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Journal of Parkinson's Disease

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https://www.readbyqxmd.com/read/29154293/the-changing-landscape-of-parkinson-epidemiologic-research
#1
Honglei Chen
Despite recent successes in understanding the genetics of Parkinson's disease (PD), the causes of late-onset sporadic PD remain elusive. Many of the epidemiologic findings on PD etiology have been challenged by alternative explanations such as reverse causation. This is mainly because PD often takes decades to develop before it can be diagnosed late in life. Convincing evidence shows that this prodromal stage of PD is characterized by various prodromal symptoms such as olfactory impairment and rapid-eye-movement sleep behavior disorder (RBD)...
November 14, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29154292/increased-prevalence-of-polyneuropathy-in%C3%A2-parkinson-s-disease-patients-an%C3%A2-observational-study
#2
Christian Conradt, Dianlin Guo, Anca Miclea, Thomas Nisslein, Chaim Ismail, Krai Chatamra, Frank Andersohn
This study investigated whether patients with newly diagnosed Parkinson's disease (PD) without previous exposure to antiparkinsonian drugs have higher prevalence of polyneuropathy than the general population. Using the UK General Practice Research Database, presence of polyneuropathy in the previous 3 years was assessed. Of 5089 PD patients and 19,897 controls, polyneuropathy was confirmed in 15 PD patients (0.29%) and 24 controls (0.12%). Polyneuropathy prevalence was 2.4-fold higher in PD patients than controls...
November 14, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28409750/clinical-characteristics-of-parkinson-s-disease-developed-from-essential-tremor
#3
Dong-Woo Ryu, Si-Hoon Lee, Yoon-Sang Oh, Jae-Young An, Jeong-Wook Park, In-Uk Song, Kwang-Soo Lee, Joong-Seok Kim
BACKGROUND: Recent genetic and epidemiological studies have shown that there is a link between essential tremor and Parkinson's disease (PD). However, there is a lack of data about the clinical features of PD developed from essential tremor. OBJECTIVE: To explore and describe the clinical characteristics of Parkinson's disease developed from essential tremor (ET-PD). METHODS: Twenty-five ET-PD patients and 124 IPD controls were enrolled according to each criterion...
April 13, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28409749/the-role-of-stress-as-a-risk-factor-for-progressive-supranuclear-palsy
#4
Kristen D Kelley, Guerry Peavy, Steven Edland, Whitney Rogers, David E Riley, Yvette Bordelon, David Standaert, Stephen G Reich, Irene Litvan
BACKGROUND: PSP, like Alzheimer's disease (AD), is a tauopathy. The etiopathogenesis of PSP is not well known and the role of stress has not yet been examined. Recent studies have shown that stress increases the risk for developing AD. This study investigates the role of stress as a risk factor for PSP. OBJECTIVE: B To examine the association between the development of progressive supranuclear palsy (PSP) and self-reported life stressors. METHODS: 76 patients diagnosed with PSP according to the NINDS-SPSP criteria and 68 age-matched unrelated controls were administered a life stressor questionnaire...
April 13, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28387683/appendectomy-history-is-not-related-to-parkinson-s-disease
#5
Rezzak Yilmaz, Ece Bayram, Çağrı Ulukan, Mustafa Kemal Altınok, Muhittin Cenk Akbostancı
BACKGROUND: It has been suggested that appendectomy may modify the emergence of Parkinson's disease (PD) by affecting the retrograde transport of α-synuclein (α-syn) from the gastrointestinal system. OBJECTIVE: To explore the possible role of appendectomy on PD. METHODS: The retrospective data of the 1625 patients (839 PD, 633 non-α-syn parkinsonism and 153 controls) were compared. Disease specific measures between PD patients with (n = 69) and without (n = 770) appendectomy were also evaluated...
April 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28387681/prevalence-of-prodromal-parkinson-s-disease-as-defined-by-mds-research-criteria-among-elderly-patients-undergoing-colonoscopy
#6
Skorvanek Matej, Ladomirjakova Zuzana, Han Vladimir, Lesko Norbert, Feketeova Eva, Jarcuskova Dominika, Repkova Barbora, Spisak Peter, Urbancikova Zuzana, Vargova Adriana, Gombosova Laura, Zakuciova Maria, Veseliny Eduard, Trebuna Frantisek, Mechirova Eva, Gdovinova Zuzana
BACKGROUND: Gastrointestinal symptoms are a well-recognized and common premotor feature of Parkinson's disease (PD). Moreover, multiple studies have assessed the value of colonic α-synuclein as a potential marker of prodromal PD. Recently, the International Parkinson and Movement Disorders Society (MDS) defined research criteria for prodromal PD. OBJECTIVE: The aim of our study was to test the MDS research criteria in patients undergoing diagnostic colonoscopies as potential candidates for inclusion in prospective trials evaluating colonic biopsies as a potential biomarker of prodromal PD...
April 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28339403/dopamine-transporter-imaging-has-no-impact-on-functional-outcomes-in-de-novo-probable-parkinson-s-disease
#7
Patrick T Hickey, Maragatha Kuchibhatla, Burton Scott, Lisa Gauger, Mark A Stacy
BACKGROUND: Parkinson's disease (PD) is among the most prevalent neurodegenerative conditions. While motor and non-motor aspects of this disease have been well characterized, no objective biomarker exists to support an accurate clinical diagnosis. However, newer imaging techniques, including [123I]-FP-CIT (DaTSCAN), have demonstrated utility in differentiating between PD and non-neurodegenerative tremor disorders. OBJECTIVE: DaTSCAN has been primarily investigated in situations where diagnostic confusion exists, and in these instances has been shown to significantly impact clinical management...
March 20, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28234259/the-potential-role-of-gut-derived-inflammation-in-multiple-system-atrophy
#8
Phillip A Engen, Hemraj B Dodiya, Ankur Naqib, Christopher B Forsyth, Stefan J Green, Robin M Voigt, Jeffrey H Kordower, Ece A Mutlu, Kathleen M Shannon, Ali Keshavarzian
BACKGROUND: Recent evidence suggests that Parkinson's disease (PD) is associated with intestinal microbiota dysbiosis, abnormal intestinal permeability, and intestinal inflammation. OBJECTIVE: Our study aimed to determine if these gut abnormalities are present in another synucleinopathy, multiple system atrophy (MSA). METHODS: In six MSA and 11 healthy control subjects, we performed immunohistochemistry studies of colonic sigmoid mucosa to evaluate the intestinal barrier marker Zonula Occludens-1 and the endotoxin-related inflammation marker Toll-like-receptor-4 expression...
February 20, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#9
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222536/predictors-of-recurrent-falls-in-people-with%C3%A2-parkinson-s-disease-and-proposal-for%C3%A2-a%C3%A2-predictive-tool
#10
Lorena R S Almeida, Guilherme T Valenca, Nádja N Negreiros, Elen B Pinto, Jamary Oliveira-Filho
BACKGROUND: Falls are a debilitating problem for people with Parkinson's disease (PD). OBJECTIVES: To compare clinical and functional characteristics of non-fallers, single and recurrent fallers (≥2 falls); to determine predictors of time to second fall; and to develop a predictive tool for identifying people with PD at different categories of falls risk. METHODS: Participants (n = 229) were assessed by disease-specific, self-report and balance measures and followed up for 12 months...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28157109/objective-colonic-dysfunction-is-far-more-prevalent-than-subjective-constipation-in-parkinson-s-disease-a-colon-transit-and-volume-study
#11
Karoline Knudsen, Tatyana D Fedorova, Anne C Bekker, Peter Iversen, Karen Østergaard, Klaus Krogh, Per Borghammer
BACKGROUND: Gastrointestinal function has received increased interest in the context of Parkinson's disease (PD). Constipation is among the most frequent non-motor symptoms, but our understanding of the underlying pathology is limited. Subjective constipation correlates poorly with objective markers. OBJECTIVE: The aims were to evaluate colonic transit time and volume in PD and to correlate these measures with subjective symptoms and gastric emptying. METHODS: Thirty-two PD patients and 26 controls were included...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28157107/the-cross-sectional-area-of-paraspinal-muscles-predicts-the-efficacy-of-deep-drain-stimulation-for-camptocormia
#12
Waka Sakai, Shunya Nakane, Eiichirou Urasaki, Keisuke Toyoda, Eisaku Sadakata, Akiko Nagaishi, Takayasu Fukudome, Yuzo Yamakawa, Hidenori Matsuo
BACKGROUND: Camptocormia, a disturbance of posture, is a well-described clinical feature of PD and other parkinsonian syndromes. Previous reports have shown that DBS of the subthalamic nucleus (STN) or globus pallidus internus is effective in treating camptocormia. However, the efficacy of DBS for camptocormia varies. OBJECTIVE: To determine a clinical marker for selecting an appropriate therapy for camptocormia, a disabling manifestation of Parkinson's disease (PD) that has a variable response to systemic and local therapies...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28157106/disability-in-activities-of-daily-living-and%C3%A2-severity-of-dyskinesias-determine-the%C3%A2-handicap-of-parkinson-s-disease-patients-in%C3%A2-advanced-stage-selected-to-dbs
#13
Miguel Coelho, Daisy Abreu, Leonor Correia-Guedes, Patricia Pita Lobo, Margherita Fabbri, Catarina Godinho, Josefa Domingos, Luisa Albuquerque, Vanda Freitas, João Miguel Pereira, Begona Cattoni, Herculano Carvalho, Sofia Reimão, Mário M Rosa, António Gonalves Ferreira, Joaquim J Ferreira
BACKGROUND: There is scarce data on the level of handicap in Parkinson's disease (PD) and none in advanced stage PD. OBJECTIVE: To assess the handicap in advanced stage PD patients with disabling levodopa-induced motor complications selected to deep brain stimulation (DBS). METHODS: Data was prospectively recorded during routine evaluation for DBS. Handicap was measured using London Handicap Scale (LHS) (0 = maximal handicap; 1 = no handicap)...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29103054/is-the-enzyme-acmsd-a-novel-therapeutic-target-in-parkinson-s-disease
#14
Keerthi Thirtamara-Rajamani, Peipei Li, Martha L Escobar Galvis, Viviane Labrie, Patrik Brundin, Lena Brundin
 Several large genome wide association studies have identified a locus in close proximity to the gene encoding the enzyme aminocarboxymuconate-semialdehyde-decarboxylase (ACMSD) to be associated with the risk for Parkinson's disease (PD), tentatively suggesting that this enzyme might influence PD pathogenesis. Further support for this comes from the recent identification of a disease-segregating stop codon mutation in ACMSD in a family with Parkinsonism, and a missense mutation in the ACMSD gene predicted to disrupt enzyme function in an individual with typical PD...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29103053/domperidone-for-hypotension-in-parkinson-s-disease-a-systematic-review
#15
Stephen Bacchi, Ivana Chim, Philippe Kramer, Ronald B Postuma
BACKGROUND: Domperidone is a proposed treatment of orthostatic hypotension (OH) in Parkinson's disease (PD). However, domperidone use in PD is tempered by concerns regarding QT prolongation and ventricular tachyarrhythmia and sudden cardiac death (VT/SCD). OBJECTIVE: The aim is to identify peer-reviewed studies in which either (1) the effect of domperidone on blood pressure in patients with PD, or (2) the adverse effects associated with domperidone use in PD patients has been reported...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29103052/increasing-efficiency-of-recruitment-in-early-parkinson-s-disease-trials-a-case-study-examination-of-the-steady-pd-iii-trial
#16
Sarah Berk, Brittany L Greco, Kevin Biglan, Catherine M Kopil, Robert G Holloway, Claire Meunier, Tanya Simuni
BACKGROUND: Challenges in clinical trial recruitment threaten the successful development of improved therapies. This is particularly true in Parkinson's disease (PD) studies of disease modification where the population of interest is difficult to find and study design is more complex. OBJECTIVE: This paper seeks to understand how STEADY PD III, a National Institute of Neurological Disorders and Stroke (NINDS) funded phase 3 trial evaluating the efficacy of isradipine as a disease modifying agent for PD, was able to recruit their full target population 6 months ahead of schedule...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29103051/c-abl-and-parkinson-s-disease-mechanisms-and-therapeutic-potential
#17
Saurav Brahmachari, Senthilkumar S Karuppagounder, Preston Ge, Saebom Lee, Valina L Dawson, Ted M Dawson, Han Seok Ko
 Although the etiology of Parkinson's disease (PD) is poorly understood, oxidative stress has long been implicated in the pathogenesis of the disease. However, multifaceted and divergent signaling cascades downstream of oxidative stress have posed challenges for researchers to identify a central component of the oxidative stress-induced pathways causing neurodegeneration in PD. Since 2010, c-Abl-a non-receptor tyrosine kinase and an indicator of oxidative stress-has shown remarkable potential as a future promising drug target in PD therapeutics...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29103050/motivators-and-barriers-to-exercise-in-parkinson-s-disease
#18
Mitra Afshari, Amy Yang, Danny Bega
BACKGROUND: Despite evidence for the benefits of exercise in Parkinson's disease (PD), many patients remain sedentary for undefined reasons. OBJECTIVE: To compare exercise habits, perceptions about exercise, and barriers to exercise in 'low' (<3 h/week) and 'high' (≥3 h/week) exercisers with PD. METHODS: A 48-item survey was administered to PD patients at an outpatient academic center. Chi-squared tests were used to compare the percentage differences between low- and high-exercisers with two-sided tests and a significant level of 0...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29103049/challenges-to-informed-consent-in-first-in-human-trials-involving-novel-treatments-a-case-study-of-parkinson-s-disease
#19
Kristina Hug, Mats Johansson
Obtaining informed consent in clinical trials can be challenging both for researchers and for patients, albeit in different ways. The challenge concerns not only how to provide the needed information, but also what information to focus on when dealing with individual patients who have different goals, needs, histories, etc. This paper aims to contribute to a better informed consent process for Parkinson's patients taking part in first-in-human clinical trials of cell replacement therapies. It outlines a range of problems which patients and researchers may face in this process and provides practical advice to researchers engaged in such trials...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29103048/treadmill-training-with-cues-and-feedback-improves-gait-in-people-with-more-advanced-parkinson-s-disease
#20
Valeria Studer, Roberto Maestri, Ilaria Clerici, Letizia Spina, Ilaria Zivi, Davide Ferrazzoli, Giuseppe Frazzitta
BACKGROUND: Gait disturbances in Parkinson's disease (PD) are highly disabling and poorly responsive to drugs, especially in advanced stages. While the efficacy of a treadmill training based on external feedback and cues (treadmill-plus) on gait disturbances in early PD stages is demonstrated, no definitive evidence exists about advanced stages. OBJECTIVE: We aimed to evaluate the feasibility and the effects of a treadmill-plus training on gait disturbances in advanced PD...
2017: Journal of Parkinson's Disease
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