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Journal of Clinical and Experimental Hepatology

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https://www.readbyqxmd.com/read/29743803/portal-hypertension-in-a-patient-with-recurrent-pancreatic-cancer-after-radiotherapy-and-systemic-chemotherapy
#1
Xingshun Qi, Ji Feng, Xiaodong Shao, Ying Xu, Hongyu Li, Xiaozhong Guo
No abstract text is available yet for this article.
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743802/upper-gastrointestinal-bleed-due-to-invasive-hepatocellular-carcinoma-and-hepato-gastric-fistula
#2
Abhijith Bale, Shiran Shetty, Anurag Shetty, Girisha Balaraju, Cannanore Ganesh Pai
No abstract text is available yet for this article.
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743801/acute-exacerbation-to-autoimmune-hepatitis-mimicking-acute-viral-hepatitis-a-case-series-and-review-of-literature
#3
Sunil Taneja, Pramod Kumar, Suvradeep Mitra, Ajay Duseja, Ranjana Minz, Ashim Das, Radha K Dhiman, Yogesh Chawla
Background: Acute exacerbation of Autoimmune Hepatitis (AIH) poses a significant challenge for diagnosis as it can mimic acute viral hepatitis especially in absence of autoantibodies and hypergammaglobulinemia. Aim: To determine the clinical, laboratory, histopathological characteristics and response to treatment in AIH patients with acute exacerbation. Methods: A retrospective analysis of 16 patients with acute exacerbation of AIH diagnosed over a period of eight years (2008-2016)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743800/a-case-of-acute-on-chronic-liver-failure-aclf-due-to-an-uncommon-acute-and-chronic-event
#4
Swastik Agrawal, Baldev S Rana, Suvradeep Mitra, Ajay Duseja, Ashim Das, Radha K Dhiman, Yogesh Chawla
Acute on Chronic Liver Failure (ACLF) is an acute worsening of patients with chronic liver disease resulting in liver failure. Usually these patients have cirrhosis as the underlying liver disease with alcohol being the most common etiology. Common hepatitic illnesses causing acute worsening in Indian patients of ACLF include alcoholic hepatitis, acute viral hepatitis related to hepatitis E virus and acute flare in chronic hepatitis B. We report an adult case of ACLF due acute viral hepatitis related to hepatitis A virus infection superimposed on nonalcoholic steatohepatitis without cirrhosis...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743799/advances-in-hcv-and-cryoglobulinemic-vasculitis-in-the-era-of-daas-are-we-at-the-end-of-the-road
#5
REVIEW
Chalermrat Bunchorntavakul, Robert Mitrani, K Rajender Reddy
Hepatitis C Virus (HCV)-related Mixed Cryoglobulinemia (MC) is a unique condition with complex pathogenesis that involves HCV antigen-driven B-lymphocyte clonal proliferation and mutagenesis. Clinical spectrum of MC ranges from asymptomatic state to clinically-apparent vasculitis involving multiple organs. In the era of Direct-Acting Antiviral (DAA) therapy, patients with HCV-related MC achieve high rates of viral clearance that is commonly accompanied by an improvement in clinical symptoms as well as immunological profiles...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743798/inasl-position-statements-on-prevention-diagnosis-and-management-of-hepatitis-b-virus-infection-in-india-the-andaman-statements
#6
REVIEW
Anil Arora, Shivaram P Singh, Ashish Kumar, Vivek A Saraswat, Rakesh Aggarwal, Manisha Bangar, Pradip Bhaumik, Harshad Devarbhavi, Radha K Dhiman, Vinod K Dixit, Ashish Goel, Bhabadev Goswami, Dharmesh Kapoor, Kaushal Madan, Jimmy Narayan, Sandeep Nijhawan, Gaurav Pandey, Ramesh R Rai, Manoj K Sahu, Neeraj Saraf, Shalimar, Thrivikrama Shenoy, Varghese Thomas, Manav Wadhawan
Hepatitis B Virus (HBV) infection is one of the major causes of morbidity, mortality and healthcare expenditure in India. There are no Indian consensus guidelines on prevention, diagnosis and management of HBV infection. The Indian National Association for Study of the Liver (INASL) set up a taskforce on HBV in 2016, with a mandate to develop consensus guidelines for diagnosis and management of HBV infection, relevant to disease patterns and clinical practices in India. The taskforce first identified contentious issues on various aspects of HBV management, which were allotted to individual members of the taskforce who reviewed them in detail...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743797/natural-history-of-cirrhosis-of-liver-after-first-decompensation-a-prospective-study-in-india
#7
Apurva S Shah, Deepak N Amarapurkar
Background and aims: As liver cirrhosis is a dynamic condition, it is possible to improve survival in decompensated cirrhosis. Hence, we planned a prospective study to determine the natural history of cirrhosis after first decompensation. Methods: We enrolled all patients of liver cirrhosis who presented with first episode of decompensation defined by the presence of ascites, either overt or detected by Ultrasonography (UD), Gastroesophageal Variceal Bleeding (GEVB), and Hepatic Encephalopathy (HE)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743796/increased-incidence-of-post-transplant-lymphoproliferative-disorder-in-autoimmune-liver-disease-an-irish-national-experience
#8
Ahmed Abu-Shanab, Yasser Ged, Naeem Ullah, Diarmaid Houlihan, Aiden McCormick
Background: Post-Transplant Lymphoproliferative Disorder (PTLD) is a well-recognized complication post solid organs transplant. PTLD represents a broad spectrum of abnormalities ranging from an infectious mononucleosis like illness to malignant lymphoma. Methods: A retrospective study was performed by collecting data of orthotopic liver transplant (OLT) patients in the National Liver Unit in Ireland from December 1993 to December 2014. Data was analyzed to identify PTLD patients and determine their demographic details, the indication for liver transplant, presenting symptoms, immunosuppression regimens, Epstein"Barr virus (EBV) status and PTLD outcome...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743795/prevalence-and-impact-of-bacterial-infections-in-children-with-liver-disease-a-prospective-study
#9
Rishi Bolia, Anshu Srivastava, Rungmei Marak, Surender K Yachha, Ujjal Poddar
Background and aims: Risk of infections is increased in patients with Acute Liver Failure (ALF) and Decompensated Chronic Liver Disease (DCLD). We evaluated the frequency, site, type and risk-factors for bacterial infections in children with ALF and DCLD and its effect on outcome. Methods: ALF or DCLD children were enrolled prospectively. Clinical and laboratory details were recorded. Cultures (blood, urine and ascites) and chest X-ray were done at admission followed by weekly surveillance cultures...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743794/role-of-indocyanine-green-in-predicting-post-transarterial-chemoembolization-liver-failure-in-hepatocellular-carcinoma
#10
Shalimar, Sushil Jain, Shivanand R Gamanagatti, Saurabh Kedia, Bhaskar Thakur, Baibaswata Nayak, Harpreet Kaur, Deepak Gunjan, Shashi B Paul, Subrat K Acharya
Background/aim: Post-Transarterial Chemoembolization (TACE) Liver Failure (LF) is common in patients with Hepatocellular Carcinoma (HCC). No definitive objective parameters predict its occurrence. We assessed the role of Indocyanine Green (ICG) in prediction of post-TACE LF. Methods: Consecutive HCC patients with Child A/B class, categorized as Barcelona Clinic Liver Cancer (BCLC) staging A/B, were included between August 2012 and July 2014. All underwent ICG dynamics: Plasma Disappearance Rate (PDR) was recorded on the day of TACE...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743793/bone-health-and-impact-of-tenofovir-treatment-in-men-with-hepatitis-b-related-chronic-liver-disease
#11
Kattiparambil G Sajith, Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E Eapen, Thomas V Paul
Background: Chronic Liver Disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton. Objective: To study the impact of HBV related CLD and its treatment with Tenofovir on bone health in Indian subjects. Methods: This cross sectional study included men (18-60 years) and comprised of three groups: Group-1 was treatment naïve HBV related CLD ( n  = 79), Group-2 those with HBV related CLD on tenofovir for at least 1 year ( n  = 136), Group-3 age, sex and Body Mass Index (BMI) matched healthy controls ( n  = 58)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743792/effect-of-sofosbuvir-plus-daclatasvir-in-hepatitis-c-virus-genotype-4-patients-promising-effect-on-liver-fibrosis
#12
Asmaa M Abdel-Aziz, Mohamed A Ibrahim, Azza A El-Sheikh, Maha Y Kamel, Nagwa M Zenhom, Salam Abdel-Raheim, Hisham Abdelhaleem
Background/purpose: The effect of sofosbuvir and daclatasvir in treatment of genotype 4 Hepatitis C Virus (HCV) is not well documented. This study investigated the safety and efficacy of sofosbuvir plus daclatasvir with or without ribavirin in treatment of HCV genotype 4 patients. The impact of therapy on liver fibrosis as well as the role of IL18 polymorphism in therapeutic outcome was assessed. Methods: One hundred HCV genotype 4 patients were categorized into 2 groups...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743791/impact-of-direct-acting-antiviral-therapy-for-treatment-of-hepatitis-c-genotypes-1-3-and-4-a-real-life-experience-from-india
#13
Varun Mehta, Ramit Mahajan, Vandana Midha, Vikram Narang, Kirandeep Kaur, Arshdeep Singh, Anand Malhotra, Aslam Parvez, Ajit Sood
Objective: To assess impact of Direct Acting Antiviral (DAA) therapies for treatment of Hepatitis C Virus (HCV) genotypes 1, 3 and 4 in a real-world cohort from India. Methods: Adults with chronic HCV infection treated with Sofosbuvir (SOF) and Ledipasvir (LDV) (genotypes 1 and 4) or SOF and Daclatasvir (DCV) (genotype 3), with or without Ribavirin (RBV) between December 2015 and December 2016 were included. The primary endpoint was Sustained Virological Response at Post-treatment Week 12 (SVR12)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743790/safety-and-efficacy-of-sofosbuvir-and-daclatasvir-for-hepatitis-c-virus-infection-in-patients-with-%C3%AE-thalassemia-major
#14
Rajiv Mehta, Mayank Kabrawala, Subhash Nandwani, Pankaj Desai, Vishwa Bhayani, Sanjay Patel, Viral Parekh
Background and Aims: β-thalassemia major patients are susceptible to Hepatitis C Virus (HCV) infection owing to life-long dependency for blood-transfusion. Moreover, this patient population is at risk of progression of liver fibrosis or development of cirrhosis as a consequence of both iron overload and HCV infection. Hence, this study was carried out to evaluate efficacy and safety of the combination regimen of sofosbuvir and daclatasvir for HCV infection in β-thalassemia major patients...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743789/direct-acting-antiviral-agents-for-hcv-infection
#15
EDITORIAL
Madhumita Premkumar, Radha K Dhiman
No abstract text is available yet for this article.
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234206/large-heterogeneous-calcified-masses-in-liver-a-diagnostic-dilemma
#16
Nidhi Prabhakar, Naveen Kalra, Arunanshu Behera, Ashim Das, Anupam Lal, Radha Krishan Dhiman, Niranjan Khandelwal
No abstract text is available yet for this article.
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234205/a-rare-case-of-primary-sarcomatous-hepatocellular-carcinoma-without-previous-anticancer-therapy
#17
Suvradeep Mitra, Saumya Gupta, Divya Dahiya, Uma N Saikia
Primary sarcomatous hepatocellular carcinoma (PSHCC) is a rare and aggressive variety of hepatocellular carcinoma (HCC). The recent evidence suggests that anticancer therapy promotes the dedifferentiation of the carcinomatous component and is largely responsible for this aggressive variant of HCC. However, in the absence of any anticancer therapy, occurrence of PSHCC is extremely rare. Herein, we present a rare case report of a 65 year old male patient, with a hepatitis B positive status, presenting with PSHCC without any history of anticancer therapy...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234204/middle-hepatic-vein-bleed-during-donor-hepatectomy-technique-for-safe-practice
#18
Madhusudhanan Jegadeesan, Neerav Goyal, Subash Gupta
Safe performance of donor hepatectomy is crucial for sustainability of a living donor liver transplantation (LDLT) program. Middle hepatic vein (MHV) is always encountered during parenchymal transection irrespective of right or left donor hepatectomies. Here we present a safe and effective technique for tackling MHV bleed during LDLT from a single centre experience.
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234203/cholemic-or-bile-cast-nephropathy-in-a-child-with-liver-failure
#19
Vikrant Sood, Bikrant B Lal, Suman Lata, Archana Rastogi, Seema Alam
Cholemic or bile cast nephropathy is an under-reported entity characterized by acute renal dysfunction in patients with hepatic insult. Limited literature is available regarding its clinical presentation, pathogenesis and prognosis. We hereby present a pediatric case who presented with acute on chronic liver failure with renal dysfunction secondary to cholemic nephropathy.
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234202/matrix-metalloproteinases-mmps-in-liver-diseases
#20
REVIEW
Adnan Naim, Qiuwei Pan, Mirza S Baig
Matrix metalloproteinases (MMPs) are proteinases capable of degrading components of the extracellular matrix and numerous nonmatrix proteins. MMPs along with tissue inhibitors of MMPs, have been implicated in the pathogenesis of liver diseases. Although, the precise mechanism-of-actions of MMPs in various liver related disorders is largely unknown, however, data from diverse experimental models indicate that these proteinases influence cellular activities including proliferation and survival, gene expression, as well as multiple aspects of inflammation...
December 2017: Journal of Clinical and Experimental Hepatology
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