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Journal of Trauma and Acute Care Surgery

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https://www.readbyqxmd.com/read/30399139/isoform-6-selective-histone-deacetylase-inhibition-reduces-lesion-size-and-brain-swelling-following-traumatic-brain-injury-and-hemorrhagic-shock
#1
Vahagn C Nikolian, Isabel S Dennahy, Michael Weykamp, Aaron M Williams, Umar F Bhatti, Hassan Eidy, Mohamed Ghandour, Kiril Chtraklin, Yongqing Li, Hasan B Alam
BACKGROUND: Non-selective histone deacetylase (pan-HDAC) inhibitors, such as valproic acid (VPA), have demonstrated neuroprotective properties in trauma models. However, isoform-specific HDAC inhibitors may provide opportunity for more effective drug administration with lesser side effects. We investigated HDAC6 inhibition with ACY-1083 in an in vitro and an in vivo large animal model of injury. METHODS: Mouse hippocampal cells were subjected to oxygen-glucose deprivation (0% O2, glucose-free, serum-free medium, 18 hours) and reoxygenation (21% O2, normal culture media, 4 hours) +/- VPA (4mM) or ACY1083 (30nM, 300nM)...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399138/impact-of-aca-related-insurance-expansion-policies-on-mortality-and-access-to-post-discharge-care-for-trauma-patients-an-analysis-of-the-national-trauma-data-bank
#2
John W Scott, Pooja U Neiman, Tarsicio Uribe-Leitz, Kirstin W Scott, Cheryl K Zogg, Ali Salim, Adil Haider
BACKGROUND: Uninsured trauma patients have worse outcomes and worse access to post-discharge care that is critically important for recovery after injury. Little is known regarding the impact of the insurance coverage expansion policies of the Affordable Care Act (ACA), most notably state-level Medicaid expansion, on trauma patients. In this study, we examine the national impact of these policies on payer-mix, inpatient mortality, and access to post-acute care for trauma patients. METHODS: We used the 2011-2016 National Trauma Data Bank to evaluate for changes in insurance coverage among 18-64 year-old trauma patients...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399137/the-current-status-of-clinical-trials-in-emergency-gastrointestinal-surgery-a-systematic-analysis-of-contemporary-clinical-trials
#3
Amelia Milton, Thomas M Drake, Matthew J Lee
BACKGROUND: Emergency gastrointestinal surgery (EGS) conditions represent a significant healthcare burden globally requiring emergency operations that are associated with mortality rates as high as 80%. EGS is currently focussed on quality improvement and internal audits, which occurs at a national or local level. An appreciation of what EGS trials are being conducted is important to reduce research wastage and develop coordinated research strategies in surgery. The primary aim of this study was to identify and quantify recent and active trials in emergency gastrointestinal surgery...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399136/outcomes-for-popliteal-artery-injury-repair-after-discharge-a-large-scale-population-based-analysis
#4
William J Butler, Richard Y Calvo, Michael J Sise, Jason M Bowie, Lyndsey E Wessels, Vishal Bansal, C Beth Sise
BACKGROUND: Although short-term outcomes for popliteal artery injury after endovascular versus open repair appear similar, studies on outcomes after discharge are limited. We evaluated popliteal artery injury repair in a population-based dataset. We hypothesized that post-discharge outcomes for open repair are superior to endovascular repair. METHODS: Patients with popliteal artery injury were identified in the California Office of Statewide Health Planning and Development 2007-2014 discharge database...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399135/impact-of-contrast-extravasation-on-computed-tomography-of-the-psoas-major-muscle-in-patients-with-blunt-torso-trauma
#5
Tetsuya Yumoto, Hiromichi Naito, Takao Hiraki, Yasuaki Yamakawa, Taihei Yamada, Atsunori Nakao
BACKGROUND: The clinical significance of contrast extravasation (CE) on computed tomography (CT) of the psoas major muscle after blunt torso trauma and the optimal management of patients requiring transcatheter arterial embolization (TAE) of the lumbar artery have not been well elucidated. The aim of this study was to investigate the impact of CE on CT to determine the need for TAE of the lumbar artery. METHODS: We examined a single-center retrospective cohort of blunt torso trauma patients who underwent contrast-enhanced CT from 2008 through 2017...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399134/nf-%C3%AE%C2%BAb-mediates-early-blood-brain-barrier-disruption-in-a-rat-model-of-traumatic-shock
#6
Zhe Deng, Dehong Liu, Tingping Fu, Wenqiang Jiang, Min Qiu, Xiaoyong Xiao, Ji Xu, Yongwen Feng, Danhui Li, Hongke Zeng
BACKGROUND: Blood-brain barrier (BBB) disruption is associated with a large number of central nervous system and systemic disorders. The aim of the present study was to investigate the dynamic change of BBB changes during traumatic shock and resuscitation as well as the mechanisms involved. METHODS: The experiments were carried out on male Sprague Dawley rats anaesthetized with pentobarbital sodium. To produce traumatic shock, the rats were subjected to bilateral femoral traumatic fracture and blood withdrawal from the femoral artery to decrease mean arterial pressure (MAP) to 35 mmHg...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399133/loop-ileostomy-for-c-difficile-infection-important-considerations
#7
Paula Ferrada
No abstract text is available yet for this article.
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399132/in-reply-trauma-pneumonectomy-for-major-thoracic-bleeding-when-should-we-consider-it
#8
Kazuhide Matsushima, Demetrios Demetriades
No abstract text is available yet for this article.
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399131/a-comparison-of-cholecystitis-grading-scales
#9
Tarik D Madni, Paul A Nakonezny, Jonathan B Imran, Luis Taveras, Holly B Cunningham, Ryan Vela, Audra T Clark, Christian T Minshall, Alexander L Eastman, Stephen Luk, Herb A Phelan, Michael W Cripps
BACKGROUND: Previously, our group developed the Parkland Grading Scale for Cholecystitis (PGS) to stratify gallbladder (GB) disease severity that can be determined immediately when performing laparoscopic cholecystectomy (LC). In prior studies, PGS demonstrated excellent interrater reliability and was internally validated as an accurate measure of LC outcomes. Here, we compare PGS against a more complex cholecystitis severity score developed by the national trauma society (AAST), which requires clinical, operative, imaging, and pathologic inputs, as a predictor of LC outcomes...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399130/a-novel-treatment-option-in-the-management-of-traumatic-haemothorax
#10
Navneet Singh, Damian Gimpel, Zubayr Zaman, Rowan French, Paul Conaglen
No abstract text is available yet for this article.
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30399129/the-impact-of-frailty-on-acute-care-general-surgery-patients-a-systematic-review
#11
Mellissa A R Ward, Abdullah Alenazi, Megan Delisle, Sarvesh Logsetty
BACKGROUND: Frailty may predict negative health outcomes more accurately than chronological age alone. This review examines evidence for the impact of frailty on adverse outcomes in patients admitted with an acute care general surgery (ACS) diagnosis. METHODS: A systematic literature search for studies reporting frailty and outcomes after admission with an ACS diagnosis was performed. We searched PubMed and SCOPUS from inception until September 2017. RESULTS: A total of 8668 records were screened of which seven studies examined the relationship between frailty and outcomes in ACS patients...
November 5, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30371625/the-las-vegas-mass-shooting-an-analysis-of-blood-component-administration-and-blood-bank-donations
#12
M James Lozada, Stephanie Cai, Marissa Li, Stephanie Lynne Davidson, Justin Nix, Glenn Ramsey
BACKGROUND: The deadliest mass shooting in modern United States history occurred October 1, 2017 in Las Vegas, killing 58 and overwhelming hospitals with over 600 injured. The scope of the tragedy offers insight into medical demands, which may help guide preparedness for future mass shooting incidents. METHODS: Retrospective, de-identified, healthcare institution-provided data from all hospitals and blood banks providing care to Las Vegas shooting victims was gathered...
November 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30395013/sarcopenia-as-a-tool-for-preoperative-decision-making
#13
Erika L Rangel, Arturo J Rios-Diaz, Jennifer W Uyeda, Manuel Castillo-Angeles, Zara Cooper, Olubode A Olufajo, Ali Salim, Aaron D Sodickson
No abstract text is available yet for this article.
November 1, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30395012/perioperative-glycemic-control-and-postoperative-complications-in-patients-undergoing-emergency-general-surgery-what-is-the-role-of-hba1c
#14
Faisal Jehan, Bellal Joseph
No abstract text is available yet for this article.
November 1, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30376550/response-to-the-letter-to-the-editor-by-drs-isci-and-ritter-clinical-features-of-27-shark-attack-cases-on-la-r%C3%A3-union-island
#15
Richard Ballas
No abstract text is available yet for this article.
October 29, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30376549/response-to-letter-to-the-editor-by-dr-magnone-jt-d-18-08024
#16
Fredric M Pieracci
No abstract text is available yet for this article.
October 29, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30376548/in-response-to-the-letter-to-the-editor-beta-blockers-therapy-in-traumatic-brain-injury-is-it-the-time-to-disclose-the-brain-cardiac-interactions
#17
Eric J Ley, Navpreet K Dhillon, Galinos Barmparas
No abstract text is available yet for this article.
October 29, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30376547/response-to-chemoprophylaxis-for-vte-prevention-in-spine-surgery-patients
#18
John P Sharpe, Timothy C Fabian, Martin A Croce, Louis J Magnotti
No abstract text is available yet for this article.
October 29, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30376546/reply-to-laparoscopy-in-a-combat-theater-of-operations
#19
Zsolt T Stockinger, Caryn A Turner, Jennifer M Gurney
No abstract text is available yet for this article.
October 29, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30376545/response-to-letter-to-the-editor
#20
Hayley L Letson, Geoffrey P Dobson
No abstract text is available yet for this article.
October 29, 2018: Journal of Trauma and Acute Care Surgery
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