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Environmental Health and Toxicology

Jihyun Emma Choi PhD, Sang-Bum Hong Md PhD, Kyung-Hyun Do Md PhD, Hwa Jung Kim Md PhD, Seockhoon Chung Md PhD, Eun Lee Md PhD, Jihyun Choi, Soo-Jong Hong
A large portion of the Korean population has been exposed to toxic humidifier disinfectants, and considering that the majority of the victims are infants, the magnitude of the damage is expected to be considerably larger than what has currently been revealed. The current victims are voicing problems caused by various diseases, including but not limited to lung, upper respiratory tract, cardiovascular, kidney, musculoskeletal, eye, and skin diseases, etc. However, there has been difficulty in gaining validation for these health problems and identifying causal relationships due to lack of evidence proving that toxic humidifier disinfectant is the specific causes of extrapulmonary diseases such as allergic rhinitis...
August 29, 2016: Environmental Health and Toxicology
Hee Chan Kim, Sangchul Roh
Objectives: This study aimed to evaluate the relationship between residential district of people, such as power plant, steel-mill and petrochemical industries, and health-related quality of life. Methods: Using a cross-sectional study design, we randomly recruited paticipants for our study from industrial areas(thermoelectric power plant, steel-mill, petrochemical industry) and rural areas. Logistic regression analysis was used to identify the relationships between EQ-5D scores and living region, while controlling for sociodemographic characteristics...
August 26, 2016: Environmental Health and Toxicology
Yosub Joo, Sangchul Roh
Objectives: This study aimed to evaluate the risk factors associated with depression and suicidal ideation in a rural population. Methods: A survey was conducted with 543 farmers from Chungcheongnam province using the Center for Epidemiologic Studies Depression Scale (CES-D) for depression, Lubben Social Network Scale (LSNS) for social support, Swedish Q16 for neurotoxicity symptoms and Park, Kim, and Chon's survey tool for farmer's syndrome. Results: After adjusting for socioeconomic factors using logistic regression analysis, poor self-rated health, low social support and neurotoxicity were positively associated with the risk of depression (OR=9...
August 26, 2016: Environmental Health and Toxicology
Jun Hyeon Jo, Sun Joo Kim, Woong-Shik Nam, Eunji Sung, Sangkyu Lee
Objectives: Banha-sasim-tang (BST), which consists of seven different herbs, is one of the most popular herbal formulae for treating gastrointestinal disorders in Eastern Asia. The commonly used herbal medicine is often co-administered with other therapeutic drugs, which raises the possibility of herb-drug interactions and may modify the clinical safety profile of therapeutic drugs. Methods: We investigated the potential herb-drug interactions between BST extract and midazolam (MDZ) in mice...
August 9, 2016: Environmental Health and Toxicology
Taehyun Park
A relief system applicable to the damages incurred by the humidifier disinfectants should be revised. It needs to create an institutional environment for the establishment of a risk management system inside corpotate. To this end, intruducing a set of legal systems, including punitive damages, must be reviewed. Also a law should be enacted to impose criminal penalties on the corporate deliberately killing or injuring a person by making reckless decisions. Finally, the government shall change the regulatory framework in a manner that validate that whether the safety check by the corpotrate having or capable of having informations on the products and their composing substances is adequate and sufficient or not...
August 1, 2016: Environmental Health and Toxicology
Vincent Kyere, Klaus Greve, Sampson Atiemo
Objectives: This study examined the spatial distribution and the extent of soil contamination by heavy metals resulting from the primitive, unconventional informal e-waste recycling in the Agbogbloshie e-waste processing site (AEPS) in Ghana. Method: 132 soil samples were collected at 100 m interval with the aid of a handheld GPS. Observing all procedural and quality assurance measures, the samples were analyzed for barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), nickel (Ni), lead (Pb) and zinc (Zn) heavy metals using an X - Ray fluorescence...
March 17, 2016: Environmental Health and Toxicology
Jong-Hyeon Lee
The humidifier disinfectant disaster (HDD) was not a simple poisoning accident by biocides, but a singular disaster in history created by chemicals in household products. This disaster was a result of the failure of a system for the management of chemical and product safety. Since the management authority for chemical usage safety is different from those for chemical safety in products, many blind areas for chemical safety management in products still remain. The 'Act on the Registration and Evaluation, etc...
2016: Environmental Health and Toxicology
Yong Min Cho, Hee Jin Lim, Hoon Jang, Kyunghee Kim, Jae Wook Choi, Chol Shin, Seung Ku Lee, Jong Hwa Kwon, Nam Kim
OBJECTIVES: This study analyzed the associations between mobile phone call frequency and duration with non-specific symptoms. METHODS: This study was conducted with a population group including 532 non-patient adults established by the Korean Genome and Epidemiology Study. The pattern of phone call using a mobile phone was investigated through face-to-face interview. Structured methods applied to quantitatively assess health effects are Headache Impact Test-6 (HIT-6), Psychosocial Well-being Index-Short Form, Beck Depression Inventory, Korean-Instrumental Activities of Daily Living, Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index, and 12-item Short Form Health Survey where a higher score represents a higher greater health effect...
2016: Environmental Health and Toxicology
Shinbum Kim, Sanghyuk Im, Youngeun Choi, Soomi Park, Jaesoon Hyun, Kyung Seok Lee, Sunimm Lee, Sung-Nan Lee, Jeongri Seo, Ju Hee Kim, Hyunsun Na, Minsun Kim
No abstract text is available yet for this article.
2016: Environmental Health and Toxicology
Amina Khatun, Sandipan Pal, Aloke Kumar Mukherjee, Palas Samanta, Subinoy Mondal, Debraj Kole, Priyanka Chandra, Apurba Ratan Ghosh
OBJECTIVES: The present study analyzes metal contamination in sediment of the East Kolkata Wetlands, a Ramsar site, which is receiving a huge amount of domestic and industrial wastewater from surrounding areas. The subsequent uptake and accumulation of metals in different macrophytes are also examined in regard to their phytoremediation potential. METHODS: Metals like cadmium (Cd), copper (Cu), manganese (Mn), and lead (Pb) were estimated in sediment, water and different parts of the macrophytes Colocasia esculenta and Scirpus articulatus...
2016: Environmental Health and Toxicology
Donguk Park
A total of 221 patients were evaluated to be humidifier disinfectant associated with lung injury (HDLI) through two rounds of programs through April 2015. The humidifier disinfectant (HD) brands most often associated with HDLI were found to be Oxy (n=151, 68 %) and Cefu (n=26, 17 %). Polyhexamethylene guanidine used for disinfectant for four types of HD brands including Oxy was found to be associated with the highest number of HDLI cases (n=188). Further programs are operating to identify various health effects including lung injury which may be associated with the use of HD...
2016: Environmental Health and Toxicology
Kawangsik Park
An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other organs has been conducted on this matter yet. So, an in-depth discussion on toxicological techniques is needed to determine whether or not PHMG is toxic to organs other than just the lungs. For the test of target organ toxicity by PHMG exposure, a toxicokinetic study must first be conducted. However, measurement method for PHMG injected into the body has not yet been established because it is not easy to analyze polymer PHMG, so related base studies on analytical technique for PHMG including radio-labeling chemistry must come first...
2016: Environmental Health and Toxicology
(no author information available yet)
No abstract text is available yet for this article.
2016: Environmental Health and Toxicology
Mijie Kim, Yong Joo Park, Huiyeon Ahn, Byeonghak Moon, Kyu Hyuck Chung, Seung Min Oh
OBJECTIVES: Aromatase inhibitors that block estrogen synthesis are a proven first-line hormonal therapy for postmenopausal breast cancer. Although it is known that standardized extract of Ginkgo biloba (EGb761) induces anti-carcinogenic effects like the aromatase inhibitors, the effects of EGb761 on steroidogenesis have not been studied yet. Therefore, the effects of EGb761 on steroidogenesis and aromatase activity was studied using a H295R cell model, which was a good in vitro model to predict effects on human adrenal steroidogenesis...
2016: Environmental Health and Toxicology
Hyeon-Yeong Kim
OBJECTIVES: A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both domestic and international references, examined the chemical management system, working environment, level of exposure, and possible associated risks. This information may be utilized in the future to determine appropriate exposure levels in working environments. METHODS: Hazard assessment was performed using chemical hazard information obtained from international agencies, such as Organization for Economic Cooperation and Development-generated Screening Information Data Set and International Program on Chemical Safety...
2016: Environmental Health and Toxicology
Yun-Chul Hong
A simple linear model to test the hypothesis based on one-on-one relationship has been used to find the causative factors of diseases. However, we now know that not just one, but many factors from different systems such as chemical exposure, genes, epigenetic changes, and proteins are involved in the pathogenesis of chronic diseases such as diabetes mellitus. So, with availability of modern technologies to understand the intricate nature of relations among complex systems, we need to move forward to the future by taking complex systems model...
2016: Environmental Health and Toxicology
Seung Hyuck Bang, Dong Jun Park, Yang-Hoon Kim, Jiho Min
OBJECTIVES: There have been developed to use targeting ability for antimicrobial, anticancerous, gene therapy and cosmetics through analysis of various membrane proteins isolated from cell organelles. METHODS: It was examined about the lysosomal membrane protein extracted from lysosome isolated from HeLa cell treated by 100 ppm melanin for 24 hours in order to find associated with targeting ability to melanin using by 2-dimensional electrophoresis. RESULTS: The result showed 14 up-regulated (1...
2016: Environmental Health and Toxicology
Yun-Keun Lee
OBJECTIVES: The aim of this study is to evaluate radiation exposure resulting from the comprehensive health examinations of selected university hospital programs and to present basic data for research and management strategies on the health effects of medical radiation exposure. METHODS: Radiation-based diagnostic studies of the comprehensive health examination programs of ten university hospitals in Seoul, Korea, as introduced in their websites, were analyzed. The medical radiation studies of the programs were reviewed by radiologists...
2016: Environmental Health and Toxicology
Yeonghee Kim
No abstract text is available yet for this article.
2016: Environmental Health and Toxicology
Yeyong Choi, Domyung Paek
Once released into the air, humidifier disinfectants became tiny nano-size particles, and resulted in chemical bronchoalveolitis. Families had lost their most beloved members, and even some of them became broken. Based on an estimate of two million potential victims who had experienced adverse effects from the use of humidifier disinfectants, we can say that what we have observed was only the tip of the iceberg. Problems of entire airways, as well as other systemic effects, should be examined, as we know these nano-size particles can irritate cell membranes and migrate into systemic circulation...
2016: Environmental Health and Toxicology
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