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Danish Medical Journal

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https://www.readbyqxmd.com/read/28385175/on-the-role-of-the-gut-in-diabetic-hyperglucagonaemia
#1
Asger Lund
Patients with type 2 diabetes are characterised not only by compromised insulin secretion and action, but also by elevated plasma concentrations of the 29-amino acid peptide hormone glucagon, which generally is thought of as a pancreas-derived hormone (produced in and secreted from alpha cells in the islet of Langerhans). In patients with diabetes, circulating glucagon concentrations are elevated in the fasting state and fail to decrease appropriately or even increase in response to ingestion of nutrients. Glucagon is known to be a potent stimulator of hepatic glucose production, and, thus, the elevated glucagon concentrations in diabetes contribute decisively to the predominating trait of patients with diabetes namely hyperglycaemia...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385174/take-home-training-in-laparoscopy
#2
Ebbe Thinggaard
When laparoscopy was first introduced, skills were primarily taught using the apprenticeship model. A limitation of this method when compared to open surgery, was that it requires more time to practise and more frequent learning opportunities in clinical practice. The unique set of skills required in laparoscopy highlighted the need for new training methods that reduce the need for supervision and do not put the patient at risk. Simulation training was developed to meet this need. The overall purpose of this thesis was to explore simulation-based laparoscopic training at home...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#3
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385172/the-rate-of-invasive-testing-for-trisomy-21-is-reduced-after-implementation-of-nipt
#4
Louise Bjerregaard, Anne Betsagoo Stenbakken, Camilla Skov Andersen, Line Kristensen, Cecilie Vibeke Jensen, Peter Skovbo, Anne Nødgaard Sørensen
INTRODUCTION: The non-invasive prenatal test (NIPT) was introduced in the North Denmark Region in March 2013. NIPT is offered as an alternative to invasive tests if the combined first trimester risk of trisomy 21 (T21) is ≥ 1:300. The purpose of this study was to investigate the effect of NIPT implementation among high-risk pregnancies in a region with existing first-trimester combined screening for T21. The primary objective was to examine the effect on the invasive testing rate. METHODS: This was a retrospective observational study including high-risk singleton pregnancies in the North Denmark Region...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385171/children-and-adolescents-admitted-to-a-university-level-trauma-centre-in-denmark-2002-2011
#5
Danny Stefan Ekström, Rasmus Hviid Larsen, Jens Martin Lauritsen, Christian Færgemann
INTRODUCTION: The epidemiology of children or adolescents admitted to a Scandinavian trauma centre is largely unknown. The aim of this paper was to describe the epi-demiology and severity of potentially severely injured children and adolescents admitted to a university hospital trauma centre. METHODS: This was a descriptive study of all children and adolescents aged 0-17 admitted to the university level trauma centre at Odense University Hospital, Denmark in the 2002-2011 period...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385170/danish-survey-of-acetabular-component-positioning-practice-during-primary-total-hip-arthroplasty
#6
Dana Cotong, Anders Troelsen, Henrik Husted, Kirill Gromov
INTRODUCTION: The Lewinnek and Callanan "safe zones" have been widely used to minimise the dislocation fre-quency in total hip arthroplasty (THA), but recent studies have questioned the association between "safe zones" and lower dislocation rates. The purpose of this study was to investigate: 1) if hip surgeons agree on a specific "safe zone" for cup positioning and 2) surgeons' surgical practice patterns regarding recurring instability in primary THA. METHODS: A survey was performed among hip surgeons during the 2015 Annual Meeting of the Danish Orthopaedic Society...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385169/improved-functional-outcome-after-hip-fracture-is-associated-with-duration-of-rehabilitation-but-not-with-waiting-time-for-rehabilitation
#7
Tonny Jaeger Pedersen, Louise Nicole Bie Bogh, Jens Martin Lauritsen
INTRODUCTION: The aim of this study was to explore the relationship between "waiting time to onset of municipal rehabilitation", "length of municipal rehabilitation" and the attained level of function four months after the hip fracture. METHODS: Among a consecutive series of 156 patients, the 116 patients who were recommended a municipal rehabilitation sequence after discharge were included. The expos-ures were waiting time in days and duration in hours of the municipal rehabilitation...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385168/inferior-reliability-of-vas-scoring-compared-with-international-society-of-the-knee-reporting-system-for-abstract-assessment
#8
Ole Rahbek, Steen L Jensen, Martin Lind, Jeannette Ø Penny, Thomas Kallemose, Thomas Jakobsen, Anders Troelsen
INTRODUCTION: Knowledge of how abstracts may be se-lected for medical conferences in an efficient and reliable manner is sparse. To improve abstract selection, the Danish Orthopaedic Society implemented the International Society of the Knee (ISK) quality-of-reporting system and visual analogue scale (VAS) scoring for abstract evaluation at its 2014 Annual Congress. We sought to find out if a simple VAS score was more reliable than a multiple-question system for assessment of over-all abstract quality...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385167/hearing-screening-in-newborns-in-the-central-denmark-region
#9
Linda Busk Linnebjerg, Anita Ekman Hansen, Troels Reinholdt Møller
INTRODUCTION: In 2005, a nationwide programme on hearing screening in newborns was launched in Denmark. The purpose of the programme was to ensure early detection of hearing loss in newborns and to institute subsequent treatment. The aim of this study was to assess whether the Central Denmark Region observes the guidelines of the Danish Health and Medicines Authority (DHMA) for neonatal hearing. In addition, we wanted to identify factors that may influence screening density positively or negatively...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260603/the-role-of-genetics-on-migraine-induction-triggered-by-cgrp-and-pacap38
#10
REVIEW
Song Guo
Migraine has a strong genetic component and is characterized by multiphasic events including an initial premonitory phase with premonitory symptoms (PS). Calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide-38 (PACAP38) are endogenous neuropeptides that can trigger migraine attacks and have in recent years gained considerable interest in the migraine field. Yet, the exact pathophysiological mechanisms underlying CGRP- and PACAP38-induced attacks are not fully clarified. Human provocation models have shown that these peptides induce attacks in only two- thirds of migraine patients...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260602/recovery-after-abdominal-wall-reconstruction
#11
REVIEW
Kristian Kiim Jensen
Incisional hernia is a common long-term complication to abdominal surgery, occurring in more than 20% of all patients. Some of these hernias become giant and affect patients in several ways. This patient group often experiences pain, decreased perceived body image, and loss of physical function, which results in a need for surgical repair of the giant hernia, known as abdominal wall reconstruction. In the current thesis, patients with a giant hernia were examined to achieve a better understanding of their physical and psychological function before and after abdominal wall reconstruction...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260601/outcomes-of-different-bearings-in-total-hip-arthroplasty-implant-survival-revision-causes-and-patient-reported-outcome
#12
REVIEW
Claus Varnum
Total hip arthroplasty (THA) is a common and successful treatment of patients suffering from severe osteoarthritis that significantly reduces pain and improves hip function and quality of life. Traditionally, the outcome of THA has been evaluated by orthopaedic surgeons and assessed in morbidity and mortality rates, and implant survival. As patients and surgeons may assess outcome after THA differently, patient-reported outcomes (PROMs) have gained much more interest and are today recognized as very important tools for evaluating the outcome and satisfaction after THA...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260600/trends-in-population-blood-pressure-and-determinant-factors-for-population-blood-pressure
#13
Ulla Overgaard Andersen
Strategies to reduce the burden of blood pressure attributable diseases require knowledge of secular trend in PBP and its determinants. The issues were investigated in the Copenhagen City Heart Study. The design of CCHS is a repeated measures study. Such designs are uniquely suited to studying changes of an outcome and what risk factors may be associated with that outcome. Repeated measures studies are very well suited for trend analysis by using mixed effect analyses. SBP decreased about 2 mmHg in 25 years...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260599/peritonsillar-abscess-clinical-aspects-of-microbiology-risk-factors-and-the-association-with-parapharyngeal-abscess
#14
REVIEW
Tejs Ehlers Klug
PTA is a collection of pus located between the tonsillar capsule and the pharyngeal constrictor muscle. It is considered a complication of acute tonsillitis and is the most prevalent deep neck infection (approximately 2000 cases annually in Denmark) and cause of acute admission to Danish ENT departments. Teenagers and young adults are most commonly affected and males may predominate over females. However, no studies of age- and gender-stratified incidence rates have previously been published. Furthermore, smoking may be associated with increased risk of peritonsillar abscess (PTA) development, although the magnitude of the association has not been estimated...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260598/the-efficacy-of-acupuncture-on-menopausal-symptoms-acom-study-protocol-for-a-randomised-study
#15
RANDOMIZED CONTROLLED TRIAL
Kamma Sundgaard Lund, John Brodersen, Volkert Siersma, Frans Boch Waldorff
INTRODUCTION: Around 75% of menopausal women experience hot flushes (HF) and 10-20% of all postmenopausal women find this very distressing. The aim of this study is to evaluate the efficacy of acupuncture on moderate-to-severe menopausal symptoms in general and HF in particular. METHODS: An un-blinded randomised trial (cross-over) with 1:1 allocation to early (intervention) versus late (control) acupuncture. The included women suffer from moderate-to-severe HF and will receive a weekly treatment during five consecutive weeks in the following predefined acupuncture points: CV-3, CV-4, LR-8, SP-6, SP-9...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260597/social-relations-and-loneliness-among-older-patients-consulting-their-general-practitioner
#16
Tina Drud Due, Håkon Sandholdt, Frans Boch Waldorff
INTRODUCTION: Social relations are important for people and affect their quality of life, morbidity and mortality. This holds true especially for older persons. General practitioners (GPs) are in a unique position to address social relations and loneliness; however, no GP population-based studies have assessed older patients' social relations and loneliness. The aim of this study was to analyse the social relations and loneliness of patients aged 65 years and above consulting their GP...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260596/robotic-assisted-laparoscopic-hysterectomy-for-women-with-endometrial-cancer
#17
Suzanne Forsyth Herling, Ann M Møller, Connie Palle, Anja Grynnerup, Thordis Thomsen
INTRODUCTION: Robotic-assisted laparoscopic hysterectomy (RALH) has become a widely used approach for women with endometrial cancer and has replaced laparotomy. It has been questioned if the increased costs are justified by superior surgical outcomes. The aim of the present study was to examine the frequency, types and severity of post-operative complications after total abdominal hysterectomy (TAH) and RALH using the Clavien-Dindo classification of surgical outcomes. METHODS: A non-randomised, controlled before and after study of 360 women was conducted; 202 underwent RALH and 158 TAH (historical controls)...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260595/a-danish-nationwide-questionnaire-study-of-hepatitis-b-virus-screening-before-immunosuppressive-therapy
#18
Kristine Ifigenia Bunyoz, Henrik Krarup, Nina Weis
INTRODUCTION: Difficulty in identifying patients who are at risk for hepatitis B virus (HBV) reactivation makes it import-ant to screen for HBV before initiating immunosuppressive therapy. The aim of this study was to investigate screening procedures for HBV infection before initiation of immunosuppressive therapy and to explore HBV treatment strategies. METHODS: All Danish units of haematology, oncology, dermatology, rheumatology and gastroenterology using immunosuppressive agents were invited to fill out a questionnaire for The Danish Database for Hepatitis B and C...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260594/melanomas-of-the-vulva-and-vagina
#19
Sasia Skovsted, Karsten Nielsen, Jan Blaakær
INTRODUCTION: Malignant melanoma is a rare type of cancer in the vagina and vulva associated with a poor prognosis due to late diagnosis and early dissemination. Only a limited amount of literature exists on the condition. This study elucidates the effect of current treatment. METHODS: All patients diagnosed with malignant melanoma in the vagina or vulva at Aarhus University Hospital, Skejby, Denmark, in the period from 1996 to 2013 were included. Data were collected from the electronic patient records and from the Danish Pathology Register...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28260593/the-effect-of-two-grading-systems-on-the-performance-of-medical-students-during-oral-examinations
#20
COMPARATIVE STUDY
Shakoor Ba-Ali, Gregor B E Jemec, Birgit Sander, Peter B Toft, Preben Homøe, Henrik Lund-Andersen
INTRODUCTION: Either a pass/fail approach or a seven-point grading scale are used to evaluate students at the Danish universities. The aim of this study was to explore any effect of the assessment methods on student performances during oral exams. METHODS: In a prospective study including 1,037 examinations in three medical subjects, we investigated the difference in the test scores between the spring- and autumn semester. In the spring semester, the students could either pass or fail the subject (pass/fail) while in the following autumn semester, the students were assessed by tiered grading (seven-point grading scale)...
March 2017: Danish Medical Journal
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