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Allergy & Rhinology

Maxwell Y Li, Jason Kolfenbach, Alan Schocket
No abstract text is available yet for this article.
January 2018: Allergy & Rhinology
Ahmad Rezaeian, Sanaz Amoushahi Khouzani
Background: Chronic rhinosinusitis (CRS) is a common inflammatory disease of nasal and paranasal sinuses, with many treatment methods available for the management of this disease. Recently, herbal medicines have shown a significant impact on inflammatory diseases such as CRS, and one of these herbal medicines is Nigella sativa . Therefore, the current study aimed to evaluate the effectiveness of N. sativa in patients with CRS without nasal polyp (CRSsNP). Methods: In this randomized clinical trial, 65 patients with mild to moderate CRSsNP were enrolled based on the inclusion criteria...
January 2018: Allergy & Rhinology
Megan E Falls, Michael P Rabinowitz, Jacqueline R Carrasco, Mindy R Rabinowitz
Background: Fraser syndrome is an autosomal recessive disorder characterized primarily by syndactyly, cryptophthalmos, urinary tract anomalies, ambiguous genitalia, and laryngeal anomalies. A 28-year-old man with Fraser syndrome presented with cryptophthalmos, microphthalmia, lacrimal system dysgenesis, and chronic sinusitis. Objective: The patients' clinical condition and surgical treatment are described. A literature review was conducted, and articles relevant to the case are presented...
January 2018: Allergy & Rhinology
John Ward, Renee Ciesla, William Becker, Gilbert Marava Shanga
Background: External nasal dilator strips are used as nonpharmacological therapy to reduce snoring and daytime sleepiness. In a product improvement initiative, a marketed strip (BRNS) and 2 prototype nasal strips were evaluated. Objective: To compare the nasal patency and multiple-use dermal tolerability of the BRNS and prototype nasal strips using both objective and subject-reported outcome measures. Methods: Two studies were conducted separately in healthy volunteers ≥18 years of age...
January 2018: Allergy & Rhinology
(no author information available yet)
[This corrects the article DOI: 10.1177/2152656718783630.].
January 2018: Allergy & Rhinology
Hetal K Marfatia, Kartik A Parelkar, Adhara Chakraborty, Shampa Mishra
Background: Pediatric patients presenting with a nasal mass is uncommon and a high index of suspicion for it to be a meningoencephalocele is essential. Majority of these are congenital and require early intervention owing to the risk of meningitis. Surgery in these cases is very challenging because of the risk of anesthesia and limited space. Objective: This study aimed to describe our technique and experience in managing pediatric meningoencephaloceles. Methods: A retrospective study of 19 pediatric patients (age ranging from 40-day-old infants to 11...
January 2018: Allergy & Rhinology
Devasahayam J Christopher, Narmada Ashok, Aruna Ravivarma, Deepa Shankar, Erik Peterson, Phuong T Dinh, P K Vedanthan
Background: Skin prick testing is the most important diagnostic tool to detect immunoglobulin E-mediated allergic diseases. With increase in the number of allergy tests performed in India, it is imperative to know the potency of indigenous extracts in comparison with U.S. Food and Drug Administration (USFDA)-approved extracts. Methods: A randomized comparison trial of Indian manufactured and USFDA-approved extracts of Dermatophagoides pteronyssinus (DP) and Dermatophagoides farinae (DF) was done at Christian Medical College & Hospital, Vellore, India from April 2014 to June 2015, to compare the skin test reactivity of indigenous allergen extracts of dust mites against validated allergen...
January 2018: Allergy & Rhinology
Amber N Pepper, Adeeb Bulkhi, Catherine R Smith, Matthias Colli, Karl-Christian Bergmann, Torsten Zuberbier, Thomas B Casale
Rationale: Vehicle interiors are an important microenvironment for atopic subjects. This study evaluated the subjective and objective physiologic and clinical effects of exposing subjects with asthma and allergic rhinitis to new 2017 Mercedes vehicles during 90-minute rides. Methods: Ten adult asthmatics with allergic rhinitis were assessed before and 45 and 90 minutes into rides in a 2017 Mercedes-Benz S-Class sedan and GLE-Class SUV on 2 separate days. Assessments included spirometry, fractional exhaled nitric oxide, peak nasal inspiratory flow, asthma symptom scores, and physical examinations...
January 2018: Allergy & Rhinology
Hayat Adib, Mohamad Ali El Natout, Georges Zaytoun, Usamah Al Hadi
Introduction: Rhinolithiasis is a rare entity; it entails a stone located in the nasal cavity. The entity presents with different signs and symptoms that can be easily confused with other more common clinical entities such as chronic rhinosinusitis. However, it can also mimic sinonasal tumors, making its proper diagnosis crucial. Materials and Methods: In this article, we present a case series of 15 patients over the past 13 years between 2002 and 2015 who were seen in the clinics at the American University of Beirut Medical Center...
January 2018: Allergy & Rhinology
(no author information available yet)
[This corrects the article DOI: 10.1177/2152656718783599.].
January 2018: Allergy & Rhinology
Vijay R Ramakrishnan, Justin Holt, Leah F Nelson, Diana Ir, Charles E Robertson, Daniel N Frank
Introduction: A role for bacteria and other microbes has long been suspected in the chronic inflammatory sinonasal diseases. Recent studies utilizing culture-independent, sequence-based identification have demonstrated aberrant shifts in the sinus microbiota of chronic rhinosinusitis subjects, compared with ostensibly healthy controls. Examining how such microbiota shifts occur and the potential for physician-prescribed interventions to influence microbiota dynamics are the topics of the current article...
January 2018: Allergy & Rhinology
Rodrigo Collado-Chagoya, Javier Hernández-Romero, Gumaro A Eliosa-Alvarado, Rubén A Cruz-Pantoja, Rosa I Campos-Gutiérrez, Andrea A Velasco-Medina, Guillermo Velázquez-Sámano
Tolerance induction and desensitization in Stevens-Johnson syndrome (SJS) or in toxic epidermal necrolysis (TEN) have been described as an absolute contraindication by some authors, but there are cases where there is no treatment alternative. Tuberculosis (TB) remains a leading cause of morbidity and mortality in developing countries and ranks alongside HIV as a leading cause of death worldwide. Severe drug reactions, such as SJS and TEN, occurring in these individuals are lifethreatening. Since alternative therapies for TB are limited, the role of desensitization and reintroduction becomes essential...
January 2018: Allergy & Rhinology
Eduardo R Urdaneta, Mitesh K Patel, Kathleen B Franklin, Xiaoyan Tian, Mei-Miau Wu
Background: Cetirizine has been shown to be effective for relief of seasonal allergic rhinitis (SAR) symptoms. Allergic rhinitis symptoms have been reported to have circadian variations, with symptoms tending to be most bothersome overnight and in the morning. Objective: To evaluate the effects of different cetirizine dosing schedules in comparison to twice daily (BID) chlorpheniramine and placebo on SAR symptoms at 12 and 24 hours postdose. Methods: Study 1 subjects received cetirizine 10-mg once daily in the morning (QAM), cetirizine 10-mg once daily at bedtime (QHS), cetirizine 5-mg twice daily, or placebo...
January 2018: Allergy & Rhinology
Kazuhiro Hashiguchi, Kimihiro Okubo, Yoichi Inoue, Hirotaka Numaguchi, Kumi Tanaka, Nobuyuki Oshima, Anish Mehta, Chisato Nishida, Itori Saito, George Philip
Background: This study evaluated the efficacy of montelukast in reducing seasonal allergic rhinitis symptoms in Japanese children with Japanese cedar (JC) pollinosis induced in an artificial exposure chamber (OHIO Chamber). Methods: Pediatric patients aged 10 to 15 years sensitive to JC pollen entered a randomized, double-blind, single-site, crossover study. After confirmation of an allergic response to a JC pollen exposure for 3 hours in the OHIO Chamber during the screening period, subjects received either montelukast 5 mg chewable tablets or placebo for a 7-day treatment period, followed by a 3-hour pollen exposure in the chamber...
January 2018: Allergy & Rhinology
Nikhil G Rao, Ambuj Kumar, Jenny S Wong, Ravi Shridhar, Dharendra Y Goswami
Background: Photoelectrochemical oxidation (PECO) is a new air purification technology developed to reduce circulating indoor allergens. PECO removes particles as small as 0.1 nm with the destruction of organic matter otherwise not trapped by a traditional filter and removes volatile organic compounds. Objective: We hypothesized that with daily use, the device would reduce user nasal and ocular allergy total symptom scores (TSS) within 4 weeks. Methods: The study was performed among 46 individuals with self-reported allergies using a portable PECO air purifier...
January 2018: Allergy & Rhinology
Urs C Steiner, Lucas M Bachmann, Micheal B Soyka, Stephan Regenass, Lukas Steinegger, Elsbeth Probst
Background: Rhinitis is a very common disease with allergies being the most frequent causative factor. It can co-occur together with asthma and eczema in atopic as well as in nonatopic patients. Objectives: To assess the prevalence of allergic sensitization within patient groups with rhinitis in consideration of the co-occurring disorders of asthma and eczema. Methods: Students of the third year of medical school completed an anonymous questionnaire on age, gender, and clinical symptoms, such as seasonal rhinitis, perennial rhinitis, asthma, and eczema, and underwent an ImmunoCAP Rapid test...
January 2018: Allergy & Rhinology
Alexander Yao, Janet A Wilson, Stephen L Ball
Background: The autonomic nervous system (ANS) richly innervates the nose and paranasal sinuses, and has a significant role in lower airway diseases, e.g., asthma. Nonetheless, its contribution to sinonasal symptoms is poorly understood. This review aimed to explore the complex relationship between the ANS and sinonasal symptoms, with reference to systemic diseases and triggers of ANS dysfunction. Methods: A review of articles published in English was conducted by searching medical literature databases with the key words "autonomic nervous system" and ("sinusitis" or "nose" or "otolaryngology")...
January 2018: Allergy & Rhinology
James A Gallogly, Farhoud Faraji, Mejd H Jumaily, John S Schneider, Joseph D Brunworth
Background: Due to the proximity of the maxillary sinus and ethmoid sinuses to the orbit, inflammatory processes that originate in the sinonasal region have the potential to extend into the orbit. Objective: We presented a case of ptosis and restrictive strabismus of the medial rectus muscle. Methods: A case report with a literature review of possible diagnoses. Results: Biopsy, imaging, and laboratory evaluation by otolaryngology, ophthalmology, and rheumatology services were unable to identify the cause of the fibrosis after 22 months of follow-up...
January 2018: Allergy & Rhinology
Theodore A Schuman, Adam J Kimple, Claire H Edgerly, Charles S Ebert, Adam M Zanation, Brian D Thorp
Background: Epithelial-myoepithelial carcinoma (EMC) is a rare tumor of the major and minor salivary glands. Sinonasal EMC is extremely uncommon and hitherto not described within the frontal or ethmoid sinuses. Objective: To present a novel sinonasal subsite and review the literature regarding sinonasal EMC. Methods: A case of frontoethmoidal EMC was presented. A medical literature data base was queried from January 1, 1950, to August 8, 2017, for all reports of sinonasal EMC...
January 2018: Allergy & Rhinology
Shikhar Sawhney, Sandeep Bansal, Madhur Kalyan, Indu Verma, Ramandeep Singh Virk, Ashok Kumar Gupta
Background: Ever since its characterization in the 1970s, allergic fungal rhinosinusitis (AFRS) has been the subject of much controversy, especially regarding its pathogenesis. In this study, we analyzed the differential expression of genes that encode protease-activated receptors (PAR) in patients with AFRS and patients with chronic rhinosinusitis, and tried to understand the pathogenic basis of this disease. Objective: To analyze the differential expression of PAR genes in patients with AFRS and in patients with chronic rhinosinusitis...
January 2018: Allergy & Rhinology
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