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International Journal of Breast Cancer

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https://www.readbyqxmd.com/read/30057821/prevention-of-acute-radiation-induced-skin-reaction-with-npe%C3%A2-camellia-sinensis-nonfermentatum-extract-in-female-breast-cancer-patients-undergoing-postoperative-radiotherapy-a-single-centre-prospective-open-label-pilot-study
#1
Gabriela Näf, Urs E Gasser, Hans E Holzgang, Sandra Schafroth, Christoph Oehler, Daniel R Zwahlen
Background: To assess effectiveness of NPE, a proprietary Camellia sinensis nonfermentatum (CSNF) extract, in prevention and recovery of acute radiation-induced skin reaction (ARSR) and skin care during postoperative whole breast radiotherapy (RT). Methods: Twenty patients were enrolled in this single centre, prospective, open-label pilot study. The outcomes of 20 prospective data sets were compared with 100 retrospectively collected matched data sets derived from hospital records...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/30018827/overcoming-therapeutic-resistance-of-triple-positive-breast-cancer-with-cdk4-6-inhibition
#2
REVIEW
Troy B Schedin, Virginia F Borges, Elena Shagisultanova
Triple positive breast cancers overexpress both the human epidermal growth factor receptor 2 (HER2) oncogene and the hormonal receptors (HR) to estrogen and progesterone. These cancers represent a unique therapeutic challenge because of a bidirectional cross-talk between the estrogen receptor alpha (ER α ) and HER2 pathways leading to tumor progression and resistance to targeted therapy. Attempts to combine standard of care HER2-targeted drugs with antihormonal agents for the treatment of HR+/HER2+ breast cancer yielded encouraging results in preclinical experiments but did improve overall survival in clinical trial...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/30009057/concordance-between-immunohistochemistry-and-microarray-gene-expression-profiling-for-estrogen-receptor-progesterone-receptor-and-her2-receptor-statuses-in-breast-cancer-patients-in-lebanon
#3
Ghina B Fakhri, Reem S Akel, Maya K Khalil, Deborah A Mukherji, Fouad I Boulos, Arafat H Tfayli
Introduction: Accurate evaluation of estrogen and progesterone receptors and HER2 is critical when diagnosing invasive breast cancer for optimal treatment. The current evaluation method is via immunohistochemistry (IHC). In this paper, we compared results of ER, PR, and HER2 from microarray gene expression to IHC in 81 fresh breast cancer specimens. Methods: Gene expression profiling was performed using the GeneChip Human Genome U133 Plus 2.0 arrays (Affymetrix Inc)...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29984003/personalizing-radiation-treatment-delivery-in-the-management-of-breast-cancer
#4
REVIEW
Kamran A Ahmed, G Daniel Grass, Amber G Orman, Casey Liveringhouse, Michael E Montejo, Hatem H Soliman, Heather S Han, Brian J Czerniecki, Javier F Torres-Roca, Roberto Diaz
Long-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In this review, we discuss our efforts to personalize radiotherapy dosing using genomic data and the implications for future clinical trials. We also explore immune mechanisms that may contribute to a tumor's unique radiation sensitivity or resistance...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29967698/the-impact-of-locoregional-therapy-in-nonmetastatic-inflammatory-breast-cancer-a-population-based-study
#5
Mahvish Muzaffar, Helen M Johnson, Nasreen A Vohra, Darla Liles, Jan H Wong
Background: Inflammatory breast cancer (IBC) is a rare but most aggressive breast cancer subtype. The impact of locoregional therapy on survival in IBC is controversial. Methods: Patients with nonmetastatic IBC between 1988 and 2013 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. Results: We identified 7,304 female patients with nonmetastatic inflammatory breast cancer (IBC) who underwent primary tumor surgery...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29862084/precision-medicine-for-breast-cancer-the-paths-to-truly-individualized-diagnosis-and-treatment
#6
REVIEW
Eleanor E R Harris
Precision medicine in oncology seeks to individualize each patient's treatment regimen based on an accurate assessment of the risk of recurrence or progression of that person's cancer. Precision will be achieved at each phase of care, from detection to diagnosis to surgery, systemic therapy, and radiation therapy, to survivorship and follow-up care. The precision arises from detailed knowledge of the inherent biological propensities of each tumor, rather than generalizing treatment approaches based on phenotypic, or even genotypic, categories...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29862083/the-evolution-of-radiation-therapy-in-metastatic-breast-cancer-from-local-therapy-to-systemic-agent
#7
REVIEW
Jessica M S Jutzy, Jeffrey M Lemons, Jason J Luke, Steven J Chmura
Radiation therapy is a mainstay of treatment in early and locally advanced breast cancer but is typically reserved for palliation of symptomatic lesions in patients with metastatic breast cancer. With new advances in the field of tumor biology and immunology, the role of radiation in the metastatic setting is evolving to harness its immune-enhancing properties. Through the release of tumor antigens, tumor DNA, and cytokines into the tumor microenvironment, radiation augments the antitumoral immune response to affect both the targeted lesion and distant sites of metastatic disease...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29850259/safety-assessment-of-neoadjuvant-pertuzumab-combined-with-trastuzumab-in-nonmetastatic-her2-positive-breast-cancer-in-postmenopausal-elderly-women-of-south-asia
#8
Nadia Hussain, Amira S A Said, Zainab Khan
Aim: To evaluate the safety issues and adverse effects of using TCHP regimen (docetaxel, carboplatin, trastuzumab, and pertuzumab) versus TCP regimen (docetaxel, carboplatin, and trastuzumab) in older postmenopausal women with nonmetastatic HER2-positive breast cancer. HER2 overexpressed in 20-25% of breast cancer signals an aggressive form of breast cancer and is treated with trastuzumab and pertuzumab. Methods: The patient record database was accessed to identify all postmenopausal women in the Punjab Care hospital who were above 65 years old, with stages 1-3 HER2-positive breast cancer and treated with neoadjuvant TCHP and neoadjuvant TCP from 2013 till 2016...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29850258/breast-i-is-an-effective-and-reliable-adjunct-screening-tool-for-detecting-early-tumour-related-angiogenesis-of-breast-cancers-in-low-resource-sub-saharan-countries
#9
Frank Naku Ghartey, David Watmough, Samuel Debrah, Martin Morna, Akwasi Anyanful
Background: What cheaper alternative breast screening procedures are available to younger women in addition to clinical breast examination (CBE) in Sub-Saharan countries? In 2009, we first described BreastLight for screening and reported high sensitivity at detecting breast cancer. Due to limitations of BreastLight, we have since 2014 been using the more technologically advanced Breast-i to screen 2204 women to find cheaper screening alternatives. Methodology: First, the participant lies down for CBE and then, in a darkened room, Breast-i was placed underneath each breast and trained personnel confirm vein pattern and look out for dark spot(s) to ascertain the presence of suspicious angiogenic lesion(s)...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29686906/postmastectomy-radiation-therapy-are-we-ready-to-individualize-radiation
#10
REVIEW
Ashlyn S Everett, Drexell Hunter Boggs, Jennifer F De Los Santos
Contemporary recommendations for postmastectomy radiation have undergone a shift in thinking away from simple stage based recommendations (one size fits all) to a system that considers both tumor biology and host factors. While surgical staging has traditionally dictated indications for postmastectomy radiation therapy (PMRT), our current understanding of tumor biology, host, immunoprofiles, and tumor microenvironment may direct a more personalized approach to radiation. Understanding the interaction of these variables may permit individualization of adjuvant therapy aimed at appropriate escalation and deescalation, including recommendations for PMRT...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29576883/rate-of-clinical-complete-response-for-1-year-or-more-in-bone-metastatic-breast-cancer-after-comprehensive-treatments-including-autologous-formalin-fixed-tumor-vaccine
#11
Fumito Kuranishi, Yuki Imaoka, Yuusuke Sumi, Yoji Uemae, Hiroko Yasuda-Kurihara, Takeshi Ishihara, Tsubasa Miyazaki, Tadao Ohno
Introduction: No effective treatment has been developed for bone-metastatic breast cancer. We found 3 cases with clinical complete response (cCR) of the bone metastasis and longer overall survival of the retrospectively examined cohort treated comprehensively including autologous formalin-fixed tumor vaccine (AFTV). Patients and Methods: AFTV was prepared individually for each patient from their own formalin-fixed and paraffin-embedded breast cancer tissues. Results: Three patients maintained cCR status of the bone metastasis for 17 months or more...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29507815/the-use-of-sentinel-lymph-node-biopsy-in-brca1-2-mutation-carriers-undergoing-prophylactic-mastectomy-a-retrospective-consecutive-case-series-study
#12
Sara Câmara, Daniela Pereira, Saudade André, Beatriz Mira, Fátima Vaz, Rodrigo Oom, José Carlos Marques, João Leal de Faria, Catarina Rodrigues Dos Santos
Introduction: Sentinel lymph node biopsy in prophylactic mastectomy is controversial. It avoids lymphadenectomy in occult carcinoma but is associated with increased morbidity. Women with BRCA mutations have a higher incidence of occult carcinoma and our objective was to assess the clinical utility of sentinel lymph node biopsy when these women undergo prophylactic mastectomy. Materials and Methods: Seven-year retrospective consecutive case-series study of women, with a BRCA deleterious mutation, admitted to prophylactic mastectomy, at our center...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29484211/establishing-the-role-of-stereotactic-ablative-body-radiotherapy-in-early-stage-breast-cancer
#13
REVIEW
Aisling Barry, Anthony Fyles
Stereotactic ablative body radiotherapy (SABR) has a role as definitive therapy in many tumor sites; however, its role in the treatment of breast cancer is less well explored. Currently, SABR has been investigated in the neoadjuvant and adjuvant setting with a number of ongoing feasibility studies. However, its use comes with a number of radiobiological and technical challenges that require further evaluation. We have learned much from other extracranial disease sites such as lung, brain, and spine, where definitive treatment with SABR has shown encouraging outcomes...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29348942/molecular-signatures-of-radiation-response-in-breast-cancer-towards-personalized-decision-making-in-radiation-treatment
#14
REVIEW
Corey Speers, Lori J Pierce
Recent advances in gene expression profiling have allowed for a more sophisticated understanding of the biology of breast cancers. These advances led to the development of molecular signatures that now allow clinicians to more individually tailor recommendations regarding the utility and necessity of systemic therapies for women with breast cancer. Indeed, these molecularly based tests have been incorporated into national and international best practice guidelines and are now part of routine practice. Similar, though slower, progress is being made in the development of molecular signatures predictive of radiation response and necessity for women with breast cancer...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29348941/the-immunoexpression-of-glucocorticoid-receptors-in-breast-carcinomas-lactational-change-and-normal-breast-epithelium-and-its-possible-role-in-mammary-carcinogenesis
#15
Raja Alyusuf, Javed Fayyaz Wazir, Urmil Prabha Brahmi, Abdul Rahman Fakhro, Moiz Bakhiet
The role of estrogen and progesterone receptors in breast cancer biology is well established. In contrast, other steroid hormones are less well studied. Glucocorticoids (GCs) are known to play a role in mammary development and differentiation; thus, it is of interest to attempt to delineate their immunoexpression across a spectrum of mammary epithelia. Aim . To delineate the distribution pattern of glucocorticoid receptors (GRs) in malignant versus nonmalignant epithelium with particular emphasis on lactational epithelium...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29333297/metronomic-chemotherapy-in-triple-negative-metastatic-breast-cancer-the-future-is-now
#16
REVIEW
M E Cazzaniga, L Cortesi, A Ferzi, L Scaltriti, F Cicchiello, M Ciccarese, S Della Torre, F Villa, M Giordano, C Verusio, M Nicolini, A R Gambaro, L Zanlorenzi, E Biraghi, E Casini, L Legramandi, E Rulli
Triple-negative breast cancer (TNBC) shows a very bad prognosis, even in early stages of disease. Metronomic chemotherapy refers to the minimum biologically effective dose of a chemotherapy agent given as a continuous dosing regimen with no prolonged drug-free breaks that leads to antitumor activity. In the present article, we review preclinical and clinical data of metronomic administration of chemotherapy agents with or without biological agents in TNBC cell lines and patients, contextually reporting data from the VICTOR-2 study in the subgroup of patients with TNBC, in order to stimulate new ideas for the design of clinical trials in this subset of patients...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29201466/breast-cancer-status-in-iran-statistical-analysis-of-3010-cases-between-1998-and-2014
#17
Mohammad Esmaeil Akbari, Soheila Sayad, Saed Sayad, Maryam Khayamzadeh, Leila Shojaee, Zeynab Shormeji, Mojtaba Amiri
Background: Breast cancer is the 5th leading cause of cancer death in Iranian women. This study analyzed 3010 women with breast cancer that had been referred to a cancer research center in Tehran between 1998 and 2014. Methods: In this retrospective study, we analyzed 3010 breast cancer cases with 32 clinical and paraclinical attributes. We checked the data quality rigorously and removed any invalid values or records. The method was data mining (problem definition, data preparation, data exploration, modeling, evaluation, and deployment)...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29147583/patterns-of-progression-in-metastatic-estrogen-receptor-positive-breast-cancer-an-argument-for-local-therapy
#18
Patrick Kelly, Zhe Ma, Said Baidas, Rebecca Moroose, Nikita Shah, Roi Dagan, Eleftherios Mamounas, Justin Rineer
Purpose: Despite advances in endocrine therapy (ET), metastatic estrogen receptor positive breast cancer (BrCA) remains incurable. Though the mechanisms of resistance to ET have been studied extensively, the anatomic pattern of disease progression remains poorly characterized. The purpose of this study was to characterize the pattern of progression for patients receiving ET for metastatic BrCA. Methods: The records of 108 patients with metastatic BrCA who progressed on ET were reviewed...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29130001/are-patients-traveling-for-intraoperative-radiation-therapy
#19
Kelsey E Larson, Stephanie A Valente, Chirag Shah, Rahul D Tendulkar, Sheen Cherian, Courtney Yanda, Chao Tu, Jessica Echle, Stephen R Grobmyer
Purpose: One benefit of intraoperative radiation therapy (IORT) is that it usually requires a single treatment, thus potentially eliminating distance as a barrier to receipt of whole breast irradiation. The aim of this study was to evaluate the distance traveled by IORT patients at our institution. Methods: Our institutional prospective registry was used to identify IORT patients from 10/2011 to 2/2017. Patient's home zip code was compared to institution zip code to determine travel distance...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28912973/clinical-characteristics-in-patients-with-triple-negative-breast-cancer
#20
Janet Yeh, Jennifer Chun, Shira Schwartz, Annie Wang, Elizabeth Kern, Amber A Guth, Deborah Axelrod, Richard Shapiro, Freya Schnabel
PURPOSE: The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. METHODS: Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016. RESULTS: Out of a total of 1964 patients, 190 (10%) patients had TNBC...
2017: International Journal of Breast Cancer
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