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Journal of Functional Biomaterials

Daniel N Bracey, Thorsten M Seyler, Alexander H Jinnah, Mark O Lively, Jeffrey S Willey, Thomas L Smith, Mark E Van Dyke, Patrick W Whitlock
BACKGROUND: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but is limited in supply and its harvest imparts significant morbidity to the patient. Alternative sources of bone graft include allografts, synthetics and, less commonly, xenografts which are taken from animal species. Xenografts are available in unlimited supply from healthy animal donors with controlled biology, avoiding the risk of human disease transmission, and may satisfy current demand for bone graft products...
July 12, 2018: Journal of Functional Biomaterials
Ortensia Ilaria Parisi, Luca Scrivano, Fabio Amone, Rocco Malivindi, Mariarosa Ruffo, Anna Francesca Vattimo, Vincenzo Pezzi, Francesco Puoci
Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel anti-baldness agent based on Interconnected PolymerS TeChnology (IPSTiC), which is an effective strategy for the delivery of bioactive molecules, was developed. This product (IPSTiC patch hair) is based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins and is able to improve efficacy and stability of bioactive ingredients such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract...
July 12, 2018: Journal of Functional Biomaterials
Jennifer Gansau, Conor Timothy Buckley
Hydrogels, such as fibrin, offer a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to regenerate damaged disc tissue as a potential treatment for low back pain. However, fibrin lacks key extracellular matrix (ECM) components, such as collagen (Col) and hyaluronan (HA), normally found in native nucleus pulposus (NP) tissue. The overall aim of this work was to create a fibrin-based hydrogel, by incorporating Col and HA into the matrix to enhance NP-like matrix accumulation using articular chondrocytes (CC)...
July 10, 2018: Journal of Functional Biomaterials
Nikolaos-Stefanos Kampanas, Maria Antoniadou
BACKGROUND: The restoration of non-carious cervical lesions in geriatric patients is a demanding process. Glass ionomer cements can be promising materials for the management of these lesions in older adults. The aim of this literature review is to present the benefits of glass ionomers and how they can be used for the restoration of non-carious cervical lesions of older adults depending on the geriatric patient's profile. DATA SOURCES: All available in vitro and in vivo studies from Google Scholar, PubMed and Scopus search engines corresponding to glass ionomer cements, geriatric dentistry, elderly patients, and non-carious lesions as key words were reviewed...
July 8, 2018: Journal of Functional Biomaterials
Jan Sher Akmal, Mika Salmi, Antti Mäkitie, Roy Björkstrand, Jouni Partanen
The purpose of this study is to demonstrate the ability of additive manufacturing, also known as 3D printing, to produce effective drug delivery devices and implants that are both identifiable, as well as traceable. Drug delivery devices can potentially be used for drug release in the direct vicinity of target tissues or the selected medication route in a patient-specific manner as required. The identification and traceability of additively manufactured implants can be administered through radiofrequency identification systems...
June 29, 2018: Journal of Functional Biomaterials
Daniela A Frauchiger, Rahel D May, Ezgi Bakirci, Adel Tekari, Samantha C W Chan, Michael Wöltje, Lorin M Benneker, Benjamin Gantenbein
(1) Background: Intervertebral disc (IVD) repair represents a major challenge. Using functionalised biomaterials such as silk combined with enforced hydrogels might be a promising approach for disc repair. We aimed to test an IVD repair approach by combining a genipin-enhanced fibrin hydrogel with an engineered silk scaffold under complex load, after inducing an injury in a bovine whole organ IVD culture; (2) Methods: Bovine coccygeal IVDs were isolated from ~1-year-old animals within four hours post-mortem...
June 24, 2018: Journal of Functional Biomaterials
Melissa J Black, Adam A Lucero, Philip W Fink, Lee Stoner, Sarah P Shultz, Sally D Lark, David S Rowlands
The increased risk of falls associated with advancing age has increased demand for methods to improve balance and mobility. The primary purpose of the study was to determine whether wearing Aqua Titan-treated stockings could improve balance and walking performance in an older population; secondary was to elucidate the mechanisms. In a randomized, double-blind crossover, 16 healthy older adults (age, 67.9 ± 4.2 years; BMI, 24.8 ± 3.1 kg/m²) performed two 4-day trials composed of baseline measures and fatiguing exercise on Day 1, with recovery measures at 14, 38 and 62 h post-exercise, wearing Aqua Titan and control stockings...
June 8, 2018: Journal of Functional Biomaterials
Kazuo Azuma, Ryotaro Izumi, Tomohiro Osaki, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki Saimoto, Saburo Minami, Yoshiharu Okamoto
The Journal of Functional Biomaterials Editorial Office have been made aware that some parts of the article [1] are duplicated from other publications[...].
June 7, 2018: Journal of Functional Biomaterials
Giacomo D'Angelo, Amal Elhussieny, Marwa Faisal, I S Fahim, Nicola M Everitt
The use of biodegradable materials for shopping bag production, and other products made from plastics, has recently been an object of intense research-with the aim of reducing the environmental burdens given by conventional materials. Chitosan is a potential material because of its biocompatibility, degradability, and non-toxicity. It is a semi-natural biopolymeric material produced by the deacetylation of chitin, which is the second most abundant natural biopolymer (after cellulose). Chitin is found in the exoskeleton of insects, marine crustaceans, and the cell walls of certain fungi and algae...
May 22, 2018: Journal of Functional Biomaterials
Wan Khartini Wan Abdul Khodir, Abdul Hakim Abdul Razak, Min Hwei Ng, Vincenzo Guarino, Deny Susanti
In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment...
May 18, 2018: Journal of Functional Biomaterials
Timur Sh Atabaev, Zhonglie Piao, Anara Molkenova
In recent years, functional nanoprobes with multiple imaging modalities have become an emerging field of biomedical research. In this preliminary study, we utilized a facile hydrothermal method for the preparation of magneto-fluorescent bimodal carbon dots doped with dysprosium (Dy-CDs). The prepared Dy-CDs have shown a good colloidal stability in a water solution and strong blue⁻green fluorescence, with a maximum at 452 nm. In addition, the excellent transverse relaxivity of the prepared Dy-CDs (r₂ = 7...
May 18, 2018: Journal of Functional Biomaterials
Simona Martinotti, Elia Ranzato
Honey possesses anti-bacterial, anti-inflammatory and other properties that are useful for wound healing and tissue regeneration. Furthermore, honey has been used for millennia in folk medicine. The misuse of antibiotics has again boosted the use of honey in regenerative medicine. The multifaceted properties of honey could possibly be exploited for scaffold applications in tissue healing.
May 8, 2018: Journal of Functional Biomaterials
Achmad Dzihan Shaghiera, Prihartini Widiyanti, Helmy Yusuf
Thirty percent of global mortalities are caused by cardiovascular disease, and 54% of the aforementioned amount is instigated by ischemic heart disease that triggered myocardial infarction. Myocardial infarction is due to blood flow cessation in certain coronary arteries that causes lack of oxygen (ischemia) and stimulates myocardial necrosis. One of the methods to treat myocardial infarction consists in injecting cells or active biomolecules and biomaterials into heart infarction locations. This study aimed to investigate the characteristics of a collagen⁻chitosan-based hydrogel with variations in its chitosan composition...
April 30, 2018: Journal of Functional Biomaterials
Iffa A Fiqrianti, Prihartini Widiyanti, Muhammad A Manaf, Claudia Y Savira, Nadia R Cahyani, Fitria R Bella
Poly-L-Lactic acid (PLLA) blended with chitosan and collagen was used to fabricate a conduit for blood vessel engineering through an electrospinning process. Various concentrations of chitosan were used in the blend in order to study its effect on the morphology, chemical bond, tensile strength, burst pressure, hemocompatibility, and cell viability (cytotoxicity) of the tube.In vitro assessments indicated that addition of chitosan-collagen could improve cell viability and hemocompatibility. Best results were demonstrated by the conduit with 10% PLLA, 0...
April 30, 2018: Journal of Functional Biomaterials
Pouya Saeedi, Amin Shavandi, Kim Meredith-Jones
Physicochemical properties of nail may offer valuable insight into the health of bone. Currently, dual-energy X-ray absorptiometry (DXA) is the gold standard technique for evaluating bone health through bone mineral density (BMD). However, only 70% of fractures are explained by low BMD according to DXA. Therefore, the World Health Organisation recommended the need for the development of alternative methods of assessing bone health. Keratin and collagen type I are major proteins in nail and bone, respectively...
April 23, 2018: Journal of Functional Biomaterials
Kyle J Lynch, Omar Skalli, Firouzeh Sabri
Externally applied electrical stimulation (ES) has been shown to enhance the nerve regeneration process and to influence the directionality of neurite outgrowth. In addition, the physical and chemical properties of the substrate used for nerve-cell regeneration is critical in fostering regeneration. Previously, we have shown that polyurea-crosslinked silica aerogels (PCSA) exert a positive influence on the extension of neurites by PC-12 cells, a cell-line model widely used to study neurite extension and electrical excitability...
April 20, 2018: Journal of Functional Biomaterials
Gina Quiram, Francisco Montagner, Kelli L Palmer, Mihaela C Stefan, Katherine E Washington, Danieli C Rodrigues
Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs...
April 17, 2018: Journal of Functional Biomaterials
Omar Rodriguez, Adel Alhalawani, Saad Arshad, Mark R Towler
A novel bioactive glass series containing incremental amounts of silver oxide was synthesized, ground down, and subsequently incorporated into a dentifrice for the purpose of reducing the incidence of dental caries and lesion formation. Three glasses were synthesized using the melt quench route: Si-Control (70SiO₂-12CaO-3P₂O₅-15Na₂O, mol %), Si-02 and Si-05, where 0.2 and 0.5 mol % Ag₂O were substituted, respectively, for SiO₂ in Si-Control. The glasses were then ground, sieved, characterized, and dissolved in Tris buffer solution (pH = 7...
April 11, 2018: Journal of Functional Biomaterials
Marica Marrese, Valentina Cirillo, Vincenzo Guarino, Luigi Ambrosio
Electrospun polymeric fibers are currently used as 3D models for in vitro applications in biomedical areas, i.e., tissue engineering, cell and drug delivery. The high customization of the electrospinning process offers numerous opportunities to manipulate and control surface area, fiber diameter, and fiber density to evaluate the response of cells under different morphological and/or biochemical stimuli. The aim of this study was to investigate-via atomic force microscopy (AFM)-the chemical and morphological changes in bi-component electrospun fibers (BEFs) during the in vitro degradation process using a biological medium...
March 30, 2018: Journal of Functional Biomaterials
W C Mak, K Olesen, P Sivlér, C J Lee, I Moreno-Jimenez, J Edin, D Courtman, M Skog, M Griffith
Recently, we found a mistake in Figure 4D in our previously published paper[...].
March 21, 2018: Journal of Functional Biomaterials
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