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Blood Cancer Journal

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https://www.readbyqxmd.com/read/28885613/microrna-155-regulates-casein-kinase-1-gamma-2-a-potential-pathogenetic-role-in-chronic-lymphocytic-leukemia
#1
T Zhang, J K Davidson-Moncada, P Mukherjee, R R Furman, E Bhavsar, Z Chen, P Hakimpour, N Papavasiliou, W Tam
No abstract text is available yet for this article.
September 8, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28885612/understanding-cd30-biology-and-therapeutic-targeting-a-historical-perspective-providing-insight-into-future-directions
#2
REVIEW
C A van der Weyden, S A Pileri, A L Feldman, J Whisstock, H M Prince
CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and Hodgkin lymphoma, among others. The variable expression of CD30 on both normal and malignant lymphoid cells has focused research efforts on understanding the pathogenesis of CD30 upregulation, its contribution to lymphomagenesis through anti-apoptotic mechanisms, and its effect on cell survival. Given the restriction of CD30 to certain tumor types, the logical extension of this has been to attempt to exploit it as a therapeutic target...
September 8, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28885611/secondary-acute-lymphoblastic-leukemia-is-a-distinct-clinical-entity-with-prognostic-significance
#3
A S Rosenberg, A Brunson, J K Paulus, J Tuscano, T Wun, T H M Keegan, B A Jonas
The effect of prior malignancy on the risk of developing, and prognosis of, acute lymphoblastic leukemia (ALL) is unknown. This observational study utilized the California Cancer Registry to estimate the risk of developing ALL after a prior malignancy using standardized incidence ratios (SIRs, 95% confidence intervals). ALL occurring after a malignancy with an SIR>1 (increased-risk (IR) malignancies) was considered secondary ALL (s-ALL). Adjusted hazard ratios (aHRs, 95% confidence intervals) compared the effect of s-ALL with de novo ALL on overall survival...
September 8, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28885610/in-silico-and-preclinical-drug-screening-identifies-dasatinib-as-a-targeted-therapy-for-t-all
#4
S Laukkanen, T Grönroos, P Pölönen, H Kuusanmäki, J Mehtonen, J Cloos, G Ossenkoppele, B Gjertsen, B Øystein, C Heckman, M Heinäniemi, M Kontro, O Lohi
No abstract text is available yet for this article.
September 8, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28862700/differences-in-genomic-patterns-and-clinical-outcomes-between-african-american-and-white-patients-with-myelodysplastic-syndromes
#5
A Nazha, K Al-Issa, B Przychodzen, N Abuhadra, C Hirsch, J P Maciejewski, M A Sekeres
No abstract text is available yet for this article.
September 1, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28862699/cxorf48-is-a-potential-therapeutic-target-for-achieving-treatment-free-remission-in-cml-patients
#6
M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori
Although the introduction of tyrosine kinase inhibitors (TKIs) has improved overall survival of patients with chronic myeloid leukemia (CML), about half of the patients eventually relapse after cessation of TKIs. In contrast, the remainder of the patients maintain molecular remission without TKIs, indicating that the patients' immune system could control proliferation of TKI-resistant leukemic stem cells (LSCs). However, the precise mechanism of immunity against CML-LSCs is not fully understood. We have identified a novel immune target, CXorf48, expressed in LSCs of CML patients...
September 1, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28862698/prognostic-implications-of-abnormalities-of-chromosome-13-and-the-presence-of-multiple-cytogenetic-high-risk-abnormalities-in-newly-diagnosed-multiple-myeloma
#7
M Binder, S V Rajkumar, R P Ketterling, P T Greipp, A Dispenzieri, M Q Lacy, M A Gertz, F K Buadi, S R Hayman, Y L Hwa, S R Zeldenrust, J A Lust, S J Russell, N Leung, P Kapoor, R S Go, W I Gonsalves, R A Kyle, S K Kumar
Fluorescence in situ hybridization evaluation is essential for initial risk stratification in multiple myeloma. While the presence of specific cytogenetic high-risk abnormalities (HRA) is known to confer a poor prognosis, less is known about the cumulative effect of multiple HRA. We studied 1181 patients with newly diagnosed multiple myeloma who received novel agents as first-line therapy. High-risk abnormalities were defined as t(4;14), t(14;16), t(14;20) and del(17p). There were 884 patients (75%) without any HRA and 297 patients (25%) with HRA, including 262 (22%) with one HRA and 35 (3%) with two HRA...
September 1, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841212/impact-of-notch-disruption-on-myeloid-development
#8
O L Francis, K K Chaudhry, T Lamprecht, J M Klco
No abstract text is available yet for this article.
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841211/whole-body-computed-tomography-versus-conventional-skeletal-survey-in-patients-with-multiple-myeloma-a-study-of-the-international-myeloma-working-group
#9
J Hillengass, L A Moulopoulos, S Delorme, V Koutoulidis, J Mosebach, T Hielscher, M Drake, S V Rajkumar, B Oestergaard, N Abildgaard, M Hinge, T Plesner, Y Suehara, K Matsue, N Withofs, J Caers, A Waage, H Goldschmidt, M A Dimopoulos, S Lentzsch, B Durie, E Terpos
For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841210/alternative-splicing-discriminates-molecular-subtypes-and-has-prognostic-impact-in-diffuse-large-b-cell-lymphoma
#10
S-K Leivonen, M Taskinen, A Cervera, M-L Karjalainen-Lindsberg, J Delabie, H Holte, R Lehtonen, S Hautaniemi, S Leppä
Effect of alternative splicing (AS) on diffuse large B-cell lymphoma (DLBCL) pathogenesis and survival has not been systematically addressed. Here, we compared differentially expressed genes and exons in association with survival after chemoimmunotherapy, and between germinal center B-cell like (GCB) and activated B-cell like (ABC) DLBCLs. Genome-wide exon array-based screen was performed from samples of 38 clinically high-risk patients who were treated in a Nordic phase II study with dose-dense chemoimmunotherapy and central nervous system prophylaxis...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841209/clonal-evolution-is-a-prognostic-factor-for-the-clinical-progression-of-monoclonal-b-cell-lymphocytosis
#11
I V Kostopoulos, G Paterakis, D Pavlidis, E Kastritis, E Terpos, O E Tsitsilonis, S I Papadhimitriou
No abstract text is available yet for this article.
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841208/clinical-features-and-outcomes-of-extramedullary-myeloid-sarcoma-in-the-united-states-analysis-using-a-national-data-set
#12
G Goyal, A C Bartley, M M Patnaik, M R Litzow, A Al-Kali, R S Go
No abstract text is available yet for this article.
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841207/vitamin-d-insufficiency-is-associated-with-an-increased-risk-of-early-clinical-failure-in-follicular-lymphoma
#13
S I Tracy, M J Maurer, T E Witzig, M T Drake, S M Ansell, G S Nowakowski, C A Thompson, D J Inwards, P B Johnston, I N Micallef, C Allmer, W R Macon, G J Weiner, S L Slager, T M Habermann, B K Link, J R Cerhan
We evaluated whether vitamin D insufficiency (VDI; 25(OH)D <20 ng/ml) was associated with adverse outcomes among follicular lymphoma (FL) patients using an observational prospective cohort study of 642 FL patients enrolled from 2002-2012. The median age at diagnosis was 60 years. At a median follow-up of 59 months, 297 patients (46%) had an event (progression, treatment failure), 78 had died and 42 (6.5%) had a lymphoma-related death. VDI was associated with inferior event-free survival (EFS) at 12 months (EFS12, odds ratio (OR)=2...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841206/overexpression-of-sox4-correlates-with-poor-prognosis-of-acute-myeloid-leukemia-and-is-leukemogenic-in-zebrafish
#14
J-W Lu, M-S Hsieh, H-A Hou, C-Y Chen, H-F Tien, L-I Lin
The SOX4 transcription factor is a key regulator of embryonic development, cell-fate decision, cellular differentiation and oncogenesis. Abnormal expression of SOX4 is related to malignant tumor transformation and cancer metastasis. However, no reports are available regarding the clinical significance of SOX4 in acute myeloid leukemia (AML) and the role of SOX4 in leukemogenesis. In the current study, we found that AML patients with low bone marrow (BM) SOX4 expression had higher remission rates and longer overall survival than those with high SOX4 expression, regardless of age, white blood cell count at diagnosis, karyotype profile and NPM1/FLT3-ITD status...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841205/revisiting-gene-mutations-and-prognosis-of-ex-m6a-acute-erythroid-leukemia-with-regard-to-the-new-who-classification
#15
N Cervera, N Carbuccia, M-J Mozziconacci, J Adélaïde, S Garnier, A Guille, A Murati, M Chaffanet, N Vey, D Birnbaum, V Gelsi-Boyer
No abstract text is available yet for this article.
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841204/from-waldenstr%C3%A3-m-s-macroglobulinemia-to-aggressive-diffuse-large-b-cell-lymphoma-a-whole-exome-analysis-of-abnormalities-leading-to-transformation
#16
C Jiménez, S Alonso-Álvarez, M Alcoceba, G R Ordóñez, M García-Álvarez, M I Prieto-Conde, M C Chillón, A Balanzategui, R Corral, L A Marín, N C Gutiérrez, N Puig, M E Sarasquete, M González, R García-Sanz
Transformation of Waldenström's macroglobulinemia (WM) to diffuse large B-cell lymphoma (DLBCL) occurs in up to 10% of patients and is associated with an adverse outcome. Here we performed the first whole-exome sequencing study of WM patients who evolved to DLBCL and report the genetic alterations that may drive this process. Our results demonstrate that transformation depends on the frequency and specificity of acquired variants, rather than on the duration of its evolution. We did not find a common pattern of mutations at diagnosis or transformation; however, there were certain abnormalities that were present in a high proportion of clonal tumor cells and conserved during this transition, suggesting that they have a key role as early drivers...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28841203/high-sensitivity-blood-based-m-protein-detection-in-scr-patients-with-multiple-myeloma
#17
J R Mills, D R Barnidge, A Dispenzieri, D L Murray
We assessed the ability of a mass spectrometry-based technique, called monoclonal immunoglobulin rapid accurate mass measurement (miRAMM), to extend the analytical range of M-protein detection in serum samples obtained from myeloma patients in stringent complete response (sCR) post-autologous stem cell transplant (ASCT). To aid the M-protein detection post ASCT, the accurate molecular mass of the M-protein light chain at diagnosis was determined in all patients (N=30) and used to positively identify clones in the sCR serum...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28753595/clinico-biological-significance-of-suppressor-of-cytokine-signaling-1-expression-in-acute-myeloid-leukemia
#18
H-A Hou, J-W Lu, T-Y Lin, C-H Tsai, W-C Chou, C-C Lin, Y-Y Kuo, C-Y Liu, M-H Tseng, Y-C Chiang, Y-L Peng, J-L Tang, Z Gong, L-I Lin, H-F Tien
Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. The mechanism of SOCS1 in tumor carcinogenesis is complex and there have been no studies concerning the clinic-biologic implication of SOCS1 expression in acute myeloid leukemia (AML). Here, we first identified that higher bone marrow (BM) SOCS1 expression was closely associated with older age, FLT3-ITD, NPM1 and DNMT3A mutations, but negatively correlated with CEBPA mutation in patients with de novo AML...
July 28, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28753594/the-first-in-class-alkylating-hdac-inhibitor-edo-s101-is-highly-synergistic-with-proteasome-inhibition-against-multiple-myeloma-through-activation-of-multiple-pathways
#19
L Besse, M Kraus, A Besse, J Bader, T Silzle, T Mehrling, C Driessen
No abstract text is available yet for this article.
July 28, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28731459/malignant-t-cells-activate-endothelial-cells-via-il-17%C3%A2-f
#20
B Lauenborg, I V Litvinov, Y Zhou, A Willerslev-Olsen, C M Bonefeld, C Nastasi, S Fredholm, L M Lindahl, D Sasseville, C Geisler, M M Wasik, T Krejsgaard, L M R Gjerdrum, L Iversen, N Odum, A Woetmann
No abstract text is available yet for this article.
July 21, 2017: Blood Cancer Journal
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