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Danish Medical Journal

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https://www.readbyqxmd.com/read/29115211/measurement-of-gastrointestinal-hormones
#1
Nicolai J Wewer Albrechtsen
Towards the end of the 20th century, the number of subjects with diabetes and obesity rose exponentially. The discoveries of insulin- and appetite-modulating chemical signals, including glucagon-like peptide-1 (GLP-1), secreted from the gastrointestinal system, led to development of a new group of drugs which now are being used for glucose-lowering therapy and weight loss. Understanding of the physiology of gut derived signals and their pathophysiologi-cal importance requires accurate measurements of their circulat-ing levels...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115210/surgeon-performed-ultrasonography
#2
Tobias Todsen
Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal and head & neck ultrasonography using the Objective Structured Assessment of Ultrasound Skills (OSAUS) scale. With the use of Messick's unitary framework of validity, five sources of validity evidence were explored: test content, response processes, inter-nal structure, relations to other variables, and consequences...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115209/exploring-the-use-of-ingenol-mebutate-to-prevent-non-melanoma-skin-cancer
#3
Andrés Már Erlendsson
Non-melanoma skin cancer is the most frequently occurring cancer in Caucasians today. Incidence rates in Europe have increased steadily since the 1960s and more than tripled over the last 50 years. Despite primary preventative efforts, incidences of non-melanoma skin cancer continue to rise and development of effective chemopreventative strategies is needed. In 2013, ingenol mebutate was approved in Denmark as a new topical drug for field-directed treatment for actinic keratoses. Ingenol mebutate has a dual mechanism of action, causing initial cell death, followed by an immune activation...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115208/prevalence-of-neovascular-age-related-macular-degeneration-and-geographic-atrophy-in-denmark
#4
Farnam Barati Sedeh, Daniel Andrew Richard Scott, Yousif Subhi, Torben Lykke Sørensen
INTRODUCTION: In Denmark, age-related macular degeneration (AMD) is the most common cause of blindness. To better understand current and future challenges, we estimated and projected the annual number of patients with neovascular AMD and geographic atrophy in Denmark from 2016 to 2060. METHODS: Detailed age- and gender-stratified prevalence estimates of neovascular AMD and geographic atrophy in a Scandinavian population were identified and applied to age- and gender-stratified population numbers provided by Statistics Denmark...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115207/self-evaluated-competence-in-trauma-reception
#5
Kristin Julia Steinthorsdottir, Peter Svenningsen, Rasmus Fabricius, Lars Bo Svendsen, Jens Hillingsø, Martin Sillesen
INTRODUCTION: No formal training requirements exist for trauma teams in Denmark. The aim of this study was to investigate the point prevalence level of training and the self-evaluated competence of doctors involved in trauma care. METHODS: On two nights, all doctors on call at departments involved in trauma care were interviewed and answered a structured questionnaire pertaining to their level of training and self-evaluated level of competence in relevant skills...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115206/bronchoscopy-in-children-suspected-of-lower-airway-aspiration
#6
Sine Holst-Albrechtsen, Søren Kristensen, Knud Larsen
INTRODUCTION: Foreign body aspiration (FBA) of the bronchial tree may be a life-threatening condition in children. This retrospective study explores the anamnestic, clinical and objective findings in patients with FBA to the lungs and evaluates the frequency and outcome of the condition in patients in the age group of highest risk. METHOD: Medical files from patients below 18 years of age who had a foreign body removed from the lungs in our hospital were extracted using the procedure code for removal of foreign bodies in the lower airways ("Danish Patient Register") in the period 1990-2013...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115205/falls-in-elderly-patients-are-not-treated-according-to-national-recommendations
#7
Marie Lillevang-Johannsen, Johannes Grand, Maurice Lembeck, Ann-Kristine Giger, Joanna Drozdowska, Jolanta Zajworoniuk-Wlodarczyk, Anna Gaj, Ellen Holm
INTRODUCTION: The aim of this study was to evaluate health professionals' compliance with recommendations from the Danish Health Authority (DHA) concerning falls, to study the prevalence of acute hospital visits due to falls, and to compare characteristics of fall patients in two geographically and socioeconomically different areas of Denmark. METHODS: The study was conducted in the emergency departments (ED) of Slagelse Hospital (SH) and Nykøbing Falster Hospital (NFH), both located in Denmark...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115204/use-of-the-smartphone-application-pregnant-with-diabetes
#8
Sidse Kjærhus Nørgaard, Vibeke Ladefoged Nichum, Charlotte Barfred, Hellen Marguerite Juul, Anna Lilja Secher, Lene Ringholm, Peter Damm, Elisabeth Reinhardt Mathiesen
INTRODUCTION: The aim of this article was to evaluate the awareness and use of the smartphone application (app) "Pregnant with Diabetes" locally, nationally and internationally. METHODS: In 2013, a patient initiated collaboration with the staff at Centre for Pregnant Women with Diabetes, Rigs-hospitalet, to develop the app "Pregnant with Diabetes". The app communicates clinically important antenatal health information to women with diabetes, based on recommendations from our centre...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115203/cholecystectomy-for-uncomplicated-gallbladder-stones-does-not-follow-evidence-based-recommendations
#9
Benjamin Pedersen, Mark B Ellebæk, Allan Dorfelt, Niels Qvist
INTRODUCTION: The introduction of laparoscopic cholecystectomy was followed by a steep increase in the cholecystectomy rate, which has remained on an unchanged, high level. The main indication for cholecystectomy in Denmark in cases with uncomplicated gallbladder stones is socially debilitating pain. The objective of the present study was to investigate whether the indication "socially debilitating pain" was reported in the patient's file when he or she was referred to surgery. METHODS: Hospital files for all patients referred to surgical evaluation for uncomplicated gallbladder stones from Odense University Hospital's service area (approximately 449,000 inhabitants) within a one-year period (2014) were reviewed...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975892/introducing-standing-weight-bearing-mri-in-the-di-agnostics-of-low-back-pain-and-degenerative-spinal-disorders
#10
Bjarke Brandt Hansen
This PhD thesis is based on three scientific papers. In 2011 the Parker Institute the department of rheumatology introduced standing weight-bearing MRI (G-Scan, ESAOTE, Genova, Italy) in the diagnostic of low back pain patients. Unfortunately, we experienced a substantial risk of fainting (orthostatic syncope) during standing pMRI. In paper 1 we present in an observational study that the risk of fainting (19%) during standing pMRI could almost be eliminated by the use of an external pneumatic compression device (2%)...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975891/local-immune-response-in-cutaneous-basal-cell-carcinoma
#11
Silje Haukali Omland
BCC is an immunogenic tumor highlighted by the increased risk in immunosuppressed individuals and the frequent occurrence of tumor infiltrating lymphocytes (TILs) in the tumor surroundings. Immunotherapy is evolving as a promising treatment strategy for several cancer types where topical immunostimulators are among the possibilities for superficial BCC. The overall aim of this thesis is to characterize the immunologic response upon BCC as well as characterizing the surrounding tumor stroma. The aim was achieved by the use of a variety of laboratory techniques; immunohistochemistry, immunoflourescence, qRT-PCR and NGS...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975890/identification-and-validation-of-novel-prognostic-markers-in-renal-cell-carcinoma
#12
Maj Rabjerg
Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the surveillance protocols for follow-up of RCC patients after radical nephrectomy are based on the American Joint Committee on Cancers (AJCC) pathological tumor-node-metastasis (TNM) classification system...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975889/the-evolution-of-the-sentinel-node-procedure-in-the-treatment-of-breast-cancer
#13
Tove Filtenborg Tvedskov
This thesis is based on 10 original articles, of which 3 were previously included in the PhD thesis "Staging of women with breast cancer after introduction of sentinel node guided axillary dissection". In the PhD thesis is was shown that the introduction of sentinel lymph node dissection (SLND) in the treatment of breast cancer in Denmark has resulted in an increased identification of patients with micrometastases or isolated tumor cells (ITC) in the lymph nodes. Not all these small metastases are likely to disseminate to non-sentinel nodes...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975888/self-perceived-readiness-to-perform-at-the-attending-level-following-surgical-specialist-training-in-denmark
#14
Rasmus Fabricius, Martin Sillesen, Morten Sejer Hansen, Randi Beier-Holgersen
INTRODUCTION: Great effort has been invested in improving the educational aspect of the Danish five-year national surgical residency programme. Among other initiatives, an updated logbook containing specific objectives was implemented in 2015. The effect of current and prior educational efforts has not previously been studied. In the present study, we aim to investigate the role of supervision in the national surgical residency programme and the self-perceived readiness to undertake the role of a specialist doctor in gastrointestinal surgery in a cohort of gastrointestinal surgeons graduating in 2012 and 2013...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975887/quality-assurance-of-the-western-denmark-heart-registry-a-population-based-healthcare-register
#15
Linda Aagaard Rasmussen, Hans Erik Bøtker, Lisette Okkels Jensen, Jan Ravkilde, Lars Riber, Per Hostrup Nielsen, Jan Jesper Andreasen, Carl-Johan Jakobsen
INTRODUCTION: During the past decade, the mandatory population-based healthcare database, the Western Denmark Heart Registry (WDHR), has provided the data for several research projects. As in most clinical registries, the data quality has not been validated thoroughly. This study was undertaken to evaluate the quality of registrations in the WDHR. METHODS: The audit supervised procedures from involved departments that were performed in 2013. An experienced research nurse completed data collection, and an experienced consultant evaluated the agreement between the WDHR and patient records...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975886/intra-corporeal-anastomosis-in-laparoscopic-surgery-for-benign-colorectal-disease
#16
Jacob Antonsen, Rogini Balachandran, Finn Stigsen Holm, Ismail Gögenur
INTRODUCTION: Recent studies have described the benefits of performing bowel resections for benign and malignant diseases as a total laparoscopic procedure with intra-corporeal anastomosis. We describe our preliminary experience with total laparoscopic surgery for benign lower gastrointestinal diseases. METHODS: All patients (n = 32) who had received elective bowel surgery with intra-corporeal anastomosis for benign diseases between November 2013 and August 2015 were included in this retrospective study...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975885/pet-ct-findings-in-patients-with-polymyalgia-rheumatica-without-symptoms-of-cranial-ischaemia
#17
Alexander Lund-Petersen, Anne Voss, Helle Laustrup
INTRODUCTION: Polymyalgia rheumatica (PMR) is an inflammatory disorder that affects the elderly. At present, evidence is limited regarding the usefulness of positron emission tomography-computed tomography (PET-CT) in the diagnosis of PMR. This study aimed to compare patient characteristics and symptoms with PET-CT findings in a Danish population of PMR patients without clinical symptoms of giant cell arteritis. METHODS: The medical records of 50 Danish PET-CT-scanned patients with PMR were reviewed...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975884/anaesthesia-in-patients-undergoing-esophago-gastro-duodenoscopy-for-suspected-bleeding
#18
Ida Helsø, Martin Risom, Therese Risom Vestergaard, Nicolai Bang Foss, Steffen Rosenstock, Morten Hylander Møller, Lars Hyldborg Lundstrøm, Nicolai Lohse
INTRODUCTION: Upper gastrointestinal bleeding (UGIB) is a common emergency. Currently, there are no agreed guidelines on the level of anaesthetic support required in patients undergoing acute esophago-gastro-duodendoscopy (EGD). METHODS: An online questionnaire comprising 19 questions was distributed to all members of the Danish Association of Anaesthesiology and Intensive Care (n = 1,418) and the Danish Society of Anaesthesiologists in Training (n = 566). The questions concerned clinical practice for anaesthesia care to patients undergoing EGD for suspected UGIB and availability of local guidelines...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975883/prehospital-interventions-before-and-after-implementation-of-a-physician-staffed-helicopter
#19
Asger Sonne, Sandra Wulffeld, Jacob Steinmetz, Lars S Rasmussen, Rasmus Hesselfeldt
INTRODUCTION: Implementation of a physician-staffed helicopter emergency medical service (HEMS) in eastern Denmark was associated with increased survival for severely injured patients. This study aimed to assess the potential impact of advanced prehospital interventions by comparing the proportion of patients who received those interventions before and after the HEMS implementation. METHODS: A post-hoc analysis of a prospective before-after study. We included trauma patients with Injury Severity Scores above three who had been admitted to seven emergency departments or one level 1 trauma centre in the course of a five-month period before and a 12-month period after the HEMS implementation...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28874246/early-onset-coronary-artery-disease-clinical-and-hereditary-aspects
#20
Morten Krogh Christiansen
A family history of coronary artery disease (CAD) is an important risk factor for adverse coronary events, in particular if the disease has an early onset. The risk of CAD is influenced by genetic and environmental factors with a greater genetic contribution earlier in life. Through recent years the advances in genetic techniques has led to an increased understanding of the genetic background of CAD, which may potentially be translated into clinical use. The studies of this thesis aimed to investigate the burden of conventional risk factors and control in early-onset CAD (i...
September 2017: Danish Medical Journal
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