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Journal of Functional Biomaterials

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https://www.readbyqxmd.com/read/27916951/silica-based-and-borate-based-titania-containing-bioactive-coatings-characterization-critical-strain-energy-release-rate-residual-stresses-hardness-and-thermal-expansion
#1
Omar Rodriguez, Ali Matinmanesh, Sunjeev Phull, Emil H Schemitsch, Paul Zalzal, Owen M Clarkin, Marcello Papini, Mark R Towler
Silica-based and borate-based glass series, with increasing amounts of TiO₂ incorporated, are characterized in terms of their mechanical properties relevant to their use as metallic coating materials. It is observed that borate-based glasses exhibit CTE (Coefficient of Thermal Expansion) closer to the substrate's (Ti6Al4V) CTE, translating into higher mode I critical strain energy release rates of glasses and compressive residual stresses and strains at the coating/substrate interface, outperforming the silica-based glasses counterparts...
December 1, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27916868/characterization-and-schwann-cell-seeding-of-up-to-15-0-cm-long-spider-silk-nerve-conduits-for-reconstruction-of-peripheral-nerve-defects
#2
Tim Kornfeld, Peter M Vogt, Vesna Bucan, Claas-Tido Peck, Kerstin Reimers, Christine Radtke
Nerve reconstruction of extended nerve defect injuries still remains challenging with respect to therapeutic options. The gold standard in nerve surgery is the autologous nerve graft. Due to the limitation of adequate donor nerves, surgical alternatives are needed. Nerve grafts made out of either natural or artificial materials represent this alternative. Several biomaterials are being explored and preclinical and clinical applications are ongoing. Unfortunately, nerve conduits with successful enhancement of axonal regeneration for nerve defects measuring over 4...
November 30, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27916829/in-vitro-study-of-a-superhydrophilic-thin-film-nitinol-endograft-that-is-electrostatically-endothelialized-in-the-catheter-prior-to-the-endovascular-procedure
#3
Mahdis Shayan, Yanfei Chen, Puneeth Shridhar, Colin P Kealey, YoungJae Chun
Electrostatic endothelial cell seeding has evolved as an exceptional technique to improve the efficiency of cell seeding in terms of frequency of attached cells and the amount of cell adhesion for the treatment of vascular diseases. In the recent times, both untreated and superhydrophilic thin film nitinol (TFN) have exhibited strong prospects as substrates for creation of small-diameter endovascular grafts due to their hallmark properties of superelasticity, ultra low-profile character, and grown hemocompatible oxide layer with the presence of a uniform endothelial layer on the surface...
November 29, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27869709/cerebral-microvascular-and-systemic-effects-following-intravenous-administration-of-the-perfluorocarbon-emulsion-perftoran
#4
Rania Abutarboush, Biswajit K Saha, Saad H Mullah, Francoise G Arnaud, Ashraful Haque, Chioma Aligbe, Georgina Pappas, Charles R Auker, Richard M McCarron, Paula F Moon-Massat, Anke H Scultetus
Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects...
November 18, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27763503/debris-evaluation-after-root-canal-shaping-with-rotating-and-reciprocating-single-file-systems
#5
Alberto Dagna, Giulia Gastaldo, Riccardo Beltrami, Claudio Poggio
This study evaluated the root canal dentine surface by scanning electron microscope (SEM) after shaping with two reciprocating single-file NiTi systems and two rotating single-file NiTi systems, in order to verify the presence/absence of the smear layer and the presence/absence of open tubules along the walls of each sample; Forty-eight single-rooted teeth were divided into four groups and shaped with OneShape (OS), F6 SkyTaper (F6), WaveOne (WO) and Reciproc and irrigated using 5.25% NaOCl and 17% EDTA. Root canal walls were analyzed by SEM at a standard magnification of 2500×...
October 17, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27649252/synthesis-and-characterization-of-nanodiamond-reinforced-chitosan-for-bone-tissue-engineering
#6
Yu Sun, Qiaoqin Yang, Haidong Wang
Multifunctional tissue scaffold material nanodiamond (ND)/chitosan (CS) composites with different diamond concentrations from 1 wt % to 5 wt % were synthesized through a solution casting method. The microstructure and mechanical properties of the composites were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and nanoindentation. Compared with pristine CS, the addition of ND resulted in a significant improvement of mechanical properties, including a 239%, 276%, 321%, 333%, and 343% increase in Young's modulus and a 68%, 96%, 114%, 118%, and 127% increase in hardness when the ND amount was 1 wt %, 2 wt %, 3 wt %, 4 wt %, and 5 wt %, respectively...
September 15, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27649251/processing-techniques-and-applications-of-silk-hydrogels-in-bioengineering
#7
REVIEW
Michael Floren, Claudio Migliaresi, Antonella Motta
Hydrogels are an attractive class of tunable material platforms that, combined with their structural and functional likeness to biological environments, have a diversity of applications in bioengineering. Several polymers, natural and synthetic, can be used, the material selection being based on the required functional characteristics of the prepared hydrogels. Silk fibroin (SF) is an attractive natural polymer for its excellent processability, biocompatibility, controlled degradation, mechanical properties and tunable formats and a good candidate for the fabrication of hydrogels...
September 14, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27626452/a-smart-ph-responsive-three-components-luminescent-hydrogel
#8
Yibao Li, Wei Liu, Linxiu Cheng, Ping Huang, Yu Peng, Yongquan Wu, Xun Li, Xiaokang Li, Xiaolin Fan
In this study, we report a novel three-component luminescent hydrogel, which is composed of amino acid derivatives (N,N'-di valine-3,4,9,10-perylenetetracarboxylic acid, NVPD), riboflavin (RF), and melamine (MM). The three-component hydrogel is attributed to multiple hydrogen bonds and the strong π-π stacking interaction between these molecules. Based on the strong hydrogen bonding of the gelator, when the reversible process between the gel and the solution take places it changes the pH of the system from 6...
September 12, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27626451/photocrosslinkable-trehalose-derivatives-carrying-mesogenic-groups-synthesis-characterization-and-in-vitro-evaluation-for-fibroblast-attachment
#9
Shinya Yano, Naozumi Teramoto, Toshiaki Shimasaki, Mitsuhiro Shibata
A photocrosslinkable trehalose derivative carrying mesogenic groups was synthesized by esterification reactions. The derivative (TC-HBPHA) was synthesized by the reaction of partially cinnamoyl-modified trehalose (TC4) with 4-(4-hexyloxybenzoyloxy)phenoxy-6-oxohexanoic acid (HBPHA) as a mesogenic unit. TC-HBPHA showed a nematic liquid crystalline mesophase at a temperature range from 150 °C to 175 °C in the heating process under observation with a polarized optical microscope. The dimerization of the cinnamoyl groups of TC-HBPHA by ultraviolet (UV) light irradiation was monitored by ultraviolet-visible (UV-Vis) spectroscopy and Fourier transform infrared (FT-IR) spectroscopy...
September 10, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27618911/real-time-protein-and-cell-binding-measurements-on-hydroxyapatite-coatings
#10
A M Vilardell, N Cinca, A Jokinen, N Garcia-Giralt, S Dosta, I G Cano, J M Guilemany
Although a lot of in vitro and in vivo assays have been performed during the last few decades years for hydroxyapatite bioactive coatings, there is a lack of exploitation of real-time in vitro interaction measurements. In the present work, real-time interactions for a plasma sprayed hydroxyapatite coating were measured by a Multi-Parametric Surface Plasmon Resonance (MP-SPR), and the results were compared with standard traditional cell viability in vitro assays. MP-SPR is proven to be suitable not only for measurement of molecule-molecule interactions but also molecule-material interaction measurements and cell interaction...
August 27, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27527229/tissue-regeneration-a-silk-road
#11
REVIEW
Dave Jao, Xiaoyang Mou, Xiao Hu
Silk proteins are natural biopolymers that have extensive structural possibilities for chemical and mechanical modifications to facilitate novel properties, functions, and applications in the biomedical field. The versatile processability of silk fibroins (SF) into different forms such as gels, films, foams, membranes, scaffolds, and nanofibers makes it appealing in a variety of applications that require mechanically superior, biocompatible, biodegradable, and functionalizable biomaterials. There is no doubt that nature is the world's best biological engineer, with simple, exquisite but powerful designs that have inspired novel technologies...
August 5, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27490577/ph-responsive-plga-nanoparticle-for-controlled-payload-delivery-of-diclofenac-sodium
#12
Shalil Khanal, Udhab Adhikari, Nava P Rijal, Shanta R Bhattarai, Jagannathan Sankar, Narayan Bhattarai
Poly(lactic-co-glycolic acid) (PLGA) based nanoparticles have gained increasing attention in delivery applications due to their capability for controlled drug release characteristics, biocompatibility, and tunable mechanical, as well as degradation, properties. However, thorough study is always required while evaluating potential toxicity of the particles from dose dumping, inconsistent release and drug-polymer interactions. In this research, we developed PLGA nanoparticles modified by chitosan (CS), a cationic and pH responsive polysaccharide that bears repetitive amine groups in its backbone...
August 2, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27472374/in-response-to-michael-wininger-s-commentary-common-roadblocks-for-biomaterials-metrologists
#13
Andrew Naylor
I welcome Wininger's commentary [1], and I would like to take the opportunity to address some of the issues raised.[...].
July 27, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27455336/stimuli-responsive-gold-nanoparticles-for-cancer-diagnosis-and-therapy
#14
REVIEW
Li Tian, Linfeng Lu, Yang Qiao, Saisree Ravi, Ferandre Salatan, Marites P Melancon
An emerging concept is that cancers strongly depend on both internal and external signals for growth and invasion. In this review, we will discuss pathological and physical changes in the tumor microenvironment and how these changes can be exploited to design gold nanoparticles for cancer diagnosis and therapy. These intrinsic changes include extracellular and intracellular pH, extracellular matrix enzymes, and glutathione concentration. External stimuli include the application of laser, ultrasound and X-ray...
2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27420104/effect-of-nanoparticle-incorporation-and-surface-coating-on-mechanical-properties-of-bone-scaffolds-a-brief-review
#15
REVIEW
Jesus Corona-Gomez, Xiongbiao Chen, Qiaoqin Yang
Mechanical properties of a scaffold play an important role in its in vivo performance in bone tissue engineering, due to the fact that implanted scaffolds are typically subjected to stress including compression, tension, torsion, and shearing. Unfortunately, not all the materials used to fabricate scaffolds are strong enough to mimic native bones. Extensive research has been conducted in order to increase scaffold strength and mechanical performance by incorporating nanoparticles and/or coatings. An incredible improvement has been achieved; and some outstanding examples are the usage of nanodiamond, hydroxyapatite, bioactive glass particles, SiO₂, MgO, and silver nanoparticles...
2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27399789/synchrotron-based-in-situ-characterization-of-the-scaffold-mass-loss-from-erosion-degradation
#16
Nahshon K Bawolin, Xiongbaio Chen
The mass loss behavior of degradable tissue scaffolds is critical to their lifespan and other degradation-related properties including mechanical strength and mass transport characteristics. This paper presents a novel method based on synchrotron imaging to characterize the scaffold mass loss from erosion degradation in situ, or without the need of extracting scaffolds once implanted. Specifically, the surface-eroding degradation of scaffolds in a degrading medium was monitored in situ by synchrotron-based imaging; and the time-dependent geometry of scaffolds captured by images was then employed to estimate their mass loss with time, based on the mathematical model that was adopted from the literature of surface erosion with the experimentally-identified model parameters...
2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27367737/a-review-of-glass-ionomer-cements-for-clinical-dentistry
#17
REVIEW
Sharanbir K Sidhu, John W Nicholson
This article is an updated review of the published literature on glass-ionomer cements and covers their structure, properties and clinical uses within dentistry, with an emphasis on findings from the last five years or so. Glass-ionomers are shown to set by an acid-base reaction within 2-3 min and to form hard, reasonably strong materials with acceptable appearance. They release fluoride and are bioactive, so that they gradually develop a strong, durable interfacial ion-exchange layer at the interface with the tooth, which is responsible for their adhesion...
2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27314395/fibrochondrocyte-growth-and-functionality-on-tio%C3%A2-nanothin-films
#18
Sharon Ronald, David K Mills
Disorders affecting the temporomandibular joint (TMJ) are a long-standing health concern. TMJ disorders (TMJD) are often associated with an internal disc derangement accompanied by a suite of symptoms including joint noises, jaw dysfunction, and severe pain. The severity of patient symptoms and their reoccurrence can be alleviated to some extent with conservative therapy; however, refractory cases often require surgery that has shown only limited success. Bioengineered scaffolds with cell supportive surfaces an d nanoarchitectures that mimic TMJ tissue structure may offer an alternative treatment modality...
2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27271675/characterization-of-tensile-mechanical-behavior-of-mscs-plcl-hybrid-layered-sheet
#19
Azizah Intan Pangesty, Takaaki Arahira, Mitsugu Todo
A layered construct was developed by combining a porous polymer sheet and a cell sheet as a tissue engineered vascular patch. The primary objective of this study is to investigate the influence of mesenchymal stem cells (MSCs) sheet on the tensile mechanical properties of porous poly-(l-lactide-co-ε-caprolactone) (PLCL) sheet. The porous PLCL sheet was fabricated by the solid-liquid phase separation method and the following freeze-drying method. The MSCs sheet, prepared by the temperature-responsive dish, was then layered on the top of the PLCL sheet and cultured for 2 weeks...
2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27213461/keratoprosthesis-a-review-of-recent-advances-in-the-field
#20
REVIEW
Borja Salvador-Culla, Paraskevi E Kolovou
Since its discovery in the years of the French Revolution, the field of keratoprostheses has evolved significantly. However, the path towards its present state has not always been an easy one. Initially discarded for its devastating complications, the introduction of new materials and the discovery of antibiotics in the last century gave new life to the field. Since then, the use of keratoprostheses for severe ocular surface disorders and corneal opacities has increased significantly, to the point that it has become a standard procedure for corneal specialists worldwide...
2016: Journal of Functional Biomaterials
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