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Clinical and Translational Allergy

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https://www.readbyqxmd.com/read/27895895/allergy-immunotherapy-across-the-life-cycle-to-promote-active-and-healthy-ageing-from-research-to-policies-an-airways-integrated-care-pathways-icps-programme-item-action-plan-b3-of-the-european-innovation-partnership-on-active-and-healthy-ageing-and-the-global
#1
REVIEW
M A Calderon, P Demoly, T Casale, C A Akdis, C Bachert, M Bewick, B M Bilò, B Bohle, S Bonini, A Bush, D P Caimmi, G W Canonica, V Cardona, A M Chiriac, L Cox, A Custovic, F De Blay, P Devillier, A Didier, G Di Lorenzo, G Du Toit, S R Durham, P Eng, A Fiocchi, A T Fox, R Gerth van Wijk, R M Gomez, T Haathela, S Halken, P W Hellings, L Jacobsen, J Just, L K Tanno, J Kleine-Tebbe, L Klimek, E F Knol, P Kuna, D E Larenas-Linnemann, A Linneberg, M Matricardi, H J Malling, R Moesges, J Mullol, A Muraro, N Papadopoulos, G Passalacqua, E Pastorello, O Pfaar, D Price, P Rodriguez Del Rio, R Ruëff, B Samolinski, G K Scadding, G Senti, M H Shamji, A Sheikh, J C Sisul, D Sole, G J Sturm, A Tabar, R Van Ree, M T Ventura, C Vidal, E M Varga, M Worm, T Zuberbier, J Bousquet
Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27891215/hypothesis-may-e-cigarette-smoking-boost-the-allergic-epidemic
#2
EDITORIAL
Jean Bousquet, Claus Bachert, Laura Crotty Alexander, Frank T Leone
No abstract text is available yet for this article.
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27826414/standardization-of-double-blind-placebo-controlled-food-challenge-with-soy-within-a-multicentre-trial
#3
R Treudler, A Franke, A Schmiedeknecht, B K Ballmer-Weber, M Worm, T Werfel, U Jappe, T Biedermann, J Schmitt, R Brehler, A Kleinheinz, J Kleine-Tebbe, H Brüning, F Ruëff, J Ring, J Saloga, K Schäkel, T Holzhauser, St Vieths, J C Simon
BACKGROUND: Multicentre trials investigating food allergies by double blind placebo controlled food challenges (DBPCFC) need standardized procedures, challenge meals and evaluation criteria. We aimed at developing a standardized approach for identifying patients with birch related soy allergy by means of DBPCFC to soy, including determination of threshold levels, in a multicentre setting. METHODS: Microbiologically stable soy challenge meals were composed of protein isolate with consistent Gly m 4 levels...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27733903/impaired-health-related-quality-of-life-in-adolescents-with-allergy-to-staple-foods
#4
Jennifer Lisa Penner Protudjer, Sven-Arne Jansson, Roelinde Middelveld, Eva Östblom, Sven-Erik Dahlén, Marianne Heibert Arnlind, Ulf Bengtsson, Ingrid Kallström-Bengtsson, Birgitta Marklund, Georgios Rentzos, Ann-Charlotte Sundqvist, Johanna Åkerström, Staffan Ahlstedt
BACKGROUND: Cow's milk, hen's egg and wheat are staple foods in a typical western diet. Despite the ubiquity of these foods, the impact of staple food allergy on health-related quality of life (HRQL) amongst adolescents is incompletely understood. The aims of this study were to make use of the Swedish version of EuroPrevall's disease-specific food allergy quality of life questionnaire-teenager form (FAQLQ-TF) and to investigate the association between objectively-diagnosed staple food allergy and HRQL amongst adolescents...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27688875/proficiency-testing-of-skin-prick-testers-as-part-of-a-quality-assurance-system
#5
Hans-Jørgen Malling, Pernille Allesen-Holm, Lisbeth Sys Karved, Lars K Poulsen
BACKGROUND: Skin prick test is an important diagnostic procedure in clinical allergy but documentation of the quality is often missing. METHODS: We describe a proficiency system to evaluate staff members in relation to the international recommended reproducibility in terms of coefficient of variation (CV < 40 %) and the linearity (coefficient of regression >0.85) based on blinded octuplicate histamine testing using histamine 3, 10, 30 and 100 mg/ml. RESULTS: Fourteen trained allergy nurses participated in the proficiency testing...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27610217/cost-utility-analysis-of-the-sq-%C3%A2-hdm-slit-tablet-in-house-dust-mite-allergic-asthma-patients-in-a-german-setting
#6
J Hahn-Pedersen, M Worm, W Green, J Nørgaard Andreasen, M Taylor
BACKGROUND: Asthma affects an estimated 300 million people worldwide with the condition associated with significant healthcare utilisation costs and a large impact on patient quality of life. The SQ(®) HDM SLIT-tablet (ACARIZAX(®), Hørsholm, Denmark) is a sublingually administered allergy immunotherapy tablet for house dust mite allergic asthma and allergic rhinitis and has recently been licensed in Europe. OBJECTIVE: To assess the cost-effectiveness of ACARIZAX plus pharmacotherapy versus placebo plus pharmacotherapy in patients with house dust mite allergic asthma that is uncontrolled by inhaled corticosteroids, in a German setting...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27583128/a-qualitative-study-of-the-allergy-testing-experiences-views-and-preferences-of-adult-patients
#7
Clare E Brown, Christina J Jones, Laura Stuttaford, Annalee Robertson, Rabia S Rashid, Helen E Smith
BACKGROUND: Patients can be tested for IgE sensitivities with in vivo or in vitro testing, but patients' experiences of different allergy test modalities have not been studied. The objective of this study was to investigate adult patients' experiences, views and preferences for allergy testing, exploring skin prick testing and allergen-specific IgE testing. METHODS: A qualitative study of adults attending out-patients for investigation of a suspected allergy. A purposive, convenience sample identified participants and semi-structured interviews were conducted, face to face or by telephone...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27559467/body-mass-index-and-physical-activity-in-early-childhood-are-associated-with-atopic-sensitization-atopic-dermatitis-and-asthma-in-later-childhood
#8
Kristine Kjer Byberg, Geir Egil Eide, Michele R Forman, Pétur Benedikt Júlíusson, Knut Øymar
BACKGROUND: The results of studies on the associations of childhood excessive weight/obesity and physical activity with atopic sensitization and atopic diseases are inconsistent. We studied the associations of anthropometry and physical activity in childhood with atopic sensitization and atopic diseases in late childhood. METHODS: In a cohort study including cases exposed to preeclampsia during pregnancy and controls, anthropometry and physical activity were assessed at several ages in 617 children...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27540466/improvement-of-sleep-in-patients-with-chronic-idiopathic-spontaneous-urticaria-treated-with-omalizumab-results-of-three-randomized-double-blind-placebo-controlled-studies
#9
Ana M Gimenéz-Arnau, Sheldon Spector, Evgeniya Antonova, Benjamin Trzaskoma, Karin Rosén, Theodore A Omachi, Donald Stull, Maria-Magdalena Balp, Thomas Murphy
BACKGROUND: Patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) report difficulty with sleep. METHODS: We examined the effect of omalizumab on sleep-related outcomes during 3-6 months omalizumab or placebo treatment and a 16-week follow-up period within three Phase III double-blind randomized placebo-controlled pivotal trials in CIU/CSU: ASTERIA I, ASTERIA II, and GLACIAL. Sleep quality was assessed in all three studies using sleep-related questions included in an electronic diary, the Chronic Urticaria Quality of Life Questionnaire, and the Medical Outcomes Study Sleep Scale...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27493721/different-risk-factor-patterns-for-adult-asthma-rhinitis-and-eczema-results-from-west-sweden-asthma-study
#10
Erik P Rönmark, Linda Ekerljung, Roxana Mincheva, Sigrid Sjölander, Stig Hagstad, Göran Wennergren, Eva Rönmark, Jan Lötvall, Bo Lundbäck
BACKGROUND: Atopic diseases including asthma, rhinitis and eczema have increased in the second half of the past century. This has been well studied among children and adolescents but with the exception of asthma to a much lesser extent in adults. The adult risk factor pattern of atopic diseases, in particular of eczema, and their relation to allergic sensitization are yet to be fully elucidated. Studies among adults that have compared the risk factor pattern for these conditions in the same material are very few...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27478588/scaling-up-strategies-of-the-chronic-respiratory-disease-programme-of-the-european-innovation-partnership-on-active-and-healthy-ageing-action-plan-b3-area-5
#11
REVIEW
J Bousquet, J Farrell, G Crooks, P Hellings, E H Bel, M Bewick, N H Chavannes, J Correia de Sousa, A A Cruz, T Haahtela, G Joos, N Khaltaev, J Malva, A Muraro, M Nogues, S Palkonen, S Pedersen, C Robalo-Cordeiro, B Samolinski, T Strandberg, A Valiulis, A Yorgancioglu, T Zuberbier, A Bedbrook, W Aberer, M Adachi, A Agusti, C A Akdis, M Akdis, J Ankri, A Alonso, I Annesi-Maesano, I J Ansotegui, J M Anto, S Arnavielhe, H Arshad, C Bai, I Baiardini, C Bachert, A K Baigenzhin, C Barbara, E D Bateman, B Beghé, A Ben Kheder, K S Bennoor, M Benson, K C Bergmann, T Bieber, C Bindslev-Jensen, L Bjermer, H Blain, F Blasi, A L Boner, M Bonini, S Bonini, S Bosnic-Anticevitch, L P Boulet, R Bourret, P J Bousquet, F Braido, A H Briggs, C E Brightling, J Brozek, R Buhl, P G Burney, A Bush, F Caballero-Fonseca, D Caimmi, M A Calderon, P M Calverley, P A M Camargos, G W Canonica, T Camuzat, K H Carlsen, W Carr, A Carriazo, T Casale, A M Cepeda Sarabia, L Chatzi, Y Z Chen, R Chiron, E Chkhartishvili, A G Chuchalin, K F Chung, G Ciprandi, I Cirule, L Cox, D J Costa, A Custovic, R Dahl, S E Dahlen, U Darsow, G De Carlo, F De Blay, T Dedeu, D Deleanu, E De Manuel Keenoy, P Demoly, J A Denburg, P Devillier, A Didier, A T Dinh-Xuan, R Djukanovic, D Dokic, H Douagui, G Dray, R Dubakiene, S R Durham, M S Dykewicz, Y El-Gamal, R Emuzyte, L M Fabbri, M Fletcher, A Fiocchi, A Fink Wagner, J Fonseca, W J Fokkens, F Forastiere, P Frith, M Gaga, A Gamkrelidze, J Garces, J Garcia-Aymerich, B Gemicioğlu, J E Gereda, S González Diaz, M Gotua, I Grisle, L Grouse, Z Gutter, M A Guzmán, L G Heaney, B Hellquist-Dahl, D Henderson, A Hendry, J Heinrich, D Heve, F Horak, J O' B Hourihane, P Howarth, M Humbert, M E Hyland, M Illario, J C Ivancevich, J R Jardim, E J Jares, C Jeandel, C Jenkins, S L Johnston, O Jonquet, K Julge, K S Jung, J Just, I Kaidashev, M R Kaitov, O Kalayci, A F Kalyoncu, T Keil, P K Keith, L Klimek, B Koffi N'Goran, V Kolek, G H Koppelman, M L Kowalski, I Kull, P Kuna, V Kvedariene, B Lambrecht, S Lau, D Larenas-Linnemann, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K Lodrup Carlsen, R Louis, W MacNee, Y Magard, A Magnan, B Mahboub, A Mair, I Majer, M J Makela, P Manning, S Mara, G D Marshall, M R Masjedi, P Matignon, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O Meltzer, A Menzies-Gow, H Merk, J P Michel, N Miculinic, F Mihaltan, B Milenkovic, G M Y Mohammad, M Molimard, I Momas, A Montilla-Santana, M Morais-Almeida, M Morgan, R Mösges, J Mullol, S Nafti, L Namazova-Baranova, R Naclerio, A Neou, H Neffen, K Nekam, B Niggemann, G Ninot, T D Nyembue, R E O'Hehir, K Ohta, Y Okamoto, K Okubo, S Ouedraogo, P Paggiaro, I Pali-Schöll, P Panzner, N Papadopoulos, A Papi, H S Park, G Passalacqua, I Pavord, R Pawankar, R Pengelly, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, D Poethig, W Pohl, T A Popov, F Portejoie, P Potter, D Postma, D Price, K F Rabe, F Raciborski, F Radier Pontal, S Repka-Ramirez, S Reitamo, S Rennard, F Rodenas, J Roberts, J Roca, L Rodriguez Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, L Rosenwasser, M Rottem, D Ryan, M Sanchez-Borges, G K Scadding, H J Schunemann, E Serrano, P Schmid-Grendelmeier, H Schulz, A Sheikh, M Shields, N Siafakas, Y Sibille, T Similowski, F E R Simons, J C Sisul, I Skrindo, H A Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J Sterk, J Sunyer, C Thijs, T To, A Todo-Bom, M Triggiani, R Valenta, A L Valero, E Valia, E Valovirta, E Van Ganse, M van Hage, O Vandenplas, T Vasankari, B Vellas, J Vestbo, G Vezzani, P Vichyanond, G Viegi, C Vogelmeier, T Vontetsianos, M Wagenmann, B Wallaert, S Walker, D Y Wang, U Wahn, M Wickman, D M Williams, S Williams, J Wright, B P Yawn, P K Yiallouros, O M Yusuf, A Zaidi, H J Zar, M E Zernotti, L Zhang, N Zhong, M Zidarn, J Mercier
Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27453775/atopic-dermatitis-prevention-in-children-following-maternal-probiotic-supplementation-does-not-appear-to-be-mediated-by-breast-milk-tslp-or-tgf-%C3%AE
#12
Melanie Rae Simpson, Anne Dorthea Bjerkenes Rø, Øystein Grimstad, Roar Johnsen, Ola Storrø, Torbjørn Øien
BACKGROUND: The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence of atopic dermatitis (AD) in infancy. The mechanisms behind this effect are incompletely understood and breast milk cytokines have been postulated as possible mediating factors. In this study we aimed to assess whether breast milk TLSP and TGF-β are affected by a maternal probiotic supplementation regime, and their contribution to the preventive effect of this regime on AD in the offspring...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27446529/optimizing-diagnostic-tests-for-persulphate-induced-respiratory-diseases
#13
M H Foss-Skiftesvik, L Winther, H F Mosbech, P S Skov, M S Opstrup, H Søsted, C Zachariae, J D Johansen, C R Johnsen
BACKGROUND: Persulphates from hair bleaching products are considered the major cause of occupational-rhinitis and asthma in hairdressers. The specific inhalation challenge (SIC) is considered 'reference standard' for diagnosing persulphate-induced asthma and rhinitis; however, the currently validated method of performing SIC with persulphate powder is time consuming with a duration of up to 4 days. The value of skin prick tests (SPTs) and histamine release tests (HRTs) with persulphates is unknown...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27418957/the-impact-of-the-elimination-diet-on-growth-and-nutrient-intake-in-children-with-food-protein-induced-gastrointestinal-allergies
#14
Rosan Meyer, Claire De Koker, Robert Dziubak, Heather Godwin, Gloria Dominguez-Ortega, Adriana Chebar Lozinsky, Ana-Kristina Skrapac, Yara Gholmie, Kate Reeve, Neil Shah
BACKGROUND: Non immunoglobulin E (IgE) mediated allergies affecting the gastrointestinal tract require an elimination diet to aid diagnosis. The elimination diet may entail multiple food eliminations that contribute significantly to macro- and micro-nutrient intake which are essential for normal growth and development. Previous studies have indicated growth faltering in children with IgE-mediated allergy, but limited data is available on those with delayed type allergies. We therefore performed a study to establish the impact on growth before and after commencing an elimination diets in children with food protein induced non-IgE mediated gastrointestinal allergies...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27382460/allergen-immunotherapy-for-ige-mediated-food-allergy-protocol-for-a-systematic-review
#15
Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27358726/influence-of-profilin-on-sensitisation-profiles-determined-by-cutaneous-tests-and-ige-to-major-allergens-in-polysensitised-patients
#16
Nieves Segura, Teresa Abos, José A Compaired, Esther Compés, Isabel Guallar, Manuel Morales, Susana Monzón, José Mozota, Pilar Muñoz, Jesús Pola, Macarena Quintana, Beatriz Rojas, Sara San Juan, Felicitas Villa, Cristina Zapata, Lucía Jimeno, Fernando de la Torre
BACKGROUND: Profilin sensitisation is considered a diagnostic confounding factor in areas where patients are exposed to multiple pollens. The aim of this study is to assess pollen sensitisation profiles in adults and children and to evaluate, by means of component-resolved diagnosis (CRD) and skin prick testing (SPT), which pollens may be considered as risk factors of profilin sensitisation in order to establish the best diagnostic approach in polysensitised patients. METHODS: A total of 231 pollen-allergic patients (adults and children) were included, out of the pollen season, from an area with similar levels of pollen exposure...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27335632/very-low-prevalence-of-ige-mediated-wheat-allergy-and-high-levels-of-cross-sensitisation-between-grass-and-wheat-in-a-uk-birth-cohort
#17
Carina Venter, Kate Maslin, Syed Hasan Arshad, Veeresh Patil, Jane Grundy, Gillian Glasbey, Roger Twiselton, Taraneh Dean
BACKGROUND: Patients often report adverse reactions to wheat. Interpretation of sensitization to wheat pollen and flour with/without sensitization to grass pollen is a clinical problem. AIM: We set out to determine the prevalence of wheat allergy in a birth cohort (10/11 year olds) and investigate the usefulness of performing skin prick tests (SPT), specific IgE tests and component resolved diagnostics to wheat pollen and flour. METHODS: The Food Allergy and Intolerance Research (FAIR) birth cohort included babies born on the Isle of Wight (UK) between September 2001-August 2002 (n = 969)...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27313841/current-challenges-facing-the-assessment-of-the-allergenic-capacity-of-food-allergens-in-animal-models
#18
REVIEW
Katrine Lindholm Bøgh, Jolanda van Bilsen, Robert Głogowski, Iván López-Expósito, Grégory Bouchaud, Carine Blanchard, Marie Bodinier, Joost Smit, Raymond Pieters, Shanna Bastiaan-Net, Nicole de Wit, Eva Untersmayr, Karine Adel-Patient, Leon Knippels, Michelle M Epstein, Mario Noti, Unni Cecilie Nygaard, Ian Kimber, Kitty Verhoeckx, Liam O'Mahony
Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of new protein sources into the diet, such as newly developed innovative foods or foods produced using new technologies and production processes, insects, algae, duckweed, or agricultural products from third countries, creates the opportunity for development of new food allergies, and this in turn has driven the need to develop test methods capable of characterizing the allergenic potential of novel food proteins...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27257475/nutritional-adequacy-of-a-cows-milk-exclusion-diet-in-infancy
#19
Kate Maslin, Erin M Oliver, Karen S Scally, Josh Atkinson, Keith Foote, Carina Venter, Graham Roberts, Kate E C Grimshaw
BACKGROUND: Infants with suspected cows' milk allergy are required to follow a strict milk exclusion diet which may lead to nutritional deficiencies, especially if not supervised by a healthcare professional. The aim of this study was to assess the nutritional adequacy of a cows' milk exclusion diet in a group of UK infants over a period of 6 months. METHODS: Participants in this study are a subgroup of the Prevalence of Infant Food Allergy study, a prospective food allergy birth cohort study from the South of England...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27231527/intralymphatic-immunotherapy-induces-allergen-specific-plasmablasts-and-increases-tolerance-to-skin-prick-testing-in-a-pilot-study
#20
Johannes Martin Schmid, Homaira Nezam, Hans Henrik Torp Madsen, Alexander Schmitz, Hans Jürgen Hoffmann
BACKGROUND: Allergen Immunotherapy is a promising treatment of allergy. Seven patients with rhinoconjunctivitis to grass allergen were treated with intralymphatic immunotherapy (ILIT) to explore whether this treatment could be performed. Effect of treatment was assessed as change in symptom medication score, response in skin prick test and nasal allergen provocation. ILIT deposits allergen in an inguinal lymph node to elicit a strong immune stimulus. This allowed us to monitor appearance of allergen specific plasmablasts 7 days after allergen injection...
2016: Clinical and Translational Allergy
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