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Brain and Behavior

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https://www.readbyqxmd.com/read/29299392/rapid-neurophysiological-screening-for-sensory-ganglionopathy-a-novel-approach
#1
Panagiotis Zis, Marios Hadjivassiliou, Ptolemaios Georgios Sarrigiannis, Alexander St John Edward Barker, Dasappaiah Ganesh Rao
Background and Aim: Pure sensory neuropathies involving the dorsal root ganglia are commonly referred to as sensory ganglionopathies (SG). Causes of SG can be inherited (as seen in Friedreich's ataxia) or acquired (e.g. immune-mediated or paraneoplastic). Diagnostic criteria for confirming SG have been published and consist of a combination of clinical and neurophysiological parameters. The aim of our study was to develop a neurophysiological method for rapid screening for diagnosis of SG...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299391/the-auditory-comprehension-changes-over-time-after-sport-related-concussion-can-indicate-multisensory-processing-dysfunctions
#2
Anita Białuńska, Anthony P Salvatore
Background: Although science findings and treatment approaches of a concussion have changed in recent years, there continue to be challenges in understanding the nature of the post-concussion behavior. There is growing a body of evidence that some deficits can be related to an impaired auditory processing. Purpose: To assess auditory comprehension changes over time following sport-related concussion (SRC) in young athletes. Methods: A prospective, repeated measures mixed-design was used...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299390/cortical-morphology-in-patients-with-transient-global-amnesia
#3
Hyung Chan Kim, Byung In Lee, Sung Eun Kim, Kang Min Park
Objective: This study evaluated alterations in cortical morphology in patients with transient global amnesia (TGA). Materials and Methods: Diagnoses of TGA occurred at our hospital. Evaluation involved a structured interview to obtain clinical information and a brain magnetic resonance imaging scan. We analyzed whole-brain T1-weighted MRI data using FreeSurfer 5.1. Measures of cortical morphology, such as thickness, surface area, volume, and curvature were compared between patients with TGA and healthy controls...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299389/cd226-deficiency-improves-cognitive-functions-and-ameliorates-anxiety-like-behaviors-in-mice
#4
Liang Fang, Jingyi Jin, Ping Chen, Ning Wang, Hanyu Zeng, Boquan Jin, Hui Li, Lihua Chen
Background: CD226 is a cell surface adhesion molecule expressed in the immune system and central nervous system. Although the role of CD226 in the function of immune cells has been well studied, there has been no report on the potential functional significance of CD226 in neural cells. Methods: We investigated the role of CD226 on the cognitive function and behaviors using CD226 knockout (CD226KO) and wild-type mice. The spatial learning and memory were characterized using Morris water maze test, and the behaviors were evaluated using open field and elevated plus maze tests...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299388/individual-differences-in-eeg-correlates-of-recognition-memory-due-to-dat-polymorphisms
#5
Paolo Medrano, Erika Nyhus, Andrew Smolen, Tim Curran, Robert S Ross
Introduction: Although previous research suggests that genetic variation in dopaminergic genes may affect recognition memory, the role dopamine transporter expression may have on the behavioral and EEG correlates of recognition memory has not been well established. Objectives: The study aims to reveal how individual differences in dopaminergic functioning due to genetic variations in the dopamine transporter gene influences behavioral and EEG correlates of recognition memory...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299387/codeine-is-associated-with-poor-prognosis-in-acute-stroke
#6
Stian T Ryste, Bernt A Engelsen, Halvor Naess
Background: The aim of this study was to investigate how the use of analgesics, sleeping drugs, and sedatives relates to prognosis and complications in stroke patients in the acute care phase (≤48 hr) after a stroke. Materials and Methods: Patients with ischemic stroke, hemorrhagic stroke, and transient ischemic attack were included. The study is based on gathering of data on medication from 921 patient records belonging to patients included in the Bergen NORSTROKE registry, 12...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299386/serum-sodium-and-chloride-are-inversely-associated-with-dyskinesia-in-parkinson-s-disease-patients
#7
Cheng-Jie Mao, Chong-Ke Zhong, Yong Yang, Ya-Ping Yang, Fen Wang, Jing Chen, Jin-Ru Zhang, Hui-Jun Zhang, Hong Jin, Ling-Li Xu, Juan-Ying Huang, Chun-Feng Liu
Objective: We aim to report and evaluate the associations between serum sodium and chloride and dyskinesia in patients with Parkinson's disease. One hundred and two patients with Parkinson's disease were enrolled in this study. Methods: Patients' serum electrolytes including sodium, calcium, potassium, magnesium, and chloride were measured. Other demographic information was collected, and Unified Parkinson's disease rating scale and Hoehn and Yahr stage scale were also performed...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299385/sight-impairment-registration-due-to-stroke-a-small-yet-significant-rise
#8
Catey Bunce, Antra Zekite, Richard Wormald, Fiona Rowe
Objectives: In the United Kingdom, when an individual's sight falls to and remains at a certain threshold, they may be offered registration as sight impaired. Recent analysis of causes of registrable sight impairment in England/Wales indicated that visual impairment due to stroke had increased as a proportionate cause of sight loss. We aim to assess whether there is evidence of an increase in incidence of certification for sight impairment due to stroke in England/Wales between 2008 and 2014...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299384/effect-of-early-hospital-readmission-and-comorbid-conditions-on-subsequent-long-term-mortality-after-transient-ischemic-attack
#9
Mohammed Yousufuddin, Nathan Young, Lawrence Keenan, Tammy Olson, Jessica Shultz, Taylor Doyle, Eimad Ahmmad, Kogulavadanan Arumaithurai, Paul Takahashi, Mohammad Hassan Murad
Background: The implications of early readmission on long-term mortality after transient ischemic attack (TIA) are not known. We aimed at examining the effect of 180-day readmission on subsequent long-term mortality after index hospitalization for TIA. Methods: A retrospective study of patients hospitalized for first-ever TIA at Mayo Clinic from 2000 through 2017. Patients readmitted within 180 days postdischarge were compared with those not readmitted in long-term risk of death...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299383/the-short-and-long-term-efficacy-analysis-of-stereotactic-surgery-combined-external-ventricular-drainage-in-the-treatment-of-the-secondary-intraventricular-hemorrhage
#10
Wei Yi Han, Ying Qun Tao, Feng Xu, You Qian Zhang, Zhi Yong Li, Guo Biao Liang
Objective: To evaluate the clinical value of minimally invasive stereotactic puncture therapy (MISPT) combined with external ventricular drainage (EVD) on secondary intraventricular hemorrhage (SIVH). Methods: A retrospective analysis of the patients of intraventricular hemorrhage from May 2013 to January 2015 was conducted in our hospital, according to the enrollment criterion; of which 40 patients were treated by MISPT combined with EVD (ME group) and 45 patients by conventional craniotomy combined with EVD (CE group)...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299382/an-interspecies-comparative-study-of-invasive-electrophysiological-functional-connectivity
#11
Kaitlyn Casimo, Lila H Levinson, Stavros Zanos, C Alexis Gkogkidis, Tonio Ball, Eberhard Fetz, Kurt E Weaver, Jeffrey G Ojemann
Introduction: Resting-state connectivity patterns have been observed in humans and other mammal species, and can be recorded using a variety of different technologies. Functional connectivity has been previously compared between species using resting-state fMRI, but not in electrophysiological studies. Methods: We compared connectivity with implanted electrodes in humans (electrocorticography) to macaques and sheep (microelectrocorticography), which are capable of recording neural data at high frequencies with spatial precision...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299381/the-m-7510t-c-mutation-hearing-impairment-and-a-complex-neurologic-phenotype
#12
Laura Kytövuori, Maria Gardberg, Kari Majamaa, Mika H Martikainen
Objectives: Mutations in mitochondrial DNA cause a variety of clinical phenotypes ranging from a mild hearing impairment (HI) to severe encephalomyopathy. The MT-TS1 gene is a hotspot for mutations causing HI. The m.7510T>C mutation in MT-TS1 has been previously associated with non-syndromic HI in four families from different ethnic backgrounds. Materials and Methods: We describe the clinical, genetic, and histopathological findings in a Finnish family with the heteroplasmic m...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299380/higher-extrinsic-and-lower-intrinsic-connectivity-in-resting-state-networks-for-professional-baduk-go-players
#13
William S Sohn, Tae Young Lee, Seoyeon Kwak, Youngwoo Bryan Yoon, Jun Soo Kwon
Introduction: Dedication and training to a profession results in a certain level of expertise. This expertise, like any other skill obtained in our lifetime, is encoded in the brain and may be reflected in our brain's connectome. This property can be observed by mapping resting state connectivity. In this study, we examine the differences in resting state functional connectivity in four major networks between professional "Baduk" (Go) players and normal subjects. Methods: Resting state fMRI scans were acquired for professional "Baduk" (Go) players and normal controls...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299379/headache-in-the-first-manifestation-of-multiple-sclerosis%C3%A2-%C3%A2-prospective-multicenter-study
#14
Marcel Gebhardt, Peter Kropp, Tim P Jürgens, Frank Hoffmann, Uwe K Zettl
Objectives: Multiple sclerosis (MS) is the most frequent immune-mediated inflammation of the central nervous system that can lead to early disability. Headaches have not been considered as MS-related symptoms initially, whereas higher prevalence rates were reported since 2000. Postmortem histological analyses of MS patients' brains revealed lymphoid follicle-like structures in the cerebral meninges which suggest a possible pathophysiological explanation for the high headache prevalence in MS...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299378/moral-processing-deficit-in-behavioral-variant-frontotemporal-dementia-is-associated-with-facial-emotion-recognition-and-brain-changes-in-default-mode-and-salience-network-areas
#15
Jan Van den Stock, Daphne Stam, François-Laurent De Winter, Dante Mantini, Benedikt Szmrecsanyi, Koen Van Laere, Rik Vandenberghe, Mathieu Vandenbulcke
Introduction: Behavioral variant frontotemporal dementia (bvFTD) is associated with abnormal emotion recognition and moral processing. Methods: We assessed emotion detection, discrimination, matching, selection, and categorization as well as judgments of nonmoral, moral impersonal, moral personal low- and high-conflict scenarios. Results: bvFTD patients gave more utilitarian responses on low-conflict personal moral dilemmas. There was a significant correlation between a facial emotion processing measure derived through principal component analysis and utilitarian responses on low-conflict personal scenarios in the bvFTD group (controlling for MMSE-score and syntactic abilities)...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299377/memory-and-the-hippocampal-formation-following-pediatric-traumatic-brain-injury
#16
Dana DeMaster, Chad Johnson, Jenifer Juranek, Linda Ewing-Cobbs
Introduction: Previous research indicates disruption of learning and memory in children who have experienced traumatic brain injury (TBI). Objective: This research evaluates the impact of pediatric TBI on volumetric differences along the long axis of the hippocampus, a region of the brain that is critical for explicit memory. Methods: Structural brain data and behavioral measures were collected 6 weeks following TBI or extracranial injury (EI), in children aged 8-15 years and from a group of age matched typically developing controls (TDC)...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29299376/aerobic-anti-gravity-exercise-in-patients-with-charcot-marie-tooth-disease-types-1a-and-x-a-pilot-study
#17
Kirsten L Knak, Linda K Andersen, John Vissing
Background: Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy associated with impaired walking capacity. Some patients are too weak in the lower extremity muscles to walk at gravity with sufficient intensity or duration to gain benefit. Aim: The aim was to investigate the effect of aerobic anti-gravity exercise in weak patients with CMT 1A and X. Methods: Five adult patients performed moderate-intensity aerobic anti-gravity exercise 3/week for 10 weeks...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29201557/brain-lesions-affecting-gait-recovery-in-stroke-patients
#18
Kyoung Bo Lee, Joon Sung Kim, Bo Young Hong, Bomi Sul, Seojin Song, Won Jin Sung, Byong Yong Hwang, Seong Hoon Lim
Objectives: Gait recovery is an important goal in stroke patients. Several studies have sought to uncover relationships between specific brain lesions and the recovery of gait, but the effects of specific brain lesions on gait remain unclear. Thus, we investigated the effects of stroke lesions on gait recovery in stroke patients. Materials and Methods: In total, 30 subjects with stroke were assessed in a retrograde longitudinal observational study. To assess gait function, the functional ambulation category (FAC) was tested four times: initially (within 2 weeks) and 1, 3, and 6 months after the onset of the stroke...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29201556/ns-pten-knockout-mice-show-sex-and-age-specific-differences-in-ultrasonic-vocalizations
#19
Matthew S Binder, Joaquin N Lugo
Objective: The goal of this study was to identify changes in quantitative and qualitative aspects of neonatal ultrasonic vocalizations USVs in neuron-subset specific (NS-Pten) knockout males and females when compared with wild-type male and female mice. Background: One signaling cascade that plays a crucial role in the development of an autistic-like phenotype is the PI3K/Akt/mTOR pathway. Mouse models that illustrate this connection include Fmr1, Tsc1, and NS-Pten-deficient mice...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29201555/background-and-distribution-of-lobar-microbleeds-in-cognitive-dysfunction
#20
Hirofumi Matsuyama, Yuichiro Ii, Masayuki Maeda, Maki Umino, Yukito Ueda, Ken-Ichi Tabei, Hirotaka Kida, Masayuki Satoh, Akihiro Shindo, Akira Taniguchi, Ryosuke Takahashi, Hidekazu Tomimoto
Objectives: Cerebral microbleeds (CMBs) are often observed in memory clinic patients. It has been generally accepted that deep CMBs (D-CMBs) result from hypertensive vasculopathy (HV), whereas strictly lobar CMBs (SL-CMBs) result from cerebral amyloid angiopathy (CAA) which frequently coexists with Alzheimer's disease (AD). Mixed CMBs (M-CMBs) have been partially attributed to HV and also partially attributed to CAA. The aim of this study was to elucidate the differences between SL-CMBs and M-CMBs in terms of clinical features and regional distribution...
November 2017: Brain and Behavior
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