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Clinical and Translational Allergy

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https://www.readbyqxmd.com/read/30079223/assessing-severity-of-anaphylaxis-a-data-driven-comparison-of-23-instruments
#1
Esben Eller, Antonella Muraro, Ronald Dahl, Charlotte Gotthard Mortz, Carsten Bindslev-Jensen
Backgroud: The severity of an allergic reaction can range from mild local symptoms to anaphylactic shock. To score this, a number of instruments have been developed, although heterogeneous in design and purpose. Severity scoring algorithms are therefore difficult to compare, but are frequently used beyond their initial purpose. Our objective was to compare the most used severity scoring instruments by a data-driven approach on both milder reactions and anaphylaxis. Methods: All positive challenges to foods or drugs (n = 2828) including anaphylaxis (n = 616) at Odense University Hospital, Denmark from 1998 to 2016 were included and severity was scored according to Sampson5...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/30026908/anti-ige-therapy-for-ige-mediated-allergic-diseases-from-neutralizing-ige-antibodies-to-eliminating-ige-b-cells
#2
REVIEW
Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun, Kunmei Ji
Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE plays a vital role in the development of acute allergic reactions and chronic inflammatory allergic diseases, making its control particularly important in the treatment of IgE-mediated allergic diseases. This review provides an overview of the current state of IgE targeted therapy development, focusing on three areas of translational research: IgE neutralization in blood; IgE-effector cell elimination; and IgE+ B cell reduction...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/30002811/severity-of-allergic-rhinitis-impacts-sleep-and-anxiety-results-from-a-large-spanish-cohort
#3
R Muñoz-Cano, P Ribó, G Araujo, E Giralt, J Sanchez-Lopez, A Valero
Background: Allergic rhinitis (AR) is a highly prevalent disease that generates high social and health care costs and also has a significant effect on quality of life and quality of sleep. It has also been related to some psychological disorders like anxiety or depression. Objective: To evaluate anxiety, depression, and quality of sleep and life alteration in a group of patients with perennial AR compared to a group of seasonal AR patients. Methods: Six-hundred seventy adults (> 18 years) with perennial and seasonal AR were recruited consecutively in 47 centers in Spain...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29997888/early-nonreactivity-in-the-conjunctival-provocation-test-predicts-beneficial-outcome-of-sublingual-immunotherapy
#4
Janina Köther, Alicia Mandl, Silke Allekotte, Anatoli Astvatsatourov, Janin Chwieralski, Jan-Patrick Liedtke, Ursula Pieper-Fürst, Esther Raskopf, Kija Shah-Hosseini, Ralph Mösges
Background: Clinical practice needs a common parameter that can provide an early, reliable estimation of the outcome of sublingual immunotherapy (SLIT) in an upcoming pollen season. We investigated whether the conjunctival provocation test (CPT) can predict the beneficial outcome of SLIT in patients with allergic rhinoconjunctivitis after 4 weeks of treatment. Methods: We conducted two separate prospective, randomized, double-blind, placebo-controlled, multicenter trials...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29997887/the-impact-of-cold-on-the-respiratory-tract-and-its-consequences-to-respiratory-health
#5
REVIEW
Maria D'Amato, Antonio Molino, Giovanna Calabrese, Lorenzo Cecchi, Isabella Annesi-Maesano, Gennaro D'Amato
The increasing use, and sometimes the abuse, particularly in industrialized countries of air conditioning at home, in car, hotel and shopping centres has highlighted new emerging public health issues, resulting from exposure of the airways to cool air or, more properly, resulting from sudden temperature changes. This is part of a wider problem, relating to air quality in indoor environment, such as homes or offices, where people spend more than 90% of their time. In particular, if indoor exposure occurs quickly and without any gradual adaptation to a temperature 2°-3° lower than the external temperature and especially with a 5° difference (avoiding indoor temperature below 24°) and an humidity between 40 and 60%, there is a risk of negative consequences on the respiratory tract and the patient risks to be in a clinical condition characterized by an exacerbation of the respiratory symptoms of his chronic respiratory disease (asthma and COPD) within a few hours or days...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29988550/sinus-computed-tomography-predicts-clinical-response-to-corticosteroids-in-chronic-rhinosinusitis-with-nasal-polyps
#6
Haiyu Hong, Dan Wang, Kai Sen Tan, Rui Zheng, Fenghong Chen, Wenxiang Gao, Haixin He, Jianbo Shi, Yunping Fan, Qintai Yang, Yueqi Sun
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study was to evaluate the diagnostic values of sinus computed tomography (CT) for GC-sensitivity in patients with CRSwNP. Methods: We conducted a prospective, single-blinded study of 47 consecutive patients with CRSwNP...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29983907/rapid-onset-of-action-and-reduced-nasal-hyperreactivity-new-targets-in-allergic-rhinitis-management
#7
REVIEW
C Bachert, J Bousquet, P Hellings
Background: This article summarizes a EUFOREA symposium, presented during the European Rhinology Research Forum in Brussels (9-10 November 2017; https://www.rhinologyresearch.eu/) which focused on novel pathways and therapeutic approaches in allergic rhinitis (AR). Main body: AR remains under-diagnosed, under-estimated and under-treated. A key component in understanding the AR landscape has been the realization of a significant mismatch between how physicians instruct AR patients to manage their disease and what AR patients actually do in real life...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29946417/epidemiology-of-spider-mite-sensitivity-a-meta-analysis-and-systematic-review
#8
REVIEW
Ying Zhou, Haoyuan Jia, Xuming Zhou, Yubao Cui, Jun Qian
Background: Spider mites, including Tetranychus urticae , Panonychus citri , and Panonychus ulmi , are common pests in gardens, greenhouses, and orchards. Exposure, particularly occupational exposure, to these organisms may lead to the development of respiratory or contact allergies. However, the prevalence of sensitivity to spider mites is unclear. Methods: We examined the literature to generate an estimate of the global prevalence of allergies to spider mites...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29942488/tonsillar-cytokine-expression-between-patients-with-tonsillar-hypertrophy-and-recurrent-tonsillitis
#9
Emilia Mikola, Varpu Elenius, Maria Saarinen, Oscar Palomares, Matti Waris, Riitta Turunen, Tuomo Puhakka, Lotta Ivaska, Beate Rückert, Alar Aab, Tero Vahlberg, Tytti Vuorinen, Tobias Allander, Carlos A Camargo, Mübeccel Akdis, Cezmi A Akdis, Tuomas Jartti
Background: Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis. Methods: Tonsils of 89 surgical patients with tonsillar hypertrophy (n = 47) or recurrent tonsillitis (n = 42) were analysed...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29881542/cross-sectional-study-on-sensitization-to-mite-and-cockroach-allergen-components-in-allergy-patients-in-the-central-european-region
#10
Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská, Marek Malý
Background: The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite and cockroach allergens in Central Europe has not been established yet. Methods: We assessed sensitization profiles of allergy patients in a Central European region in regard to sensitization to mites and cockroach...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29872524/the-feasibility-of-an-allergy-management-support-system-amss-for-ige-mediated-allergy-in-primary-care
#11
Bertine M J Flokstra-de Blok, Thecla M Brakel, Marian Wubs, Ben Skidmore, Janwillem W H Kocks, Joanne N G Oude Elberink, Marie-Louise A Schuttelaar, Jantina L van der Velde, Thys van der Molen, Anthony E J Dubois
Background: The allergy management support system (AMSS) was developed to assist general practitioners (GPs) to handle the increasing burden of allergic diseases and facilitates the diagnosis and management of allergy. The aim of this cluster-randomized controlled pilot study was to test the feasibility of this AMSS for primary care. Methods: GPs received diagnostic and management recommendations generated by the AMSS in addition to sIgE-test results (intervention) or GPs received sIgE-test results only (control)...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29760877/an-eaaci-task-force-report-recognising-the-potential-of-the-primary-care-physician-in-the-diagnosis-and-management-of-drug-hypersensitivity
#12
REVIEW
I Doña, J C Caubet, K Brockow, M Doyle, E Moreno, I Terreehorst, M J Torres
Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated (allergy) or non-immunologically mediated. The high number of DHRs that are unconfirmed and often self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29755730/having-concomitant-asthma-phenotypes-is-common-and-independently-relates-to-poor-lung-function-in-nhanes-2007-2012
#13
Rita Amaral, João A Fonseca, Tiago Jacinto, Ana M Pereira, Andrei Malinovschi, Christer Janson, Kjell Alving
Background: Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Methods: Data from the National Health and Nutrition Examination Surveys (NHANES) 2007-2012 were used (n = 30,442). Adults with current asthma were selected...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29719717/consideration-of-methods-for-identifying-mite-allergens
#14
REVIEW
Yubao Cui, Qiong Wang, Haoyuan Jia
House dust mites are small arthropods that produce proteins-found in their feces, body parts, and eggs-that are major triggers of human allergies worldwide. The goal of this review is to describe the current methods used to identify these allergens. A literature search for allergen identification methods employed between 1995 and 2016 revealed multiple techniques that can be broadly grouped into discovery and confirmation phases. The discovery phase employs screening for mite proteins that can bind IgEs in sera from animals or patients allergic to dust mites...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29713456/diverse-expression-of-tnf-%C3%AE-and-ccl27-in-serum-and-blister-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#15
Fang Wang, Yanting Ye, Ze-Yu Luo, Qian Gao, Di-Qing Luo, Xingqi Zhang
Background: The pathogenesis of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is not fully understood. Our previous study reported that chemokine CCL27 was overexpressed in serum of SJS/TEN patients. The objective of this study was to investigate the levels of CCL27 and TNF-α in serum and blister fluid from patients with SJS/TEN during the acute stage or resolution phase. Methods: A total of 27 patients with SJS/TEN and 39 healthy donors were recruited to the study...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29682277/the-allergic-rhinitis-clinical-investigator-collaborative-ar-cic-verification-of-nasal-allergen-challenge-procedures-in-a-study-utilizing-an-investigational-immunotherapy-for-cat-allergy
#16
Helen Neighbour, Mena Soliman, Lisa M Steacy, Pascal Hickey, Beth Forbes, Mark Larché, Anne K Ellis
Background: The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A key objective of such is the ability to detect efficacy in a small population. AR-CIC sought to test its NAC protocol as a secondary objective in two small mechanistic research trials of a novel form of immunotherapy [Cat Peptide Antigen Desensitisation (Cat-PAD)] for which efficacy had previously been demonstrated...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29636895/pollen-and-spore-monitoring-in-the-world
#17
J T M Buters, C Antunes, A Galveias, K C Bergmann, M Thibaudon, C Galán, C Schmidt-Weber, J Oteros
Background: Ambient air quality monitoring is a governmental duty that is widely carried out in order to detect non-biological ("chemical") components in ambient air, such as particles of < 10 µm (PM10 , PM2.5 ), ozone, sulphur dioxide, and nitrogen oxides. These monitoring networks are publicly funded and air quality data are open to the public. The situation for biological particles that have detrimental effects on health, as is the case of pollen and fungal spores, is however very different...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29599966/effectiveness-of-icatibant-for-treatment-of-hereditary-angioedema-attacks-is-not-affected-by-body-weight-findings-from-the-icatibant-outcome-survey-a-cohort-observational-study
#18
Teresa Caballero, Andrea Zanichelli, Werner Aberer, Marcus Maurer, Hilary J Longhurst, Laurence Bouillet, Irmgard Andresen
Background: Icatibant is a bradykinin B2-receptor antagonist used for the treatment of hereditary angioedema attacks resulting from C1-inhibitor deficiency. Treatment is not adjusted by body weight however the impact of body mass index (BMI) on the effectiveness of icatibant is not documented in the literature. We examined disease characteristics and icatibant treatment effectiveness in patients stratified by BMI in the Icatibant Outcome Survey, an ongoing, international, observational study monitoring the real-world safety and effectiveness of icatibant...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29599965/airborne-protein-concentration-a-key-metric-for-type-1-allergy-risk-assessment-in-home-measurement-challenges-and-considerations
#19
Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie, Stella Cochrane
Background: Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the likelihood that sensitisation will be induced. The main objective of this study was to determine whether airborne concentrations of selected common aeroallergens could be quantified in the air of homes using easily deployable, commercially available equipment and analytical methods, at low levels relevant to risk assessment of the potential to develop respiratory allergies...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29545945/the-kinase-lrrk2-is-differently-expressed-in-chronic-rhinosinusitis-with-and-without-nasal-polyps
#20
Yue Ma, Chunquan Zheng, Le Shi
Background: Chronic rhinosinusitis (CRS), commonly divided into CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) is an inflammatory disease which mechanism remain unclear. Leucine-rich repeat kinase 2 (LRRK2) has been proved to be a negative regulator of inflammation response while its role in pathogenesis of CRS has yet to be revealed. This research study was designed to investigate the relationship between the expression level and biologic role of LRRK2 in CRS. Methods: Expression of LRRK2 mRNA and noncoding repressor of NFAT (NRON) were examined by qRT-PCR...
2018: Clinical and Translational Allergy
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