journal
https://read.qxmd.com/read/24282644/effect-of-socks-on-the-assessment-of-vibration-sensation
#21
R C Meral, Z Matur, B Dertsiz, A E Oge
Objective. To investigate the difference between the measurement of vibration sensation without and with socks. Material and Methods. Fifty healthy volunteers (H group) and 19 patients with diabetic polyneuropathy (PNP group) were included. The sites of measurement were the great toe (GT) and medial malleolus (MM). A standard 128 Hz tuning fork was used in the measurements. Results. Mean duration of vibration sensations without and with socks was as follows: in the H group, 19.4 ± 4.2 and 19.5 ± 4.2 s at GT and 15...
2013: ISRN Neurology
https://read.qxmd.com/read/24260720/production-control-and-visual-guidance-of-saccadic-eye-movements
#22
REVIEW
Jeffrey D Schall
Primate vision is served by rapid shifts of gaze called saccades. This review will survey current knowledge and particular problems concerning the neural control and guidance of gaze shifts.
2013: ISRN Neurology
https://read.qxmd.com/read/24224097/cognitive-dysfunction-and-dementia-in-primary-sj%C3%A3-gren-s-syndrome
#23
JOURNAL ARTICLE
Frederic Blanc, Nadine Longato, Barbara Jung, Catherine Kleitz, Laure Di Bitonto, Benjamin Cretin, Nicolas Collongues, Christelle Sordet, Marie Fleury, Vincent Poindron, Jacques-Eric Gottenberg, Olivier Anne, Dan Lipsker, Thierry Martin, Jean Sibilia, Jérôme de Seze
Background. Primary Sjögren's syndrome (PSS) is a frequent systemic autoimmune disease. In this study, we aimed to explore the cognitive impairment and the correlations with brain MRI. Methods. Twenty-five patients (mean age 55 ± 11.8 years, 21 females) with PSS were prospectively selected and tested with a French translation of the Brief Repeatable Battery for Neuropsychological Examination. The results were compared with the scores for 25 matched patients with multiple sclerosis (MS) and 25 controls. Brain lesions were assessed by brain MRI using the Wahlund classification...
2013: ISRN Neurology
https://read.qxmd.com/read/24205443/body-mass-index-in-multiple-sclerosis-associations-with-csf-neurotransmitter-metabolite-levels
#24
JOURNAL ARTICLE
Manolis Markianos, Maria-Eleftheria Evangelopoulos, Georgios Koutsis, Panagiota Davaki, Constantinos Sfagos
Body weight and height of patients with relapsing-remitting multiple sclerosis (RRMS) or clinically isolated syndrome suggesting MS (CIS) in the age range 18 to 60 years (154 males and 315 females) were compared with those of subjects (146 males and 212 females) free of any major neurological disease. In drug-free patients, CSF levels of the metabolites of noradrenaline (MHPG), serotonin (5-HIAA), and dopamine (HVA), neurotransmitters involved in eating behavior, were estimated in searching for associations with body mass index (BMI)...
2013: ISRN Neurology
https://read.qxmd.com/read/24205442/study-on-the-dynamic-changes-in-synaptic-vesicle-associated-protein-and-axonal-transport-protein-combined-with-lps-neuroinflammation-model
#25
JOURNAL ARTICLE
Rui Zhang, Ming Zhao, Hai-Jie Ji, Yu-He Yuan, Nai-Hong Chen
Microglia activation is the major component of inflammation that constitutes the characteristic of neurodegenerative disease. A large amount of researches have demonstrated that inflammation involved in the pathogenesis of PD process activated microglia acting on the neurons through the release of a variety of inflammatory factors. However, the molecular mechanism underlying how it does work on neurons is still unclear. Here, we show that intracerebral injections of LPS induced Parkinson's disease pathology in C57BL/6J mice...
2013: ISRN Neurology
https://read.qxmd.com/read/24187629/alzheimer-s-disease-screening-biomarkers-using-frequency-doubling-technology-visual-field
#26
JOURNAL ARTICLE
Denise A Valenti
This study was to investigate the feasibility of frequency doubling technology (FDT) visual field testing in Alzheimer's disease (AD) in order to identify early biomarkers of AD in patients already diagnosed with AD and compare the findings to participants not having Alzheimer's disease. This biomarker would be useful in a battery of tests for the early identification of those with AD. It was not the intent to correlate the visual system biomarker with severity of disease, but to determine if the biomarker was present in pass or fail screening criteria...
2013: ISRN Neurology
https://read.qxmd.com/read/24187628/intrathecal-administration-of-autologous-cd34-positive-cells-in-patients-with-past-cerebral-infarction-a-safety-study
#27
JOURNAL ARTICLE
Liming Wang, Haijie Ji, Ming Li, Jianjun Zhou, Wen Bai, Zhanqiang Zhong, Na Li, Delin Zhu, Zijia Zhang, Yongjun Liu, Mingyuan Wu
Regenerative strategies in treatment of stroke have great potential. The goal of the current study was to investigate safety of intrathecal administration of autologous CD34 positive cells in treatment of patients with poststroke. A total of eight male patients with a history of stroke were enrolled. The patients were treated subcutaneously with 5  μ g/kg body weight rhG-CSF for 5 consecutive days, and then leukapheresis was performed to concentrate cells for CD34 positive immunoselection. All patients underwent intrathecal administration of CD34 positive cells via lumbar puncture...
2013: ISRN Neurology
https://read.qxmd.com/read/24171122/zonisamide-induces-crystalluria-without-urinary-ph-changes-in-children-and-young-adults
#28
JOURNAL ARTICLE
Tohshin Go
Purpose. Adjunctive zonisamide therapy was demonstrated to be beneficial for multiple-disabled patients with refractory childhood-onset epilepsy. Zonisamide is well tolerated, but urolithiasis and calcium sludge in the bladder were sometimes described in patients treated with antiepileptic drug polytherapy including zonisamide. In previous studies, alkaline urine and crystalluria were shown to be risk factors for urolithiasis. Therefore, the effects of zonisamide addition and withdrawal on the urinary pH and crystalluria were investigated in patients treated with antiepileptic drug polytherapy to clarify the cause of urolithiasis induced by zonisamide...
2013: ISRN Neurology
https://read.qxmd.com/read/24171121/age-predicts-functional-outcome-in-acute-stroke-patients-with-rt-pa-treatment
#29
JOURNAL ARTICLE
Jarin Chindaprasirt, Kittisak Sawanyawisuth, Paiboon Chattakul, Panita Limpawattana, Somsak Tiamkao, Patcharin Aountri, Verajit Chotmongkol
The standard treatment for acute ischemic stroke is thrombolytic therapy. There is limited data on prognostic factors of acute stroke with thrombolytic therapy particularly in Asian population. Acute ischemic stroke patients who were treated with thrombolytic therapy at Srinagarind Hospital between May 2008 and July 2010 were included. Factors associated with Barthel index more than 80 were studied by multiple logistic regression analysis. There were 75 patients included in the study. The mean NIHSS scores before treatment and at 3 months were 9...
2013: ISRN Neurology
https://read.qxmd.com/read/24167741/association-of-intracranial-aneurysms-with-meningiomas-pituitary-adenomas-and-gliomas-review-of-possible-interrelationships
#30
REVIEW
Kevin Spitler, Doniel Drazin, George Hanna, Ashish Patel, Ray Chu
Asymptomatic intracranial abnormalities are increasingly becoming a focus of attention with the utilization of high-resolution imaging. The concurrence of tumor and aneurysm has been described, largely, by case reports and single-surgeon experiences. Recent papers have outlined the ethics of incidental findings and possible treatment algorithms. Incidental finding of an aneurysm occurs most commonly in patients with meningiomas, pituitary adenomas, and gliomas. Such an association may explain the mechanisms of aneurysm formation, growth, and rupture in acromegalic patients; however, insufficient data are available to link aneurysm with either glioma or meningioma...
2013: ISRN Neurology
https://read.qxmd.com/read/24167740/common-carotid-artery-occlusion-a-case-series
#31
JOURNAL ARTICLE
Zoltán Bajkó, Rodica Bălaşa, Anca Moţăţăianu, Smaranda Maier, Octavia Claudia Chebuţ, Szabolcs Szatmári
Subjects and Methods. We analysed 5000 cerebrovascular ultrasound records. A total of 0.4% of the patients had common carotid artery occlusion (CCAO). Results. The mean age was 59.8 ± 14.2 years, and the male/female ratio was 2.33. The most frequent risk factors were hypertension, ischaemic heart disease, dyslipidemia, diabetes mellitus, and smoking. Right-sided and left-sided CCAO occurred in 65% and 30% of the cases, respectively, and bilateral occlusion was detected in one case (5%). Patent bifurcation was observed in 10 cases of CCAO in which the anterograde flow in the ICA was maintained from the external carotid artery with reversed flow...
2013: ISRN Neurology
https://read.qxmd.com/read/24109519/dynamics-of-b-cell-populations-in-csf-and-blood-in-patients-treated-with-a-combination-of-rituximab-and-mitoxantrone
#32
JOURNAL ARTICLE
Evgeniy Evdoshenko, Alexey Maslyanskiy, Sergey Lapin, Leonid Zaslavsky, Ruth Dobson, Areg Totolian, Alexander Skoromets, Amit Bar-Or
Background. Mitoxantrone (MTX) and Rituximab (RTX) are successfully used for treatment of multiple sclerosis (MS) and can be combined to increase efficacy. Objective. We used MTX, RTX, and methylprednisolone in a single combined regiment and observed patients prospectively. Methods. We present results of observational pilot study of combined therapy of RTX and MTX in 28 patients with active MS. Therapeutic protocol consisted of two infusions within 14 days. First infusion was 1000 mg methylprednisolone (MP) IV, 1000 mg RTX IV, and 20 mg MTX IV...
2013: ISRN Neurology
https://read.qxmd.com/read/24109518/early-versus-late-surgical-treatment-for-neurogenic-thoracic-outlet-syndrome
#33
JOURNAL ARTICLE
Jasem Yousef Al-Hashel, Ashraf Ali M A El Shorbgy, Samar Farouk Ahmed, Rawhia R Elshereef
Objectives. To compare the outcome of early surgical intervention versus late surgical treatment in cases of neurogenic thoracic outlet syndrome (NTOS). Design. Prospective study. Settings. Secondary care (Al-Minia University Hospital, Egypt) from 2007 to 2010. Participants. Thirty-five patients of NTOS (25 women and 10 men, aged 20-52 years), were classified into 2 groups. First group (20 patients) was operated within 3 months of the onset and the second group (15 patients) was operated 6 months after physiotherapy...
2013: ISRN Neurology
https://read.qxmd.com/read/24078881/lesion-induced-alterations-in-astrocyte-glutamate-transporter-expression-and-function-in-the-hippocampus
#34
JOURNAL ARTICLE
Alexandra E Schreiner, Eric Berlinger, Julia Langer, Karl W Kafitz, Christine R Rose
Astrocytes express the sodium-dependent glutamate transporters GLAST and GLT-1, which are critical to maintain low extracellular glutamate concentrations. Here, we analyzed changes in their expression and function following a mechanical lesion in the CA1 area of organotypic hippocampal slices. 6-7 days after lesion, a glial scar had formed along the injury site, containing strongly activated astrocytes with increased GFAP and S100 β immunoreactivity, enlarged somata, and reduced capability for uptake of SR101...
2013: ISRN Neurology
https://read.qxmd.com/read/24062956/preserved-imitation-of-known-gestures-in-children-with-high-functioning-autism
#35
JOURNAL ARTICLE
Joana C Carmo, Raffaella I Rumiati, Roma Siugzdaite, Paolo Brambilla
It has been suggested that children with autism are particularly deficient at imitating novel gestures or gestures without goals. In the present study, we asked high-functioning autistic children and age-matched typically developing children to imitate several types of gestures that could be either already known or novel to them. Known gestures either conveyed a communicative meaning (i.e., intransitive) or involved the use of objects (i.e., transitive). We observed a significant interaction between gesture type and group of participants, with children with autism performing known gestures better than novel gestures...
2013: ISRN Neurology
https://read.qxmd.com/read/23997965/increased-occurrence-of-valproic-acid-induced-hyperammonemia-in-carriers-of-t1405n-polymorphism-in-carbamoyl-phosphate-synthetase-1-gene
#36
JOURNAL ARTICLE
Piotr K Janicki, Dmitri Bezinover, Marek Postula, Robert S Thompson, Jayant Acharya, Vinita Acharya, Cathy McNew, J Daniel Bowman, Iwona Kurkowska-Jastrzebska, Dagmara Mirowska-Guzel
Numerous cases of severe and life-threatening hyperammonemia (HA) related to the treatment of epileptic seizures with valproic acid (VPA) have been previously reported in the medical literature. The aim of this prospective, multicenter study was to verify the putative association between T1405 polymorphism and occurrence of VPA-induced HA in the cohort of 142 adult Caucasian patients with epilepsy treated with VPA for at least 1 year and with normal liver functions. The nonsynonymous T1405N polymorphism genotyping was performed by real-time TaqMan PCR genotyping...
2013: ISRN Neurology
https://read.qxmd.com/read/23984094/vitamin-e-induced-changes-in-glutamate-and-gaba-metabolizing-enzymes-of-chick-embryo-cerebrum
#37
JOURNAL ARTICLE
Ivy Pereira, Shanti N Dessai, Annaliza Pinto
Vitamin E exists in eight different forms, four tocopherols and four tocotrienols. It forms an important component of our antioxidant system. The structure of Vitamin E makes it unique and indispensable in protecting cell membranes. α -tocopherol, one of the forms of Vitamin E, is also known to regulate signal transduction pathways by mechanisms that are independent of its antioxidant properties. Vitamin E compounds reduce the production of inflammatory compounds such as prostaglandins. Swollen, dystrophic axons are considered as the hallmark of Vitamin E deficiency in the brains of rats, monkeys, and humans...
2013: ISRN Neurology
https://read.qxmd.com/read/23984093/the-effect-of-fluoxetine-on-progression-in-progressive-multiple-sclerosis-a-double-blind-randomized-placebo-controlled-trial
#38
JOURNAL ARTICLE
Jop Mostert, Thea Heersema, Manju Mahajan, Jeroen Van Der Grond, Mark A Van Buchem, Jacques De Keyser
Preclinical studies suggest that fluoxetine may have neuroprotective properties. In this pilot study forty-two patients with secondary or primary progressive MS were randomized to receive fluoxetine 20 mg twice daily or placebo for 2 years. Every 3 months the Expanded Disability Status Scale (EDSS), 9-hole peg test (9-HPT) and ambulation index (AI) were assessed. Brain MRI scans, Multiple Sclerosis Functional Composite, Fatigue Impact Scale, Guy's neurological disability Scale and SF-36 were performed at baseline, year 1 and year 2...
2013: ISRN Neurology
https://read.qxmd.com/read/23956876/motor-skill-training-promotes-sensorimotor-recovery-and-increases-microtubule-associated-protein-2-map-2-immunoreactivity-in-the-motor-cortex-after-intracerebral-hemorrhage-in-the-rat
#39
JOURNAL ARTICLE
M V Santos, A S Pagnussat, R G Mestriner, C A Netto
Motor skill learning may induce behavioral and neurophysiological adaptations after intracerebral hemorrhage (ICH). Learning a new motor skill is associated with dendritic reorganization and requires protein synthesis and expression of MAP-2. The purpose of this study was to evaluate motor performance and expression of MAP-2 in the motor cortex of rats submitted to intracerebral hemorrhage model (ICH) and skill task training (SK) or unskilled training (US) during 4 weeks. The Staircase test was used for behavioral evaluation, and relative optical densities and morphometrical analysis were used to estimate MAP-2 immunoreactivity and parameters of brain tissue in both motor cortices...
2013: ISRN Neurology
https://read.qxmd.com/read/23936671/the-role-of-phenytoin-in-the-treatment-of-localization-related-epilepsy-an-international-internet-based-survey-of-neurologists-and-epileptologists
#40
JOURNAL ARTICLE
Rohit R Das, David A Griesemer, Sanjeev V Kothare
Phenytoin (PHT) has been the most widely used medication to treat both partial and generalized seizures. However, over the past twenty years, a variety of new compounds have been released with comparable efficacy, fewer adverse effects, and more predictable pharmacokinetic properties. We surveyed neurologists and epileptologists to determine current practice patterns relating to the use of PHT using an online survey instrument. A total of 200 responses were obtained though response rates for each survey question varied...
2013: ISRN Neurology
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