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Case Reports in Pathology

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https://www.readbyqxmd.com/read/28929004/intraocular-plasmablastic-lymphoma-in-a-hiv-patient
#1
Carolline Fontes Alves Mariano, Glauce Lunardelli Trevisan, Antonio Augusto Velasco E Cruz, Fernando Chahud
Plasmablastic lymphoma (PBL) is a rare B-cell lymphoma occurring mainly in HIV patients. The tumor frequently involves extranodal sites such as the oral cavity, nasal cavity, gastrointestinal tract, skin, and lungs. The neoplastic cells are characterized by a plasmablastic appearance and typical immunophenotype that indicates plasma cell differentiation. Herein, we report a case of intraocular involvement by plasmablastic lymphoma in a HIV patient with a long history of cytomegalovirus retinitis and loss of vision...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28900550/bilateral-mesenchymal-hamartoma-of-the-chest-wall-in-a-3-month-old-boy-a-case-report-and-review-of-the-literature
#2
Mona Alfaraidi, Hossam Alaradati, Irfan Mamoun, Shamayel Mohammed
Mesenchymal hamartoma of the chest wall is a well-recognized but extremely rare entity. This entity is believed to be benign with no propensity for invasion or metastasis. Although the lesion manifests with alarming aggressive clinical, radiological, and histological features, it is considered benign and carries an excellent outcome. Therefore it is important to recognize this benign entity to avoid the possible misdiagnosis of malignancy and the unnecessary use of chemotherapy. We present a case of bilateral multifocal mesenchymal hamartomas of the chest wall in a male infant and a literature review of this entity...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28894617/idiopathic-myointimal-hyperplasia-of-mesenteric-veins-of-the-ileum-and-colon-in-a-patient-with-crohn-s-disease-a-case-report-and-brief-review-of-the-literature
#3
Sharon J Song, Stuti G Shroff
Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare disease characterized by intimal smooth muscle proliferation, leading to the thickening of small to medium-sized mesenteric veins. This vascular disease mimics inflammatory bowel disease (IBD) clinically and endoscopically, while showing ischemic mucosal changes without the classic features of IBD on biopsy. Given the mixed picture, this entity is frequently misdiagnosed. Surgical resection of the diseased bowel segment reveals the true etiology of the pathology and is curative...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28894616/esophageal-squamous-cell-carcinoma-presenting-with-streptococcus-intermedius-cerebral-abscess
#4
Rabih Nayfe, Mustafa S Ascha, Esther H Rehmus
BACKGROUND: Cerebral abscess is caused by inoculation of an organism into the brain parenchyma from a site distant from the central nervous system. Streptococcus intermedius (S. intermedius) is a commensal organism that is normally present in the aerodigestive tract and was reported to be the cause of brain abscesses after esophageal dilatation or upper endoscopy. CASE PRESENTATION: We report the case of a 53-year-old female who presented with hematemesis and melena followed by left-sided weakness...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28890838/adenocarcinoma-ex-goblet-cell-carcinoid-of-appendix-two-case-reports
#5
Yu-Ting Wang, Yi-Ru Li, Tuan-Ying Ke
Adenocarcinoma ex goblet cell carcinoid is a rare tumor incidentally found in specimens of appendicitis. Most patients present with acute abdomen, similar to acute appendicitis. Here we present two cases, which were found incidentally after operation. We give a brief summary about clinical and biological behavior of this entity.
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28852578/calciphylaxis-of-the-postmenopausal-female-breast-an-uncommonly-encountered-mimic-of-carcinoma
#6
Aaron G Novotny, Ashley B Simpson, Melinda A Kral, Benjamin C Calhoun, Amy E Cocco, Steven D Billings, Susan K Miller, Paulette L Lebda, Charles D Sturgis
Calciphylaxis is a serious medical condition that is typically associated with end-stage renal disease and presents as the sequelae of calcifications in arterioles with subsequent ischemia of affected tissues. Classically, calciphylaxis produces ulcerated and necrotic skin lesions. These may be biopsied to aid in confirmation of the diagnosis. Herein we report a case of a large necrotic breast lesion in the clinical setting of calciphylaxis, and we emphasize that a multidisciplinary approach to diagnosis and management is important to avoid unnecessary oncological resection...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28848684/a-rare-case-of-cutaneous-plasmacytosis-in-a-korean-male
#7
Corey Georgesen, Meenal Kheterpal, Melissa Pulitzer
Cutaneous and systemic plasmacytosis are reactive disease processes that occur in middle-aged Japanese and Chinese men. Systemic plasmacytosis, defined by plasmacytic infiltration of two organ systems, might rarely progress to lymphoma. Cutaneous plasmacytosis, however, is chronic and benign and is characterized by the development of multiple plasma cell-rich infiltrates in the skin. We present a case of cutaneous plasmacytosis in a 46-year-old Korean male. The patient demonstrated classic features of the disease entity, including disseminated red-brown plaques, differentiated plasmacytoid infiltrates on biopsy, hypergammaglobulinemia, and the absence of systemic disease...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28840050/gastric-medullary-carcinoma-with-sporadic-mismatch-repair-deficiency-and-a-tp53-r273c-mutation-an-unusual-case-with-wild-type-braf
#8
Brett M Lowenthal, Theresa W Chan, John A Thorson, Kaitlyn J Kelly, Thomas J Savides, Mark A Valasek
Medullary carcinoma has long been recognized as a subtype of colorectal cancer associated with microsatellite instability and Lynch syndrome. Gastric medullary carcinoma is a very rare neoplasm. We report a 67-year-old male who presented with a solitary gastric mass. Total gastrectomy revealed a well-demarcated, poorly differentiated carcinoma with an organoid growth pattern, pushing borders, and abundant peritumoral lymphocytic response. The prior cytology was cellular with immunohistochemical panel consistent with upper gastrointestinal/pancreaticobiliary origin...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28785500/pulse-granulomas-of-the-gastrointestinal-tract-and-gallbladder-report-of-five-cases
#9
Tom C DeRoche, Gregory A Gates, Aaron R Huber
Hyaline rings with admixed multinucleated giant cells characterize pulse granulomas; the term pulse refers to edible seeds of legume vegetables. The etiology has been controversial, with theories including vascular degenerative changes or a reaction to vegetable material; ultrastructural studies and experimentally induced lesions in animals favor the latter. This lesion is typically seen in the oral cavity, with only rare reports in the gastrointestinal tract and gallbladder. We herein describe five cases of pulse granulomas identified in these sites...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28751996/leiomyosarcoma-and-squamous-cell-carcinoma-arising-in-mature-cystic-teratoma-of-the-ovary
#10
Tip Pongsuvareeyakul, Kornkanok Sukpan, Somjet Chaicharoen, Surapan Khunamornpong
The occurrence of malignant transformation in mature cystic teratoma of the ovary is rare, with squamous cell carcinoma being the most common histologic type. Sarcomatous transformation has been rarely described in the literature. We present a case of leiomyosarcoma with a minor component of squamous cell carcinoma arising in mature cystic teratoma of ovary in a 65-year-old woman. The malignant tumor showed two distinct components of sarcomatous and invasive epithelial elements, which were confirmed by immunostaining...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28698815/glomangioma-of-the-kidney-a-rare-case-of-glomus-tumor-and-review-of-the-literature
#11
Ammar Almaghrabi, Nizar Almaghrabi, Haneen Al-Maghrabi
BACKGROUND: Glomus tumors are rare mesenchymal tumors originating from glomus bodies in the skin. Glomus tumors of the kidney are rare tumors and only a few cases have been reported in the medical literature. An extensive search revealed a very limited number of primary renal glomus tumors. Although most of these cases were benign in nature, including a case with uncertain diagnosis of malignant potential, two were malignant. CASE REPORT: We present a unique case of a 57-year-old male patient with an incidentally discovered 2 cm left renal mass...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28634564/pax8-distinguishes-diffuse-large-b-cell-lymphoma-mimicking-sarcoma
#12
Michelle S Hirsch, Alessandra F Nascimento
PAX8 is important for embryogenesis of the thyroid, Müllerian system, and upper urinary/renal tract, and expression of PAX8 has been described in carcinomas from each of these sites. The sensitivity and specificity of the polyclonal PAX8 antibody in a large cohort of epithelial tumors as well as lymphomas have been previously determined, the latter because polyclonal PAX8 is known to be immunoreactive in nonneoplastic B-cell lymphocytes which are often used as the positive internal control for immunohistochemistry...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28626594/a-case-report-gastric-mixed-neuroendocrine-nonneuroendocrine-neoplasm-with-aggressive-neuroendocrine-component
#13
Quang Duy Pham, Ichiro Mori, Robert Y Osamura
Mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) is defined as mixed epithelial neoplasms composed of both neuroendocrine and nonneuroendocrine components with variable proportions for each component. Neuroendocrine component can show morphological features including well- or poorly differentiated neuroendocrine neoplasms and nonneuroendocrine component can present different tumor types depending on the site of origin. Recently, studies of tumors have shown that MiNENs are not as rare as our traditional belief, due to the wide application for immunohistochemistry...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28626593/langerhans-cell-sarcoma-a-case-report-demonstrating-morphological-and-immunophenotypical-variability-within-a-single-lesion
#14
Rasika Singh, Charles Edward Keen, Christopher Stone, Patrick Sarsfield
Langerhans cells are antigen presenting dendritic cells and tumours arising from these are rare. The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and Langerhans cell sarcoma. It is the degree of atypia and clinical aggressiveness that distinguishes the two subtypes. Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells which can occur in skin, bone marrow, lymph nodes, spleen, liver, and lung...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28620558/primary-renal-carcinoid-with-bilateral-multiple-clear-cell-papillary-renal-cell-carcinomas
#15
Daniel A Anderson, Maria S Tretiakova
Clear cell papillary renal cell carcinoma (CCPRCC) is a newly recognized entity in the 2016 WHO classification and usually presents as a small, circumscribed, solitary mass of indolent nature. CCPRCCs could seldom occur in conjunction with other synchronous or metachronous kidney tumors and even less frequently as bilateral masses. To our knowledge, multiple bilateral CCPRCCs have never been described with the existence of a synchronous well-differentiated neuroendocrine tumor of the kidney and hence reported here as a unique case...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28607791/benign-multicystic-peritoneal-mesothelioma-a-rare-condition-in-an-uncommon-gender
#16
Muhammad S Khurram, Hamadullah Shaikh, Uqba Khan, Jacob Edens, Warda Ibrar, Ameer Hamza, Awais Zaka, Roohi Bano, Tarik Hadid
Benign Multicystic Peritoneal Mesothelioma (BMPM) is a rare condition that arises from the abdominal peritoneum. Fewer than 200 cases have been reported worldwide. BMPM usually affects premenopausal women and is extremely rare in men. Many factors are suspected to contribute to its development, such as previous surgery, endometriosis, and familial Mediterranean fever. The main management is surgical resection; however, it is estimated that the recurrence rate is up to 50%. Malignant transformation is rare. We report a case series of three male patients who were diagnosed with BMPM and were treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28607790/sporadic-retroperitoneal-hemangioblastoma-report-of-a-case-and-review-of-the-literature
#17
F G Jalikis, B L Hoch, R Bakthavatsalam, M I Montenovo
We report a case of sporadic isolated hemangioblastoma arising from the retroperitoneum and provide a review of the scarce literature regarding this very rare tumor. Furthermore, we thoroughly describe the pathologic features and the broad differential diagnosis that should always be included in the study of any retroperitoneal soft tissue mass to arrive at the final diagnosis.
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28584672/keratoacanthoma-of-the-nasal-septum-secondary-to-ranibizumab-use
#18
Jason E Cohn, Hilary M Caruso Sales, Giang Huong Nguyen, Harvey Spector, Kenneth Briskin
Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater. KA is considered to be a low-grade variant of squamous cell carcinoma (SCC). We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use. A flesh-colored lesion on the right anterior nasal septum lesion was visualized on examination. Histologic examination revealed a well-circumscribed, dome-shaped central crater filled with keratin, well-differentiated squamous epithelium with ground-glass cytoplasm with pushing margins, and intraepithelial microabscesses establishing the diagnosis of KA...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28584671/hybrid-desmoplastic-follicular-ameloblastoma-of-the-mandible-a-case-report-and-review-of-the-literature
#19
Masayasu Iwase, Airi Fukuoka, Yoko Tanaka, Naoyuki Saida, Eriko Onaka, Sanae Bando, Gen Kondo
Desmoplastic ameloblastoma (DA) is one of the 6 histopathological subtypes of ameloblastoma. Hybrid lesions in which histopathologically conventional ameloblastoma coexists with areas of DA are rare. A 40-year-old male was referred to our hospital complaining of a swelling in the right premolar region of the mandible. A panoramic radiograph showed an area of radiolucency with a well-defined corticated border, whereas computed tomography revealed a unilocular radiolucent lesion and buccal expansion together with cortical perforation...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28555169/strongyloides-colitis-as-a-harmful-mimicker-of-inflammatory-bowel-disease
#20
Julio Poveda, Farah El-Sharkawy, Leopoldo R Arosemena, Monica T Garcia-Buitrago, Claudia P Rojas
Autoinfection caused by Strongyloides stercoralis frequently becomes a life-long disease unless it is effectively treated. There is overlapping histomorphology between Strongyloides colitis and inflammatory bowel disease; a low index of suspicion can lead to misdiagnosis and fatal consequences. We present a case of Strongyloides colitis mimicking the clinical and pathologic features of inflammatory bowel disease. A 64-year-old female presented to the emergency department with a four-day history of abdominal pain, diarrhea, and hematochezia...
2017: Case Reports in Pathology
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