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Journal of Functional Biomaterials

Laurence Cantin-Warren, Rina Guignard, Sergio Cortez Ghio, Danielle Larouche, François A Auger, Lucie Germain
There is a high incidence of failure and recurrence for chronic skin wounds following conventional therapies. To promote healing, the use of skin substitutes containing living cells as wound dressings has been proposed. The aim of this study was to produce a scaffold-free cell-based bilayered tissue-engineered skin substitute (TES) containing living fibroblasts and keratinocytes suitable for use as wound dressing, while considering production time, handling effort during the manufacturing process, and stability of the final product...
September 15, 2018: Journal of Functional Biomaterials
Ameya Sharma, Vivek Puri, Vandita Kakkar, Inderbir Singh
Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement of ulcerative index; the determination of gastric wall mucus; and the determination of percentage protection, biochemical, and histopathological studies were also performed. Microbeads batches were evaluated for particle size (120⁻140 µm), actual drug content, (49...
September 10, 2018: Journal of Functional Biomaterials
Mythili Prakasam, Ali Chirazi, Grzegorz Pyka, Anna Prokhodtseva, Daniel Lichau, Alain Largeteau
Biomaterial for tissue engineering is a topic of huge progress with a recent surge in fabrication and characterization advances. Biomaterials for tissue engineering applications or as scaffolds depend on various parameters such as fabrication technology, porosity, pore size, mechanical strength, and surface available for cell attachment. To serve the function of the scaffold, the porous biomaterial should have enough mechanical strength to aid in tissue engineering. With a new manufacturing technology, we have obtained high strength materials by optimizing a few processing parameters such as pressure, temperature, and dwell time, yielding the monolith with porosity in the range of 80%⁻93%...
August 24, 2018: Journal of Functional Biomaterials
Ludovica Parisi, Andrea Toffoli, Giulia Ghiacci, Guido M Macaluso
Tissue engineering (TE) is a multidisciplinary science, which including principles from material science, biology and medicine aims to develop biological substitutes to restore damaged tissues and organs. A major challenge in TE is the choice of suitable biomaterial to fabricate a scaffold that mimics native extracellular matrix guiding resident stem cells to regenerate the functional tissue. Ideally, the biomaterial should be tailored in order that the final scaffold would be (i) biodegradable to be gradually replaced by regenerating new tissue, (ii) mechanically similar to the tissue to regenerate, (iii) porous to allow cell growth as nutrient, oxygen and waste transport and (iv) bioactive to promote cell adhesion and differentiation...
August 21, 2018: Journal of Functional Biomaterials
Kenji Mishima, Xiaoyu Du, Naoto Miyamoto, Naoki Kano, Hiroshi Imaizumi
An experiment on the adsorption of uranium (VI) by chitosan was conducted to investigate the efficiency of chitosan as an adsorbent for U(VI). The adsorption potential of U(VI) by chitosan was investigated with ICP-MS by varying the experimental conditions such as the pH in order to obtain the optimum conditions. Adsorption dependence on the pH was confirmed, and the highest uptake of U(VI) was observed at pH 5. In addition, to scrutinize the experimental results, quantum chemistry calculations were performed...
August 9, 2018: Journal of Functional Biomaterials
Renzo Guarnieri, Fabrizio Belleggia, Patricia DeVillier, Luca Testarelli
Anorganic bovine bone mineral matrix (ABBMM) has been reported to have osteoconductive properties and no inflammatory or adverse responses when used as grafting material in sinus augmentation procedures. However, controversy remains in regard to degradation rate of ABBMM. The aim of this study was to histologically and histomorphometrically evaluate the degradation of ABBMM in human bone samples obtained in one patient 24 months after sinus augmentation. MATERIALS AND METHODS: The histologic and histomorphometric analysis was performed by means of light microscopy in three specimens harvested from the same patient, Results: After 24 months the tissue pattern appeared to be composed of residual particles, some in close contact with the newly formed bone, others separated by translucent areas and osteoid tissues...
August 8, 2018: Journal of Functional Biomaterials
Basel A Khader, Omar Rodriguez, Mark R Towler
The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO₂⁻0.12CaO⁻0.36ZnO⁻0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass polyalkenoate cements (GPCs) manufactured from them. The Network connectivity (NC) of the glass was calculated to increase from 1.83 to 2.42 with the addition of GeO₂ (0⁻8 mol %). Differential thermal analysis (DTA) results confirmed an increase in the glass transition temperature ( Tg ) of the glass series with GeO₂ content...
July 31, 2018: Journal of Functional Biomaterials
Angela Alarcon de la Lastra, Katherine R Hixon, Lavanya Aryan, Amanda N Banks, Alexander Y Lin, Andrew F Hall, Scott A Sell
The current gold standard treatment for oral clefts is autologous bone grafting. This treatment, however, presents another wound site for the patient, greater discomfort, and pediatric patients have less bone mass for bone grafting. A potential alternative treatment is the use of tissue engineered scaffolds. Hydrogels are well characterized nanoporous scaffolds and cryogels are mechanically durable, macroporous, sponge-like scaffolds. However, there has been limited research on these scaffolds for cleft craniofacial defects...
July 24, 2018: Journal of Functional Biomaterials
Daniel N Bracey, Thorsten M Seyler, Alexander H Jinnah, Mark O Lively, Jeffrey S Willey, Thomas L Smith, Mark E Van Dyke, Patrick W Whitlock
BACKGROUND: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but is limited in supply and its harvest imparts significant morbidity to the patient. Alternative sources of bone graft include allografts, synthetics and, less commonly, xenografts which are taken from animal species. Xenografts are available in unlimited supply from healthy animal donors with controlled biology, avoiding the risk of human disease transmission, and may satisfy current demand for bone graft products...
July 12, 2018: Journal of Functional Biomaterials
Ortensia Ilaria Parisi, Luca Scrivano, Fabio Amone, Rocco Malivindi, Mariarosa Ruffo, Anna Francesca Vattimo, Vincenzo Pezzi, Francesco Puoci
Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel anti-baldness agent based on Interconnected PolymerS TeChnology (IPSTiC), which is an effective strategy for the delivery of bioactive molecules, was developed. This product (IPSTiC patch hair) is based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins and is able to improve efficacy and stability of bioactive ingredients such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract...
July 12, 2018: Journal of Functional Biomaterials
Jennifer Gansau, Conor Timothy Buckley
Hydrogels, such as fibrin, offer a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to regenerate damaged disc tissue as a potential treatment for low back pain. However, fibrin lacks key extracellular matrix (ECM) components, such as collagen (Col) and hyaluronan (HA), normally found in native nucleus pulposus (NP) tissue. The overall aim of this work was to create a fibrin-based hydrogel, by incorporating Col and HA into the matrix to enhance NP-like matrix accumulation using articular chondrocytes (CC)...
July 10, 2018: Journal of Functional Biomaterials
Nikolaos-Stefanos Kampanas, Maria Antoniadou
BACKGROUND: The restoration of non-carious cervical lesions in geriatric patients is a demanding process. Glass ionomer cements can be promising materials for the management of these lesions in older adults. The aim of this literature review is to present the benefits of glass ionomers and how they can be used for the restoration of non-carious cervical lesions of older adults depending on the geriatric patient's profile. DATA SOURCES: All available in vitro and in vivo studies from Google Scholar, PubMed and Scopus search engines corresponding to glass ionomer cements, geriatric dentistry, elderly patients, and non-carious lesions as key words were reviewed...
July 8, 2018: Journal of Functional Biomaterials
Jan Sher Akmal, Mika Salmi, Antti Mäkitie, Roy Björkstrand, Jouni Partanen
The purpose of this study is to demonstrate the ability of additive manufacturing, also known as 3D printing, to produce effective drug delivery devices and implants that are both identifiable, as well as traceable. Drug delivery devices can potentially be used for drug release in the direct vicinity of target tissues or the selected medication route in a patient-specific manner as required. The identification and traceability of additively manufactured implants can be administered through radiofrequency identification systems...
June 29, 2018: Journal of Functional Biomaterials
Daniela A Frauchiger, Rahel D May, Ezgi Bakirci, Adel Tekari, Samantha C W Chan, Michael Wöltje, Lorin M Benneker, Benjamin Gantenbein
(1) Background: Intervertebral disc (IVD) repair represents a major challenge. Using functionalised biomaterials such as silk combined with enforced hydrogels might be a promising approach for disc repair. We aimed to test an IVD repair approach by combining a genipin-enhanced fibrin hydrogel with an engineered silk scaffold under complex load, after inducing an injury in a bovine whole organ IVD culture; (2) Methods: Bovine coccygeal IVDs were isolated from ~1-year-old animals within four hours post-mortem...
June 24, 2018: Journal of Functional Biomaterials
Melissa J Black, Adam A Lucero, Philip W Fink, Lee Stoner, Sarah P Shultz, Sally D Lark, David S Rowlands
The increased risk of falls associated with advancing age has increased demand for methods to improve balance and mobility. The primary purpose of the study was to determine whether wearing Aqua Titan-treated stockings could improve balance and walking performance in an older population; secondary was to elucidate the mechanisms. In a randomized, double-blind crossover, 16 healthy older adults (age, 67.9 ± 4.2 years; BMI, 24.8 ± 3.1 kg/m²) performed two 4-day trials composed of baseline measures and fatiguing exercise on Day 1, with recovery measures at 14, 38 and 62 h post-exercise, wearing Aqua Titan and control stockings...
June 8, 2018: Journal of Functional Biomaterials
Kazuo Azuma, Ryotaro Izumi, Tomohiro Osaki, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki Saimoto, Saburo Minami, Yoshiharu Okamoto
The Journal of Functional Biomaterials Editorial Office have been made aware that some parts of the article [1] are duplicated from other publications[...].
June 7, 2018: Journal of Functional Biomaterials
Giacomo D'Angelo, Amal Elhussieny, Marwa Faisal, I S Fahim, Nicola M Everitt
The use of biodegradable materials for shopping bag production, and other products made from plastics, has recently been an object of intense research-with the aim of reducing the environmental burdens given by conventional materials. Chitosan is a potential material because of its biocompatibility, degradability, and non-toxicity. It is a semi-natural biopolymeric material produced by the deacetylation of chitin, which is the second most abundant natural biopolymer (after cellulose). Chitin is found in the exoskeleton of insects, marine crustaceans, and the cell walls of certain fungi and algae...
May 22, 2018: Journal of Functional Biomaterials
Wan Khartini Wan Abdul Khodir, Abdul Hakim Abdul Razak, Min Hwei Ng, Vincenzo Guarino, Deny Susanti
In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment...
May 18, 2018: Journal of Functional Biomaterials
Timur Sh Atabaev, Zhonglie Piao, Anara Molkenova
In recent years, functional nanoprobes with multiple imaging modalities have become an emerging field of biomedical research. In this preliminary study, we utilized a facile hydrothermal method for the preparation of magneto-fluorescent bimodal carbon dots doped with dysprosium (Dy-CDs). The prepared Dy-CDs have shown a good colloidal stability in a water solution and strong blue⁻green fluorescence, with a maximum at 452 nm. In addition, the excellent transverse relaxivity of the prepared Dy-CDs (r₂ = 7...
May 18, 2018: Journal of Functional Biomaterials
Simona Martinotti, Elia Ranzato
Honey possesses anti-bacterial, anti-inflammatory and other properties that are useful for wound healing and tissue regeneration. Furthermore, honey has been used for millennia in folk medicine. The misuse of antibiotics has again boosted the use of honey in regenerative medicine. The multifaceted properties of honey could possibly be exploited for scaffold applications in tissue healing.
May 8, 2018: Journal of Functional Biomaterials
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