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Annals of Laboratory Medicine

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https://www.readbyqxmd.com/read/28029011/clinical-pharmacogenetic-testing-and-application-laboratory-medicine-clinical-practice-guidelines
#1
Sollip Kim, Yeo Min Yun, Hyo Jin Chae, Hyun Jung Cho, Misuk Ji, In Suk Kim, Kyung A Wee, Woochang Lee, Sang Hoon Song, Hye In Woo, Soo Youn Lee, Sail Chun
Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinions for the clinical pharmacogenetic testing covered by public medical insurance in Korea. This document aims to improve the utility of pharmacogenetic testing in routine clinical settings...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029010/concomitant-aid-expression-and-bcl7a-loss-associates-with-accelerated-phase-progression-and-imatinib-resistance-in-chronic-myeloid-leukemia
#2
LETTER
Nae Yu, Saeam Shin, Jong Rak Choi, Yoonjung Kim, Kyung A Lee
No abstract text is available yet for this article.
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029009/susceptibility-of-ceftolozane-tazobactam-and-ceftazidime-avibactam-against-a-collection-of-%C3%AE-lactam-resistant-gram-negative-bacteria
#3
LETTER
Mark D Gonzalez, Allison R McMullen, Meghan A Wallace, Matthew P Crotty, David J Ritchie, Carey Ann D Burnham
No abstract text is available yet for this article.
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029008/colistin-resistance-in-escherichia-coli-isolates-from-patients-with-bloodstream-infection-in-korea
#4
LETTER
Young Ah Kim, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee
No abstract text is available yet for this article.
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029007/thyroxine-t4-autoantibody-interference-of-free-t4-concentration-measurement-in-a-patient-with-hashimoto-s-thyroiditis
#5
LETTER
Mi Na Lee, Soo Youn Lee, Kyu Yeon Hur, Hyung Doo Park
No abstract text is available yet for this article.
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029006/a-case-of-therapy-related-acute-leukemia-with-mixed-phenotype-with-bcr-abl1-after-treatment-of-diffuse-large-b-cell-lymphoma
#6
LETTER
Dahae Yang, Sung Ran Cho, Seri Jung, Woonhyoung Lee, Hyun Yong Hwang, Ho Seop Lee, Yang Soo Kim, Jong Rak Choi, Mi Hyang Kim
No abstract text is available yet for this article.
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029005/familial-hemophagocytic-lymphohistiocytosis-type-2-in-a-korean-infant-with-compound-heterozygous-prf1-defects-involving-a-prf1-mutation-c-1091t-g
#7
LETTER
Min Sun Kim, Young Uk Cho, Seongsoo Jang, Eul Ju Seo, Ho Joon Im, Chan Jeoung Park
No abstract text is available yet for this article.
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029004/differences-in-hematological-and-clinical-features-between-essential-thrombocythemia-cases-with-jak2-or-calr-mutations
#8
LETTER
Yoko Kubuki, Kotaro Shide, Takuro Kameda, Takumi Yamaji, Masaaki Sekine, Ayako Kamiunten, Keiichi Akizuki, Haruko Shimoda, Yuki Tahira, Kenichi Nakamura, Hiroo Abe, Tadashi Miike, Hisayoshi Iwakiri, Yoshihiro Tahara, Mitsue Sueta, Kanna Hashimoto, Shojiro Yamamoto, Satoru Hasuike, Tomonori Hidaka, Kenji Nagata, Akira Kitanaka, Kazuya Shimoda
No abstract text is available yet for this article.
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029003/effect-of-vitamin-d-status-on-von-willebrand-factor-and-adamts13-in-diabetic-patients-on-chronic-hemodialysis
#9
Keren Cohen-Hagai, Gloria Rashid, Yael Einbinder, Meital Ohana, Sydney Benchetrit, Tali Zitman-Gal
Von Willebrand factor (vWF) is a glycoprotein with a crucial role in the formation of platelet thrombi, and ADAMTS13 is the main enzyme responsible for vWF cleavage. Both are important in the relationship between diabetic nephropathy, hypercoagulability, and cardiovascular disease. This study evaluated a potential relationship between vitamin D (vitD) levels, vWF, ADAMTS13 activity, and inflammation in diabetic patients on chronic hemodialysis (HD). Blood samples from 52 diabetic patients on chronic HD were obtained to determine vitD levels, vWF, and ADAMTS13 activity, and inflammatory markers...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029002/dengue-virus-serotypes-circulating-in-khyber-pakhtunkhwa-province-pakistan-2013-2015
#10
Muhammad Suleman, Rani Faryal, Muhammad Masroor Alam, Salmaan Sharif, Shahzad Shaukat, Uzma Bashir Aamir, Adnan Khurshid, Mehar Angez, Massab Umair, Mian Muhammad Sufian, Yasir Arshad, Syed Sohail Zahoor Zaidi
From 2013 to 2015, the National Institute of Health, Pakistan, received 1,270 blood samples of suspected dengue cases reported from inpatient and outpatient departments of various hospitals in Khyber Pakhtunkhwa (KPK) province. In this study, we determined the circulating dengue virus (DENV) serotypes using real-time reverse transcriptase (RT)-PCR to understand the serotype-based epidemiology of DENV. All four serotypes (DENV-1 [6%], DENV-2 [33%], DENV-3 [47%], and DENV-4 [0.1%]) were found circulating during the study period...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029001/performance-of-the-real-q-ebv-quantification-kit-for-epstein-barr-virus-dna-quantification-in-whole-blood
#11
Hee Jae Huh, Jong Eun Park, Ji Youn Kim, Sun Ae Yun, Myoung Keun Lee, Nam Yong Lee, Jong Won Kim, Chang Seok Ki
There has been increasing interest in standardized and quantitative Epstein-Barr virus (EBV) DNA testing for the management of EBV disease. We evaluated the performance of the Real-Q EBV Quantification Kit (BioSewoom, Korea) in whole blood (WB). Nucleic acid extraction and real-time PCR were performed by using the MagNA Pure 96 (Roche Diagnostics, Germany) and 7500 Fast real-time PCR system (Applied Biosystems, USA), respectively. Assay sensitivity, linearity, and conversion factor were determined by using the World Health Organization international standard diluted in EBV-negative WB...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28029000/comparison-between-soluble-st2-and-high-sensitivity-troponin-i-in-predicting-short-term-mortality-for-patients-presenting-to-the-emergency-department-with-chest-pain
#12
Rossella Marino, Laura Magrini, Francesca Orsini, Veronica Russo, Patrizia Cardelli, Gerardo Salerno, Mina Hur, Salvatore Di Somma
BACKGROUND: High-sensitivity cardiac troponin I (hs-cTnI) and the soluble isoform of suppression of tumorigenicity 2 (sST2) are useful prognostic biomarkers in acute coronary syndrome (ACS). The aim of this study was to test the short term prognostic value of sST2 compared with hs-cTnI in patients with chest pain. METHODS: Assays for hs-cTnI and sST2 were performed in 157 patients admitted to the Emergency Department (ED) for chest pain at arrival. In-hospital and 30-day follow-up mortalities were assessed...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28028999/automated-nucleic-acid-extraction-systems-for-detecting-cytomegalovirus-and-epstein-barr-virus-using-real-time-pcr-a-comparison-study-between-the-qiasymphony-rgq-and-qiacube-systems
#13
Hanah Kim, Mina Hur, Ji Young Kim, Hee Won Moon, Yeo Min Yun, Hyun Chan Cho
BACKGROUND: Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are increasingly important in immunocompromised patients. Nucleic acid extraction methods could affect the results of viral nucleic acid amplification tests. We compared two automated nucleic acid extraction systems for detecting CMV and EBV using real-time PCR assays. METHODS: One hundred and fifty-three whole blood (WB) samples were tested for CMV detection, and 117 WB samples were tested for EBV detection...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28028998/long-term-quality-control-program-plan-for-cord-blood-banks-in-korea-a-pilot-study-for-cryopreservation-stability
#14
Soo Hyun Seo, Sue Shin, Eun Youn Roh, Eun Young Song, Sohee Oh, Byoung Jae Kim, Jong Hyun Yoon
BACKGROUND: Maintaining the quality of cryopreserved cord blood is crucial. In this pilot study, we describe the results of the internal quality control program for a cord blood bank thus far. METHODS: Donated cord blood units unsuitable for transplantation were selected for internal quality control once a month. One unit of cord blood, aliquoted into 21 capillaries, was cryopreserved and thawed annually to analyze the total nucleated cell count, CD34⁺ cell count, cell viability test, and colony-forming units assay...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28028997/comparative-analysis-of-clinical-samples-showing-weak-serum-reaction-on-autovue-system-causing-abo-blood-typing-discrepancies
#15
Su Yeon Jo, Ju Mi Lee, Hye Lim Kim, Kyeong Hwa Sin, Hyeon Ji Lee, Chulhun Ludgerus Chang, Hyung Hoi Kim
BACKGROUND: ABO blood typing in pre-transfusion testing is a major component of the high workload in blood banks that therefore requires automation. We often experienced discrepant results from an automated system, especially weak serum reactions. We evaluated the discrepant results by the reference manual method to confirm ABO blood typing. METHODS: In total, 13,113 blood samples were tested with the AutoVue system; all samples were run in parallel with the reference manual method according to the laboratory protocol...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28028996/genetic-profiles-of-korean-patients-with-glucose-6-phosphate-dehydrogenase-deficiency
#16
Jaewoong Lee, Joonhong Park, Hayoung Choi, Jiyeon Kim, Ahlm Kwon, Woori Jang, Hyojin Chae, Myungshin Kim, Yonggoo Kim, Jae Wook Lee, Nack Gyun Chung, Bin Cho
BACKGROUND: We describe the genetic profiles of Korean patients with glucose-6-phosphate dehydrogenase (G6PD) deficiencies and the effects of G6PD mutations on protein stability and enzyme activity on the basis of in silico analysis. METHODS: In parallel with a genetic analysis, the pathogenicity of G6PD mutations detected in Korean patients was predicted in silico. The simulated effects of G6PD mutations were compared to the WHO classes based on G6PD enzyme activity...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28028995/recommendations-for-optimizing-tuberculosis-treatment-therapeutic-drug-monitoring-pharmacogenetics-and-nutritional-status-considerations
#17
REVIEW
Rihwa Choi, Byeong Ho Jeong, Won Jung Koh, Soo Youn Lee
Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the use of multiple drugs over long periods of time can cause frequent adverse drug reactions. In addition, some patients with drug-susceptible tuberculosis do not respond adequately to treatment and develop treatment failure and drug resistance. Response to tuberculosis treatment could be affected by multiple factors associated with the host-pathogen interaction including genetic factors and the nutritional status of the host...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27834077/erratum-current-pathological-and-laboratory-considerations-in-the-diagnosis-of-disseminated-intravascular-coagulation
#18
(no author information available yet)
This corrects the article on p. 505 in vol. 36, PMID: 27578502.
January 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27834076/acromicric-dysplasia-caused-by-a-novel-heterozygous-mutation-of-fbn1-and-effects-of-growth-hormone-treatment
#19
LETTER
Hyung Suk Jin, Ho Young Song, Sung Yoon Cho, Chang Seok Ki, Song Hyun Yang, Ok Hwa Kim, Su Jin Kim
No abstract text is available yet for this article.
January 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27834075/de-novo-san-luis-valley-syndrome-like-der-8-chromosome-with-a-concomitant-dup-8p22-in-a-mexican-girl
#20
LETTER
Alma Laura Sánchez-Casillas, Horacio Rivera, Anna Gabriela Castro-Martínez, José Elías García-Ortiz, Carlos Córdova-Fletes, Paul Mendoza-Pérez
No abstract text is available yet for this article.
January 2017: Annals of Laboratory Medicine
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