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Human Vaccines & Immunotherapeutics

Lili Huang, Ling Wang, Hong Li, Yuansheng Hu, Weiping Ru, Weixiao Han, Gang Shi, Qiang Ye, Zhen Han, Jielai Xia, Shengli Xia, Miao Xu, Jing Li
To evaluate the safety and immunogenicity of a newly 23-valent pneumococcal polysaccharide vaccine (PPV23), a phase Ⅲ clinical trial was conducted in population aged ≥ 2 years. We conducted a randomized, double-blinded, active controlled trial, in which 1760 participants were randomly assigned in a 1:1 ratio to receive one dose of either the test vaccine or the control commercial vaccine. The surveillance period was 28 days. The 2-fold increase rate of anti-pneumococcal for 23 serotypes varied from 49...
September 14, 2018: Human Vaccines & Immunotherapeutics
A Gurtman, E Begier, N Mohamed, J Baber, C Sabharwal, R M Haupt, H Edwards, D Cooper, K U Jansen, A S Anderson
Staphylococcus aureus (S. aureus) is a challenging bacterial pathogen which can cause a range of diseases, from mild skin infections, to more serious and invasive disease including deep or organ space surgical site infections, life-threatening bacteremia, and sepsis. S. aureus rapidly develops resistance to antibiotic treatments. Despite current infection control measures, the burden of disease remains high. The most advanced vaccine in clinical development is a 4 antigen S. aureus vaccine (SA4Ag) candidate that is being evaluated in a phase 2b/3 efficacy study in patients undergoing elective spinal fusion surgery (STaphylococcus aureus suRgical Inpatient Vaccine Efficacy [STRIVE])...
September 14, 2018: Human Vaccines & Immunotherapeutics
Miguel F Carvalho, Davinder Gill
The difference noted in Rotavirus vaccine efficiency between high and low income countries correlates with the lack of universal access to clean water and higher standards of hygiene. Overcoming these obstacles will require great investment and also time, therefore more effective vaccines should be developed to meet the needs of those who would benefit the most from them. Increasing our current knowledge of mucosal immunity, response to Rotavirus infection and its modulation by circadian rhythms could point at actionable pathways to improve vaccination efficacy, especially in the case of individuals affected by environmental enteropathy...
September 14, 2018: Human Vaccines & Immunotherapeutics
Marie Paule Kieny
No abstract text is available yet for this article.
September 14, 2018: Human Vaccines & Immunotherapeutics
Jennifer A Pereira, Vladimir Gilca, Nancy Waite, Melissa K Andrew
Influenza vaccination is an important public health intervention for older adults, yet vaccination rates remain suboptimal. We conducted an online survey of Canadians ≥ 65 years to explore satisfaction with publicly-funded standard-dose influenza vaccines, and perceptions of the need for a more effective product. They were provided with information about currently approved influenza vaccines, and were asked about their preferences should all formulations be available for free, and should the recently approved high-dose (HD) vaccine for seniors be available at a cost...
September 11, 2018: Human Vaccines & Immunotherapeutics
Knut Reidar Wangen, Dawei Zhu, Jian Wang
Hepatitis B vaccination rates in China have recently increased. This study aimed to investigate infant vaccination coverage for birth cohorts from 1997 to 2011 in rural regions and to assess catch-up vaccination potential. We used questionnaire-based interviews from a cross-section of 6,529 individuals from seven provinces. Logistic regression analyses were used to model two measures of infant vaccination status, namely, birth dose within 24 hours and three doses within the first year of life. During interviews, individuals' vaccination status and vaccination plan were recorded...
September 10, 2018: Human Vaccines & Immunotherapeutics
Min Zhou, Lindu Zhao, Nan Kong, Kathryn S Campy, Song Wang, Shujuan Qu
Parental behavioral intentions play a key role in children vaccination. The present study looks at how parental expectations for the vaccination influence their attitudes and behavioral intentions toward children's immunization. The theoretical model is developed on TPB model and empirically tested with sample data from 380 children aged 0-7 years in mainland China. The structural equation modeling and multi-group analysis were used in the model to demonstrate the impact of the vaccination services quality, vaccination promotions and public opinions on attitudes and vaccination behavioral intention...
September 10, 2018: Human Vaccines & Immunotherapeutics
Julia E Painter, Suyane Viana De O Mesquita, Lauren Jimenez, Arturo A Avila, Caroline J Sutter, Rebecca Sutter
Uninsured Latin American immigrant women are at increased risk for vaccine preventable diseases, such as cervical cancer; yet gaps in vaccine coverage persist. The purpose of this study was to explore vaccine-related knowledge, attitudes and decision-making for tetanus, diphtheria, and acellular pertussis (Tdap) vaccine, meningococcal conjugate vaccine (MenACWY), and human papillomavirus (HPV) vaccine among uninsured Latin American immigrant mothers of adolescent daughters. A purposive sample of 30 low-income, uninsured, predominantly Latin-American immigrant mothers of adolescent daughters aged 13-17 were recruited from two academic-community managed health clinics in Virginia...
September 10, 2018: Human Vaccines & Immunotherapeutics
Vishal Bhagwan Badgujar, Fatin Shahirah Ahmad Fadzil, Helvinder Kaur Balbir Singh, Farheen Sami, Sangita Badgujar, Mohammed Tahir Ansari
The human papilloma virus (HPV) is known to be a major causative agent of cervical cancers and warts, limited study has been conducted on its associated factors among health care students and professionals in Malaysia. The present study was carried to explore the knowledge, understanding, attitude, perception and views about HPV infection and vaccination. A total of 576 respondents were recruited to complete a self-administered questionnaire through convenience sampling across Malaysia. 80.% and of the females respondents exhibited a positive attitude towards knowledge and understanding and 60% exhibited a positive towards attitude, perception and views...
September 10, 2018: Human Vaccines & Immunotherapeutics
San Jiun Chai, Sammuel Chee Yong Fong, Chai Phei Gan, Kin Choo Pua, Paul Vey Hong Lim, Shin Hin Lau, Rosnah Binti Zain, Thomas Abraham, Siti Mazlipah Ismail, Zainal Ariff Abdul Rahman, Sathibalan Ponniah, Vyomesh Patel, Sok Ching Cheong, Kue Peng Lim
Peptide vaccines derived from tumour-associated antigens have been used as an immunotherapeutic approach to induce specific cytotoxic immune response against tumour. We previously identified that MAGED4B and FJX1 proteins are overexpressed in HNSCC patients; and further demonstrated that two HLA-A2-restricted 9-11 amino acid peptides derived from these proteins were able to induce anti-tumour immune responses in vitro independently using PBMCs isolated from these patients. In this study, we evaluated the immunogenicity and efficacy of a dual-antigenic peptide vaccine (PV1), comprised of MAGED4B and FJX1 peptides in HNSCC patients...
September 7, 2018: Human Vaccines & Immunotherapeutics
Ana Clara Zoni, María D Esteban-Vasallo, M Felicitas Domínguez-Berjón, Juan Manuel Sendra, Jenaro Astray-Mochales
Annual influenza vaccination is considered the best protection against influenza infection. We analyzed the influenza vaccine coverage (IVC) in cystic fibrosis (CF) patients and evaluated the factors associated with the IVC, including the effect of text-message/SMS reminders. We performed a cross-sectional study in the Community of Madrid (Spain) in 2015. The target population was people with CF older than 6 months of age at the beginning of the flu vaccination campaign. The IVC was calculated according to the study variables...
September 7, 2018: Human Vaccines & Immunotherapeutics
Meltem Dinleyici, Merve Iseri Nepesov, Oguz Resat Sipahi, Kursat Bora Carman, Omer Kilic, Ener Cagri Dinleyici
INTRODUCTION: Bacterial meningitis is one of the leading causes of morbidity and mortality among children and adults. Better understanding of the seroepidemiology of meningitis is critical for both the selection and implementation of an effective meningitis vaccine for the national immunization program. Because physicians play a crucial role in the implementation of this vaccine, the aim of this study was to evaluate the attitudes, behaviors, and knowledge of healthcare professionals in Turkey regarding the diagnosis, treatment and prevention of bacterial meningitis, especially pneumococcal and meningococcal meningitis...
September 7, 2018: Human Vaccines & Immunotherapeutics
Juan Jose de la Cruz, Liliana Villanueva-Lizama, Victor Dzul-Huchim, María-Jesus Ramírez-Sierra, Pedro Martinez-Vega, Miguel Rosado-Vallado, Jaime Ortega-Lopez, Claudia Ivonne Flores-Pucheta, Portia Gillespie, Bin Zhan, Maria Elena Bottazzi, Peter J Hotez, Eric Dumonteil
A therapeutic vaccine for human Chagas disease (American trypanosomiasis caused by Trypanosoma cruzi) is under development based on the success of vaccinating mice with DNA constructs expressing the antigens Tc24 and Tc-TSA-1. However, because DNA and nucleic acid vaccines produce less than optimal responses in humans, our strategy relies on administering a recombinant protein-based vaccine, together with adjuvants that promote Th1-type immunity. Here we describe a process for the purification and refolding of recombinant TSA-1 expressed in Escherichia coli...
September 7, 2018: Human Vaccines & Immunotherapeutics
Elisa Peranzoni, Emmanuel Donnadieu
T cell-based immunotherapies have revolutionized the treatment against cancer. But complete and long-lasting efficacy is only observed in a fraction of the patient population. One of the suspected causes is the inability of cytotoxic T cells, endowed with tumor killing ability, to reach their malignant targets. Using dynamic fluorescence imaging to study the dynamic of T cells in tumors from patients with lung cancer, we have recently demonstrated that macrophages trap the T lymphocytes, which are not longer able to contact the tumor cells...
September 7, 2018: Human Vaccines & Immunotherapeutics
Rebecca B Perkins, Marcie Fisher-Borne, Noel T Brewer
No abstract text is available yet for this article.
September 6, 2018: Human Vaccines & Immunotherapeutics
Gili Regev-Yochay, Michal Chowers, Bibiana Chazan, Elisa Gonzalez, Sharon Gray, Zhou Zhang, Michael Pride
BACKGROUND: Community acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide, and is a leading cause of hospitalization in previously healthy individuals without predisposing risk factors or comorbidities. In this study we determined PCV13 serotype distribution in adults aged ≥50 years with radiographically confirmed CAP in Israel. METHODS: Subjects aged ≥50 years were enrolled from one of three hospitals (Emek Medical Center, Meir Medical Center and Sheba Medical Center) from March 2014 to July 2015...
September 6, 2018: Human Vaccines & Immunotherapeutics
Mikhail Petrovich Kostinov, Alexander Petrovich Cherdantsev, Alexei Isaevich Kuselman, Nelli Kimovna Akhmatova, Aristitsa Mikhailovna Kostinova, Elena Viktorovna Deryabina, Evgeniia Olegovna Demina, Anton Mikhailovich Kostinov
Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in the study. Protective antibodies (≥ 1:40) to different influenza strains were registered on day 1 after the birth on the same level as 53% of cases in pairs mothers-infants after immune adjuvant polymeric subunit and subunit vaccines administration...
September 5, 2018: Human Vaccines & Immunotherapeutics
Olatunji O Adetokunboh, Olalekan A Uthman, Charles S Wiysonge
The study determined the prevalence of acute respiratory infections and diarrhoea among sub-Saharan African children. It also examined if there was any significant morbidity benefit conferred by three doses of diphtheria-tetanus-pertussis containing vaccines (DTP3) with respect to maternal HIV status. Data were obtained from the Demographic and Health Survey (DHS) program, United Nations Development Programs, World Bank and Joint United Nations Programme on HIV/AIDS. Pooled odds ratio (OR) and 95% confidence intervals (CI) were calculated for the countries...
September 5, 2018: Human Vaccines & Immunotherapeutics
Thomas F Wierzba
With one-third of nations at risk of cholera, we can expect to experience massive, rapidly disseminated, and prolonged cholera outbreaks such as those recently experienced in Yemen and Haiti. The prevention of cholera outbreaks like these includes the provision of potable water, sanitation, and hygiene (WASH). This approach has been known for generations. However, it will be many years before universal global access to WASH is achieved. While working toward universal WASH, study data has shown that licensed and WHO prequalified cholera vaccines are important tools for cholera prevention...
September 5, 2018: Human Vaccines & Immunotherapeutics
Manish Ramesh, Merhunisa Karagic
Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and better tolerated allergen-derivatives, adjuvants and encapsulated allergens. Diverse routes of allergen immunotherapy - oral, sublingual, epicutanoeus and intralymphatic - are enabling immunotherapy for anaphylactic food allergies and pollen-food allergy syndrome, while improving the tolerability and effectiveness of aeroallergen immunotherapy...
September 5, 2018: Human Vaccines & Immunotherapeutics
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