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Clinical and Translational Allergy

Karine Adel-Patient, Guillaume Lezmi, Florence Anne Castelli, Sibylle Blanc, Hervé Bernard, Pascale Soulaines, Pascale Dumond, Sandrine Ah-Leung, Florence Lageix, Delphine de Boissieu, Naima Cortes-Perez, Stéphane Hazebrouck, François Fenaille, Christophe Junot, Christophe Dupont
Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is considered to be a non-IgE mediated food allergy. However, its pathogenesis remains poorly understood and biomarkers are lacking. We aimed to perform in-depth characterization of humoral and cellular immune responses in children with cow's milk (CM)-FPIES and investigated whether there is a FPIES metabolomic signature. Methods: Children with CM-FPIES and control subjects with an IgE-mediated CM allergy (IgE-CMA), both avoiding CM, were recruited on the day of an oral food challenge...
2018: Clinical and Translational Allergy
Marianne de Brito, Gisela Huebner, DedeeF Murrell, Peter Bullpitt, Karin Hartmann
We report two patients with normocomplementaemic urticarial vasculitis with impressive response to omalizumab. This contrasts recent reports on hypocomplementaemic urticarial vasculitis syndrome, highlighting the need for clinical trials of omalizumab in normocomplementaemic urticarial vasculitis.
2018: Clinical and Translational Allergy
Maija Bruun Haastrup, Jan Erik Henriksen, Charlotte Gotthard Mortz, Carsten Bindslev-Jensen
Background: Type I insulin allergy can be a challenging condition, and there is no international consensus on how to establish the diagnosis. Measurement of specific IgE and skin testing have been cornerstones in the diagnostic work-up. However, these tests have limitations, mainly lack of correlation between test results and clinical findings. At the Allergy Centre, Odense University Hospital, patients with suspected insulin allergy have been evaluated since 2003. The aim of this study was to establish a systematic approach to diagnose and treat patients with insulin allergy...
2018: Clinical and Translational Allergy
Jean Bousquet, Josep M Anto, Isabella Annesi-Maesano, Toni Dedeu, Eve Dupas, Jean-Louis Pépin, Landry Stephane Zeng Eyindanga, Sylvie Arnavielhe, Julia Ayache, Xavier Basagana, Samuel Benveniste, Nuria Calves Venturos, Hing Kin Chan, Mehdi Cheraitia, Yves Dauvilliers, Judith Garcia-Aymerich, Ingrid Jullian-Desayes, Chitra Dinesh, Daniel Laune, Jade Lu Dac, Ismael Nujurally, Giovanni Pau, Robert Picard, Xavier Rodo, Renaud Tamisier, Michael Bewick, Nils E Billo, Wienczyslawa Czarlewski, Joao Fonseca, Ludger Klimek, Oliver Pfaar, Jean-Marc Bourez
Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (the Allergy Diary , iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data...
2018: Clinical and Translational Allergy
Katleen Martens, Peter W Hellings, Brecht Steelant
Epithelial cell lines are often used to evaluate the effect of exogenous/endogenous stimuli on epithelial barrier function and innate immune responses in allergic airway diseases, without clear view on differences between epithelial cell lines and primary nasal epithelial cell responses. In this observational study, we compared the response of Calu-3 and primary nasal epithelial cells to two relevant exogenous stimuli: i.e. Staphylococcus aureus enterotoxin B (SEB) and house dust mite (HDM). Stimulation of Calu-3 cells with SEB decreased epithelial integrity in a dose dependent manner, which was associated with a significant increase in IL-6 and IL-8 production...
2018: Clinical and Translational Allergy
Maria Doulaptsi, Emmanuel Prokopakis, Sven Seys, Benoit Pugin, Brecht Steelant, Peter Hellings
Background: A visual analogue scale (VAS) is a psychometric instrument widely used in the Rhinology field to subjectively quantify patient's symptoms severity. In allergic rhinitis, VAS has been found to correlate well with the allergic rhinitis and its impact on asthma severity classification, as well as with rhinoconjunctivitis quality of life questionnaire. In chronic rhinosinusitis (CRS), total VAS score are often used to classify disease burden into mild, moderate, and severe, with few studies correlating VAS scores with more complex and validated instruments assessing disease-specific burden like Sino-Nasal Outcome Test (SNOT)-22...
2018: Clinical and Translational Allergy
I J Skypala, N W de Jong, E Angier, J Gardner, I Kull, D Ryan, C Venter, B J Vlieg-Boerstra, K Grimshaw
The multi-disciplinary team approach is an effective model for patient care. Allied health professionals (AHPs) are an important part of such teams, bringing specific knowledge and skills related to the target patient population. The AHPs most often involved in allergy care are nurses and dietitians. Nurses are often involved in the care of patients with all types of allergy and also with asthma, whilst allergy-specialist dietitians provide vital nutritional and dietary support for the diagnosis and management of food allergy...
2018: Clinical and Translational Allergy
Jinyan Yu, Xiaoqiu Liu, Yanlei Li, Shanshan Meng, Fei Wu, Bingdi Yan, Yanjun Xue, Tiangang Ma, Junling Yang, Jing Liu
Background: As the development of urbanization in China, the morbidity of allergic disease rise up prominently even in children, which may be partially associated with the excessively clean environment. It has been reported that common microorganism in rural environment shows protective effects on allergic disease by modulating TLRs-Tregs/Th cell axis. But the mechanism of this protection still needs to be elucidated in detail. We investigated the effects of maternal exposure to farming environment on the neonatal innate immune system, especially on the TLR-Treg-Th (Th1, Th2, Th9, and Th17) axis, in the Jilin province of China...
2018: Clinical and Translational Allergy
Jaap Akkerdaas, Muriel Totis, Brian Barnett, Erin Bell, Tom Davis, Thomas Edrington, Kevin Glenn, Gerson Graser, Rod Herman, Andre Knulst, Gregory Ladics, Scott McClain, Lars K Poulsen, Rakesh Ranjan, Jean-Baptiste Rascle, Hector Serrano, Dave Speijer, Rong Wang, Lucilia Pereira Mouriès, Annabelle Capt, Ronald van Ree
Background: Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions encountered in representative food consumption scenarios. Aim: To evaluate whether inclusion of more physiological conditions, such as sub-optimal and lower pepsin concentrations, in combination with pancreatin digestion, improved the performance of digestibility protocols used in characterization of protein stability...
2018: Clinical and Translational Allergy
Esben Eller, Antonella Muraro, Ronald Dahl, Charlotte Gotthard Mortz, Carsten Bindslev-Jensen
Backgroud: The severity of an allergic reaction can range from mild local symptoms to anaphylactic shock. To score this, a number of instruments have been developed, although heterogeneous in design and purpose. Severity scoring algorithms are therefore difficult to compare, but are frequently used beyond their initial purpose. Our objective was to compare the most used severity scoring instruments by a data-driven approach on both milder reactions and anaphylaxis. Methods: All positive challenges to foods or drugs (n = 2828) including anaphylaxis (n = 616) at Odense University Hospital, Denmark from 1998 to 2016 were included and severity was scored according to Sampson5...
2018: Clinical and Translational Allergy
Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun, Kunmei Ji
Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE plays a vital role in the development of acute allergic reactions and chronic inflammatory allergic diseases, making its control particularly important in the treatment of IgE-mediated allergic diseases. This review provides an overview of the current state of IgE targeted therapy development, focusing on three areas of translational research: IgE neutralization in blood; IgE-effector cell elimination; and IgE+ B cell reduction...
2018: Clinical and Translational Allergy
R Muñoz-Cano, P Ribó, G Araujo, E Giralt, J Sanchez-Lopez, A Valero
Background: Allergic rhinitis (AR) is a highly prevalent disease that generates high social and health care costs and also has a significant effect on quality of life and quality of sleep. It has also been related to some psychological disorders like anxiety or depression. Objective: To evaluate anxiety, depression, and quality of sleep and life alteration in a group of patients with perennial AR compared to a group of seasonal AR patients. Methods: Six-hundred seventy adults (> 18 years) with perennial and seasonal AR were recruited consecutively in 47 centers in Spain...
2018: Clinical and Translational Allergy
Janina Köther, Alicia Mandl, Silke Allekotte, Anatoli Astvatsatourov, Janin Chwieralski, Jan-Patrick Liedtke, Ursula Pieper-Fürst, Esther Raskopf, Kija Shah-Hosseini, Ralph Mösges
Background: Clinical practice needs a common parameter that can provide an early, reliable estimation of the outcome of sublingual immunotherapy (SLIT) in an upcoming pollen season. We investigated whether the conjunctival provocation test (CPT) can predict the beneficial outcome of SLIT in patients with allergic rhinoconjunctivitis after 4 weeks of treatment. Methods: We conducted two separate prospective, randomized, double-blind, placebo-controlled, multicenter trials...
2018: Clinical and Translational Allergy
Maria D'Amato, Antonio Molino, Giovanna Calabrese, Lorenzo Cecchi, Isabella Annesi-Maesano, Gennaro D'Amato
The increasing use, and sometimes the abuse, particularly in industrialized countries of air conditioning at home, in car, hotel and shopping centres has highlighted new emerging public health issues, resulting from exposure of the airways to cool air or, more properly, resulting from sudden temperature changes. This is part of a wider problem, relating to air quality in indoor environment, such as homes or offices, where people spend more than 90% of their time. In particular, if indoor exposure occurs quickly and without any gradual adaptation to a temperature 2°-3° lower than the external temperature and especially with a 5° difference (avoiding indoor temperature below 24°) and an humidity between 40 and 60%, there is a risk of negative consequences on the respiratory tract and the patient risks to be in a clinical condition characterized by an exacerbation of the respiratory symptoms of his chronic respiratory disease (asthma and COPD) within a few hours or days...
2018: Clinical and Translational Allergy
Haiyu Hong, Dan Wang, Kai Sen Tan, Rui Zheng, Fenghong Chen, Wenxiang Gao, Haixin He, Jianbo Shi, Yunping Fan, Qintai Yang, Yueqi Sun
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study was to evaluate the diagnostic values of sinus computed tomography (CT) for GC-sensitivity in patients with CRSwNP. Methods: We conducted a prospective, single-blinded study of 47 consecutive patients with CRSwNP...
2018: Clinical and Translational Allergy
C Bachert, J Bousquet, P Hellings
Background: This article summarizes a EUFOREA symposium, presented during the European Rhinology Research Forum in Brussels (9-10 November 2017; which focused on novel pathways and therapeutic approaches in allergic rhinitis (AR). Main body: AR remains under-diagnosed, under-estimated and under-treated. A key component in understanding the AR landscape has been the realization of a significant mismatch between how physicians instruct AR patients to manage their disease and what AR patients actually do in real life...
2018: Clinical and Translational Allergy
Ying Zhou, Haoyuan Jia, Xuming Zhou, Yubao Cui, Jun Qian
Background: Spider mites, including Tetranychus urticae , Panonychus citri , and Panonychus ulmi , are common pests in gardens, greenhouses, and orchards. Exposure, particularly occupational exposure, to these organisms may lead to the development of respiratory or contact allergies. However, the prevalence of sensitivity to spider mites is unclear. Methods: We examined the literature to generate an estimate of the global prevalence of allergies to spider mites...
2018: Clinical and Translational Allergy
Emilia Mikola, Varpu Elenius, Maria Saarinen, Oscar Palomares, Matti Waris, Riitta Turunen, Tuomo Puhakka, Lotta Ivaska, Beate Rückert, Alar Aab, Tero Vahlberg, Tytti Vuorinen, Tobias Allander, Carlos A Camargo, Mübeccel Akdis, Cezmi A Akdis, Tuomas Jartti
Background: Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis. Methods: Tonsils of 89 surgical patients with tonsillar hypertrophy (n = 47) or recurrent tonsillitis (n = 42) were analysed...
2018: Clinical and Translational Allergy
Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská, Marek Malý
Background: The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite and cockroach allergens in Central Europe has not been established yet. Methods: We assessed sensitization profiles of allergy patients in a Central European region in regard to sensitization to mites and cockroach...
2018: Clinical and Translational Allergy
Bertine M J Flokstra-de Blok, Thecla M Brakel, Marian Wubs, Ben Skidmore, Janwillem W H Kocks, Joanne N G Oude Elberink, Marie-Louise A Schuttelaar, Jantina L van der Velde, Thys van der Molen, Anthony E J Dubois
Background: The allergy management support system (AMSS) was developed to assist general practitioners (GPs) to handle the increasing burden of allergic diseases and facilitates the diagnosis and management of allergy. The aim of this cluster-randomized controlled pilot study was to test the feasibility of this AMSS for primary care. Methods: GPs received diagnostic and management recommendations generated by the AMSS in addition to sIgE-test results (intervention) or GPs received sIgE-test results only (control)...
2018: Clinical and Translational Allergy
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