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Journal of Functional Biomaterials

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https://www.readbyqxmd.com/read/28880246/dental-composite-formulation-design-with-bioactivity-on-protein-adsorption-combined-with-crack-healing-capability
#1
Chen Chen, Junling Wu, Michael D Weir, Lin Wang, Xuedong Zhou, Hockin H K Xu, Mary Anne S Melo
Fracture and secondary caries are the primary reasons for the failure of dental restorations. To face this omnipresent problem, we report the formulation design and synthesis of a protein-resistant dental composite composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) that also can self-repair damage and recover the load-bearing capability via microencapsulated triethylene glycol dimethacrylate (TEGDMA) and N,N-dihydroxy ethyl-p-toluidine (DHEPT). The bioactivity of the resulting MPC-microencapsulated TEGDMA-DHEPT was evaluated on protein adsorption through early bacterial attachment...
September 7, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28872610/evaluation-of-polyethylene-glycol-diacrylate-polycaprolactone-scaffolds-for-tissue-engineering-applications
#2
Hari Kotturi, Alaeddin Abuabed, Haris Zafar, Elaine Sawyer, Bipin Pallipparambil, Harsha Jamadagni, Morshed Khandaker
Polyethylene Glycol Diacrylate (PEGDA) tissue scaffolds having a thickness higher than 1 mm and without the presence of nutrient conduit networks were shown to have limited applications in tissue engineering due to the inability of cells to adhere and migrate within the scaffold. The PEGDA scaffold has been coated with polycaprolactone (PCL) electrospun nanofiber (ENF) membrane on both sides to overcome these limitations, thereby creating a functional PEGDA-PCL scaffold. This study examined the physical, mechanical, and biological properties of the PEGDA and PEGDA-PCL scaffolds to determine the effect of PCL coating on PEGDA...
September 5, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28862647/bio-corrosion-of-magnesium-alloys-for-orthopaedic-applications
#3
Emily K Brooks, Mark T Ehrensberger
Three Mg alloys, Mg-1.34% Ca-3% Zn (MCZ), Mg-1.34% Ca-3% Zn-0.2% Sr (MCZS), and Mg-2% Sr (MS), were examined to understand their bio-corrosion behavior. Electrochemical impedance spectroscopy and polarization scans were performed after 6 days of immersion in cell culture medium, and ion release and changes in media pH were tracked over a 28 day time period. Scanning electron microscopy (SEM) of alloy microstructure was performed to help interpret the results of the electrochemical testing. Results indicate that corrosion resistance of the alloys is as follows: MCZ > MCZS > MS...
September 1, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28850069/sujiaonori-derived-algal-biomaterials-inhibit-allergic-reaction-in-allergen-sensitized-rbl-2h3-cell-line-and-improve-skin-health-in-humans
#4
Nlandu Roger Ngatu, Mamoru Tanaka, Mitsunori Ikeda, Masataka Inoue, Sakiko Kanbara, Sayumi Nojima
Sujiaonori, a river alga growing in the Kochi prefecture, Japan, contains several bioactive compounds such as sulfated polysaccharides (ulvans), ω-3 fatty acids, and vitamins. Dietary intake of this alga-based supplement has been reported to increase circulatory adiponectin, a salutary hormone that is reported to be associated with healthy longevity and prevents a number of cardiovascular and metabolic disorders. This report highlights the anti-allergic and skin health enhancing effects of Sujiaonori-derived ulvan (Tosalvan) and supplement, respectively...
August 29, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28832505/mn-2-znse-zns-sio%C3%A2-nanoparticles-for-turn-on-luminescence-thiol-detection
#5
Mohammad S Yazdanparast, William R Jeffries, Eric R Gray, Emily J McLaurin
Biological thiols are antioxidants essential for the prevention of disease. For example, low levels of the tripeptide glutathione are associated with heart disease, cancer, and dementia. Mn(2+)-doped wide bandgap semiconductor nanocrystals exhibit luminescence and magnetic properties that make them attractive for bimodal imaging. We found that these nanocrystals and silica-encapsulated nanoparticle derivatives exhibit enhanced luminescence in the presence of thiols in both organic solvent and aqueous solution...
August 23, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28805664/correlation-and-comparison-of-cortical-and-hippocampal-neural-progenitor-morphology-and-differentiation-through-the-use-of-micro-and-nano-topographies
#6
Sharvari Sathe, Xiang Quan Chan, Jing Jin, Erik Bernitt, Hans-Günther Döbereiner, Evelyn K F Yim
Neuronal morphology and differentiation have been extensively studied on topography. The differentiation potential of neural progenitors has been shown to be influenced by brain region, developmental stage, and time in culture. However, the neurogenecity and morphology of different neural progenitors in response to topography have not been quantitatively compared. In this study, the correlation between the morphology and differentiation of hippocampal and cortical neural progenitor cells was explored. The morphology of differentiated neural progenitors was quantified on an array of topographies...
August 12, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28792434/collective-migration-of-lens-epithelial-cell-induced-by-differential-microscale-groove-patterns
#7
Chunga Kwon, Youngjun Kim, Hojeong Jeon
Herein, a micro-patterned cell adhesive surface is prepared for the future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro patterns were prepared by a photolithography process. We investigated the effect of microscale topographical patterned surfaces on decreasing the collective cell migration rate. PDMS substrates were prepared through soft lithography using Si molds fabricated by photolithography. Afterwards, we observed the collective cell migration of human lens epithelial cells (B-3) on various groove/ridge patterns and evaluated the migration rate to determine the pattern most effective in slowing down the cell sheet spreading speed...
August 9, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28762999/immunological-responses-to-total-hip-arthroplasty
#8
REVIEW
Kenny Man, Lin-Hua Jiang, Richard Foster, Xuebin B Yang
The use of total hip arthroplasties (THA) has been continuously rising to meet the demands of the increasingly ageing population. To date, this procedure has been highly successful in relieving pain and restoring the functionality of patients' joints, and has significantly improved their quality of life. However, these implants are expected to eventually fail after 15-25 years in situ due to slow progressive inflammatory responses at the bone-implant interface. Such inflammatory responses are primarily mediated by immune cells such as macrophages, triggered by implant wear particles...
August 1, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28758949/potential-new-non-invasive-therapy-using-artificial-oxygen-carriers-for-pre-eclampsia
#9
REVIEW
Hidenobu Ohta, Maiko Kaga, Heng Li, Hiromi Sakai, Kunihiro Okamura, Nobuo Yaegashi
The molecular mechanisms of pre-eclampsia are being increasingly clarified in animals and humans. With the uncovering of these mechanisms, preventive therapy strategies using chronic infusion of adrenomedullin, vascular endothelial growth factor-121 (VEGF-121), losartan, and sildenafil have been proposed to block narrow spiral artery formation in the placenta by suppressing related possible factors for pre-eclampsia. However, although such preventive treatments have been partly successful, they have failed in ameliorating fetal growth restriction and carry the risk of possible side-effects of drugs on pregnant mothers...
July 30, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28758916/effect-of-a-particulate-and-a-putty-like-tricalcium-phosphate-based-bone-grafting-material-on-bone-formation-volume-stability-and-osteogenic-marker-expression-after-bilateral-sinus-floor-augmentation-in-humans
#10
Christine Knabe, Doaa Adel-Khattab, Esther Kluk, Rainer Struck, Michael Stiller
This study examines the effect of a hyaluronic acid (HyAc) containing tricalcium phosphate putty scaffold material (TCP-P) and of a particulate tricalcium phosphate (TCP-G) graft on bone formation, volume stability and osteogenic marker expression in biopsies sampled 6 months after bilateral sinus floor augmentation (SFA) in 7 patients applying a split-mouth design. 10% autogenous bone chips were added to the grafting material during surgery. The grain size of the TCP granules was 700 to 1400 µm for TCP-G and 125 to 250 µm and 500 to 700 µm (ratio 1:1) for TCP-P...
July 29, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28726761/a-cell-adhesive-plasma-polymerized-allylamine-coating-reduces-the-in-vivo-inflammatory-response-induced-by-ti6al4v-modified-with-plasma-immersion-ion-implantation-of-copper
#11
Uwe Walschus, Andreas Hoene, Maciej Patrzyk, Silke Lucke, Birgit Finke, Martin Polak, Gerold Lukowski, Rainer Bader, Carmen Zietz, Andreas Podbielski, J Barbara Nebe, Michael Schlosser
Copper (Cu) could be suitable to create anti-infective implants based on Titanium (Ti), for example by incorporating Cu into the implant surface using plasma immersion ion implantation (Cu-PIII). The cytotoxicity of Cu might be circumvented by an additional cell-adhesive plasma polymerized allylamine film (PPAAm). Thus, this study aimed to examine in vivo local inflammatory reactions for Ti6Al4V implants treated with Cu-PIII (Ti-Cu), alone or with an additional PPAAm film (Ti-Cu-PPAAm), compared to untreated implants (Ti)...
July 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28753925/pilot-study-using-a-chitosan-hydroxyapatite-implant-for-guided-alveolar-bone-growth-in-patients-with-chronic-periodontitis
#12
Fabiola Vaca-Cornejo, Héctor Macías Reyes, Sergio H Dueñas Jiménez, Ricardo A Llamas Velázquez, Judith M Dueñas Jiménez
Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis...
July 19, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28708123/the-feasibility-and-functional-performance-of-ternary-borate-filled-hydrophilic-bone-cements-targeting-therapeutic-release-thresholds-for-strontium
#13
Kathleen MacDonald, Richard B Price, Daniel Boyd
We examine the feasibility and functionality of hydrophilic modifications to a borate glass reinforced resin composite; with the objective of meeting and maintaining therapeutic thresholds for Sr release over time, as a potential method of incorporating antiosteoporotic therapy into a vertebroplasty material. Fifteen composites were formulated with the hydrophilic agent hydroxyl ethyl methacrylate (HEMA, 15, 22.5, 30, 37.5 or 45 wt% of resin phase) and filled with a borate glass (55, 60 or 65 wt% of total cement) with known Sr release characteristics...
July 14, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28686194/orthodontic-metallic-lingual-brackets-the-dark-side-of-the-moon-of-bond-failures
#14
Maria Francesca Sfondrini, Paola Gandini, Andrea Gioiella, Feng Xiao Zhou, Andrea Scribante
Lingual orthodontics, among both young and adult patients, increased in popularity during last years. The purposes of the present investigation were to evaluate the shear bond strength (SBS) values and Adhesive Remnant Index (ARI) scores of different lingual brackets compared with a vestibular control bracket. One hundred bovine teeth were extracted and embedded in resin blocks. Four different lingual brackets (Idea, Leone; STB, Ormco; TTR, RMO; 2D, Forestadent) and a vestibular control bracket (Victory, 3M) were bonded to the bovine enamel surfaces and subsequently shear tested to failure utilizing a Universal Testing Machine...
July 7, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28684672/color-stability-of-new-esthetic-restorative-materials-a-spectrophotometric-analysis
#15
Claudio Poggio, Lodovico Vialba, Anna Berardengo, Ricaldone Federico, Marco Colombo, Riccardo Beltrami, Andrea Scribante
The aim of this in vitro study was to evaluate and compare the color stability of different esthetic restorative materials (one microfilled composite, one nanofilled composite, one nanoceramic composite, one microfilled hybrid composite, one microfilled hybrid composite, one nanohybrid Ormocer based composite and one supra-nano spherical hybrid composite) after exposure to different staining solutions (physiological saline, red wine, coffee). All materials were prepared and polymerized into silicon rings (2 mm × 6 mm × 8 mm) to obtain specimens identical in size...
July 6, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28678157/an-injectable-glass-polyalkenoate-cement-engineered-for-fracture-fixation-and-stabilization
#16
Basel A Khader, Sean A F Peel, Mark R Towler
Glass polyalkenoate cements (GPCs) have potential as bio-adhesives due to their ease of application, appropriate mechanical properties, radiopacity and chemical adhesion to bone. Aluminium (Al)-free GPCs have been discussed in the literature, but have proven difficult to balance injectability with mechanical integrity. For example, zinc-based, Al-free GPCs reported compressive strengths of 63 MPa, but set in under 2 min. Here, the authors design injectable GPCs (IGPCs) based on zinc-containing, Al-free silicate compositions containing GeO₂, substituted for ZnO at 3% increments through the series...
July 5, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28657582/biocompatibility-of-hbv-liposome-encapsulated-hemoglobin-molecules-liposome-effects-on-immune-function
#17
REVIEW
Hiroshi Azuma, Mitsuhiro Fujihara, Hiromi Sakai
Hemoglobin vesicles (HbVs) are oxygen carriers consisting of Hb molecules and liposome in which human hemoglobin (Hb) molecules are encapsulated. Investigations of HbV biocompatibility have shown that HbVs have no significant effect on either the quality or quantity of blood components such as RBC, WBC, platelets, complements, or coagulation factors, reflecting its excellent biocompatibility. However, their effects on the immune system remain to be evaluated. HbVs might affect the function of macrophages because they accumulate in the reticuloendothelial system...
June 28, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28672849/synergy-of-iron-chelators-and-therapeutic-peptide-sequences-delivered-via-a-magnetic-nanocarrier
#18
Gayani S Abayaweera, Hongwang Wang, Tej B Shrestha, Jing Yu, Kyle Angle, Prem Thapa, Aruni P Malalasekera, Leila Maurmann, Deryl L Troyer, Stefan H Bossmann
Here, we report the synthesis, characterization, and efficacy study of Fe/Fe₃O₄-nanoparticles that were co-labeled with a tumor-homing and membrane-disrupting oligopeptide and the iron-chelator Dp44mT, which belongs to the group of the thiosemicarbazones. Dp44mT and the peptide sequence PLFAERL(D[KLAKLAKKLAKLAK])CGKRK were tethered to the surface of Fe/Fe₃O₄ core/shell nanoparticles by utilizing dopamine-anchors. The 26-mer contains two important sequences, which are the tumor targeting peptide CGKRK, and D[KLAKLAK]₂, known to disrupt the mitochondrial cell walls and to initiate programmed cell death (apoptosis)...
June 26, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28644382/metal-ion-loaded-nanofibre-matrices-for-calcification-inhibition-in-polyurethane-implants
#19
Charanpreet Singh, Xungai Wang
Pathologic calcification leads to structural deterioration of implant materials via stiffening, stress cracking, and other structural disintegration mechanisms, and the effect can be critical for implants intended for long-term or permanent implantation. This study demonstrates the potential of using specific metal ions (MI)s for inhibiting pathological calcification in polyurethane (PU) implants. The hypothesis of using MIs as anti-calcification agents was based on the natural calcium-antagonist role of Mg(2+) ions in human body, and the anti-calcification effect of Fe(3+) ions in bio-prosthetic heart valves has previously been confirmed...
June 23, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28640198/experimental-investigation-of-magnetic-nanoparticle-enhanced-microwave-hyperthermia
#20
Brogan T McWilliams, Hongwang Wang, Valerie J Binns, Sergio Curto, Stefan H Bossmann, Punit Prakash
The objective of this study was to evaluate microwave heating enhancements offered by iron/iron oxide nanoparticles dispersed within tissue-mimicking media for improving efficacy of microwave thermal therapy. The following dopamine-coated magnetic nanoparticles (MNPs) were considered: 10 and 20 nm diameter spherical core/shell Fe/Fe₃O₄, 20 nm edge-length cubic Fe₃O₄, and 45 nm edge-length/10 nm height hexagonal Fe₃O₄. Microwave heating enhancements were experimentally measured with MNPs dissolved in an agar phantom, placed within a rectangular waveguide...
June 22, 2017: Journal of Functional Biomaterials
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