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Journal of Functional Biomaterials

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https://www.readbyqxmd.com/read/29104215/evaluation-of-pbs-treatment-and-pei-coating-effects-on-surface-morphology-and-cellular-response-of-3d-printed-alginate-scaffolds
#1
María A Mendoza García, Mohammad Izadifar, Xiongbiao Chen
Three-dimensional (3D) printing is an emerging technology for the fabrication of scaffolds to repair/replace damaged tissue/organs in tissue engineering. This paper presents our study on 3D printed alginate scaffolds treated with phosphate buffered saline (PBS) and polyethyleneimine (PEI) coating and their impacts on the surface morphology and cellular response of the printed scaffolds. In our study, sterile alginate was prepared by means of the freeze-drying method and then, used to prepare the hydrogel for 3D printing into calcium chloride, forming 3D scaffolds...
November 1, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29035303/optimization-of-bicomponent-electrospun-fibers-for-therapeutic-use-post-treatments-to-improve-chemical-and-biological-stability
#2
Antonio Papa, Vincenzo Guarino, Valentina Cirillo, Olimpia Oliviero, Luigi Ambrosio
Bicomponent electrospun nanofibers based on the combination of synthetic (i.e., aliphatic polyesters such as polycaprolactone (PCL)) and natural proteins (i.e., gelatin) have been extensively investigated as temporary platforms to instruct cells by the release of molecular/pharmaceutical signals for the regeneration of several tissues. Here, water soluble proteins (i.e., gelatin), strictly embedded to PCL, act as carriers of bioactive molecules, thus improving bioavailability and supporting cell activities during in vitro regeneration...
October 16, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28991207/fe-core-carbon-shell-nanoparticles-as-advanced-mri-contrast-enhancer
#3
Rakesh P Chaudhary, Kim Kangasniemi, Masaya Takahashi, Samarendra K Mohanty, Ali R Koymen
The aim of this study is to fabricate a hybrid composite of iron (Fe) core-carbon (C) shell nanoparticles with enhanced magnetic properties for contrast enhancement in magnetic resonance imaging (MRI). These new classes of magnetic core-shell nanoparticles are synthesized using a one-step top-down approach through the electric plasma discharge generated in the cavitation field in organic solvents by an ultrasonic horn. Transmission electron microscopy (TEM) observations revealed the core-shell nanoparticles with 10-85 nm in diameter with excellent dispersibility in water without any agglomeration...
October 9, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28956821/in-vitro-findings-of-titanium-functionalized-with-estradiol-via-polydopamine-adlayer
#4
Chris Steffi, Zhilong Shi, Chee Hoe Kong, Wilson Wang
To improve orthopedic implant fixation and reduce post-operative complications, osteogenic molecules are delivered locally by immobilizing them on the surface of implants, which will modulate the biology of cell attachment and differentiation on the implant surface. Estradiol, a natural steroid hormone, maintains bone metabolism by decreasing bone resorption. It either directly or indirectly affects osteoclasts. In this work, estradiol was immobilized on a titanium surface by polydopamine adlayer. Immobilization of estradiol was confirmed by X-ray electron spectroscopy (XPS), immunofluorescence staining and enzyme-linked immunosorbent assay (ELISA)...
September 28, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28954399/biodegradable-materials-and-metallic-implants-a-review
#5
REVIEW
Mythili Prakasam, Janis Locs, Kristine Salma-Ancane, Dagnija Loca, Alain Largeteau, Liga Berzina-Cimdina
Recent progress made in biomaterials and their clinical applications is well known. In the last five decades, great advances have been made in the field of biomaterials, including ceramics, glasses, polymers, composites, glass-ceramics and metal alloys. A variety of bioimplants are currently used in either one of the aforesaid forms. Some of these materials are designed to degrade or to be resorbed inside the body rather than removing the implant after its function is served. Many properties such as mechanical properties, non-toxicity, surface modification, degradation rate, biocompatibility, and corrosion rate and scaffold design are taken into consideration...
September 26, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28946629/suitability-of-egcg-as-a-means-of-stabilizing-a-porcine-osteochondral-xenograft
#6
Steven Elder, John Clune, Jaylyn Walker, Paul Gloth
As a non-crosslinked osteochondral xenograft would be mechanically inferior to native cartilage and vulnerable to premature degradation, we seek a safe and effective method of xenograft stabilization. The purpose of this study was to evaluate the capacity for epigallocatechin gallate (EGCG) to stabilize a decellularized porcine osteochondral xenograft through collagen crosslinking. Our objectives were to assess the effects of EGCG on the degree of crosslinking, mechanical properties, collagenase resistance, cytotoxicity, and in vitro biocompatibility...
September 23, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28937598/the-effect-of-rankl-opg-balance-on-reducing-implant-complications
#7
REVIEW
Elizabeth R Kapasa, Peter V Giannoudis, Xiaodong Jia, Paul V Hatton, Xuebin B Yang
Despite the phenomenal success of implants particularly in the realms of dentistry and orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection, prosthetic loosening, and non-union continue to be the most notorious examples. The cascade of fracture healing and bone repair, especially with the presence of an implant, is complex because it involves a multifaceted immune response alongside the intricate process of bone formation and remodelling. Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation, illustrating that there is a convoluted relationship between inflammation and bone erosion...
September 22, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29036882/biomineralization-of-fucoidan-peptide-blends-and-their-potential-applications-in-bone-tissue-regeneration
#8
Harrison T Pajovich, Ipsita A Banerjee
Fucoidan (Fuc), a natural polysaccharide derived from brown seaweed algae, and gelatin (Gel) were conjugated to form a template for preparation of biomimetic scaffolds for potential applications in bone tissue regeneration. To the Fuc-Gel we then incorporated the peptide sequence MTNYDEAAMAIASLN (MTN) derived from the E-F hand domain, known for its calcium binding properties. To mimic the components of the extracellular matrix of bone tissue, the Fuc-Gel-MTN assemblies were incubated in simulated body fluid (SBF) to induce biomineralization, resulting in the formation of β-tricalcium phosphate, and hydroxyapatite (HAp)...
September 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28880246/dental-composite-formulation-design-with-bioactivity-on-protein-adsorption-combined-with-crack-healing-capability
#9
Chen Chen, Junling Wu, Michael D Weir, Lin Wang, Xuedong Zhou, Hockin H K Xu, Mary Anne S Melo
Fracture and secondary caries are the primary reasons for the failure of dental restorations. To face this omnipresent problem, we report the formulation design and synthesis of a protein-resistant dental composite composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) that also can self-repair damage and recover the load-bearing capability via microencapsulated triethylene glycol dimethacrylate (TEGDMA) and N,N-dihydroxy ethyl-p-toluidine (DHEPT). The bioactivity of the resulting MPC-microencapsulated TEGDMA-DHEPT was evaluated on protein adsorption through early bacterial attachment...
September 7, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28872610/evaluation-of-polyethylene-glycol-diacrylate-polycaprolactone-scaffolds-for-tissue-engineering-applications
#10
Hari Kotturi, Alaeddin Abuabed, Haris Zafar, Elaine Sawyer, Bipin Pallipparambil, Harsha Jamadagni, Morshed Khandaker
Polyethylene Glycol Diacrylate (PEGDA) tissue scaffolds having a thickness higher than 1 mm and without the presence of nutrient conduit networks were shown to have limited applications in tissue engineering due to the inability of cells to adhere and migrate within the scaffold. The PEGDA scaffold has been coated with polycaprolactone (PCL) electrospun nanofiber (ENF) membrane on both sides to overcome these limitations, thereby creating a functional PEGDA-PCL scaffold. This study examined the physical, mechanical, and biological properties of the PEGDA and PEGDA-PCL scaffolds to determine the effect of PCL coating on PEGDA...
September 5, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28862647/bio-corrosion-of-magnesium-alloys-for-orthopaedic-applications
#11
Emily K Brooks, Mark T Ehrensberger
Three Mg alloys, Mg-1.34% Ca-3% Zn (MCZ), Mg-1.34% Ca-3% Zn-0.2% Sr (MCZS), and Mg-2% Sr (MS), were examined to understand their bio-corrosion behavior. Electrochemical impedance spectroscopy and polarization scans were performed after 6 days of immersion in cell culture medium, and ion release and changes in media pH were tracked over a 28 day time period. Scanning electron microscopy (SEM) of alloy microstructure was performed to help interpret the results of the electrochemical testing. Results indicate that corrosion resistance of the alloys is as follows: MCZ > MCZS > MS...
September 1, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28850069/sujiaonori-derived-algal-biomaterials-inhibit-allergic-reaction-in-allergen-sensitized-rbl-2h3-cell-line-and-improve-skin-health-in-humans
#12
Nlandu Roger Ngatu, Mamoru Tanaka, Mitsunori Ikeda, Masataka Inoue, Sakiko Kanbara, Sayumi Nojima
Sujiaonori, a river alga growing in the Kochi prefecture, Japan, contains several bioactive compounds such as sulfated polysaccharides (ulvans), ω-3 fatty acids, and vitamins. Dietary intake of this alga-based supplement has been reported to increase circulatory adiponectin, a salutary hormone that is reported to be associated with healthy longevity and prevents a number of cardiovascular and metabolic disorders. This report highlights the anti-allergic and skin health enhancing effects of Sujiaonori-derived ulvan (Tosalvan) and supplement, respectively...
August 29, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28832505/mn-2-znse-zns-sio%C3%A2-nanoparticles-for-turn-on-luminescence-thiol-detection
#13
Mohammad S Yazdanparast, William R Jeffries, Eric R Gray, Emily J McLaurin
Biological thiols are antioxidants essential for the prevention of disease. For example, low levels of the tripeptide glutathione are associated with heart disease, cancer, and dementia. Mn(2+)-doped wide bandgap semiconductor nanocrystals exhibit luminescence and magnetic properties that make them attractive for bimodal imaging. We found that these nanocrystals and silica-encapsulated nanoparticle derivatives exhibit enhanced luminescence in the presence of thiols in both organic solvent and aqueous solution...
August 23, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28805664/correlation-and-comparison-of-cortical-and-hippocampal-neural-progenitor-morphology-and-differentiation-through-the-use-of-micro-and-nano-topographies
#14
Sharvari Sathe, Xiang Quan Chan, Jing Jin, Erik Bernitt, Hans-Günther Döbereiner, Evelyn K F Yim
Neuronal morphology and differentiation have been extensively studied on topography. The differentiation potential of neural progenitors has been shown to be influenced by brain region, developmental stage, and time in culture. However, the neurogenecity and morphology of different neural progenitors in response to topography have not been quantitatively compared. In this study, the correlation between the morphology and differentiation of hippocampal and cortical neural progenitor cells was explored. The morphology of differentiated neural progenitors was quantified on an array of topographies...
August 12, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28792434/collective-migration-of-lens-epithelial-cell-induced-by-differential-microscale-groove-patterns
#15
Chunga Kwon, Youngjun Kim, Hojeong Jeon
Herein, a micro-patterned cell adhesive surface is prepared for the future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro patterns were prepared by a photolithography process. We investigated the effect of microscale topographical patterned surfaces on decreasing the collective cell migration rate. PDMS substrates were prepared through soft lithography using Si molds fabricated by photolithography. Afterwards, we observed the collective cell migration of human lens epithelial cells (B-3) on various groove/ridge patterns and evaluated the migration rate to determine the pattern most effective in slowing down the cell sheet spreading speed...
August 9, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28762999/immunological-responses-to-total-hip-arthroplasty
#16
REVIEW
Kenny Man, Lin-Hua Jiang, Richard Foster, Xuebin B Yang
The use of total hip arthroplasties (THA) has been continuously rising to meet the demands of the increasingly ageing population. To date, this procedure has been highly successful in relieving pain and restoring the functionality of patients' joints, and has significantly improved their quality of life. However, these implants are expected to eventually fail after 15-25 years in situ due to slow progressive inflammatory responses at the bone-implant interface. Such inflammatory responses are primarily mediated by immune cells such as macrophages, triggered by implant wear particles...
August 1, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28758949/potential-new-non-invasive-therapy-using-artificial-oxygen-carriers-for-pre-eclampsia
#17
REVIEW
Hidenobu Ohta, Maiko Kaga, Heng Li, Hiromi Sakai, Kunihiro Okamura, Nobuo Yaegashi
The molecular mechanisms of pre-eclampsia are being increasingly clarified in animals and humans. With the uncovering of these mechanisms, preventive therapy strategies using chronic infusion of adrenomedullin, vascular endothelial growth factor-121 (VEGF-121), losartan, and sildenafil have been proposed to block narrow spiral artery formation in the placenta by suppressing related possible factors for pre-eclampsia. However, although such preventive treatments have been partly successful, they have failed in ameliorating fetal growth restriction and carry the risk of possible side-effects of drugs on pregnant mothers...
July 30, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28758916/effect-of-a-particulate-and-a-putty-like-tricalcium-phosphate-based-bone-grafting-material-on-bone-formation-volume-stability-and-osteogenic-marker-expression-after-bilateral-sinus-floor-augmentation-in-humans
#18
Christine Knabe, Doaa Adel-Khattab, Esther Kluk, Rainer Struck, Michael Stiller
This study examines the effect of a hyaluronic acid (HyAc) containing tricalcium phosphate putty scaffold material (TCP-P) and of a particulate tricalcium phosphate (TCP-G) graft on bone formation, volume stability and osteogenic marker expression in biopsies sampled 6 months after bilateral sinus floor augmentation (SFA) in 7 patients applying a split-mouth design. 10% autogenous bone chips were added to the grafting material during surgery. The grain size of the TCP granules was 700 to 1400 µm for TCP-G and 125 to 250 µm and 500 to 700 µm (ratio 1:1) for TCP-P...
July 29, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28726761/a-cell-adhesive-plasma-polymerized-allylamine-coating-reduces-the-in-vivo-inflammatory-response-induced-by-ti6al4v-modified-with-plasma-immersion-ion-implantation-of-copper
#19
Uwe Walschus, Andreas Hoene, Maciej Patrzyk, Silke Lucke, Birgit Finke, Martin Polak, Gerold Lukowski, Rainer Bader, Carmen Zietz, Andreas Podbielski, J Barbara Nebe, Michael Schlosser
Copper (Cu) could be suitable to create anti-infective implants based on Titanium (Ti), for example by incorporating Cu into the implant surface using plasma immersion ion implantation (Cu-PIII). The cytotoxicity of Cu might be circumvented by an additional cell-adhesive plasma polymerized allylamine film (PPAAm). Thus, this study aimed to examine in vivo local inflammatory reactions for Ti6Al4V implants treated with Cu-PIII (Ti-Cu), alone or with an additional PPAAm film (Ti-Cu-PPAAm), compared to untreated implants (Ti)...
July 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28753925/pilot-study-using-a-chitosan-hydroxyapatite-implant-for-guided-alveolar-bone-growth-in-patients-with-chronic-periodontitis
#20
Fabiola Vaca-Cornejo, Héctor Macías Reyes, Sergio H Dueñas Jiménez, Ricardo A Llamas Velázquez, Judith M Dueñas Jiménez
Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis...
July 19, 2017: Journal of Functional Biomaterials
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