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Human Vaccines & Immunotherapeutics

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https://www.readbyqxmd.com/read/28085544/identification-of-immunoglobulin-v-d-j-recombinations-in-solid-tumor-specimen-exome-files-evidence-for-high-level-b-cell-infiltrates-in-breast-cancer
#1
Wei Lue Tong, Yaping N Tu, Mohammad D Samy, Wade J Sexton, George Blanck
It has recently become apparent that it is possible to characterize productively recombined, T-cell receptor (TcR) gene segments in tumor exome files, which presumably include representations of the DNA of other cells in the microenvironment. Similar characterizations have been done for TcR recombinations in tumor specimen RNASeq files. While exome files have been used to characterize immunoglobulin gene segment recombinations for tumors closely related to B-cells, immunoglobulin recombinations have yet to be characterized for putative microenvironment cells for solid tumors...
January 13, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28075671/hospitalization-rates-for-intussusception-in-children-aged-0-59%C3%A2-months-from-2009-to-2014-in-italy
#2
Vincenzo Restivo, Claudio Costantino, Fabio Tramuto, Francesco Vitale
The real cause of intussusception is not fully understood and a variety of conditions have been associated with it (Meckel diverticulum, polyps, duplication cysts, parasites, Henoch-Schönlein purpura, cystic fibrosis, hemolytic-uremic syndrome and infectious gastroenteritis). Furthermore few European countries, following WHO recommendation to monitor baseline incidence of intussusception before implementation of immunization program for rotavirus, used intussusception rate as a baseline value to compare the same figures in the period before and after introduction of vaccination...
January 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28075249/cost-effectiveness-analysis-of-as04-adjuvanted-human-papillomavirus-16-18-vaccine-compared-with-human-papillomavirus-6-11-16-18-vaccine-in-the-philippines-with-the-new-2-dose-schedule
#3
Maria Julieta Germar, Carrie Purugganan, Ma Socorro Bernardino, Benjamin Cuenca, Y-Chen Chen, Xiao Li, Georges Van Kriekinge, I-Heng Lee
Cervical cancer (CC) is the second leading cause of cancer death among Filipino women. Human papillomavirus (HPV) vaccination protects against CC. Two vaccines (AS04-HPV-16/18 and 4vHPV) are approved in the Philippines; they were originally developed for a 3-dose (3 D) administration and have recently been approved in a 2-dose schedule (2 D). This study aims to evaluate the cost-effectiveness and budget impact of HPV vaccination of 13-year-old Filipino girls, in addition to current screening, in the new 2 D schedule...
January 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28068212/immunogenicity-and-safety-of-an-adjuvanted-herpes-zoster-subunit-candidate-vaccine-in-adults-%C3%A2-50%C3%A2-years-of-age-with-a-prior-history-of-herpes-zoster-a-phase-iii-non-randomized-open-label-clinical-trial
#4
Olivier Godeaux, Martina Kovac, Daniel Shu, Katrijn Grupping, Laura Campora, Martine Douha, Thomas C Heineman, Himal Lal
This phase III, non-randomized, open-label, multi-center study (NCT01827839) evaluated the immunogenicity and safety of an adjuvanted recombinant subunit herpes zoster (HZ) vaccine (HZ/su) in adults aged ≥50 years with prior physician-documented history of HZ. Participants (stratified by age: 50-59, 60-69 and ≥70 years) received 2 doses of HZ/su 2 months apart and were followed-up for another 12 months. Anti-glycoprotein E (gE) antibodies were measured by enzyme-linked immunosorbent assay before vaccination and 1 month after the second dose (Month 3)...
January 9, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28068211/cost-analysis-of-measles-in-refugees-arriving-at-los-angeles-international-airport-from-malaysia
#5
Margaret S Coleman, Heather M Burke, Bethany L Welstead, Tarissa Mitchell, Eboni M Taylor, Dmitry Shapovalov, Brian A Maskery, Heesoo Joo, Michelle Weinberg
Background On August 24, 2011, 31 U.S.-bound refugees from Kuala Lumpur, Malaysia (KL) arrived in Los Angeles. One of them was diagnosed with measles post-arrival. He exposed others during a flight, and persons in the community while disembarking and seeking medical care. As a result, nine cases of measles were identified. Methods We estimated costs of response to this outbreak and conducted a comparative cost analysis examining what might have happened had all U.S.-bound refugees been vaccinated before leaving Malaysia...
January 9, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059676/struggles-within-japan-s-national-hpv-vaccination-a-proposal-for-future-strategy
#6
Yusuke Tanaka, Yutaka Ueda, Tadashi Kimura
No abstract text is available yet for this article.
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059670/mycobacterial-hsp65-antigen-upregulates-the-cellular-immune-response-of-healthy-individuals-compared-to-tuberculosis-patients
#7
Pryscilla Fanini Wowk, Luís Henrique Franco, Denise Morais Fonseca, Marina Oliveira Paula, Élcio Dos Santos Oliveira Vianna, Ana Paula Wendling, Valéria Maria Augusto, Silvana Maria Elói-Santos, Andréa Teixeira-Carvalho, Flávia Dias Coelho Silva, Solange Alves Vinhas, Olindo Assis Martins-Filho, Moisés Palaci, Célio Lopes Silva, Vânia Luiza Deperon Bonato
Previously we showed that 65-kDa Mycobacterium leprae heat shock protein (Hsp65) is a target for the development of a tuberculosis vaccine. Here we evaluated peripheral blood mononuclear cells (PBMC) from healthy individuals or tuberculosis patients stimulated with two forms of Hsp65 antigen, recombinant DNA that encodes Hsp65 (DNA-HSP65) or recombinant Hsp65 protein (rHsp65) in attempting to mimic a prophylactic or therapeutic study in vitro, respectively. Proliferation and cytokine-producing CD4(+) or CD8(+) cell were assessed by flow cytometry...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059668/vaccinating-healthcare-workers-level-of-implementation-barriers-and-proposal-for-evidence-based-policies-in-turkey
#8
Lale Ozisik, Mine Durusu Tanriover, Serdar Altınel, Serhat Unal
The role of healthcare workers in life-long vaccination is very important in the means of two sided infection, rising patient awareness and being a role model for the patients. Numerous organizations publish guidelines for vaccination of HCWs, while healthcare facilities develop vaccination policies according to the accreditation standards. Nevertheless, vaccination rates among HCWs are far below targets. The obstacles to getting vaccinated or recommending vaccination may include rather universal factors such as the vaccine paradox, however in the case of HCWs, probably a different set of factors are included...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059665/efficacy-of-phase-3-trial-of-rts-s-as01-malaria-vaccine-in-infants-a-systematic-review-and-meta-analysis
#9
Shima Mahmoudi, Hossein Keshavarz
Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate is RTS,S, a pre-erythrocytic vaccine for which pivotal phase III trial design is underway. Few recent malaria vaccine review articles have attempted to outline of all clinical trials that have occurred globally and no meta-analysis was performed on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria vaccine up to now in infants...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059628/community-wide-measles-outbreak-in-the-region-of-madrid-spain-10%C3%A2-years-after-the-implementation-of-the-elimination-plan-2011-2012
#10
L García Comas, M Ordobás Gavín, J C Sanz Moreno, B Ramos Blázquez, E Rodríguez Baena, E Córdoba Deorador, M García Barquero, E Gil Montalbán, A Arce Arnáez, I Rodero Garduño, D Barranco Ordóñez, J Astray Mochales
We describe a community-wide outbreak of measles due to a D4 genotype virus that took place in the Region of Madrid, Spain, between February 2011 and August 2012, along with the control measures adopted. The following variables were collected: date of birth, sex, symptoms, complications, hospital admission, laboratory test results, link with another cases, home address, places of work or study, travel during the incubation period, ethnic group, and Mumps-Measles-Rubella (MMR) vaccination status. Incidences were calculated by 100,000 inhabitants...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059624/pre-clinical-development-of-gene-modification-of-hematopoietic-stem-cells-with-chimeric-antigen-receptors-for-cancer-immunotherapy
#11
Sarah M Larson, Laurel C Truscott, Tzu-Ting Chiou, Amie Patel, Roy Kao, Andy Tu, Tulika Tyagi, Xiang Lu, David Elashoff, Satiro N De Oliveira
Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of hematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) will produce a multi-lineage, persistent immunotherapy against B-lineage malignancies that can be controlled by the HSVsr39TK suicide gene. High-titer third-generation self-inactivating lentiviral constructs were developed to deliver a second-generation CD19-specific CAR and the herpes simplex virus thymidine kinase HSVsr39TK to provide a suicide gene to allow ablation of gene-modified cells if necessary...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059619/comparison-of-iatrogenic-pain-between-rotavirus-vaccination-before-and-after-vaccine-injection-in-2-month-old-infants
#12
Hui-Chu Yin, Whei-Mei Shih, Hsiu-Lan Lee, Huei-Jing Yang, Yu-Li Chen, Shao-Wen Cheng, Chun-Yuh Yang, Ya-Wen Chiu, Yi-Hao Weng
Oral rotavirus vaccine (RV) administration in conjunction with other injectable vaccines has been used worldwide. However, whether the sequence of RV administration is associated with the reduction of injection-induced pain remains unclear. In this randomized controlled trial, we enrolled 6-12-wk-old healthy infants. The pain response of the infants was scored on the basis of their crying, irritability, facial expression, gagging and distress. A multivariate logistic regression model was used to compare the pain response after adjustment for possible confounders...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059613/seroprevalence-of-poliovirus-antibodies-in-the-kansas-city-metropolitan-area-2012-2013
#13
Gregory S Wallace, Barbara A Pahud, William C Weldon, Aaron T Curns, M Steven Oberste, Christopher J Harrison
No indigenous cases of poliomyelitis have occurred in the U.S. since 1979; however the risk of importation persists until global eradication is achieved. The seropositivity rate for different age cohorts with exposures to different poliovirus vaccine types and wild virus in the U.S. are not presently known. A convenience sample was conducted in the Kansas City metropolitan area during 2012-2103 with approximately 100 participants enrolled for each of 5 age cohorts categorized based on vaccine policy changes over time in the U...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059610/readyvax-a-new-mobile-vaccine-information-app
#14
Robert A Bednarczyk, Paula M Frew, Daniel A Salmon, Ellen Whitney, Saad B Omer
Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (including parents of children). We describe the information content and technical development of ReadyVax. Between the hard launch of the app on February 12, 2015 and October 8, 2016, the app has been downloaded by 5,142 unique users, with 6,841 total app sessions initiated, comprising a total of 15,491 screen views (2...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059609/rotavirus-specific-maternal-antibodies-and-immune-response-to-rv3-bb-neonatal-rotavirus-vaccine-in-new-zealand
#15
Mee-Yew Chen, Carl D Kirkwood, Julie Bines, Daniel Cowley, Daniel Pavlic, Katherine J Lee, Francesca Orsini, Emma Watts, Graeme Barnes, Margaret Danchin
Background Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccine observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time of the study rotavirus vaccines had not been introduced in New Zealand and the burden of rotavirus disease was evident...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059608/near-future-of-tumor-immunology-anticipating-resistance-mechanisms-to-immunotherapies-a-big-challenge-for-clinical-trials
#16
João Paulo Portela Catani, Sandy Adjemian, Rachel P Riechelmann, Bryan E Strauss
The success of immunotherapies brings hope for the future of cancer treatment. Even so, we are faced with a new challenge, that of understanding which patients will respond initially and, possibly, develop resistance. The examination of the immune profile, especially approaches related to the immunoscore, may foretell which tumors will have a positive initial response. Ideally, the mutation load would also be analysed, helping to reveal tumor associated antigens that are predictive of an effective cytolytic attack...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059607/influences-of-obesity-on-the-immunogenicity-of-hepatitis-b-vaccine
#17
Fang Liu, Zhirong Guo, Chen Dong
OBJECTIVE: Hepatitis B vaccine is regarded as the most effective method for the prevention of hepatitis B virus (HBV) infection. However, several factors such as age, body mass index and immunocompetent state have been reported to be associated with reduced immunization responses. The present commentary was aimed to discuss the influences of obesity on the immunogenicity of hepatitis B vaccines. DATA SOURCES: Available peer-reviewed literatures, practice guidelines, and statistics published on hepatitis B vaccine in obesity between 1973 and 2015...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28051903/the-immunogenicity-of-thin-film-freeze-dried-aluminum-salt-adjuvanted-vaccine-when-exposed-to-different-temperatures
#18
Sachin G Thakkar, Tinashe B Ruwona, Robert O Williams, Zhengrong Cui
Insoluble aluminum salts such as aluminum oxyhydroxide have been used for decades as adjuvants in human vaccines, and many vaccines contain aluminum salts as adjuvants. Aluminum salt-adjuvanted vaccines must be managed in cold-chain (2-8°C) during transport and storage, as vaccine antigens in general are too fragile to be stable in ambient temperatures, and freezing causes irreversible aggregation and permanent damage to the vaccines. Previously, we reported that thin-film freeze-drying can be used to convert vaccines adjuvanted with an aluminum salt from liquid suspension into dry powder without causing particle aggregation or decreasing in immunogenicity following reconstitution...
January 4, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28045585/immunogenicity-and-safety-of-purified-vero-cell-rabies-vaccine-pvrv-under-zagreb-2-1-1-or-5-dose-essen-regimen-in-chinese-adults-aged-50-and-above
#19
Jing Wang, FengJi Luo, ZiJian Feng, Li Li, YunHua Bai, Xing Ai, JianXin Ma, Zheng Zhang, NianMin Shi
BACKGROUND: Two kinds of regimens (2-1-1 and 1-1-1-1-1) can be selected after Zagreb regimen(2-1-1)of PVRV was officially approved in Beijing in January 2015. Up to now, the subjects for most studies about the comparison between Zagreb and Essen regimen are under 50 years old, rarely at and above. Aging of the immune system may result in decreasing efficacy of vaccination, especially for adults aged above 65-70 years. This study compared the safety and immunogenicity of the Zagreb and Essen regimen in Chinese adults aged 50 and above with the goal to provide a supplemental data for this age group...
January 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28045580/immune-persistence-after-pertussis-vaccination
#20
Zhiyun Chen, Qiushui He
Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs due to variation in vaccine content, schedule and coverage. Protection following acellular pertussis vaccines has been suggested to wane faster than whole cell pertussis vaccines. However, long-term immune persistence of whole cell pertussis vaccines may be confounded by a progressive acquisition of natural immunity...
January 3, 2017: Human Vaccines & Immunotherapeutics
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