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Journal of Functional Biomaterials

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https://www.readbyqxmd.com/read/28294960/overview-of-potential-clinical-applications-of-hemoglobin-vesicles-hbv-as-artificial-red-cells-evidenced-by-preclinical-studies-of-the-academic-research-consortium
#1
REVIEW
Hiromi Sakai
Hemoglobin (Hb) is the most abundant protein in whole blood. This fact implies that the oxygen binding and releasing function of Hb is the most vital for sustaining life. All Hb is compartmentalized in red blood cells (RBCs) with corpuscular Hb concentration of about 35 g/dL, covered with a thin biomembrane. In spite of its abundance, Hb sometimes shows toxicity once it is leaked from RBCs. The shielding effect of the RBC membrane is physiologically important. Based on this structural importance, we have studied artificial red cells (Hb vesicles, HbV) as artificial oxygen carriers, which encapsulate a purified and concentrated Hb solution in phospholipid vesicles, mimicking the cellular structure of RBCs...
March 15, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28272304/induction-of-low-level-hydrogen-peroxide-generation-by-unbleached-cotton-nonwovens-as-potential-wound-dressing-materials
#2
J Vincent Edwards, Nicolette T Prevost, Sunghyun Nam, Doug Hinchliffe, Brian Condon, Dorne Yager
Greige cotton is an intact plant fiber. The cuticle and primary cell wall near the outer surface of the cotton fiber contains pectin, peroxidases, superoxide dismutase (SOD), and trace metals, which are associated with hydrogen peroxide (H₂O₂) generation during cotton fiber development. Traditionally, the processing of cotton into gauze involves scouring and bleaching processes that remove the components in the cuticle and primary cell wall. The use of unbleached, greige cotton fibers in dressings, has been relatively unexplored...
March 6, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28264515/fabrication-and-optimal-design-of-biodegradable-polymeric-stents-for-aneurysms-treatments
#3
Xue Han, Xia Wu, Michael Kelly, Xiongbiao Chen
An aneurysm is a balloon-like bulge in the wall of blood vessels, occurring in major arteries of the heart and brain. Biodegradable polymeric stent-assisted coiling is expected to be the ideal treatment of wide-neck complex aneurysms. This paper presents the development of methods to fabricate and optimally design biodegradable polymeric stents for aneurysms treatment. Firstly, a dispensing-based rapid prototyping (DBRP) system was developed to fabricate coil and zigzag structures of biodegradable polymeric stents...
February 28, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28216559/aloe-vera-for-tissue-engineering-applications
#4
REVIEW
Shekh Rahman, Princeton Carter, Narayan Bhattarai
Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components...
February 14, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28208801/atomic-force-microscopy-a-powerful-tool-to-address-scaffold-design-in-tissue-engineering
#5
Marica Marrese, Vincenzo Guarino, Luigi Ambrosio
Functional polymers currently represent a basic component of a large range of biological and biomedical applications including molecular release, tissue engineering, bio-sensing and medical imaging. Advancements in these fields are driven by the use of a wide set of biodegradable polymers with controlled physical and bio-interactive properties. In this context, microscopy techniques such as Atomic Force Microscopy (AFM) are emerging as fundamental tools to deeply investigate morphology and structural properties at micro and sub-micrometric scale, in order to evaluate the in time relationship between physicochemical properties of biomaterials and biological response...
February 13, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28134777/the-anti-inflammatory-and-vasodilating-effects-of-three-selected-dietary-organic-sulfur-compounds-from-allium-species
#6
Chin-Chen Chu, Wen-Shiann Wu, Ja-Ping Shieh, Heuy-Ling Chu, Chia-Pu Lee, Pin-Der Duh
The anti-inflammatory and vasodilating effects of three selected dietary organic sulfur compounds (OSC), including diallyl disulfide (DADS), dimethyl disulfide (DMDS), and propyl disulfide (PDS), from Allium species were investigated. In the anti-inflammatory activity assay, the three OSC demonstrated significant inhibition of nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in LPS-induced RAW 264.7 cells. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in activated RAW 264...
January 26, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28134776/bioactive-polymeric-materials-for-tissue-repair
#7
Diane R Bienek, Wojtek Tutak, Drago Skrtic
Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP's dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites...
January 26, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28117733/minimizing-skin-scarring-through-biomaterial-design
#8
REVIEW
Alessandra L Moore, Clement D Marshall, Michael T Longaker
Wound healing continues to be a major burden to patients, though research in the field has expanded significantly. Due to an aging population and increasing comorbid conditions, the cost of chronic wounds is expected to increase for patients and the U.S. healthcare system alike. With this knowledge, the number of engineered products to facilitate wound healing has also increased dramatically, with some already in clinical use. In this review, the major biomaterials used to facilitate skin wound healing will be examined, with particular attention allocated to the science behind their development...
January 21, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28085047/optimization-of-polymer-ecm-composite-scaffolds-for-tissue-engineering-effect-of-cells-and-culture-conditions-on-polymeric-nanofiber-mats
#9
Ritu Goyal, Murat Guvendiren, Onyi Freeman, Yong Mao, Joachim Kohn
The design of composite tissue scaffolds containing an extracellular matrix (ECM) and synthetic polymer fibers is a new approach to create bioactive scaffolds that can enhance cell function. Currently, studies investigating the effects of ECM-deposition and decellularization on polymer degradation are still lacking, as are data on optimizing the stability of the ECM-containing composite scaffolds during prolonged cell culture. In this study, we develop fibrous scaffolds using three polymer compositions, representing slow (E0000), medium (E0500), and fast (E1000) degrading materials, to investigate the stability, degradation, and mechanics of the scaffolds during ECM deposition and decellularization, and during the complete cellularization-decell-recell cycle...
January 11, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27983574/use-of-micropatterned-thin-film-nitinol-in-carotid-stents-to-augment-embolic-protection
#10
Mahdis Shayan, Brian T Jankowitz, Puneeth Shridhar, Youngjae Chun
Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism during carotid intervention. This innovation may obviate the need or work synergistically with embolic protection devices...
December 13, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27941669/responses-of-vascular-endothelial-cells-to-photoembossed-topographies-on-poly-methyl-methacrylate-films
#11
Lin Qiu, Nanayaa F Hughes-Brittain, Cees W M Bastiaansen, Ton Peijs, Wen Wang
Failures of vascular grafts are normally caused by the lack of a durable and adherent endothelium covering the graft which leads to thrombus and neointima formation. A promising approach to overcome these issues is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. The present study reports for the first time on the use of photoembossing as a technique to create polymer films with different topographical features for improved cell interaction in biomedical applications...
December 9, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27916951/silica-based-and-borate-based-titania-containing-bioactive-coatings-characterization-critical-strain-energy-release-rate-residual-stresses-hardness-and-thermal-expansion
#12
Omar Rodriguez, Ali Matinmanesh, Sunjeev Phull, Emil H Schemitsch, Paul Zalzal, Owen M Clarkin, Marcello Papini, Mark R Towler
Silica-based and borate-based glass series, with increasing amounts of TiO₂ incorporated, are characterized in terms of their mechanical properties relevant to their use as metallic coating materials. It is observed that borate-based glasses exhibit CTE (Coefficient of Thermal Expansion) closer to the substrate's (Ti6Al4V) CTE, translating into higher mode I critical strain energy release rates of glasses and compressive residual stresses and strains at the coating/substrate interface, outperforming the silica-based glasses counterparts...
December 1, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27916868/characterization-and-schwann-cell-seeding-of-up-to-15-0-cm-long-spider-silk-nerve-conduits-for-reconstruction-of-peripheral-nerve-defects
#13
Tim Kornfeld, Peter M Vogt, Vesna Bucan, Claas-Tido Peck, Kerstin Reimers, Christine Radtke
Nerve reconstruction of extended nerve defect injuries still remains challenging with respect to therapeutic options. The gold standard in nerve surgery is the autologous nerve graft. Due to the limitation of adequate donor nerves, surgical alternatives are needed. Nerve grafts made out of either natural or artificial materials represent this alternative. Several biomaterials are being explored and preclinical and clinical applications are ongoing. Unfortunately, nerve conduits with successful enhancement of axonal regeneration for nerve defects measuring over 4...
November 30, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27916829/in-vitro-study-of-a-superhydrophilic-thin-film-nitinol-endograft-that-is-electrostatically-endothelialized-in-the-catheter-prior-to-the-endovascular-procedure
#14
Mahdis Shayan, Yanfei Chen, Puneeth Shridhar, Colin P Kealey, YoungJae Chun
Electrostatic endothelial cell seeding has evolved as an exceptional technique to improve the efficiency of cell seeding in terms of frequency of attached cells and the amount of cell adhesion for the treatment of vascular diseases. In the recent times, both untreated and superhydrophilic thin film nitinol (TFN) have exhibited strong prospects as substrates for creation of small-diameter endovascular grafts due to their hallmark properties of superelasticity, ultra low-profile character, and grown hemocompatible oxide layer with the presence of a uniform endothelial layer on the surface...
November 29, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27869709/cerebral-microvascular-and-systemic-effects-following-intravenous-administration-of-the-perfluorocarbon-emulsion-perftoran
#15
Rania Abutarboush, Biswajit K Saha, Saad H Mullah, Francoise G Arnaud, Ashraful Haque, Chioma Aligbe, Georgina Pappas, Charles R Auker, Richard M McCarron, Paula F Moon-Massat, Anke H Scultetus
Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects...
November 18, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27763503/debris-evaluation-after-root-canal-shaping-with-rotating-and-reciprocating-single-file-systems
#16
Alberto Dagna, Giulia Gastaldo, Riccardo Beltrami, Claudio Poggio
This study evaluated the root canal dentine surface by scanning electron microscope (SEM) after shaping with two reciprocating single-file NiTi systems and two rotating single-file NiTi systems, in order to verify the presence/absence of the smear layer and the presence/absence of open tubules along the walls of each sample; Forty-eight single-rooted teeth were divided into four groups and shaped with OneShape (OS), F6 SkyTaper (F6), WaveOne (WO) and Reciproc and irrigated using 5.25% NaOCl and 17% EDTA. Root canal walls were analyzed by SEM at a standard magnification of 2500×...
October 17, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27649252/synthesis-and-characterization-of-nanodiamond-reinforced-chitosan-for-bone-tissue-engineering
#17
Yu Sun, Qiaoqin Yang, Haidong Wang
Multifunctional tissue scaffold material nanodiamond (ND)/chitosan (CS) composites with different diamond concentrations from 1 wt % to 5 wt % were synthesized through a solution casting method. The microstructure and mechanical properties of the composites were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and nanoindentation. Compared with pristine CS, the addition of ND resulted in a significant improvement of mechanical properties, including a 239%, 276%, 321%, 333%, and 343% increase in Young's modulus and a 68%, 96%, 114%, 118%, and 127% increase in hardness when the ND amount was 1 wt %, 2 wt %, 3 wt %, 4 wt %, and 5 wt %, respectively...
September 15, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27649251/processing-techniques-and-applications-of-silk-hydrogels-in-bioengineering
#18
REVIEW
Michael Floren, Claudio Migliaresi, Antonella Motta
Hydrogels are an attractive class of tunable material platforms that, combined with their structural and functional likeness to biological environments, have a diversity of applications in bioengineering. Several polymers, natural and synthetic, can be used, the material selection being based on the required functional characteristics of the prepared hydrogels. Silk fibroin (SF) is an attractive natural polymer for its excellent processability, biocompatibility, controlled degradation, mechanical properties and tunable formats and a good candidate for the fabrication of hydrogels...
September 14, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27626452/a-smart-ph-responsive-three-components-luminescent-hydrogel
#19
Yibao Li, Wei Liu, Linxiu Cheng, Ping Huang, Yu Peng, Yongquan Wu, Xun Li, Xiaokang Li, Xiaolin Fan
In this study, we report a novel three-component luminescent hydrogel, which is composed of amino acid derivatives (N,N'-di valine-3,4,9,10-perylenetetracarboxylic acid, NVPD), riboflavin (RF), and melamine (MM). The three-component hydrogel is attributed to multiple hydrogen bonds and the strong π-π stacking interaction between these molecules. Based on the strong hydrogen bonding of the gelator, when the reversible process between the gel and the solution take places it changes the pH of the system from 6...
September 12, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27626451/photocrosslinkable-trehalose-derivatives-carrying-mesogenic-groups-synthesis-characterization-and-in-vitro-evaluation-for-fibroblast-attachment
#20
Shinya Yano, Naozumi Teramoto, Toshiaki Shimasaki, Mitsuhiro Shibata
A photocrosslinkable trehalose derivative carrying mesogenic groups was synthesized by esterification reactions. The derivative (TC-HBPHA) was synthesized by the reaction of partially cinnamoyl-modified trehalose (TC4) with 4-(4-hexyloxybenzoyloxy)phenoxy-6-oxohexanoic acid (HBPHA) as a mesogenic unit. TC-HBPHA showed a nematic liquid crystalline mesophase at a temperature range from 150 °C to 175 °C in the heating process under observation with a polarized optical microscope. The dimerization of the cinnamoyl groups of TC-HBPHA by ultraviolet (UV) light irradiation was monitored by ultraviolet-visible (UV-Vis) spectroscopy and Fourier transform infrared (FT-IR) spectroscopy...
September 10, 2016: Journal of Functional Biomaterials
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