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Journal of Parkinson's Disease

Hao Deng, Kuan Fan, Joseph Jankovic
Parkinson's disease (PD) is a common neurodegenerative disease whose pathogenesis remains unknown. TMEM230 gene, encoding a transmembrane protein in secretory and recycling vesicle, has been recently identified as a novel disease-causing gene of autosomal dominant PD with Lewy pathology and typical clinical symptoms. Although its mutation and variants seem to be rare in PD patients, functional studies have indicated that TMEM230 protein probably plays an important role in secretory and recycling pathway and may be involved in Lewy pathological mechanism...
August 30, 2018: Journal of Parkinson's Disease
Beatriz Muñoz Ospina, Jaime Andrés Valderrrama Chaparro, Juan David Arango Paredes, Yor Jaggy Castaño Pino, Andrés Navarro, Jorge Luis Orozco
BACKGROUND: Arm swing changes are common even in the early stages of Parkinson's disease (PD). We hypothesized that arm swing changes decrease with age and can be detected using a low-cost, RGB-D depth-sensing camera. OBJECTIVE: This study aimed to assess the differences in arm swing between PD patients and healthy participants and to investigate the possible effects of aging on these differences. METHODS: Twenty-five PD patients (aged 45-87 years) and 25 age-matched, healthy subjects (aged 46-88 years) were included...
August 24, 2018: Journal of Parkinson's Disease
Josefa Domingos, Samyra H J Keus, John Dean, Nienke M de Vries, Joaquim J Ferreira, Bastiaan R Bloem
The evidence for physiotherapy is growing, showing a positive impact on functional activities involving gait, transfers and balance. Specific recommendations for physiotherapists, physicians and people with Parkinson's disease were published in the European Physiotherapy Guideline for Parkinson's disease. Here, we summarize the referral criteria, highlight the importance of accurate referral to specialized physiotherapists, and emphasize the potential benefits of expert care. As such, this paper offers very practical guidance for clinicians working with Parkinson's disease patients and who consider physiotherapy treatments for their patients...
August 23, 2018: Journal of Parkinson's Disease
John K DiBaise, Michael D Crowell, Erika Driver-Dunckley, Shyamal H Mehta, Charlene Hoffman-Snyder, Tanya Lin, Charles H Adler
BACKGROUND AND OBJECTIVE: Weight loss and small intestinal bacterial overgrowth (SIBO) are common in Parkinson's disease (PD). We aimed to study the relationship between weight loss and SIBO in PD. METHODS: This was a cross-sectional study with a prospective, interventional component. Consecutive patients seen in the PD clinic who agreed to participate underwent extensive history, movement exam, SIBO breath testing and answered questionnaires. A subset of those in the weight loss group were treated with rifaximin for 14 days and returned 3 months later for an assessment of their weight, GI symptoms, quality of life and SIBO status...
August 21, 2018: Journal of Parkinson's Disease
Sirwan K L Darweesh, Karen G Raphael, Patrik Brundin, Helen Matthews, Richard K Wyse, Honglei Chen, Bastiaan R Bloem
Recent epidemiological observations have drawn attention to the rapid rise in the burden caused by Parkinson's disease over the past years, emphasizing that Parkinson's disease is a matter of serious concern for our future generations. A recent report by Public Health England corroborates this message, by providing new insight on trends in deaths associated with neurological diseases in England between 2001 to 2014. The report indicates that mortality associated with Parkinson's disease and related disorders increased substantially between 2001 and 2014...
August 20, 2018: Journal of Parkinson's Disease
Hong Li, Houbo Jiang, Boyang Zhang, Jian Feng
Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterized by the degeneration of nigral dopaminergic (DA) neurons. While over 90% of cases are idiopathic, without a clear etiology, mutations in many genes have been linked to rare, familial forms of PD. It has been quite challenging to develop effective animal models of PD that capture salient features of PD. The discovery of induced pluripotent stem cells (iPSCs) makes it possible to generate patient-specific DA neurons to study PD...
August 20, 2018: Journal of Parkinson's Disease
David Gordon Lichter, Ralph Holmes Boring Benedict, Linda Ann Hershey
BACKGROUND: In Parkinson's disease (PD), postural instability-gait disorder (PIGD) has been associated with more rapid cognitive decline, dementia, and greater non-motor symptom (NMS) burden. OBJECTIVE: To assess the importance of balance-gait disorder, relative to and in combination with other clinical measures, as a risk factor for cognitive impairment, dementia and NMS burden in PD. METHODS: 164 PD subjects were evaluated in a retrospective cross-sectional study using the MDS-UPDRS scale, MMSE and Clinical Dementia Rating Scale...
August 13, 2018: Journal of Parkinson's Disease
Seyed-Mohammad Fereshtehnejad, Johan Lökk, Anders Wimo, Maria Eriksdotter
BACKGROUND: Whether dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are distinct disorders or two subtypes of the same entity, is not yet fully understood. There is a dearth of knowledge on differences in longitudinal clinical outcomes between DLB and PDD. OBJECTIVE: We aimed to compare longitudinal trend of cognitive decline, mortality, and their determinant factors between patients with DLB and PDD. METHODS: At baseline, we recruited 1110 DLB, and 764 PDD patients registered in the Swedish dementia registry (SveDem) during 2007- 2015...
August 7, 2018: Journal of Parkinson's Disease
(no author information available yet)
No abstract text is available yet for this article.
March 26, 2018: Journal of Parkinson's Disease
Sara Riggare, Maria Hägglund
BACKGROUND: Individually tailored healthcare, in the form of precision medicine, holds substantial potential for the future of medicine, especially for a complex disorder like Parkinson's disease (PD). Patient self-tracking is an under-researched area in PD. OBJECTIVE: This study aimed to explore patient-initiated self-tracking in PD and discuss it in the context of precision medicine. METHODS: The first author used a smartphone app to capture finger-tapping data and also noted times for medication intakes...
2018: Journal of Parkinson's Disease
Howard E Morgan, Christina R Ledbetter, Christopher Ferrier, Richard M Zweig, Elizabeth A Disbrow
BACKGROUND: Depression is a common comorbidity of Parkinson's disease (PD); however, the impact of antidepressant status on cortical function in parkinsonian depression is not fully understood. While studies of resting state functional MRI in major depression have shown that antidepressant treatment affects cortical connectivity, data on connectivity and antidepressant status in PD is sparse. OBJECTIVE: We tested the hypothesis that cortico-limbic network (CLN) resting state connectivity is abnormal in antidepressant-treated parkinsonian depression...
2018: Journal of Parkinson's Disease
Kristina Rosqvist, Per Odin, Peter Hagell, Susanne Iwarsson, Maria H Nilsson, Alexander Storch
BACKGROUND: Non-motor symptoms (NMS) are common in late stage Parkinson's disease (PD), as the frequency and severity of most of these symptoms increase with advancing disease. OBJECTIVE: To assess effect of dopaminergic therapy on NMS in late stage PD and to investigate relationships between dopaminergic effect on NMS and on motor function. METHOD: Thirty PD patients in Hoehn and Yahr (HY) stages IV and V in "on" were included. Dopaminergic effect on non-motor symptomatology was assessed by the modified version of the Non-Motor Symptoms Scale (NMSS) in the "off" and the "on" state during a standardized L-dopa test, in parallel also assessing motor function...
2018: Journal of Parkinson's Disease
Ahmed Al-Qassabi, Amélie Pelletier, Seyed-Mohammad Fereshtehnejad, Ronald B Postuma
BACKGROUND: Autonomic dysfunctions including sudomotor abnormalities commonly occur in early Parkinson's disease (PD), but little is known about potential sudomotor abnormalities in idiopathic REM Sleep Behavior Disorder (iRBD), a strong prodromal marker of PD. OBJECTIVE: Our aim was to assess sudomotor dysfunction by galvanic skin response using SudoScan, as well as other autonomic markers in 49 iRBD, 40 PD (21 with RBD, 19 without), 20 atypical parkinsonisms, and 41 age-matched controls...
2018: Journal of Parkinson's Disease
Meltem Ciliz, Jennifer Sartor, Tobias Lindig, Andrea Pilotto, Eva Schäffer, Michael Weiss, Philip Scheltens, Sara Becker, Markus A Hobert, Daniela Berg, Inga Liepelt-Scarfone, Walter Maetzler
BACKGROUND: Falls are common among people with idiopathic Parkinson's disease (IPD) and are suggested to be associated with white matter hyperintensities (WMH) of the brain. OBJECTIVE: To investigate the contribution of brain area-specific WMH to the risk of falls in IPD. METHODS: In fifty participants with IPD, occurrence and severity of WMH in specific brain areas were determined using Scheltens (without lateralization) and Age-related white matter changes (ARWMC) (with lateralization) scores...
2018: Journal of Parkinson's Disease
Benjamin J Clegg, Gordon W Duncan, Tien K Khoo, Roger A Barker, David J Burn, Alison J Yarnall, Rachael A Lawson
BACKGROUND: Visual hallucinations (VHs) are common in Parkinson's disease (PD), with prevalence ranging from 27-50% in cross-sectional cohorts of patients with well-established disease. However, minor hallucinations may occur earlier in the disease process than has been previously reported. OBJECTIVE: We sought to categorise VHs in a cohort of newly diagnosed PD patients and establish their relationship to other clinical features. METHODS: Newly diagnosed PD participants (n = 154) were recruited as part of the Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in PD (ICICLE-PD) study...
2018: Journal of Parkinson's Disease
K Grace Cannard, Mallory L Hacker, Anna Molinari, Lauren E Heusinkveld, Amanda D Currie, David Charles
BACKGROUND: Clinical trials are often hindered by inadequate patient recruitment. Overly optimistic investigator predictions of participation can lead to unmet recruitment goals and costly trial extensions. A patient-focused approach estimating recruitment in clinical trials may provide higher accuracy. OBJECTIVE: To assess the feasibility of recruitment in a future deep brain stimulation (DBS) in early-stage Parkinson's disease (PD) multicenter trial by understanding motivations and concerns to participation of past and potential future DBS in early-stage PD clinical trial subjects...
2018: Journal of Parkinson's Disease
Makoto Hashimoto, Gilbert Ho, Yoshiki Takamatsu, Yuka Shimizu, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Eliezer Masliah
At present, the precise physiological role of neurodegenerative disease-related amyloidogenic proteins (APs), including α-synuclein in Parkinson's disease and β-amyloid in Alzheimer's disease, remains unclear. Because of similar adaptability of both human brain neurons and yeast cells to diverse environmental stressors, we previously proposed that the concept of evolvability in yeast prion could also be applied to APs in human brain. However, the mechanistic relevance of evolvability to neurodegenerative disorders is elusive...
2018: Journal of Parkinson's Disease
Anindita Bose, Gregory A Petsko, David Eliezer
Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, depletion of dopamine in the striatum and the presence of Lewy bodies. Cancer is uncontrolled growth of cells in the body and migration of these cells from their site of origin to other parts of the body. PD and cancer are two opposite diseases, one arising from cell proliferation and the other from cell degeneration. This fundamental difference is consistent with inverse comorbidity between most cancers and neurodegenerative diseases...
2018: Journal of Parkinson's Disease
Rivka Inzelberg, Alejandro Estrada-Cuzcano, Yael Laitman, Els De Vriendt, Eitan Friedman, Albena Jordanova
Kufor-Rakeb syndrome (KRS)/PARK9 presents with autosomal recessive young onset Parkinson's disease (YOPD), spastic paraparesis, abnormal eye movements and facial myokymia. KRS is caused by homozygous/compound heterozygous inactivating mutations in ATP13A2. Two affected siblings (born to non-consanguineous Jewish parents) presenting a similar KRS phenotype (onset age 27, 23), carried compound heterozygous pathogenic variants in ATP13A2: c.217_218insG and c.3057delC. Allele frequency of the c.3057delC mutation was about 100 times higher in Ashkenazi controls in our study (1/190 = 0...
2018: Journal of Parkinson's Disease
David J McGee, Xiao-Hong Lu, Elizabeth A Disbrow
While a small subset of Parkinson's disease cases have genetic causes, most cases are sporadic and may have an environmental contributor that has largely remained enigmatic. Remarkably, gastrointestinal symptoms in PD patients serve as a prodrome for the eventual motor dysfunctions. Herein, we review studies exploring a possible link between the gastric human pathogen Helicobacter pylori and PD. We provide plausible and testable hypotheses for how this organism might contribute to PD: 1) a toxin(s) produced by the bacteria; 2) disruption of the intestinal microbiome; 3) local inflammation that crosses the gut-brain axis, leading to neuroinflammation; and 4) manipulation of the pharmacokinetics of the PD drug levodopa by H...
2018: Journal of Parkinson's Disease
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