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Journal of Clinical and Experimental Hepatology

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https://www.readbyqxmd.com/read/27746628/response-to-letter-to-editor
#1
Panakj Puri, Vivek Saraswat
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746627/comments-indian-national-association-for-study-of-the-liver-inasl-guidance-for-antiviral-therapy-against-hcv-infection-update-2016
#2
Sanjay Hadigal
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746626/hepatobiliary-quiz-answers-19-2016
#3
Sahaj Rathi, Radha K Dhiman
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746625/the-long-road-from-obesity-to-atherosclerosis-via-the-liver
#4
Swastik Agrawal
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746624/honeycomb-cyst-of-the-liver
#5
Sunil Taneja, Pramod Kumar, Ajay Duseja, Virendra Singh, Radha K Dhiman, Yogesh Chawla
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746623/iatrogenic-cushing-syndrome-from-interaction-between-ritonavir-and-oral-budesonide-during-direct-acting-antiviral-hepatitis-c-therapy
#6
Sern Wei Yeoh
Direct acting antiviral (DAA) regimens containing ritonavir have been developed to treat hepatitis C, with fewer side effects than that by interferon-based regimens. However prescribers must be aware of drug-drug interactions. There are multiple reports of iatrogenic Cushing syndrome (CS) caused by ritonavir, when used to treat human immunodeficiency virus, increasing the bioavailability of exogenous steroids by inhibiting cytochrome p450 enzymes in the liver and gut wall and thus reducing steroid metabolism...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746622/giant-cell-hepatitis-rare-entity-in-adults
#7
Shiran Shetty, Krishnaveni Janarthanan, Venkatakrishnan Leelakrishnan, Vadakkepat Nirmala
Giant-cell hepatitis (GCH) is characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver. Although it is commonly described in neonates, it rarely occurs in adults. Here we report a case of GCH because of herbal medicine intake.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746621/delayed-severe-hemobilia-due-to-bilio-venous-fistula-after-percutaneous-transhepatic-biliary-drainage-treatment-with-covered-stent-placement
#8
Kumble S Madhusudhan, Nihar R Dash, Adil Afsan, Shivanand Gamanagatti, Deep N Srivastava, Arun K Gupta
Biliovenous fistula occurs due to development of a communication between hepatic duct and portal vein branches and is a rare complication of percutaneous transhepatic biliary drainage (PTBD). Most of them are self-limiting and only occasionally they need interventional management. Placement of biliary stent graft is a viable option. We present here a case of a 56-year-old male with carcinoma of gall bladder presenting with hemodynamic shock due to severe hemobilia after PTBD and treated successfully by biliary covered stent placement...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746620/acute-on-chronic-liver-failure-what-is-in-a-definition
#9
REVIEW
Anil C Anand, Radha K Dhiman
Acute on chronic liver failure (ACLF) is a recently recognized syndrome and its definition has been evolving over last two decades. Currently, there is no universal consensus about the definition as kind of cases being seen in the Western world appear to be somewhat different from those that are seen in Asia Pacific region. But every one agrees that definition of ACLF should include following components. (a) The status of pre-existing liver disease, (b) defining the acute insult that leads to rapid deterioration of liver status, (c) time frame during which the acute insult can lead to rapid deterioration, (d) the quantification and definition of liver failure status after deterioration, which will determine the severity of ACLF, and (e) prediction of prognosis after analyzing first four components in the short and long terms...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746619/tackling-the-hepatitis-c-disease-burden-in-punjab-india
#10
REVIEW
Radha K Dhiman, Sandeep Satsangi, Gagandeep S Grover, Pankaj Puri
Hepatitis C virus (HCV) is a globally prevalent pathogen and is a major cause of healthcare burden in India. HCV poses a significant problem in the state of Punjab, India owing to the higher prevalence of risk factors like unsafe medical practices (including unsafe injections and dental procedures) and intravenous drug use. The reported prevalence of HCV in this part of the country was 5.2% in 2012, while a recent study has shown the prevalence to be 3.2% in 2016. Similar to the other geographic belts in India, genotype 3 predominates in the state of Punjab...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746618/polymorphisms-in-ugt1a1-gene-predispose-south-indians-to-pigmentous-gallstones
#11
Vishnubhotla Venkata Ravikanth, Guduru Venkat Rao, Bale Govardhan, Mitnala Sasikala, Chivukula Subramanyam, H V Vivekananda Murthy, Siddapuram Siva Prasad, G Deepika, Rebala Pradeep, Duvvuru Nageshwar Reddy
BACKGROUND/OBJECTIVES: Pigmentous gallstones occur in South Indians despite significant higher levels of circulating cholesterol. This study was conducted to identify the biochemical and/or genetic causes for the formation of pigmentous gallstones in this ethnic group. METHODS: Plasma lipid profile, bile cholesterol, acids, and phospholipid levels were estimated in patients with gall stone disease and age, sex matched controls using standard protocols. Twenty-seven SNPs related to cholesterol and bilirubin metabolism pathway genes were genotyped in the study population using the Sequenom platform...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746617/clinical-significance-of-quantitative-hbsag-titres-and-its-correlation-with-hbv-dna-levels-in-the-natural-history-of-hepatitis-b-virus-infection
#12
Vijay K Karra, Soumya J Chowdhury, Rajesh Ruttala, Sunil K Polipalli, Premashis Kar
BACKGROUND/OBJECTIVE: Quantification of serum hepatitis B antigen (HBsAg) is an important test that marks active infection with hepatitis B and helps in the prediction of the clinical outcome and management of hepatitis B virus (HBV) infection. Correlation with HBV DNA quantitative levels may help in developing strategies for antiviral treatment. This study is aimed to evaluate HBsAg titres in various phase of HBV infection in HBsAg positive patients, and its correlation with HBV DNA viral load levels...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746616/progressive-familial-intrahepatic-cholestasis-pfic-in-indian-children-clinical-spectrum-and-outcome
#13
Sajan Agarwal, Bikrant Bihari Lal, Dinesh Rawat, Archana Rastogi, Kishore G S Bharathy, Seema Alam
OBJECTIVE: To study the clinical and laboratory profile of children with progressive familial intrahepatic cholestasis (PFIC) and evaluate their outcome. METHODS: The study is a retrospective review of all cases diagnosed with PFIC between January 2011 and July 2015. All children underwent histopathological examination and immunostaining. Management was done as per institute's protocol. RESULTS: There were a total of 24 PFIC cases (PFIC 1-2, PFIC 2-19, PFIC 3-3)...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746615/non-invasive-diagnosis-of-oesophageal-varices-using-systemic-haemodynamic-measurements-by-finometry-comparison-with-other-non-invasive-predictive-scores
#14
Kara Rye, Gerri Mortimore, Andrew Austin, Jan Freeman
BACKGROUND/AIMS: Cirrhosis and portal hypertension are characterised by a hyperdynamic circulation, which is independently associated with variceal size. Non-invasive techniques for measurement of systemic haemodynamics are now available. The aim of the study was to prospectively assess the accuracy of systemic haemodynamics measured non-invasively for the detection of oesophageal varices in cirrhotic patients as compared to other currently available non-invasive methods. METHODS: In a study of 29 cirrhotic patients, systemic haemodynamics were studied non-invasively using the Finometer(®) (mean arterial pressure (MAP), cardiac output (CO)/index, heart rate (HR), peripheral vascular resistance) and portal pressure was assessed by hepatic venous pressure gradient...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746614/urinary-metabotyping-of-hepatocellular-carcinoma-in-a-uk-cohort-using-proton-nuclear-magnetic-resonance-spectroscopy
#15
Mohamed I F Shariff, Jin U Kim, Nimzing G Ladep, Mary M E Crossey, Larry K Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen Ryder, Shaun Greer, I Jane Cox, Roger Williams, Elaine Holmes, Kathryn Nash, Simon D Taylor-Robinson
BACKGROUND: Discriminatory metabolic profiles have been described in urinary (1)H nuclear magnetic resonance (NMR) spectroscopy studies of African patients with hepatocellular carcinoma (HCC). This study aimed to assess similarities in a UK cohort, where there is a greater etiological diversity. METHODS: Urine from cirrhosis and HCC patients was analyzed using a 600 MHz (1)H NMR system. Multivariate analysis and median group MR spectra comparison identified metabolite alterations between groups...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746613/hemodynamic-response-to-carvedilol-is-maintained-for-long-periods-and-leads-to-better-clinical-outcome-in-cirrhosis-a-prospective-study
#16
Vijendra Kirnake, Anil Arora, Varun Gupta, Praveen Sharma, Vikas Singla, Naresh Bansal, Mohan Goyal, Romesh Chawlani, Ashish Kumar
BACKGROUND: Non-selective beta-blockers (NSBBs), e.g. propranolol, are recommended for prophylaxis of variceal bleeding in cirrhosis. Carvedilol, a newer NSBB with additional anti-α1-adrenergic activity, is superior to propranolol in reducing portal pressure. Repeated HVPG measurements are required to identify responders to NSBB. We aimed to determine whether a single-time HVPG measurement, using acute-hemodynamic-response-testing, is sufficient to predict long-term response to carvedilol, and whether these responders have better clinical outcome...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746612/silibinin-inhibits-proliferation-and-migration-of-human-hepatic-stellate-lx-2-cells
#17
Devaraj Ezhilarasan, Jonathan Evraerts, Sid Brice, Pedro Buc-Calderon, Sivanesan Karthikeyan, Etienne Sokal, Mustapha Najimi
BACKGROUND: Proliferation of hepatic stellate cells (HSCs) play pivotal role in the progression of hepatic fibrosis consequent to chronic liver injury. Silibinin (SBN), a flavonoid compound, has shown to possess cell cycle arresting potential against many actively proliferating cancers cell lines. The objective of this study was to evaluate the anti-proliferative and cell cycle arresting properties of SBN in rapidly proliferating human hepatic stellate LX-2 cell line. METHODS: LX-2 cells were fed with culture medium supplemented with different concentrations of SBN (10, 50 and 100 μM)...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746611/the-new-inasl-president-a-clinician-par-excellence
#18
EDITORIAL
Ashish Kumar
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27493466/acute-liver-failure-caused-by-hepatitis-a-virus-with-dengue-coinfection
#19
Sunil Taneja, Amritangsu Borakokty, Ajay Duseja, Radha Krishan Dhiman, Yogesh Chawla
No abstract text is available yet for this article.
June 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27493465/hepatobiliary-quiz-answers-18-2016
#20
Sahaj Rathi, Radha K Dhiman
No abstract text is available yet for this article.
June 2016: Journal of Clinical and Experimental Hepatology
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