journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Oncology

journal
https://www.readbyqxmd.com/read/29354595/synergistic-rescue-of-nonsense-mutant-tumor-suppressor-p53-by-combination-treatment-with-aminoglycosides-and-mdm2-inhibitors
#1
Meiqiongzi Zhang, Angelos Heldin, Mireia Palomar-Siles, Susanne Öhlin, Vladimir J N Bykov, Klas G Wiman
The tumor suppressor gene TP53 is inactivated by mutation in a large fraction of human tumors. Around 10% of TP53 mutations are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional p53 protein. Aminoglycosides G418 (geneticin) and gentamicin have been shown to induce translational readthrough and expression of full-length p53. However, aminoglycosides have severe side effects that limit their clinical use. Here, we show that combination treatment with a proteasome inhibitor or compounds that disrupt p53-Mdm2 binding can synergistically enhance levels of full-length p53 upon aminoglycoside-induced readthrough of R213X nonsense mutant p53...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29326884/primary-orbital-melanoma-presentation-treatment-and-long-term-outcomes-for-13-patients
#2
Anna M Rose, Philip J Luthert, Channa N Jayasena, David H Verity, Geoffrey E Rose
Background: Periocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest origin), conjunctiva or orbit (rarest primary site). Melanoma accounts for 5-10% of metastatic/secondary orbital malignancies, but only a tiny proportion of primary orbital neoplasia. Primary orbital melanoma (POM) is exceedingly rare, with approximately 50 cases reported to date. Methods: All patients seen in the orbital unit at a tertiary referral hospital (1991-2016) with a biopsy-proven diagnosis of POM were identified from a diagnostic database and were studied...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29326883/metabolic-plasiticy-in-cancers-distinct-role-of-glycolytic-enzymes-gpi-ldhs-or-membrane-transporters-mcts
#3
REVIEW
Maša Ždralević, Ibtissam Marchiq, Monique M Cunha de Padua, Scott K Parks, Jacques Pouysségur
Research on cancer metabolism has recently re-surfaced as a major focal point in cancer field with a reprogrammed metabolism no longer being considered as a mere consequence of oncogenic transformation, but as a hallmark of cancer. Reprogramming metabolic pathways and nutrient sensing is an elaborate way by which cancer cells respond to high bioenergetic and anabolic demands during tumorigenesis. Thus, inhibiting specific metabolic pathways at defined steps should provide potent ways of arresting tumor growth...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29326882/the-role-of-class-ia-phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunits-in-glioblastoma
#4
REVIEW
Kevin J Pridham, Robin T Varghese, Zhi Sheng
Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) plays a critical role in the pathogenesis of cancer including glioblastoma, the most common and aggressive form of brain cancer. Targeting the PI3K pathway to treat glioblastoma has been tested in the clinic with modest effect. In light of the recent finding that PI3K catalytic subunits (PIK3CA/p110α, PIK3CB/p110β, PIK3CD/p110δ, and PIK3CG/p110γ) are not functionally redundant, it is imperative to determine whether these subunits play divergent roles in glioblastoma and whether selectively targeting PI3K catalytic subunits represents a novel and effective strategy to tackle PI3K signaling...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29322030/editorial-update-on-the-treatment-of-metastatic-non-small-cell-lung-cancer-nsclc-in-new-era-of-personalised-medicine
#5
EDITORIAL
Barbara Melosky
No abstract text is available yet for this article.
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29322029/influencing-cancer-screening-participation-rates-providing-a-combined-cancer-screening-program-a-one-stop-shop-could-be-a-potential-answer
#6
Amanda Bobridge, Kay Price, Tiffany K Gill, Anne W Taylor
Introduction: Participation in established cancer screening programs remains variable. Therefore, a renewed focus on how to increase screening uptake, including addressing structural barriers such as time, travel, and cost is needed. One approach could be the provision of combined cancer screening, where multiple screening tests are provided at the same time and location (essentially a 'One Stop' screening shop). This cohort study explored both cancer screening behavior and the acceptability of a combined screening approach...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29322028/high-content-monitoring-of-drug-effects-in-a-3d-spheroid-model
#7
Frédérique Mittler, Patricia Obeïd, Anastasia V Rulina, Vincent Haguet, Xavier Gidrol, Maxim Y Balakirev
A recent decline in the discovery of novel medications challenges the widespread use of 2D monolayer cell assays in the drug discovery process. As a result, the need for more appropriate cellular models of human physiology and disease has renewed the interest in spheroid 3D culture as a pertinent model for drug screening. However, despite technological progress that has significantly simplified spheroid production and analysis, the seeming complexity of the 3D approach has delayed its adoption in many laboratories...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29322027/allograft-for-myeloma-examining-pieces-of-the-jigsaw-puzzle
#8
REVIEW
Ehsan Malek, Najla El-Jurdi, Nicolaus Kröger, Marcos de Lima
Multiple myeloma (MM) cure remains elusive despite the availability of newer anti-myeloma agents. Patients with high-risk disease often suffer from early relapse and short survival. Allogeneic hematopoietic cell transplantation (allo-HCT) is an "immune-based" therapy that has the potential to offer long-term remission in a subgroup of patients, at the expense of high rates of transplant-related morbidity and mortality. Donor lymphocyte infusion (DLI) upon disease relapse after allo-HCT is able to generate an anti-myeloma response suggestive of a graft-versus-myeloma effect...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312890/editorial-uncovering-the-function-of-the-mitochondrial-protein-vdac-in-health-and-disease-from-structure-function-to-novel-therapeutic-strategies
#9
EDITORIAL
Varda Shoshan-Barmatz, Hanna Kmita, John J Lemasters
No abstract text is available yet for this article.
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312889/the-central-role-of-amino-acids-in-cancer-redox-homeostasis-vulnerability-points-of-the-cancer-redox-code
#10
REVIEW
Milica Vučetić, Yann Cormerais, Scott K Parks, Jacques Pouysségur
A fine balance in reactive oxygen species (ROS) production and removal is of utmost importance for homeostasis of all cells and especially in highly proliferating cells that encounter increased ROS production due to enhanced metabolism. Consequently, increased production of these highly reactive molecules requires coupling with increased antioxidant defense production within cells. This coupling is observed in cancer cells that allocate significant energy reserves to maintain their intracellular redox balance...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312888/straightening-beta-overdispersion-of-lethal-chromosome-aberrations-following-radiotherapeutic-doses-leads-to-terminal-linearity-in-the-alpha-beta-model
#11
Igor Shuryak, Bradford D Loucas, Michael N Cornforth
Recent technological advances allow precise radiation delivery to tumor targets. As opposed to more conventional radiotherapy-where multiple small fractions are given-in some cases, the preferred course of treatment may involve only a few (or even one) large dose(s) per fraction. Under these conditions, the choice of appropriate radiobiological model complicates the tasks of predicting radiotherapy outcomes and designing new treatment regimens. The most commonly used model for this purpose is the venerable linear-quadratic (LQ) formalism as it applies to cell survival...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312887/intraoperative-radiotherapy-for-breast-cancer
#12
REVIEW
Eleanor E R Harris, William Small
Intraoperative radiotherapy (IORT) for early stage breast cancer is a technique for partial breast irradiation. There are several technologies in clinical use to perform breast IORT. Regardless of technique, IORT generally refers to the delivery of a single dose of radiation to the periphery of the tumor bed in the immediate intraoperative time frame, although some protocols have performed IORT as a second procedure. There are two large prospective randomized trials establishing the safety and efficacy of breast IORT in early stage breast cancer patients with sufficient follow-up time on thousands of women...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312886/fluorescence-guided-surgery
#13
REVIEW
Tadanobu Nagaya, Yu A Nakamura, Peter L Choyke, Hisataka Kobayashi
Surgical resection of cancer remains an important treatment modality. Despite advances in preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate pathology with conventional white light imaging. Fluorescence-guided surgery (FGS) can be used to define tumor location and margins during the procedure. Intraoperative visualization of tumors may not only allow more complete resections but also improve safety by avoiding unnecessary damage to normal tissue which can also reduce operative time and decrease the need for second-look surgeries...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312885/guidelines-for-rational-cancer-therapeutics
#14
REVIEW
Byunghee Yoo, Ann-Marie Billig, Zdravka Medarova
Traditionally, cancer therapy has relied on surgery, radiation therapy, and chemotherapy. In recent years, these interventions have become increasingly replaced or complemented by more targeted approaches that are informed by a deeper understanding of the underlying biology. Still, the implementation of fully rational patient-specific drug design appears to be years away. Here, we present a vision of rational drug design for cancer that is defined by two major components: modularity and image guidance. We suggest that modularity can be achieved by combining a nanocarrier and an oligonucleotide component into the therapeutic...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312884/long-non-coding-rnas-in-prostate-cancer-with-emphasis-on-second-chromosome-locus-associated-with-prostate-1-expression
#15
REVIEW
Alessia Cimadamore, Silvia Gasparrini, Roberta Mazzucchelli, Andrea Doria, Liang Cheng, Antonio Lopez-Beltran, Matteo Santoni, Marina Scarpelli, Rodolfo Montironi
Long non-coding RNAs (lncRNAs) are a class of RNA with transcripts longer than 200 nucleotides that lack functional open reading frames. They play various roles in human carcinoma, such as dysregulating gene expression in prostate cancer (PCa), which results in cancer initiation, development, and progression. The non-coding RNA SChLAP1 (second chromosome locus associated with prostate-1) is highly expressed in approximately 25% of PCas with higher prevalence in metastatic compared to localized PCa. Its expression is detectable non-invasively in PCa patient urine samples...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312883/evolution-of-voltage-dependent-anion-channel-function-from-molecular-sieve-to-governator-to-actuator-of-ferroptosis
#16
John J Lemasters
The voltage-dependent anion channel (VDAC) is well known as the pathway for passive diffusion of anionic hydrophilic mitochondrial metabolites across the outer membrane, but a more complex functionality of the three isoforms of VDAC has emerged, as addressed in the Frontiers in Oncology Research Topic on "Uncovering the Function of the Mitochondrial Protein VDAC in Health and Disease: from Structure-Function to Novel Therapeutic Strategies." VDAC as the single most abundant protein in mitochondrial outer membranes is typically involved in isoform-specific interactions of the mitochondrion with its surroundings as, for example, during mitochondria-dependent pathways of cell death...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312882/future-directions-of-intraoperative-radiation-therapy-a-brief-review
#17
REVIEW
Tatjana Paunesku, Gayle E Woloschak
The use of intraoperative radiation therapy (IORT) is increasing with the development of new devices for patient treatment that allow irradiation without the need to move the patient from the surgical table. At the moment, ionizing radiation in the course of IORT is supported most often by the use of mobile devices that produce electrons, kilo voltage X-rays, and electronic brachytherapy and the development of applicators suitable for delivery of radionuclides for short-term brachytherapy. The establishment of new treatment devices and protocols that can be foreseen in the future, e...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312881/reactive-astrocytes-in-brain-metastasis
#18
REVIEW
David Wasilewski, Neibla Priego, Coral Fustero-Torre, Manuel Valiente
Brain metastasis, the secondary growth of malignant cells within the central nervous system (CNS), exceeds the incidence of primary brain tumors (i.e., gliomas) by tenfold and are seemingly on the rise owing to the emergence of novel targeted therapies that are more effective in controlling extracranial disease relatively to intracranial lesions. Despite the fact that metastasis to the brain poses a unmet clinical problem, with afflicted patients carrying significant morbidity and a fatal prognosis, our knowledge as to how metastatic cells manage to adapt to the tissue environment of the CNS remains limited...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29312880/evaluation-of-apoptosis-and-autophagy-inducing-potential-of-berberis-aristata-azadirachta-indica-and-their-synergistic-combinations-in-parental-and-resistant-human-osteosarcoma-cells
#19
Pracheta Sengupta, Sukanya Raman, Rajdeep Chowdhury, K Lohitesh, Heena Saini, Sudeshna Mukherjee, Atish Paul
Cancer is a multifactorial disease and hence can be effectively overcome by a multi-constituently therapeutic strategy. Medicinal plant extracts represent a perfect example of such stratagem. However, minimal studies have been done till date that portray the effect of extraction techniques on the phyto-constituent profile of plant extracts and its impact on anticancer activity. In the present study, we have evaluated the anticancer potential of methanolic extracts of Berberis aristata root and Azadirachta indica seeds prepared by various extraction techniques in human osteosarcoma (HOS) cells...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29276698/editorial-charged-particles-in-oncology
#20
EDITORIAL
Marco Durante, Francis A Cucinotta, Jay S Loeffler
No abstract text is available yet for this article.
2017: Frontiers in Oncology
journal
journal
43752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"