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Journal of Parkinson's Disease

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https://www.readbyqxmd.com/read/30412506/qualitative-evaluation-of-the-personal-kinetigraphtm-movement-recording-system-in-a-parkinson-s-clinic
#1
Anthony Santiago, James W Langston, Rita Gandhy, Rohit Dhall, Salima Brillman, Linda Rees, Carolee Barlow
BACKGROUND: Wearable-sensors provide accurate, continuous objective measurements, quantifying the variable motor states of patients with Parkinson's disease (PD) in real time. OBJECTIVES: To evaluate the impact of using continuous objective measurement using the Personal KinetiGraph™ (PKG™) Movement Recording System in the routine clinical care of patients with PD (PwP). METHODS: Physicians employed the use of the PKG in patients for whom they were seeking objective measurement...
November 8, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30400106/conversion-of-l-dopa-to-extended-release-l-dopa-rytary%C3%A2-in-patients-with-fluctuating-parkinson-s-disease-predictor-s-of-dose
#2
William Ondo, Pablo Coss, Melissa Christie, Belen Pascual
BACKGROUND: A new extended release levodopa capsule (C/L ERC), Rytary®, has demonstrated improved "on" time in fluctuating Parkinson's disease patients, compared to optimally dosed immediate release levodopa. The milligram dosing, however, differs markedly and no empiric ratio or formula for dose conversion currently exists. OBJECTIVE: To determine the most effective conversion strategy from C/L to C/L ERC. METHODS: We reviewed fluctuating PD patients with problematic "off" time who were converted to C/L ERC using a semi-structured dose titration schedule, and collected data regarding basic efficacy, tolerability, and dosing, in order to determine an empirically based dose conversion formula...
October 31, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30400105/interpreting-genetic-variants-hints-from-a-family-cluster-of-parkinson-s-disease
#3
Francesco Cali, Mariagiovanna Cantone, Filomena Irene Ilaria Cosentino, Giuseppe Lanza, Giuseppa Ruggeri, Valeria Chiavetta, Roberto Salluzzo, Alda Ragalmuto, Mirella Vinci, Raffaele Ferri
Technological innovation related to the advent and development of the Next-Generation Sequencing (NGS) has provided significant advances in the diagnosis of disorders with genetic and phenotypic variability, such as neurodegenerative diseases. However, the interpretation of NGS data often remains challenging, although advanced prediction tools have contributed to primarily assess the impact of some missense variants. Here, we report a patient with Parkinson's disease (PD) and a family history of disease, in which a panel of 29 disease-causing or risk genes for PD were analyzed...
October 30, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30400107/a-proposed-roadmap-for-parkinson-s-disease-proof-of-concept-clinical-trials-investigating-compounds-targeting-alpha-synuclein
#4
Kalpana M Merchant, Jesse M Cedarbaum, Patrik Brundin, Kuldip D Dave, Jamie Eberling, Alberto J Espay, Samantha J Hutten, Monica Javidnia, Johan Luthman, Walter Maetzler, Liliana Menalled, Alyssa N Reimer, A Jon Stoessl, David M Weiner
The convergence of human molecular genetics and Lewy pathology of Parkinson's disease (PD) have led to a robust, clinical-stage pipeline of alpha-synuclein (α-syn)-targeted therapies that have the potential to slow or stop the progression of PD and other synucleinopathies. To facilitate the development of these and earlier stage investigational molecules, the Michael J. Fox Foundation for Parkinson's Research convened a group of leaders in the field of PD research from academia and industry, the Alpha-Synuclein Clinical Path Working Group...
October 29, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30373961/haplotype-analysis-on-the-relationship-of-the-dnajc6-gene-with-early-onset-parkinson-s-disease-risk-in-a-chinese-population
#5
Ting Shen, Shuai Zhao, Yasi Jiang, Jiali Pu, Hsin-Yi Lai, Yaping Yan, Jun Tian, Yanxin Chen, Baorong Zhang
BACKGROUND: DNAJC6 gene is one of the Parkinson's disease (PD) related genes, but relationship between DNAJC6 polymorphisms and PD remains unclear. OBJECTIVE: We aims to examine the association between genetic variations in DNAJC6 gene and idiopathic early-onset PD (EOPD) in the Chinese population. METHODS: Exons and intron/exon boundaries of DNAJC6 gene was amplified and sequenced in 135 EOPD patients and 212 healthy controls. Single nucleotide polymorphisms (SNP)-based and haplotype-based association study between EOPD and DNAJC6 was conducted...
October 26, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30373962/the-voice-of-the-parkinson-customer
#6
Floris P Vlaanderen, Lonneke Rompen, Marten Munneke, Marije Stoffer, Bastiaan R Bloem, Marjan J Faber
BACKGROUND AND OBJECTIVES: To improve the care for patients with chronic neurological conditions like Parkinson's disease, identifying the core needs of patients is crucial. In this article, we present the Voice of the Customer approach (originally developed in the field of industry to probe the clients' needs), a novel methodology to identify these needs. METHODS: A group of 12 discussants carried out in depth interviews to patients (n = 20), relatives (n = 12) and healthcare professionals (n = 11)...
October 23, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29689735/erratum-to-modeling-parkinson-s-disease-in-c-elegans
#7
(no author information available yet)
No abstract text is available yet for this article.
March 26, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30248065/feasibility-and-safety-of-multicenter-tissue-and-biofluid-sampling-for-%C3%AE-synuclein-in-parkinson-s-disease-the-systemic-synuclein-sampling-study-s4
#8
Lana M Chahine, Thomas G Beach, Nicholas Seedorff, Chelsea Caspell-Garcia, Christopher S Coffey, Michael Brumm, Charles H Adler, Geidy E Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, Vanessa Arnedo, Lindsey Riley, K D Dave, Brit Mollenhauer
BACKGROUND: α-synuclein is a lead Parkinson's disease (PD) biomarker. There are conflicting reports regarding accuracy of α-synuclein in different tissues and biofluids as a PD biomarker, and the within-subject anatomical distribution of α-synuclein is not well described. The Systemic Synuclein Sampling Study (S4) aims to address these gaps in knowledge. The S4 is a multicenter, cross-sectional, observational study evaluating α-synuclein in multiple tissues and biofluids in PD and healthy controls (HC)...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30248064/multimorbidity-predicts-quality-of-life-but-not-motor-severity-in-early-parkinson-s-disease
#9
Rhys Gravell, Gordon W Duncan, Tien K Khoo, David J Burn, Avan A Sayer, Roger A Barker, Rachael Ashleigh Lawson, Alison Jane Yarnall
Recent guidance by the National Institute for Health and Care Excellence (NICE) focuses on the management of people with multimorbidity, including Parkinson's disease (PD). To date there has been little exploration of this in neurodegenerative diseases. This study aimed to explore the associations between multimorbidity, motor severity and quality of life (QoL) in early PD. Regression analyses determined whether multimorbidity was significantly associated with disease severity and QoL. Multimorbidity was a small but significant predictor of QoL in people with incident PD, but not motor severity, suggesting that they may benefit from a tailored multidisciplinary approach to care...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30248063/ptprc-expression-in-blood-is-downregulated-in-parkinson-s-and-progressive-supranuclear-palsy-disorders
#10
Virginie Bottero, Jose A Santiago, Judith A Potashkin
BACKGROUND: Parkinson's disease (PD) shares pathological and clinical features with progressive supranuclear palsy (PSP) patients making the diagnosis challenging. Distinguishing PD from PSP is crucial given differences in disease course, treatment and clinical management. OBJECTIVE: Although some progress has been made in the discovery of biomarkers for PD and PSP, there is an urgent need to identify additional biomarkers capable of distinguishing between these diseases...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30248062/investigating-voice-as-a-biomarker-for-leucine-rich-repeat-kinase-2-associated-parkinson-s-disease
#11
Siddharth Arora, Naomi P Visanji, Tiago A Mestre, Athanasios Tsanas, Amaal AlDakheel, Barbara S Connolly, Carmen Gasca-Salas, Drew S Kern, Jennifer Jain, Elizabeth J Slow, Achinoam Faust-Socher, Anthony E Lang, Max A Little, Connie Marras
We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30175983/the-role-of-tmem230-gene-in-parkinson-s-disease
#12
Hao Deng, Kuan Fan, Joseph Jankovic
Parkinson's disease (PD) is a common neurodegenerative disease whose pathogenesis remains unknown. TMEM230 gene, encoding a transmembrane protein in secretory and recycling vesicle, has been recently identified as a novel disease-causing gene of autosomal dominant PD with Lewy pathology and typical clinical symptoms. Although its mutation and variants seem to be rare in PD patients, functional studies have indicated that TMEM230 protein probably plays an important role in secretory and recycling pathway and may be involved in Lewy pathological mechanism...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30149466/objective-arm-swing-analysis-in-early-stage-parkinson-s-disease-using-an-rgb-d-camera-kinect%C3%A2
#13
Beatriz Muñoz Ospina, Jaime Andrés Valderrrama Chaparro, Juan David Arango Paredes, Yor Jaggy Castaño Pino, Andrés Navarro, Jorge Luis Orozco
BACKGROUND: Arm swing changes are common even in the early stages of Parkinson's disease (PD). We hypothesized that arm swing changes decrease with age and can be detected using a low-cost, RGB-D depth-sensing camera. OBJECTIVE: This study aimed to assess the differences in arm swing between PD patients and healthy participants and to investigate the possible effects of aging on these differences. METHODS: Twenty-five PD patients (aged 45-87 years) and 25 age-matched, healthy subjects (aged 46-88 years) were included...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30149465/weight-loss-in-parkinson-s-disease-no-evidence-for-role-of-small-intestinal-bacterial-overgrowth
#14
John K DiBaise, Michael D Crowell, Erika Driver-Dunckley, Shyamal H Mehta, Charlene Hoffman-Snyder, Tanya Lin, Charles H Adler
BACKGROUND AND OBJECTIVE: Weight loss and small intestinal bacterial overgrowth (SIBO) are common in Parkinson's disease (PD). We aimed to study the relationship between weight loss and SIBO in PD. METHODS: This was a cross-sectional study with a prospective, interventional component. Consecutive patients seen in the PD clinic who agreed to participate underwent extensive history, movement exam, SIBO breath testing and answered questionnaires. A subset of those in the weight loss group were treated with rifaximin for 14 days and returned 3 months later for an assessment of their weight, GI symptoms, quality of life and SIBO status...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30149464/the-european-physiotherapy-guideline-for-parkinson-s-disease-implications-for-neurologists
#15
Josefa Domingos, Samyra H J Keus, John Dean, Nienke M de Vries, Joaquim J Ferreira, Bastiaan R Bloem
The evidence for physiotherapy is growing, showing a positive impact on functional activities involving gait, transfers and balance. Specific recommendations for physiotherapists, physicians and people with Parkinson's disease were published in the European Physiotherapy Guideline for Parkinson's disease. Here, we summarize the referral criteria, highlight the importance of accurate referral to specialized physiotherapists, and emphasize the potential benefits of expert care. As such, this paper offers very practical guidance for clinicians working with Parkinson's disease patients and who consider physiotherapy treatments for their patients...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30149463/parkinson-matters
#16
Sirwan K L Darweesh, Karen G Raphael, Patrik Brundin, Helen Matthews, Richard K Wyse, Honglei Chen, Bastiaan R Bloem
Recent epidemiological observations have drawn attention to the rapid rise in the burden caused by Parkinson's disease over the past years, emphasizing that Parkinson's disease is a matter of serious concern for our future generations. A recent report by Public Health England corroborates this message, by providing new insight on trends in deaths associated with neurological diseases in England between 2001 to 2014. The report indicates that mortality associated with Parkinson's disease and related disorders increased substantially between 2001 and 2014...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30149462/modeling-parkinson-s-disease-using-patient-specific-induced-pluripotent-stem-cells
#17
Hong Li, Houbo Jiang, Boyang Zhang, Jian Feng
Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterized by the degeneration of nigral dopaminergic (DA) neurons. While over 90% of cases are idiopathic, without a clear etiology, mutations in many genes have been linked to rare, familial forms of PD. It has been quite challenging to develop effective animal models of PD that capture salient features of PD. The discovery of induced pluripotent stem cells (iPSCs) makes it possible to generate patient-specific DA neurons to study PD...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30124453/precision-medicine-in-parkinson-s-disease-exploring-patient-initiated-self-tracking
#18
Sara Riggare, Maria Hägglund
BACKGROUND: Individually tailored healthcare, in the form of precision medicine, holds substantial potential for the future of medicine, especially for a complex disorder like Parkinson's disease (PD). Patient self-tracking is an under-researched area in PD. OBJECTIVE: This study aimed to explore patient-initiated self-tracking in PD and discuss it in the context of precision medicine. METHODS: The first author used a smartphone app to capture finger-tapping data and also noted times for medication intakes...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30124452/altered-cortico-limbic-network-connectivity-in-parkinsonian-depression-the-effect-of-antidepressants
#19
Howard E Morgan, Christina R Ledbetter, Christopher Ferrier, Richard M Zweig, Elizabeth A Disbrow
BACKGROUND: Depression is a common comorbidity of Parkinson's disease (PD); however, the impact of antidepressant status on cortical function in parkinsonian depression is not fully understood. While studies of resting state functional MRI in major depression have shown that antidepressant treatment affects cortical connectivity, data on connectivity and antidepressant status in PD is sparse. OBJECTIVE: We tested the hypothesis that cortico-limbic network (CLN) resting state connectivity is abnormal in antidepressant-treated parkinsonian depression...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/30124451/importance-of-balance-gait-disorder-as-a-risk-factor-for-cognitive-impairment-dementia-and-related-non-motor-symptoms-in-parkinson-s-disease
#20
David Gordon Lichter, Ralph Holmes Boring Benedict, Linda Ann Hershey
BACKGROUND: In Parkinson's disease (PD), postural instability-gait disorder (PIGD) has been associated with more rapid cognitive decline, dementia, and greater non-motor symptom (NMS) burden. OBJECTIVE: To assess the importance of balance-gait disorder, relative to and in combination with other clinical measures, as a risk factor for cognitive impairment, dementia and NMS burden in PD. METHODS: 164 PD subjects were evaluated in a retrospective cross-sectional study using the MDS-UPDRS scale, MMSE and Clinical Dementia Rating Scale...
2018: Journal of Parkinson's Disease
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