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Journal of Functional Biomaterials

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https://www.readbyqxmd.com/read/29786635/mechanical-behavior-optimization-of-chitosan-extracted-from-shrimp-shells-as-a-sustainable-material-for-shopping-bags
#1
Giacomo D'Angelo, Amal Elhussieny, Marwa Faisal, I S Fahim, Nicola M Everitt
The use of biodegradable materials for shopping bag production, and other products made from plastics, has recently been an object of intense research-with the aim of reducing the environmental burdens given by conventional materials. Chitosan is a potential material because of its biocompatibility, degradability, and non-toxicity. It is a semi-natural biopolymeric material produced by the deacetylation of chitin, which is the second most abundant natural biopolymer (after cellulose). Chitin is found in the exoskeleton of insects, marine crustaceans, and the cell walls of certain fungi and algae...
May 22, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29783681/encapsulation-and-characterization-of-gentamicin-sulfate-in-the-collagen-added-electrospun-nanofibers-for-skin-regeneration
#2
Wan Khartini Wan Abdul Khodir, Abdul Hakim Abdul Razak, Min Hwei Ng, Vincenzo Guarino, Deny Susanti
In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment...
May 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29783645/carbon-dots-doped-with-dysprosium-a-bimodal-nanoprobe-for-mri-and-fluorescence-imaging
#3
Timur Sh Atabaev, Zhonglie Piao, Anara Molkenova
In recent years, functional nanoprobes with multiple imaging modalities have become an emerging field of biomedical research. In this preliminary study, we utilized a facile hydrothermal method for the preparation of magneto-fluorescent bimodal carbon dots doped with dysprosium (Dy-CDs). The prepared Dy-CDs have shown a good colloidal stability in a water solution and strong blue⁻green fluorescence, with a maximum at 452 nm. In addition, the excellent transverse relaxivity of the prepared Dy-CDs (r₂ = 7...
May 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29738478/honey-wound-repair-and-regenerative-medicine
#4
REVIEW
Simona Martinotti, Elia Ranzato
Honey possesses anti-bacterial, anti-inflammatory and other properties that are useful for wound healing and tissue regeneration. Furthermore, honey has been used for millennia in folk medicine. The misuse of antibiotics has again boosted the use of honey in regenerative medicine. The multifaceted properties of honey could possibly be exploited for scaffold applications in tissue healing.
May 8, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29710844/synthesis-and-characterization-of-injectable-hydrogels-with-varying-collagen%C3%A2-chitosan%C3%A2-thymosin-%C3%AE-4-composition-for-myocardial-infarction-therapy
#5
Achmad Dzihan Shaghiera, Prihartini Widiyanti, Helmy Yusuf
Thirty percent of global mortalities are caused by cardiovascular disease, and 54% of the aforementioned amount is instigated by ischemic heart disease that triggered myocardial infarction. Myocardial infarction is due to blood flow cessation in certain coronary arteries that causes lack of oxygen (ischemia) and stimulates myocardial necrosis. One of the methods to treat myocardial infarction consists in injecting cells or active biomolecules and biomaterials into heart infarction locations. This study aimed to investigate the characteristics of a collagen⁻chitosan-based hydrogel with variations in its chitosan composition...
April 30, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29710843/poly-l-lactic-acid-plla-chitosan-collagen-electrospun-tube-for-vascular-graft-application
#6
Iffa A Fiqrianti, Prihartini Widiyanti, Muhammad A Manaf, Claudia Y Savira, Nadia R Cahyani, Fitria R Bella
Poly-L-Lactic acid (PLLA) blended with chitosan and collagen was used to fabricate a conduit for blood vessel engineering through an electrospinning process. Various concentrations of chitosan were used in the blend in order to study its effect on the morphology, chemical bond, tensile strength, burst pressure, hemocompatibility, and cell viability (cytotoxicity) of the tube.In vitro assessments indicated that addition of chitosan-collagen could improve cell viability and hemocompatibility. Best results were demonstrated by the conduit with 10% PLLA, 0...
April 30, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29690604/nail-properties-and-bone-health-a-review
#7
REVIEW
Pouya Saeedi, Amin Shavandi, Kim Meredith-Jones
Physicochemical properties of nail may offer valuable insight into the health of bone. Currently, dual-energy X-ray absorptiometry (DXA) is the gold standard technique for evaluating bone health through bone mineral density (BMD). However, only 70% of fractures are explained by low BMD according to DXA. Therefore, the World Health Organisation recommended the need for the development of alternative methods of assessing bone health. Keratin and collagen type I are major proteins in nail and bone, respectively...
April 23, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29677113/growing-neural-pc-12-cell-on-crosslinked-silica-aerogels-increases-neurite-extension-in-the-presence-of-an-electric-field
#8
Kyle J Lynch, Omar Skalli, Firouzeh Sabri
Externally applied electrical stimulation (ES) has been shown to enhance the nerve regeneration process and to influence the directionality of neurite outgrowth. In addition, the physical and chemical properties of the substrate used for nerve-cell regeneration is critical in fostering regeneration. Previously, we have shown that polyurea-crosslinked silica aerogels (PCSA) exert a positive influence on the extension of neurites by PC-12 cells, a cell-line model widely used to study neurite extension and electrical excitability...
April 20, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29673188/novel-chlorhexidine-loaded-polymeric-nanoparticles-for-root-canal-treatment
#9
Gina Quiram, Francisco Montagner, Kelli L Palmer, Mihaela C Stefan, Katherine E Washington, Danieli C Rodrigues
Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs...
April 17, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29641491/rapidly-dissolving-silver-containing-bioactive-glasses-for-cariostatic-applications
#10
Omar Rodriguez, Adel Alhalawani, Saad Arshad, Mark R Towler
A novel bioactive glass series containing incremental amounts of silver oxide was synthesized, ground down, and subsequently incorporated into a dentifrice for the purpose of reducing the incidence of dental caries and lesion formation. Three glasses were synthesized using the melt quench route: Si-Control (70SiO₂-12CaO-3P₂O₅-15Na₂O, mol %), Si-02 and Si-05, where 0.2 and 0.5 mol % Ag₂O were substituted, respectively, for SiO₂ in Si-Control. The glasses were then ground, sieved, characterized, and dissolved in Tris buffer solution (pH = 7...
April 11, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29601499/short-term-degradation-of-bi-component-electrospun-fibers-qualitative-and-quantitative-evaluations-via-afm-analysis
#11
Marica Marrese, Valentina Cirillo, Vincenzo Guarino, Luigi Ambrosio
Electrospun polymeric fibers are currently used as 3D models for in vitro applications in biomedical areas, i.e., tissue engineering, cell and drug delivery. The high customization of the electrospinning process offers numerous opportunities to manipulate and control surface area, fiber diameter, and fiber density to evaluate the response of cells under different morphological and/or biochemical stimuli. The aim of this study was to investigate-via atomic force microscopy (AFM)-the chemical and morphological changes in bi-component electrospun fibers (BEFs) during the in vitro degradation process using a biological medium...
March 30, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29561776/correction-w-c-mak-et-al-controlled-delivery-of-human-cells-by-temperature-responsive-microcapsules-j-funct-biomater-2015-6-439-453
#12
W C Mak, K Olesen, P Sivlér, C J Lee, I Moreno-Jimenez, J Edin, D Courtman, M Skog, M Griffith
Recently, we found a mistake in Figure 4D in our previously published paper[...].
March 21, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29562680/bioactive-glasses-where-are-we-and-where-are-we-going
#13
REVIEW
Francesco Baino, Sepideh Hamzehlou, Saeid Kargozar
Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery...
March 19, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29547544/bioactive-glasses-from-parent-45s5-composition-to-scaffold-assisted-tissue-healing-therapies
#14
REVIEW
Elisa Fiume, Jacopo Barberi, Enrica Verné, Francesco Baino
Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide...
March 16, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29538285/first-results-of-a-new-vacuum-plasma-sprayed-vps-titanium-coated-carbon-peek-composite-cage-for-lumbar-interbody-fusion
#15
Sven Hoppe, Christoph E Albers, Tarek Elfiky, Moritz C Deml, Helena Milavec, Sebastian F Bigdon, Lorin M Benneker
The aim of this study was to assess the performance of a new vacuum plasma sprayed (VPS) titanium-coated carbon/polyetheretherketone (PEEK) cage under first use clinical conditions. Forty-two patients who underwent a one or two segment transforaminal lumbar interbody fusion (TLIF) procedure with a new Ca/PEEK composite cage between 2012 and 2016 were retrospectively identified by an electronic patient chart review. Fusion rates (using X-ray), patient's satisfaction, and complications were followed up for two years...
March 14, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29494503/recent-advances-in-biomaterials-for-3d-printing-and-tissue-engineering
#16
REVIEW
Udayabhanu Jammalamadaka, Karthik Tappa
Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D printing in the field of regenerative medicine and tissue engineering are limited by the variety of biomaterials that can be used in this technology. Many researchers have developed novel biomaterials and compositions to enable their use in 3D printing methods. The advantages of fabricating scaffolds using 3D printing are numerous, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors...
March 1, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29495523/electron-beam-immobilization-of-novel-antimicrobial-short-peptide-motifs-leads-to-membrane-surfaces-with-promising-antibacterial-properties
#17
André Reinhardt, Isabell Thomas, Julie Schmauck, Ralf Giernoth, Agnes Schulze, Ines Neundorf
In this study, the efficacy of electron beam irradiation versus chemical coupling for yielding polyethersulfone (PES) membranes with antibacterial properties was investigated. For the surface coating, a recently discovered lead compound, IL-KKA, comprising a short peptide sequence functionalized with imidazolium groups, was used. For better integration within the membrane, several novel variants of IL-KKA were generated. Membrane immobilization was achieved using different doses of electron beam irradiation and NHS/EDC chemical coupling...
February 27, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29495522/antimicrobial-monomers-for-polymeric-dental-restoratives-cytotoxicity-and-physicochemical-properties
#18
Diane R Bienek, Stanislav A Frukhtbeyn, Anthony A Giuseppetti, Ugochukwu C Okeke, Drago Skrtic
A trend for the next generation of polymeric dental restoratives is to incorporate multifunctional capabilities to regulate microbial growth and remineralize tooth surfaces. Polymerizable 2-(methacryloyloxy)- N -(2-(methacryloyloxy)ethyl)- N , N -dimethylethan-1-aminium bromide (IDMA1) and N , N '-([1,1'-biphenyl]-2,2'-diylbis(methylene))bis(2-(methacryloyloxy)- N , N -dimethylethan-1-aminium) bromide (IDMA2), intended for utilization in bi-functional antimicrobial and remineralizing composites, were synthesized, purified with an ethanol-diethyl ether-hexane solvent system, and validated by nuclear magnetic resonance (¹H and 13 C NMR) spectroscopy, mass spectrometry, and Fourier-transform infrared spectroscopy...
February 27, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29495521/a-critical-review-on-metallic-glasses-as-structural-materials-for-cardiovascular-stent-applications
#19
REVIEW
Mehdi Jafary-Zadeh, Gideon Praveen Kumar, Paulo Sergio Branicio, Mohsen Seifi, John J Lewandowski, Fangsen Cui
Functional and mechanical properties of novel biomaterials must be carefully evaluated to guarantee long-term biocompatibility and structural integrity of implantable medical devices. Owing to the combination of metallic bonding and amorphous structure, metallic glasses (MGs) exhibit extraordinary properties superior to conventional crystalline metallic alloys, placing them at the frontier of biomaterials research. MGs have potential to improve corrosion resistance, biocompatibility, strength, and longevity of biomedical implants, and hence are promising materials for cardiovascular stent applications...
February 27, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29495358/modulation-of-osteoclast-interactions-with-orthopaedic-biomaterials
#20
REVIEW
Chris Steffi, Zhilong Shi, Chee Hoe Kong, Wilson Wang
Biomaterial integration in bone depends on bone remodelling at the bone-implant interface. Optimal balance of bone resorption by osteoclasts and bone deposition by osteoblasts is crucial for successful implantation, especially in orthopaedic surgery. Most studies examined osteoblast differentiation on biomaterials, yet few research has been conducted to explore the effect of different orthopaedic implants on osteoclast development. This review covers, in detail, the biology of osteoclasts, in vitro models of osteoclasts, and modulation of osteoclast activity by different implant surfaces, bio-ceramics, and polymers...
February 26, 2018: Journal of Functional Biomaterials
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