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Danish Medical Journal

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https://www.readbyqxmd.com/read/29726321/correction-to-quality-assessment-of-home-births-in-denmark
#1
Sabrina Jensen, Lotte B Colmorn, Anne-Mette Schroll, Lone Krebs
Correction per 30 April 2018. In a letter from Ole Olsen et al [1] it was disclosed, that there were mathematical errors in the incidences of complications among nulliparous women with hospital births presented in Table 2. Incidences and p-values have been recalculated, and the errors in Table 2 have been corrected. We apologise for this. The corrections did not lead to any other changes in the manuscript [1].
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29726320/preferences-for-prenatal-testing-among-pregnant-women-partners-and-health-professionals
#2
Ida Charlotte Bay Lund, Naja Becher, Olav Bjørn Petersen, Melissa Hill, Lyn Chitty, Ida Vogel
INTRODUCTION: Cell-free DNA testing (cfDNA testing) in maternal plasma has recently been implemented in Danish healthcare. Prior to that we wanted to evaluate the preferences among pregnant women, partners and health professionals regarding cfDNA testing compared with invasive prenatal diagnostics. METHODS: Responders were recruited at public hospitals in the Central and North Denmark Regions. Stated preferences for prenatal testing were obtained through an online questionnaire incorporating a discrete choice experiment...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29726319/safety-and-feasibility-of-home-based-chemotherapy
#3
Finn Ole Larsen, Anne Birgitte Christiansen, Anette Rishøj, Knud Mejer Nelausen, Dorte L Nielsen
INTRODUCTION: The purpose of this study was to evaluate the safety and feasibility of home-based chemotherapy and to compare chemotherapy given at home with chemotherapy given as an outpatient treatment in relation to toxicity, quality of life and patient's preference. METHODS: Patients who had undergone radical surgery for colon cancer and who were eligible to receive adjuvant treatment with capecitabine and oxaliplatin could be included. To ensure patient safety, the first infusion was given at an outpatient clinic...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29726318/the-use-of-olfactory-testing-when-diagnosing-parkinson-s-disease-a-systematic-review
#4
Tine Nielsen, Martin Bang Jensen, Egon Stenager, Andreas Dammann Andersen
INTRODUCTION: The diagnosis of Parkinson's disease (PD) is typically based on the presence of motor symptoms, but in the early phase of the disease, the diagnostic process can be challenging. Examination of non-motor symptoms in patients suspected of PD has gained growing attention. Olfactory tests have shown promising results as ancillary diagnostic tests. The aim of this study was to investigate how olfactory tests may be used clinically in diagnostic process in PD. METHODS: A systematic search was conducted in PubMed for relevant literature on 8 March 2017...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29726317/anaesthesia-practice-in-denmark-for-relocation-of-the-dislocated-hip-after-total-hip-arthroplasty
#5
Christine P Holler, Nicolai Lohse, Nicolai B Foss
INTRODUCTION: The prevalence of hip dislocations after total hip arthroplasty (THA) is 2-4% in Denmark. Patients with a dislocated THA are often elderly citizens with comorbidities and severe pain in the pre-reposition phase. Evidence as to which method of anaesthesia and airway management is best for hip relocation is lacking. The aim of this study was to determine how anaesthesiologists in Denmark provide anaesthesia for relocation of THAs, and if a local guideline is available. METHODS: A questionnaire was distributed by e-mail to all members of the Danish Association of Anaesthesiology and Intensive Care and the Danish Society of Young Anaesthesiologists...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29726316/correlation-of-radiological-and-clinical-measurement-of-genu-valgum-in-children
#6
Nina Hardgrib, Martin Gottliebsen, Ole Rahbek, Michel Bach Hellfritzsch, Bjarne Møller-Madsen
INTRODUCTION: Genu valgus is a condition characterised by a lateral shift of the knee's mechanical axis. The deformity can be characterised using clinical examinations and long hip-knee-ankle (HKA) angles, but it is unclear how these investigations correlate with each other. Our aim was to examine the correlation between clinical and radiographic measurements of the lower extremities in children. METHODS: A total of 49 children between 5.9 and 16.7 years of age who had been referred with genu valgum deformity were included...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29726315/the-risk-of-skin-tear-in-dupuytren-s-disease-when-treated-with-collagenase
#7
Christian Fagernæs, Susanne Mallet
INTRODUCTION: The purpose of this study was to explore if there was a correlation between joint level and degree of contracture on the one hand and the risk of skin tear in Dupuytren's disease (DD) on the other, when treated with collagenase from Clostridium histolyticum. No trial or study has explored the risk of skin tear as primary outcome in a population that has not been treated for DD before. METHODS: A retrospective study of prospectively collected data was performed on patients with DD treated with collagenase from 1 August 2012 to 1 April 2014...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619938/sunscreen-use-at-danish-beaches-and-how-to-improve-coverage
#8
Ida M Heerfordt
Exposure to ultraviolet radiation (UVR) from the sun is the main risk factor for development of skin cancer. The incidence of skin cancer in Denmark and worldwide is high and increasing. The overall aim was to achieve basic knowledge about sun protection with sunscreen among beachgoers in Denmark. Other aims were to establish a method to investigate sunscreen distribution on the body and to test two approaches to optimize the used amount and body distribution of sunscreen. Furthermore, time and duration of a beach visit and use of protective clothes among beachgoers were determined to investigate the risk the beachgoers expose themselves to...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619937/the-impact-of-surgery-on-quality-of-life-esophageal-motility-and-tracheal-anatomy-and-airflow-in-patients-with-benign-nodular-goiter
#9
Jesper Roed Sorensen
Surgery - is it any good for goiter? In patients with goiter the benefits of thyroid surgery have previously rarely been investigated, as only few alternatives existed. However, the increasing evidence of the advantages with non-surgical substitutes with lower costs and preferable risk profiles prompted us to investi-gate the evidence base for thyroid surgery thoroughly. This thesis consists of three published studies investigating the impact of thyroidectomy on: 1) changes in disease-specific quality of life, 2) swallowing symptoms and esophageal motility, and 3) tracheal anatomy and airflow, in a cohort of patients with benign nodular goiter...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619936/intravenous-iron-treatment-in-the-puerperium
#10
Charlotte Holm
Iron deficiency and anaemia in the puerperium are associated with several important clinical consequences, most prominently physical fatigue. Current treatment practice with oral iron supplementation is associated with gastrointestinal side-effects and subsequent poor compliance. Red blood cell transfusion is also widely used to treat severe postpartum anaemia, though accumulating evidence questions its risk-benefit ratio. Intravenous iron has in previous studies been associated with fast improvement of haemoglobin and iron biochemical markers in the treatment of postpartum anaemia, but there is a lack of studies on patient reported outcomes...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619935/tourette-syndrome-in-a-longitudinal-perspective-clinical-course-of-tics-and-comorbidities-coexisting-psychopathologies-phenotypes-and-predictors
#11
Camilla Groth
Tourette syndrome (TS) is a childhood onset neurodevelopmental disorder characterised by motor and vocal tics and frequent associated comorbidities. The developmental trajectory of tic shows tic-onset in the age of 4-6, peak in the age of 10-12 and decline during adolescence, although only few and small longitudinal studies form the basis of this evidence. Recent studies suggest that comorbid obsessive-compulsive disorder (OCD), attention deficit-hyperactivity disorder (ADHD) and coexisting psychopathologies tend to persist and become more dominant in adolescence...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619934/assessing-synovitis-with-conventional-static-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-knee-osteoarthritis
#12
Robert Gc Riis
Knee osteoarthritis (KOA) is one of the most common causes of physical disability in the elderly population. With an increasing ageing and obese population, the prevalence of KOA is expected to rise substantially. The needs for a better understanding of the disease and tools that can predict the course of the disease, for example following treatment, are therefore imperative. 

Inflammation has over the last years been recognised as an important factor for both the symptomatology and disease course in KOA...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619933/monitoring-ovarian-cancer-patients-during-chemotherapy-and-follow-up-with-the-serum-tumor-marker-ca125
#13
Suher Othman Abu Hassaan
Cancer antigen 125 (CA125) is frequently used in the routine monitoring of patients with epithelial ovarian cancer (EOC). The potential benefit is based on the assumption that changes in serial concentrations may provide early and reliable information on tumor growth expediting an early and potentially effective treatment. However, it has remained a challenge to interpret increments in concentrations that correlate with increasing tumor burden in the individual patient. It has been hypothesized that CA125 assessment criteria taking the random variation (analytical and biological) into account may have better accuracy and lead-time potential than criteria based only on an arbitrary percentage of increase...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619932/mortality-and-morbidity-in-patients-with-osteogenesis-imperfecta-in-denmark
#14
Lars Folkestad
Ostegenesis imperfecta (OI) is a hereditary disease of the connective tissue caused by mutations to, mainly, the genes that are involved in the biosynthesis of collagen type 1. Patients are grouped according to clinical severity and mode of inheritance according to Sillence's classification (originally 1979, updated 2014). According to our data, the population prevalence of OI in Denmark was 10.3 per 100,000, with 575 patients registered with an OI diagnosis in the National Patient Register and alive at the end of 2012 out of a total population of 5,602,628 persons...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619931/approaches-to-radiotherapy-in-metastatic-spinal-cord-compression
#15
Morten Hiul Suppl
Metastatic spinal cord compression is caused by the progression of metastatic lesions within the vicinity of the spinal cord. The consequences are very severe with loss of neurological function and severe pain. The standard treatment is surgical intervention followed by radiotherapy or radiotherapy alone. However, the majority of patients are treated with radiotherapy only due to contraindications to surgery and technical inoperability. Stereotactic body radiotherapy is a technology to deliver higher radiation dose to the radiotherapy target with the use of spatial coordinates...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619930/neurological-and-psychiatric-comorbidity-in-patients-with-heart-failure-risk-and-prognosis
#16
Kasper Adelborg
Heart failure is a complex clinical syndrome and one of the leading causes of morbidity and mortality with a prevalence of 1%-2% of the adult population. The prognosis is poor with a 5-year mortality rate of 50%, which partly can be attributed to the presence of concomitant comorbidity, including neurological and psychiatric comorbidities. However, the prognostic impact of depression and the role of heart failure as a risk factor for dementia and stroke are not fully understood.
 Denmark is well-known for its unique health registries...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619929/depression-stroke-and-dementia-in-patients-with-myocardial-infarction
#17
Jens Sundbøll
The connection between the heart and mind has been studied since Sir William Harvey observed more than 350 years ago that negative emotions adversely affect the heart. Today, we know that diseases of the mind can affect the heart and, conversely, that heart diseases can cause both physical and mental diseases of the brain. To explore this relation further, we examined how previous depression affects survival in patients with myocardial infarction (MI) (study II), and how the occurrence of MI affects the risk of ischemic and hemorrhagic stroke (study III) and dementia (study IV)...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619928/studies-of-upper-limb-pain-in-occupational-medicine-in-general-practice-and-among-computer-operators
#18
Jørgen Riis Jepsen
Diagnostic consensus criteria cannot be applied in a major proportion of patients with upper limb complaints, many of which are regarded as "non-specific". The three empirical studies in this thesis aimed to address this diagnostic challenge by incorporating representative neurological qualities in the physical examination.
Patterns of muscle weakness, sensory abnormalities and nerve trunk allodynia based on the nerves' topography and their motor and cutaneous innervation were defined to reflect peripheral nerve afflictions and their locations...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619927/joinpoint-regression-analysis-of-suicides-in-denmark-during-1980-2015
#19
Susanne Mahmood Dyvesether, Merete Nordentoft, Julie Lyng Forman, Annette Erlangsen
INTRODUCTION: Major advances have been achieved in suicide prevention over the past decades. Effective suicide prevention requires vigilant monitoring of suicide trends. The aim of this study was to assess the change in the Danish suicide rate over time using joinpoint regression analysis and to examine the distribution of suicide methods in the 1980-2015 period. METHODS: Nationwide register data were obtained from the Central Research Register and the Danish Cause of Death Register...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619926/parenteral-nutrition-and-insulin-per-protocol-improve-diabetes-management-after-total-pancreatectomy
#20
Sakshi Andersen, Andreas Andersen, Lene Ringholm, Carsten Palnæs Hansen, Jan Storkholm, Kerstin Lillpers, Charlotte Schiøtz, Elisabeth Reinhardt Mathiesen
INTRODUCTION: Pancreatogenic diabetes develops in patients undergoing total pancreatectomy and complicates post-surgical management. The aim of this study was to compare parenteral nutrition (PN) with protocolled insulin treatment to intravenous glucose treatment after total pancreatectomy. METHODS: This was a retrospective study of 97 patients undergoing total pancreatectomy between 2009 and 2014. Patients were divided into a PN cohort (n = 57) and a glucose cohort (n = 40)...
April 2018: Danish Medical Journal
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