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Allergy & Rhinology

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https://www.readbyqxmd.com/read/28583236/complete-response-of-skull-base-inverted-papilloma-to-chemotherapy-case-report
#1
Edward C Kuan, John W Frederick, Miguel F Palma Diaz, Dean W Lim, Jeffrey D Suh
BACKGROUND: Inverted papilloma (IP) is the most common benign sinonasal neoplasm. Endoscopic techniques, improved understanding of pathophysiology, and novel surgical approaches have allowed rhinologists to treat IPs more effectively, with surgery being the mainstay of therapy. Frontal sinus IP poses a challenge for surgical therapy due to complex anatomy and potentially difficult surgical access. OBJECTIVES: We reported a unique case of a massive frontal sinus IP that presented with intracranial and orbital extension, with near resolution after chemotherapy...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583235/type-1-kounis-syndrome-in-a-patient-with-idiopathic-anaphylaxis
#2
Monica Sandhu, Jason Casselman, Brian Peppers, Haig Tcheurekdjian, Robert W Hostoffer
Anaphylactic insults that cause cardiovascular signs and symptoms have been defined as Kounis syndrome, which has been associated with specific triggered anaphylactic reactions. Kounis syndrome has not been described in patients with no evidence of coronary artery disease (type I Kounis) in a scenario of idiopathic anaphylaxis. We reported a case of a 65-year-old white woman with no evidence of coronary artery disease who experienced two myocardial infarctions on separate occasions attributable to idiopathic anaphylaxis...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583234/bilateral-silent-sinus-syndrome-a-rare-case-and-review-of-literature
#3
Michal Trope, Joseph S Schwartz, Bobby A Tajudeen, David W Kennedy
OBJECTIVE: In this report, we presented a rare case of bilateral silent sinus syndrome (SSS) in an otherwise healthy 57-year-old man treated with functional endoscopic sinus surgery (FESS). A systematic review of the literature regarding bilateral SSS was performed. CASE REPORT: A 57-year-old man with well-controlled allergic rhinitis in the absence of previous surgery or trauma presented with bilateral SSS, which was successfully managed with bilateral FESS. METHODS: A medical literature data base search of the terms "silent sinus syndrome" "maxillary atelectasis," "imploding antrum syndrome," and "bilateral silent sinus syndrome" was performed...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583233/myxofibrosarcoma-of-the-maxillary-sinus
#4
Anni Wong, Richard Chan Woo Park, Neena M Mirani, Jean Anderson Eloy
BACKGROUND: Myxofibrosarcoma (MFS) is a common sarcoma in the extremities of older individuals but is extremely uncommon in the head and neck region. Diagnosis may be challenging but is critical to the management of the patient. We discuss the radiographic and histopathologic characteristics of this destructive tumor. The distinguishing features of MFS and its differential diagnosis are reviewed to familiarize the managing otolaryngologist with this rare entity. METHODS: A 61-year-old woman presents with a 6-week history of severe left facial pain and left eye pain...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583232/effect-of-topical-beclomethasone-on-inflammatory-markers-in-adults-with-eosinophilic-esophagitis-a-pilot-study
#5
Neeti Bhardwaj, Faoud Ishmael, Erik Lehman, Deborah Bethards, Francesca Ruggiero, Gisoo Ghaffari
BACKGROUND: Topical corticosteroids have proven efficacy in the treatment of eosinophilic esophagitis (EoE) and are considered the cornerstone of therapy. OBJECTIVE: To evaluate the effect of topical beclomethasone dipropionate (BDP) therapy on clinical outcomes, esophageal eosinophilia, and other markers of inflammation in patients with EoE. METHODS: Nine subjects with a biopsy-proven diagnosis of EoE were enrolled. In a cross-over design, the subjects were randomly assigned to a sequence of BDP and placebo...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583231/utility-of-intraoperative-flexible-endoscopy-in-frontal-sinus-surgery
#6
Eric T Carniol, Alejandro Vázquez, Tapan D Patel, James K Liu, Jean Anderson Eloy
BACKGROUND: Surgical management of the frontal sinus can be challenging. Extensive frontal sinus pneumatization may form a far lateral or supraorbital recess that can be difficult to reach by conventional endoscopic surgical techniques, requiring extended approaches such as the Draf III (or endoscopic modified Lothrop) procedure. Rigid endoscopes may not allow visualization of these lateral limits to ensure full evacuation of the disease process. METHODS: Here we describe the utility of intraoperative flexible endoscopy in two patients with far lateral frontal sinus disease...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583230/differential-expression-of-micrornas-and-their-possible-roles-in-patients-with-chronic-idiopathic-urticaria-and-active-hives
#7
Ching-Kow E Lin, John S Kaptein, Javed Sheikh
BACKGROUND: Chronic idiopathic urticaria (CIU) is a complicated skin disease with unknown pathophysiology. MicroRNAs (miRNA) have been shown to be active in cellular regulation. The goal of this pilot study was to examine whether miRNAs may be involved in the regulation of CIU or as biomarkers for CIU. METHODS: Four groups of three patients each were selected: patients with either active hives or no hives and with positive or negative chronic urticaria (CU) index results...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583229/landmarks-for-rapid-localization-of-the-sphenopalatine-foramen-a-radiographic-morphometric-analysis
#8
Anne K Maxwell, Henry P Barham, Anne E Getz, Todd T Kingdom, Vijay R Ramakrishnan
BACKGROUND: Transnasal endoscopic sphenopalatine artery ligation is becoming the procedure of choice for surgical management of intractable posterior epistaxis. Landmarks for localization of the sphenopalatine foramen can assist in rapid surgical exposure of the sphenopalatine artery. OBJECTIVE: This study examined distances from easily identified endoscopic surgical landmarks to the sphenopalatine foramen. METHODS: By using computed tomography of the sinus to study radiologic anatomy in 50 adults, distances were measured between five simple endoscopic landmarks and the sphenopalatine foramen...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583228/diagnosing-environmental-allergies-comparison-of-skin-prick-intradermal-and-serum-specific-immunoglobulin-e-testing
#9
Denisa Ferastraoaru, Maria Shtessel, Elizabeth Lobell, Golda Hudes, David Rosenstreich, Gabriele de Vos
BACKGROUND: Allergists commonly perform intradermal skin testing (IDST) after negative skin-prick testing (SPT) to comprehensively diagnose environmental allergic sensitization. However, with the availability of modern methods to detect serum-specific immunoglobulin E (ssIgE), it is unclear if ssIgE testing could substitute for IDST. OBJECTIVE: To determine the efficacy of ssIgE testing and IDST when added to SPT in diagnosing environmental allergic sensitizations...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28583227/differential-diagnosis-and-proper-treatment-of-acute-rhinosinusitis-guidance-based-on-historical-data-analysis
#10
Gregor Cevc
BACKGROUND: The time course of rhinovirus positive and negative rhinosinusitis has not been quantified yet, which aggravates proper selection and justification of the optimum treatment for this illness. Such quantitative information would facilitate an early and proper identification of the disease and its differentiation from acute bacterial rhinosinusitis, and could diminish harmful overuse of antibiotics, arguably driven by patients' want for attention and the treating physicians' inability to offer an adequate verbal comfort in its stead...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381327/autoimmune-related-nasal-septum-perforation-a-case-report-and-systematic-review
#11
Lohitha Guntupalli, Kunjan Patel, Farhoud Faraji, Joseph D Brunworth
BACKGROUND: Inflammatory injury of nasal respiratory mucosa is a common feature of multisystem autoimmune disease. Certain autoimmune disorders are associated with nasal septum perforation (NSP). We performed a systematic review of the literature to better understand the association of NSP with specific autoimmune disorders. This is a case report of a 29-year-old woman with a history of arthralgia, autoreactive antibody titers, platelet dysfunction, and NSP. The constellation of symptoms and potential familial involvement indicated that the NSP in this patient was an early sign of an autoimmune disorder, an unknown autoimmune disorder, or a known disease with incomplete penetrance...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381326/intrasinus-penetration-of-a-silastic-malar-implant-which-resulted-in-chronic-sinusitis-a-case-report-and-literature-review
#12
Luke Y Kim, Joseph S Schwartz, Bobby A Tajudeen, Nithin D Adappa, James N Palmer
BACKGROUND: Malar augmentation is a common cosmetic procedure utilizing silastic materials. We describe an uncommon complication of a silastic implant eroding into the anterior maxillary sinus wall resulting in chronic rhinosinusitis (CRS). METHODS: A literature review is presented describing the presentation, surgical management and outcome of this uncommon adverse event. RESULTS: An 80 year old female with a history of bilateral cosmetic malar implants placed approximately 25 years ago presented to our office with a 4-5 month history of left-sided symptoms consistent with chronic sinusitis, and was found to have intrasinus penetration of her left malar implant...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381325/ossifying-fibroma-of-the-maxilla-and-sinonasal-tract-case-series
#13
Jack J Liu, Lester D R Thompson, Agnieszka M Janisiewicz, Terry Y Shibuya, David B Keschner, Rohit Garg, Jivianne T Lee
BACKGROUND: Head and neck ossifying fibroma (OF) is a rare, benign, locally aggressive, fibro-osseous tumor. The mandible is the most common site of involvement, followed by the maxilla, and, less frequently, the sinonasal cavities, orbit, skull base, and calvarium. In this study, we aimed to expand our understanding of this entity by presenting a case series of OF that involved the maxilla and sinonasal tract. METHODS: A multicenter retrospective review was performed on all the patients with a diagnosis of OF from 2004 to 2013...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381324/quality-of-life-improvement-after-endoscopic-sinus-surgery-in-patients-with-obstructive-sleep-apnea
#14
Bobby A Tajudeen, Steven G Brooks, Carol H Yan, Edward C Kuan, Joseph S Schwartz, Jeffrey D Suh, James N Palmer, Nithin D Adappa
BACKGROUND: There is preliminary evidence that patients with chronic rhinosinusitis (CRS) and comorbid obstructive sleep apnea (OSA) have reduced quality-of-life (QOL) improvements after functional endoscopic sinus surgery (FESS) compared with patients without OSA. The effect of OSA severity on QOL improvement after FESS is unknown. OBJECTIVES: To better characterize the QOL improvement after FESS for patients with comorbid OSA and to assess whether QOL improvement is dependent on OSA severity...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381323/flexible-microsensor-technology-for-real-time-navigation-tracking-in-balloon-sinus-ostial-dilation
#15
Kent Lam, Jo-Lawrence Bigcas, Amber Luong, William Yao, Martin J Citardi
BACKGROUND: Microsensor navigation has the potential to aid balloon sinus ostial dilation by providing real-time tracking of balloon devices within the complex anatomy of the sinonasal cavities. OBJECTIVE: This feasibility study evaluated the incorporation of a new microsensor technology into a flexible guidewire for use with current instruments in balloon sinus ostial dilation. METHODS: A retrospective study was conducted to include seven men and one woman (age range, 33-68 years), who underwent balloon sinus ostial dilation with flexible microsensor navigation in the operating room setting...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381322/efficacy-and-safety-of-an-intravenous-c1-inhibitor-concentrate-for-long-term-prophylaxis-in-hereditary-angioedema
#16
Timothy Craig, Ralph Shapiro, Arthur Vegh, James W Baker, Jonathan A Bernstein, Paula Busse, Markus Magerl, Inmaculada Martinez-Saguer, Marc A Riedl, William Lumry, Debora Williams-Herman, Jonathan Edelman, Henrike Feuersenger, Thomas Machnig, Mikhail Rojavin
BACKGROUND: The plasma-derived, pasteurized, nanofiltered C1-inhibitor concentrate (pnfC1-INH) is approved in the United States as an intravenous (IV) on-demand treatment for hereditary angioedema (HAE) attacks, and, in Europe, as on demand and short-term prophylaxis. OBJECTIVE: This analysis evaluated Berinert Patient Registry data regarding IV pnfC1-INH used as long-term prophylaxis (LTP). METHODS: The international registry (2010-2014) collected prospective and retrospective usage, dosing, and safety data on individuals who used pnfC1-INH for any reason...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381321/the-impact-of-total-immunoglobulin-e-levels-on-outcomes-of-maximal-medical-therapy-for-chronic-rhinosinusitis
#17
Ana M Lemos-Rodriguez, Zainab Farzal, Satyan B Sreenath, Brian D Thorp, Brent A Senior, Adam M Zanation, Charles S Ebert
INTRODUCTION: The goal of this project was to evaluate the impact of immunoglobulin E (IgE) levels on outcomes in patients with chronic rhinosinusitis (CRS) who received maximal medical therapy (MMT). STUDY DESIGN: Prospective cohort study. METHODS: Thirty-eight patients who underwent MMT for CRS were assigned to three different cohorts based on their IgE levels: low IgE (<25 IU), moderate (>25 to <149 IU), and high (≥150 IU). The primary outcome evaluated was MMT failure with a surgical recommendation within each IgE cohort...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28381320/allergen-specific-immunoglobulin-e-and-allergic-rhinitis-severity
#18
Angelo G Corsico, Mara De Amici, Vanessa Ronzoni, Vania Giunta, Maria Chiara Mennitti, Arianna Viscardi, Gian Luigi Marseglia, Giorgio Ciprandi
BACKGROUND: Allergic rhinitis (AR) is a common disorder. The diagnosis is based on the concordance between allergy sensitization and history. Serum allergen specific immunoglobulin E (sIgE) assessment allows characterization of the relevant sensitizing allergens. Presently, Allergic Rhinitis and its Impact on Asthma (ARIA) classification subdivides AR based on symptoms severity and duration. However, the relationship between sIgE levels and symptom severity is still a matter of debate...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/27466026/role-of-antioxidants-on-the-clinical-outcome-of-patients-with-perennial-allergic-rhinitis
#19
B Chauhan, M Gupta, K Chauhan
BACKGROUND: Antioxidants have a preventive or therapeutic role in oxygen free radical-mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis. METHODS: Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B (n = 31) received FF with antioxidants for 6 weeks...
July 26, 2016: Allergy & Rhinology
https://www.readbyqxmd.com/read/28683253/association-between-vasomotor-rhinitis-and-irritable-bowel-syndrome
#20
Maria Lauriello, Alberto Eibenstein, Anna Maria Angelone, Marina Pasqua, Cinzia Tucci, Carla Di Giacomo, Arnaldo Salerno, Giuseppe Frieri, Marco Fusetti
BACKGROUND: Vasomotor rhinitis (VMR) and irritable bowel syndrome (IBS) are two of the most widespread pathologies in industrialized countries, and they have a substantial impact on health-related quality of life. OBJECTIVE: To investigate the relationship between VMR and IBS to provide evidence to classify VMR and IBS as a sole disorder. METHODS: The study included 150 patients from San Salvatore Hospital, L'Aquila: 50 with VMR, 50 with IBS, and 50 healthy volunteers...
January 1, 2016: Allergy & Rhinology
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