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Clinical and Translational Allergy

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https://www.readbyqxmd.com/read/28400946/the-state-of-asthma-epidemiology-an-overview-of-systematic-reviews-and-their-quality
#1
Jon Genuneit, Annina M Seibold, Christian J Apfelbacher, George N Konstantinou, Jennifer J Koplin, Stefania La Grutta, Kirsty Logan, Carsten Flohr, Michael R Perkin
BACKGROUND: Recently, we have published an overview of systematic reviews in allergy epidemiology and identified asthma as the most commonly reviewed allergic disease. Building on this work, we aimed to investigate the quality of systematic reviews in asthma using the AMSTAR checklist and to provide a reference for future, more in-depth assessment of the extent of previous knowledge. METHODS: We included all 307 systematic reviews indexed with asthma, including occupational asthma, and/or wheeze from our previous search in PubMed and EMBASE up to December 2014 for systematic reviews on epidemiological research on allergic diseases...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28392912/erratum-to-looking-forward-to-new-targeted-treatments-for-chronic-spontaneous-urticaria
#2
Emek Kocatürk, Marcus Maurer, Martin Metz, Clive Grattan
[This corrects the article DOI: 10.1186/s13601-016-0139-2.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28392911/early-childhood-risk-factors-for-rhinoconjunctivitis-in-adolescence-a-prospective-birth-cohort-study
#3
Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz, Susanne Halken
BACKGROUND: Rhinoconjunctivitis is a global health problem and one of the most common chronic conditions in children. Development of rhinoconjunctivitis depends on both genetic and environmental factors. Many studies have investigated rhinoconjunctivitis, but only few studies have evaluated the risk factors for non-allergic rhinoconjunctivitis in children finding family history of atopic diseases and gender to be of importance. The aim of this study was to investigate possible risk factors in early life for rhinoconjunctivitis, allergic as well as non-allergic, in adolescence...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28321292/low-percentage-of-clinically-relevant-pistachio-nut-and-mango-co-sensitisation-in-cashew-nut-sensitised-children
#4
J P M van der Valk, R El Bouche, R Gerth van Wijk, H de Groot, H J Wichers, A E J Dubois, N W de Jong
BACKGROUND: Cashew nut, pistachio nut and mango belong to the Anacardiaceae family and are botanically related. Therefore, cashew nut sensitised children are frequently advised to eliminate cashew nuts and pistachio nuts from their diet. The 'Improvement of Diagnostic mEthods for ALlergy assessment (IDEAL trial number NTR3572) study showed that cashew nut sensitised children were co-sensitised to pistachio nut in 98% of cases and to mango in 21% of cases. The aim of this follow-up study to IDEAL is to assess the clinical relevance of co-sensitisation to pistachio nut and mango in cashew nut sensitised children...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28293415/approach-to-the-diagnosis-of-drug-hypersensitivity-reactions-similarities-and-differences-between-europe-and-north-america
#5
REVIEW
M J Torres, A Romano, G Celik, P Demoly, D A Khan, E Macy, M Park, K Blumenthal, W Aberer, M Castells, A Barbaud, C Mayorga, P Bonadonna
Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28293414/galectin-3-an-early-predictive-biomarker-of-modulation-of-airway-remodeling-in-patients-with-severe-asthma-treated-with-omalizumab-for-36%C3%A2-months
#6
Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto, Giorgio Walter Canonica
BACKGROUND: Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical and physiologic variables that encompass multiple phenotypes and are treated with nonspecific anti-inflammatory therapies. Based on the modulation of airway remodeling after 12 months of anti-immunoglobulin E (IgE) treatment, we identified two phenotypes (omalizumab responder, OR; and non-omalizumab responder, NOR) and performed morphometric analysis of bronchial biopsy specimens...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28289538/effectiveness-and-safety-of-antihistamines-up-to-fourfold-or-higher-in-treatment-of-chronic-spontaneous-urticaria
#7
Mignon T van den Elzen, Harmieke van Os-Medendorp, Imke van den Brink, Karin van den Hurk, Ouliana I Kouznetsova, Alexander S H J Lokin, Anna-Marijke Laheij-de Boer, Heike Röckmann, Carla A F M Bruijnzeel-Koomen, André C Knulst
BACKGROUND: Treatment with second-generation antihistamines is recommended in patients with chronic spontaneous urticaria (CSU). Some patients remain unresponsive even after up-dosing up to fourfold. Many third line treatment options have limited availability and/or give rise to significant side effects. We investigated effectiveness and safety of antihistamine treatment with dosages up to fourfold and higher. METHODS: This retrospective analysis of patients' records was performed in adult CSU patients suffering wheals and/or angioedema (AE)...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28239450/erratum-to-scaling-up-strategies-of-the-chronic-respiratory-disease-programme-of-the-european-innovation-partnership-on-active-and-healthy-ageing-action-plan-b3-area-5
#8
J Bousquet, J Farrell, G Crooks, P Hellings, E H Bel, M Bewick, N H Chavannes, J Correia de Sousa, A A Cruz, T Haahtela, G Joos, N Khaltaev, J Malva, A Muraro, M Nogues, S Palkonen, S Pedersen, C Robalo-Cordeiro, B Samolinski, T Strandberg, A Valiulis, A Yorgancioglu, T Zuberbier, A Bedbrook, W Aberer, M Adachi, A Agusti, C A Akdis, M Akdis, J Ankri, A Alonso, I Annesi-Maesano, I J Ansotegui, J M Anto, S Arnavielhe, H Arshad, C Bai, I Baiardini, C Bachert, A K Baigenzhin, C Barbara, E D Bateman, B Beghé, A Ben Kheder, K S Bennoor, M Benson, K C Bergmann, T Bieber, C Bindslev-Jensen, L Bjermer, H Blain, F Blasi, A L Boner, M Bonini, S Bonini, S Bosnic-Anticevitch, L P Boulet, R Bourret, P J Bousquet, F Braido, A H Briggs, C E Brightling, J Brozek, R Buhl, P G Burney, A Bush, F Caballero-Fonseca, D Caimmi, M A Calderon, P M Calverley, P A M Camargos, G W Canonica, T Camuzat, K H Carlsen, W Carr, A Carriazo, T Casale, A M Cepeda Sarabia, L Chatzi, Y Z Chen, R Chiron, E Chkhartishvili, A G Chuchalin, K F Chung, G Ciprandi, I Cirule, L Cox, D J Costa, A Custovic, R Dahl, S E Dahlen, U Darsow, G De Carlo, F De Blay, T Dedeu, D Deleanu, E De Manuel Keenoy, P Demoly, J A Denburg, P Devillier, A Didier, A T Dinh-Xuan, R Djukanovic, D Dokic, H Douagui, G Dray, R Dubakiene, S R Durham, M S Dykewicz, Y El-Gamal, R Emuzyte, L M Fabbri, M Fletcher, A Fiocchi, A Fink Wagner, J Fonseca, W J Fokkens, F Forastiere, P Frith, M Gaga, A Gamkrelidze, J Garces, J Garcia-Aymerich, B Gemicioğlu, J E Gereda, S González Diaz, M Gotua, I Grisle, L Grouse, Z Gutter, M A Guzmán, L G Heaney, B Hellquist-Dahl, D Henderson, A Hendry, J Heinrich, D Heve, F Horak, J O' B Hourihane, P Howarth, M Humbert, M E Hyland, M Illario, J C Ivancevich, J R Jardim, E J Jares, C Jeandel, C Jenkins, S L Johnston, O Jonquet, K Julge, K S Jung, J Just, I Kaidashev, M R Khaitov, O Kalayci, A F Kalyoncu, T Keil, P K Keith, L Klimek, B Koffi N'Goran, V Kolek, G H Koppelman, M L Kowalski, I Kull, P Kuna, V Kvedariene, B Lambrecht, S Lau, D Larenas-Linnemann, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K Lodrup Carlsen, R Louis, W MacNee, Y Magard, A Magnan, B Mahboub, A Mair, I Majer, M J Makela, P Manning, S Mara, G D Marshall, M R Masjedi, P Matignon, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O Meltzer, A Menzies-Gow, H Merk, J P Michel, N Miculinic, F Mihaltan, B Milenkovic, G M Y Mohammad, M Molimard, I Momas, A Montilla-Santana, M Morais-Almeida, M Morgan, R Mösges, J Mullol, S Nafti, L Namazova-Baranova, R Naclerio, A Neou, H Neffen, K Nekam, B Niggemann, G Ninot, T D Nyembue, R E O'Hehir, K Ohta, Y Okamoto, K Okubo, S Ouedraogo, P Paggiaro, I Pali-Schöll, P Panzner, N Papadopoulos, A Papi, H S Park, G Passalacqua, I Pavord, R Pawankar, R Pengelly, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, D Poethig, W Pohl, T A Popov, F Portejoie, P Potter, D Postma, D Price, K F Rabe, F Raciborski, F Radier Pontal, S Repka-Ramirez, S Reitamo, S Rennard, F Rodenas, J Roberts, J Roca, L Rodriguez Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, L Rosenwasser, M Rottem, D Ryan, M Sanchez-Borges, G K Scadding, H J Schunemann, E Serrano, P Schmid-Grendelmeier, H Schulz, A Sheikh, M Shields, N Siafakas, Y Sibille, T Similowski, F E R Simons, J C Sisul, I Skrindo, H A Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J Sterk, J Sunyer, C Thijs, T To, A Todo-Bom, M Triggiani, R Valenta, A L Valero, E Valia, E Valovirta, E Van Ganse, M van Hage, O Vandenplas, T Vasankari, B Vellas, J Vestbo, G Vezzani, P Vichyanond, G Viegi, C Vogelmeier, T Vontetsianos, M Wagenmann, B Wallaert, S Walker, D Y Wang, U Wahn, M Wickman, D M Williams, S Williams, J Wright, B P Yawn, P K Yiallouros, O M Yusuf, A Zaidi, H J Zar, M E Zernotti, L Zhang, N Zhong, M Zidarn, J Mercier
[This corrects the article DOI: 10.1186/s13601-016-0116-9.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28149501/is-fruit-and-vegetable-intake-associated-with-asthma-or-chronic-rhino-sinusitis-in-european-adults-results-from-the-global-allergy-and-asthma-network-of-excellence-ga-2-len-survey
#9
Vanessa Garcia-Larsen, Rhonda Arthur, James F Potts, Peter H Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, Ana Todo Bom, Grzegorz Brożek, Joanna Makowska, Marek L Kowalski, Trine Thilsing, Thomas Keil, Paolo M Matricardi, Kjell Torén, Thibaut van Zele, Claus Bachert, Barbara Rymarczyk, Christer Janson, Bertil Forsberg, Ewa Niżankowska-Mogilnicka, Peter G J Burney
BACKGROUND: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. OBJECTIVE: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. METHODS: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA(2)LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28078080/three-cases-of-anaphylaxis-following-injection-of-a-depot-corticosteroid-with-evidence-of-ige-sensitization-to-macrogols-rather-than-the-active-steroid
#10
Nicolaj Brandt, Lene H Garvey, Ulla Bindslev-Jensen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz
We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28078079/looking-forward-to-new-targeted-treatments-for-chronic-spontaneous-urticaria
#11
REVIEW
Emek Kocatürk, Marcus Maurer, Martin Metz, Clive Grattan
The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease. But there is still a hard core of patients who do not tolerate or benefit from existing therapies and who require effective treatment. Novel approaches include the use of currently available drugs off-licence, investigational drugs currently undergoing clinical trials and exploring the potential for therapies directed at pathophysiological targets in CSU...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28050247/aria-2016-care-pathways-implementing-emerging-technologies-for-predictive-medicine-in-rhinitis-and-asthma-across-the-life-cycle
#12
REVIEW
J Bousquet, P W Hellings, I Agache, A Bedbrook, C Bachert, K C Bergmann, M Bewick, C Bindslev-Jensen, S Bosnic-Anticevitch, C Bucca, D P Caimmi, P A M Camargos, G W Canonica, T Casale, N H Chavannes, A A Cruz, G De Carlo, R Dahl, P Demoly, P Devillier, J Fonseca, W J Fokkens, N A Guldemond, T Haahtela, M Illario, J Just, T Keil, L Klimek, P Kuna, D Larenas-Linnemann, M Morais-Almeida, J Mullol, R Murray, R Naclerio, R E O'Hehir, N G Papadopoulos, R Pawankar, P Potter, D Ryan, B Samolinski, H J Schunemann, A Sheikh, F E R Simons, C Stellato, A Todo-Bom, P V Tomazic, A Valiulis, E Valovirta, M T Ventura, M Wickman, I Young, A Yorgancioglu, T Zuberbier, W Aberer, C A Akdis, M Akdis, I Annesi-Maesano, J Ankri, I J Ansotegui, J M Anto, S Arnavielhe, A Asarnoj, H Arshad, F Avolio, I Baiardini, C Barbara, M Barbagallo, E D Bateman, B Beghé, E H Bel, K S Bennoor, M Benson, A Z Białoszewski, T Bieber, L Bjermer, H Blain, F Blasi, A L Boner, M Bonini, S Bonini, I Bosse, J Bouchard, L P Boulet, R Bourret, P J Bousquet, F Braido, A H Briggs, C E Brightling, J Brozek, R Buhl, C Bunu, E Burte, A Bush, F Caballero-Fonseca, M A Calderon, T Camuzat, V Cardona, P Carreiro-Martins, A M Carriazo, K H Carlsen, W Carr, A M Cepeda Sarabia, M Cesari, L Chatzi, R Chiron, T Chivato, E Chkhartishvili, A G Chuchalin, K F Chung, G Ciprandi, J Correia de Sousa, L Cox, G Crooks, A Custovic, S E Dahlen, U Darsow, T Dedeu, D Deleanu, J A Denburg, G De Vries, A Didier, A T Dinh-Xuan, D Dokic, H Douagui, G Dray, R Dubakiene, S R Durham, G Du Toit, M S Dykewicz, P Eklund, Y El-Gamal, E Ellers, R Emuzyte, J Farrell, A Fink Wagner, A Fiocchi, M Fletcher, F Forastiere, M Gaga, A Gamkrelidze, B Gemicioğlu, J E Gereda, R Gerth van Wick, S González Diaz, I Grisle, L Grouse, Z Gutter, M A Guzmán, B Hellquist-Dahl, J Heinrich, F Horak, J O' B Hourihane, M Humbert, M Hyland, G Iaccarino, E J Jares, C Jeandel, S L Johnston, G Joos, O Jonquet, K S Jung, M Jutel, I Kaidashev, M Khaitov, O Kalayci, A F Kalyoncu, P Kardas, P K Keith, M Kerkhof, H A M Kerstjens, N Khaltaev, M Kogevinas, V Kolek, G H Koppelman, M L Kowalski, M Kuitunen, I Kull, V Kvedariene, B Lambrecht, S Lau, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K C Lodrup Carlsen, R Louis, C Lupinek, W MacNee, Y Magar, A Magnan, B Mahboub, D Maier, I Majer, J Malva, P Manning, E De Manuel Keenoy, G D Marshall, M R Masjedi, E Mathieu-Dupas, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O Meltzer, J Mercier, H Merk, N Miculinic, F Mihaltan, B Milenkovic, J Millot-Keurinck, Y Mohammad, I Momas, R Mösges, A Muraro, L Namazova-Baranova, R Nadif, H Neffen, K Nekam, A Nieto, B Niggemann, L Nogueira-Silva, M Nogues, T D Nyembue, K Ohta, Y Okamoto, K Okubo, M Olive-Elias, S Ouedraogo, P Paggiaro, I Pali-Schöll, S Palkonen, P Panzner, A Papi, H S Park, G Passalacqua, S Pedersen, A M Pereira, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, W Pohl, T A Popov, F Portejoie, D Postma, L K Poulsen, D Price, K F Rabe, F Raciborski, G Roberts, C Robalo-Cordeiro, F Rodenas, L Rodriguez-Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, M Rottem, M Sanchez-Borges, J Sastre-Dominguez, G K Scadding, N Scichilone, P Schmid-Grendelmeier, E Serrano, M Shields, V Siroux, J C Sisul, I Skrindo, H A Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J Sterk, T Strandberg, J Sunyer, C Thijs, M Triggiani, R Valenta, A Valero, M van Eerd, E van Ganse, M van Hague, O Vandenplas, L L Varona, B Vellas, G Vezzani, T Vazankari, G Viegi, T Vontetsianos, M Wagenmann, S Walker, D Y Wang, U Wahn, T Werfel, B Whalley, D M Williams, S Williams, N Wilson, J Wright, B P Yawn, P K Yiallouros, O M Yusuf, A Zaidi, H J Zar, M E Zernotti, L Zhang, N Zhong, M Zidarn
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28031785/cross-reactive-ltp-sensitization-in-food-dependent-exercise-induced-urticaria-anaphylaxis-a-pilot-study-of-a-component-resolved-and-in-vitro-depletion-approach
#13
Diana Margarida Gonçalves Solha Pereira da Silva, Teresa Maria Silva Vieira, Ana Maria Alves Pereira, André Miguel Afonso de Sousa Moreira, José Luís Dias Delgado
BACKGROUND: Challenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and an allergen microarray test in the identification of IgE-mediated cross-reactive food allergens in patients with suspected FDEIA or food-dependent exercise-induced urticaria and panallergen sensitization. METHODS: Three patients with a history of food dependent exercise induced urticaria/anaphylaxis and food panallergen sensitization in whom a food-exercise challenge was not feasible were selected: a 25-year-old man with cholinergic urticaria who experienced generalized urticaria and angioedema during a soccer match after drinking a peach-based soft drink; a 19-year-old woman with allergic rhinitis and controlled asthma who experienced anaphylactic shock while playing soccer, having eaten walnuts in the previous 90 min; and a 57-year-old man with baker's asthma who experienced four episodes of anaphylaxis during exercise after ingesting wheat-containing food...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27999658/exploratory-analysis-of-cd63-and-cd203c-expression-in-basophils-from-hazelnut-sensitized-and-allergic-individuals
#14
Bianca Lötzsch, Sabine Dölle, Stefan Vieths, Margitta Worm
BACKGROUND: Sensitization to hazelnut (HN) is frequent and requires clarification to determine whether this sensitization is clinically relevant. The aim of this study was to investigate basophil activation profiles in HN-sensitized and allergic subjects. METHODS: Basophil activation was determined by flow cytometric analyses of CD63 and CD203c expression using several HN allergen concentrations. Depending on their clinical reaction pattern, an oral allergy symptom group (OAS, n = 20), a systemic reaction group (n = 12) and a sensitized group without clinical symptoms (n = 20) were identified...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27980722/immunoglobulin-free-light-chains-in-adult-atopic-dermatitis-patients-do-not-correlate-with-disease-severity
#15
J L Thijs, K Knipping, C A F Bruijnzeel-Koomen, J Garssen, M S de Bruin-Weller, D J Hijnen
BACKGROUND: Although total IgE levels have been proposed as a biomarker for disease severity in atopic dermatitis (AD) and are increased in the majority of AD patients, they do not correlate with disease severity during short-term follow-up. During the synthesis of immunoglobulins, free light chains (Ig-FLCs) are produced in excess over heavy chains. In comparison with IgE molecules, Ig-FLCs have a very short serum half-life. Therefore, Ig-FLCs might be more suitable as a biomarker for disease severity during follow-up...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27957322/a-mutually-beneficial-collaboration-between-the-european-academy-of-allergy-and-clinical-immunology-junior-members-and-clinical-and-translational-allergy
#16
EDITORIAL
Peter Valentin Tomazic, Anke Graessel, Diana Silva, Ibon Eguiluz-Gracia, George V Guibas, Clive Grattan, Jean Bousquet, Olympia Tsilochristou
The European Academy of Allergy and Clinical Immunology (EAACI) Junior Members (JM) comprise the largest EAACI section with around 4000 clinicians and scientists under 35 years of age working in the field of allergy and clinical immunology. The Junior Member collaboration with Clinical and Translational Allergy Journal is a mutually beneficial relationship providing Junior Members of EAACI with excellent opportunities to publish their work in the Journal, enhance their visibility in their respective field, and get involved with Journal-related activities and processes...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27895895/allergy-immunotherapy-across-the-life-cycle-to-promote-active-and-healthy-ageing-from-research-to-policies-an-airways-integrated-care-pathways-icps-programme-item-action-plan-b3-of-the-european-innovation-partnership-on-active-and-healthy-ageing-and-the-global
#17
REVIEW
M A Calderon, P Demoly, T Casale, C A Akdis, C Bachert, M Bewick, B M Bilò, B Bohle, S Bonini, A Bush, D P Caimmi, G W Canonica, V Cardona, A M Chiriac, L Cox, A Custovic, F De Blay, P Devillier, A Didier, G Di Lorenzo, G Du Toit, S R Durham, P Eng, A Fiocchi, A T Fox, R Gerth van Wijk, R M Gomez, T Haathela, S Halken, P W Hellings, L Jacobsen, J Just, L K Tanno, J Kleine-Tebbe, L Klimek, E F Knol, P Kuna, D E Larenas-Linnemann, A Linneberg, M Matricardi, H J Malling, R Moesges, J Mullol, A Muraro, N Papadopoulos, G Passalacqua, E Pastorello, O Pfaar, D Price, P Rodriguez Del Rio, R Ruëff, B Samolinski, G K Scadding, G Senti, M H Shamji, A Sheikh, J C Sisul, D Sole, G J Sturm, A Tabar, R Van Ree, M T Ventura, C Vidal, E M Varga, M Worm, T Zuberbier, J Bousquet
Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27891215/hypothesis-may-e-cigarette-smoking-boost-the-allergic-epidemic
#18
EDITORIAL
Jean Bousquet, Claus Bachert, Laura Crotty Alexander, Frank T Leone
No abstract text is available yet for this article.
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27826414/standardization-of-double-blind-placebo-controlled-food-challenge-with-soy-within-a-multicentre-trial
#19
R Treudler, A Franke, A Schmiedeknecht, B K Ballmer-Weber, M Worm, T Werfel, U Jappe, T Biedermann, J Schmitt, R Brehler, A Kleinheinz, J Kleine-Tebbe, H Brüning, F Ruëff, J Ring, J Saloga, K Schäkel, T Holzhauser, St Vieths, J C Simon
BACKGROUND: Multicentre trials investigating food allergies by double blind placebo controlled food challenges (DBPCFC) need standardized procedures, challenge meals and evaluation criteria. We aimed at developing a standardized approach for identifying patients with birch related soy allergy by means of DBPCFC to soy, including determination of threshold levels, in a multicentre setting. METHODS: Microbiologically stable soy challenge meals were composed of protein isolate with consistent Gly m 4 levels...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27733903/impaired-health-related-quality-of-life-in-adolescents-with-allergy-to-staple-foods
#20
Jennifer Lisa Penner Protudjer, Sven-Arne Jansson, Roelinde Middelveld, Eva Östblom, Sven-Erik Dahlén, Marianne Heibert Arnlind, Ulf Bengtsson, Ingrid Kallström-Bengtsson, Birgitta Marklund, Georgios Rentzos, Ann-Charlotte Sundqvist, Johanna Åkerström, Staffan Ahlstedt
BACKGROUND: Cow's milk, hen's egg and wheat are staple foods in a typical western diet. Despite the ubiquity of these foods, the impact of staple food allergy on health-related quality of life (HRQL) amongst adolescents is incompletely understood. The aims of this study were to make use of the Swedish version of EuroPrevall's disease-specific food allergy quality of life questionnaire-teenager form (FAQLQ-TF) and to investigate the association between objectively-diagnosed staple food allergy and HRQL amongst adolescents...
2016: Clinical and Translational Allergy
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