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Clinical and Translational Allergy

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https://www.readbyqxmd.com/read/28649320/food-allergy-in-a-child-with-de-novo-kat6a-mutation
#1
Varpu Elenius, Tuire Lähdesmäki, Marja Hietala, Tuomas Jartti
Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, specific facial features and early feeding problems. However, these feeding problems have not earlier been specified. We present the first reported case of a DBPCFC confirmed food allergy in a child with KAT6A mutation whose feeding problems resolved with elimination diet...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28593040/the-impact-of-penicillin-allergy-labels-on-antibiotic-and-health-care-use-in-primary-care-a-retrospective-cohort-study
#2
Tanly Su, Berna D L Broekhuizen, Theo J M Verheij, Heike Rockmann
BACKGROUND: Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration and readmission. OBJECTIVE: Assess the impact of Pen-A labels on antibiotic and health care use in primary care. METHODS: A retrospective cohort study was conducted in primary care in the Utrecht area, the Netherlands. All patients registered with a penicillin allergy on 31 December 2013 were selected from the General Practitioner Network database...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28572918/multi-morbidities-of-allergic-rhinitis-in-adults-european-academy-of-allergy-and-clinical-immunology-task-force-report
#3
REVIEW
C Cingi, P Gevaert, R Mösges, C Rondon, V Hox, M Rudenko, N B Muluk, G Scadding, F Manole, C Hupin, W J Fokkens, C Akdis, C Bachert, P Demoly, J Mullol, A Muraro, N Papadopoulos, R Pawankar, P Rombaux, E Toskala, L Kalogjera, E Prokopakis, P W Hellings, J Bousquet
This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28546858/quality-indicators-for-the-acute-and-long-term-management-of-anaphylaxis-a-systematic-review
#4
REVIEW
Sangeeta Dhami, Aadam Sheikh, Antonella Muraro, Graham Roberts, Susanne Halken, Monserat Fernandez Rivas, Margitta Worm, Aziz Sheikh
BACKGROUND: The quality of acute and long-term anaphylaxis management is variable and this contributes to the poor outcomes experienced by many patients. Clinical practice guidelines have the potential to improve outcomes, but implementing guideline recommendations in routine practice is challenging. Quality indicators have the potential to support guideline implementation efforts. OBJECTIVE: To identify quality indicators to support the acute and long-term management of anaphylaxis...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28533901/allergic-respiratory-disease-ard-setting-forth-the-basics-proposals-of-an-expert-consensus-report
#5
Ana M Navarro, Julio Delgado, Rosa M Muñoz-Cano, M Teresa Dordal, Antonio Valero, Santiago Quirce
BACKGROUND: The variability of symptoms observed in patients with respiratory allergy often hampers classification based on the criteria proposed in guidelines on rhinitis and asthma. OBJECTIVES: We assessed specific aspects of allergic respiratory disease (ARD) that are not explicitly addressed in the guidelines in order to issue specific recommendations and thus optimize clinical practice. METHODS: Using the Delphi technique, 40 Spanish allergists were surveyed to reach consensus on 71 items related to ARD...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28507730/application-of-the-adverse-outcome-pathway-aop-concept-to-structure-the-available-in-vivo-and-in-vitro-mechanistic-data-for-allergic-sensitization-to-food-proteins
#6
REVIEW
Jolanda H M van Bilsen, Edyta Sienkiewicz-Szłapka, Daniel Lozano-Ojalvo, Linette E M Willemsen, Celia M Antunes, Elena Molina, Joost J Smit, Barbara Wróblewska, Harry J Wichers, Edward F Knol, Gregory S Ladics, Raymond H H Pieters, Sandra Denery-Papini, Yvonne M Vissers, Simona L Bavaro, Colette Larré, Kitty C M Verhoeckx, Erwin L Roggen
BACKGROUND: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28400946/the-state-of-asthma-epidemiology-an-overview-of-systematic-reviews-and-their-quality
#7
Jon Genuneit, Annina M Seibold, Christian J Apfelbacher, George N Konstantinou, Jennifer J Koplin, Stefania La Grutta, Kirsty Logan, Carsten Flohr, Michael R Perkin
BACKGROUND: Recently, we have published an overview of systematic reviews in allergy epidemiology and identified asthma as the most commonly reviewed allergic disease. Building on this work, we aimed to investigate the quality of systematic reviews in asthma using the AMSTAR checklist and to provide a reference for future, more in-depth assessment of the extent of previous knowledge. METHODS: We included all 307 systematic reviews indexed with asthma, including occupational asthma, and/or wheeze from our previous search in PubMed and EMBASE up to December 2014 for systematic reviews on epidemiological research on allergic diseases...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28392912/erratum-to-looking-forward-to-new-targeted-treatments-for-chronic-spontaneous-urticaria
#8
Emek Kocatürk, Marcus Maurer, Martin Metz, Clive Grattan
[This corrects the article DOI: 10.1186/s13601-016-0139-2.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28392911/early-childhood-risk-factors-for-rhinoconjunctivitis-in-adolescence-a-prospective-birth-cohort-study
#9
Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz, Susanne Halken
BACKGROUND: Rhinoconjunctivitis is a global health problem and one of the most common chronic conditions in children. Development of rhinoconjunctivitis depends on both genetic and environmental factors. Many studies have investigated rhinoconjunctivitis, but only few studies have evaluated the risk factors for non-allergic rhinoconjunctivitis in children finding family history of atopic diseases and gender to be of importance. The aim of this study was to investigate possible risk factors in early life for rhinoconjunctivitis, allergic as well as non-allergic, in adolescence...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28321292/low-percentage-of-clinically-relevant-pistachio-nut-and-mango-co-sensitisation-in-cashew-nut-sensitised-children
#10
J P M van der Valk, R El Bouche, R Gerth van Wijk, H de Groot, H J Wichers, A E J Dubois, N W de Jong
BACKGROUND: Cashew nut, pistachio nut and mango belong to the Anacardiaceae family and are botanically related. Therefore, cashew nut sensitised children are frequently advised to eliminate cashew nuts and pistachio nuts from their diet. The 'Improvement of Diagnostic mEthods for ALlergy assessment (IDEAL trial number NTR3572) study showed that cashew nut sensitised children were co-sensitised to pistachio nut in 98% of cases and to mango in 21% of cases. The aim of this follow-up study to IDEAL is to assess the clinical relevance of co-sensitisation to pistachio nut and mango in cashew nut sensitised children...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28293415/approach-to-the-diagnosis-of-drug-hypersensitivity-reactions-similarities-and-differences-between-europe-and-north-america
#11
REVIEW
M J Torres, A Romano, G Celik, P Demoly, D A Khan, E Macy, M Park, K Blumenthal, W Aberer, M Castells, A Barbaud, C Mayorga, P Bonadonna
Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28293414/galectin-3-an-early-predictive-biomarker-of-modulation-of-airway-remodeling-in-patients-with-severe-asthma-treated-with-omalizumab-for-36%C3%A2-months
#12
Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto, Giorgio Walter Canonica
BACKGROUND: Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical and physiologic variables that encompass multiple phenotypes and are treated with nonspecific anti-inflammatory therapies. Based on the modulation of airway remodeling after 12 months of anti-immunoglobulin E (IgE) treatment, we identified two phenotypes (omalizumab responder, OR; and non-omalizumab responder, NOR) and performed morphometric analysis of bronchial biopsy specimens...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28289538/effectiveness-and-safety-of-antihistamines-up-to-fourfold-or-higher-in-treatment-of-chronic-spontaneous-urticaria
#13
Mignon T van den Elzen, Harmieke van Os-Medendorp, Imke van den Brink, Karin van den Hurk, Ouliana I Kouznetsova, Alexander S H J Lokin, Anna-Marijke Laheij-de Boer, Heike Röckmann, Carla A F M Bruijnzeel-Koomen, André C Knulst
BACKGROUND: Treatment with second-generation antihistamines is recommended in patients with chronic spontaneous urticaria (CSU). Some patients remain unresponsive even after up-dosing up to fourfold. Many third line treatment options have limited availability and/or give rise to significant side effects. We investigated effectiveness and safety of antihistamine treatment with dosages up to fourfold and higher. METHODS: This retrospective analysis of patients' records was performed in adult CSU patients suffering wheals and/or angioedema (AE)...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28239450/erratum-to-scaling-up-strategies-of-the-chronic-respiratory-disease-programme-of-the-european-innovation-partnership-on-active-and-healthy-ageing-action-plan-b3-area-5
#14
J Bousquet, J Farrell, G Crooks, P Hellings, E H Bel, M Bewick, N H Chavannes, J Correia de Sousa, A A Cruz, T Haahtela, G Joos, N Khaltaev, J Malva, A Muraro, M Nogues, S Palkonen, S Pedersen, C Robalo-Cordeiro, B Samolinski, T Strandberg, A Valiulis, A Yorgancioglu, T Zuberbier, A Bedbrook, W Aberer, M Adachi, A Agusti, C A Akdis, M Akdis, J Ankri, A Alonso, I Annesi-Maesano, I J Ansotegui, J M Anto, S Arnavielhe, H Arshad, C Bai, I Baiardini, C Bachert, A K Baigenzhin, C Barbara, E D Bateman, B Beghé, A Ben Kheder, K S Bennoor, M Benson, K C Bergmann, T Bieber, C Bindslev-Jensen, L Bjermer, H Blain, F Blasi, A L Boner, M Bonini, S Bonini, S Bosnic-Anticevitch, L P Boulet, R Bourret, P J Bousquet, F Braido, A H Briggs, C E Brightling, J Brozek, R Buhl, P G Burney, A Bush, F Caballero-Fonseca, D Caimmi, M A Calderon, P M Calverley, P A M Camargos, G W Canonica, T Camuzat, K H Carlsen, W Carr, A Carriazo, T Casale, A M Cepeda Sarabia, L Chatzi, Y Z Chen, R Chiron, E Chkhartishvili, A G Chuchalin, K F Chung, G Ciprandi, I Cirule, L Cox, D J Costa, A Custovic, R Dahl, S E Dahlen, U Darsow, G De Carlo, F De Blay, T Dedeu, D Deleanu, E De Manuel Keenoy, P Demoly, J A Denburg, P Devillier, A Didier, A T Dinh-Xuan, R Djukanovic, D Dokic, H Douagui, G Dray, R Dubakiene, S R Durham, M S Dykewicz, Y El-Gamal, R Emuzyte, L M Fabbri, M Fletcher, A Fiocchi, A Fink Wagner, J Fonseca, W J Fokkens, F Forastiere, P Frith, M Gaga, A Gamkrelidze, J Garces, J Garcia-Aymerich, B Gemicioğlu, J E Gereda, S González Diaz, M Gotua, I Grisle, L Grouse, Z Gutter, M A Guzmán, L G Heaney, B Hellquist-Dahl, D Henderson, A Hendry, J Heinrich, D Heve, F Horak, J O' B Hourihane, P Howarth, M Humbert, M E Hyland, M Illario, J C Ivancevich, J R Jardim, E J Jares, C Jeandel, C Jenkins, S L Johnston, O Jonquet, K Julge, K S Jung, J Just, I Kaidashev, M R Khaitov, O Kalayci, A F Kalyoncu, T Keil, P K Keith, L Klimek, B Koffi N'Goran, V Kolek, G H Koppelman, M L Kowalski, I Kull, P Kuna, V Kvedariene, B Lambrecht, S Lau, D Larenas-Linnemann, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K Lodrup Carlsen, R Louis, W MacNee, Y Magard, A Magnan, B Mahboub, A Mair, I Majer, M J Makela, P Manning, S Mara, G D Marshall, M R Masjedi, P Matignon, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O Meltzer, A Menzies-Gow, H Merk, J P Michel, N Miculinic, F Mihaltan, B Milenkovic, G M Y Mohammad, M Molimard, I Momas, A Montilla-Santana, M Morais-Almeida, M Morgan, R Mösges, J Mullol, S Nafti, L Namazova-Baranova, R Naclerio, A Neou, H Neffen, K Nekam, B Niggemann, G Ninot, T D Nyembue, R E O'Hehir, K Ohta, Y Okamoto, K Okubo, S Ouedraogo, P Paggiaro, I Pali-Schöll, P Panzner, N Papadopoulos, A Papi, H S Park, G Passalacqua, I Pavord, R Pawankar, R Pengelly, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, D Poethig, W Pohl, T A Popov, F Portejoie, P Potter, D Postma, D Price, K F Rabe, F Raciborski, F Radier Pontal, S Repka-Ramirez, S Reitamo, S Rennard, F Rodenas, J Roberts, J Roca, L Rodriguez Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, L Rosenwasser, M Rottem, D Ryan, M Sanchez-Borges, G K Scadding, H J Schunemann, E Serrano, P Schmid-Grendelmeier, H Schulz, A Sheikh, M Shields, N Siafakas, Y Sibille, T Similowski, F E R Simons, J C Sisul, I Skrindo, H A Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J Sterk, J Sunyer, C Thijs, T To, A Todo-Bom, M Triggiani, R Valenta, A L Valero, E Valia, E Valovirta, E Van Ganse, M van Hage, O Vandenplas, T Vasankari, B Vellas, J Vestbo, G Vezzani, P Vichyanond, G Viegi, C Vogelmeier, T Vontetsianos, M Wagenmann, B Wallaert, S Walker, D Y Wang, U Wahn, M Wickman, D M Williams, S Williams, J Wright, B P Yawn, P K Yiallouros, O M Yusuf, A Zaidi, H J Zar, M E Zernotti, L Zhang, N Zhong, M Zidarn, J Mercier
[This corrects the article DOI: 10.1186/s13601-016-0116-9.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28149501/is-fruit-and-vegetable-intake-associated-with-asthma-or-chronic-rhino-sinusitis-in-european-adults-results-from-the-global-allergy-and-asthma-network-of-excellence-ga-2-len-survey
#15
Vanessa Garcia-Larsen, Rhonda Arthur, James F Potts, Peter H Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, Ana Todo Bom, Grzegorz Brożek, Joanna Makowska, Marek L Kowalski, Trine Thilsing, Thomas Keil, Paolo M Matricardi, Kjell Torén, Thibaut van Zele, Claus Bachert, Barbara Rymarczyk, Christer Janson, Bertil Forsberg, Ewa Niżankowska-Mogilnicka, Peter G J Burney
BACKGROUND: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. OBJECTIVE: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. METHODS: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA(2)LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28078080/three-cases-of-anaphylaxis-following-injection-of-a-depot-corticosteroid-with-evidence-of-ige-sensitization-to-macrogols-rather-than-the-active-steroid
#16
Nicolaj Brandt, Lene H Garvey, Ulla Bindslev-Jensen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz
We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28078079/looking-forward-to-new-targeted-treatments-for-chronic-spontaneous-urticaria
#17
REVIEW
Emek Kocatürk, Marcus Maurer, Martin Metz, Clive Grattan
The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease. But there is still a hard core of patients who do not tolerate or benefit from existing therapies and who require effective treatment. Novel approaches include the use of currently available drugs off-licence, investigational drugs currently undergoing clinical trials and exploring the potential for therapies directed at pathophysiological targets in CSU...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28050247/aria-2016-care-pathways-implementing-emerging-technologies-for-predictive-medicine-in-rhinitis-and-asthma-across-the-life-cycle
#18
REVIEW
J Bousquet, P W Hellings, I Agache, A Bedbrook, C Bachert, K C Bergmann, M Bewick, C Bindslev-Jensen, S Bosnic-Anticevitch, C Bucca, D P Caimmi, P A M Camargos, G W Canonica, T Casale, N H Chavannes, A A Cruz, G De Carlo, R Dahl, P Demoly, P Devillier, J Fonseca, W J Fokkens, N A Guldemond, T Haahtela, M Illario, J Just, T Keil, L Klimek, P Kuna, D Larenas-Linnemann, M Morais-Almeida, J Mullol, R Murray, R Naclerio, R E O'Hehir, N G Papadopoulos, R Pawankar, P Potter, D Ryan, B Samolinski, H J Schunemann, A Sheikh, F E R Simons, C Stellato, A Todo-Bom, P V Tomazic, A Valiulis, E Valovirta, M T Ventura, M Wickman, I Young, A Yorgancioglu, T Zuberbier, W Aberer, C A Akdis, M Akdis, I Annesi-Maesano, J Ankri, I J Ansotegui, J M Anto, S Arnavielhe, A Asarnoj, H Arshad, F Avolio, I Baiardini, C Barbara, M Barbagallo, E D Bateman, B Beghé, E H Bel, K S Bennoor, M Benson, A Z Białoszewski, T Bieber, L Bjermer, H Blain, F Blasi, A L Boner, M Bonini, S Bonini, I Bosse, J Bouchard, L P Boulet, R Bourret, P J Bousquet, F Braido, A H Briggs, C E Brightling, J Brozek, R Buhl, C Bunu, E Burte, A Bush, F Caballero-Fonseca, M A Calderon, T Camuzat, V Cardona, P Carreiro-Martins, A M Carriazo, K H Carlsen, W Carr, A M Cepeda Sarabia, M Cesari, L Chatzi, R Chiron, T Chivato, E Chkhartishvili, A G Chuchalin, K F Chung, G Ciprandi, J Correia de Sousa, L Cox, G Crooks, A Custovic, S E Dahlen, U Darsow, T Dedeu, D Deleanu, J A Denburg, G De Vries, A Didier, A T Dinh-Xuan, D Dokic, H Douagui, G Dray, R Dubakiene, S R Durham, G Du Toit, M S Dykewicz, P Eklund, Y El-Gamal, E Ellers, R Emuzyte, J Farrell, A Fink Wagner, A Fiocchi, M Fletcher, F Forastiere, M Gaga, A Gamkrelidze, B Gemicioğlu, J E Gereda, R Gerth van Wick, S González Diaz, I Grisle, L Grouse, Z Gutter, M A Guzmán, B Hellquist-Dahl, J Heinrich, F Horak, J O' B Hourihane, M Humbert, M Hyland, G Iaccarino, E J Jares, C Jeandel, S L Johnston, G Joos, O Jonquet, K S Jung, M Jutel, I Kaidashev, M Khaitov, O Kalayci, A F Kalyoncu, P Kardas, P K Keith, M Kerkhof, H A M Kerstjens, N Khaltaev, M Kogevinas, V Kolek, G H Koppelman, M L Kowalski, M Kuitunen, I Kull, V Kvedariene, B Lambrecht, S Lau, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K C Lodrup Carlsen, R Louis, C Lupinek, W MacNee, Y Magar, A Magnan, B Mahboub, D Maier, I Majer, J Malva, P Manning, E De Manuel Keenoy, G D Marshall, M R Masjedi, E Mathieu-Dupas, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O Meltzer, J Mercier, H Merk, N Miculinic, F Mihaltan, B Milenkovic, J Millot-Keurinck, Y Mohammad, I Momas, R Mösges, A Muraro, L Namazova-Baranova, R Nadif, H Neffen, K Nekam, A Nieto, B Niggemann, L Nogueira-Silva, M Nogues, T D Nyembue, K Ohta, Y Okamoto, K Okubo, M Olive-Elias, S Ouedraogo, P Paggiaro, I Pali-Schöll, S Palkonen, P Panzner, A Papi, H S Park, G Passalacqua, S Pedersen, A M Pereira, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, W Pohl, T A Popov, F Portejoie, D Postma, L K Poulsen, D Price, K F Rabe, F Raciborski, G Roberts, C Robalo-Cordeiro, F Rodenas, L Rodriguez-Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, M Rottem, M Sanchez-Borges, J Sastre-Dominguez, G K Scadding, N Scichilone, P Schmid-Grendelmeier, E Serrano, M Shields, V Siroux, J C Sisul, I Skrindo, H A Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J Sterk, T Strandberg, J Sunyer, C Thijs, M Triggiani, R Valenta, A Valero, M van Eerd, E van Ganse, M van Hague, O Vandenplas, L L Varona, B Vellas, G Vezzani, T Vazankari, G Viegi, T Vontetsianos, M Wagenmann, S Walker, D Y Wang, U Wahn, T Werfel, B Whalley, D M Williams, S Williams, N Wilson, J Wright, B P Yawn, P K Yiallouros, O M Yusuf, A Zaidi, H J Zar, M E Zernotti, L Zhang, N Zhong, M Zidarn
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28031785/cross-reactive-ltp-sensitization-in-food-dependent-exercise-induced-urticaria-anaphylaxis-a-pilot-study-of-a-component-resolved-and-in-vitro-depletion-approach
#19
Diana Margarida Gonçalves Solha Pereira da Silva, Teresa Maria Silva Vieira, Ana Maria Alves Pereira, André Miguel Afonso de Sousa Moreira, José Luís Dias Delgado
BACKGROUND: Challenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and an allergen microarray test in the identification of IgE-mediated cross-reactive food allergens in patients with suspected FDEIA or food-dependent exercise-induced urticaria and panallergen sensitization. METHODS: Three patients with a history of food dependent exercise induced urticaria/anaphylaxis and food panallergen sensitization in whom a food-exercise challenge was not feasible were selected: a 25-year-old man with cholinergic urticaria who experienced generalized urticaria and angioedema during a soccer match after drinking a peach-based soft drink; a 19-year-old woman with allergic rhinitis and controlled asthma who experienced anaphylactic shock while playing soccer, having eaten walnuts in the previous 90 min; and a 57-year-old man with baker's asthma who experienced four episodes of anaphylaxis during exercise after ingesting wheat-containing food...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27999658/exploratory-analysis-of-cd63-and-cd203c-expression-in-basophils-from-hazelnut-sensitized-and-allergic-individuals
#20
Bianca Lötzsch, Sabine Dölle, Stefan Vieths, Margitta Worm
BACKGROUND: Sensitization to hazelnut (HN) is frequent and requires clarification to determine whether this sensitization is clinically relevant. The aim of this study was to investigate basophil activation profiles in HN-sensitized and allergic subjects. METHODS: Basophil activation was determined by flow cytometric analyses of CD63 and CD203c expression using several HN allergen concentrations. Depending on their clinical reaction pattern, an oral allergy symptom group (OAS, n = 20), a systemic reaction group (n = 12) and a sensitized group without clinical symptoms (n = 20) were identified...
2016: Clinical and Translational Allergy
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