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Danish Medical Journal

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https://www.readbyqxmd.com/read/28874246/early-onset-coronary-artery-disease-clinical-and-hereditary-aspects
#1
Morten Krogh Christiansen
A family history of coronary artery disease (CAD) is an important risk factor for adverse coronary events, in particular if the disease has an early onset. The risk of CAD is influenced by genetic and environmental factors with a greater genetic contribution earlier in life. Through recent years the advances in genetic techniques has led to an increased understanding of the genetic background of CAD, which may potentially be translated into clinical use. The studies of this thesis aimed to investigate the burden of conventional risk factors and control in early-onset CAD (i...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28874245/prosthetic-joint-infection-following-total-hip-arthroplasty-incidence-mortality-and-validation-of-the-diagnosis-in-the-danish-hip-arthroplasty-register
#2
Per Hviid Gundtoft
Prosthetic joint infection (PJI) is a rare, but devastating complication following primary total hip arthroplasty (THA). As PJI is a rare event, large cohorts of patients are required in order to study this complication. National arthroplasty registers offer such large and unselected cohorts, but studies have shown that these registers - used alone - underestimate the incidence of PJI. The aim of this thesis was to estimate the incidence of PJI and the mortality risk following a PJI by combining data from the Danish Hip Arthroplasty Register (DHR), the National Register of Patients (NRP), the Microbiology Databases, the Civil Registration System, the medical records, the Danish National Prescription Registry and the Clinical Biochemistry Databases...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28874244/the-interplay-between-fasting-glucose-echocardiography-and-biomarkers-pathophysiological-considerations-and-prognostic-implications
#3
Manan Pareek
BACKGROUND: Traditional cardiovascular risk stratification tools that employ clinical risk factors are limited by their modest discriminative abilities. As such, robust cardiovascular risk assessment, including our understanding of the complex interplay between risk factors, in the primary preventive setting, remains incomplete. Phenotypical heterogeneity may be even greater among subjects with hyperglycemic conditions, i.e., prediabetes and diabetes, which is worrisome, given the dramatic global rise in mean fasting glucose levels, and the strong association with adverse cardiovascular outcomes...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28874243/central-regional-anaesthesia-in-patients-with-aortic-stenosis-a-systematic-review
#4
Sofia Johansson, Morten Nikolaj Lind
INTRODUCTION: Aortic stenosis is a valvular lesion that poses several haemodynamic challenges for the anaesthesiologist. The use of central regional anaesthesia is traditionally regarded as contraindicated in patients with severe aortic stenosis due to its sympatholytic effect, potentially causing loss of vascular tone and ultimately diminished cardiac output. The aim of this paper was to review current literature to find evidence for or against the use of neuroaxial blockade in patients with aortic stenosis...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28874242/effects-of-low-dose-recombinant-human-erythropoietin-treatment-on-cognitive-performance
#5
Søren Lundgaard Viuff, Ulla Plenge, Bo Belhage, Robert Boushel, Thomas Koester
INTRODUCTION: High-dose recombinant human erythropoietin (rhEpo) has been shown to improve cognitive performance in both healthy volunteers and in patients suffering from diseases affecting the brain. The aim of this study was to examine whether administration of low-dose and even micro-dose rhEpo improves cognitive performance in healthy volunteers. METHODS: We enrolled 25 healthy volunteers in a double-blind, randomised, placebo-controlled study to receive either low-dose rhEpo (n = 8, 60 IU/kg/week), micro-dose rhEpo (n = 9, 20 IU/kg/week), or saline (n = 8) for four weeks...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28874241/infant-botulism-in-denmark-from-1995-to-2015
#6
Bergitte Drivenes, Tyra Grove Krause, Mikael Andersson, Luise Müller, Kurt Fuursted, Tanja Pedersen, Anne Kirkeby Hansen, Malene Landbo Børresen
INTRODUCTION: Infant botulism is a rare, probably underdiagnosed, life-threatening disease caused by the toxin-producing bacterium Clostridium botulinum. METHODS: We investigated reported cases of infant botulism in Denmark from 1995 to 2015, and compared the incidence with that of other western countries. RESULTS: We found nine cases of infant botulism in Denmark from 1995 to 2015. The incidence of infant botulism in Denmark was similar to that seen in other western countries, but likely underestimated...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28869034/plasticity-and-function-of-human-skeletal-muscle-in-relation-to-disuse-and-rehabilitation-influence-of-ageing-and-surgery
#7
Charlotte Suetta
In order to study the influence of disuse and aging on skeletal muscle homeostasis, different human models were employed. Effects of chronic disuse were investigated in elderly patients suffering from uni-lateral hip-osteoarthritis, whereas the effect of short-term disuse (4 and 14 days of unilateral lower limb immobilisation) was assessed in healthy young and old individuals. In summary, chronic muscle disuse in the elderly was associated with marked quantitative as well as qualitative neuromuscular impairments...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28869033/life-course-of-children-with-parental-multiple-sclerosis
#8
Julie Yoon Moberg
BACKGROUND: The majority of persons with multiple sclerosis (MS) experience onset of MS between the ages of 20 and 40. Since two-thirds of the persons with MS are young women of childbearing age, parenthood is an essential issue during this period of life. The potential influence of parental MS on children arises from the varied symptoms of the chronic illness, which affect physical and cognitive abilities. MS disabilities and fatigue can restrict daily life and result in less energy for activities or job loss and thus worse conditions for the family...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28869032/tissue-engineering-as-an-adjunct-to-pelvic-reconstructive-surgery
#9
Hanna Jangö
This PhD-thesis is based on animal studies and comprises three original papers and unpublished data. The studies were con-ducted during my employment as a research fellow at the Department of Obstetrics and Gynecology, Herlev University Hospital, Denmark. New strategies for surgical reconstruction of pelvic organ pro-lapse (POP) are warranted. Traditional native tissue repair may be associated with poor long-term outcome and augmentation with permanent polypropylene meshes is associated with frequent and severe adverse effects...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28869031/cost-analysis-of-bariatric-surgery-in-denmark-made-with-a-decision-analytic-model
#10
Oleg Borisenko, Vasily Lukyanov, Søren Paaske Johnsen, Peter Funch-Jensen
INTRODUCTION: Bariatric surgery offers effective obesity treatment. The aim of this study was to evaluate the cost-effectiveness of bariatric surgery in Denmark from a third-party payer perspective in the mid- (ten years) and long-term (lifetime). METHODS: A state-transition Markov model was developed in which patients may experience surgery, post-surgery complications, diabetes mellitus type 2, cardiovascular diseases or die. Transition probabilities, costs and utilities were informed by the literature...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28869030/use-of-coercion-at-danish-psychiatric-wards-by-day-of-week-and-time-of-day
#11
Susanne Mølgaard Leerbeck, Jan Mainz, Henrik Bøggild
INTRODUCTION: Mechanical restraint and other forms of coercion may be used under certain circumstances at psych-iatric wards. The use of coercion receives considerable focus, yet little is known about its diurnal distribution. We examined the initiation of mechanical restraint, sedative drug administration, physical retention, door locking and personal shielding by time of day and week. METHODS: Group 3 protocols in the national Register of Coercion for patients aged ≥ 18 years in the years 2010-2012 were analysed...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28869029/validation-of-the-danish-version-of-inflammatory-bowel-disease-self-assessment-scale
#12
Charlotte Vestergaard, Jens Frederik Dahlerup, Palle Bager
INTRODUCTION: The Inflammatory Bowel Disease Fatigue Self-assessment Scale (IBD-F) is a multidimensional, disease-specific questionnaire. Patients with inflammatory bowel disease (IBD) took part in the development of the tool. The scale was developed in the UK and comprises 35 questions: five questions about the severity of fatigue and 30 questions about the impact of fatigue. The purpose of this study was to validate a Danish electronic version of the IBD-F in a Danish IBD population...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673384/testosterone-therapy-of-men-with-type-2-diabetes-mellitus-a-randomized-double-blinded-placebo-controlled-study
#13
Line Velling Magnussen
The prevalence of chronic diseases including obesity and type 2 diabetes mellitus (T2D) are increasing. The usage of testosterone replacement therapy (TRT) has escalated in the Western countries during the past decades especially in aging men without clear organic indication for TRT although the safety of long-term TRT has not been clarified regarding the risk of cardiovascular disease (CVD). Aging men with T2D have an increased risk of CVD and these patients are often characterized by lowered T-levels, ectopic fat depots, a deranged adipokine profile with e...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673383/preoperative-embolization-in-surgical-treatment-of-metastatic-spinal-cord-compression
#14
Caroline Clausen
An increasing number of patients develop symptomatic spinal metastasis and increasing evidence supports the benefit of surgical decompression and spinal stabilization combined with radiation therapy. However, surgery for metastatic spinal disease is known to be associated with a risk of substantial intraoperative blood loss and perioperative allogenic blood transfusion. Anemia is known to increase morbidity and mortality in patients undergoing surgery, but studies also indicate that transfusion with allogenic red blood cells (RBC) may lead to worse outcomes...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673382/rational-use-of-dopamine-in-hypotensive-newborns-improving-our-understanding-of-the-effect-on-cerebral-autoregulation
#15
Vibeke Ramsgaard Eriksen
Hypotension in critically ill newborn infants is associated with higher mortality and higher risk of cerebral injuries. Yet treating hypotension has never been shown to improve outcomes. In fact, some studies have found that hypotensive newborn infants who were treated with dopamine fared worse than a comparable group of newborn infants who were not. Therefore, a concern has been raised that dopamine might cause the observed adverse outcomes. Cerebral autoregulation is a protective mechanism that maintains a fairly constant cerebral blood flow despite fluctuations in blood pressure...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673381/biomarkers-of-necrotising-soft-tissue-infections-aspects-of-the-innate-immune-response
#16
Marco Bo Hansen
Necrotising soft tissue infection (NSTI) is a life-threatening and rapidly progressing bacterial infection involving one or more layers of the soft tissue compartments causing necrosis. The amputation and mortality rates remain high despite increased focus on the patients. Timely treatment, including surgical intervention, reduces the risk of severe disability and death. However, the lack of pathognomonic signs impedes early diagnosis and treatment. Moreover, the rarity of the disease makes it difficult to conduct large prospective studies, thus prospective research is almost non-existent in this group of patients...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673380/possible-adverse-effects-of-the-quadrivalent-human-papillomavirus-vaccine-in-the-region-of-southern-denmark-a-retrospective-descriptive-cohort-study
#17
Cecilie Cramon, Christina Lindegaard Poulsen, Ulla Birgitte Hartling, Inge Kristine Holden, Isik Somuncu Johansen
INTRODUCTION: Since the introduction of the quadrivalent human papillomavirus vaccine, young girls and women have reported a broad range of symptoms. These have been described as possible adverse effects of the vaccine. In this study, we describe demographic characteristics, symptomatology, clinical and laboratory test results in patients referred with suspected adverse effects in the Region of Southern Denmark. METHODS: We conducted a retrospective, descriptive study...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673379/return-to-work-after-lumbar-disc-surgery-is-related-to-the-length-of-preoperative-sick-leave
#18
Mikkel Ø Andersen, Carsten Ernst, Jesper Rasmussen, Søren Dahl, Leah Y Carreon
INTRODUCTION: Lumbar disc herniation (LDH) is associated with high morbidity and significant socio-economic impact as the majority of the patients are of working age. The purpose of this study was to determine the impact of length of sick leave on the return-to-work rate after lumbar disc herniation surgery. METHODS: This was a single-centre study of LDH patients who underwent surgery from 18 May 2009 through 28 November 2014. Data were collected prospectively from the DaneSpine database...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673378/newly-diagnosed-obstructive-sleep-apnoea-and-type-2-diabetes-mellitus
#19
Anne Roed Jacobsen, Freja Eriksen, Line Thorup, Lykke Bennedsen Skødeberg, Jonas Peter Yde Holm, Klavs Wörgler Hansen
INTRODUCTION: Obstructive sleep apnoea (OSA) is frequent in type 2 diabetes mellitus (DM) and is seen in 12-30% of patients with newly diagnosed OSA according to previous studies. Our aim was to determine the referral pattern and prevalence of patients with self-reported type 2 DM in a Danish cohort of patients with newly diagnosed OSA. Furthermore, we compared clinical data related to the sleep disorder in patients with and without type 2 DM and different OSA severities. METHODS: This retrospective observational study was based on data from a cohort including all patients offered continuous positive airway pressure therapy in the course of a 14-month period after being referred to a sleep disorders clinic...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28673377/low-incidence-of-perineal-hernia-repair-after-abdominoperineal-resection-for-rectal-cancer
#20
Katarina Levic, Kasper von Rosen, Orhan Bulut, Thue Bisgaard
INTRODUCTION: Perineal hernia may be a long-term complication to conventional abdominoperineal resection or proctocolectomy. We analysed the incidence of post-operative perineal hernia repair and described patient-reported outcome measures (PROMS) after perineal hernia repair. METHODS: This was a nationwide retrospective analysis of consecutive Danish patients undergoing conventional abdominoperineal resection or proctocolectomy for rectal cancer from 1 January 2004 to 31 December 2014 combined with patients undergoing a subsequent repair for a perineal hernia during the follow-up period from 1 January 2004 to 31 December 2016...
July 2017: Danish Medical Journal
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