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Journal of Clinical and Experimental Hepatology

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https://www.readbyqxmd.com/read/29892189/leucopenia-a-rare-extrahepatic-manifestation-of-acute-hepatitis-a
#1
Ankur Gupta, Priyanka Jain
No abstract text is available yet for this article.
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892188/cefazolin-induced-liver-injury-and-hypoprothrombinemia
#2
Ankur Gupta, Anil K Singh, Khursheed Faridi, Priyanka Jain
No abstract text is available yet for this article.
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892187/a-tale-of-two-diseases-or-a-story-of-co-existence-are-obese-individuals-immune-to-alcoholic-liver-disease
#3
Ankur Gupta
No abstract text is available yet for this article.
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892186/a-4-week-old-neonate-with-jaundice-and-hepatosplenomegaly
#4
Geok C Tan, Melissa Stalling, Bonita Fung
No abstract text is available yet for this article.
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892185/endoscopic-ultrasound-eus-guided-fine-needle-aspiration-a-new-modality-to-diagnose-peritoneal-tuberculosis-in-presence-of-decompensated-cirrhosis-a-case-series-and-review-of-literature
#5
Ravi Daswani, Ashish Kumar, Vikas Singla, Gagandeep Kaur, Praveen Sharma, Naresh Bansal, Anil Arora
Background: The gold-standard for diagnosis is growth of Mycobacterium tuberculosis on ascitic fluid or peritoneal culture. Due to the non-specific signs and symptoms of disease, its early diagnosis is difficult, especially in patients with decompensated cirrhosis. The reported sensitivity of ascitic fluid is low and to obtain tissue for peritoneal biopsy in patients with cirrhosis is difficult. Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) is a good alternative to obtain peritoneal tissue for establishing the diagnosis of peritoneal TB...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892184/hepatitis-c-virus-infection-and-vaccine-development
#6
REVIEW
Xuan Guo, Jin-Yi Zhong, Jun-Wen Li
In the twenty-seven years since the discovery of hepatitis C virus (HCV) the majority of individuals exposed to HCV establish a persistent infection, which is a leading cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. In developed nations, the cure rates of HCV infection could be over 90% with direct-acting antiviral (DAA) regimens, which has made the great progress in global eradication. However, the cost of these treatments is so expensive that the patients in developing nations, where the disease burden is the most severe, could not afford it, which highly restricted its access...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892183/ideal-cure-for-hepatitis-b-infection-the-target-is-in-sight
#7
REVIEW
Shrihari A Anikhindi, Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal, Anil Arora
Hepatitis B virus (HBV) is one of the most common causes of liver cirrhosis and hepatocellular carcinoma. Despite recent strides in pharmacotherapy, complete cure of HBV infection still remains an enigma. The biggest obstacle in HBV therapy is clearance of covalently closed circular deoxyribonucleic acid (cccDNA). We discuss about the role of cccDNA in HBV life cycle, efficacy and shortcomings of currently available antivirals as well as promising novel targets to achieve ideal HBV cure.
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892182/endoscopic-cyanoacrylate-glue-injection-in-management-of-gastric-variceal-bleeding-us-tertiary-care-center-experience
#8
Subhash Chandra, Adrian Holm, Rami G El Abiad, Henning Gerke
Background/Aims: Although endoscopic cyanoacrylate glue injection (ECGI) is recommended as first-line treatment for bleeding gastric varices (GV) there is still limited experience with this method in the US. Our aim was to analyze our 10-year experience of ECGI for treatment and prophylaxis of gastric variceal bleeding. Methods: Records of patients undergoing ECGI of GV at our US tertiary care center between 6/2005 and 5/2015 were reviewed. Assessed outcomes were primary hemostasis, early rebleeding during hospitalization, recurrent bleeding during follow-up, eradication and recurrence of GV...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892181/diagnostic-value-of-glypican3-heat-shock-protein-70-and-glutamine-synthetase-in-hepatocellular-carcinoma-arising-in-cirrhotic-and-non-cirrhotic-livers
#9
Preithy Uthamalingam, Ashim Das, Arunanshu Behra, Naveen Kalra, Yogesh Chawla
Background and objectives: Histopathological distinction of various nodular lesions in liver with sufficient sensitivity and specificity is a challenge even in an expert set up. The panel of immunohistochemical markers composed of glutamine synthetase (GS), Glypican3 (GPC3) and heat shock protein 70 (HSP70) was recommended by the International Consensus Group for Hepatocellular Neoplasia group for the differentiation of high grade dysplastic nodule and early hepatocellular carcinoma (HCC)...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892180/role-of-glutathione-s-transferase-m1-and-t1-gene-polymorphism-in-hepatitis-b-related-liver-diseases-and-cryptogenic-cirrhosis
#10
Siddharth Kapahtia, Rajib K Hazam, Mohammad Asim, Vijay K Karra, Soumya J Chowdhury, Bhudev C Das, Premashis Kar
Background and aim: Progression of hepatitis B virus infection (HBV) might be affected by host genetic factors. The present study was undertaken to study the role of glutathione S-transferases (GST)-M1 and T1 gene polymorphisms in different stages of HBV infection: HBV inactive carrier, chronic hepatitis B and cirrhosis, and cryptogenic cirrhosis. Methods: The study population comprised of 170 subjects; 120 cases (HBV inactive carrier, n  = 30; HBV related chronic hepatitis, n  = 30; HBV related cirrhosis, n  = 30; cryptogenic cirrhosis, n  = 30) and 50 unrelated healthy adults without liver disease as controls...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892179/circulating-fibroblast-growth-factor-19-in-portal-and-systemic-blood
#11
Helene Johansson, Lisa-Mari Mörk, Meng Li, Anita L Sandblom, Ingemar Björkhem, Jonas Höijer, Bo-Göran Ericzon, Carl Jorns, Stefan Gilg, Ernesto Sparrelid, Bengt Isaksson, Greg Nowak, Ewa Ellis
Background: Bile acid homeostasis is essential and imbalance may lead to liver damage and liver failure. The bile acid induced intestinal factor fibroblast growth factor 19 (FGF19) has been identified as a key protein for mediating negative feedback inhibition of bile acid synthesis. The aim of the study was to define FGF19 and bile acid concentrations in portal and systemic blood in the fasted and postprandial state. We also addressed the question if physiological portal levels of FGF19 can be extrapolated from the concentration in systemic blood...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892178/prevalence-of-and-factors-associated-with-minimal-hepatic-encephalopathy-in-patients-with-cirrhosis-of-liver
#12
Abhijith Bale, C Ganesh Pai, Shiran Shetty, Girisha Balaraju, Anurag Shetty
Background/objectives: Minimal hepatic encephalopathy (MHE), though highly prevalent, is a frequently underdiagnosed complication of cirrhosis of the liver. Because lack of time is reported as the major reason for non-testing, identifying patients at high risk of MHE would help in targeting them for screening. We aimed to determine the factors associated with MHE to help identify patient subgroups with a higher risk of MHE for targeted screening. Methods: Patients with cirrhosis of liver presenting between April 2015 and November 2016 were included...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892177/acute-on-chronic-liver-failure-in-hospital-predictors-of-mortality-in-icu
#13
Sujay Kulkarni, Mithun Sharma, Padaki N Rao, Rajesh Gupta, Duvvuru N Reddy
Aims: We studied in-hospital predictors of mortality of acute on chronic liver failure (ACLF) in Indian patients. Methods: Patients admitted to the intensive care unit of our institute fulfilling the definition of ACLF based on the Asia-Pacific Association for Study of Liver Disease (APASL) consensus were included. Complete history and medical evaluation to assess the etiology of underlying liver cirrhosis and to identify the acute precipitating insult of worsening liver function was done...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892176/living-donor-liver-transplantation-for-acute-on-chronic-liver-failure-based-on-easl-clif-diagnostic-criteria
#14
Abu Bakar H Bhatti, Faisal S Dar, Muhammad O Butt, Eraj Sahaab, Mohammad Salih, Najmul H Shah, Nusrat Y Khan, Haseeb H Zia, Eitzaz U Khan, Nasir A Khan
Background: The European association for the study of the liver and chronic liver failure consortium (EASL-CLIF) recently proposed diagnostic criteria for acute on chronic liver failure (ACLF). There is lack of data regarding liver transplant outcomes in ACLF patients based on these criteria. The objective of this study was to determine outcome following living donor liver transplantation (LDLT) in ACLF patients. Methods: We retrospectively reviewed patients who underwent LDLT for ACLF based on European association for the study of the liver and chronic liver failure consortium (EASL-CLIF) diagnostic criteria (group 1) ( N  = 60) and compared them with ACLF patients who did not undergo transplantation (group 2) ( N  = 59)...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892175/outcome-of-living-donor-liver-transplantation-for-wilson-s-disease-in-adults-a-single-center-experience
#15
Narendra S Choudhary, Sanjiv Saigal, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Srinivasan Thiagrajan, Dheeraj Gautam, Deepak Govil, Vijay Vohra, Arvinder S Soin
Introduction: Although liver transplantation is a definitive cure for Wilson's disease (WD), there is limited data about results of living donor liver transplantation (LDLT) in adults. Material and methods: 18 adults underwent LDLT for WD. The presentations before LDLT were decompensated cirrhosis ( n  = 16), acute on chronic liver failure ( n  = 1) and acute liver failure ( n  = 1). The donors were parents ( n  = 2), siblings ( n  = 3), cousin ( n  = 1), daughter ( n  = 1), nephew ( n  = 1), spouse or relatives of spouse ( n  = 9) and from swap transplantation ( n  = 1)...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892174/living-donor-liver-transplantation-using-small-for-size-grafts-does-size-really-matter
#16
Pulkit Sethi, Manoj Thillai, Binoj Sivasankarapillai Thankamonyamma, Shweta Mallick, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran Narayana Menon, Sudhindran Surendran, Puneet Dhar, Sudheer Othiyil Vayoth
Background: In living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR) > 0.8% is perceived as the critical graft size. This lower limit of GRWR (0.8%) has been challenged over the last decade owing to the surgical refinements, especially related to inflow and outflow modulation techniques. Our aim was to compare the recipient outcome in small-for-size (GRWR < 0.8) versus normal-sized grafts (GRWR > 0.8) and to determine the risk factors for mortality when small-for-size grafts (SFSG) were used...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892173/efficacy-and-safety-of-sofosbuvir-based-regimens-for-treatment-of-hepatitis-c-recurrence-after-living-donor-liver-transplantation-an-experience-from-india
#17
Narendra S Choudhary, Sanjiv Saigal, Dheeraj Gautam, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Arvinder S Soin
Introduction: Results of Sofosbuvir based regimens for hepatitis C (HCV) recurrence after liver transplantation are available from well-designed clinical trials. Most of the data is from deceased donor liver transplant (DDLT) setting, and data on "real world" experience for HCV recurrence after living donor liver transplantation (LDLT) is limited. Material and methods: Consecutive 78 patients who completed Sofosbuvir based HCV treatment after liver transplantation were included...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892172/sofosbuvir-based-regimen-in-management-of-hepatitis-c-for-patients-with-end-stage-renal-disease-on-hemodialysis-a-single-center-experience-from-india
#18
Ankur Gupta, Puneet Arora, Priyanka Jain
Background: Hepatitis C infection is known to increase the morbidity in patients with end stage renal disease (ESRD). Interferon based treatment is poorly tolerated and has limited cure rates in these patients. In limited available data, sofosbuvir based regimens have been shown to have favorable outcomes in these patients. Methods: We treated 7 patients with ESRD on hemodialysis, 6 with chronic hepatitis C and one with acute hepatitis C. Two of them were cirrhotic of which one was decompensated...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892171/patient-acceptance-of-lactulose-varies-between-indian-and-american-cohorts-implications-for-comparing-and-designing-global-hepatic-encephalopathy-trials
#19
Sahaj Rathi, Andrew Fagan, James B Wade, Madhu Chopra, Melanie B White, Dinesh Ganapathy, Chathur Acharya, Radha K Dhiman, Jasmohan S Bajaj
Background: Lactulose is the first-line drug for hepatic encephalopathy (HE), but its acceptance widely differs between Western and Eastern studies. Patient preference for lactulose between different parts of the world has not been examined systematically. Aim: To define the preferences and reasons behind acceptance of lactulose in patients from USA and India. Methods: A discrete-choice questionnaire with six hypothetical scenarios was constructed...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743803/portal-hypertension-in-a-patient-with-recurrent-pancreatic-cancer-after-radiotherapy-and-systemic-chemotherapy
#20
Xingshun Qi, Ji Feng, Xiaodong Shao, Ying Xu, Hongyu Li, Xiaozhong Guo
No abstract text is available yet for this article.
March 2018: Journal of Clinical and Experimental Hepatology
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