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Clinical and Translational Allergy

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https://www.readbyqxmd.com/read/29238519/how-to-manage-anaphylaxis-in-primary-care
#1
REVIEW
Alberto Alvarez-Perea, Luciana Kase Tanno, María L Baeza
Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different combinations of symptoms and apparently mild signs and can progress to fatal anaphylactic shock unpredictably. The difficulty in recognizing anaphylaxis is due, in part, to the variability of diagnostic criteria, which in turn leads to a delay in administration of appropriate treatment, thus increasing the risk of death...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29225773/is-there-a-sex-shift-in-prevalence-of-allergic-rhinitis-and-comorbid-asthma-from-childhood-to-adulthood-a-meta-analysis
#2
REVIEW
M Fröhlich, M Pinart, T Keller, A Reich, B Cabieses, C Hohmann, D S Postma, J Bousquet, J M Antó, T Keil, S Roll
Background: Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. Methods: Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29214013/prediction-and-prevention-of-allergy-and-asthma-in-eaaci-journals-2016
#3
REVIEW
Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W Hellings, Ioana Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members.
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29214012/evidence-of-the-efficacy-and-safety-of-house-dust-mite-subcutaneous-immunotherapy-in-elderly-allergic-rhinitis-patients-a-randomized-double-blind-placebo-controlled-trial
#4
Andrzej Bożek, Krzysztof Kołodziejczyk, Renata Kozłowska, Giorgio Walter Canonica
Background: Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was to evaluate the safety and efficacy of AIT for house dust mite allergens in patients over 65 years of age with allergic rhinitis (AR) and a documented allergy to house dust mites. The primary endpoint was the change from baseline in the mean average adjusted symptom score (AAdSS) and the total combined rhinitis score (TCRS) difference in the least square means for the label compared to placebo...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29209493/comparison-of-atopy-patch-testing-to-skin-prick-testing-for-diagnosing-mite-induced-atopic-dermatitis-a-systematic-review-and-meta-analysis
#5
REVIEW
Yumei Liu, Jianglong Peng, Ying Zhou, Yubao Cui
Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Methods: A structured search was performed using online databases and bibliographies published as of April 30, 2017...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29201345/sensitization-to-pr-10-proteins-is-indicative-of-distinctive-sensitization-patterns-in-adults-with-a-suspected-food-allergy
#6
Mark A Blankestijn, André C Knulst, Edward F Knol, Thuy-My Le, Heike Rockmann, Henny G Otten, Rob J B Klemans
Background: The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storage protein family, as well as patterns in (co-)sensitization, in a birch-endemic area. Methods: Results of ImmunoCAP ISAC, performed during routine care in Dutch adult outpatients suspected of food allergy, were collected. Results: A total of 305 patients were selected, aged 16-79 years (median 32 years)...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29177030/is-a-positive-intracutaneous-test-induced-by-penicillin-mediated-by-histamine-a-cutaneous-microdialysis-study-in-penicillin-allergic-patients
#7
Line K Tannert, Sidsel Falkencrone, Charlotte G Mortz, Carsten Bindslev-Jensen, Per Stahl Skov
Background: Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective: To investigate real-time histamine release from a positive intracutaneous test induced by penicillin in patients with positive and negative challenges to penicillin...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29152167/differences-in-medication-adherence-are-associated-with-beliefs-about-medicines-in-asthma-and-copd
#8
Susanne Brandstetter, Tamara Finger, Wiebke Fischer, Magdalena Brandl, Merle Böhmer, Michael Pfeifer, Christian Apfelbacher
Adherence to medication is crucial for achieving treatment control in chronic obstructive lung diseases. This study refers to the "necessity-concerns framework" and examines the associations between beliefs about medicines and self-reported medication adherence in people with chronic obstructive lung disease. 402 patients (196 with asthma, 206 with COPD) participated in the study and completed a questionnaire comprising the "Beliefs about Medicines-Questionnaire" (BMQ) and the "Medication Adherence Report Scale" (MARS)...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29118971/local-allergic-rhinitis-evolution-of-concepts
#9
EDITORIAL
Cristoforo Incorvaia, Nicola Fuiano, Irene Martignago, Bruna L Gritti, Erminia Ridolo
The discovery of an exclusive local production of IgE antibodies dates back to the 1970s, but only recently the pathophysiology of such phenomenon was deeply investigated, leading to the concept of local allergic rhinitis (LAR). Currently, LAR is defined by the occurrence, in patients with symptoms clearly suggesting allergic rhinitis but with negative results to common allergy testing, of allergen specific IgE in the nasal mucosa. Most studies investigating LAR were based on the development of rhinitis symptoms following nasal provocation test (NPT) with the suspected allergens, but such test may be performed by a number of options, none of them being as yet acknowledged and recommended in consensus document...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29075437/chrodis-criteria-applied-to-the-mask-macvia-aria-sentinel-network-good-practice-in-allergic-rhinitis-a-sunfrail-report
#10
REVIEW
J Bousquet, G L Onorato, C Bachert, M Barbolini, A Bedbrook, L Bjermer, J Correia de Sousa, N H Chavannes, A A Cruz, E De Manuel Keenoy, P Devillier, J Fonseca, S Hun, T Kostka, P W Hellings, M Illario, J C Ivancevich, D Larenas-Linnemann, J Millot-Keurinck, D Ryan, B Samolinski, A Sheikh, A Yorgancioglu, I Agache, S Arnavielhe, M Bewick, I Annesi-Maesano, J M Anto, K C Bergmann, C Bindslev-Jensen, S Bosnic-Anticevich, J Bouchard, D P Caimmi, P Camargos, G W Canonica, V Cardona, A M Carriazo, C Cingi, E Colgan, A Custovic, R Dahl, P Demoly, G De Vries, W J Fokkens, J F Fontaine, B Gemicioğlu, N Guldemond, Z Gutter, T Haahtela, B Hellqvist-Dahl, E Jares, G Joos, J Just, N Khaltaev, T Keil, L Klimek, M L Kowalski, I Kull, P Kuna, V Kvedariene, D Laune, R Louis, A Magnan, J Malva, E Mathieu-Dupas, E Melén, E Menditto, M Morais-Almeida, R Mösges, J Mullol, R Murray, H Neffen, R O'Hehir, S Palkonen, N G Papadopoulos, G Passalacqua, J L Pépin, F Portejoie, D Price, B Pugin, F Raciborski, F E R Simons, M Sova, O Spranger, C Stellato, A Todo Bom, P V Tomazic, M Triggiani, A Valero, E Valovirta, O VandenPlas, A Valiulis, M van Eerd, M T Ventura, M Wickman, I Young, T Zuberbier, A Zurkuhlen, A Senn
A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29043014/an-open-label-study-to-evaluate-the-long-term-safety-and-efficacy-of-lanadelumab-for-prevention-of-attacks-in-hereditary-angioedema-design-of-the-help-study-extension
#11
Marc A Riedl, Jonathan A Bernstein, Timothy Craig, Aleena Banerji, Markus Magerl, Marco Cicardi, Hilary J Longhurst, Mustafa M Shennak, William H Yang, Jennifer Schranz, Jovanna Baptista, Paula J Busse
BACKGROUND: Hereditary angioedema (HAE) is characterized by recurrent attacks of subcutaneous or submucosal edema. Attacks are unpredictable, debilitating, and have a significant impact on quality of life. Patients may be prescribed prophylactic therapy to prevent angioedema attacks. Current prophylactic treatments may be difficult to administer (i.e., intravenously), require frequent administrations or are not well tolerated, and breakthrough attacks may still occur frequently. Lanadelumab is a subcutaneously-administered monoclonal antibody inhibitor of plasma kallikrein in clinical development for prophylaxis of hereditary angioedema attacks...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29021893/the-efficacy-of-oral-and-subcutaneous-antigen-specific-immunotherapy-in-murine-cow-s-milk-and-peanut-allergy-models
#12
Marlotte M Vonk, Laura Wagenaar, Raymond H H Pieters, Leon M J Knippels, Linette E M Willemsen, Joost J Smit, Betty C A M van Esch, Johan Garssen
BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in murine models for CMA and PNA and determine the dose of allergen needed to effectively modify parameters of allergy. METHODS: Female C3H/HeOuJ mice were sensitized intragastrically (i...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28948011/an-interpretation-of-the-new-international-map-guideline-for-the-management-of-milk-allergy-in-primary-care
#13
EDITORIAL
Paul Netts, Louise J Michaelis
General Practitioners suffer from guideline fatigue. They come fast and furious in many complicated forms. Cow's milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood presenting to primary and secondary care. The early and accurate diagnosis continues to be highlighted in many countries worldwide. International surveys have found that primary care clinicians would like clearer explanations for the options for the diagnosis of CMA and in so doing a means to increase their understanding of management options for both IgE and Non IgE mediated CMA...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28932387/peak-nasal-inspiratory-flow-as-outcome-for-provocation-studies-in-allergen-exposure-chambers-a-ga-2-len-study
#14
Georg Boelke, Uwe Berger, Karl-Christian Bergmann, Carsten Bindslev-Jensen, Jean Bousquet, Julia Gildemeister, Marek Jutel, Oliver Pfaar, Torsten Sehlinger, Torsten Zuberbier
BACKGROUND: The GA(2)LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28932386/erratum-to-allergen-immunotherapy-for-allergic-asthma-protocol-for-a-systematic-review
#15
Sangeeta Dhami, Ulugbek Nurmatov, Ioana Agache, Susanne Lau, Antonella Muraro, Marek Jutel, Graham Roberts, Cezmi Akdis, Matteo Bonini, Moises Calderon, Thomas Casale, Ozlem Cavkaytar, Linda Cox, Pascal Demoly, Breda Flood, Eckard Hamelmann, Kenji Izuhara, Ömer Kalayci, Jörg Kleine-Tebbe, Antonio Nieto, Nikolaos Papadopoulos, Oliver Pfaar, Lanny Rosenwasser, Dermot Ryan, Carsten Schmidt-Weber, Stan Szefler, Ulrich Wahn, Roy-Gerth van Wijk, Jamie Wilkinson, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0094-y.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28932385/erratum-to-allergen-immunotherapy-for-ige-mediated-food-allergy-protocol-for-a-systematic-review
#16
Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0113-z.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28932384/erratum-to-allergen-immunotherapy-for-insect-venom-allergy-protocol-for-a-systematic-review
#17
Sangeeta Dhami, Ulugbek Nurmatov, Eva-Maria Varga, Gunter Sturm, Antonella Muraro, Cezmi A Akdis, Darío Antolín-Amérigo, M Beatrice Bilò, Danijela Bokanovic, Moises A Calderon, Ewa Cichocka-Jarosz, Joanna N G Oude Elberink, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange, Ervin Mingomataj, Dimitris I Mitsias, Holger Mosbech, Oliver Pfaar, Constantinos Pitsios, Valerio Pravettoni, Graham Roberts, Franziska Ruëff, Betül Ayşe Sin, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0095-x.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28932383/erratum-to-allergen-immunotherapy-for-allergic-rhinoconjunctivitis-protocol-for-a-systematic-review
#18
Sangeeta Dhami, Ulugbek Nurmatov, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J Ansotegui, Moises Calderon, Cemal Cingi, Pascal Demoly, Stephen Durham, Ronald Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol, Desiree Larenas Linnemann, Sandra Lin, Vivian Maggina, Hanneke Oude-Elberink, Giovanni Pajno, Ruby Panwankar, Elideanna Pastorello, Constantinos Pitsios, Giuseppina Rotiroti, Frans Timmermans, Olympia Tsilochristou, Eva-Maria Varga, Jamie Wilkinson, Andrew Williams, Margitta Worm, Luo Zhang, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0099-6.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28861213/idiopathic-non-histaminergic-acquired-angioedema-a-case-series-and-discussion-of-published-clinical-trials
#19
Martin Christian Bucher, Tatjana Petkovic, Arthur Helbling, Urs Christian Steiner
BACKGROUND: Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatment options have been proposed. In this paper, we have evaluated the most effective therapies for InH-AAE on the basis of current literature and report the therapeutic effect of omalizumab in three patients with InH-AAE. METHODS: Literature was searched with a combination of MeSH/EMTREE terms and freetext search for angioedema and therapy/omalizumab in the databases Medline (Ovid), PubMed/Premedline, Embase, Cochrane library and Scopus with no time or language restrictions...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28852472/better-recognition-diagnosis-and-management-of-non-ige-mediated-cow-s-milk-allergy-in-infancy-imap-an-international-interpretation-of-the-map-milk-allergy-in-primary-care-guideline
#20
REVIEW
Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M Fleischer, Ralf G Heine, Michael Levin, Mario C Vieira, Adam T Fox
Cow's milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood. It is also one of the most complex food allergies, being implicated in IgE-mediated food allergy as well as diverse manifestations of non-IgE-mediated food allergy. For example, gastrointestinal CMA may present as food protein induced enteropathy, enterocolitis or proctocolitis. Concerns regarding the early and timely diagnosis of CMA have been highlighted over the years. In response to these, guideline papers from the United Kingdom (UK), Australia, Europe, the Americas and the World Allergy Organisation have been published...
2017: Clinical and Translational Allergy
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