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Malaria Research and Treatment

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https://www.readbyqxmd.com/read/28607799/major-polymorphisms-of-genes-involved-in-homocysteine-metabolism-in-malaria-patients-in-ouagadougou-burkina-faso
#1
Noé Yameogo, Bapio Valérie Elvira Jean Télesphore Bazie, Abdoul Karim Ouattara, Pouiré Yameogo, Tegwinde Rebeca Compaore, Dorcas Obiri-Yeboah, Florencia Wenkuuni Djigma, Simplice Damintoti Karou, Jacques Simpore
This study analyzed the four main polymorphisms of the genes in homocysteine metabolism in malaria patients. Forty-two randomly selected subjects, diagnosed positive for Plasmodium falciparum, were included. The four genotypes were detected by real-time PCR using the MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, and MTRR 66A>G detection kit (Sacace Biotechnologies REF: T01002-96-S). The results revealed frequencies of 90% 677CC, 10% 677CT, and 00% 677TT for MTHFR C677T; 78.6% 1298AA, 19% 1298AC, and 2...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28491482/long-term-prophylaxis-and-pharmacokinetic-evaluation-of-intramuscular-nano-and-microparticle-decoquinate-in-mice-infected-with-p-berghei-sporozoites
#2
Qigui Li, Lisa Xie, Diana Caridha, Qiang Zeng, Jing Zhang, Norma Roncal, Ping Zhang, Chau Vuong, Brittney Potter, Jason Sousa, Sean Marcsisin, Lisa Read, Mark Hickman
Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were conducted at various single intramuscular-decoquinate doses for 2, 4, 6, or 8 weeks prior to infection with P. berghei sporozoites. The liver stage efficacy evaluation was monitored by using an in vivo imaging system. Full causal prophylaxis was shown in mice with a single intramuscular dose at 120 mg/kg of nanoparticle decoquinate (0...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28465859/monitoring-compliance-and-acceptability-of-intermittent-preventive-treatment-of-malaria-using-sulfadoxine-pyrimethamine-after-ten-years-of-implementation-in-tanzania
#3
Mdetele B Ayubu, Winifrida B Kidima
Intermittent preventive treatment using SP (IPTp-SP) is still a superior interventional approach to control malaria during pregnancy. However its rate of use has gone down tremendously in malaria endemic areas. This study forms part of a larger study aimed at monitoring the compliance of IPTp-SP policy in malaria endemic areas of Tanzania. Two cross-sectional studies were conducted in Dar es Salaam and Njombe Regions of Tanzania. Overall, 540 pregnant women and 21 healthcare workers were interviewed using structured questionnaires...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28367352/statistical-methods-for-predicting-malaria-incidences-using-data-from-sudan
#4
Hamid H Hussien, Fathy H Eissa, Khidir E Awadalla
Malaria is the leading cause of illness and death in Sudan. The entire population is at risk of malaria epidemics with a very high burden on government and population. The usefulness of forecasting methods in predicting the number of future incidences is needed to motivate the development of a system that can predict future incidences. The objective of this paper is to develop applicable and understood time series models and to find out what method can provide better performance to predict future incidences level...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28255497/a-weather-based-prediction-model-of-malaria-prevalence-in-amenfi-west-district-ghana
#5
Esther Love Darkoh, John Aseidu Larbi, Eric Adjei Lawer
This study investigated the effects of climatic variables, particularly, rainfall and temperature, on malaria incidence using time series analysis. Our preliminary analysis revealed that malaria incidence in the study area decreased at about 0.35% annually. Also, the month of November recorded approximately 21% more malaria cases than the other months while September had a decreased effect of about 14%. The forecast model developed for this investigation indicated that mean minimum (P = 0.01928) and maximum (P = 0...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28074170/nonobese-diabetic-nod-mice-lack-a-protective-b-cell-response-against-the-nonlethal-plasmodium-yoelii-17xnl-malaria-protozoan
#6
Mirian Mendoza, Luis Pow Sang, Qi Qiu, Sofia Casares, Teodor-D Brumeanu
Background. Plasmodium yoelii 17XNL is a nonlethal malaria strain in mice of different genetic backgrounds including the C57BL/6 mice (I-A(b)/I-E(null)) used in this study as a control strain. We have compared the trends of blood stage infection with the nonlethal murine strain of P. yoelii 17XNL malaria protozoan in immunocompetent Nonobese Diabetic (NOD) mice prone to type 1 diabetes (T1D) and C57BL/6 mice (control mice) that are not prone to T1D and self-cure the P. yoelii 17XNL infection. Prediabetic NOD mice could not mount a protective antibody response to the P...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28070444/burden-of-placental-malaria-among-pregnant-women-who-use-or-do-not-use-intermittent-preventive-treatment-at-mulago-hospital-kampala
#7
Charles Okot Odongo, Michael Odida, Henry Wabinga, Celestino Obua, Josaphat Byamugisha
Intermittent preventive treatment of malaria in pregnancy with sulphadoxine-pyrimethamine (SP-IPTp) is widely used to reduce the incidence of adverse pregnancy outcomes. As a monitor for continued effectiveness of this intervention amidst SP resistance, we aimed to assess malaria burden among pregnant women who use or do not use SP-IPTp. In a descriptive cohort study at Mulago Hospital, Kampala, 87 women who received two supervised doses of SP-IPTp were followed up until delivery. Controls were pregnant women presenting in early labour without history of SP-IPTp...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28050307/inhibition-of-in-vivo-growth-of-plasmodium-berghei-by-launaea-taraxacifolia-and-amaranthus-viridis-in-mice
#8
Adewale Adetutu, Olubukola S Olorunnisola, Abiodun O Owoade, Peter Adegbola
Launaea taraxacifolia and Amaranthus viridis used by people of Western Africa in the treatment of malaria and related symptoms were assessed for their antiplasmodial value against the chloroquine sensitive strain of Plasmodium berghei. Crude extracts (200 mg/kg) and chloroquine (5 mg/kg) were administered to different groups of Swiss mice. The percentage of parasitemia, survival time, and haematological parameters were determined. Both extracts significantly (p < 0.05) inhibited parasitemia and improved survival time in infected mice...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27840766/maternal-attitudes-about-objectively-monitored-bednet-use-in-rural-uganda
#9
Paul J Krezanoski, Data Santorino, Nuriat Nambogo, Jeffrey I Campbell, David R Bangsberg
Insecticide-treated bednets (ITNs) are a mainstay of malaria prevention, yet poor adherence poses a major barrier to effective prevention. Self-reports of bednet use suffer from recall and social desirability biases. We have designed a device that electronically records ITN usage longitudinally. SmartNet consists of circuits made from a conductive fabric interwoven into the sides and top of a rectangular ITN. Digital sampling of the state of these circuits allows for determining whether the SmartNet is deployed for use or folded up...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27493827/cost-effectiveness-and-validity-assessment-of-cyscope-microscope-quantitative-buffy-coat-microscope-and-rapid-diagnostic-kit-for-malaria-diagnosis-among-clinic-attendees-in-ibadan-nigeria
#10
Abiodun Ogunniyi, Magbagbeola David Dairo, Hannah Dada-Adegbola, Ikeoluwapo O Ajayi, Adebola Olayinka, Wellington A Oyibo, Olufunmilayo I Fawole, Olufemi Ajumobi
Background. Unavailability of accurate, rapid, reliable, and cost-effective malaria diagnostic instruments constitutes major a challenge to malaria elimination. We validated alternative malaria diagnostic instruments and assessed their comparative cost-effectiveness. Method. Using a cross-sectional study design, 502 patients with malaria symptoms at selected health facilities in Ibadan between January and April 2014 were recruited consecutively. We examined malaria parasites using Cyscope®, QBC, and CareStart™ and results were compared to light microscopy (LM)...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27403371/the-effect-of-long-lasting-insecticide-bed-net-use-on-malaria-prevalence-in-the-tombel-health-district-south-west-region-cameroon
#11
Eric B Fokam, Kevin T J Dzi, Leonard Ngimuh, Peter Enyong
Malaria remains a major public health problem in Africa, and its prevalence in Cameroon stands at 29%. Long Lasting Insecticide Nets (LLINs) were distributed in 2011 to reduce malaria mortality and morbidity; however, assessment of this intervention is scanty. The present study in the Tombel health district (THD) investigated the impact of this distribution on malaria prevalence. A total of 31,657 hospital records from 3 health facilities in 3 health areas for 2010-2013 were examined. Records for 2010 and 2011 provided predistribution baseline data, while those of 2012 and 2013 represented postdistribution data...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27190671/increased-prevalence-of-mutant-allele-pfdhps-437g-and-pfdhfr-triple-mutation-in-plasmodium-falciparum-isolates-from-a-rural-area-of-gabon-three-years-after-the-change-of-malaria-treatment-policy
#12
Jacques-Mari Ndong Ngomo, Denise Patricia Mawili-Mboumba, Noé Patrick M'Bondoukwe, Rosalie Nikiéma Ndong Ella, Marielle Karine Bouyou Akotet
In Gabon, sulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive treatment during pregnancy (IPTp-SP) and for uncomplicated malaria treatment through ACTs drug. P. falciparum strains resistant to SP are frequent in areas where this drug is highly used and is associated with the occurrence of mutations on Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) genes. The aim of the study was to compare the proportion of mutations on Pfdhfr and Pfdhps genes in isolates collected at Oyem in northern Gabon, in 2005 at the time of IPTp-SP introduction and three years later...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27066290/assessing-the-role-of-climate-change-in-malaria-transmission-in-africa
#13
E T Ngarakana-Gwasira, C P Bhunu, M Masocha, E Mashonjowa
The sensitivity of vector borne diseases like malaria to climate continues to raise considerable concern over the implications of climate change on future disease dynamics. The problem of malaria vectors shifting from their traditional locations to invade new zones is of important concern. A mathematical model incorporating rainfall and temperature is constructed to study the transmission dynamics of malaria. The reproduction number obtained is applied to gridded temperature and rainfall datasets for baseline climate and future climate with aid of GIS...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27047701/severe-malaria-associated-with-plasmodium-falciparum-and-p-vivax-among-children-in-pawe-hospital-northwest-ethiopia
#14
Getachew Geleta, Tsige Ketema
Despite rigorous effort made to control malaria for more than a century, it is still among the main public health problems in least developed regions of the world. Majority of deaths associated with malaria occur in sub-Sahara Africa among biologically risked groups. Thus, this study was designed to assess the incidence of severe malaria syndromes among children in Pawe Hospital, Northwest Ethiopia. Children seeking medication for malaria infection in Pawe Hospital during the study period were recruited. Sociodemographic characteristics, physical, hematological, and clinical features of complicated malaria were assessed following standard parasitological and clinical procedures...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/27042376/improving-access-to-malaria-rapid-diagnostic-test-in-niger-state-nigeria-an-assessment-of-implementation-up-to-2013
#15
REVIEW
Olatunji Joshua Awoleye, Chris Thron
Nigeria's 2009-2013 malaria strategic plan adopted WHO diagnosis and treatment guidelines, which include the use of rapid diagnostic tests (RDTs) prior to prescribing treatment with artemisinin combination therapies (ACTs). The current study explores accessibility barriers to the use of RDTs in Niger State and makes recommendations for improving the uptake of RDTs. The study employs literature review, review of data from the Niger State Health Management Information System for January-October 2013, and application of Peters' conceptual framework for assessing access to health services...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/26942036/high-prevalence-of-plasmodium-falciparum-infection-in-asymptomatic-individuals-from-the-democratic-republic-of-the-congo
#16
Dieudonné Makaba Mvumbi, Thierry Lengu Bobanga, Pierrette Melin, Patrick De Mol, Jean-Marie Ntumba Kayembe, Hippolyte Nani-Tuma Situakibanza, Georges Lelo Mvumbi, Célestin Ndosimao Nsibu, Solange Efundu Umesumbu, Marie-Pierre Hayette
Malaria remains a major public health problem in the Democratic Republic of Congo (DRC) with 14 million cases reported by the WHO Malaria Report in 2014. Asymptomatic malaria cases are known to be prevalent in endemic areas and are generally untreated, resulting in a significant source of gametocytes that may serve as reservoir of disease transmission. Considering that microscopy certainly underestimates the prevalence of Plasmodium infections within asymptomatic carriers and that PCR assays are currently recognized as the most sensitive methods for Plasmodium identification, this study was conducted to weigh the asymptomatic carriage in DRC by a molecular method...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/26925291/assessing-abo-rh-blood-group-frequency-and-association-with-asymptomatic-malaria-among-blood-donors-attending-arba-minch-blood-bank-south-ethiopia
#17
Getaneh Alemu, Mohammedaman Mama
Background. Determination of the various ABO/Rh blood group distributions and their association with malaria infection has paramount importance in the context of transfusion medicine and malaria control. Methods. Facility based cross-sectional study was conducted from February to June, 2015, to assess ABO/Rh blood groups distribution and their association with asymptomatic malaria. A structured questionnaire was used to collect data. Blood grouping was done using monoclonal antibodies. Thin and thick blood films were examined for Plasmodium parasites...
2016: Malaria Research and Treatment
https://www.readbyqxmd.com/read/26839732/acceptance-and-utilisation-of-sulphadoxine-pyrimethamine-and-insecticide-treated-nets-among-pregnant-women-in-oyo-state-nigeria
#18
Aderonke A Adeola, Eugenia A Okwilagwe
The study is an investigation of the acceptance and utilisation of Sulphadoxine-Pyrimethamine (Fansidar), the drug of choice for Intermittent Preventive Treatment in pregnancy, and Insecticide-Treated Nets among pregnant women who access different health facilities in Oyo State, Nigeria. Pregnant women (582) attending government primary healthcare antenatal clinics and 50 attending faith clinics purposively selected responded to structured instruments that were analysed using percentages, t-test correlation, and multiple regression...
2015: Malaria Research and Treatment
https://www.readbyqxmd.com/read/26770866/trend-analysis-of-malaria-occurrence-in-wolaita-zone-southern-ethiopia-retrospective-cross-sectional-study
#19
Deresse Legesse, Yusuf Haji, Solomon Abreha
Background. Malaria is a major public health problem in Ethiopia. The trend of malaria occurrence remains unknown in the study area. This study is aimed at determining the last five years' trend of malaria occurrence from 2008/09 to 2012/13 in Wolaita Zone, Southern Ethiopia. Methods. A health facility-based retrospective study was conducted in Wolaita Zone from March to August, 2014. Five years' laboratory confirmed malaria record review was made from six health centers. Result. A total of 105,755 laboratory confirmed malaria cases were reported, with total slide positivity rate of 33...
2015: Malaria Research and Treatment
https://www.readbyqxmd.com/read/26693382/analysis-of-trend-of-malaria-prevalence-in-the-ten-asian-countries-from-2006-to-2011-a-longitudinal-study
#20
REVIEW
Shongkour Roy, Tanjina Khatun
Background. To control the malaria mortality, the global and national communities have worked together and produced impressive results in the world. Some of the Asian counties' malaria mortality rate is more compared to countries with high health facilities around the world. This paper's main aim is to describe trend of malaria cases and mortality in 10 Asian countries using the World Health Organization data. Methods. Malaria mortality data was collected systematically from WHO and UN database for the period 2006-2011...
2015: Malaria Research and Treatment
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