journal
MENU ▼
Read by QxMD icon Read
search

Brain and Behavior

journal
https://www.readbyqxmd.com/read/28828228/the-impact-of-hemodynamic-variability-and-signal-mixing-on-the-identifiability-of-effective-connectivity-structures-in-bold-fmri
#1
Natalia Z Bielczyk, Alberto Llera, Jan K Buitelaar, Jeffrey C Glennon, Christian F Beckmann
PURPOSE: Multiple computational studies have demonstrated that essentially all current analytical approaches to determine effective connectivity perform poorly when applied to synthetic functional Magnetic Resonance Imaging (fMRI) datasets. In this study, we take a theoretical approach to investigate the potential factors facilitating and hindering effective connectivity research in fMRI. MATERIALS AND METHODS: In this work, we perform a simulation study with use of Dynamic Causal Modeling generative model in order to gain new insights on the influence of factors such as the slow hemodynamic response, mixed signals in the network and short time series, on the effective connectivity estimation in fMRI studies...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828227/a-novel-p-t139m-mutation-in-hspb1-highlighting-the-phenotypic-spectrum-in-a-family
#2
Jakkrit Amornvit, Mehmet E Yalvac, Lei Chen, Zarife Sahenk
INTRODUCTION: Mutations in the HSPB1 gene encoding the small heat shock protein B1 are associated with an autosomal dominant, axonal form of Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy. Recently, distal myopathy had been described in a patient carrying HSPB1 mutation adding to the complexity of phenotypes resulting from HSPB1 mutations. METHODS: Five patients in a family with concerns of hereditary neuropathy were included. Detailed clinical examinations, including assessments of motor and sensory function, and electrophysiological data were obtained...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828226/serum-galectin-3-levels-and-delirium-among-postpartum-intensive-care-unit-women
#3
Ying Zhu, Wei Hu, Ming-Li Zhu, Ting Yin, Jun Su, Jian-Rong Wang
OBJECTIVE: Inflammation correlates with delirium. Galectin-3 is a proinflammatory protein. This study aimed to determine relation of serum galectin-3 levels to delirium of postpartum intensive care unit (ICU) women. MATERIALS AND METHODS: In this prospective observational study, serum galectin-3, S100B, and C-reactive protein levels of 412 postpartum ICU women and 412 healthy women were measured. Delirium and Acute Physiology and Chronic Health Care Evaluation II (APCHCE II) scores were recorded...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828225/quantifying-absolute-glutamate-concentrations-in-nucleus-accumbens-of-prescription-opioid-addicts-by-using-1-h-mrs
#4
Xi-Long Liu, Long Li, Jian-Neng Li, Ji-Hua Tang, Jia-Hui Rong, Bo Liu, Ze-Xuan Hu
INTRODUCTION: The diagnosis of psychoactive substance use disorders has been based primarily on descriptive, symptomatic checklist criteria. In opioid addiction, there are no objective biological indicators specific enough to guide diagnosis, monitor disease status, and evaluate efficacy of therapeutic interventions. Proton magnetic resonance spectroscopy ((1)H MRS) of the brain has potential to identify and quantify biomarkers for the diagnosis of opioid dependence. The purpose of this study was to detect the absolute glutamate concentration in the nucleus accumbens (NAc) of patients with prescription opioid dependence using (1)H MRS, and to analyze its clinical associations...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828224/social-and-environmental-enrichment-has-different-effects-on-ethanol-and-sucrose-consumption-in-mice
#5
Joan Y Holgate, Hilary Garcia, Susmita Chatterjee, Selena E Bartlett
BACKGROUND: Factors leading to the harmful consumption of substances, like alcohol and sucrose, involve a complex interaction of genes and the environment. While we cannot control the genes we inherit, we can modify our environment. Understanding the role that social and environmental experiences play in alcohol and sucrose consumption is critical for developing preventative interventions and treatments for alcohol use disorders and obesity. METHODS: We used the drinking in the dark two-bottle choice (2BC) model of ethanol and sucrose consumption to compare male C57BL/6 mice housed in the IntelliCage (an automated device capable of simultaneously measuring behaviors of up to 16 mice living in an enriched social environment) with mice housed in standard isolated and social environments...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828223/effects-of-haloperidol-olanzapine-ziprasidone-and-pha-543613-on-spatial-learning-and-memory-in-the-morris-water-maze-test-in-na%C3%A3-ve-and-mk-801-treated-mice
#6
Houxu Ning, Dong Cao, Haidong Wang, Bing Kang, Shiping Xie, Yujing Meng
INTRODUCTION: Cognitive impairment is the core symptom of schizophrenia, significantly impacting the functional outcome. Improvement of cognitive function has been an important aspect of the treatment of schizophrenia. Therefore, this study is to demonstrate the effects of first-generation antipsychotic haloperidol, second-generation antipsychotic olanzapine and ziprasidone, and alpha-7 nicotinic acetylcholine receptor agonist PHA-543613 on spatial learning and memory. MATERIAL AND METHODS: C57BL/6 mice received intraperitoneal injections of haloperidol (2 mg/kg), olanzapine (2...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828222/longitudinal-study-of-neuropathy-microangiopathy-and-autophagy-in-sural-nerve-implications-for-diabetic-neuropathy
#7
Simin Mohseni, Medeea Badii, Axel Kylhammar, Niels O B Thomsen, Karl-Fredrik Eriksson, Rayaz A Malik, Ingmar Rosén, Lars B Dahlin
OBJECTIVES: The progression and pathophysiology of neuropathy in impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) is poorly understood, especially in relation to autophagy. This study was designed to assess whether the presence of autophagy-related structures was associated with sural nerve fiber pathology, and to investigate if endoneurial capillary pathology could predict the development of T2DM and neuropathy. PATIENTS AND METHODS: Sural nerve physiology and ultrastructural morphology were studied at baseline and 11 years later in subjects with normal glucose tolerance (NGT), IGT, and T2DM...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828221/vitamin-d-supplementation-differentially-affects-seasonal-multiple-sclerosis-disease-activity
#8
Andrei Miclea, Marius Miclea, Maximilian Pistor, Andreas Hoepner, Andrew Chan, Robert Hoepner
OBJECTIVES: Low ultraviolet-B (UVB) radiation causes hypovitaminosis D, which is a known risk factor for multiple sclerosis (MS) and associated with MS disease activity. Our objective is to test whether vitamin D supplementation is most effective in lowering disease activity during the period of the year with low UVB radiation and consequently low serum 25-hydroxyvitamin D3 (25(OH)D3) concentration. METHODS: Retrospective analysis of medical records from our outpatient department identified 40 MS patients with available data of at least 6 months before and during oral vitamin D supplementation...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828220/a-waves-increase-the-risk-of-developing-neuropathy
#9
Iva Srotova, Eva Vlckova, Ladislav Dusek, Josef Bednarik
INTRODUCTION: A-waves, which are observed following the M-wave during motor nerve conduction studies (NCS), are late responses that are frequently found in many types of neurogenic disorders. However, A-waves are also common in healthy individuals, where their significance remains unclear. The aim of this study was to examine whether the occurrence of A-waves does in fact represent an increased risk for the future development of changes upon NCS or needle electromyography (EMG) in the corresponding nerve...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828219/long-term-safety-and-effectiveness-of-levodopa-carbidopa-intestinal-gel-infusion
#10
Oriol De Fabregues, Joan Dot, Monder Abu-Suboh, Jorge Hernández-Vara, Alex Ferré, Odile Romero, Marta Ibarria, José Luis Seoane, Nuria Raguer, Carolina Puiggros, Maria Rosa Gómez, Manuel Quintana, Josep Ramon Armengol, José Alvarez-Sabín
INTRODUCTION: Levodopa-carbidopa intestinal gel (LCIG) infusion has demonstrated to improve motor fluctuations. The aim of this study is to assess the long-term safety and effectiveness of LCIG infusion in advanced Parkinson's disease (PD) patients with motor fluctuations and its effect in nonmotor symptoms. METHODS: Adverse events (AE) and their management, clinical motor, and nonmotor aspects were assessed up to 10 years. Thirty-seven patients were treated with LGIC; in three subsets of patients, specific batteries of tests were used to assess cognitive and behavior assessment for 6 months, quality of sleep for 6 months, and quality of life and caregiver burden for 1 year...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828218/recruitment-of-orbitofrontal-cortex-during-unpredictable-threat-among-adults-at-risk-for-affective-disorders
#11
Namik Kirlic, Robin L Aupperle, Masaya Misaki, Rayus Kuplicki, Ruben P Alvarez
BACKGROUND: Mood and anxiety disorders are characterized by altered prefrontal-amygdala function and increased behavioral inhibition (BI) in response to potential threat. Whether these alterations constitute a vulnerability or a symptom of illness remains unclear. The medial orbitofrontal cortex (mOFC) is thought to play a central role in estimating probability and cost of threat, in turn informing selection of subsequent behaviors. To better understand the behavioral and neural processes that may be associated with risk for psychopathology, we used a virtual reality paradigm to examine behavioral and neural responses of psychiatrically healthy adults with familial history of affective disorders during anticipation of unpredictable threat...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828217/a-pilot-study-on-the-effects-of-probiotic-supplementation-on-neuropsychological-performance-and-microrna-29a-c-levels-in-antiretroviral-treated-hiv-1-infected-patients
#12
Giancarlo Ceccarelli, Mariangela Fratino, Carla Selvaggi, Noemi Giustini, Sara Serafino, Ivan Schietroma, Giuseppe Corano Scheri, Paolo Pavone, Giulia Passavanti, Danilo Alunni Fegatelli, Ivano Mezzaroma, Guido Antonelli, Vincenzo Vullo, Carolina Scagnolari, Gabriella d'Ettorre
INTRODUCTION: The gut microbiota is involved in the regulation of cognition, mood, anxiety, and pain, and can impact cognitive functions by producing neuroactive substances or releasing bacterial by-products and metabolites. No information is available on the effects of a probiotic supplementation on brain function of HIV+ subjects. In light of the above considerations, we performed a pilot study in cART-treated HIV-1-positive patients with long-term virologic suppression. The aims were to analyze the effect of high-concentration multistrain probiotic supplementation (Vivomixx®; Visbiome®) on several neurocognitive abilities and to evaluate the safety of this supplementation...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828216/sciatic-nerve-repair-using-poly-%C3%AE%C2%B5-caprolactone-tubular-prosthesis-associated-with-nanoparticles-of-carbon-and-graphene
#13
Kyl Assaf, Claudenete Vieira Leal, Mariana Silveira Derami, Eliana Aparecida de Rezende Duek, Helder Jose Ceragioli, Alexandre Leite Rodrigues de Oliveira
INTRODUCTION: Injuries to peripheral nerves generate disconnection between spinal neurons and the target organ. Due to retraction of the nerve stumps, end-to-end neurorrhaphy is usually unfeasible. In such cases, autologous grafts are widely used, nonetheless with some disadvantages, such as mismatching of donor nerve dimensions and formation of painful neuromas at the donor area. Tubulization, using bioresorbable polymers, can potentially replace nerve grafting, although improvements are still necessary...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828215/cortical-thickness-and-subcortical-structure-volume-abnormalities-in-patients-with-major-depression-with-and-without-anxious-symptoms
#14
Ke Zhao, Haiyan Liu, Rui Yan, Lingling Hua, Yu Chen, Jiabo Shi, Qing Lu, Zhijian Yao
BACKGROUND: Anxious depression is one of the common subtypes of major depressive disorder (MDD). Clinically, patients with anxious depression exhibit more severe depressive symptoms than patients with nonanxious depression. The aim of the present study was to explore the common and differing cortical and subcortical structural changes between patients with anxious and nonanxious depression. METHODS: Patients were placed into one of three groups: the anxious depression group (MDD patients with high levels of anxiety symptoms, n = 23), the nonanxious depression group (n = 22), and healthy controls (n = 43) that were matched for age, sex, and education level...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828214/diffusion-tensor-imaging-of-the-structural-integrity-of-white-matter-correlates-with-impulsivity-in-adolescents-with-internet-gaming-disorder
#15
Xin Du, Linlin Liu, Yongxin Yang, Xin Qi, Peihong Gao, Yang Zhang, Jiyu Zhu, Guijin Du, Shouping Dai, Xiaodong Li, Quan Zhang
INTRODUCTION: Internet gaming disorder (IGD) is usually defined as the inability of an individual to control internet gaming resulting in serious negative consequences, and trait impulsivity has been viewed as a hallmark feature of IGD. Recent studies have suggested that the structural integrity of the white matter (WM) plays an important role in the neuromediation of an individual's impulsivity. However, no study has examined the association between WM integrity and impulsivity in IGD adolescents...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828213/human-urinary-kallidinogenase-promotes-good-recovery-in-ischemic-stroke-patients-with-level-3-hypertension
#16
Danhong Wu, Yi Lyu, Ping Zhong, Fengdi Liu, Xueyuan Liu
AIM: To evaluate the clinical efficacy of Human Urinary kallidinogenase (HUK) in the treatment of acute ischemic stroke (AIS) patients with level 3 hypertension. METHODS: In this retrospective study, from January 2015 to June 2016, 150 consecutive AIS patients were registered in our database. Among them, 47 with level 3 hypertension received either HUK treatment (HUK group, 22 cases) or basic treatment (control group, 25 cases). Basic treatment was administrated on all patients...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828212/can-we-predict-drug-response-by-volumes-of-the-corpus-callosum-in-newly-diagnosed-focal-epilepsy
#17
Hyung Chan Kim, Sung Eun Kim, Byung In Lee, Kang Min Park
OBJECTIVE: The aim of this study was to investigate whether volumes of the corpus callosum could predict a response to antiepileptic drugs in patients with newly diagnosed focal epilepsy. METHODS: Fifty-three patients with newly diagnosed focal epilepsy of unknown etiology and healthy subjects were enrolled in this study. First, we analyzed the differences in the volumes of the corpus callosum between patients with epilepsy and healthy subjects. Second, we divided patients with epilepsy into antiepileptic drug responders and drug nonresponders groups, according to their seizure controls, and evaluated the differences in the volumes of the corpus callosum between the groups...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828211/duplex-ultrasonography-for-the-detection-of-vertebral-artery-stenosis-a-comparison-with-ct-angiography
#18
Anouk D Rozeman, Hajo Hund, Michel Westein, Marieke J H Wermer, Geert J Lycklama À Nijeholt, Jelis Boiten, Robert-Jan Schimsheimer, Ale Algra
OBJECTIVES: Vertebrobasilar stenosis is frequent in patients with posterior circulation stroke and it increases risk of recurrence. We investigated feasibility of duplex ultrasonography (DUS) for screening for extracranial vertebral artery stenosis and compared it with CT angiography (CTA). MATERIALS AND METHODS: We gathered data on 337 consecutive patients who had DUS because of posterior circulation stroke or TIA. Matching CTA studies were retrieved and used as reference...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828210/short-and-long-term-antidepressant-effects-of-ketamine-in-a-rat-chronic-unpredictable-stress-model
#19
Yinghong Jiang, Yiqiang Wang, Xiaoran Sun, Bo Lian, Hongwei Sun, Gang Wang, Zhongde Du, Qi Li, Lin Sun
OBJECTIVE: This research was aimed to evaluate the behaviors of short- or long-term antidepressant effects of ketamine in rats exposed to chronic unpredictable stress (CUS). BACKGROUND: Ketamine, a glutamate noncompetitive NMDA receptor antagonist, regulates excitatory amino acid functions, such as anxiety disorders and major depression, and plays an important role in synaptic plasticity and learning and memory. METHODS: After 42 days of CUS model, male rats received either a single injection of ketamine (10 mg/kg; day 43) or 15 daily injections (days 43-75)...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828209/prevalence-for-delirium-in-stroke-patients-a-prospective-controlled-study
#20
Peter Nydahl, Gabriele Bartoszek, Andreas Binder, Laura Paschen, Nils G Margraf, Karsten Witt, Andre Ewers
BACKGROUND AND PURPOSE: This study investigates the prevalence of delirium in acute stroke patients on a primary stroke unit (SU) analyzing associated risk factors and clinical outcomes. METHOD: Prospective, 4-month observational study from 2015 to 2016 on patients aged ≥18 years with stroke at a German university hospital's SU. The presence of delirium as first outcome was rated at three times daily using the Confusion Assessment Method (CAM). Secondary outcome measures were duration of delirium, rehabilitation in SU, length of stay in SU and hospital, complications, and mortality...
August 2017: Brain and Behavior
journal
journal
43782
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"