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Clinical and Translational Allergy

Papapit Tuchinda, Kanokvalai Kulthanan, Leena Chularojanamontri, Sittiroj Arunkajohnsak, Sutin Sriussadaporn
Background: Vitamin D has been reported to be associated with many allergic diseases. There are a limited number of the studies of vitamin D supplementation in patients with chronic spontaneous urticaria (CSU). This study aims to study the relationship between vitamin D and CSU in terms of serum vitamin D levels, and the outcomes of vitamin D supplementation. Methods: A literature search of electronic databases for all relevant articles published between 1966 and 2018 was performed...
2018: Clinical and Translational Allergy
Rui Zheng, Dan Wang, Kai Wang, Wen-Xiang Gao, Qin-Tai Yang, Li-Jie Jiang, Min Zhou, Yu-Jie Cao, Jianbo Shi, Yueqi Sun
Background: Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure the expressions of IL-17RB, ST2 and TSLPR, receptor of IL-25, IL-33, and TSLP respectively, on myeloid DCs in nasal polyps (NP) and evaluate their association with local Th2 inflammation and disease severity in patients with NP. Methods: Samples were collected from 30 NP patients and 16 control subjects recruited prospectively...
2018: Clinical and Translational Allergy
J Bousquet, C A Akdis, C Grattan, P A Eigenmann, K Hoffmann-Sommergruber, P W Hellings, I Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. There was substantial progress in 2017 in the identification of basic mechanisms of allergic and respiratory disease and the translation of these mechanisms into clinics...
2018: Clinical and Translational Allergy
Kiwako Yamamoto-Hanada, Tohru Kobayashi, Hywel C Williams, Masashi Mikami, Mayako Saito-Abe, Kumiko Morita, Osamu Natsume, Miori Sato, Motoko Iwama, Yumiko Miyaji, Makiko Miyata, Shinichiro Inagaki, Fukuie Tatsuki, Narita Masami, Shoji F Nakayama, Hiroshi Kido, Hirohisa Saito, Yukihiro Ohya
Background: Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic rhinitis. Recent evidence suggests that sensitization to foods may occur through a defective skin barrier which is common in atopic dermatitis in early life. We hypothesize that therapeutic aggressive intervention to treat new onset atopic dermatitis may prevent the development of later allergen sensitization, and associated food allergy, asthma, and allergic rhinitis...
2018: Clinical and Translational Allergy
A Sogo, M J Cruz, M J Amengual, X Muñoz
We present the case of a 34-year-old male patient employed for 8 years in a company manufacturing and packaging animal feed. The patient developed occupational asthma to dry Gammarus powder. The diagnosis was confirmed by specific bronchial provocation test. The determination of specific IgE antibodies was positive for Pen m 4, a sarcoplasmic calcium binding protein, with a level of 6.7 ISU-E. The sensitization to Pen m 4 described here may identify a new allergen causing occupational asthma in these workers...
2018: Clinical and Translational Allergy
I Suárez-Lorenzo, F Rodríguez de Castro, D Cruz-Niesvaara, E Herrera-Ramos, C Rodríguez-Gallego, T Carrillo-Diaz
Background and objective: Severe alpha1 antitrypsin deficiency has been clearly associated with pulmonary emphysema, but its relationship with bronchial asthma remains controversial. Some deficient alpha 1 antitrypsin (AAT) genotypes seem to be associated with asthma development. The objective of this study was to analyze the distribution of AAT genotypes in asthmatic patients allergic to house dust mites (HDM), and to asses a possible association between these genotypes and severe asthma...
2018: Clinical and Translational Allergy
J Bousquet, S Arnavielhe, A Bedbrook, M Bewick, D Laune, E Mathieu-Dupas, R Murray, G L Onorato, J L Pépin, R Picard, F Portejoie, E Costa, J Fonseca, O Lourenço, M Morais-Almeida, A Todo-Bom, A A Cruz, J da Silva, F S Serpa, M Illario, E Menditto, L Cecchi, R Monti, L Napoli, M T Ventura, G De Feo, D Larenas-Linnemann, M Fuentes Perez, Y R Huerta Villabolos, D Rivero-Yeverino, E Rodriguez-Zagal, F Amat, I Annesi-Maesano, I Bosse, P Demoly, P Devillier, J F Fontaine, J Just, T P Kuna, B Samolinski, A Valiulis, R Emuzyte, V Kvedariene, D Ryan, A Sheikh, P Schmidt-Grendelmeier, L Klimek, O Pfaar, K C Bergmann, R Mösges, T Zuberbier, R E Roller-Wirnsberger, P Tomazic, W J Fokkens, N H Chavannes, S Reitsma, J M Anto, V Cardona, T Dedeu, J Mullol, T Haahtela, J Salimäki, S Toppila-Salmi, E Valovirta, B Gemicioğlu, A Yorgancioglu, N Papadopoulos, E P Prokopakis, S Bosnic-Anticevich, R O'Hehir, J C Ivancevich, H Neffen, E Zernotti, I Kull, E Melen, M Wickman, C Bachert, P Hellings, S Palkonen, C Bindslev-Jensen, E Eller, S Waserman, M Sova, G De Vries, M van Eerd, I Agache, T Casale, M Dykewickz, R N Naclerio, Y Okamoto, D V Wallace
mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies...
2018: Clinical and Translational Allergy
Rishma Chooniedass, Beverley Temple, Donna Martin, Allan Becker
Background: Children with life threatening food allergies live with the constant threat of a fatal reaction, and caregivers must always be prepared to treat with an epinephrine auto-injector (EAI). This interpretive phenomenological study explored parents' perceptions and lived experiences with prescribed EAI use for their child. Methods: The purposive sample included ten parents of five children under 12 years of age, diagnosed with a food allergy and prescribed with an EAI who recently experienced anaphylaxis...
2018: Clinical and Translational Allergy
Andrea Zanichelli, Markus Magerl, Hilary J Longhurst, Werner Aberer, Teresa Caballero, Laurence Bouillet, Anette Bygum, Anete S Grumach, Jaco Botha, Irmgard Andresen, Marcus Maurer
The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over time...
2018: Clinical and Translational Allergy
Sara Huber, Roland Lang, Markus Steiner, Lorenz Aglas, Fatima Ferreira, Michael Wallner, Thomas Hawranek, Gabriele Gadermaier
Background: The clinical benefit of allergen-specific immunotherapy (AIT) involves induction of blocking antibodies. It is not clear if these antibodies function via steric hindrance alone or a combination of levels, avidities, and epitope specificities, and clinical outcome cannot be predicted. We aim to in-depth characterize serum antibody profiles during birch pollen AIT, investigate therapy-induced antibodies for their capacity to block IgE binding to Bet v 1 and correlate data with clinical outcomes...
2018: Clinical and Translational Allergy
Natalie Katharina Yvonne Gedon, Ralf Steffen Mueller
The purpose of this review article is to give an overview of atopic dermatitis in companion animals and of recent developments including knowledge on immunological background, novel treatment options and difficulties in disease management. The prevalence of hypersensitivities seems to be increasing. The pathogenetic mechanisms are not fully understood, yet multiple gene abnormalities and altered immunological processes are involved. In dogs and cats, the diagnosis of atopic dermatitis is based on history, clinical examination and exclusion of other differential diagnoses...
2018: Clinical and Translational Allergy
Karine Adel-Patient, Guillaume Lezmi, Florence Anne Castelli, Sibylle Blanc, Hervé Bernard, Pascale Soulaines, Pascale Dumond, Sandrine Ah-Leung, Florence Lageix, Delphine de Boissieu, Naima Cortes-Perez, Stéphane Hazebrouck, François Fenaille, Christophe Junot, Christophe Dupont
Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is considered to be a non-IgE mediated food allergy. However, its pathogenesis remains poorly understood and biomarkers are lacking. We aimed to perform in-depth characterization of humoral and cellular immune responses in children with cow's milk (CM)-FPIES and investigated whether there is a FPIES metabolomic signature. Methods: Children with CM-FPIES and control subjects with an IgE-mediated CM allergy (IgE-CMA), both avoiding CM, were recruited on the day of an oral food challenge...
2018: Clinical and Translational Allergy
Marianne de Brito, Gisela Huebner, DedeeF Murrell, Peter Bullpitt, Karin Hartmann
We report two patients with normocomplementaemic urticarial vasculitis with impressive response to omalizumab. This contrasts recent reports on hypocomplementaemic urticarial vasculitis syndrome, highlighting the need for clinical trials of omalizumab in normocomplementaemic urticarial vasculitis.
2018: Clinical and Translational Allergy
Maija Bruun Haastrup, Jan Erik Henriksen, Charlotte Gotthard Mortz, Carsten Bindslev-Jensen
Background: Type I insulin allergy can be a challenging condition, and there is no international consensus on how to establish the diagnosis. Measurement of specific IgE and skin testing have been cornerstones in the diagnostic work-up. However, these tests have limitations, mainly lack of correlation between test results and clinical findings. At the Allergy Centre, Odense University Hospital, patients with suspected insulin allergy have been evaluated since 2003. The aim of this study was to establish a systematic approach to diagnose and treat patients with insulin allergy...
2018: Clinical and Translational Allergy
Jean Bousquet, Josep M Anto, Isabella Annesi-Maesano, Toni Dedeu, Eve Dupas, Jean-Louis Pépin, Landry Stephane Zeng Eyindanga, Sylvie Arnavielhe, Julia Ayache, Xavier Basagana, Samuel Benveniste, Nuria Calves Venturos, Hing Kin Chan, Mehdi Cheraitia, Yves Dauvilliers, Judith Garcia-Aymerich, Ingrid Jullian-Desayes, Chitra Dinesh, Daniel Laune, Jade Lu Dac, Ismael Nujurally, Giovanni Pau, Robert Picard, Xavier Rodo, Renaud Tamisier, Michael Bewick, Nils E Billo, Wienczyslawa Czarlewski, Joao Fonseca, Ludger Klimek, Oliver Pfaar, Jean-Marc Bourez
Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (the Allergy Diary , iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data...
2018: Clinical and Translational Allergy
Katleen Martens, Peter W Hellings, Brecht Steelant
Epithelial cell lines are often used to evaluate the effect of exogenous/endogenous stimuli on epithelial barrier function and innate immune responses in allergic airway diseases, without clear view on differences between epithelial cell lines and primary nasal epithelial cell responses. In this observational study, we compared the response of Calu-3 and primary nasal epithelial cells to two relevant exogenous stimuli: i.e. Staphylococcus aureus enterotoxin B (SEB) and house dust mite (HDM). Stimulation of Calu-3 cells with SEB decreased epithelial integrity in a dose dependent manner, which was associated with a significant increase in IL-6 and IL-8 production...
2018: Clinical and Translational Allergy
Maria Doulaptsi, Emmanuel Prokopakis, Sven Seys, Benoit Pugin, Brecht Steelant, Peter Hellings
Background: A visual analogue scale (VAS) is a psychometric instrument widely used in the Rhinology field to subjectively quantify patient's symptoms severity. In allergic rhinitis, VAS has been found to correlate well with the allergic rhinitis and its impact on asthma severity classification, as well as with rhinoconjunctivitis quality of life questionnaire. In chronic rhinosinusitis (CRS), total VAS score are often used to classify disease burden into mild, moderate, and severe, with few studies correlating VAS scores with more complex and validated instruments assessing disease-specific burden like Sino-Nasal Outcome Test (SNOT)-22...
2018: Clinical and Translational Allergy
I J Skypala, N W de Jong, E Angier, J Gardner, I Kull, D Ryan, C Venter, B J Vlieg-Boerstra, K Grimshaw
The multi-disciplinary team approach is an effective model for patient care. Allied health professionals (AHPs) are an important part of such teams, bringing specific knowledge and skills related to the target patient population. The AHPs most often involved in allergy care are nurses and dietitians. Nurses are often involved in the care of patients with all types of allergy and also with asthma, whilst allergy-specialist dietitians provide vital nutritional and dietary support for the diagnosis and management of food allergy...
2018: Clinical and Translational Allergy
Jinyan Yu, Xiaoqiu Liu, Yanlei Li, Shanshan Meng, Fei Wu, Bingdi Yan, Yanjun Xue, Tiangang Ma, Junling Yang, Jing Liu
Background: As the development of urbanization in China, the morbidity of allergic disease rise up prominently even in children, which may be partially associated with the excessively clean environment. It has been reported that common microorganism in rural environment shows protective effects on allergic disease by modulating TLRs-Tregs/Th cell axis. But the mechanism of this protection still needs to be elucidated in detail. We investigated the effects of maternal exposure to farming environment on the neonatal innate immune system, especially on the TLR-Treg-Th (Th1, Th2, Th9, and Th17) axis, in the Jilin province of China...
2018: Clinical and Translational Allergy
Jaap Akkerdaas, Muriel Totis, Brian Barnett, Erin Bell, Tom Davis, Thomas Edrington, Kevin Glenn, Gerson Graser, Rod Herman, Andre Knulst, Gregory Ladics, Scott McClain, Lars K Poulsen, Rakesh Ranjan, Jean-Baptiste Rascle, Hector Serrano, Dave Speijer, Rong Wang, Lucilia Pereira Mouriès, Annabelle Capt, Ronald van Ree
Background: Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions encountered in representative food consumption scenarios. Aim: To evaluate whether inclusion of more physiological conditions, such as sub-optimal and lower pepsin concentrations, in combination with pancreatin digestion, improved the performance of digestibility protocols used in characterization of protein stability...
2018: Clinical and Translational Allergy
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