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Clinical and Translational Allergy

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https://www.readbyqxmd.com/read/29682277/the-allergic-rhinitis-clinical-investigator-collaborative-ar-cic-verification-of-nasal-allergen-challenge-procedures-in-a-study-utilizing-an-investigational-immunotherapy-for-cat-allergy
#1
Helen Neighbour, Mena Soliman, Lisa M Steacy, Pascal Hickey, Beth Forbes, Mark Larché, Anne K Ellis
Background: The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A key objective of such is the ability to detect efficacy in a small population. AR-CIC sought to test its NAC protocol as a secondary objective in two small mechanistic research trials of a novel form of immunotherapy [Cat Peptide Antigen Desensitisation (Cat-PAD)] for which efficacy had previously been demonstrated...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29636895/pollen-and-spore-monitoring-in-the-world
#2
J T M Buters, C Antunes, A Galveias, K C Bergmann, M Thibaudon, C Galán, C Schmidt-Weber, J Oteros
Background: Ambient air quality monitoring is a governmental duty that is widely carried out in order to detect non-biological ("chemical") components in ambient air, such as particles of < 10 µm (PM10 , PM2.5 ), ozone, sulphur dioxide, and nitrogen oxides. These monitoring networks are publicly funded and air quality data are open to the public. The situation for biological particles that have detrimental effects on health, as is the case of pollen and fungal spores, is however very different...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29599966/effectiveness-of-icatibant-for-treatment-of-hereditary-angioedema-attacks-is-not-affected-by-body-weight-findings-from-the-icatibant-outcome-survey-a-cohort-observational-study
#3
Teresa Caballero, Andrea Zanichelli, Werner Aberer, Marcus Maurer, Hilary J Longhurst, Laurence Bouillet, Irmgard Andresen
Background: Icatibant is a bradykinin B2-receptor antagonist used for the treatment of hereditary angioedema attacks resulting from C1-inhibitor deficiency. Treatment is not adjusted by body weight however the impact of body mass index (BMI) on the effectiveness of icatibant is not documented in the literature. We examined disease characteristics and icatibant treatment effectiveness in patients stratified by BMI in the Icatibant Outcome Survey, an ongoing, international, observational study monitoring the real-world safety and effectiveness of icatibant...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29599965/airborne-protein-concentration-a-key-metric-for-type-1-allergy-risk-assessment-in-home-measurement-challenges-and-considerations
#4
Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie, Stella Cochrane
Background: Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the likelihood that sensitisation will be induced. The main objective of this study was to determine whether airborne concentrations of selected common aeroallergens could be quantified in the air of homes using easily deployable, commercially available equipment and analytical methods, at low levels relevant to risk assessment of the potential to develop respiratory allergies...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29545945/the-kinase-lrrk2-is-differently-expressed-in-chronic-rhinosinusitis-with-and-without-nasal-polyps
#5
Yue Ma, Chunquan Zheng, Le Shi
Background: Chronic rhinosinusitis (CRS), commonly divided into CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) is an inflammatory disease which mechanism remain unclear. Leucine-rich repeat kinase 2 (LRRK2) has been proved to be a negative regulator of inflammation response while its role in pathogenesis of CRS has yet to be revealed. This research study was designed to investigate the relationship between the expression level and biologic role of LRRK2 in CRS. Methods: Expression of LRRK2 mRNA and noncoding repressor of NFAT (NRON) were examined by qRT-PCR...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29515802/on-demand-intermittent-beclomethasone-is-effective-for-mild-asthma-in-brazil
#6
Paulo Camargos, Alessandra Affonso, Geralda Calazans, Lidiana Ramalho, Marisa L Ribeiro, Nulma Jentzsch, Simone Senna, Renato T Stein
Background: Daily inhaled corticosteroids are widely recommended for mild persistent asthma. This study aimed to assess the efficacy of the intermittent use of beclomethasone as an alternative treatment for mild persistent asthma. Methods: In this 16-week trial, children aged 6-18 years were evaluated. Subjects in the continuous treatment arm of the study received 500 μg/day of beclomethasone, whereas the intermittent ones were given 1000 μg/day (250 μg every 6 h) in combination with albuterol for 7 days upon exacerbations or worsening of symptoms...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29484171/publication-trends-of-allergy-pediatric-allergy-and-immunology-and-clinical-and-translational-allergy-journals-a-mesh-term-based-bibliometric-analysis
#7
Daniel Martinho-Dias, Bernardo Sousa-Pinto, Júlio Botelho-Souza, António Soares, Luís Delgado, João Almeida Fonseca
We performed a MeSH term-based bibliometric analysis aiming to assess the publication trends of EAACI journals, namely Allergy, Pediatric Allergy and Immunology (PAI) (from 1990 to 2015) and Clinical and Translational Allergy (CTA) (from its inception in 2011 to 2015). We also aimed to discuss the impact of the creation of CTA in the publication topics of Allergy and PAI. We analysed a total of 1973 articles and 23,660 MeSH terms. Most MeSH terms in the three journals fell in the category of "basic immunology and molecular biology" (BIMB)...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29456832/interleukin-25-and-eosinophils-progenitor-cell-mobilization-in-allergic-asthma
#8
Wei Tang, Steven G Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M Salter, Gail M Gauvreau, Paul M O'Byrne, Roma Sehmi
Background: Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways. Sputum levels of EoP are increased in asthmatics compared to normal controls suggesting an exaggerated eosinophilopoietic environment in the airways. Understanding what factors promote EoP traffic to the airways is important to understand the diathesis of asthma pathology...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29416848/correction-to-better-recognition-diagnosis-and-management-of-non-ige-mediated-cow-s-milk-allergy-in-infancy-imap-an-international-interpretation-of-the-map-milk-allergy-in-primary-care-guideline
#9
Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M Fleischer, Ralf G Heine, Michael Levin, Mario C Vieira, Adam T Fox
[This corrects the article DOI: 10.1186/s13601-017-0162-y.].
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29416847/development-and-validation-of-a-standardized-double-blind-placebo-controlled-food-challenge-matrix-for-raw-hazelnuts
#10
Marjolein Vandekerckhove, Bart Van Droogenbroeck, Marc De Loose, Katleen Coudijzer, Marc Coppens, Philippe Gevaert, Hilde Lapeere
Background: Double-blind, placebo-controlled food challenge (DBPCFC) is considered the gold standard for food allergy diagnosis. However, this test is rarely performed routinely in clinical practice because of various practical issues, e.g. the lack of a standardized matrix preparation. The aim of this study was to develop and validate a convenient DBPCFC matrix, that can easily be implemented in daily clinical practice. The focus of this study was the blinding of hazelnuts, whereby the hazelnuts retained as much as possible their allergenicity and could be mixed homogenously in low-doses to the matrices...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29387340/stevens-johnson-syndrome-toxic-epidermal-necrolysis-and-erythema-multiforme-drug-related-hospitalisations-in-a-national-administrative-database
#11
Bernardo Sousa-Pinto, Luís Araújo, Alberto Freitas, Osvaldo Correia, Luís Delgado
Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrative database, focusing on demographic and clinical characteristics, and in the most frequently implicated drug classes. Methods: We analysed all drug-related hospitalisations with associated diagnosis of SJS/TEN or EM in Portuguese hospitals between 2009 and 2014...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29312657/mi-2-methyl-4-isothiazolin-3-one-contained-in-detergents-is-not-detectable-in-machine-washed-textiles
#12
Maja A Hofmann, Ana Giménez-Arnau, Werner Aberer, Carsten Bindslev-Jensen, Torsten Zuberbier
Background: European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to determine the risk of MI in laundry detergents for household machine washing. Methods: Different formulations of laundry detergents with commercial MI levels, up to one thousand ppm were used and three different types of clothes were washed in a normal household machine setting one time and 10 times...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29299230/european-summit-on-the-prevention-and-self-management-of-chronic-respiratory-diseases-report-of-the-european-union-parliament-summit-29-march-2017
#13
REVIEW
Peter W Hellings, David Borrelli, Sirpa Pietikainen, Ioana Agache, Cezmi Akdis, Claus Bachert, Michael Bewick, Erna Botjes, Jannis Constantinidis, Wytske Fokkens, Tari Haahtela, Claire Hopkins, Maddalena Illario, Guy Joos, Valerie Lund, Antonella Muraro, Benoit Pugin, Sven Seys, David Somekh, Pär Stjärne, Arunas Valiulis, Erkka Valovirta, Jean Bousquet
On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa Pietikainen. The aim of the Summit was to correspond to the needs of the European Commission and of patients suffering from CRD to join forces in Europe for the prevention and self-management. Delegates of the European Rhinologic Society, European Respiratory Society, European Academy of Allergy and Clinical Immunology, European Academy of Paediatrics, and European Patients Organization EFA all lectured on their vision and action plan to join forces in achieving adequate prevention and self-management of CRD in the context of Precision Medicine...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29259760/lung-function-in-severe-pediatric-asthma-a-longitudinal-study-in-children-and-adolescents-in-brazil
#14
Mônica Versiani Nunes Pinheiro de Queiroz, Cristina Gonçalves Alvim, Álvaro A Cruz, Laura Maria de Lima Belizário Facury Lasmar
Background: In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) with severe asthma in Brazil, all of whom were treated with high doses of ICS. We evaluated all spirometry tests together and by ICS dose: 800 and > 800 µg/day. Methods: This was a 3-year longitudinal study in which we analyzed 384 spirometry tests in 65 severe asthma patients (6-18 years of age), divided into two groups by the dose of ICS (budesonide or equivalent): 800 and > 800 µg/day...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29238519/how-to-manage-anaphylaxis-in-primary-care
#15
REVIEW
Alberto Alvarez-Perea, Luciana Kase Tanno, María L Baeza
Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different combinations of symptoms and apparently mild signs and can progress to fatal anaphylactic shock unpredictably. The difficulty in recognizing anaphylaxis is due, in part, to the variability of diagnostic criteria, which in turn leads to a delay in administration of appropriate treatment, thus increasing the risk of death...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29225773/is-there-a-sex-shift-in-prevalence-of-allergic-rhinitis-and-comorbid-asthma-from-childhood-to-adulthood-a-meta-analysis
#16
REVIEW
M Fröhlich, M Pinart, T Keller, A Reich, B Cabieses, C Hohmann, D S Postma, J Bousquet, J M Antó, T Keil, S Roll
Background: Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. Methods: Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29214013/prediction-and-prevention-of-allergy-and-asthma-in-eaaci-journals-2016
#17
REVIEW
Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W Hellings, Ioana Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members.
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29214012/evidence-of-the-efficacy-and-safety-of-house-dust-mite-subcutaneous-immunotherapy-in-elderly-allergic-rhinitis-patients-a-randomized-double-blind-placebo-controlled-trial
#18
Andrzej Bożek, Krzysztof Kołodziejczyk, Renata Kozłowska, Giorgio Walter Canonica
Background: Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was to evaluate the safety and efficacy of AIT for house dust mite allergens in patients over 65 years of age with allergic rhinitis (AR) and a documented allergy to house dust mites. The primary endpoint was the change from baseline in the mean average adjusted symptom score (AAdSS) and the total combined rhinitis score (TCRS) difference in the least square means for the label compared to placebo...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29209493/comparison-of-atopy-patch-testing-to-skin-prick-testing-for-diagnosing-mite-induced-atopic-dermatitis-a-systematic-review-and-meta-analysis
#19
REVIEW
Yumei Liu, Jianglong Peng, Ying Zhou, Yubao Cui
Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Methods: A structured search was performed using online databases and bibliographies published as of April 30, 2017...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29201345/sensitization-to-pr-10-proteins-is-indicative-of-distinctive-sensitization-patterns-in-adults-with-a-suspected-food-allergy
#20
Mark A Blankestijn, André C Knulst, Edward F Knol, Thuy-My Le, Heike Rockmann, Henny G Otten, Rob J B Klemans
Background: The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storage protein family, as well as patterns in (co-)sensitization, in a birch-endemic area. Methods: Results of ImmunoCAP ISAC, performed during routine care in Dutch adult outpatients suspected of food allergy, were collected. Results: A total of 305 patients were selected, aged 16-79 years (median 32 years)...
2017: Clinical and Translational Allergy
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