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Malaria Research and Treatment

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https://www.readbyqxmd.com/read/30002808/modelling-trends-of-climatic-variability-and-malaria-in-ghana-using-vector-autoregression
#1
Sylvia Ankamah, Kaku S Nokoe, Wahab A Iddrisu
Malaria is considered endemic in over hundred countries across the globe. Many cases of malaria and deaths due to malaria occur in Sub-Saharan Africa. The disease is of great public health concern since it affects people of all age groups more especially pregnant women and children because of their vulnerability. This study sought to use vector autoregression (VAR) models to model the impact of climatic variability on malaria. Monthly climatic data (rainfall, maximum temperature, and relative humidity) from 2010 to 2015 were obtained from the Ghana Meteorological Agency while data on malaria for the same period were obtained from the Ghana Health Service...
2018: Malaria Research and Treatment
https://www.readbyqxmd.com/read/29854394/effects-of-drug-policy-changes-on-evolution-of-molecular-markers-of-plasmodium-falciparum-resistance-to-chloroquine-amodiaquine-and-sulphadoxine-pyrimethamine-in-the-south-west-region-of-cameroon
#2
Marcel N Moyeh, Dieudonne L Njimoh, Marie Solange Evehe, Innocent M Ali, Akindeh M Nji, Dominique N Nkafu, Palmer N Masumbe, Atogho-Tiedeu Barbara, Valentine N Ndikum, Wilfred F Mbacham
Background: As a result of the spread of parasites resistant to antimalarial drugs, Malaria treatment guidelines in Cameroon evolved from nonartemisinin monotherapy to artemisinin-based combination therapy. The aim of this study was to assess the effect of these therapy changes on the prevalence of molecular markers of resistance from 2003 to 2013 in Mutengene, Cameroon. Methodology: Dry blood samples (collected in 2003-2005 and 2009-2013) were used for parasite DNA extraction...
2018: Malaria Research and Treatment
https://www.readbyqxmd.com/read/29535856/cross-study-of-malaria-prevalence-in-history-bed-net-utilization-and-knowledge-about-the-disease-among-tanzanian-college-students
#3
Yakobo Nyahoga, Zanda Bochkaeva
University campuses are potential reservoirs of infectious diseases, but they are not in the research focus. It is obvious that the use of malaria preventive tools is extremely necessary in campus conditions in endemic countries. This study is the first malaria survey, conducted in a student campus in Tanzania. This cross-sectional study uncovered a surprisingly high prevalence of malaria history among students: 89,4% of 246 random respondents assume that they had malaria in history, among whom 145 (58,9%) suffered from the disease during the last year...
2018: Malaria Research and Treatment
https://www.readbyqxmd.com/read/29362685/sustained-effectiveness-of-a-fixed-dose-combination-of-artesunate-and-amodiaquine-in-480-patients-with-uncomplicated-plasmodium-falciparum-malaria-in-c%C3%A3-te-d-ivoire
#4
Serge Brice Assi, Abouo Franklin Nguessan, Yapo Thomas Aba, André Offianan Toure, Hervé Menan, Jean Claude Yavo, Koffi Moïse San, Emmanuel Bissagnéné, Stephan Duparc, Valérie Lameyre, Mea Antoine Tanoh
The objective of this study was to monitor the effectiveness of artesunate-amodiaquine fixed-dose combination tablets (ASAQ Winthrop®) in the treatment of uncomplicated Plasmodium falciparum malaria in Côte d'Ivoire. Two enrolment periods (November 2009 to May 2010 and March to October 2013) were compared using an identical design. Subjects with proven monospecific P. falciparum infection according to the WHO diagnostic criteria were eligible. 290 patients during each period received a dose of ASAQ Winthrop tablets appropriate for their age...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/29234551/use-of-insecticide-treated-mosquito-net-among-pregnant-women-and-guardians-of-children-under-five-in-the-democratic-republic-of-the-congo
#5
Joseph N Inungu, Nestor Ankiba, Mark Minelli, Vincent Mumford, Dido Bolekela, Bienvenu Mukoso, Willy Onema, Etienne Kouton, Dolapo Raji
Background: Insecticide-treated mosquito nets (ITNs) are one of the most effective tools for preventing malaria in sub-Saharan Africa. Objective: This study examined knowledge, attitude, and practice on the use of ITNs in the prevention of malaria among pregnant women and guardians of children under five in the Democratic Republic of the Congo. Methods: A total of 5,138 pregnant women and guardians of children under five were interviewed. Results: The majority of participants (>80%) knew the signs and symptoms of malaria; 81...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/29057138/detection-of-plasmodium-aldolase-using-a-smartphone-and-microfluidic-enzyme-linked-immunosorbent-assay
#6
Nikhil S Gopal, Ruben Raychaudhuri
BACKGROUND: Malaria control efforts are limited in rural areas. A low-cost system to monitor response without the use of electricity is needed. Plasmodium aldolase is a malaria biomarker measured using enzyme linked immunosorbent assay (ELISA) techniques. A three-part system using ELISA was developed consisting of a microfluidic chip, hand crank centrifuge, and a smartphone. METHODS: A circular microfluidic chip was fabricated using clear acrylic and a CO2 laser...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28932617/visceral-leishmaniasis-malaria-coinfection-and-their-associated-factors-in-patients-attending-metema-hospital-northwest-ethiopia-suggestion-for-integrated-vector-management
#7
Getachew Ferede, Ermias Diro, Sisay Getie, Gebeyaw Getnet, Yegnasew Takele, Anteneh Amsalu, Yitayih Wondimeneh
BACKGROUND: Despite high prevalence of visceral leishmaniasis and malaria in the study area, their coinfection remains unknown. Therefore, this study was aimed to document VL-malaria coinfections and their associated factors. METHODS: A cross-sectional study was conducted among clinical suspected VL patients attending Metema hospital, Northwest Ethiopia, from January 2014 to June 2014. Blood sample was tested by rk39 antigen-based DiaMed IT-Leish dipstick and Giemsa stain microscopic examination of thick and thin blood smears for malaria detection was performed...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28856028/bibliometric-analysis-of-worldwide-publications-on-antimalarial-drug-resistance-2006-2015
#8
REVIEW
Waleed M Sweileh, Samah W Al-Jabi, Ansam F Sawalha, Adham S AbuTaha, Sa'ed H Zyoud
BACKGROUND: In response to international efforts to control and eradicate malaria, we designed this study to give a bibliometric overview of research productivity in antimalarial drug resistance (AMDR). METHODS: Keywords related to AMDR were used to retrieve relevant literature using Scopus database. RESULTS: A total of 976 publications with an h-index of 63 were retrieved. The number of publications showed a noticeable increase starting in the early 1990s...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28828192/low-utilization-of-insecticide-treated-bed-net-among-pregnant-women-in-the-middle-belt-of-ghana
#9
Grace Manu, Ellen Abrafi Boamah-Kaali, Lawrence Gyabaa Febir, Emmanuel Ayipah, Seth Owusu-Agyei, Kwaku Poku Asante
BACKGROUND: Malaria in pregnancy leads to low birth weight, premature birth, anaemia, and maternal and neonatal mortality. Use of insecticide-treated nets (ITNs) during pregnancy is one of the proven interventions to reduce the malaria burden. However, Ghana has not achieved its target for ITN use among pregnant women. METHODS: A qualitative study was conducted in seven communities purposively selected from the middle belt of Ghana. Participants who had delivered in the six months prior to this study were selected...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28607799/major-polymorphisms-of-genes-involved-in-homocysteine-metabolism-in-malaria-patients-in-ouagadougou-burkina-faso
#10
Noé Yameogo, Bapio Valérie Elvira Jean Télesphore Bazie, Abdoul Karim Ouattara, Pouiré Yameogo, Tegwinde Rebeca Compaore, Dorcas Obiri-Yeboah, Florencia Wenkuuni Djigma, Simplice Damintoti Karou, Jacques Simpore
This study analyzed the four main polymorphisms of the genes in homocysteine metabolism in malaria patients. Forty-two randomly selected subjects, diagnosed positive for Plasmodium falciparum, were included. The four genotypes were detected by real-time PCR using the MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, and MTRR 66A>G detection kit (Sacace Biotechnologies REF: T01002-96-S). The results revealed frequencies of 90% 677CC, 10% 677CT, and 00% 677TT for MTHFR C677T; 78.6% 1298AA, 19% 1298AC, and 2...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28491482/long-term-prophylaxis-and-pharmacokinetic-evaluation-of-intramuscular-nano-and-microparticle-decoquinate-in-mice-infected-with-p-berghei-sporozoites
#11
Qigui Li, Lisa Xie, Diana Caridha, Qiang Zeng, Jing Zhang, Norma Roncal, Ping Zhang, Chau Vuong, Brittney Potter, Jason Sousa, Sean Marcsisin, Lisa Read, Mark Hickman
Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were conducted at various single intramuscular-decoquinate doses for 2, 4, 6, or 8 weeks prior to infection with P. berghei sporozoites. The liver stage efficacy evaluation was monitored by using an in vivo imaging system. Full causal prophylaxis was shown in mice with a single intramuscular dose at 120 mg/kg of nanoparticle decoquinate (0...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28465859/monitoring-compliance-and-acceptability-of-intermittent-preventive-treatment-of-malaria-using-sulfadoxine-pyrimethamine-after-ten-years-of-implementation-in-tanzania
#12
Mdetele B Ayubu, Winifrida B Kidima
Intermittent preventive treatment using SP (IPTp-SP) is still a superior interventional approach to control malaria during pregnancy. However its rate of use has gone down tremendously in malaria endemic areas. This study forms part of a larger study aimed at monitoring the compliance of IPTp-SP policy in malaria endemic areas of Tanzania. Two cross-sectional studies were conducted in Dar es Salaam and Njombe Regions of Tanzania. Overall, 540 pregnant women and 21 healthcare workers were interviewed using structured questionnaires...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28367352/statistical-methods-for-predicting-malaria-incidences-using-data-from-sudan
#13
Hamid H Hussien, Fathy H Eissa, Khidir E Awadalla
Malaria is the leading cause of illness and death in Sudan. The entire population is at risk of malaria epidemics with a very high burden on government and population. The usefulness of forecasting methods in predicting the number of future incidences is needed to motivate the development of a system that can predict future incidences. The objective of this paper is to develop applicable and understood time series models and to find out what method can provide better performance to predict future incidences level...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28255497/a-weather-based-prediction-model-of-malaria-prevalence-in-amenfi-west-district-ghana
#14
Esther Love Darkoh, John Aseidu Larbi, Eric Adjei Lawer
This study investigated the effects of climatic variables, particularly, rainfall and temperature, on malaria incidence using time series analysis. Our preliminary analysis revealed that malaria incidence in the study area decreased at about 0.35% annually. Also, the month of November recorded approximately 21% more malaria cases than the other months while September had a decreased effect of about 14%. The forecast model developed for this investigation indicated that mean minimum (P = 0.01928) and maximum (P = 0...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28074170/nonobese-diabetic-nod-mice-lack-a-protective-b-cell-response-against-the-nonlethal-plasmodium-yoelii-17xnl-malaria-protozoan
#15
Mirian Mendoza, Luis Pow Sang, Qi Qiu, Sofia Casares, Teodor-D Brumeanu
Background. Plasmodium yoelii 17XNL is a nonlethal malaria strain in mice of different genetic backgrounds including the C57BL/6 mice (I-A(b)/I-E(null)) used in this study as a control strain. We have compared the trends of blood stage infection with the nonlethal murine strain of P. yoelii 17XNL malaria protozoan in immunocompetent Nonobese Diabetic (NOD) mice prone to type 1 diabetes (T1D) and C57BL/6 mice (control mice) that are not prone to T1D and self-cure the P. yoelii 17XNL infection. Prediabetic NOD mice could not mount a protective antibody response to the P...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28070444/burden-of-placental-malaria-among-pregnant-women-who-use-or-do-not-use-intermittent-preventive-treatment-at-mulago-hospital-kampala
#16
Charles Okot Odongo, Michael Odida, Henry Wabinga, Celestino Obua, Josaphat Byamugisha
Intermittent preventive treatment of malaria in pregnancy with sulphadoxine-pyrimethamine (SP-IPTp) is widely used to reduce the incidence of adverse pregnancy outcomes. As a monitor for continued effectiveness of this intervention amidst SP resistance, we aimed to assess malaria burden among pregnant women who use or do not use SP-IPTp. In a descriptive cohort study at Mulago Hospital, Kampala, 87 women who received two supervised doses of SP-IPTp were followed up until delivery. Controls were pregnant women presenting in early labour without history of SP-IPTp...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28050307/inhibition-of-in-vivo-growth-of-plasmodium-berghei-by-launaea-taraxacifolia-and-amaranthus-viridis-in-mice
#17
Adewale Adetutu, Olubukola S Olorunnisola, Abiodun O Owoade, Peter Adegbola
Launaea taraxacifolia and Amaranthus viridis used by people of Western Africa in the treatment of malaria and related symptoms were assessed for their antiplasmodial value against the chloroquine sensitive strain of Plasmodium berghei. Crude extracts (200 mg/kg) and chloroquine (5 mg/kg) were administered to different groups of Swiss mice. The percentage of parasitemia, survival time, and haematological parameters were determined. Both extracts significantly (p < 0.05) inhibited parasitemia and improved survival time in infected mice...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27840766/maternal-attitudes-about-objectively-monitored-bednet-use-in-rural-uganda
#18
Paul J Krezanoski, Data Santorino, Nuriat Nambogo, Jeffrey I Campbell, David R Bangsberg
Insecticide-treated bednets (ITNs) are a mainstay of malaria prevention, yet poor adherence poses a major barrier to effective prevention. Self-reports of bednet use suffer from recall and social desirability biases. We have designed a device that electronically records ITN usage longitudinally. SmartNet consists of circuits made from a conductive fabric interwoven into the sides and top of a rectangular ITN. Digital sampling of the state of these circuits allows for determining whether the SmartNet is deployed for use or folded up...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27493827/cost-effectiveness-and-validity-assessment-of-cyscope-microscope-quantitative-buffy-coat-microscope-and-rapid-diagnostic-kit-for-malaria-diagnosis-among-clinic-attendees-in-ibadan-nigeria
#19
Abiodun Ogunniyi, Magbagbeola David Dairo, Hannah Dada-Adegbola, Ikeoluwapo O Ajayi, Adebola Olayinka, Wellington A Oyibo, Olufunmilayo I Fawole, Olufemi Ajumobi
Background. Unavailability of accurate, rapid, reliable, and cost-effective malaria diagnostic instruments constitutes major a challenge to malaria elimination. We validated alternative malaria diagnostic instruments and assessed their comparative cost-effectiveness. Method. Using a cross-sectional study design, 502 patients with malaria symptoms at selected health facilities in Ibadan between January and April 2014 were recruited consecutively. We examined malaria parasites using Cyscope®, QBC, and CareStart™ and results were compared to light microscopy (LM)...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27403371/the-effect-of-long-lasting-insecticide-bed-net-use-on-malaria-prevalence-in-the-tombel-health-district-south-west-region-cameroon
#20
Eric B Fokam, Kevin T J Dzi, Leonard Ngimuh, Peter Enyong
Malaria remains a major public health problem in Africa, and its prevalence in Cameroon stands at 29%. Long Lasting Insecticide Nets (LLINs) were distributed in 2011 to reduce malaria mortality and morbidity; however, assessment of this intervention is scanty. The present study in the Tombel health district (THD) investigated the impact of this distribution on malaria prevalence. A total of 31,657 hospital records from 3 health facilities in 3 health areas for 2010-2013 were examined. Records for 2010 and 2011 provided predistribution baseline data, while those of 2012 and 2013 represented postdistribution data...
2016: Malaria Research and Treatment
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