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Human Vaccines & Immunotherapeutics

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https://www.readbyqxmd.com/read/27905837/long-term-persistence-of-immunity-after-hepatitis-b-vaccination-a-fact-not-a-fancy
#1
Andrea Trevisan
On the basis of an article previously published in the journal regarding immune persistence after hepatitis B vaccination in infancy, I discuss why this persistence is a fact and not a fancy. Immune memory after a primary vaccination series has been widely demonstrated by prompt response to booster doses and the proliferation of T cells secreting IFNγ. In a large cohort of medical students, 79% of subjects were positive for anti-HBs antibodies, and only 1.9% of the subjects had serological evidence of past hepatitis B infection...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905836/invasive-pneumococcal-disease-from-a-tertiary-care-hospital-in-the-post-vaccine-era
#2
Sevgen Tanır Basaranoglu, Eda Karadag Oncel, Kubra Aykac, Yasemin Ozsurekci, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
A breakthrough infection occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in Turkey are previously described. A breakthrough infection is defined as IPD in a child who had received ≥1 PCV-7 or PCV-13 and for which the pneumococcal isolate was a vaccine serotype. During one year period, among six patients with invasive pneumococcal infection, two patients were considered to have a vaccine failure with serotype 19F. Antibiotic resistance results were remarkable; macrolide resistance were observed in all strains except one, and high and intermediate penicillin resistance were determined in two strains...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905835/hemagglutination-inhibiting-antibody-persistence-1-year-after-of-influenza-vaccination-in-korean-children-and-adolescents
#3
Eun-Kyeong Kang, Byung-Wook Eun, Nam-Hee Kim, Yun-Kyung Kim, Jung-Sub Lim, Dong-Ho Kim
This study aimed to assess the one-year immunogenicity of influenza vaccines and the association between immunogenicity at one month and further influenza infections in children aged 6 months to 18 years. Serum hemagglutination inhibition (HI) antibody titers and GMTs were determined for the recommended influenza strains 0, 1, 6, and 12 months post-vaccination. The serological evidence of influenza infections were defined as the increase of HI titer (HI ≥1:40 and 4-fold rise). The seroprotection rates for strains A(H1N1), A(H3N2), and B were 91...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905834/rubella-outbreak-and-outbreak-management-in-a-school-setting-china-2014
#4
Caiyun Chang, Huilai Ma, Wenjia Liang, Pei Hu, Xianghuan Mo, Zhijie An, Huizhen Zheng
BACKGROUND: An active response to a rubella outbreak may interrupt disease transmission, and outbreak response immunization (ORI) can increase immunity among persons who might otherwise not be protected. On March 17, 2014, a rubella outbreak was reported in a middle school in Guangzhou city, China. We conducted an investigation to assess impact of a policy of exclusion of cases from school and of ORI. METHODS: Active surveillance was used to find cases of rubella...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905833/non-conventional-expression-systems-for-the-production-of-vaccine-proteins-and-immunotherapeutic-molecules
#5
Isabelle Legastelois, Sophie Buffin, Isabelle Peubez, Charlotte Mignon, Régis Sodoyer, Bettina Werle
The increasing demand for recombinant vaccine antigens or immunotherapeutic molecules calls into question the universality of current protein expression systems. Vaccine production can require relatively low amounts of expressed materials, but represents an extremely diverse category consisting of different target antigens with marked structural differences. In contrast, monoclonal antibodies, by definition share key molecular characteristics and require a production system capable of very large outputs, which drives the quest for highly efficient and cost-effective systems...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905832/dengue-vaccine-acceptance-and-willingness-to-pay
#6
Harapan Harapan, Jonny K Fajar, Ulrich Kuch
The introduction of new vaccines is accompanied by a variety of challenges. Among these, very important ones concern the questions whether the public is willing to accept and willing to purchase the vaccine. Here we discuss factors associated with these questions in the context of vaccines that are becoming available against dengue virus infection. We reviewed published studies available from PubMed and Embase, conducting a meta-analysis when possible and narrative review when the data did not qualify for meta-analysis...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905821/effects-of-hepatitis-b-vaccine-boosters-on-anti-hbs-negative-children-after-primary-immunization
#7
Shunshun Lu, Jingjing Ren, Qian Li, Zhenggang Jiang, Yongdi Chen, Kaijin Xu, Bing Ruan, Shigui Yang, Tiansheng Xie, Linna Yang, Jing Li, Jun Yao
This study was aimed at evaluating the changes of hepatitis B surface antibody (anti-HBs) titer after booster vaccinations in 5-15-year-old children with negative antibodies (< 10 mIU/mL). 225 subjects (mean age, 9.28 ± 2.95 years) included in the study consisted of 123 males and 102 females, with a complete hepatitis B vaccination during infancy. The participants were divided into three groups according to their pre-booster anti-HBs level: Group I, < 0.1 mIU/mL; Group II, 0.1 to < 1.0 mIU/mL; Group III, 1...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905819/mothers-preferences-regarding-new-combination-vaccines-for-their-children-in-japan-2014
#8
Aiko Shono, Masahide Kondo
A number of new vaccines to prevent childhood diseases have been introduced globally over the last few decades. Only four combination vaccines are currently available in Japan, DTaP/sIPV, DTaP, DT, and MR, leading to complex infant vaccine scheduling. This study aims to investigate mothers' preferences with respect to combination vaccines for their children, should new combination vaccines become available that have not yet been launched in Japan or that will be developed in the future. We conducted a web-based, cross-sectional survey of 1,243 mothers who had at least one child between 2 months and 3 years of age...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27901642/a-generic-rna-pulsed-dc-based-approach-for-developing-therapeutic-intervention-against-nasopharyngeal-carcinoma
#9
Rajeev K Tyagi, Rajesh Parmar, Naisargee Patel
The recurrent nasopharyngeal carcinoma of head-and-neck cancers pathology showed unique symptoms and clinical characteristics. The complexity of pathology poses challenges for developing therapeutic interventional approaches against nasopharyngeal carcinoma (NPC). The conventional treatment regimens offer limited local control and survival, which, leads to adverse delayed complications. Our study present a generic monocyte derived dendritic cell (MoDC) vaccine strategy for NPC in which RNA is used as a source of tumor-associated antigens (TAAgs)...
November 30, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27901633/acute-flaccid-paralysis-laboratorial-surveillance-in-a-polio-free-country-brazil-2005-2014
#10
Ivanildo P Sousa, Fernanda M Burlandy, Silas S Oliveira, Amanda M Nunes, Cristiane Sousa, Elaine M da Silva, Jaqueline G A Souza, Valdemar A de Paula, Ivone C M Oliveira, Fernando Neto Tavares, Eliane V da Costa, Edson E da Silva
The last case of paralytic poliomyelitis caused by wild poliovirus in Brazil occurred in 1989. The interruption of the indigenous poliovirus transmission was obtained through mass immunization campaigns to eligible children and an active epidemiological and laboratorial surveillance of all cases of acute flaccid paralysis (AFP) among children under fifteen years of age. This paper describes and evaluates the performance of the AFP surveillance system in different geographic areas of Brazil between 2005 and 2014, using indicators recommended by WHO...
November 30, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27880083/how-do-parents-and-pediatricians-arrive-at-the-decision-to-immunize-their-children-in-the-private-sector-insights-from-a-qualitative-study-on-rotavirus-vaccination-across-select-indian-cities
#11
Mathew Sunil George, Preeti Negandhi, Habib Hassan Farooqui, Anjali Sharma, Sanjay Zodpey
Key debates on improving vaccination coverage tend to focus on factors that affect uptake in the public health system while ignoring the private sector that plays an important role in providing health services in any low or middle-income country setting. Using in-depth interviews, we explored factors that influenced the decision of parents as well as pediatricians working in the private sector across 8 Indian cities on whether their children should be vaccinated with a particular vaccine Pediatricians and their relationship with parents was an important factor that influenced the decision on whether parents vaccinated their children with a particular vaccine or not...
November 23, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27874311/long-term-persistence-in-protection-and-response-to-a-hepatitis-b-vaccine-booster-among-adolescents-immunized-in-infancy-in-the-western-region-of-china
#12
Zhen-Zi Wang, Yu-Hua Gao, Wei Lu, Cun-Duo Jin, Ying Zeng, Ling Yan, Feng Ding, Tong Li, Xue-En Liu, Hui Zhuang
OBJECTIVES: To evaluate the persistence of protection from hepatitis B (HB) vaccination among adolescents immunized with a primary series of HB vaccine as infants, and the immune response to booster doses. METHODS: Healthy adolescents aged 15-17 years vaccinated with HB vaccine only at birth were enrolled. Baseline serum hepatitis B surface antigen (HBsAg), antibody against hepatitis B surface antigen (anti-HBs) and antibody against hepatitis B core antigen (anti-HBc) were detected by Enzyme-Linked Immunosorbent Assay (ELISA) and anti-HBs level was measured using Chemiluminescent Microparticle Immunoassay (CMIA)...
November 22, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27870598/potential-applications-of-nanoparticles-in-cancer-immunotherapy
#13
Yimei Jia, Abdelwahab Omri, Lakshmi Krishnan, Michael J McCluskie
In recent years considerable progress has been made in the field of cancer immunotherapy whereby treatments that modulate the body's own immune system are used to combat cancer. This has the potential to not only elicit strong anti-cancer immune responses which can break pre-existing tolerance and help promote tumor regression, but could also induce immunological memory which may help prevent tumor recurrence. In order to ensure effective delivery of immunotherapeutic agents, such as vaccines, checkpoint inhibitors, chemotherapeutic agents and nucleic acids, a safe and effective delivery system is often required...
November 21, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27870594/immune-design
#14
Jan Ter Meulen, Stephen R Brady
No abstract text is available yet for this article.
November 21, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27870591/human-transcriptome-response-to-immunization-with-live-attenuated-venezuelan-equine-encephalitis-virus-vaccine-tc-83-analysis-of-whole-blood
#15
Rebecca A Erwin-Cohen, Aimee I Porter, Phillip R Pittman, Cynthia A Rossi, Luis DaSilva
Venezuelan equine encephalitis virus (VEEV) is an important human and animal alphavirus pathogen transmitted by mosquitoes. The virus is endemic in Central and South America, but has also caused equine outbreaks in southwestern areas of the United States. In an effort to better understand the molecular mechanisms of the development of immunity to this important pathogen, we performed transcriptional analysis from whole, unfractionated human blood of patients who had been immunized with the live-attenuated vaccine strain of VEEV, TC-83...
November 21, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27858509/review-of-seasonal-influenza-in-canada-burden-of-disease-and-the-cost-effectiveness-of-quadrivalent-inactivated-influenza-vaccines
#16
Edward W Thommes, Morgan Kruse, Michele Kohli, Rohita Sharma, Stephen G Noorduyn
In the 2015/16 influenza season, the Canadian National Advisory Committee on Immunization (NACI) recommended vaccination with quadrivalent inactivated influenza vaccine (QIV) for infants aged 6-23 months and trivalent inactivated influenza vaccines (TIVs) or QIVs in adults. The objective of this review (GSK study identifier: HO-13-14054) is to examine the epidemiology and disease burden of influenza in Canada and the economic benefits of vaccination. To inform this review, we performed a systematic literature search of relevant Canadian literature and National surveillance data...
November 18, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27858500/undervaccination-with-diphtheria-tetanus-and-pertussis-vaccine-national-trends-and-association-with-pertussis-risk-in-young-children
#17
Wan-Ting Huang, Hui-Chen Lin, Chin-Hui Yang
BACKGROUND: The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. METHODS: In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression...
November 18, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27846370/dissolving-microneedles-for-dna-vaccination-improving-functionality-via-polymer-characterisation-and-rala-complexation
#18
Grace Cole, Joanne McCaffrey, Ahlam A Ali, John W McBride, Cian M McCrudden, Eva M Vincente-Perez, Ryan F Donnelly, Helen O McCarthy
DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from degradation and improve transfection efficiencies in vivo. Recently, microneedles have been described as a novel physical delivery technology to enhance DNA vaccine immunogenicity. Of these devices, dissolvable microneedles promise a safe, pain-free delivery system which may simultaneously improve DNA stability within a solid matrix and increase DNA delivery compared to solid arrays...
November 15, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27841725/safety-of-the-human-papillomavirus-hpv-16-18-as04-adjuvanted-vaccine-in-adolescents-aged-12-15%C3%A2-years-interim-analysis-of-a-large-community-randomized-controlled-trial
#19
Matti Lehtinen, Tiina Eriksson, Dan Apter, Mari Hokkanen, Kari Natunen, Jorma Paavonen, Eero Pukkala, Maria-Genalin Angelo, Julia Zima, Marie-Pierre David, Sanjoy Datta, Dan Bi, Frank Struyf, Gary Dubin
This community-randomized controlled trial was initiated to assess the overall and herd effects of two different human papillomavirus (HPV) immunization strategies in over 80,000 girls and boys aged 12-15 years in 33 communities in Finland (ClinicalTrials.gov NCT00534638). Overall, 14,838 adolescents received HPV-16/18 vaccine (2,440 boys and 12,398 girls) and 17,338 received hepatitis-B virus (HBV) vaccine (9,221 boys and 8,117 girls). In an interim analysis, vaccine safety was assessed by active monitoring and surveillance via health registry linkage...
November 14, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27835525/assessing-the-risk-of-intussusception-and-rotavirus-vaccine-safety-in-canada
#20
Steven Hawken, Robin Ducharme, Laura C Rosella, Eric I Benchimol, Joanne M Langley, Kumanan Wilson, Natasha S Crowcroft, Scott A Halperin, Shalina Desai, Monika Naus, Carolyn J Sanford, Salah M Mahmud, Shelley L Deeks
BACKGROUND: Intussusception has been identified as a rare adverse event following rotavirus immunization. We sought to determine the incidence of intussusception among infants in Canada both before and after introduction of rotavirus immunization programs. METHODS: We used Canadian Institute for Health Information (CIHI) Discharge Abstract Database (DAD) to identify infants under 1 year of age who were admitted to a Canadian hospital, which the exception of Quebec, which does not submit data to CIHI, with a diagnosis of intussusception (ICD-10 code K56...
November 11, 2016: Human Vaccines & Immunotherapeutics
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