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Journal of Clinical and Experimental Hepatology

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https://www.readbyqxmd.com/read/28003728/looking-beyond-sorafenib-to-treat-advanced-hepatocellular-carcinoma
#1
Swastik Agrawal
No abstract text is available yet for this article.
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003727/an-unusual-complication-of-pyogenic-liver-abscess
#2
Hemanta K Nayak, Kamlesh Kumar, Vivek A Saraswat, Gaurav Pandey, Samir Mohindra, Ankur Singh
No abstract text is available yet for this article.
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003726/enucleation-sign-a-computed-tomographic-appearance-of-ruptured-hepatocellular-carcinoma
#3
Manphool Singhal, Upasna Sinha, Naveen Kalra, Ajay Duseja, Niranjan Khandelwal
Rupture of hepatocellular carcinoma (HCC) is a catastrophic complication, which carries high mortality. We report a case of spontaneous rupture of HCC, diagnosis of which was considered on clinical presentation and confirmed on computed tomographic (CT) scan. On CT scan, characteristic 'enucleation sign' was observed on arterial phase imaging, where a hypervascular peripheral mass showing central necrosis was seen protruding from liver surface with discontinuity of hepatic parenchyma associated with high attenuation ascites...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003725/neonatal-cholestasis-as-initial-presentation-of-portosystemic-shunt-a-case-report
#4
Güzide Doğan, Fatih Düzgün, Serdar Tarhan, Yeliz Çağan Appak, Erhun Kasırga
Congenital intrahepatic portosystemic shunts are rare in children. Portosystemic venous malformations are characterized by extreme clinical variability. We report a full-term 33-day-old male infant presenting with neonatal jaundice. On physical examination, he had generalized icterus and the liver was palpable 3.5 cm below the right costal margin. He had no other symptoms. Laboratory tests showed AST 632 U/L, ALT 198 U/L, total bilirubin 12.1 mg/dL, conjugated bilirubin 10.2 mg/dL, alkaline phosphatase 753 U/L, GGT 47 U/L and glucose 67 U/L...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003724/balloon-occluded-retrograde-transvenous-obliteration-brto-a-novel-method-of-control-of-bleeding-from-post-glue-ulcer-over-gastric-varices-report-of-two-cases-and-review-of-literature
#5
Ritesh Prajapati, Piyush Ranjan, Arun Gupta, Ajit K Yadav
Bleeding gastric varices (GV) are managed by cyanoacrylate glue injection with transjugular intrahepatic portosystemic shunt (TIPSS) as modality for treatment failure. Ulcer can form at the site of glue injection over GV and it can cause bleeding. Treatment approach for such bleed is not well described. Balloon-occluded retrograde transvenous obliteration (BRTO), TIPSS, and devascularization remain the treatment options in this scenario. BRTO is an endovascular procedure where a balloon catheter is inserted into a draining vein of GV, and the sclerosant can be injected into the varices through the catheter during balloon occlusion...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003723/multifocal-intrahepatic-artery-aneurysm-with-fdg-avid-thrombosis-simulating-metastasis-report-of-a-rare-case
#6
Xiaofei Zhang, Ashley E Stueck, Sander Florman, Swan N Thung, Sara Lewis
Hepatic artery aneurysm (HAA), although rare, represents a serious diagnostic and therapeutic challenge due to high rupture rate and associated mortality. Early detection and accurate diagnosis are essential for successful management. Here, we present an extremely rare case of multi-focal intrahepatic HAA with confined intrahepatic rupture and hypermetabolic activity at PET imaging, simulating metastasis of melanoma. A retrospective review found only two other HAA at our institution between 2000 and 2015, both of which involved the extrahepatic artery...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003722/hepatocellular-carcinoma-presenting-as-dyspnea-at-rest-due-to-innumerable-lung-metastasis
#7
Naveen Kumar, Narendra Singh Choudhary, Neeraj Saraf, Sanjiv Saigal
Hepatocellular carcinoma (HCC) the most common primary tumor of the liver usually develops in the setting of chronic liver disease. The presentation is usually due to worsening of chronic liver disease or being detected incidentally on imaging. Rarely metastasis to distant organ becomes the presentation. The authors describe a case of a 70-year-old woman who presented with dyspnea of 2 weeks duration. She was diagnosed as having HCC and extensive multiple pulmonary metastases. She was symptomatic only for the pulmonary metastasis with only 2 lesions in the liver...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003721/primary-biliary-cholangitis-disease-pathogenesis-and-implications-for-established-and-novel-therapeutics
#8
REVIEW
Amitkumar Patel, Anil Seetharam
Primary Biliary Cholangitis is a progressive, autoimmune cholestatic liver disorder. Cholestasis with disease progression may lead to dyslipidemia, osteodystrophy and fat-soluble vitamin deficiency. Portal hypertension may develop prior to advanced stages of fibrosis. Untreated disease may lead to cirrhosis, hepatocellular cancer and need for orthotopic liver transplantation. Classically, diagnosis is made with elevation of alkaline phosphatase, demonstration of circulating antimitochondrial antibody, and if performed: asymmetric destruction/nonsupperative cholangitis of intralobular bile ducts on biopsy...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003720/role-of-diffusion-weighted-imaging-dwi-for-hepatocellular-carcinoma-hcc-detection-and-its-grading-on-3t-mri-a-prospective-study
#9
Shiva Shankar, Naveen Kalra, Anmol Bhatia, Radhika Srinivasan, Paramjeet Singh, Radha K Dhiman, Niranjan Khandelwal, Yogesh Chawla
BACKGROUND: Limited studies have evaluated the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) for histologically grading the hepatocellular carcinoma (HCC). OBJECTIVE: To compare the efficacy of DWI with dynamic contrast enhanced magnetic resonance (DCEMR) in detection of HCC in cirrhosis, and to evaluate whether DWI can be used instead of DCEMR. METHODS: 20 patients of either sex with cirrhosis and suspected of having HCC on screening USG were included in this prospective study approved by the Institutional Ethics Committee...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003719/cirrhotic-patients-have-worse-bowel-preparation-at-screening-colonoscopy-than-chronic-liver-disease-patients-without-cirrhosis
#10
Anika K Anam, Kunal Karia, Arun B Jesudian, Brian P Bosworth
BACKGROUND: Cirrhosis has been shown in small studies to be a predictor of suboptimal bowel preparation at screening colonoscopy. It has yet to be established whether patients with chronic liver disease in the absence of cirrhosis experience equally poor colon cleansing. Intestinal dysmotility related to cirrhosis might impair bowel preparation in this population more than those with chronic liver disease without cirrhosis. OBJECTIVE: This study compared the quality of bowel preparation in cirrhotic and non-cirrhotic patients with chronic liver disease and determined whether this influenced polyp detection rate...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003718/histological-evaluation-of-non-alcoholic-fatty-liver-disease-and-its-correlation-with-different-noninvasive-scoring-systems-with-special-reference-to-fibrosis-a-single-center-experience
#11
Mitali M Rath, Manas K Panigrahi, Kaumudee Pattnaik, Pallavi Bhuyan, Sanjib K Kar, Bijay Misra, Debasis Misra, Chudamani Meher, Omprakash Agrawal, Jayshree Rath, Shivaram P Singh
BACKGROUND: Although liver biopsy remains the gold standard for the diagnosis of non-alcoholic fatty liver disease [NAFLD], many non-invasive markers of liver fibrosis have recently been proposed and assessed as surrogates of liver biopsy. AIMS AND OBJECTIVE: To evaluate the degree of liver fibrosis by different non-invasive fibrosis scoring systems and to compare each non-invasive fibrosis scoring system with histological fibrosis stage. MATERIALS AND METHODS: The study population consists of consecutive patients with biopsy proven NAFLD...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003717/noninvasive-assessment-of-liver-fibrosis-by-transient-elastography-and-fib4-apri-for-prediction-of-treatment-response-in-chronic-hepatitis-c-an-experience-from-a-tertiary-care-hospital
#12
Sunil Taneja, Sunil Tohra, Ajay Duseja, Radha Krishan Dhiman, Yogesh Kumar Chawla
BACKGROUND: Liver fibrosis and its sequel cirrhosis represent a major health care burden, and assessment of fibrosis by biopsy is gradually being replaced by noninvasive methods. In clinical practice, the determination of fibrosis stage is important, since patients with advanced fibrosis have faster progression to cirrhosis and antiviral therapy is indicated in these patients. AIMS: To assess the role of transient elastography (TE) and compare it with APRI and FIB4 for predicting liver fibrosis and assessing the effect of host and viral factors on fibrosis and treatment outcome in CHC patients...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003716/pharmacologic-treatment-of-alcoholic-hepatitis-examining-outcomes-based-on-disease-severity-stratification
#13
Ryan E Owens, Heather S Snyder, Jennifer D Twilla, Sanjaya K Satapathy
OBJECTIVES: Maddrey discriminant function (MDF) score is a measure of disease prognosis in alcoholic hepatitis (AH) used to identify patients at highest risk of mortality and determine the need for initiation of pharmacologic treatment. The purpose of this study was to evaluate the effects of pharmacologic therapy for hospitalized AH patients as stratified by MDF score. METHODS: A retrospective review of patients with an AH diagnosis admitted to a Methodist LeBonheur Healthcare adult hospital between 06/2009 and 06/2014 was conducted...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28003715/high-fructose-intake-impairs-the-hepatic-hypolipidemic-effects-of-a-high-fat-fish-oil-diet-in-c57bl-6-mice
#14
Joshua S Wooten, Tayler N Nick, Andrew Seija, Kaylee E Poole, Kelsey B Stout
BACKGROUND: Overnutrition of saturated fats and fructose is one of the major factors for the development of nonalcoholic fatty liver disease. Because omega-3 polyunsaturated fatty acids (n-3fa) have established lipid lowering properties, we tested the hypothesis that n-3fa prevents high-fat and fructose-induced fatty liver disease in mice. METHODS: Male C57BL/6J mice were randomly assigned to one of the following diet groups for 14 weeks: normal diet (ND), high-fat lard-based diet (HFD), HFD with fructose (HFD + Fru), high-fat fish-oil diet (FOD), or FOD + Fru...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746628/response-to-letter-to-editor
#15
Panakj Puri, Vivek Saraswat
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746627/comments-indian-national-association-for-study-of-the-liver-inasl-guidance-for-antiviral-therapy-against-hcv-infection-update-2016
#16
Sanjay Hadigal
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746626/hepatobiliary-quiz-answers-19-2016
#17
Sahaj Rathi, Radha K Dhiman
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746625/the-long-road-from-obesity-to-atherosclerosis-via-the-liver
#18
Swastik Agrawal
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746624/honeycomb-cyst-of-the-liver
#19
Sunil Taneja, Pramod Kumar, Ajay Duseja, Virendra Singh, Radha K Dhiman, Yogesh Chawla
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746623/iatrogenic-cushing-syndrome-from-interaction-between-ritonavir-and-oral-budesonide-during-direct-acting-antiviral-hepatitis-c-therapy
#20
Sern Wei Yeoh
Direct acting antiviral (DAA) regimens containing ritonavir have been developed to treat hepatitis C, with fewer side effects than that by interferon-based regimens. However prescribers must be aware of drug-drug interactions. There are multiple reports of iatrogenic Cushing syndrome (CS) caused by ritonavir, when used to treat human immunodeficiency virus, increasing the bioavailability of exogenous steroids by inhibiting cytochrome p450 enzymes in the liver and gut wall and thus reducing steroid metabolism...
September 2016: Journal of Clinical and Experimental Hepatology
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