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International Journal of Breast Cancer

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https://www.readbyqxmd.com/read/27822389/beyond-dna-an-integrated-and-functional-approach-for-classifying-germline-variants-in-breast-cancer-genes
#1
REVIEW
T Pesaran, R Karam, R Huether, S Li, S Farber-Katz, A Chamberlin, H Chong, H LaDuca, A Elliott
Genetic testing for hereditary breast cancer is an integral part of individualized care in the new era of precision medicine. The accuracy of an assay is reliant on not only the technology and bioinformatics analysis utilized but also the experience and infrastructure required to correctly classify genetic variants as disease-causing. Interpreting the clinical significance of germline variants identified by hereditary cancer testing is complex and has a significant impact on the management of patients who are at increased cancer risk...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27800186/modified-lower-pole-autologous-dermal-sling-for-implant-reconstruction-in-women-undergoing-immediate-breast-reconstruction-after-mastectomy
#2
Pankaj G Roy
Background. Autologous dermal sling with wise pattern skin reducing mastectomy allows one-stage implant reconstruction in women with large and ptotic breasts needing mastectomy for cancer or risk reduction. However, this technique is not suitable for women who lack ptosis and also carries risk of T-junction breakdown. Method. We have performed one-stage nipple sparing mastectomies with implant reconstruction in 5 women (8 breasts) by modifying the autologous dermal sling approach. All these women had small to moderate breasts with no ptosis or pseudoptosis...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27800185/surgical-site-infections-in-breast-surgery-the-use-of-preoperative-antibiotics-for-elective-nonreconstructive-procedures
#3
Christopher B Crawford, James A Clay, Anna S Seydel, Jessica A Wernberg
Background. Antibiotic prophylaxis for surgical site infections (SSIs) for breast surgery is widespread, but the benefit in clean surgical cases is not well defined. Methods. A retrospective analysis of 855 patients undergoing elective, nonreconstructive breast operations was performed, with 401 patients receiving no antibiotics and 454 patients receiving a single dose of preoperative antibiotic. Results. Administration of a preoperative antibiotic did not decrease the SSI rate. In this community-based study, antibiotic use practices varied considerably by surgeon...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27660726/synthesis-structural-characterization-and-preclinical-efficacy-of-a-novel-paclitaxel-loaded-alginate-nanoparticle-for-breast-cancer-treatment
#4
Ahmed A Markeb, Nagwa A El-Maali, Douaa M Sayed, Amany Osama, Mohamed A Y Abdel-Malek, Amen H Zaki, Mostafa E A Elwanis, James J Driscoll
Purpose. The antitumor activity of a novel alginate (ALG) polymer-based particle that contained paclitaxel (PTX) was evaluated using human primary breast cancer cells. Materials and Methods. PTX was combined with ALG in a nanoparticle as a drug delivery system designed to improve breast cancer tumor cell killing. PTX-ALG nanoparticles were first synthesized by nanoemulsification polymer cross-linking methods that improved the aqueous solubility. Structural and biophysical properties of the PTX-ALG nanoparticles were then determined by transmission electron microscopy (TEM) and high performance liquid chromatography (HPLC) fluorescence...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27635263/pattern-of-breast-cancer-distribution-in-ghana-a-survey-to-enhance-early-detection-diagnosis-and-treatment
#5
Frank Naku Ghartey Jnr, Akwasi Anyanful, Sebastian Eliason, Saanid Mohammed Adamu, Samuel Debrah
Background. Nearly 70% of women diagnosed with breast cancer in Ghana are in advanced stages of the disease due especially to low awareness, resulting in limited treatment success and high death rate. With limited epidemiological studies on breast cancer in Ghana, the aim of this study is to assess and understand the pattern of breast cancer distribution for enhancing early detection and treatment. Methods. We randomly selected and screened 3000 women for clinical palpable breast lumps and used univariate and bivariate analysis for description and exploration of variables, respectively, in relation to incidence of breast cancer...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27525123/coverage-of-axillary-lymph-nodes-with-tangential-breast-irradiation-in-korea-a-multi-institutional-comparison-study
#6
Jinhong Jung, Moonkyoo Kong, Su Ssan Kim, Won Sup Yoon
Introduction. To evaluate the dose distribution and coverage of axilla using only tangential field for whole breast radiotherapy (RT) at three institutions in Korea. Methods. We used computed tomography (CT) images of nine consecutive 1-2 sentinel lymph node-positive patients who underwent breast conserving surgery and whole breast RT without axillary lymph node (ALN) dissection for clinical T1-2N0 breast cancer. The CT data were transferred to three radiation oncologists in 3 institutions and each radiation oncologist created treatment plans for all nine patients; a total of 27 treatment plans were analyzed...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27525122/advanced-imaging-and-receipt-of-guideline-concordant-care-in-women-with-early-stage-breast-cancer
#7
Elizabeth Trice Loggers, Diana S M Buist, Laura S Gold, Steven Zeliadt, Rachel Hunter Merrill, Ruth Etzioni, Scott D Ramsey, Sean D Sullivan, Larry Kessler
Objective. It is unknown whether advanced imaging (AI) is associated with higher quality breast cancer (BC) care. Materials and Methods. Claims and Surveillance Epidemiology and End Results data were linked for women diagnosed with incident stage I-III BC between 2002 and 2008 in western Washington State. We examined receipt of preoperative breast magnetic resonance imaging (MRI) or AI (defined as computed tomography [CT]/positron emission tomography [PET]/PET/CT) versus mammogram and/or ultrasound (M-US) alone and receipt of guideline concordant care (GCC) using multivariable logistic regression...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27413552/promoter-methylation-status-of-breast-cancer-susceptibility-gene-1-and-17-beta-hydroxysteroid-dehydrogenase-type-1-gene-in-sporadic-breast-cancer-patients
#8
Marwa M Hosny, Nagwan A Sabek, Taghrid B El-Abaseri, Fathalla M Hassan, Sherif H Farrag
Epigenetic modifications are involved in breast carcinogenesis. Identifying genes that are epigenetically silenced via methylation could select target patients for diagnostic as well as therapeutic potential. We assessed promoter methylation of breast cancer susceptibility gene 1 (BRCA1) and 17 Beta Hydroxysteroid Dehydrogenase Type 1 (17βHSD-1) in normal and cancer breast tissues of forty sporadic breast cancer (BC) cases using restriction enzyme based methylation-specific PCR (REMS-PCR). In cancerous tissues, BRCA1 and 17βHSD-1 were methylated in 42...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27413551/breast-cancer-in-africa-limitations-and-opportunities-for-application-of-genomic-medicine
#9
REVIEW
Allison Silverstein, Rachita Sood, Ainhoa Costas-Chavarri
As genomic medicine gains clinical applicability across a spectrum of diseases, insufficient application in low-income settings stands to increase health disparity. Breast cancer screening, diagnosis, and treatment have benefited greatly from genomic medicine in high-income settings. As breast cancer is a leading cause of both cancer incidence and mortality in Africa, attention and resources must be applied to research and clinical initiatives to integrate genomic medicine into breast cancer care. In terms of research, there is a paucity of investigations into genetic determinants of breast cancer specific to African populations, despite consensus in the literature that predisposition and susceptibility genes vary between populations...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27313897/associations-between-reoperations-and-psychological-factors-after-contralateral-risk-reducing-mastectomy-a-two-year-follow-up-study
#10
Dmytro Unukovych, Marie Wickman, Kerstin Sandelin, Brita Arver, Hemming Johansson, Yvonne Brandberg
Introduction. The aim of the study was to investigate associations between reoperations after contralateral risk-reducing mastectomies (CRRM) and emotional problems, body image, sexuality, and health related quality of life (HRQoL) in women with breast cancer and hereditary high risk. Patients and Methods. Patients scheduled for CRRM with breast reconstruction between 1998 and 2010 completed questionnaires, comprised of SF-36, the Hospital Anxiety and Depression Scale, the Body Image Scale, and the Sexual Activity Questionnaire, preoperatively and two years after CRRM...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27239346/unmet-supportive-care-needs-among-breast-cancer-survivors-of-community-based-support-group-in-kuching-sarawak
#11
Emmanuel Joseph Fong, Whye Lian Cheah
Background. Recognizing the needs of cancer survivors is one of the important aspects in healthcare delivery. This study aimed to determine the prevalence of unmet supportive care needs and its associated factors among the breast cancer survivors of community-based support group in Kuching, Sarawak. Materials and Methods. This was a cross-sectional study using Supportive Care Needs Survey (SCNS-SF34). All the members of community-based breast cancer support groups in Kuching were invited. A total of 101 respondents were face-to-face interviewed after the consent was obtained...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26942015/the-role-of-forkhead-box-protein-m1-in-breast-cancer-progression-and-resistance-to-therapy
#12
REVIEW
Raya Saba, Alhareth Alsayed, James P Zacny, Arkadiusz Z Dudek
The Forkhead box M1 (FOXM1) is a transcription factor that has been implicated in normal cell growth and proliferation through control of cell cycle transition and mitotic spindle. It is implicated in carcinogenesis of various malignancies where it is activated by either amplification, increased stability, enhanced transcription, dysfunction of regulatory pathways, or activation of PI3K/AKT, epidermal growth factor receptor, Raf/MEK/MAPK, and Hedgehog pathways. This review describes the role of FOXM1 in breast cancer...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26843988/quality-of-life-and-volume-reduction-in-women-with-secondary-lymphoedema-related-to-breast-cancer
#13
Marcus Lanza, Anke Bergmann, Maria Giseli da Costa Leite Ferreira, Suzana Sales de Aguiar, Ricardo de Almeida Dias, Karen de Souza Abrahão, Ester M Paltrinieri, Ruy G Martínez Allende, Mauro Figueiredo Carvalho de Andrade
Purpose. To assess the quality of life (QOL) as a predictor of volume reduction in women undergoing complex physical therapy (CPT) for lymphoedema following breast cancer. Methods. Clinical trial in 57 women undergoing CPT. Results. At baseline, in measuring quality of life for the EORTC QLQ-C30 questionnaire subscale of functionality, the worst scores for emotional function (55 points) and better social function (89 points) were observed. The symptom scales showed the worst pain averaged (66 points). The overall quality of life showed a low score (40 points)...
2015: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26783468/green-tea-catechin-egcg-suppresses-pcb-102-induced-proliferation-in-estrogen-sensitive-breast-cancer-cells
#14
Kimberly Mantzke Baker, Angela C Bauer
The persistence of polychlorinated biphenyls (PCBs) in the environment is of considerable concern since they accumulate in human breast tissue and may stimulate the growth of estrogen-sensitive tumors. Studies have shown that EGCG from green tea can modify estrogenic activity and thus may act as a cancer chemopreventive agent. In the present study, we evaluated the individual and combined effects of PCB 102 and EGCG on cell proliferation using an estrogen-sensitive breast cancer cell line MCF-7/BOS. PCB 102 (1-10 μM) increased cell proliferation in a dose-dependent manner...
2015: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26697229/preoperative-peripheral-blood-count-in-breast-carcinoma-predictor-of-prognosis-or-a-routine-test
#15
Amrit Pal Singh Rana, Manjit Kaur, B Zonunsanga, Arun Puri, Amarjit Singh Kuka
Background. Peripheral blood count is the first investigation to be done in every patient before surgery. As strong relationship exists between cancer and immune response of the body, clinical stage at presentation and altered hematological parameters can influence the progression of cancer and vice versa. Settings and Design. It is a case control study of total 50 cases (35 cases of carcinoma breast and 15 cases of benign breast disease). Methods. A case control study was carried out; 35 cases of breast cancer patients were taken prior to surgery and chemotherapy with 15 cases of benign breast disease as control...
2015: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26697228/assessment-of-pathological-response-of-breast-carcinoma-in-modified-radical-mastectomy-specimens-after-neoadjuvant-chemotherapy
#16
Dhanya Vasudevan, P S Jayalakshmy, Suresh Kumar, Siji Mathew
Aim. Paclitaxel based neoadjuvant chemotherapy regimen (NAT) in the setting of locally advanced breast cancer (LABC) can render inoperable tumor (T4, N2/N3) resectable. The aim of this study was to assess the status of carcinoma in the breast and lymph nodes after paclitaxel based NAT in order to find out the patient and the tumor characteristics that correspond to the pathological responses which could be used as a surrogate biomarker to assess the treatment response. Materials and Methods. Clinical and tumor characteristics of patients with breast carcinoma (n = 48) were assessed preoperatively...
2015: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26697227/a-nationwide-cross-sectional-survey-of-uk-breast-surgeons-views-on-the-management-of-ductal-carcinoma-in-situ
#17
Gurdeep S Mannu, Joao H Bettencourt-Silva, Farid Ahmed, Giles Cunnick
Background. There is wide variation in the management of Ductal Carcinoma In Situ (DCIS) nationwide. We aimed to investigate whether the attitudes of surgeons towards different aspects of DCIS treatment varied by seniority of surgeon or by geographical region within the UK. Materials and Methods. A nationwide online survey targeted at UK breast surgeons was undertaken. The anonymous survey contained questions regarding demographics of respondents and specific questions regarding DCIS management that were identified as areas of uncertainty during a systematic search of the literature...
2015: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26693355/c-reactive-protein-and-breast-cancer-new-insights-from-old-molecule
#18
REVIEW
Shilpa Balaji Asegaonkar, Balaji Narayanrao Asegaonkar, Unmesh Vidyadhar Takalkar, Suresh Advani, Anand Pandurang Thorat
Recently an association between breast cancer and inflammation has emerged as the seventh hallmark of cancer. Chronic inflammation is a key contributor in the development and progression of carcinogenesis. Inflammatory pathways play an important role in the causation of breast cancer. C-reactive protein (CRP) an acute-phase reactant inflammatory protein is synthesized in hepatocytes in response to cytokines that are released from leucocytes within the tumor microenvironment. Several epidemiological studies appraised an association of CRP with breast cancer risk with inconsistent findings...
2015: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26693354/synergistic-apoptotic-effect-of-crocin-and-paclitaxel-or-crocin-and-radiation-on-mcf-7-cells-a-type-of-breast-cancer-cell-line
#19
Faeze Vali, Vahid Changizi, Majid Safa
Background. Chemotherapy, radiotherapy, and surgery are routine treatments of breast cancer. However, these methods could only improve the living survival. Nowadays the combined therapy including herbals such as crocin is to study for improving breast cancer treatment. The purpose of this study was to evaluate the effects of crocin, paclitaxel, and radiation on MCF-7 cell. Methods. To evaluate the effect of crocin, paclitaxel, and radiation on survival rate of MCF-7 cells MTT assay was done. To investigate the apoptotic effect of experimental groups PI-flow cytometry was used and expression of apoptotic proteins (caspase-7, caspase-9, PARP, and p53) was studied by western blot...
2015: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/26635977/correlation-between-fine-needle-aspiration-cytology-and-histology-for-palpable-breast-masses-in-a-nigerian-tertiary-health-institution
#20
Adetola Olubunmi Daramola, Mosebolatan Olatokunboh Odubanjo, Fred John Obiajulu, Nzechukwu Zimudo Ikeri, Adekunbiola Aina Fehintola Banjo
Background. Management of breast lumps can be challenging in resource poor settings. Fine-needle aspiration cytology (FNAC) especially when used with cell block can help improve affordability for the patients. Objective. To determine the diagnostic accuracy of FNAC of palpable breast lesions within a 5-year period. Methods. The findings obtained from FNAC of palpable breast lumps seen at the FNAC clinic of our department from January 2007 to December 2011 were retrieved and correlated with findings on histology of excisional biopsies...
2015: International Journal of Breast Cancer
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