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International Journal of Breast Cancer

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https://www.readbyqxmd.com/read/28698809/p-rex1-expression-in-invasive-breast-cancer-in-relation-to-receptor-status-and-distant-metastatic-site
#1
Jonathan D Marotti, Kristen E Muller, Laura J Tafe, Eugene Demidenko, Todd W Miller
BACKGROUND: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-Rex1) has been implicated in cancer growth, metastasis, and response to phosphatidylinositol 3-kinase (PI3K) inhibitor therapy. The aim of this study was to determine whether P-Rex1 expression differs between primary and metastatic human breast tumors and between breast cancer subtypes. DESIGN: P-Rex1 expression was measured in 133 specimens by immunohistochemistry: 40 and 42 primary breast tumors from patients who did versus did not develop metastasis, respectively, and 51 breast-derived tumors from metastatic sites (36 of which had matching primary tumors available for analysis)...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28607775/obesity-and-prognostic-variables-in-colombian-breast-cancer-patients-a-cross-sectional-study
#2
Javier Cuello-López, Ana Fidalgo-Zapata, Elsa Vásquez-Trespalacios
INTRODUCTION: Obesity is an established risk factor for cancer and cancer-related deaths, including that of the breast. While the prevalence of female obesity has accelerated over the past decade in many developing countries, such as Colombia, the prevalence of overweight and obesity specifically in breast cancer populations has not been fully described. METHODS: A cross-sectional study including 849 women diagnosed with breast cancer between 2009 and 2014. Based on body mass index, prevalence of overweight (BMI ≥ 25 < 30) and obesity (BMI ≥ 30) and associations of BMI with clinical and tumor histopathological features were analyzed...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28596921/practices-of-breast-self-examination-and-associated-factors-among-female-debre-berhan-university-students
#3
Kalayu Birhane, Miskir Alemayehu, Belayneh Anawte, Gebru Gebremariyam, Ruth Daniel, Semeneh Addis, Teshome Worke, Abdurrahman Mohammed, Wassie Negash
BACKGROUND: Breast cancer is the most prevalent form of cancer in Ethiopia of all female cancers. It is considered to be a progressive disease with a poor prognosis if detected late. Breast self-examination is an important prevention method of breast cancer. This study was aimed at assessing practice and associated factors of breast self-examination (BSE) among female Debre Berhan University students in Ethiopia. METHODS: A cross-sectional study was conducted in 2015 among 420 using self-administrated questionnaire...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28567307/corrigendum-to-unmet-supportive-care-needs-among-breast-cancer-survivors-of-community-based-support-group-in-kuching-sarawak
#4
Emmanuel Joseph Fong, Whye Lian Cheah
[This corrects the article DOI: 10.1155/2016/7297813.].
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28487775/the-landscape-of-randomised-controlled-trials-of-therapies-in-breast-cancer-in-low-and-middle-income-countries
#5
REVIEW
Katharine Lynch-Kelly, Matthew Singer, Norman R Williams
Objectives. The objectives of this study were to identify the randomised controlled trials in breast cancer occurring in low and middle income countries (LMICs) generally and within Sub-Saharan Africa specifically, to describe the current status and identify opportunities for further research in these areas. Materials and Methods. Data for this study were obtained from ClinicalTrials.gov. The search term "Breast Cancer Research" was used, and relevant information extracted and analysed. Results. 2414 trials were identified, of which 1099 were eligible for inclusion...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28286675/ductal-breast-carcinoma-in-situ-mammographic-features-and-its-relation-to-prognosis-and-tumour-biology-in-a-population-based-cohort
#6
Wenjing Zhou, Thomas Sollie, Tibor Tot, Carl Blomqvist, Shahin Abdsaleh, Göran Liljegren, Fredrik Wärnberg
Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabár. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral (IBE) in situ and invasive events...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28182100/semaphorin-3a-increases-fak-phosphorylation-at-focal-adhesions-to-modulate-mda-mb-231-cell-migration-and-spreading-on-different-substratum-concentrations
#7
Scott Gehler, Frances V Compere, Alex M Miller
Interactions between integrin-mediated adhesions and the extracellular matrix (ECM) are important regulators of cell migration and spreading. However, mechanisms by which extracellular ligands regulate cell migration and spreading in response to changes in substratum concentration are not well understood. Semaphorin 3A (Sema3A) has been shown to inhibit cell motility and alter integrin signaling in various cell types. We propose that Sema3A alters focal adhesions to modulate breast carcinoma cell migration and spreading on substrata coated with different concentrations of ECM...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28168059/quality-of-breast-cancer-information-on-the-internet-by-african-organizations-an-appraisal
#8
REVIEW
Cynthia Pomaa Akuoko
Objective. The aim of this study was to appraise the quality of information on BC available at websites run by organizations in Africa. Methods. Three searches were conducted using Google search engine to generate a list of websites. The identified websites were assessed using European Commission (EC) quality criteria for health-related websites, which comprises different assessment areas including, completeness, transparency and honesty, authority, privacy and data protection, updating of information, accountability, and accessibility...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28168058/correlation-of-oncotype-dx-recurrence-score-with-histomorphology-and-immunohistochemistry-in-over-500-patients
#9
Matthew G Hanna, Ira J Bleiweiss, Anupma Nayak, Shabnam Jaffer
Oncotype Dx is used to determine the recurrence risk (RR) in patients with estrogen receptor positive (ER+) and lymph node negative (LN-) breast cancer. The RR is divided into low (0-17), intermediate (18-30), and high (31) to predict chemotherapy benefit. Our goal was to determine the association between histomorphology, immunohistochemistry, and RR. We retrospectively identified 536 patients with ER+ and LN- breast cancers that underwent Oncotype testing from 2006 to 2013. Tumor size ranged from 0.2 cm to 6...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28116166/a-nationwide-survey-of-uk-oncologists-views-on-the-choice-of-radiotherapy-regime-for-the-reconstructed-chest-wall-in-breast-cancer-patients
#10
Nicola Davis, Rema Jyothirmayi
Aims. This paper describes a UK survey of the choice of radiotherapy regime for the reconstructed chest wall in breast cancer patients. Questions focused on which fractionation regime consultants choose, their reasons for this, whether the type of reconstruction influences their choice, and whether bolus is used in patients who have undergone immediate reconstructive surgery. Materials and Methods. Between July 2014 and July 2015 a survey was sent by email to UK consultant radiation oncologists treating breast cancer...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28078143/breast-cancer-profile-among-patients-with-a-history-of-chemoprevention
#11
Freya R Schnabel, Sarah Pivo, Jennifer Chun, Shira Schwartz, Ana Paula Refinetti, Deborah Axelrod, Amber Guth
Purpose. This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease. Methods. Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided into primary (no history of breast cancer) and secondary (previous history of breast cancer) groups and compared to patients who never took chemoprevention. Results. 135 (6%) of 2430 women used chemoprevention. In the primary chemoprevention group (n = 18, 1%), 39% had completed >5 years of treatment, and fully 50% were on treatment at time of diagnosis...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28070424/a-matched-case-control-study-of-risk-factors-for-breast-cancer-risk-in-vietnam
#12
J Nguyen, Q H Le, B H Duong, P Sun, H T Pham, V T Ta, J Kotsopoulos, S A Narod, O Ginsburg
Background. Vietnam has a low age-standardized incidence of breast cancer, but the incidence is rising rapidly with economic development. We report data from a matched case-control study of risk factors for breast cancer in the largest cancer hospital in Vietnam. Methods. 492 incident breast cancer cases unselected for family history or age at diagnosis and 1306 control women age 25-75 were recruited from the National Cancer Hospital (BVK), Hanoi. Structured interviews were conducted and pathology data was centrally reported at the National Cancer Hospital of Vietnam, in Hanoi...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27822389/beyond-dna-an-integrated-and-functional-approach-for-classifying-germline-variants-in-breast-cancer-genes
#13
REVIEW
T Pesaran, R Karam, R Huether, S Li, S Farber-Katz, A Chamberlin, H Chong, H LaDuca, A Elliott
Genetic testing for hereditary breast cancer is an integral part of individualized care in the new era of precision medicine. The accuracy of an assay is reliant on not only the technology and bioinformatics analysis utilized but also the experience and infrastructure required to correctly classify genetic variants as disease-causing. Interpreting the clinical significance of germline variants identified by hereditary cancer testing is complex and has a significant impact on the management of patients who are at increased cancer risk...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27800186/modified-lower-pole-autologous-dermal-sling-for-implant-reconstruction-in-women-undergoing-immediate-breast-reconstruction-after-mastectomy
#14
Pankaj G Roy
Background. Autologous dermal sling with wise pattern skin reducing mastectomy allows one-stage implant reconstruction in women with large and ptotic breasts needing mastectomy for cancer or risk reduction. However, this technique is not suitable for women who lack ptosis and also carries risk of T-junction breakdown. Method. We have performed one-stage nipple sparing mastectomies with implant reconstruction in 5 women (8 breasts) by modifying the autologous dermal sling approach. All these women had small to moderate breasts with no ptosis or pseudoptosis...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27800185/surgical-site-infections-in-breast-surgery-the-use-of-preoperative-antibiotics-for-elective-nonreconstructive-procedures
#15
Christopher B Crawford, James A Clay, Anna S Seydel, Jessica A Wernberg
Background. Antibiotic prophylaxis for surgical site infections (SSIs) for breast surgery is widespread, but the benefit in clean surgical cases is not well defined. Methods. A retrospective analysis of 855 patients undergoing elective, nonreconstructive breast operations was performed, with 401 patients receiving no antibiotics and 454 patients receiving a single dose of preoperative antibiotic. Results. Administration of a preoperative antibiotic did not decrease the SSI rate. In this community-based study, antibiotic use practices varied considerably by surgeon...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27660726/synthesis-structural-characterization-and-preclinical-efficacy-of-a-novel-paclitaxel-loaded-alginate-nanoparticle-for-breast-cancer-treatment
#16
Ahmed A Markeb, Nagwa A El-Maali, Douaa M Sayed, Amany Osama, Mohamed A Y Abdel-Malek, Amen H Zaki, Mostafa E A Elwanis, James J Driscoll
Purpose. The antitumor activity of a novel alginate (ALG) polymer-based particle that contained paclitaxel (PTX) was evaluated using human primary breast cancer cells. Materials and Methods. PTX was combined with ALG in a nanoparticle as a drug delivery system designed to improve breast cancer tumor cell killing. PTX-ALG nanoparticles were first synthesized by nanoemulsification polymer cross-linking methods that improved the aqueous solubility. Structural and biophysical properties of the PTX-ALG nanoparticles were then determined by transmission electron microscopy (TEM) and high performance liquid chromatography (HPLC) fluorescence...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27635263/pattern-of-breast-cancer-distribution-in-ghana-a-survey-to-enhance-early-detection-diagnosis-and-treatment
#17
Frank Naku Ghartey Jnr, Akwasi Anyanful, Sebastian Eliason, Saanid Mohammed Adamu, Samuel Debrah
Background. Nearly 70% of women diagnosed with breast cancer in Ghana are in advanced stages of the disease due especially to low awareness, resulting in limited treatment success and high death rate. With limited epidemiological studies on breast cancer in Ghana, the aim of this study is to assess and understand the pattern of breast cancer distribution for enhancing early detection and treatment. Methods. We randomly selected and screened 3000 women for clinical palpable breast lumps and used univariate and bivariate analysis for description and exploration of variables, respectively, in relation to incidence of breast cancer...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27525123/coverage-of-axillary-lymph-nodes-with-tangential-breast-irradiation-in-korea-a-multi-institutional-comparison-study
#18
Jinhong Jung, Moonkyoo Kong, Su Ssan Kim, Won Sup Yoon
Introduction. To evaluate the dose distribution and coverage of axilla using only tangential field for whole breast radiotherapy (RT) at three institutions in Korea. Methods. We used computed tomography (CT) images of nine consecutive 1-2 sentinel lymph node-positive patients who underwent breast conserving surgery and whole breast RT without axillary lymph node (ALN) dissection for clinical T1-2N0 breast cancer. The CT data were transferred to three radiation oncologists in 3 institutions and each radiation oncologist created treatment plans for all nine patients; a total of 27 treatment plans were analyzed...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27525122/advanced-imaging-and-receipt-of-guideline-concordant-care-in-women-with-early-stage-breast-cancer
#19
Elizabeth Trice Loggers, Diana S M Buist, Laura S Gold, Steven Zeliadt, Rachel Hunter Merrill, Ruth Etzioni, Scott D Ramsey, Sean D Sullivan, Larry Kessler
Objective. It is unknown whether advanced imaging (AI) is associated with higher quality breast cancer (BC) care. Materials and Methods. Claims and Surveillance Epidemiology and End Results data were linked for women diagnosed with incident stage I-III BC between 2002 and 2008 in western Washington State. We examined receipt of preoperative breast magnetic resonance imaging (MRI) or AI (defined as computed tomography [CT]/positron emission tomography [PET]/PET/CT) versus mammogram and/or ultrasound (M-US) alone and receipt of guideline concordant care (GCC) using multivariable logistic regression...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27413552/promoter-methylation-status-of-breast-cancer-susceptibility-gene-1-and-17-beta-hydroxysteroid-dehydrogenase-type-1-gene-in-sporadic-breast-cancer-patients
#20
Marwa M Hosny, Nagwan A Sabek, Taghrid B El-Abaseri, Fathalla M Hassan, Sherif H Farrag
Epigenetic modifications are involved in breast carcinogenesis. Identifying genes that are epigenetically silenced via methylation could select target patients for diagnostic as well as therapeutic potential. We assessed promoter methylation of breast cancer susceptibility gene 1 (BRCA1) and 17 Beta Hydroxysteroid Dehydrogenase Type 1 (17βHSD-1) in normal and cancer breast tissues of forty sporadic breast cancer (BC) cases using restriction enzyme based methylation-specific PCR (REMS-PCR). In cancerous tissues, BRCA1 and 17βHSD-1 were methylated in 42...
2016: International Journal of Breast Cancer
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