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Pathobiology of Aging & Age related Diseases

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https://www.readbyqxmd.com/read/30370017/continuous-overexpression-of-thioredoxin-1-enhances-cancer-development-and-does-not-extend-maximum-lifespan-in-male-c57bl-6-mice
#1
Lisa C Flores, Madeline G Roman, Geneva M Cunningham, Christie Cheng, Sara Dube, Colton Allen, Holly Van Remmen, Gene B Hubbard, Thomas L Saunders, Yuji Ikeno
We examined the effects of continuous overexpression of thioredoxin (Trx) 1 on aging in Trx1 transgenic mice [Tg( TXN )+/0 ]. This study was conducted to test whether increased thioredoxin expression over the lifespan in mice would alter aging and age-related pathology because our previous study demonstrated that Tg(act- TXN )+/0 mice had no significant maximum life extension, possibly due to the use of actin as a promoter, which may have resulted in loss of Trx1 overexpression during aging. To test this hypothesis, we generated new Trx1 transgenic mice using a fragment of the human genome containing the TXN gene with an endogenous promoter to ensure continuous overexpression of Trx1 throughout the lifespan...
2018: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/30319737/modeling-alzheimer-s-disease-in-progeria-mice-an-age-related-concept
#2
Kavita Sharma, Martin Darvas, C Dirk Keene, Laura J Niedernhofer, Warren Ladiges
The prevalence of Alzheimer's disease (AD) is expected to dramatically increase in older people worldwide. Efforts to find disease-modifying treatments have been largely unsuccessful because of the focus on disease-specific pathogenesis, and lack of animal models to study AD in the context of aging and age-related co-morbidities. The geroscience approach to studying AD would suggest that modulation of aging per se would be a useful strategy, but a mammalian model system that combines both aging and AD is not available...
2018: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/30220987/evaluation-of-aging-diabetes-mellitus-and-skin-wounds-by-scanning-acoustic-microscopy-with-protease-digestion
#3
Katsutoshi Miura, Kanna Yamashita
Scanning acoustic microscopy (SAM) can assess tissue stiffness by calculating the speed of sound (SOS) through tissues. SOS increases as tissue stiffness increases. Sensitivity to protease digestion depends on protein type, concentration, and modification. We analyzed the SOS images of formalin-fixed paraffin-embedded skin sections from elderly, young, diabetic, and nondiabetic subjects, as well as chronic and acute wounds. SAM provided high-resolution histology similar to LM and revealed characteristic SOS alteration following pepsin treatment...
2018: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29321828/exendin-4-protects-mice-from-d-galactose-induced-hepatic-and-pancreatic-dysfunction
#4
Akram Ahangarpour, Ali Akbar Oroojan, Mohammad Badavi
Investigations into pharmaceutical intervention of pancreatic and hepatic dysfunction associated with metabolic disturbances have received relatively little attention. The aim of this study was to investigate the protective effects of exendin-4 in mice receiving D-galactose, a reducing sugar that triggers ROS production and inflammatory mediators affecting the pancreas and liver. Exendin-4 is an United States Food and Drug Administration (FDA) approved glucagon-like peptide that increases insulin dependent glycogen synthesis and glucose uptake...
2018: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29291036/testing-drug-combinations-to-slow-aging
#5
EDITORIAL
Warren Ladiges, Denny Liggitt
No abstract text is available yet for this article.
2018: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29291035/the-potential-use-of-physical-resilience-to-predict-healthy-aging
#6
REVIEW
Anna Schorr, Christy Carter, Warren Ladiges
Physical resilience is the ability of an organism to respond to stressors that acutely disrupt normal physiological homeostasis. By definition, resilience decreases with increasing age, while frailty, defined as a decline in tissue function, increases with increasing age. Assessment of resilience could therefore be an informative early paradigm to predict healthy aging compared to frailty, which measures late life dysfunction. Parameters for resilience in the laboratory mouse are not yet well defined, and no single standardized stress test exists...
2018: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29152163/effect-of-aging-and-lifestyle-on-photoreceptors-and-retinal-pigment-epithelium-cross-sectional-study-in-a-healthy-danish-population
#7
Jacob Harris, Yousif Subhi, Torben L Sørensen
Photoreceptors and their supporting retinal pigment epithelium constitute the key functional parts of the retina. Here, a study was undertaken to show how aging and lifestyle factors affect the photoreceptor layer and the retinal pigment epithelium and Bruch's membrane complex (RPE-BM) in vivo in a healthy Danish population using spectral-domain optical coherence tomography. This was a cross-sectional study of healthy humans aged ≥50 years. All participants were interviewed for medical history and lifestyle factors...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/28515862/guidelines-for-collection-and-processing-of-lungs-from-aged-mice-for-histological-studies
#8
John Morton, Timothy A Snider
Pulmonary inflammation and the development of spontaneous lung tumors are important age-related lesions in mice. Therefore, gross and histological examination of the respiratory system is a critical component of geropathology research studies for translating surrogate endpoints to clinical aging studies. Collection, trimming, and processing of lung tissue from aged mice require a high-quality sequential process since aged mice are irreplaceable resource-intensive animal models. This protocol provides a basic technique that provides excellent sections for histological evaluation of the respiratory system of old mice suitable for most research applications...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/28515861/the-emerging-role-of-geropathology-in-preclinical-aging-studies
#9
EDITORIAL
Warren Ladiges
No abstract text is available yet for this article.
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/28515860/cardiotoxicity-occurred-in-aged-c57bl-6nia-mice-given-a-formulation-containing-poloxamer-407-hydrogel
#10
Terri Iwata, John Morton, Jessica Snyder, Xuan Ge
No abstract text is available yet for this article.
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/28326165/neurochemical-and-motor-changes-in-mice-with-combined-mutations-linked-to-parkinson-s-disease
#11
Xiang Bai, Margaret Chia-Ying Wey, Paul Anthony Martinez, Chao Shi, Elizabeth Fernandez, Randy Strong
Considerable evidence suggests that oxidative stress plays a role in the pathogenesis of Parkinson's disease (PD), the most prevalent neurodegenerative movement disorder. Reduced expression of aldehyde dehydrogenase-1 (ALDH1) and glutathione peroxidase-1 (GPX1), enzymes that function to detoxify aldehydes and hydroxyl radicals, respectively, has been reported in the substantia nigra of patients who died with PD. To determine whether deficiency in these two genes contributes to the pathogenesis of PD, mice were generated with homozygous null mutations of both Aldh1a1 (the murine homolog of ALDH1) and Gpx1 genes [knockout (KO) mice]...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27924738/promoting-healthy-aging-intervening-with-diet-drugs-or-exercise
#12
(no author information available yet)
No abstract text is available yet for this article.
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27876455/multiple-morbidities-in-companion-dogs-a-novel-model-for-investigating-age-related-disease
#13
Kelly Jin, Jessica M Hoffman, Kate E Creevy, Dan G O'Neill, Daniel E L Promislow
The proportion of men and women surviving over 65 years has been steadily increasing over the last century. In their later years, many of these individuals are afflicted with multiple chronic conditions, placing increasing pressure on healthcare systems. The accumulation of multiple health problems with advanced age is well documented, yet the causes are poorly understood. Animal models have long been employed in attempts to elucidate these complex mechanisms with limited success. Recently, the domestic dog has been proposed as a promising model of human aging for several reasons...
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27782874/corrigendum
#14
(no author information available yet)
[This corrects the article DOI: 10.3402/pba.v6.32981.].
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27733235/cardiovascular-katp-channels-and-advanced-aging
#15
REVIEW
Hua-Qian Yang, Ekaterina Subbotina, Ravichandran Ramasamy, William A Coetzee
With advanced aging, there is a decline in innate cardiovascular function. This decline is not general in nature. Instead, specific changes occur that impact the basic cardiovascular function, which include alterations in biochemical pathways and ion channel function. This review focuses on a particular ion channel that couple the latter two processes, namely the KATP channel, which opening is promoted by alterations in intracellular energy metabolism. We show that the intrinsic properties of the KATP channel changes with advanced aging and argue that the channel can be further modulated by biochemical changes...
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27613499/grip-strength-is-potentially-an-early-indicator-of-age-related-decline-in-mice
#16
Xuan Ge, Anthony Cho, Marcia A Ciol, Christina Pettan-Brewer, Jessica Snyder, Peter Rabinovitch, Warren Ladiges
The hand grip test has been correlated with mobility and physical performance in older people and has been shown to be a long-term predictor of mortality. Implementation of new strategies for enhancing healthy aging and maintaining independent living are dependent on predictable preclinical studies. The mouse is used extensively as a model in these types of studies, and the paw grip strength test is similar to the hand grip test for people in that it assesses the ability to grip a device with the paw, is non-invasive and easy to perform, and provides reproducible information...
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27558317/fatty-old-hearts-role-of-cardiac-lipotoxicity-in-age-related-cardiomyopathy
#17
REVIEW
Konstantinos Drosatos
Age-related cardiomyopathy accounts for a significant part of heart failure cases. Imbalance of the energetic equilibrium of the heart along with mitochondrial dysfunction and impaired β-adrenergic receptor signaling contributes in the aggravation of cardiac function in the elderly. In this review article, studies that correlate cardiac aging with lipotoxicity are summarized. The involvement of inhibition of peroxisome proliferator-activated receptor-α, β-adrenergic receptor desensitization, and mitochondrial dysfunction as underlying mechanisms for the lipid-driven age-related cardiomyopathy are presented with the aim to indicate potential therapeutic targets for cardiac aging...
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27452489/moving-toward-common-use-of-the-marmoset-as-a-non-human-primate-aging-model
#18
EDITORIAL
Adam B Salmon
No abstract text is available yet for this article.
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27341957/pharmaceutical-inhibition-of-mtor-in-the-common-marmoset-effect-of-rapamycin-on-regulators-of-proteostasis-in-a-non-human-primate
#19
Matthew Lelegren, Yuhong Liu, Corinna Ross, Suzette Tardif, Adam B Salmon
BACKGROUND: Inhibition of mechanistic target of rapamycin (mTOR) has emerged as a viable means to lengthen lifespan and healthspan in mice, although it is still unclear whether these benefits will extend to other mammalian species. We previously reported results from a pilot experiment wherein common marmosets (Callithrix jacchus) were treated orally with rapamycin to reduce mTOR signaling in vivo in line with previous reports in mice and humans. Further, long-term treatment did not significantly alter body weight, daily activity, blood lipid concentrations, or glucose metabolism in this cohort...
2016: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/27317189/neuropathological-assessment-and-validation-of-mouse-models-for-alzheimer-s-disease-applying-nia-aa-guidelines
#20
EDITORIAL
C Dirk Keene, Martin Darvas, Brian Kraemer, Denny Liggitt, Christina Sigurdson, Warren Ladiges
Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD), have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy of drugs for treating AD patients. Therefore, development of more translationally relevant AD mouse models remains a critical unmet need in the field. A concept not previously implemented in AD preclinical drug testing is the use of mouse lines that have been validated for neuropathological features of human AD...
2016: Pathobiology of Aging & Age related Diseases
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