosis-of-lymphoma
#6
Elizabeth W Hubbard, Laurentia Nodit, Stuart Van Meter
Poorly differentiated malignant neoplasia arising within the head and neck region may originate from diverse sources. We report a case of a cytologically undifferentiated malignant neoplasm clinically presenting as masses involving thyroid and parotid. Although PAX8 was immunoreactive and thus worrisome for anaplastic thyroid carcinoma, the tumor was eventually proven to represent PAX5 positive diffuse large B-cell lymphoma expressing cross-reactivity with polyclonal PAX8 antibody. Cross-reactivity between commercially available polyclonal PAX8 and PAX5 immunostains has been described in the literature but is not widely known, and it is a potential pitfall for making a misdiagnosis...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28078155/lipomatous-hypertrophy-of-the-atrial-septum-in-a-patient-undergoing-coronary-artery-bypass-surgery
#7
Thomas Strecker, Michael Weyand, Abbas Agaimy
Background. Lipomatous hypertrophy of the atrial septum (LHAS) is a rare entity characterized by mass-forming deposition of fatty tissue within the atrial septum. To date, <300 cases have been reported; many of them were autopsy findings. The clinical presentation of LHAS varies from incidental asymptomatic mass (most frequent form) to severe life-threatening cardiovascular complications necessitating emergency cardiac surgery. Case Presentation. Here, we present the successful surgical resection of such a massive LHAS which was found incidentally on preoperative investigation of a 71-year-old patient with progressive coronary heart disease...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28053797/oral-intravascular-papillary-endothelial-hyperplasia-associated-with-an-organizing-thrombus-case-report-and-immunohistochemical-analysis
#8
Darcy Fernandes, Daphine Caxias Travassos, Túlio Morandin Ferrisse, Elaine Maria Sgavioli Massucato, Cláudia Maria Navarro, Mirian Aparecida Onofre, Jorge Esquiche León, Andreia Bufalino
Intravascular papillary endothelial hyperplasia (IPEH) is a benign lesion of the skin and mucosa of vascular origin characterized by reactive proliferation of endothelial cells. A 76-year-old woman was referred presenting a painless nodule on the lip. Intraoral examination revealed bluish submucosal nodular proliferation, measuring 10 × 5 × 5 mm, affecting the lower labial mucosa. The lesion had a firm consistency and it was not fixed to the adjacent tissues. The main differential diagnoses were mucocele/mucus retention cyst, sialolith, or salivary gland neoplasia...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28050299/polypoid-carcinoma-of-the-oropharynx-with-stromal-ossifying-myofibroblastic-proliferation-a-case-report-and-literature-review
#9
Marcello Filotico, Alessandro D'Amuri
A 76-year-old man reported a worsening difficulty in swallowing, leading to the inability to eat. Physical examination and CT scan revealed a polypoid mass on the posterior oropharynx and obstructing the oropharyngeal space. Histologically, the surface was ulcerated. In the underlying necrotic rim, there was active granulation tissue, and a proliferation of voluminous, globoid elements with hyperchromatic and irregular nucleus, sometimes arranged in a alveolar aggregate. The core of the lesion contained spindle-like myoid elements in interwoven bundles, with trabeculae of osteoid matrix maturing into calcified bone...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/28003924/intrathyroidal-clear-cell-tumor-of-parathyroid-origin-with-review-of-literature
#10
Daniela Pirela, Daniela Treitl, Siba El Hussein, Robert Poppiti, Thomas Mesko, Alex Manzano
Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Fine needle aspiration biopsy of the nodule revealed thyroid follicular cells without atypia and subsequent Afirma® Gene Expression Classifier (GEC) testing results were suspicious for malignancy...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27999702/serous-cystadenocarcinoma-arising-in-presumed-vitelline-duct-remnant-a-case-report-and-implications-in-the-management-of-cancer-of-unknown-primary
#11
Li Lei, Jeremy K Deisch
Background. Malignant neoplasms arising in Meckel's diverticulum, a vitelline duct remnant, are rare yet well-documented. Case Presentation. A 53-year-old previously healthy female presented with an enlarging midline abdominal wall mass. A computed tomography scan revealed a mass involving the linea alba, bilateral rectus abdominis, and subcutaneous fat. Extensive clinical workup failed to demonstrate other lesions, except local and paratracheal/hilar lymphadenopathy. Histopathologic examination of the resected tumor demonstrated a spectrum of serous neoplasia including serous cystadenoma, papillary serous carcinoma with numerous Psammoma bodies, and a poorly differentiated component...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27994902/gastric-adenocarcinoma-of-the-fundic-gland-type-treated-by-endoscopic-mucosal-resection-a-case-report-and-review-of-the-literature
#12
Eleanor Lewin, Philip Daroca, Sanjay Sikka, Tong Wu, Yukihiro Nakanishi
Gastric adenocarcinoma of the fundic gland type (GA-FG) is a rare entity that has only recently been described and defined. There is ongoing controversy regarding the malignant potential of this lesion. We report the case of a GA-FG in a 49-year-old Caucasian man who was referred to endoscopy for management of an incidentally found gastric polyp. Endoscopy showed a single polypoid lesion in the gastric fundus which was successfully removed with endoscopic resection. Grossly, the polyp measured 1.1 cm in greatest dimension...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27965908/a-previously-undescribed-presentation-of-mixed-adenoneuroendocrine-carcinoma
#13
Javier De Luca-Johnson, Maryam Zenali
We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a 1.8-cm gastric lesion, diagnosed as WD-NET (intermediate grade) on the biopsy. The resection specimen contained residual WD-NET; there was also a gastric adenoma adjacent to the NET and nodal metastasis with both adeno- and neuroendocrine components...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27957372/nephroblastoma-arising-from-primary-testicular-germ-cell-tumor-a-case-report-and-literature-review
#14
Houda Alatassi, Brittany E O'Bryan, Jamie C Messer, Zhenglong Wang
Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature. We report a case of a 19-year-old man who presented with a large right testicle. Image studies showed a large retroperitoneal mass along with liver and lung metastases. Orchiectomy demonstrated a mixed germ cell tumor composed of yolk sac tumor, embryonal carcinoma, and mature and immature teratoma with a significant portion of nephroblastoma...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27957371/a-rare-cause-of-nasal-obstruction-metastatic-renal-cell-carcinoma
#15
Tuba Dilay Kokenek-Unal, B Gumuskaya, B Ocal, Murat Alper
Introduction. Renal cell carcinoma can present with several interesting symptoms, paraneoplastic syndromes, and unusual metastatic sites. Head and neck region is one of the rare locations for renal cell carcinoma metastasis. Case Report. A 50-year-old man was admitted to the hospital with nasal congestion and snoring. Physical examination revealed nasal serous secretion. First taken biopsy was misinterpreted. The symptoms of the patient were not revealed and he was readmitted to the hospital. On radiologic examination, a vascular rich mass in maxillary sinus extending to the nasal cavity was observed...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27872782/angiosarcoma-arising-in-ovarian-mucinous-tumor-a-challenge-in-intraoperative-frozen-section-diagnosis
#16
Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Tip Pongsuvareeyakul, Sumalee Siriaunkgul
Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. A 45-year-old woman presented with an abdominal mass for 1 month. Exploratory laparotomy was performed. A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27872781/two-invasive-thymomas-incidentally-found-during-coronary-artery-bypass-graft-surgery
#17
Navid Omidifar, Maral Mokhtari, Mansoureh Shokripour
Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG) surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27847666/lipid-histiocytosis-of-the-gallbladder-neck-lymph-node
#18
Adriana Handra-Luca, Mohamed Habib Ben Romdhane, Beate Katharina Straub
Lipid histiocytosis of the gallbladder neck lymph node is rarely reported nowadays. Two obese patients presented with gallbladder lithiasis detected on CT scan. The treatment consisted in coelioscopic cholecystectomy. Microscopy revealed subacute/chronic lithiasic cholecystitis and foci of vacuolated cells in the gallbladder neck lymph node. These cells were positive for CD68, CD31, S100 protein, and adipophilin and negative for cytokeratin and Alcian blue. In conclusion, we report lymph node lipid histiocytosis diagnosed microscopically after cholecystectomy...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27840759/primary-neuroendocrine-carcinoma-of-the-breast-histopathological-criteria-prognostic-factors-and-review-of-the-literature
#19
Lena Marinova, Doroteya Malinova, Snezhinka Vicheva
We present here a case of a 42-year-old woman diagnosed with primary neuroendocrine carcinoma of the breast (NECB). We discuss the importance of histological criteria for primary neuroendocrine mammary carcinoma, established by WHO in 2003 and 2012. After an overview of different cases of primary neuroendocrine carcinoma of the breast published in the literature, we present information about differential diagnosis, prognostic factors, and surgical and adjuvant treatment. Prognosis of NECB is not different from that of other invasive breast carcinomas and the most important prognostic factor is tumor grade (G)...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27833772/adenomatous-polyps-in-adolescent-girl-and-boy-a-report-of-two-cases
#20
Laleh Vahedi Larijani, Maryam Ghasemi, Hassan Karami
A polyp is defined as a mass of the mucosal surface that protrudes into the lumen of the gastrointestinal tract. Neoplastic epithelial polyps are classified histologically as either benign adenoma or malignant carcinoma. The colonic polyps that most commonly present in children occur sporadically and individually and are of the juvenile type; they are most frequently associated with painless rectal hemorrhage (which is the most common symptom). Adenomatous polyps are similar to other nontumoral polyps, and it is very rare for children to have symptoms other than rectal bleeding...
2016: Case Reports in Pathology
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